Detailed information for compound 1257743

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 520.6 | Formula: C27H28N4O5S
  • H donors: 4 H acceptors: 6 LogP: 2.25 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 2
  • SMILES: OC(COc1ccc(c(c1)C(=O)O)O)CNC1CCN(CC1)c1ncnc2c1c(cs2)c1ccccc1
  • InChi: 1S/C27H28N4O5S/c32-19(14-36-20-6-7-23(33)21(12-20)27(34)35)13-28-18-8-10-31(11-9-18)25-24-22(17-4-2-1-3-5-17)15-37-26(24)30-16-29-25/h1-7,12,15-16,18-19,28,32-33H,8-11,13-14H2,(H,34,35)
  • InChiKey: NPOJTLRAMYFXPE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens adrenoceptor beta 1 Starlite/ChEMBL References
Homo sapiens adrenoceptor beta 3 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0164 0.2883 0.5528
Schistosoma mansoni cathepsin F (C01 family) 0.0031 0.0393 0.0392
Mycobacterium tuberculosis Probable hydrolase 0.0034 0.0441 0.0981
Plasmodium vivax proline--tRNA ligase, putative 0.0036 0.0473 0.0599
Loa Loa (eye worm) hypothetical protein 0.0033 0.0426 0.0532
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0031 0.0393 0.2124
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0016 0.0109 0.0108
Brugia malayi Cathepsin L-like precursor 0.0031 0.0393 0.0858
Plasmodium falciparum protein kinase 7 0.0288 0.5184 0.6559
Trypanosoma cruzi trypanothione reductase, putative 0.0014 0.007 0.0336
Echinococcus multilocularis lysyl tRNA synthetase 0.0023 0.0232 0.0195
Trypanosoma cruzi hexose transporter 0.0032 0.0398 0.1947
Loa Loa (eye worm) hypothetical protein 0.0034 0.0441 0.055
Toxoplasma gondii transporter, major facilitator family protein 0.0014 0.0075 0.0072
Mycobacterium ulcerans lipase LipD 0.0034 0.0441 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.039 0.0354
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0016 0.0109 0.0202
Brugia malayi Intermediate filament tail domain containing protein 0.0021 0.0206 0.0449
Mycobacterium tuberculosis Conserved protein 0.0034 0.0441 0.0981
Leishmania major cathepsin L-like protease 0.0119 0.2038 1
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0473 0.205
Schistosoma mansoni hypothetical protein 0.0043 0.0607 0.0606
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.039 0.0354
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0075 0.0223
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0164 0.2883 0.3655
Loa Loa (eye worm) hypothetical protein 0.0023 0.0232 0.0289
Schistosoma mansoni zinc finger protein 0.0043 0.0607 0.0606
Trypanosoma brucei glucose transporter, putative 0.0032 0.0398 0.1667
Trichomonas vaginalis chromobox protein, putative 0.0075 0.1215 0.7037
Loa Loa (eye worm) hypothetical protein 0.0021 0.0206 0.0256
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0012 0.0038 0.0083
Brugia malayi hypothetical protein 0.0014 0.0075 0.0164
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0014 0.007 0.1397
Entamoeba histolytica cysteine protease, putative 0.0016 0.0109 0.1253
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0075 0.0164
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0109 0.0238
Loa Loa (eye worm) hypothetical protein 0.0021 0.02 0.0248
Loa Loa (eye worm) latrophilin receptor protein 2 0.0042 0.0594 0.0742
Schistosoma mansoni protein kinase 0.0031 0.039 0.0389
Plasmodium vivax vivapain-2 0.0031 0.0393 0.0497
Onchocerca volvulus 0.0014 0.0075 0.0082
Toxoplasma gondii lysine-tRNA ligase 0.0023 0.0232 0.0378
Onchocerca volvulus 0.0031 0.0393 0.0781
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0119 0.2038 1
Echinococcus multilocularis microtubule associated protein 2 0.0545 1 1
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0075 0.0223
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0103 0.1724 0.4374
Leishmania major glycerol uptake protein, putative 0.0043 0.0607 0.273
Entamoeba histolytica cysteine protease, putative 0.0016 0.0109 0.1253
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0075 0.0223
Loa Loa (eye worm) hypothetical protein 0.0031 0.039 0.0487
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0031 0.0393 0.2124
Brugia malayi Cathepsin L-like precursor 0.0021 0.02 0.0435
Loa Loa (eye worm) hhat protein 0.0043 0.0607 0.0758
Brugia malayi MH1 domain containing protein 0.0015 0.0092 0.0201
Brugia malayi MBOAT family protein 0.0043 0.0607 0.1324
Echinococcus granulosus Membrane bound O acyl transferase MBOAT 0.0043 0.0607 0.0571
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0014 0.0075 0.1528
Schistosoma mansoni sugar transporter 0.0014 0.0075 0.0074
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0034 0.0441 0.0981
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0075 0.0223
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0093 0.1549 0.1937
Loa Loa (eye worm) hypothetical protein 0.0012 0.0038 0.0046
Entamoeba histolytica cysteine protease, putative 0.0016 0.0109 0.1253
Onchocerca volvulus 0.0034 0.0441 0.0886
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0043 0.0607 0.0606
Echinococcus multilocularis solute carrier family 22 0.0014 0.0075 0.0037
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0075 0.0223
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0043 0.0607 0.0606
Schistosoma mansoni cathepsin F (C01 family) 0.0021 0.02 0.0198
Loa Loa (eye worm) hypothetical protein 0.0043 0.0607 0.0758
Schistosoma mansoni chromobox protein 0.0012 0.0038 0.0037
Loa Loa (eye worm) hypothetical protein 0.0012 0.0038 0.0046
Echinococcus multilocularis Membrane bound O acyl transferase, MBOAT 0.0043 0.0607 0.0571
Plasmodium vivax hypothetical protein, conserved 0.0012 0.0038 0.0047
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0031 0.0391 0.0685
Brugia malayi intermediate filament protein 0.0021 0.0206 0.0449
Echinococcus granulosus diacylglycerol O acyltransferase 1 0.0043 0.0607 0.0571
Entamoeba histolytica cysteine proteinase 2 0.0016 0.0109 0.1253
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0232 0.1162
Schistosoma mansoni protein kinase 0.0031 0.039 0.0389
Trichomonas vaginalis porcupine, putative 0.0043 0.0607 0.3403
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0031 0.0393 0.2124
Toxoplasma gondii facilitative glucose transporter GT1 0.0102 0.1711 0.325
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0031 0.039 0.0487
Trichomonas vaginalis esterase, putative 0.0034 0.0441 0.2408
Brugia malayi Protein cec-1. 0.0012 0.0038 0.0083
Onchocerca volvulus 0.0031 0.0393 0.0781
Loa Loa (eye worm) hypothetical protein 0.0014 0.0075 0.0093
Plasmodium falciparum glutathione reductase 0.004 0.0563 0.067
Loa Loa (eye worm) MBOAT family protein 0.0043 0.0607 0.0758
Trichomonas vaginalis chromobox protein, putative 0.0045 0.0656 0.3697
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0014 0.0075 0.0037
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0014 0.007 0.0336
Entamoeba histolytica cysteine protease, putative 0.0016 0.0109 0.1253
Plasmodium vivax heterochromatin protein 1, putative 0.0012 0.0038 0.0047
Echinococcus granulosus o acyltransferase membrane bound domain 0.0043 0.0607 0.0571
Mycobacterium tuberculosis Probable lipase LipD 0.0034 0.0441 0.0981
Echinococcus granulosus mothers against decapentaplegic 5 0.0015 0.0092 0.0054
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0043 0.0607 1
Plasmodium falciparum thioredoxin reductase 0.0014 0.007 0.004
Trichomonas vaginalis glucose transporter, putative 0.0014 0.0075 0.0223
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0607 0.3403
Loa Loa (eye worm) hypothetical protein 0.0014 0.0075 0.0093
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.001 0.0001 0.0003
Brugia malayi Cathepsin L-like precursor 0.0031 0.0393 0.0858
Brugia malayi MBOAT family protein 0.0043 0.0607 0.1324
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0075 0.0223
Schistosoma mansoni glucose transport protein 0.0102 0.1711 0.171
Plasmodium vivax vivapain-2 0.0031 0.0393 0.0497
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0031 0.0393 0.2124
Loa Loa (eye worm) hypothetical protein 0.0012 0.0038 0.0046
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0119 0.2038 1
Schistosoma mansoni cathepsin F (C01 family) 0.0031 0.0393 0.0392
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0103 0.1724 0.4374
Echinococcus granulosus solute carrier family 22 0.0014 0.0075 0.0037
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0031 0.0393 0.2124
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0043 0.0607 0.0571
Brugia malayi hypothetical protein 0.0012 0.0038 0.0083
Loa Loa (eye worm) hypothetical protein 0.0014 0.0075 0.0093
Trypanosoma brucei glucose transporter, putative 0.0032 0.0398 0.1667
Leishmania major glucose transporter, lmgt1 0.0032 0.0398 0.1667
Echinococcus multilocularis membrane bound acyltransferase:hhat 0.0043 0.0607 0.0571
Toxoplasma gondii thioredoxin reductase 0.004 0.0563 0.1021
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0031 0.0393 0.2124
Brugia malayi Cathepsin L-like precursor 0.0031 0.0393 0.0858
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0031 0.0393 0.049
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0109 0.0238
Leishmania major glycerol uptake protein, putative 0.0043 0.0607 0.273
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0031 0.0393 0.0453
Loa Loa (eye worm) hypothetical protein 0.0014 0.0075 0.0093
Brugia malayi lysyl-tRNA synthetase 0.0023 0.0232 0.0507
Brugia malayi Pax transcription factor protein 2 0.0255 0.4584 1
Loa Loa (eye worm) hypothetical protein 0.0395 0.7193 0.9
Trichomonas vaginalis sugar transport protein, putative 0.0014 0.0075 0.0223
Trichomonas vaginalis chromobox protein, putative 0.0045 0.0656 0.3697
Giardia lamblia Prolyl-tRNA synthetase 0.0031 0.0378 1
Echinococcus granulosus cysteine protease 0.0016 0.0109 0.0072
Plasmodium vivax sugar transporter, putative 0.0014 0.0075 0.0094
Plasmodium vivax unspecified product 0.0016 0.0109 0.0137
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0232 0.0231
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0031 0.0378 0.0342
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0398 0.1947
Trypanosoma cruzi cysteine peptidase, putative 0.0016 0.0109 0.053
Plasmodium falciparum calcium-dependent protein kinase 3 0.0031 0.0391 0.045
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0133 0.2295 0.5005
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0014 0.0075 0.1528
Echinococcus multilocularis cysteine protease 0.0031 0.0393 0.0357
Echinococcus granulosus lamin dm0 0.0021 0.0206 0.0169
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0092 0.1532 0.3865
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0607 0.3403
Onchocerca volvulus 0.0021 0.0206 0.0369
Echinococcus multilocularis calcium dependent protein kinase 0.0029 0.0354 0.0318
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0075 0.0223
Trypanosoma cruzi glycerol uptake protein, putative 0.0043 0.0607 0.2974
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0031 0.0393 0.2124
Mycobacterium ulcerans esterase/lipase LipP 0.0034 0.0441 1
Loa Loa (eye worm) MH1 domain-containing protein 0.0015 0.0092 0.0114
Loa Loa (eye worm) beta-lactamase 0.0034 0.0441 0.055
Entamoeba histolytica cysteine protease, putative 0.0016 0.0109 0.1253
Leishmania major glucose transporter, lmgt3 0.0032 0.0398 0.1667
Echinococcus granulosus lysyl tRNA synthetase 0.0023 0.0232 0.0195
Plasmodium falciparum cysteine proteinase falcipain 3 0.0031 0.0393 0.0453
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0031 0.0393 0.2124
Plasmodium falciparum protein kinase 6 0.0432 0.7884 1
Leishmania major hypothetical protein, conserved 0.0014 0.0075 0.0029
Schistosoma mansoni hypothetical protein 0.0012 0.0038 0.0037
Trypanosoma brucei glucose transporter, putative 0.0032 0.0398 0.1667
Schistosoma mansoni chromobox protein 0.0075 0.1215 0.1214
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0092 0.1532 0.3865
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0031 0.0393 0.2124
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0031 0.0391 0.0494
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0034 0.0441 1
Plasmodium falciparum hexose transporter 0.0102 0.1711 0.2132
Treponema pallidum NADH oxidase 0.0014 0.007 0.1008
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0398 0.2151
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.007 0.0336
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0012 0.0038 0.0037
Echinococcus multilocularis lamin 0.0021 0.0206 0.0169
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0014 0.007 0.0032
Trypanosoma cruzi GUP1, putative 0.0043 0.0607 0.2974
Echinococcus granulosus cathepsin l1 0.0031 0.0393 0.0357
Echinococcus multilocularis solute carrier family 22 0.0014 0.0075 0.0037
Echinococcus multilocularis solute carrier family 22 0.0014 0.0075 0.0037
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.002 0.018 0.0849
Loa Loa (eye worm) MH2 domain-containing protein 0.0223 0.3982 0.4982
Loa Loa (eye worm) heterochromatin protein 1 0.0075 0.1215 0.1519
Echinococcus multilocularis chromobox protein 1 0.0075 0.1215 0.1181
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0075 0.0223
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0031 0.039 0.0487
Echinococcus granulosus TGF beta signal transducer SmadC 0.0015 0.0092 0.0054
Loa Loa (eye worm) hypothetical protein 0.0133 0.2295 0.287
Onchocerca volvulus 0.0014 0.0075 0.0082
Toxoplasma gondii acyl-CoA:diacylglycerol acyltransferase 1-related enzyme 0.0043 0.0607 0.1106
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0232 0.5171
Brugia malayi cathepsin F-like cysteine proteinase 0.001 0.0001 0.0003
Entamoeba histolytica cysteine protease, putative 0.0016 0.0109 0.1253
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0398 0.1667
Toxoplasma gondii NADPH-glutathione reductase 0.0014 0.007 0.0061
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0031 0.0378 0.0342
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0075 0.0223
Brugia malayi Thioredoxin reductase 0.004 0.0563 0.1229
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0016 0.0109 0.0108
Schistosoma mansoni smad1 5 8 and 0.0015 0.0092 0.0091
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0014 0.0075 0.0074
Trypanosoma cruzi cysteine protease, putative 0.0016 0.0109 0.053
Brugia malayi Smad1 0.0015 0.0092 0.0201
Brugia malayi hypothetical protein 0.0014 0.0075 0.0164
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0014 0.007 0.0336
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0109 0.0426
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.1549 0.1548
Trypanosoma brucei glycerol uptake protein, putative 0.0043 0.0607 0.273
Trichomonas vaginalis conserved hypothetical protein 0.0102 0.1711 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0034 0.0441 0.0961
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0031 0.0393 0.2124
Brugia malayi Associated with TFs and helicases family protein 0.0012 0.0038 0.0083
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0119 0.2038 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0021 0.0206 0.0256
Loa Loa (eye worm) hypothetical protein 0.0034 0.0441 0.055
Loa Loa (eye worm) hypothetical protein 0.0012 0.0038 0.0046
Leishmania major lysyl-tRNA synthetase, putative 0.0023 0.0232 0.0827
Trypanosoma cruzi sugar transporter, putative 0.0014 0.0075 0.0363
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0031 0.0393 0.2124
Trypanosoma brucei glucose transporter, putative 0.0032 0.0398 0.1667
Plasmodium falciparum calcium-dependent protein kinase 5 0.0031 0.0391 0.045
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0119 0.2038 1
Echinococcus multilocularis solute carrier family 22 0.0014 0.0075 0.0037
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0398 0.2151
Loa Loa (eye worm) hypothetical protein 0.0014 0.0075 0.0093
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0398 0.1947
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0014 0.007 0.1397
Brugia malayi glutathione reductase 0.004 0.0563 0.1229
Schistosoma mansoni smad 0.0015 0.0092 0.0091
Entamoeba histolytica cysteine protease, putative 0.0016 0.0109 0.1253
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0102 0.1711 0.1679
Loa Loa (eye worm) hypothetical protein 0.0014 0.0075 0.0093
Toxoplasma gondii ABC1 family protein 0.0034 0.0441 0.0783
Trypanosoma cruzi GUP1, putative 0.0043 0.0607 0.2974
Echinococcus granulosus cathepsin L cysteine protease 0.0016 0.0109 0.0072
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0109 0.1845 0.905
Echinococcus multilocularis Smad4 0.0015 0.0092 0.0054
Brugia malayi beta-lactamase family protein 0.0034 0.0441 0.0961
Echinococcus granulosus protein cysteine N palmitoyltransferase 0.0043 0.0607 0.0571
Entamoeba histolytica protein kinase, putative 0.0031 0.039 0.6191
Leishmania major glucose transporter/membrane transporter D2, putative 0.0032 0.0398 0.1667
Loa Loa (eye worm) Smad1 0.0015 0.0092 0.0114
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0034 0.0441 0.0981
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.004 0.0563 0.1306
Loa Loa (eye worm) transcription factor SMAD2 0.0223 0.3982 0.4982
Onchocerca volvulus 0.0031 0.0393 0.0781
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.0043 0.0607 0.0606
Brugia malayi Valyl-tRNA synthetase 0.0012 0.0038 0.0083
Plasmodium vivax lysine--tRNA ligase, putative 0.0023 0.0232 0.0293
Echinococcus multilocularis cathepsin L cysteine protease 0.0031 0.0393 0.0357
Brugia malayi Sugar transporter family protein 0.0014 0.0075 0.0164
Trichomonas vaginalis transmembrane protein nessy, putative 0.0043 0.0607 0.3403
Trypanosoma cruzi hypothetical protein, conserved 0.0034 0.0441 0.2157
Chlamydia trachomatis lysine--tRNA ligase 0.0023 0.0232 1
Echinococcus multilocularis sterol O acyltransferase 1 0.0438 0.7993 0.7985
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0031 0.0393 0.2124
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0031 0.0393 0.0453
Plasmodium vivax hypothetical protein, conserved 0.0012 0.0038 0.0047
Echinococcus multilocularis cathepsin L cysteine protease 0.0031 0.0393 0.0357
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.007 0.0336
Trypanosoma cruzi glucose transporter, putative 0.0014 0.0075 0.0363
Trypanosoma brucei glucose transporter 1E 0.0032 0.0398 0.1667
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0398 0.1947
Leishmania major cathepsin L-like protease 0.0031 0.0393 0.1644
Schistosoma mansoni lamin 0.0021 0.0206 0.0205
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0019 0.0168 0.0261
Brugia malayi hypothetical protein 0.0014 0.0075 0.0164
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.1711 0.1679
Onchocerca volvulus 0.0014 0.0075 0.0082
Echinococcus granulosus membrane bound acyltransferase:hhat 0.0043 0.0607 0.0571
Trypanosoma brucei hypothetical protein, conserved 0.0034 0.0441 0.1885
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0023 0.0232 0.1135
Onchocerca volvulus Cathepsin F homolog 0.0031 0.0393 0.0781
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0016 0.0109 0.0202
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0043 0.0607 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0119 0.2038 1
Leishmania major cysteine peptidase A (CPA) 0.0031 0.0393 0.1644
Echinococcus granulosus cathepsin L cysteine proteinase 0.0031 0.0393 0.0357
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0031 0.0393 0.2124
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0014 0.007 0.0087
Onchocerca volvulus 0.0014 0.0075 0.0082
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0014 0.0075 1
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0015 0.0092 0.0054
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.1549 0.1517
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0014 0.007 0.0152
Loa Loa (eye worm) hypothetical protein 0.0042 0.0594 0.0742
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0014 0.0075 0.0029
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0031 0.0393 0.049
Leishmania major glycerol uptake protein, putative 0.0043 0.0607 0.273
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0075 0.0223
Loa Loa (eye worm) hypothetical protein 0.0014 0.0075 0.0093
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0014 0.007 0.0032
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0075 0.0223
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0021 0.02 0.0966
Plasmodium vivax CDK-related protein kinase 6, putative 0.0432 0.7884 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0042 0.0594 0.0559
Onchocerca volvulus 0.0031 0.0393 0.0781
Plasmodium vivax thioredoxin reductase, putative 0.004 0.0563 0.0713
Trypanosoma cruzi cysteine peptidase, putative 0.0119 0.2038 1
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0366 0.1962
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.1549 0.1517
Echinococcus granulosus solute carrier family 22 0.0014 0.0075 0.0037
Brugia malayi Hhat protein 0.0043 0.0607 0.1324
Onchocerca volvulus 0.0014 0.0075 0.0082
Loa Loa (eye worm) sugar transporter 0.0014 0.0075 0.0093
Giardia lamblia Sugar-proton symporter 0.0014 0.0075 0.0183
Trypanosoma cruzi hypothetical protein, conserved 0.0034 0.0441 0.2157
Trypanosoma cruzi cysteine peptidase, putative 0.0031 0.0393 0.1924
Mycobacterium tuberculosis Probable dehydrogenase 0.0092 0.1532 0.3865
Onchocerca volvulus 0.0014 0.0075 0.0082
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0031 0.0378 0.1351
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.007 0.0336
Schistosoma mansoni glucose transporter 0.0014 0.0075 0.0074
Onchocerca volvulus 0.0014 0.0075 0.0082
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0031 0.039 0.0354
Leishmania major cathepsin L-like protease 0.0031 0.0393 0.1644
Loa Loa (eye worm) hypothetical protein 0.0091 0.1508 0.1885
Trypanosoma brucei glucose transporter, putative 0.0032 0.0398 0.1667
Mycobacterium tuberculosis Conserved protein 0.0034 0.0441 0.0981
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0031 0.0378 0.5984
Mycobacterium tuberculosis Conserved protein 0.0034 0.0441 0.0981
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0398 0.2151
Brugia malayi Cathepsin L-like precursor 0.001 0.0001 0.0003
Onchocerca volvulus Cathepsin L homolog 0.0031 0.0393 0.0781
Echinococcus granulosus lamin 0.0021 0.0206 0.0169
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0075 0.0223
Echinococcus granulosus cathepsin l1 0.0021 0.02 0.0162
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0075 0.0223
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0031 0.039 0.0851
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0119 0.2038 1
Plasmodium vivax vivapain-3 0.0016 0.0109 0.0137
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0075 0.0223
Schistosoma mansoni hypothetical protein 0.0042 0.0594 0.0593
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0031 0.0393 0.2124
Loa Loa (eye worm) cysteine protease 0.0031 0.0393 0.049
Loa Loa (eye worm) hypothetical protein 0.0043 0.0607 0.0758
Giardia lamblia Hexose transporter 0.0014 0.0075 0.0183
Leishmania major glycerol uptake protein, putative 0.0043 0.0607 0.273
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0016 0.0109 0.0108
Trypanosoma cruzi glycerol uptake protein, putative 0.0043 0.0607 0.2974
Plasmodium vivax calcium-dependent protein kinase, putative 0.0031 0.0391 0.0494
Brugia malayi Papain family cysteine protease containing protein 0.0031 0.0393 0.0858
Schistosoma mansoni sugar transporter 0.0014 0.0075 0.0074
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0014 0.007 0.1397
Brugia malayi Cathepsin L-like precursor 0.0031 0.0393 0.0858
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0031 0.0391 0.0494
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0031 0.0378 0.0826
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0103 0.1724 1
Trichomonas vaginalis chromobox protein, putative 0.0075 0.1215 0.7037
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0031 0.0393 0.2124
Mycobacterium ulcerans sugar transporter 0.0014 0.0075 0.1528
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0031 0.0391 0.0494
Leishmania major cathepsin L-like protease 0.0031 0.0393 0.1644
Trypanosoma cruzi cysteine peptidase, putative 0.0119 0.2038 1
Leishmania major trypanothione reductase 0.004 0.0563 0.2509
Echinococcus multilocularis diacylglycerol O acyltransferase 1 0.0043 0.0607 0.0571
Trichomonas vaginalis CAMK family protein kinase 0.0031 0.039 0.2107
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0031 0.0393 0.0357
Echinococcus multilocularis mothers against decapentaplegic 5 0.0015 0.0092 0.0054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0119 0.2038 1
Echinococcus granulosus intermediate filament protein 0.0021 0.0206 0.0169
Echinococcus multilocularis smad 0.0015 0.0092 0.0054
Brugia malayi Cathepsin L-like precursor 0.0031 0.0393 0.0858
Loa Loa (eye worm) hypothetical protein 0.0031 0.0378 0.0472
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0043 0.0607 0.0571
Echinococcus multilocularis lysophospholipid acyltransferase 7 0.0043 0.0607 0.0571
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0075 0.0223
Loa Loa (eye worm) hypothetical protein 0.0034 0.0441 0.055
Onchocerca volvulus 0.0014 0.0075 0.0082
Trypanosoma cruzi glycerol uptake protein, putative 0.0043 0.0607 0.2974
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0596 0.3339
Leishmania major cathepsin L-like protease 0.0031 0.0393 0.1644
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0216 0.3852 1
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0378 0.0377
Echinococcus multilocularis beta LACTamase domain containing family member 0.0034 0.0441 0.0404
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0014 0.007 0.0068
Plasmodium falciparum lysine--tRNA ligase 0.0023 0.0232 0.0248
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0075 0.0223
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.0075 0.0093
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0075 0.0223
Brugia malayi Heterochromatin protein 1 0.0075 0.1215 0.265
Loa Loa (eye worm) fibroinase 0.0031 0.0393 0.049
Brugia malayi beta-lactamase family protein 0.0034 0.0441 0.0961
Echinococcus multilocularis lamin dm0 0.0021 0.0206 0.0169
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0093 0.1549 0.338
Echinococcus granulosus General substrate transporter 0.0087 0.1443 0.141
Brugia malayi Sugar transporter family protein 0.0014 0.0075 0.0164
Entamoeba histolytica cysteine protease, putative 0.0016 0.0109 0.1253
Trypanosoma cruzi hexose transporter, putative 0.0017 0.013 0.0633
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0075 0.0223
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.039 0.0354
Onchocerca volvulus 0.0014 0.0075 0.0082
Echinococcus multilocularis synaptic vesicle 2 protein 0.0014 0.0075 0.0037
Loa Loa (eye worm) hypothetical protein 0.0014 0.0075 0.0093
Plasmodium falciparum mitogen-activated protein kinase 2 0.0164 0.2883 0.3625
Loa Loa (eye worm) hypothetical protein 0.0014 0.0075 0.0093
Entamoeba histolytica hypothetical protein 0.0043 0.0607 1
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0102 0.1711 0.1679
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.1549 0.1517
Plasmodium vivax hypothetical protein, conserved 0.0034 0.0441 0.0558
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0378 0.0377
Toxoplasma gondii cathepsin CPL 0.0031 0.0393 0.069
Trichomonas vaginalis D-aminoacylase, putative 0.0034 0.0441 0.2408
Schistosoma mansoni protein kinase 0.0031 0.039 0.0389
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0031 0.0393 0.2124
Trypanosoma brucei glucose transporter, putative 0.0032 0.0398 0.1667
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0023 0.0232 0.0412
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0075 0.0223
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0075 0.0223
Brugia malayi MH2 domain containing protein 0.0223 0.3982 0.8687
Schistosoma mansoni chromobox protein 0.0075 0.1215 0.1214
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0075 0.0223
Entamoeba histolytica hypothetical protein, conserved 0.0043 0.0607 1
Echinococcus multilocularis chromobox protein 1 0.0075 0.1215 0.1181
Mycobacterium ulcerans hypothetical protein 0.0034 0.0441 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0041 0.0574 0.0538
Brugia malayi latrophilin 2 splice variant baaae 0.0091 0.1508 0.3289
Trypanosoma brucei glycerol uptake protein, putative 0.0043 0.0607 0.273
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0012 0.0038 0.0037
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0031 0.0393 0.2124
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0119 0.2038 1
Plasmodium vivax vivapain-1 0.0016 0.0109 0.0137
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0031 0.0378 0.2036
Trypanosoma cruzi hexose transporter, putative 0.0014 0.0075 0.0363
Trypanosoma cruzi cysteine proteinase, putative 0.0016 0.0109 0.053
Loa Loa (eye worm) hypothetical protein 0.0438 0.7993 1
Entamoeba histolytica hypothetical protein 0.0023 0.0232 0.3416
Schistosoma mansoni glucose transport protein 0.0102 0.1711 0.171
Loa Loa (eye worm) sugar transporter 0.0102 0.1711 0.2139
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0014 0.007 0.004
Mycobacterium leprae conserved hypothetical protein 0.0034 0.0441 0.1751
Onchocerca volvulus 0.0014 0.0075 0.0082
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0232 0.5171
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0075 0.0223
Onchocerca volvulus 0.0031 0.0393 0.0781
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0075 0.0223
Toxoplasma gondii sugar transporter ST3 0.0014 0.0075 0.0072
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.039 0.0354
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0232 0.0231
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.1549 0.1548
Schistosoma mansoni microtubule-associated protein tau 0.0545 1 1
Plasmodium falciparum proline--tRNA ligase 0.0036 0.0473 0.0555
Plasmodium falciparum cysteine proteinase falcipain 1 0.0016 0.0109 0.0091
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.007 0.0336
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0596 0.1229
Onchocerca volvulus 0.0034 0.0441 0.0886
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0075 0.0223
Mycobacterium leprae Probable lipase LipE 0.0034 0.0441 0.1751
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0011 0.0021 0.0025
Toxoplasma gondii sugar transporter ST1 0.0014 0.0075 0.0072
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0596 0.3339
Brugia malayi MBOAT family protein 0.0043 0.0607 0.1324
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.1549 0.1548
Brugia malayi chromobox protein homolog 3 0.0042 0.0596 0.1301
Onchocerca volvulus 0.0255 0.4584 1
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0075 0.0223
Loa Loa (eye worm) CHromoDomain protein family member 0.0012 0.0038 0.0046
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0031 0.0393 0.2124
Trypanosoma brucei trypanothione reductase 0.004 0.0563 0.2509
Brugia malayi cytoplasmic intermediate filament protein 0.0011 0.0021 0.0046
Loa Loa (eye worm) intermediate filament protein 0.0021 0.0206 0.0256
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0042 0.0594 0.1297
Plasmodium falciparum thioredoxin reductase 0.004 0.0563 0.067
Plasmodium falciparum diacylglycerol O-acyltransferase 0.0043 0.0607 0.0725
Entamoeba histolytica cysteine proteinase 1, putative 0.0016 0.0109 0.1253
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0398 0.2151
Trypanosoma cruzi cysteine peptidase, putative 0.0119 0.2038 1
Leishmania major myo-inositol/proton symporter (MIT) 0.0014 0.0075 0.0029
Schistosoma mansoni lamin 0.0021 0.0206 0.0205
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.1711 0.1679
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0398 0.1667
Schistosoma mansoni sugar transporter 0.0014 0.0075 0.0074
Schistosoma mansoni sterol O-acyltransferase 1 0.0438 0.7993 0.7993
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.1549 0.1517
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0042 0.0594 0.0559
Echinococcus granulosus GPCR family 2 0.0042 0.0594 0.0559
Echinococcus multilocularis protein cysteine N palmitoyltransferase 0.0043 0.0607 0.0571
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0119 0.2038 1
Plasmodium falciparum glutathione reductase 0.0014 0.007 0.004
Loa Loa (eye worm) MBOAT family protein 0.0043 0.0607 0.0758
Loa Loa (eye worm) hypothetical protein 0.0014 0.0075 0.0093
Echinococcus granulosus sterol O acyltransferase 1 0.0438 0.7993 0.7985
Entamoeba histolytica cysteine proteinase, putative 0.0031 0.0393 0.624
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0014 0.0075 0.0015
Trypanosoma brucei glucose transporter 2A 0.0032 0.0398 0.1667
Brugia malayi M-phase phosphoprotein, mpp8 0.0012 0.0038 0.0083
Brugia malayi CHD4 protein 0.0012 0.0038 0.0083
Schistosoma mansoni hypothetical protein 0.0042 0.0594 0.0593
Entamoeba histolytica vacuolar protein sorting 26 0.0043 0.0607 1
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0019 0.0168 0.0261
Entamoeba histolytica cysteine protease, putative 0.0016 0.0109 0.1253
Echinococcus granulosus beta LACTamase domain containing family member 0.0034 0.0441 0.0404
Echinococcus granulosus thioredoxin glutathione reductase 0.0041 0.0574 0.0538
Mycobacterium tuberculosis Probable reductase 0.0092 0.1532 0.3865
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0014 0.007 0.004
Toxoplasma gondii hypothetical protein 0.0043 0.0607 0.1106
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.039 0.0354
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0075 0.0164
Leishmania major cathepsin L-like protease 0.0119 0.2038 1
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0075 0.0223
Mycobacterium tuberculosis Probable oxidoreductase 0.0103 0.1724 0.4374
Loa Loa (eye worm) MH2 domain-containing protein 0.0015 0.0092 0.0114
Toxoplasma gondii protein kinase, putative 0.0288 0.5184 1
Onchocerca volvulus 0.0014 0.0075 0.0082
Onchocerca volvulus 0.0021 0.02 0.0355
Brugia malayi Cathepsin L-like precursor 0.0021 0.02 0.0435
Trichomonas vaginalis penicillin-binding protein, putative 0.0034 0.0441 0.2408
Schistosoma mansoni intermediate filament proteins 0.0021 0.0206 0.0205
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0075 0.0223
Loa Loa (eye worm) hypothetical protein 0.0021 0.0199 0.0247
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0473 0.205
Plasmodium vivax glutathione reductase, putative 0.004 0.0563 0.0713
Echinococcus multilocularis GPCR, family 2 0.0042 0.0594 0.0559
Brugia malayi Calcitonin receptor-like protein seb-1 0.0133 0.2295 0.5005
Loa Loa (eye worm) hypothetical protein 0.0043 0.0607 0.0758
Brugia malayi beta-lactamase 0.0034 0.0441 0.0961
Plasmodium falciparum calcium-dependent protein kinase 2 0.0031 0.0391 0.045
Echinococcus granulosus smad 0.0015 0.0092 0.0054
Toxoplasma gondii sugar transporter ST2 0.0014 0.0075 0.0072
Schistosoma mansoni smad1 5 8 and 0.0015 0.0092 0.0091
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0075 0.0223
Echinococcus multilocularis cathepsin L 0.0016 0.0109 0.0072
Echinococcus multilocularis musashi 0.0021 0.0206 0.0169
Onchocerca volvulus 0.0014 0.0075 0.0082
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0042 0.0594 0.0559
Leishmania major hypothetical protein, conserved 0.0043 0.0607 0.273
Leishmania major cathepsin L-like protease 0.0119 0.2038 1
Brugia malayi MBOAT family protein 0.0043 0.0607 0.1324
Brugia malayi MH2 domain containing protein 0.0015 0.0092 0.0201
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0075 0.0223
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0023 0.0232 0.0827
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0034 0.0441 0.044
Trypanosoma brucei glucose transporter, putative 0.0032 0.0398 0.1667
Loa Loa (eye worm) hypothetical protein 0.0014 0.0075 0.0093
Entamoeba histolytica cysteine proteinase, putative 0.0021 0.02 0.284
Onchocerca volvulus 0.0021 0.0206 0.0369
Brugia malayi MH1 domain containing protein 0.0015 0.0092 0.0201
Schistosoma mansoni Smad4 0.0015 0.0092 0.0091
Loa Loa (eye worm) diacylglycerol acyltransferase 0.0043 0.0607 0.0758
Mycobacterium tuberculosis Probable esterase LipL 0.0034 0.0441 0.0981
Trichomonas vaginalis D-aminoacylase, putative 0.0034 0.0441 0.2408
Entamoeba histolytica protein kinase, putative 0.0031 0.039 0.6191
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0043 0.0607 1
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0036 0.0473 0.0846
Echinococcus granulosus synaptic vesicle 2 protein 0.0014 0.0075 0.0037
Trypanosoma brucei sugar transporter, putative 0.0014 0.0075 0.0029
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0021 0.02 0.0966
Loa Loa (eye worm) hypothetical protein 0.0014 0.0075 0.0093
Leishmania major protein kinase, putative 0.0031 0.039 0.1629
Trypanosoma cruzi trypanothione reductase, putative 0.004 0.0563 0.276
Loa Loa (eye worm) thioredoxin reductase 0.004 0.0563 0.0704
Onchocerca volvulus 0.0014 0.0075 0.0082
Brugia malayi Sugar transporter family protein 0.0102 0.1711 0.3731
Loa Loa (eye worm) hypothetical protein 0.0021 0.02 0.0248
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0092 0.1532 0.3865
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0109 0.1253
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0366 0.1962
Loa Loa (eye worm) hypothetical protein 0.0025 0.0271 0.0338
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0014 0.0075 0.0047
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.007 0.0336
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0102 0.1711 0.1679
Echinococcus granulosus calcium dependent protein kinase 0.0029 0.0354 0.0318
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.0075 0.0093
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0016 0.0109 0.053
Trypanosoma cruzi cysteine proteinase, putative 0.0016 0.0109 0.053
Brugia malayi MH2 domain containing protein 0.0015 0.0092 0.0201
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha 0.0043 0.0607 0.1106
Trichomonas vaginalis mercuric reductase, putative 0.0014 0.007 0.0189
Plasmodium falciparum calcium-dependent protein kinase 4 0.0031 0.0391 0.045
Loa Loa (eye worm) MBOAT family protein 0.0043 0.0607 0.0758
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0014 0.007 0.0061
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.1711 0.1679
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0043 0.0607 0.0606
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0031 0.039 0.1629
Brugia malayi SET domain containing protein 0.0012 0.0038 0.0083
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0031 0.0393 0.2124
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0607 0.3403
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0092 0.1532 0.8763
Leishmania major glycerol uptake protein, putative 0.0043 0.0607 0.273
Entamoeba histolytica cysteine protease, putative 0.0016 0.0109 0.1253
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0109 0.1253
Trypanosoma cruzi cruzipain precursor, putative 0.0119 0.2038 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0109 0.0426
Onchocerca volvulus 0.0031 0.0393 0.0781
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0092 0.1532 0.3865
Brugia malayi major facilitator superfamily protein 0.0014 0.0075 0.0164
Loa Loa (eye worm) ctsf protein 0.0031 0.0393 0.049
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0031 0.0391 0.0685
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0034 0.0441 0.044
Schistosoma mansoni membrane-bound acyltransferase/hhat 0.0043 0.0607 0.0606
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.007 0.0336
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0031 0.0393 0.0357
Loa Loa (eye worm) hhat protein 0.0043 0.0607 0.0758
Entamoeba histolytica cysteine protease, putative 0.0016 0.0109 0.1253
Schistosoma mansoni smad1 5 8 and 0.0015 0.0092 0.0091
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0398 0.2151
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0042 0.0594 0.0559
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0012 0.0038 0.0037
Loa Loa (eye worm) hypothetical protein 0.0014 0.0075 0.0093
Onchocerca volvulus 0.0043 0.0607 0.1252
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0109 0.1253
Entamoeba histolytica cysteine proteinase, putative 0.0031 0.0393 0.624
Loa Loa (eye worm) pax transcription factor protein 2 0.0255 0.4584 0.5735
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0034 0.0441 0.0981
Echinococcus multilocularis General substrate transporter 0.0087 0.1443 0.141
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0075 0.0223
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0119 0.2038 1
Echinococcus granulosus solute carrier family 22 0.0014 0.0075 0.0037
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0075 0.0223
Brugia malayi Cathepsin L-like cysteine proteinase 0.0021 0.02 0.0435
Plasmodium vivax diacylglycerol O-acyltransferase, putative 0.0043 0.0607 0.0769
Onchocerca volvulus Putative transporter 0.0014 0.0075 0.0082
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0075 0.0164
Loa Loa (eye worm) hypothetical protein 0.0034 0.0441 0.055
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0075 0.0223
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0075 0.0223
Echinococcus granulosus chromobox protein 1 0.0075 0.1215 0.1181
Onchocerca volvulus 0.0014 0.0075 0.0082
Brugia malayi Cam kinase protein 1 0.0031 0.039 0.0851
Trichomonas vaginalis glutathione reductase, putative 0.0014 0.007 0.0189
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0075 0.0223
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0075 0.0223
Trichomonas vaginalis myo-inositol transporter, putative 0.0014 0.0075 0.0223
Onchocerca volvulus 0.0031 0.0393 0.0781
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0031 0.0393 0.2124
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0014 0.007 0.2701
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0119 0.2038 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0031 0.0393 0.2124
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0031 0.0393 0.2124
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0031 0.0391 0.0685
Schistosoma mansoni hypothetical protein 0.0042 0.0594 0.0593
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0031 0.0393 0.2124
Echinococcus granulosus cathepsin l cysteine peptidase 0.0031 0.0393 0.0357
Treponema pallidum alginate O-acetylation protein (algI) 0.0043 0.0607 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0031 0.0393 0.2124
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0031 0.0378 0.0826
Mycobacterium ulcerans beta-lactamase 0.0034 0.0441 1
Echinococcus granulosus o acyltransferase membrane bound domain 0.0043 0.0607 0.0571
Echinococcus granulosus lysophospholipid acyltransferase 7 0.0043 0.0607 0.0571
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0473 0.205
Loa Loa (eye worm) glutathione reductase 0.004 0.0563 0.0704
Loa Loa (eye worm) hypothetical protein 0.0014 0.0075 0.0093
Trichomonas vaginalis penicillin-binding protein, putative 0.0034 0.0441 0.2408
Plasmodium falciparum calcium-dependent protein kinase 1 0.0031 0.0391 0.045
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0031 0.0393 0.2124
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0075 0.0223
Schistosoma mansoni sugar transporter 0.0014 0.0075 0.0074
Loa Loa (eye worm) hypothetical protein 0.0021 0.02 0.0248
Loa Loa (eye worm) hypothetical protein 0.0034 0.0441 0.055
Echinococcus granulosus Sugar transporter ERD6 protein 0.0014 0.0075 0.0037
Mycobacterium ulcerans integral membrane transport protein 0.0014 0.0075 0.1528
Onchocerca volvulus 0.0033 0.0426 0.0854
Entamoeba histolytica cysteine protease, putative 0.0031 0.0393 0.624
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0013 0.0042 0.0051
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0473 0.2316
Entamoeba histolytica cysteine protease, putative 0.0016 0.0109 0.1253
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0398 0.2151
Loa Loa (eye worm) hypothetical protein 0.0014 0.0075 0.0093
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0015 0.0092 0.0091
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0012 0.0038 0.0037
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0075 0.0223
Onchocerca volvulus 0.0034 0.0441 0.0886
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0133 0.2295 0.287
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0012 0.0038 0.0037
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.039 0.0354
Trypanosoma brucei glucose transporter, putative 0.0032 0.0398 0.1667
Loa Loa (eye worm) hypothetical protein 0.0012 0.0038 0.0046
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0014 0.0075 0.0015
Onchocerca volvulus 0.0014 0.0075 0.0082
Schistosoma mansoni serine/threonine protein kinase 0.0031 0.039 0.0389
Schistosoma mansoni hypothetical protein 0.0102 0.1711 0.171
Schistosoma mansoni leukocyte receptor cluster (lrc) member 4 protein 0.0043 0.0607 0.0606
Schistosoma mansoni hypothetical protein 0.0042 0.0594 0.0593
Mycobacterium tuberculosis Probable lipase LipE 0.0034 0.0441 0.0981
Trichomonas vaginalis D-aminoacylase, putative 0.0034 0.0441 0.2408
Echinococcus multilocularis cysteine protease 0.0031 0.0393 0.0357
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0043 0.0607 0.0571
Echinococcus granulosus cathepsin L 0.0016 0.0109 0.0072
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0398 0.1667
Loa Loa (eye worm) membrane bound O-acyltransferase domain containing 1 0.0043 0.0607 0.0758
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0045 0.0656 0.136
Loa Loa (eye worm) hypothetical protein 0.0034 0.0441 0.055
Trypanosoma cruzi major cysteine proteinase, putative 0.0094 0.1561 0.7656
Brugia malayi major facilitator superfamily protein 0.0014 0.0075 0.0164
Brugia malayi diacylglycerol acyltransferase 0.0043 0.0607 0.1324
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0473 0.2316
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.039 0.0354
Loa Loa (eye worm) hypothetical protein 0.0042 0.0596 0.0745
Loa Loa (eye worm) helicase 0.0012 0.0038 0.0046
Brugia malayi MBOAT family protein 0.0043 0.0607 0.1324
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0102 0.1711 0.1679
Giardia lamblia Lysyl-tRNA synthetase 0.0023 0.0232 0.527
Brugia malayi Cathepsin L-like precursor 0.0031 0.0393 0.0858
Entamoeba histolytica cysteine protease, putative 0.0016 0.0109 0.1253
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0034 0.0441 0.055
Plasmodium vivax hexose transporter 0.0102 0.1711 0.2168
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0109 0.1253
Loa Loa (eye worm) hypothetical protein 0.0012 0.0038 0.0046
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0075 0.0223
Brugia malayi cathepsin L-like precursor 0.0021 0.02 0.0435
Echinococcus granulosus solute carrier family 22 0.0014 0.0075 0.0037
Onchocerca volvulus Cathepsin L homolog 0.0031 0.0393 0.0781
Echinococcus granulosus o acyltransferase membrane bound domain 0.0043 0.0607 0.0571
Schistosoma mansoni chromobox protein 0.0012 0.0038 0.0037
Echinococcus granulosus Smad4 0.0015 0.0092 0.0054
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0075 0.0223
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0398 0.2151
Onchocerca volvulus 0.0014 0.0075 0.0082
Leishmania major hypothetical protein, conserved 0.0034 0.0441 0.1885
Echinococcus granulosus chromobox protein 1 0.0075 0.1215 0.1181
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.1711 0.1679
Loa Loa (eye worm) hypothetical protein 0.0031 0.0378 0.0472
Schistosoma mansoni glucose transport protein 0.0102 0.1711 0.171
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0014 0.007 0.0087
Loa Loa (eye worm) hypothetical protein 0.0012 0.0038 0.0046
Leishmania major cathepsin L-like protease 0.0031 0.0393 0.1644
Schistosoma mansoni hypothetical protein 0.0091 0.1508 0.1507
Leishmania major glucose transporter, lmgt2 0.0032 0.0398 0.1667
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0075 0.0223
Loa Loa (eye worm) hypothetical protein 0.0031 0.0393 0.049
Brugia malayi Latrophilin receptor protein 2 0.0042 0.0594 0.1297

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 310 nM Agonist activity at human recombinant adrenergic beta3 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assay ChEMBL. 20833036
Efficacy (functional) = 2.8 % Agonist activity at human recombinant adrenergic beta3 receptor expressed in CHO cells assessed as cyclic AMP formation response equal to 25% of maximum response achieved with 100 uM of isoproterenol by HTRF assay ChEMBL. 20833036
Ki (binding) = 3500 nM Displacement of [125I]-cyanopindolol from human adrenergic beta3 receptor expressed in CHO cells ChEMBL. 20833036
Ki (binding) = 6710 nM Displacement of [125I]-cyanopindolol from human adrenergic beta-1 receptor expressed in CHO cells ChEMBL. 20833036

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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