Detailed information for compound 1261074

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 428.569 | Formula: C27H32N4O
  • H donors: 0 H acceptors: 2 LogP: 4.17 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1CCc2c(N1C)ccc(c2CCN1CCN(CC1)c1cccc2c1ccc(n2)C)C
  • InChi: 1S/C27H32N4O/c1-19-7-11-25-22(10-12-27(32)29(25)3)21(19)13-14-30-15-17-31(18-16-30)26-6-4-5-24-23(26)9-8-20(2)28-24/h4-9,11H,10,12-18H2,1-3H3
  • InChiKey: PDLXDQOODGXTSQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens potassium voltage-gated channel, subfamily H (eag-related), member 2 References
Homo sapiens 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled Starlite/ChEMBL References
Homo sapiens v-ets avian erythroblastosis virus E26 oncogene homolog Starlite/ChEMBL References
Homo sapiens 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled Starlite/ChEMBL References
Homo sapiens solute carrier family 6 (neurotransmitter transporter), member 4 Starlite/ChEMBL References
Homo sapiens 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) solute carrier family 6 member 4 Get druggable targets OG5_128364 All targets in OG5_128364
Echinococcus granulosus serotonin transporter Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
Echinococcus granulosus biogenic amine 5HT receptor Get druggable targets OG5_133249 All targets in OG5_133249
Loa Loa (eye worm) fli-1 protein Get druggable targets OG5_131947 All targets in OG5_131947
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133680 All targets in OG5_133680
Schistosoma japonicum ko:K04910 potassium voltage-gated channel, Eag-related subfamily H, member 7, putative Get druggable targets OG5_128858 All targets in OG5_128858
Loa Loa (eye worm) voltage and ligand gated potassium channel Get druggable targets OG5_128858 All targets in OG5_128858
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_141128 All targets in OG5_141128
Schistosoma mansoni ets-related Get druggable targets OG5_131947 All targets in OG5_131947
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133249 All targets in OG5_133249
Onchocerca volvulus Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Potassium voltage-gated channel subfamily H member 2, putative Get druggable targets OG5_128858 All targets in OG5_128858
Schistosoma japonicum ko:K04153 5-hydroxytryptamine (serotonin) receptor 1A, putative Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma mansoni biogenic amine (5HT) receptor Get druggable targets OG5_133249 All targets in OG5_133249
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128858 All targets in OG5_128858
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor Get druggable targets OG5_141128 All targets in OG5_141128
Loa Loa (eye worm) serotonin transporter b Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum ko:K05336 solute carrier family 6 (neurotransmitter transporter), invertebrate, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Octopamine receptor, putative Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma japonicum 5-hydroxytryptamine receptor, putative Get druggable targets OG5_133680 All targets in OG5_133680
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_141128 All targets in OG5_141128
Echinococcus multilocularis serotonin transporter Get druggable targets OG5_128364 All targets in OG5_128364
Brugia malayi Fli-1 protein Get druggable targets OG5_131947 All targets in OG5_131947
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum ko:K09435 transcriptional regulator ERG, putative Get druggable targets OG5_131947 All targets in OG5_131947
Treponema pallidum sodium- and chloride- dependent transporter Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent noradrenaline transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Echinococcus granulosus potassium voltage gated channel subfamily H Get druggable targets OG5_128858 All targets in OG5_128858
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133249 All targets in OG5_133249
Trichomonas vaginalis voltage and ligand gated potassium channel, putative Get druggable targets OG5_128858 All targets in OG5_128858
Brugia malayi Serotonin/octopamine receptor family protein 7 Get druggable targets OG5_141128 All targets in OG5_141128
Echinococcus multilocularis serotonin receptor Get druggable targets OG5_133249 All targets in OG5_133249
Echinococcus multilocularis potassium voltage gated channel subfamily H Get druggable targets OG5_128858 All targets in OG5_128858
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Echinococcus multilocularis serotonin receptor Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Brugia malayi Sodium:neurotransmitter symporter family protein Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum IPR000175,Sodium:neurotransmitter symporter,domain-containing Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma mansoni sodium/chloride dependent transporter Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum ko:K04165 Oamb gene product from transcript, putative Get druggable targets OG5_141128 All targets in OG5_141128
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog Get druggable targets OG5_128858 All targets in OG5_128858
Schistosoma mansoni voltage-gated potassium channel Get druggable targets OG5_128858 All targets in OG5_128858
Schistosoma mansoni norepinephrine/norepinephrine transporter Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) norepinephrine transporter Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum expressed protein Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma mansoni voltage-gated potassium channel Get druggable targets OG5_128858 All targets in OG5_128858
Schistosoma japonicum ko:K04910 potassium voltage-gated channel, Eag-related subfamily H, member 7, putative Get druggable targets OG5_128858 All targets in OG5_128858
Trichomonas vaginalis voltage and ligand gated potassium channel, putative Get druggable targets OG5_128858 All targets in OG5_128858
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi AT19640p 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled 390 aa 335 aa 21.8 %
Brugia malayi Sodium:neurotransmitter symporter family protein solute carrier family 6 (neurotransmitter transporter), member 4 630 aa 574 aa 31.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi serine carboxypeptidase S28, putative 0.0102 0.0269 0.2622
Trypanosoma cruzi putative prolyl carboxypeptidase, putative 0.0102 0.0269 0.2622
Leishmania major alpha glucosidase II subunit, putative 0.0037 0.0071 0.0688
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0082 0.0209 0.2032
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.002 0.0034
Trichomonas vaginalis prolylcarboxypeptidase, putative 0.0102 0.0269 0.1813
Toxoplasma gondii prolyl endopeptidase 0.0082 0.0209 0.2032
Entamoeba histolytica acyl-coA synthetase, putative 0.0048 0.0105 0.1385
Loa Loa (eye worm) hypothetical protein 0.0039 0.0077 0.0246
Mycobacterium ulcerans lipase LipD 0.0118 0.0319 0.0747
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0102 0.0269 0.1813
Echinococcus granulosus neuropeptide receptor A26 0.0466 0.1389 0.2402
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0048 0.0104 0.018
Echinococcus granulosus intermediate filament protein 0.0026 0.0037 0.0064
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0004 0.0044
Brugia malayi ecdysteroid receptor 0.0021 0.002 0.0063
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0082 0.0209 0.2032
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0015 0.0149
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0075 0.0186 0.1815
Echinococcus granulosus FTZ F1 alpha 0.0021 0.002 0.0034
Plasmodium falciparum ataxin-2 like protein, putative 0.0107 0.0286 1
Echinococcus multilocularis acylamino acid releasing enzyme 0.0082 0.0209 0.0209
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.002 0.0034
Plasmodium falciparum acyl-CoA synthetase 0.0036 0.0068 0.2364
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0004 0.0044
Loa Loa (eye worm) prolyl oligopeptidase 0.0082 0.0209 0.0664
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.0016 0.0006 0.0018
Schistosoma mansoni ap endonuclease 0.0019 0.0015 0.0026
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.0016 0.0006 0.0018
Brugia malayi prolyl oligopeptidase family protein 0.0082 0.0209 0.0664
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0118 0.0319 0.1014
Mycobacterium ulcerans transcriptional regulator 0.1403 0.4265 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.002 0.0063
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0016 0.0006 0.001
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0071 0.0476
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0015 0.0201
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0015 0.0103
Brugia malayi RNA recognition motif domain containing protein 0.0202 0.0577 0.1837
Schistosoma mansoni tar DNA-binding protein 0.0202 0.0577 0.0998
Mycobacterium ulcerans hypothetical protein 0.0118 0.0319 0.0747
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0015 0.0026
Trypanosoma brucei prolyl oligopeptidase, putative 0.0082 0.0209 0.2032
Schistosoma mansoni biogenic amine (5HT) receptor 0.0158 0.0442 0.0764
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0118 0.0319 0.0747
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.0016 0.0006 0.0018
Plasmodium vivax acyl-CoA synthetase, putative 0.0036 0.0068 0.2121
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0004 0.0004
Mycobacterium tuberculosis Conserved protein 0.0118 0.0319 0.0747
Echinococcus granulosus tumor protein p63 0.0679 0.2041 0.3529
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.002 0.0034
Trichomonas vaginalis GTP-binding protein (q) alpha-11 subunit, gna11, putative 0.0016 0.0006 0.0039
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.0071 0.0225
Loa Loa (eye worm) hypothetical protein 0.0368 0.1087 0.346
Echinococcus multilocularis lysosomal alpha glucosidase 0.0168 0.0472 0.0472
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0015 0.0036
Onchocerca volvulus 0.0102 0.0269 0.0857
Loa Loa (eye worm) prolyl oligopeptidase 0.1037 0.3142 1
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0017 0.0008 0.0079
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.0016 0.0006 0.001
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0075 0.0186 0.1815
Trichomonas vaginalis esterase, putative 0.0118 0.0319 0.2144
Schistosoma mansoni ets-related 0.0265 0.0772 0.1335
Echinococcus multilocularis serotonin transporter 0.0073 0.018 0.018
Brugia malayi nuclear receptor NHR-88 0.0021 0.002 0.0063
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0071 0.0476
Loa Loa (eye worm) hypothetical protein 0.0016 0.0006 0.0018
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0015 0.0149
Schistosoma mansoni thyroid hormone receptor 0.0021 0.002 0.0034
Toxoplasma gondii serine carboxypeptidase s28 protein 0.0102 0.0269 0.2622
Brugia malayi latrophilin 2 splice variant baaae 0.0206 0.059 0.1879
Trichomonas vaginalis G protein (olf) alpha subunit, gnal, putative 0.0016 0.0006 0.0039
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0045 0.0093 0.0093
Entamoeba histolytica serine carboxypeptidase (S28) family protein 0.0102 0.0269 0.3545
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.0016 0.0006 0.0018
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.002 0.0034
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0063
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0105 0.0335
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0048 0.0104 0.0104
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0262 0.076 0.076
Loa Loa (eye worm) hypothetical protein 0.0048 0.0105 0.0335
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0004 0.0044
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0016 0.0006 0.0006
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.002 0.0063
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0082 0.0209 0.1405
Loa Loa (eye worm) hypothetical protein 0.0073 0.018 0.0574
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.0016 0.0006 0.0018
Brugia malayi hypothetical protein 0.0262 0.076 0.2418
Loa Loa (eye worm) hypothetical protein 0.0118 0.0319 0.1014
Schistosoma mansoni gabp alpha 0.0087 0.0225 0.0389
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.002 0.0034
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0008 0.0055
Echinococcus multilocularis serotonin receptor 0.0158 0.0442 0.0442
Plasmodium vivax hypothetical protein, conserved 0.0082 0.0209 0.6553
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0368 0.1087 0.346
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.002 0.0063
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0015 0.0103
Trichomonas vaginalis conserved hypothetical protein 0.0082 0.0209 0.1405
Schistosoma mansoni hypothetical protein 0.0262 0.076 0.1314
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0016 0.0006 0.001
Schistosoma mansoni hypothetical protein 0.0096 0.025 0.0432
Loa Loa (eye worm) hypothetical protein 0.0159 0.0446 0.142
Echinococcus granulosus TGF beta signal transducer SmadC 0.0034 0.0059 0.0102
Brugia malayi hypothetical protein 0.0056 0.0129 0.0411
Brugia malayi Inositol-1 0.0075 0.0186 0.0593
Brugia malayi hypothetical protein 0.0266 0.0775 0.2466
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR 0.1403 0.4265 1
Schistosoma mansoni aryl hydrocarbon receptor 0.0017 0.0009 0.0016
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0437 0.13 0.4137
Brugia malayi MH1 domain containing protein 0.0034 0.0059 0.0188
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0061 0.0144
Trypanosoma brucei hypothetical protein, conserved 0.0118 0.0319 0.3101
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0071 0.0476
Schistosoma mansoni inositol monophosphatase 0.0075 0.0186 0.0322
Trichomonas vaginalis GTP-binding protein (z) alpha subunit, gnaz, putative 0.0016 0.0006 0.0039
Entamoeba histolytica prolyl oligopeptidase family protein 0.0082 0.0209 0.2748
Loa Loa (eye worm) nuclear factor I 0.0019 0.0013 0.0042
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0349 0.1027 1
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0082 0.0209 0.1405
Giardia lamblia Alanyl dipeptidyl peptidase 0.0082 0.0209 0.7616
Trichomonas vaginalis adenylate cyclase, putative 0.0017 0.0008 0.0055
Echinococcus granulosus prolyl endopeptidase 0.0082 0.0209 0.0361
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.002 0.0063
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.002 0.0034
Brugia malayi hypothetical protein 0.004 0.0078 0.0248
Echinococcus multilocularis geminin 0.0165 0.0464 0.0464
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0075 0.0186 0.1815
Loa Loa (eye worm) hypothetical protein 0.0048 0.0105 0.0335
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.004 0.0078 0.0248
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0349 0.1027 1
Schistosoma mansoni smad 0.0015 0.0002 0.0004
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0075 0.0186 0.0437
Echinococcus granulosus survival motor neuron protein 1 0.0712 0.2144 0.3708
Brugia malayi isocitrate dehydrogenase 0.0016 0.0004 0.0014
Echinococcus granulosus serotonin transporter 0.0073 0.018 0.0312
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0048 0.0105 0.0247
Echinococcus granulosus expressed protein 0.0016 0.0006 0.001
Loa Loa (eye worm) hypothetical protein 0.0073 0.018 0.0574
Echinococcus granulosus Dipeptidyl peptidase 9 0.0349 0.1027 0.1777
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0016 0.0006 0.0006
Onchocerca volvulus 0.0018 0.0012 0.0039
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.002 0.0063
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0105 0.0247
Brugia malayi Latrophilin receptor protein 2 0.0096 0.025 0.0795
Mycobacterium leprae Possible regulatory protein 0.0017 0.0008 0.0019
Loa Loa (eye worm) hypothetical protein 0.0056 0.0129 0.0411
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0048 0.0105 0.0247
Trypanosoma cruzi hypothetical protein, conserved 0.0082 0.0209 0.2032
Mycobacterium leprae Probable lipase LipE 0.0118 0.0319 0.0747
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0071 0.0476
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.0105 0.0247
Brugia malayi beta-lactamase family protein 0.0118 0.0319 0.1014
Brugia malayi PAS domain containing protein 0.0017 0.0008 0.0026
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0008 0.0055
Loa Loa (eye worm) inositol-1 0.0075 0.0186 0.0593
Loa Loa (eye worm) hypothetical protein 0.0158 0.0442 0.1406
Brugia malayi TAR-binding protein 0.0202 0.0577 0.1837
Schistosoma mansoni alpha glucosidase 0.0037 0.0071 0.0122
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0082 0.0209 0.2032
Loa Loa (eye worm) hypothetical protein 0.0026 0.0037 0.0118
Schistosoma mansoni GTP-binding protein alpha subunit 0.0016 0.0006 0.001
Schistosoma mansoni hypothetical protein 0.0096 0.025 0.0432
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0102 0.0269 0.1813
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0082 0.0209 0.0361
Loa Loa (eye worm) hypothetical protein 0.0082 0.0209 0.0664
Brugia malayi prolyl oligopeptidase family protein 0.0082 0.0209 0.0664
Echinococcus multilocularis neuropeptide s receptor 0.0466 0.1389 0.1389
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0082 0.0209 0.0361
Trypanosoma cruzi prolyl endopeptidase 0.0082 0.0209 0.2032
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.002 0.0034
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0262 0.076 0.1314
Brugia malayi aryl hydrocarbon receptor AHR-1 0.0039 0.0077 0.0246
Echinococcus granulosus GA binding protein alpha chain 0.0087 0.0225 0.0389
Loa Loa (eye worm) hypothetical protein 0.0039 0.0077 0.0246
Echinococcus multilocularis Lysosomal Pro X carboxypeptidase 0.0102 0.0269 0.0269
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0017 0.0008 0.0079
Trichomonas vaginalis set domain proteins, putative 0.0498 0.1486 1
Brugia malayi MH2 domain containing protein 0.0492 0.1467 0.4669
Trypanosoma brucei glucosidase, putative 0.0037 0.0071 0.0688
Loa Loa (eye worm) hypothetical protein 0.0118 0.0319 0.1014
Schistosoma mansoni hypothetical protein 0.0096 0.025 0.0432
Onchocerca volvulus 0.0159 0.0446 0.142
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0105 0.1024
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0075 0.0186 1
Leishmania major protein kinase, putative 0.0023 0.0026 0.0255
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0036 0.0068 1
Schistosoma mansoni nuclear hormone receptor 0.0021 0.002 0.0034
Loa Loa (eye worm) serotonin transporter b 0.0073 0.018 0.0574
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0102 0.0269 0.1813
Plasmodium falciparum peptidase, putative 0.0082 0.0209 0.7304
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0016 0.0006 0.0006
Schistosoma mansoni hypothetical protein 0.0096 0.025 0.0432
Trichomonas vaginalis D-aminoacylase, putative 0.0118 0.0319 0.2144
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0016 0.0006 0.0039
Schistosoma mansoni lamin 0.0026 0.0037 0.0064
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0105 0.0247
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.002 0.002
Loa Loa (eye worm) beta-lactamase 0.0118 0.0319 0.1014
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0071 0.0931
Loa Loa (eye worm) hypothetical protein 0.0082 0.0209 0.0664
Trichomonas vaginalis guanylate cyclase, putative 0.0017 0.0008 0.0055
Echinococcus granulosus Lysosomal Pro X carboxypeptidase 0.0102 0.0269 0.0466
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0067 0.0162 0.0381
Brugia malayi aryl hydrocarbon receptor nuclear translocator protein, putative 0.0044 0.0091 0.0288
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.002 0.0063
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0017 0.0009 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0102 0.0269 0.1813
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0004 0.0044
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0075 0.0186 0.2454
Loa Loa (eye worm) MH2 domain-containing protein 0.0034 0.0059 0.0188
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.002 0.0063
Loa Loa (eye worm) hypothetical protein 0.0016 0.0006 0.0018
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0015 0.0036
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0063
Echinococcus multilocularis lamin dm0 0.0026 0.0037 0.0037
Schistosoma mansoni intermediate filament proteins 0.0026 0.0037 0.0064
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0105 0.0335
Schistosoma mansoni inositol monophosphatase 0.0075 0.0186 0.0322
Schistosoma mansoni voltage-gated potassium channel 0.0049 0.0106 0.0183
Mycobacterium tuberculosis Probable esterase LipL 0.0118 0.0319 0.0747
Onchocerca volvulus 0.0145 0.0403 0.1281
Loa Loa (eye worm) MH2 domain-containing protein 0.0492 0.1467 0.4669
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0016 0.0006 0.0039
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0105 0.1385
Loa Loa (eye worm) G protein alpha subunit 3 0.0016 0.0006 0.0018
Brugia malayi mothers against decapentaplegic homolog 3 0.0015 0.0002 0.0007
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0061 0.0144
Echinococcus multilocularis inositol monophosphatase 1 0.0075 0.0186 0.0186
Mycobacterium leprae Probable transcriptional regulatory repressor protein (TetR-family) EthR 0.1403 0.4265 1
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0368 0.1087 0.188
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0042 0.0084 0.0566
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.002 0.0034
Echinococcus multilocularis tumor protein p63 0.0679 0.2041 0.2041
Entamoeba histolytica prolyl oligopeptidase family protein 0.0082 0.0209 0.2748
Giardia lamblia Alanyl dipeptidyl peptidase 0.0082 0.0209 0.7616
Schistosoma mansoni hypothetical protein 0.0206 0.059 0.1021
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0145 0.0403 0.1281
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0071 0.0476
Echinococcus granulosus lysosomal alpha glucosidase 0.0168 0.0472 0.0816
Loa Loa (eye worm) hypothetical protein 0.0073 0.018 0.0574
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0016 0.0006 0.001
Echinococcus multilocularis smad 0.0034 0.0059 0.0059
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.002 0.0063
Loa Loa (eye worm) hypothetical protein 0.0036 0.0068 0.0215
Loa Loa (eye worm) hypothetical protein 0.0118 0.0319 0.1014
Schistosoma mansoni tar DNA-binding protein 0.0202 0.0577 0.0998
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0017 0.0008 0.0055
Onchocerca volvulus 0.0016 0.0006 0.0018
Schistosoma mansoni GTP-binding protein (I) alpha subunit gnai 0.0016 0.0006 0.001
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0048 0.0105 0.0247
Mycobacterium ulcerans AcrR family transcriptional regulator 0.1403 0.4265 1
Echinococcus multilocularis survival motor neuron protein 1 0.0712 0.2144 0.2144
Mycobacterium ulcerans TetR family transcriptional regulator 0.1403 0.4265 1
Trichomonas vaginalis sucrase-isomaltase, putative 0.0037 0.0071 0.0476
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0063
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0004 0.0008
Echinococcus granulosus beta LACTamase domain containing family member 0.0118 0.0319 0.0551
Loa Loa (eye worm) hypothetical protein 0.0036 0.0068 0.0215
Loa Loa (eye worm) transcription factor SMAD2 0.0492 0.1467 0.4669
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0016 0.0006 0.001
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0096 0.025 0.0432
Schistosoma mansoni coup transcription factor 0.0021 0.002 0.0034
Schistosoma mansoni smad1 5 8 and 0.0034 0.0059 0.0102
Echinococcus multilocularis neuropeptide receptor A26 0.0466 0.1389 0.1389
Onchocerca volvulus 0.0097 0.0255 0.081
Echinococcus granulosus tar DNA binding protein 0.0202 0.0577 0.0998
Brugia malayi MH2 domain containing protein 0.0015 0.0002 0.0007
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0118 0.0319 0.0747
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0037 0.0118
Echinococcus granulosus smad 0.0034 0.0059 0.0102
Loa Loa (eye worm) RNA binding protein 0.0202 0.0577 0.1837
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0004 0.0014
Echinococcus granulosus acylamino acid releasing enzyme 0.0082 0.0209 0.0361
Loa Loa (eye worm) hypothetical protein 0.0266 0.0775 0.2466
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0349 0.1027 1
Plasmodium vivax SET domain protein, putative 0.0063 0.0149 0.4677
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0071 0.0688
Schistosoma mansoni voltage-gated potassium channel 0.0049 0.0106 0.0183
Schistosoma mansoni ap endonuclease 0.0019 0.0015 0.0026
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0017 0.0008 0.0079
Loa Loa (eye worm) hypothetical protein 0.0302 0.0884 0.2813
Loa Loa (eye worm) hypothetical protein 0.0368 0.1087 0.346
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0015 0.0049
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.002 0.002
Schistosoma mansoni cellular tumor antigen P53 0.0099 0.0261 0.0452
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0302 0.0884 0.2813
Loa Loa (eye worm) solute carrier family 6 member 4 0.0073 0.018 0.0574
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0082 0.0209 0.0489
Brugia malayi Serine protease Z688.6 precursor 0.0102 0.0269 0.0857
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0017 0.0008 0.0055
Loa Loa (eye worm) hypothetical protein 0.0102 0.0269 0.0857
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0105 0.0335
Brugia malayi hypothetical protein 0.0712 0.2144 0.6824
Onchocerca volvulus 0.0099 0.0261 0.0832
Loa Loa (eye worm) hypothetical protein 0.0206 0.059 0.1879
Schistosoma mansoni lysosomal Pro-Xaa carboxypeptidase (S28 family) 0.0102 0.0269 0.0466
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0004 0.0008
Schistosoma mansoni tar DNA-binding protein 0.0202 0.0577 0.0998
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.002 0.0034
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0082 0.0209 0.2032
Echinococcus granulosus mothers against decapentaplegic 2 0.0015 0.0002 0.0004
Echinococcus granulosus inositol monophosphatase 1 0.0075 0.0186 0.0322
Loa Loa (eye worm) hypothetical protein 0.0082 0.0209 0.0664
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0096 0.025 0.0432
Schistosoma mansoni lamin 0.0026 0.0037 0.0064
Echinococcus granulosus geminin 0.0165 0.0464 0.0803
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.002 0.0063
Trypanosoma cruzi hypothetical protein, conserved 0.0082 0.0209 0.2032
Echinococcus granulosus mothers against decapentaplegic 5 0.0034 0.0059 0.0102
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0016 0.0006 0.001
Echinococcus multilocularis GA binding protein alpha chain 0.0087 0.0225 0.0225
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0118 0.0319 0.0551
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0008 0.0055
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0105 0.1024
Plasmodium vivax hypothetical protein, conserved 0.0118 0.0319 1
Loa Loa (eye worm) hypothetical protein 0.0118 0.0319 0.1014
Toxoplasma gondii ABC1 family protein 0.0118 0.0319 0.3101
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0004 0.001
Treponema pallidum sodium- and chloride- dependent transporter 0.0073 0.018 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.0071 0.0225
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0016 0.0006 0.001
Toxoplasma gondii hypothetical protein 0.0082 0.0209 0.2032
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0016 0.0006 0.0018
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0036 0.0068 0.0158
Loa Loa (eye worm) hypothetical protein 0.0099 0.0261 0.0832
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.002 0.002
Mycobacterium ulcerans esterase/lipase LipP 0.0118 0.0319 0.0747
Trichomonas vaginalis D-aminoacylase, putative 0.0118 0.0319 0.2144
Onchocerca volvulus 0.0118 0.0319 0.1014
Onchocerca volvulus 0.0498 0.1486 0.4728
Echinococcus multilocularis GPCR, family 2 0.0096 0.025 0.025
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.002 0.0063
Brugia malayi Calcitonin receptor-like protein seb-1 0.0302 0.0884 0.2813
Trypanosoma cruzi hypothetical protein, conserved 0.0118 0.0319 0.3101
Schistosoma mansoni hypothetical protein 0.0145 0.0403 0.0696
Echinococcus multilocularis beta LACTamase domain containing family member 0.0118 0.0319 0.0319
Schistosoma mansoni single-minded 0.0017 0.0008 0.0014
Brugia malayi prolyl oligopeptidase family protein 0.0082 0.0209 0.0664
Mycobacterium tuberculosis Probable lipase LipE 0.0118 0.0319 0.0747
Trichomonas vaginalis penicillin-binding protein, putative 0.0118 0.0319 0.2144
Schistosoma mansoni hypothetical protein 0.0165 0.0464 0.0803
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.002 0.002
Brugia malayi hypothetical protein 0.0159 0.0446 0.142
Echinococcus granulosus Smad4 0.0034 0.0059 0.0102
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0102 0.0269 0.1813
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0102 0.0269 0.1813
Loa Loa (eye worm) hypothetical protein 0.0039 0.0075 0.0239
Loa Loa (eye worm) hypothetical protein 0.0036 0.0068 0.0215
Trichomonas vaginalis D-aminoacylase, putative 0.0118 0.0319 0.2144
Echinococcus granulosus Lysosomal Pro X carboxypeptidase 0.1897 0.5782 1
Echinococcus multilocularis tar DNA binding protein 0.0202 0.0577 0.0577
Plasmodium falciparum ataxin-2 like protein, putative 0.0107 0.0286 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0168 0.0472 0.0472
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.1037 0.3142 0.5434
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.1037 0.3142 0.3142
Brugia malayi hypothetical protein 0.0039 0.0077 0.0246
Toxoplasma gondii exonuclease III APE 0.0019 0.0015 0.0149
Echinococcus multilocularis mothers against decapentaplegic 6 0.0015 0.0002 0.0002
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0016 0.0006 0.0006
Plasmodium vivax ataxin-2 like protein, putative 0.0107 0.0286 0.8972
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0071 0.0931
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.002 0.0034
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0063
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0102 0.0269 0.1813
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0075 0.0186 0.1255
Brugia malayi RNA binding protein 0.0202 0.0577 0.1837
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.002 0.0063
Giardia lamblia Thymus-specific serine protease precursor 0.0102 0.0269 1
Schistosoma mansoni transcription factor LCR-F1 0.0262 0.076 0.1314
Loa Loa (eye worm) hypothetical protein 0.0016 0.0006 0.0018
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0375 0.1109 0.1919
Brugia malayi MH2 domain containing protein 0.0034 0.0059 0.0188
Echinococcus granulosus neuropeptide s receptor 0.0466 0.1389 0.2402
Trypanosoma cruzi PAB1-binding protein , putative 0.0107 0.0286 0.2782
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0082 0.0209 0.0489
Loa Loa (eye worm) hypothetical protein 0.0063 0.0149 0.0474
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0017 0.0008 0.0055
Mycobacterium tuberculosis Probable lipase LipD 0.0118 0.0319 0.0747
Echinococcus granulosus histone lysine methyltransferase setb 0.0063 0.0149 0.0258
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.002 0.0063
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0754 0.2271 0.5324
Trypanosoma cruzi PAB1-binding protein , putative 0.0107 0.0286 0.2782
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0048 0.0105 0.0247
Echinococcus granulosus biogenic amine 5HT receptor 0.0158 0.0442 0.0764
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0045 0.0093 0.0296
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0063 0.0149 0.0258
Brugia malayi Smad1 0.0034 0.0059 0.0188
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0075 0.0186 0.1815
Brugia malayi Pre-SET motif family protein 0.0063 0.0149 0.0474
Onchocerca volvulus 0.0118 0.0319 0.1014
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.1037 0.3142 1
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0102 0.0269 0.1813
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0004 0.0004
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0075 0.0186 0.1815
Entamoeba histolytica prolyl oligopeptidase family protein 0.0082 0.0209 0.2748
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0016 0.0006 0.001
Echinococcus multilocularis serotonin receptor 0.0158 0.0442 0.0442
Loa Loa (eye worm) hypothetical protein 0.0323 0.095 0.3023
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.002 0.0063
Echinococcus multilocularis musashi 0.0026 0.0037 0.0037
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0036 0.0068 0.0158
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0118 0.0319 0.0551
Echinococcus granulosus aryl hydrocarbon receptor 0.0057 0.013 0.0225
Trypanosoma cruzi serine carboxypeptidase S28, putative 0.0102 0.0269 0.2622
Trichomonas vaginalis lysosomal pro-X carboxypeptidase, putative 0.0102 0.0269 0.1813
Trichomonas vaginalis guanylate cyclase, putative 0.0017 0.0008 0.0055
Echinococcus multilocularis Lysosomal Pro X carboxypeptidase 0.1897 0.5782 0.5782
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0096 0.025 0.025
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0045 0.0093 0.0296
Mycobacterium leprae conserved hypothetical protein 0.0118 0.0319 0.0747
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0073 0.018 0.0574
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0004 0.0014
Loa Loa (eye worm) norepinephrine transporter 0.0073 0.018 0.0574
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0017 0.0008 0.0079
Echinococcus multilocularis Smad4 0.0034 0.0059 0.0059
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0017 0.0009 0.0016
Trypanosoma brucei PAB1-binding protein , putative 0.0107 0.0286 0.2782
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0037 0.0118
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0063
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0082 0.0209 0.2032
Trichomonas vaginalis penicillin-binding protein, putative 0.0118 0.0319 0.2144
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0375 0.1109 0.3531
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0105 0.0247
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0105 0.1385
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0017 0.0008 0.0079
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.002 0.0034
Echinococcus multilocularis mothers against decapentaplegic 5 0.0034 0.0059 0.0059
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.002 0.0034
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.002 0.0063
Loa Loa (eye worm) hypothetical protein 0.0118 0.0319 0.1014
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.002 0.0063
Schistosoma mansoni family S28 unassigned peptidase (S28 family) 0.1897 0.5782 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.002 0.002
Echinococcus multilocularis aryl hydrocarbon receptor 0.0057 0.013 0.013
Loa Loa (eye worm) hypothetical protein 0.0039 0.0077 0.0246
Trichomonas vaginalis GTP-binding protein (O) alpha subunit, gnao, putative 0.0016 0.0006 0.0039
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0087 0.0225 0.0716
Giardia lamblia Serine peptidase, putative 0.0102 0.0269 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0375 0.1109 0.3531
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0375 0.1109 0.1109
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0063
Schistosoma mansoni GTP-binding protein alpha subunit 0.0016 0.0006 0.001
Schistosoma mansoni Smad4 0.0015 0.0002 0.0004
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.002 0.0063
Loa Loa (eye worm) MH1 domain-containing protein 0.0015 0.0002 0.0007
Entamoeba histolytica serine carboxypeptidase (S28) family protein 0.0102 0.0269 0.3545
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0016 0.0006 0.001
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0004 0.0141
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.1037 0.3142 0.5434
Brugia malayi Glycosyl hydrolases family 31 protein 0.0168 0.0472 0.1502
Leishmania major protein kinase, putative 0.0017 0.0008 0.0079
Brugia malayi G-protein alpha subunit 0.0016 0.0006 0.0018
Loa Loa (eye worm) hypothetical protein 0.0039 0.0077 0.0246
Trypanosoma cruzi hypothetical protein, conserved 0.0118 0.0319 0.3101
Onchocerca volvulus 0.0021 0.002 0.0063
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0004 0.0044
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0015 0.0015
Brugia malayi MH1 domain containing protein 0.0019 0.0013 0.0042
Mycobacterium tuberculosis Probable peptidase 0.0082 0.0209 0.0489
Trypanosoma brucei oligopeptidase b 0.0082 0.0209 0.2032
Brugia malayi hypothetical protein 0.0016 0.0006 0.0018
Onchocerca volvulus 0.0026 0.0037 0.0118
Schistosoma mansoni hypothetical protein 0.0165 0.0464 0.0803
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.002 0.0063
Mycobacterium ulcerans beta-lactamase 0.0118 0.0319 0.0747
Schistosoma mansoni sodium/chloride dependent transporter 0.0073 0.018 0.0312
Echinococcus granulosus mothers against decapentaplegic 6 0.0015 0.0002 0.0004
Echinococcus granulosus lamin 0.0026 0.0037 0.0064
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0082 0.0209 0.2032
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0105 0.1024
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.0016 0.0006 0.0018
Loa Loa (eye worm) hypothetical protein 0.0107 0.0286 0.091
Trichomonas vaginalis inositol monophosphatase, putative 0.0075 0.0186 0.1255
Echinococcus granulosus lamin dm0 0.0026 0.0037 0.0064
Loa Loa (eye worm) hypothetical protein 0.0096 0.025 0.0795
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0168 0.0472 0.1502
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0057 0.013 0.0414
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0082 0.0209 0.2032
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0063 0.0149 0.145
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0349 0.1027 1
Entamoeba histolytica serine carboxypeptidase (S28) family protein 0.0102 0.0269 0.3545
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0016 0.0006 0.001
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0004 0.0157
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0017 0.0008 0.0055
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0042
Brugia malayi MH1 domain containing protein 0.0019 0.0013 0.0042
Schistosoma mansoni smad1 5 8 and 0.0034 0.0059 0.0102
Onchocerca volvulus 0.0026 0.0037 0.0118
Loa Loa (eye worm) hypothetical protein 0.0158 0.0442 0.1406
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0045 0.0093 0.0161
Brugia malayi prolyl oligopeptidase family protein 0.0349 0.1027 0.327
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0061 0.0144
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0075 0.0186 0.1255
Onchocerca volvulus 0.0073 0.018 0.0574
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0349 0.1027 1
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0015 0.0002 0.0007
Onchocerca volvulus 0.0016 0.0006 0.0018
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0063 0.0149 0.0149
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0063 0.0149 0.0149
Leishmania major hypothetical protein, conserved 0.0118 0.0319 0.3101
Leishmania major hypothetical protein, conserved 0.0107 0.0286 0.2782
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.002 0.0063
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0016 0.0006 0.0039
Toxoplasma gondii LsmAD domain-containing protein 0.0107 0.0286 0.2782
Schistosoma mansoni Smad4 0.0015 0.0002 0.0004
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0102 0.0269 0.1813
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0015 0.048
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.002 0.0063
Loa Loa (eye worm) latrophilin receptor protein 2 0.0096 0.025 0.0795
Brugia malayi prolyl oligopeptidase family protein 0.1037 0.3142 1
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.0016 0.0006 0.0006
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0015 0.0149
Mycobacterium tuberculosis Conserved protein 0.0118 0.0319 0.0747
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0016 0.0006 0.0018
Loa Loa (eye worm) hypothetical protein 0.0017 0.0008 0.0026
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0102 0.0269 0.1813
Schistosoma mansoni Smad4 0.0034 0.0059 0.0102
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.002 0.0034
Entamoeba histolytica hypothetical protein 0.0262 0.076 1
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0034 0.0059 0.0102
Loa Loa (eye worm) hypothetical protein 0.0102 0.0269 0.0857
Brugia malayi hypothetical protein 0.0107 0.0286 0.091
Schistosoma mansoni tar DNA-binding protein 0.0202 0.0577 0.0998
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.002 0.0063
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0037 0.0071 0.0688
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0017 0.0008 0.0079
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0375 0.1109 0.1109
Loa Loa (eye worm) hypothetical protein 0.0036 0.0068 0.0215
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0082 0.0209 0.2748
Onchocerca volvulus Protein cycle homolog 0.004 0.0078 0.0248
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.0071 0.0122
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0149 0.0258
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.002 0.0063
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0102 0.0269 0.1813
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0004 0.0004
Brugia malayi steroid hormone receptor 0.0021 0.002 0.0063
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.002 0.0063
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0149 0.0258
Trypanosoma cruzi oligopeptidase b 0.0082 0.0209 0.2032
Schistosoma mansoni smad1 5 8 and 0.0034 0.0059 0.0102
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0096 0.025 0.025
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0118 0.0319 0.0747
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0016 0.0006 0.001
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0149 0.0258
Schistosoma mansoni trimeric G-protein alpha o subunit 0.0016 0.0006 0.001
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.0105 0.0247
Trypanosoma brucei prolyl endopeptidase 0.0082 0.0209 0.2032
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0082 0.0209 0.2748
Loa Loa (eye worm) hypothetical protein 0.0048 0.0105 0.0335
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0375 0.1109 0.1919
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.0016 0.0006 0.0018
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.002 0.0063
Entamoeba histolytica hypothetical protein, conserved 0.0082 0.0209 0.2748
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.002 0.0034
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0063
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.002 0.0063
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0042 0.0084 0.0566
Onchocerca volvulus 0.0016 0.0006 0.0018
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0071 0.0476
Trichomonas vaginalis conserved hypothetical protein 0.0102 0.0269 0.1813
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0015 0.0149
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0016 0.0006 0.001
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0349 0.1027 0.1777
Loa Loa (eye worm) hypothetical protein 0.0102 0.0269 0.0857
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0118 0.0319 0.0747
Brugia malayi Serine carboxypeptidase S28 family protein 0.0102 0.0269 0.0857
Brugia malayi MH2 domain containing protein 0.0034 0.0059 0.0188
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0096 0.025 0.0795
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0063
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0004 0.0044
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0375 0.1109 0.1919
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.002 0.002
Mycobacterium tuberculosis Conserved protein 0.0118 0.0319 0.0747
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.006 0.0142 0.0245
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.002 0.002
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0082 0.0209 0.0361
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0375 0.1109 0.1919
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.002 0.0063
Loa Loa (eye worm) hypothetical protein 0.0118 0.0319 0.1014
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0071 0.0476
Loa Loa (eye worm) Smad1 0.0034 0.0059 0.0188
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0349 0.1027 1
Loa Loa (eye worm) hypothetical protein 0.0102 0.0269 0.0857
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0202 0.0577 0.1837
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0016 0.0006 0.0039
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0067 0.0162 0.0381
Brugia malayi Serine protease Z688.6 precursor 0.0102 0.0269 0.0857
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0102 0.0269 0.1813
Leishmania major oligopeptidase b 0.0082 0.0209 0.2032
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0082 0.0209 0.0361
Schistosoma mansoni alpha-glucosidase 0.0145 0.04 0.0692
Loa Loa (eye worm) TAR-binding protein 0.0202 0.0577 0.1837
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0004 0.0004
Onchocerca volvulus 0.0118 0.0319 0.1014
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0073 0.018 0.0312
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0048 0.0105 0.0247
Brugia malayi Ets-domain containing protein 0.0087 0.0225 0.0716
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.0016 0.0006 0.0018
Onchocerca volvulus 0.0048 0.0105 0.0335
Schistosoma mansoni smad 0.0034 0.0059 0.0102
Onchocerca volvulus 0.0063 0.0149 0.0474
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0061 0.0144
Brugia malayi nuclear hormone receptor 0.0021 0.002 0.0063
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0118 0.0319 0.1014
Loa Loa (eye worm) hypothetical protein 0.0016 0.0006 0.0018
Brugia malayi MH1 domain containing protein 0.0034 0.0059 0.0188
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.002 0.0034
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0302 0.0884 0.2813
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.0016 0.0006 0.0018
Entamoeba histolytica hypothetical protein 0.0262 0.076 1
Loa Loa (eye worm) fli-1 protein 0.0265 0.0772 0.2456
Brugia malayi Ets-domain containing protein 0.0087 0.0225 0.0716
Entamoeba histolytica hypothetical protein 0.0262 0.076 1
Schistosoma mansoni aryl hydrocarbon receptor nuclear translocator homolog (darnt) 0.004 0.0078 0.0135
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0004 0.0004
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0071 0.0688
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0016 0.0006 0.001
Loa Loa (eye worm) MH2 domain-containing protein 0.0015 0.0002 0.0007
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.002 0.002
Onchocerca volvulus Prolyl endopeptidase homolog 0.0082 0.0209 0.0664
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0102 0.0269 0.1813
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.002 0.002
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0015 0.0049
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0017 0.0008 0.0055
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0048 0.0105 0.0247
Echinococcus multilocularis expressed protein 0.0016 0.0006 0.0006
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0004 0.0044
Schistosoma mansoni thyroid hormone receptor 0.0021 0.002 0.0034
Loa Loa (eye worm) hypothetical protein 0.0016 0.0006 0.0018
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.0071 0.0071
Entamoeba histolytica G protein alpha subunit, putative 0.0016 0.0006 0.0076
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.002 0.0034
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0034 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0015 0.0002 0.0007
Brugia malayi intermediate filament protein 0.0026 0.0037 0.0118
Brugia malayi beta-lactamase 0.0118 0.0319 0.1014
Mycobacterium tuberculosis Probable hydrolase 0.0118 0.0319 0.0747
Echinococcus multilocularis lamin 0.0026 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0712 0.2144 0.6824
Schistosoma mansoni survival motor neuron protein 0.0145 0.0403 0.0696
Loa Loa (eye worm) hypothetical protein 0.0026 0.0036 0.0113
Loa Loa (eye worm) hypothetical protein 0.0036 0.0068 0.0215
Trichomonas vaginalis prolylcarboxypeptidase, putative 0.0102 0.0269 0.1813
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.004 0.0078 0.0248
Echinococcus multilocularis mothers against decapentaplegic 2 0.0015 0.0002 0.0002
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0017 0.0008 0.0079
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.0016 0.0006 0.0018
Echinococcus multilocularis prolyl endopeptidase 0.0082 0.0209 0.0209
Entamoeba histolytica hypothetical protein 0.0262 0.076 1
Schistosoma mansoni hypothetical protein 0.0048 0.0104 0.018
Trichomonas vaginalis maltase-glucoamylase, putative 0.0037 0.0071 0.0476
Loa Loa (eye worm) MH1 domain-containing protein 0.0034 0.0059 0.0188
Echinococcus granulosus GPCR family 2 0.0096 0.025 0.0432
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0082 0.0209 0.0489
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.002 0.0063
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0037 0.0118
Brugia malayi beta-lactamase family protein 0.0118 0.0319 0.1014
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.002 0.0034
Trypanosoma cruzi oligopeptidase b 0.0082 0.0209 0.2032
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0016 0.0006 0.001
Brugia malayi Pre-SET motif family protein 0.0437 0.13 0.4137
Schistosoma mansoni tar DNA-binding protein 0.0202 0.0577 0.0998
Brugia malayi hypothetical protein 0.0069 0.0169 0.0538
Loa Loa (eye worm) hypothetical protein 0.0075 0.0186 0.0592
Brugia malayi Fli-1 protein 0.0265 0.0772 0.2456
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.0016 0.0006 0.0018
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0015 0.0535
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0375 0.1109 0.1919
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0349 0.1027 0.1027
Mycobacterium ulcerans hypothetical protein 0.0048 0.0105 0.0247
Onchocerca volvulus 0.0056 0.0129 0.0411
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.002 0.0063
Schistosoma mansoni alpha-glucosidase 0.0145 0.04 0.0692

Activities

Activity type Activity value Assay description Source Reference
EC50 (binding) = 6.4 Agonist activity at human 5-HT1B receptor expressed in CHO cells assessed as stimulation of GTPgammaS binding by scintillation proximity assay ChEMBL. 20951584
Intrinsic activity (binding) = 0 Intrinsic activity at human 5-HT1A receptor expressed in HEK293 cells assessed as effect on GTPgammaS binding by scintillation proximity assay relative to 5HT ChEMBL. 20951584
Intrinsic activity (binding) = 0 Intrinsic activity at human 5-HT1D receptor expressed in CHO cells assessed as effect on GTPgammaS binding by scintillation proximity assay relative to 5HT ChEMBL. 20951584
Intrinsic activity (binding) = 0.4 Intrinsic activity at human 5-HT1B receptor expressed in CHO cells assessed as effect on GTPgammaS binding by scintillation proximity assay relative to 5HT ChEMBL. 20951584
Ki (binding) = 6.1 Displacement of [3H]-dofetilide in human ERG expressed in CHO cells by proximity assay ChEMBL. 20951584
Ki (binding) = 7.6 Displacement of [3H]-citalopram in human SERT expressed in LLCPK cells by filtration assay ChEMBL. 20951584
Ki (functional) = 9 Antagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assay ChEMBL. 20951584
Ki (functional) = 9.2 Antagonist activity at human 5-HT1A receptor expressed in HEK293 cells assessed as inhibition of GTPgammaS binding by scintillation proximity assay ChEMBL. 20951584

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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