Detailed information for compound 1261074

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 428.569 | Formula: C27H32N4O
  • H donors: 0 H acceptors: 2 LogP: 4.17 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1CCc2c(N1C)ccc(c2CCN1CCN(CC1)c1cccc2c1ccc(n2)C)C
  • InChi: 1S/C27H32N4O/c1-19-7-11-25-22(10-12-27(32)29(25)3)21(19)13-14-30-15-17-31(18-16-30)26-6-4-5-24-23(26)9-8-20(2)28-24/h4-9,11H,10,12-18H2,1-3H3
  • InChiKey: PDLXDQOODGXTSQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens potassium voltage-gated channel, subfamily H (eag-related), member 2 References
Homo sapiens solute carrier family 6 (neurotransmitter transporter), member 4 Starlite/ChEMBL References
Homo sapiens 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled Starlite/ChEMBL References
Homo sapiens 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled Starlite/ChEMBL References
Homo sapiens 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled Starlite/ChEMBL References
Homo sapiens v-ets avian erythroblastosis virus E26 oncogene homolog Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus biogenic amine 5HT receptor Get druggable targets OG5_133249 All targets in OG5_133249
Brugia malayi Fli-1 protein Get druggable targets OG5_131947 All targets in OG5_131947
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma mansoni ets-related Get druggable targets OG5_131947 All targets in OG5_131947
Schistosoma mansoni norepinephrine/norepinephrine transporter Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum expressed protein Get druggable targets OG5_133249 All targets in OG5_133249
Brugia malayi Sodium:neurotransmitter symporter family protein Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
Echinococcus granulosus serotonin transporter Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum ko:K04153 5-hydroxytryptamine (serotonin) receptor 1A, putative Get druggable targets OG5_133249 All targets in OG5_133249
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog Get druggable targets OG5_128858 All targets in OG5_128858
Schistosoma mansoni biogenic amine (5HT) receptor Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma japonicum ko:K05336 solute carrier family 6 (neurotransmitter transporter), invertebrate, putative Get druggable targets OG5_128364 All targets in OG5_128364
Echinococcus multilocularis serotonin transporter Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133680 All targets in OG5_133680
Trichomonas vaginalis voltage and ligand gated potassium channel, putative Get druggable targets OG5_128858 All targets in OG5_128858
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133249 All targets in OG5_133249
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum 5-hydroxytryptamine receptor, putative Get druggable targets OG5_133680 All targets in OG5_133680
Brugia malayi Serotonin/octopamine receptor family protein 7 Get druggable targets OG5_141128 All targets in OG5_141128
Treponema pallidum sodium- and chloride- dependent transporter Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) solute carrier family 6 member 4 Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum IPR000175,Sodium:neurotransmitter symporter,domain-containing Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma mansoni voltage-gated potassium channel Get druggable targets OG5_128858 All targets in OG5_128858
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) fli-1 protein Get druggable targets OG5_131947 All targets in OG5_131947
Echinococcus granulosus potassium voltage gated channel subfamily H Get druggable targets OG5_128858 All targets in OG5_128858
Onchocerca volvulus Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Potassium voltage-gated channel subfamily H member 2, putative Get druggable targets OG5_128858 All targets in OG5_128858
Loa Loa (eye worm) voltage and ligand gated potassium channel Get druggable targets OG5_128858 All targets in OG5_128858
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma mansoni voltage-gated potassium channel Get druggable targets OG5_128858 All targets in OG5_128858
Schistosoma japonicum ko:K09435 transcriptional regulator ERG, putative Get druggable targets OG5_131947 All targets in OG5_131947
Echinococcus multilocularis serotonin receptor Get druggable targets OG5_133249 All targets in OG5_133249
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128858 All targets in OG5_128858
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_141128 All targets in OG5_141128
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Trichomonas vaginalis voltage and ligand gated potassium channel, putative Get druggable targets OG5_128858 All targets in OG5_128858
Schistosoma mansoni sodium/chloride dependent transporter Get druggable targets OG5_128364 All targets in OG5_128364
Echinococcus multilocularis serotonin receptor Get druggable targets OG5_133249 All targets in OG5_133249
Loa Loa (eye worm) serotonin transporter b Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133249 All targets in OG5_133249
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_141128 All targets in OG5_141128
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor Get druggable targets OG5_141128 All targets in OG5_141128
Schistosoma japonicum Sodium-dependent noradrenaline transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) norepinephrine transporter Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum ko:K04910 potassium voltage-gated channel, Eag-related subfamily H, member 7, putative Get druggable targets OG5_128858 All targets in OG5_128858
Schistosoma japonicum ko:K04910 potassium voltage-gated channel, Eag-related subfamily H, member 7, putative Get druggable targets OG5_128858 All targets in OG5_128858
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Echinococcus multilocularis potassium voltage gated channel subfamily H Get druggable targets OG5_128858 All targets in OG5_128858
Schistosoma japonicum Octopamine receptor, putative Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma japonicum ko:K04165 Oamb gene product from transcript, putative Get druggable targets OG5_141128 All targets in OG5_141128
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Sodium:neurotransmitter symporter family protein solute carrier family 6 (neurotransmitter transporter), member 4 630 aa 574 aa 31.5 %
Brugia malayi AT19640p 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled 390 aa 335 aa 21.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.002 0.0063
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.002 0.0063
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0082 0.0209 0.1405
Mycobacterium ulcerans TetR family transcriptional regulator 0.1403 0.4265 1
Schistosoma mansoni tar DNA-binding protein 0.0202 0.0577 0.0998
Brugia malayi MH2 domain containing protein 0.0034 0.0059 0.0188
Echinococcus granulosus Smad4 0.0034 0.0059 0.0102
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0017 0.0008 0.0055
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0045 0.0093 0.0093
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.0071 0.0071
Brugia malayi Ets-domain containing protein 0.0087 0.0225 0.0716
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0016 0.0006 0.0039
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.1037 0.3142 0.5434
Echinococcus multilocularis beta LACTamase domain containing family member 0.0118 0.0319 0.0319
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0016 0.0006 0.0006
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.002 0.002
Loa Loa (eye worm) nuclear factor I 0.0019 0.0013 0.0042
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.002 0.0034
Loa Loa (eye worm) hypothetical protein 0.0323 0.095 0.3023
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0118 0.0319 0.0747
Brugia malayi hypothetical protein 0.0266 0.0775 0.2466
Trichomonas vaginalis adenylate cyclase, putative 0.0017 0.0008 0.0055
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.002 0.0034
Trypanosoma brucei PAB1-binding protein , putative 0.0107 0.0286 0.2782
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0034 0.0059 0.0059
Leishmania major hypothetical protein, conserved 0.0107 0.0286 0.2782
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.004 0.0078 0.0248
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.002 0.0063
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.002 0.0034
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0016 0.0006 0.0039
Trichomonas vaginalis sucrase-isomaltase, putative 0.0037 0.0071 0.0476
Loa Loa (eye worm) hypothetical protein 0.0048 0.0105 0.0335
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.002 0.0034
Echinococcus multilocularis serotonin transporter 0.0073 0.018 0.018
Mycobacterium tuberculosis Probable lipase LipD 0.0118 0.0319 0.0747
Onchocerca volvulus 0.0498 0.1486 0.4728
Schistosoma mansoni tar DNA-binding protein 0.0202 0.0577 0.0998
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0075 0.0186 0.2454
Schistosoma mansoni transcription factor LCR-F1 0.0262 0.076 0.1314
Brugia malayi latrophilin 2 splice variant baaae 0.0206 0.059 0.1879
Schistosoma mansoni hypothetical protein 0.0048 0.0104 0.018
Echinococcus multilocularis prolyl endopeptidase 0.0082 0.0209 0.0209
Schistosoma mansoni voltage-gated potassium channel 0.0049 0.0106 0.0183
Loa Loa (eye worm) prolyl oligopeptidase 0.1037 0.3142 1
Brugia malayi MH1 domain containing protein 0.0034 0.0059 0.0188
Brugia malayi Serine protease Z688.6 precursor 0.0102 0.0269 0.0857
Loa Loa (eye worm) RNA binding protein 0.0202 0.0577 0.1837
Trypanosoma brucei hypothetical protein, conserved 0.0118 0.0319 0.3101
Brugia malayi mothers against decapentaplegic homolog 3 0.0015 0.0002 0.0007
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0075 0.0186 0.1815
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0082 0.0209 0.2748
Mycobacterium ulcerans esterase/lipase LipP 0.0118 0.0319 0.0747
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0067 0.0162 0.0381
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0105 0.0247
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0102 0.0269 0.1813
Loa Loa (eye worm) hypothetical protein 0.0118 0.0319 0.1014
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0368 0.1087 0.188
Schistosoma mansoni tar DNA-binding protein 0.0202 0.0577 0.0998
Echinococcus multilocularis GA binding protein alpha chain 0.0087 0.0225 0.0225
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.0016 0.0006 0.0018
Echinococcus granulosus GA binding protein alpha chain 0.0087 0.0225 0.0389
Trichomonas vaginalis conserved hypothetical protein 0.0102 0.0269 0.1813
Loa Loa (eye worm) hypothetical protein 0.0075 0.0186 0.0592
Trypanosoma cruzi hypothetical protein, conserved 0.0118 0.0319 0.3101
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0015 0.0149
Trypanosoma cruzi putative prolyl carboxypeptidase, putative 0.0102 0.0269 0.2622
Trichomonas vaginalis conserved hypothetical protein 0.0082 0.0209 0.1405
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0016 0.0006 0.0018
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0017 0.0008 0.0079
Loa Loa (eye worm) hypothetical protein 0.0158 0.0442 0.1406
Trypanosoma cruzi PAB1-binding protein , putative 0.0107 0.0286 0.2782
Echinococcus multilocularis tar DNA binding protein 0.0202 0.0577 0.0577
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0073 0.018 0.0312
Schistosoma mansoni trimeric G-protein alpha o subunit 0.0016 0.0006 0.001
Mycobacterium leprae Probable lipase LipE 0.0118 0.0319 0.0747
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0067 0.0162 0.0381
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0145 0.0403 0.1281
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.002 0.0034
Schistosoma mansoni thyroid hormone receptor 0.0021 0.002 0.0034
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0063
Loa Loa (eye worm) hypothetical protein 0.0102 0.0269 0.0857
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0712 0.2144 0.6824
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0016 0.0006 0.001
Trypanosoma brucei glucosidase, putative 0.0037 0.0071 0.0688
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.002 0.0063
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0063
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.0016 0.0006 0.0018
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0016 0.0006 0.001
Leishmania major hypothetical protein, conserved 0.0118 0.0319 0.3101
Echinococcus granulosus neuropeptide receptor A26 0.0466 0.1389 0.2402
Brugia malayi hypothetical protein 0.0262 0.076 0.2418
Trypanosoma cruzi oligopeptidase b 0.0082 0.0209 0.2032
Trypanosoma cruzi hypothetical protein, conserved 0.0082 0.0209 0.2032
Loa Loa (eye worm) hypothetical protein 0.0016 0.0006 0.0018
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0016 0.0006 0.001
Brugia malayi MH2 domain containing protein 0.0034 0.0059 0.0188
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0017 0.0008 0.0079
Schistosoma mansoni nuclear hormone receptor 0.0021 0.002 0.0034
Echinococcus granulosus neuropeptide s receptor 0.0466 0.1389 0.2402
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0008 0.0055
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0082 0.0209 0.0489
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0105 0.0247
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0349 0.1027 1
Schistosoma mansoni tar DNA-binding protein 0.0202 0.0577 0.0998
Loa Loa (eye worm) hypothetical protein 0.0036 0.0068 0.0215
Schistosoma mansoni lamin 0.0026 0.0037 0.0064
Onchocerca volvulus 0.0118 0.0319 0.1014
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0045 0.0093 0.0296
Echinococcus multilocularis Lysosomal Pro X carboxypeptidase 0.0102 0.0269 0.0269
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0149 0.0258
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.002 0.0063
Trichomonas vaginalis conserved hypothetical protein 0.0102 0.0269 0.1813
Mycobacterium tuberculosis Conserved protein 0.0118 0.0319 0.0747
Schistosoma mansoni hypothetical protein 0.0096 0.025 0.0432
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0016 0.0006 0.0039
Mycobacterium ulcerans AcrR family transcriptional regulator 0.1403 0.4265 1
Brugia malayi PAS domain containing protein 0.0017 0.0008 0.0026
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.002 0.002
Brugia malayi Smad1 0.0034 0.0059 0.0188
Echinococcus granulosus GPCR family 2 0.0096 0.025 0.0432
Mycobacterium leprae Probable transcriptional regulatory repressor protein (TetR-family) EthR 0.1403 0.4265 1
Trichomonas vaginalis D-aminoacylase, putative 0.0118 0.0319 0.2144
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0048 0.0105 0.0247
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0063 0.0149 0.0149
Trichomonas vaginalis esterase, putative 0.0118 0.0319 0.2144
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0302 0.0884 0.2813
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.0016 0.0006 0.0018
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0034 0.0059 0.0102
Echinococcus multilocularis expressed protein 0.0016 0.0006 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.002 0.0063
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0375 0.1109 0.3531
Loa Loa (eye worm) Smad1 0.0034 0.0059 0.0188
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0016 0.0006 0.001
Loa Loa (eye worm) hypothetical protein 0.0036 0.0068 0.0215
Loa Loa (eye worm) hypothetical protein 0.0016 0.0006 0.0018
Schistosoma mansoni hypothetical protein 0.0145 0.0403 0.0696
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0082 0.0209 0.2032
Trichomonas vaginalis set domain proteins, putative 0.0498 0.1486 1
Schistosoma mansoni hypothetical protein 0.0262 0.076 0.1314
Onchocerca volvulus 0.0026 0.0037 0.0118
Loa Loa (eye worm) transcription factor SMAD2 0.0492 0.1467 0.4669
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0102 0.0269 0.1813
Mycobacterium leprae Possible regulatory protein 0.0017 0.0008 0.0019
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0015 0.0002 0.0007
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0105 0.0247
Brugia malayi ecdysteroid receptor 0.0021 0.002 0.0063
Brugia malayi Calcitonin receptor-like protein seb-1 0.0302 0.0884 0.2813
Brugia malayi hypothetical protein 0.004 0.0078 0.0248
Brugia malayi hypothetical protein 0.0159 0.0446 0.142
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0075 0.0186 0.0437
Loa Loa (eye worm) norepinephrine transporter 0.0073 0.018 0.0574
Echinococcus granulosus TGF beta signal transducer SmadC 0.0034 0.0059 0.0102
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.002 0.0034
Schistosoma mansoni single-minded 0.0017 0.0008 0.0014
Entamoeba histolytica acyl-coA synthetase, putative 0.0048 0.0105 0.1385
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0016 0.0006 0.0006
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0105 0.1385
Plasmodium vivax hypothetical protein, conserved 0.0082 0.0209 0.6553
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.002 0.0034
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0096 0.025 0.025
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.002 0.0063
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0017 0.0008 0.0079
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0102 0.0269 0.1813
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0015 0.0149
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0015 0.0149
Brugia malayi isocitrate dehydrogenase 0.0016 0.0004 0.0014
Schistosoma mansoni thyroid hormone receptor 0.0021 0.002 0.0034
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0015 0.0036
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.002 0.0063
Onchocerca volvulus Protein cycle homolog 0.004 0.0078 0.0248
Loa Loa (eye worm) hypothetical protein 0.0082 0.0209 0.0664
Loa Loa (eye worm) prolyl oligopeptidase 0.0082 0.0209 0.0664
Loa Loa (eye worm) hypothetical protein 0.0056 0.0129 0.0411
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0004 0.0004
Mycobacterium ulcerans hypothetical protein 0.0048 0.0105 0.0247
Brugia malayi hypothetical protein 0.0039 0.0077 0.0246
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0017 0.0008 0.0079
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0042 0.0084 0.0566
Loa Loa (eye worm) hypothetical protein 0.0368 0.1087 0.346
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0015 0.0049
Plasmodium vivax SET domain protein, putative 0.0063 0.0149 0.4677
Loa Loa (eye worm) hypothetical protein 0.0036 0.0068 0.0215
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0437 0.13 0.4137
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0063
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.002 0.002
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0004 0.0008
Loa Loa (eye worm) latrophilin receptor protein 2 0.0096 0.025 0.0795
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0118 0.0319 0.0551
Schistosoma mansoni alpha-glucosidase 0.0145 0.04 0.0692
Brugia malayi Glycosyl hydrolases family 31 protein 0.0168 0.0472 0.1502
Loa Loa (eye worm) TAR-binding protein 0.0202 0.0577 0.1837
Trichomonas vaginalis maltase-glucoamylase, putative 0.0037 0.0071 0.0476
Loa Loa (eye worm) fli-1 protein 0.0265 0.0772 0.2456
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.002 0.0063
Brugia malayi hypothetical protein 0.0016 0.0006 0.0018
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0004 0.0004
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0045 0.0093 0.0161
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.0016 0.0006 0.0018
Loa Loa (eye worm) hypothetical protein 0.0039 0.0077 0.0246
Echinococcus granulosus Lysosomal Pro X carboxypeptidase 0.1897 0.5782 1
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0016 0.0006 0.001
Brugia malayi prolyl oligopeptidase family protein 0.0349 0.1027 0.327
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0105 0.1385
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.002 0.0034
Loa Loa (eye worm) hypothetical protein 0.0036 0.0068 0.0215
Loa Loa (eye worm) hypothetical protein 0.0016 0.0006 0.0018
Entamoeba histolytica hypothetical protein 0.0262 0.076 1
Trypanosoma cruzi oligopeptidase b 0.0082 0.0209 0.2032
Entamoeba histolytica prolyl oligopeptidase family protein 0.0082 0.0209 0.2748
Brugia malayi Ets-domain containing protein 0.0087 0.0225 0.0716
Brugia malayi prolyl oligopeptidase family protein 0.1037 0.3142 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0096 0.025 0.025
Entamoeba histolytica serine carboxypeptidase (S28) family protein 0.0102 0.0269 0.3545
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0105 0.1024
Echinococcus multilocularis mothers against decapentaplegic 6 0.0015 0.0002 0.0002
Loa Loa (eye worm) inositol-1 0.0075 0.0186 0.0593
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.002 0.0063
Loa Loa (eye worm) hypothetical protein 0.0036 0.0068 0.0215
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0016 0.0006 0.0018
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0016 0.0006 0.001
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0036 0.0068 1
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0349 0.1027 1
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0082 0.0209 0.2748
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0754 0.2271 0.5324
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.002 0.0034
Loa Loa (eye worm) hypothetical protein 0.0026 0.0037 0.0118
Brugia malayi nuclear hormone receptor 0.0021 0.002 0.0063
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0082 0.0209 0.1405
Echinococcus granulosus survival motor neuron protein 1 0.0712 0.2144 0.3708
Schistosoma mansoni survival motor neuron protein 0.0145 0.0403 0.0696
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0105 0.0335
Schistosoma mansoni voltage-gated potassium channel 0.0049 0.0106 0.0183
Entamoeba histolytica G protein alpha subunit, putative 0.0016 0.0006 0.0076
Echinococcus granulosus inositol monophosphatase 1 0.0075 0.0186 0.0322
Loa Loa (eye worm) hypothetical protein 0.0063 0.0149 0.0474
Echinococcus multilocularis serotonin receptor 0.0158 0.0442 0.0442
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0015 0.0103
Toxoplasma gondii ABC1 family protein 0.0118 0.0319 0.3101
Echinococcus granulosus FTZ F1 alpha 0.0021 0.002 0.0034
Entamoeba histolytica serine carboxypeptidase (S28) family protein 0.0102 0.0269 0.3545
Schistosoma mansoni alpha-glucosidase 0.0145 0.04 0.0692
Toxoplasma gondii prolyl endopeptidase 0.0082 0.0209 0.2032
Plasmodium falciparum ataxin-2 like protein, putative 0.0107 0.0286 1
Echinococcus multilocularis lamin dm0 0.0026 0.0037 0.0037
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0048 0.0105 0.0247
Mycobacterium tuberculosis Probable esterase LipL 0.0118 0.0319 0.0747
Onchocerca volvulus 0.0073 0.018 0.0574
Schistosoma mansoni cellular tumor antigen P53 0.0099 0.0261 0.0452
Entamoeba histolytica hypothetical protein, conserved 0.0082 0.0209 0.2748
Brugia malayi Fli-1 protein 0.0265 0.0772 0.2456
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0375 0.1109 0.1109
Entamoeba histolytica hypothetical protein 0.0262 0.076 1
Leishmania major protein kinase, putative 0.0017 0.0008 0.0079
Schistosoma mansoni tar DNA-binding protein 0.0202 0.0577 0.0998
Plasmodium falciparum ataxin-2 like protein, putative 0.0107 0.0286 1
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0037 0.0118
Brugia malayi TAR-binding protein 0.0202 0.0577 0.1837
Brugia malayi hypothetical protein 0.0712 0.2144 0.6824
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.1037 0.3142 0.3142
Schistosoma mansoni GTP-binding protein (I) alpha subunit gnai 0.0016 0.0006 0.001
Echinococcus multilocularis lysosomal alpha glucosidase 0.0168 0.0472 0.0472
Schistosoma mansoni aryl hydrocarbon receptor nuclear translocator homolog (darnt) 0.004 0.0078 0.0135
Trichomonas vaginalis D-aminoacylase, putative 0.0118 0.0319 0.2144
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0375 0.1109 0.1919
Echinococcus granulosus biogenic amine 5HT receptor 0.0158 0.0442 0.0764
Brugia malayi Pre-SET motif family protein 0.0063 0.0149 0.0474
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0017 0.0008 0.0055
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0118 0.0319 0.0551
Trypanosoma cruzi serine carboxypeptidase S28, putative 0.0102 0.0269 0.2622
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.002 0.0063
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0075 0.0186 0.1815
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0375 0.1109 0.3531
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0082 0.0209 0.0489
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0075 0.0186 0.1255
Onchocerca volvulus 0.0099 0.0261 0.0832
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0048 0.0105 0.0247
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0349 0.1027 1
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0016 0.0006 0.001
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0015 0.0015
Schistosoma mansoni family S28 unassigned peptidase (S28 family) 0.1897 0.5782 1
Onchocerca volvulus 0.0018 0.0012 0.0039
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.0071 0.0122
Schistosoma mansoni alpha glucosidase 0.0037 0.0071 0.0122
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0016 0.0006 0.001
Loa Loa (eye worm) hypothetical protein 0.0102 0.0269 0.0857
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.002 0.0034
Schistosoma mansoni hypothetical protein 0.0206 0.059 0.1021
Schistosoma mansoni hypothetical protein 0.0096 0.025 0.0432
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0042 0.0084 0.0566
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0118 0.0319 0.0747
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.004 0.0078 0.0248
Loa Loa (eye worm) serotonin transporter b 0.0073 0.018 0.0574
Giardia lamblia Alanyl dipeptidyl peptidase 0.0082 0.0209 0.7616
Trypanosoma cruzi prolyl endopeptidase 0.0082 0.0209 0.2032
Onchocerca volvulus 0.0145 0.0403 0.1281
Loa Loa (eye worm) MH2 domain-containing protein 0.0492 0.1467 0.4669
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.002 0.002
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0008 0.0055
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0082 0.0209 0.0361
Brugia malayi prolyl oligopeptidase family protein 0.0082 0.0209 0.0664
Echinococcus granulosus Lysosomal Pro X carboxypeptidase 0.0102 0.0269 0.0466
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.002 0.0063
Mycobacterium leprae conserved hypothetical protein 0.0118 0.0319 0.0747
Schistosoma mansoni Smad4 0.0015 0.0002 0.0004
Schistosoma mansoni intermediate filament proteins 0.0026 0.0037 0.0064
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0096 0.025 0.0795
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0017 0.0008 0.0079
Loa Loa (eye worm) solute carrier family 6 member 4 0.0073 0.018 0.0574
Echinococcus multilocularis neuropeptide s receptor 0.0466 0.1389 0.1389
Loa Loa (eye worm) hypothetical protein 0.0016 0.0006 0.0018
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0016 0.0006 0.001
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.002 0.0034
Loa Loa (eye worm) hypothetical protein 0.0096 0.025 0.0795
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR 0.1403 0.4265 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0015 0.0201
Mycobacterium tuberculosis Probable peptidase 0.0082 0.0209 0.0489
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0102 0.0269 0.1813
Brugia malayi hypothetical protein 0.0056 0.0129 0.0411
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0017 0.0008 0.0079
Entamoeba histolytica serine carboxypeptidase (S28) family protein 0.0102 0.0269 0.3545
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0071 0.0931
Loa Loa (eye worm) hypothetical protein 0.0118 0.0319 0.1014
Echinococcus granulosus acylamino acid releasing enzyme 0.0082 0.0209 0.0361
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0017 0.0008 0.0055
Schistosoma mansoni aryl hydrocarbon receptor 0.0017 0.0009 0.0016
Echinococcus multilocularis aryl hydrocarbon receptor 0.0057 0.013 0.013
Echinococcus multilocularis Smad4 0.0034 0.0059 0.0059
Brugia malayi Pre-SET motif family protein 0.0437 0.13 0.4137
Mycobacterium ulcerans hypothetical protein 0.0118 0.0319 0.0747
Loa Loa (eye worm) hypothetical protein 0.0107 0.0286 0.091
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.002 0.002
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0017 0.0008 0.0055
Loa Loa (eye worm) hypothetical protein 0.0073 0.018 0.0574
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.0016 0.0006 0.0018
Brugia malayi Serine carboxypeptidase S28 family protein 0.0102 0.0269 0.0857
Plasmodium vivax acyl-CoA synthetase, putative 0.0036 0.0068 0.2121
Onchocerca volvulus 0.0063 0.0149 0.0474
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0082 0.0209 0.2032
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0004 0.0014
Schistosoma mansoni smad1 5 8 and 0.0034 0.0059 0.0102
Schistosoma mansoni hypothetical protein 0.0165 0.0464 0.0803
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0004 0.0141
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0037 0.0071 0.0688
Schistosoma mansoni GTP-binding protein alpha subunit 0.0016 0.0006 0.001
Loa Loa (eye worm) MH1 domain-containing protein 0.0015 0.0002 0.0007
Loa Loa (eye worm) hypothetical protein 0.0048 0.0105 0.0335
Schistosoma mansoni sodium/chloride dependent transporter 0.0073 0.018 0.0312
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0071 0.0688
Brugia malayi aryl hydrocarbon receptor AHR-1 0.0039 0.0077 0.0246
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.0016 0.0006 0.001
Toxoplasma gondii LsmAD domain-containing protein 0.0107 0.0286 0.2782
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0015 0.048
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0075 0.0186 0.1255
Echinococcus granulosus smad 0.0034 0.0059 0.0102
Mycobacterium tuberculosis Probable hydrolase 0.0118 0.0319 0.0747
Echinococcus granulosus expressed protein 0.0016 0.0006 0.001
Echinococcus multilocularis neuropeptide receptor A26 0.0466 0.1389 0.1389
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0102 0.0269 0.1813
Echinococcus granulosus geminin 0.0165 0.0464 0.0803
Loa Loa (eye worm) MH2 domain-containing protein 0.0034 0.0059 0.0188
Echinococcus granulosus aryl hydrocarbon receptor 0.0057 0.013 0.0225
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0071 0.0931
Trichomonas vaginalis penicillin-binding protein, putative 0.0118 0.0319 0.2144
Trichomonas vaginalis GTP-binding protein (q) alpha-11 subunit, gna11, putative 0.0016 0.0006 0.0039
Loa Loa (eye worm) hypothetical protein 0.0118 0.0319 0.1014
Loa Loa (eye worm) hypothetical protein 0.0118 0.0319 0.1014
Schistosoma mansoni hypothetical protein 0.0096 0.025 0.0432
Loa Loa (eye worm) hypothetical protein 0.0159 0.0446 0.142
Trichomonas vaginalis guanylate cyclase, putative 0.0017 0.0008 0.0055
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0375 0.1109 0.1919
Schistosoma mansoni smad 0.0015 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0206 0.059 0.1879
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.0071 0.0225
Loa Loa (eye worm) hypothetical protein 0.0118 0.0319 0.1014
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0349 0.1027 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0375 0.1109 0.1109
Brugia malayi nuclear receptor NHR-88 0.0021 0.002 0.0063
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0082 0.0209 0.0361
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.0016 0.0006 0.0018
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0017 0.0009 0.0016
Onchocerca volvulus Prolyl endopeptidase homolog 0.0082 0.0209 0.0664
Echinococcus granulosus Dipeptidyl peptidase 9 0.0349 0.1027 0.1777
Echinococcus granulosus histone lysine methyltransferase setb 0.0063 0.0149 0.0258
Echinococcus multilocularis musashi 0.0026 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0039 0.0075 0.0239
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0071 0.0476
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0075 0.0186 1
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0082 0.0209 0.0361
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0075 0.0186 0.1815
Brugia malayi RNA recognition motif domain containing protein 0.0202 0.0577 0.1837
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0075 0.0186 0.1815
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.002 0.0063
Echinococcus multilocularis mothers against decapentaplegic 2 0.0015 0.0002 0.0002
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0017 0.0009 0.0009
Onchocerca volvulus 0.0048 0.0105 0.0335
Echinococcus multilocularis inositol monophosphatase 1 0.0075 0.0186 0.0186
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0063
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0037 0.0118
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0102 0.0269 0.1813
Mycobacterium ulcerans beta-lactamase 0.0118 0.0319 0.0747
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0063 0.0149 0.0258
Brugia malayi prolyl oligopeptidase family protein 0.0082 0.0209 0.0664
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0102 0.0269 0.1813
Schistosoma mansoni smad 0.0034 0.0059 0.0102
Onchocerca volvulus 0.0021 0.002 0.0063
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0071 0.0476
Schistosoma mansoni smad1 5 8 and 0.0034 0.0059 0.0102
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0004 0.0004
Trypanosoma brucei oligopeptidase b 0.0082 0.0209 0.2032
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0048 0.0104 0.0104
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0061 0.0144
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0036 0.0068 0.0158
Trypanosoma brucei prolyl oligopeptidase, putative 0.0082 0.0209 0.2032
Entamoeba histolytica prolyl oligopeptidase family protein 0.0082 0.0209 0.2748
Brugia malayi beta-lactamase family protein 0.0118 0.0319 0.1014
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.002 0.0063
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.0016 0.0006 0.0018
Brugia malayi RNA binding protein 0.0202 0.0577 0.1837
Entamoeba histolytica hypothetical protein 0.0262 0.076 1
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0037 0.0118
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0017 0.0008 0.0055
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0061 0.0144
Plasmodium vivax hypothetical protein, conserved 0.0118 0.0319 1
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0082 0.0209 0.2032
Brugia malayi prolyl oligopeptidase family protein 0.0082 0.0209 0.0664
Brugia malayi MH2 domain containing protein 0.0492 0.1467 0.4669
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0071 0.0476
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0004 0.0157
Schistosoma mansoni lamin 0.0026 0.0037 0.0064
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0118 0.0319 0.0747
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.002 0.0034
Loa Loa (eye worm) hypothetical protein 0.0368 0.1087 0.346
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0073 0.018 0.0574
Loa Loa (eye worm) hypothetical protein 0.0026 0.0036 0.0113
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0349 0.1027 1
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0082 0.0209 0.0489
Onchocerca volvulus 0.0118 0.0319 0.1014
Mycobacterium tuberculosis Conserved protein 0.0118 0.0319 0.0747
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0004 0.0044
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0061 0.0144
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0082 0.0209 0.2032
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0004 0.0044
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.0016 0.0006 0.0018
Entamoeba histolytica hypothetical protein 0.0262 0.076 1
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0105 0.0335
Brugia malayi Latrophilin receptor protein 2 0.0096 0.025 0.0795
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0082 0.0209 0.2032
Brugia malayi aryl hydrocarbon receptor nuclear translocator protein, putative 0.0044 0.0091 0.0288
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0096 0.025 0.0432
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0105 0.1024
Schistosoma mansoni inositol monophosphatase 0.0075 0.0186 0.0322
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0017 0.0008 0.0079
Schistosoma mansoni smad1 5 8 and 0.0034 0.0059 0.0102
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.002 0.0034
Schistosoma mansoni ap endonuclease 0.0019 0.0015 0.0026
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0071 0.0476
Echinococcus granulosus beta LACTamase domain containing family member 0.0118 0.0319 0.0551
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0057 0.013 0.0414
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0048 0.0104 0.018
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.1037 0.3142 1
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0004 0.0008
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0061 0.0144
Echinococcus granulosus lamin 0.0026 0.0037 0.0064
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0004 0.0044
Mycobacterium tuberculosis Conserved protein 0.0118 0.0319 0.0747
Leishmania major oligopeptidase b 0.0082 0.0209 0.2032
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0015 0.0049
Trichomonas vaginalis GTP-binding protein (O) alpha subunit, gnao, putative 0.0016 0.0006 0.0039
Loa Loa (eye worm) hypothetical protein 0.0102 0.0269 0.0857
Schistosoma mansoni biogenic amine (5HT) receptor 0.0158 0.0442 0.0764
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0008 0.0055
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0063
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0004 0.0044
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0118 0.0319 0.0747
Toxoplasma gondii serine carboxypeptidase s28 protein 0.0102 0.0269 0.2622
Onchocerca volvulus 0.0026 0.0037 0.0118
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.0016 0.0006 0.0018
Plasmodium falciparum peptidase, putative 0.0082 0.0209 0.7304
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.0016 0.0006 0.0018
Echinococcus multilocularis survival motor neuron protein 1 0.0712 0.2144 0.2144
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0375 0.1109 0.1919
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.0105 0.0247
Brugia malayi MH1 domain containing protein 0.0019 0.0013 0.0042
Treponema pallidum sodium- and chloride- dependent transporter 0.0073 0.018 1
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0004 0.0044
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0105 0.1024
Echinococcus granulosus prolyl endopeptidase 0.0082 0.0209 0.0361
Loa Loa (eye worm) hypothetical protein 0.0102 0.0269 0.0857
Trypanosoma cruzi hypothetical protein, conserved 0.0118 0.0319 0.3101
Loa Loa (eye worm) hypothetical protein 0.0073 0.018 0.0574
Loa Loa (eye worm) hypothetical protein 0.0039 0.0077 0.0246
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0016 0.0006 0.001
Echinococcus granulosus tar DNA binding protein 0.0202 0.0577 0.0998
Onchocerca volvulus 0.0016 0.0006 0.0018
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.0071 0.0225
Brugia malayi hypothetical protein 0.0069 0.0169 0.0538
Schistosoma mansoni hypothetical protein 0.0096 0.025 0.0432
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0048 0.0105 0.0247
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0015 0.0103
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.002 0.0034
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0042
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.002 0.0063
Leishmania major protein kinase, putative 0.0023 0.0026 0.0255
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.002 0.0063
Schistosoma mansoni Smad4 0.0034 0.0059 0.0102
Echinococcus granulosus lysosomal alpha glucosidase 0.0168 0.0472 0.0816
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0302 0.0884 0.2813
Brugia malayi Serine protease Z688.6 precursor 0.0102 0.0269 0.0857
Echinococcus multilocularis Lysosomal Pro X carboxypeptidase 0.1897 0.5782 0.5782
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0375 0.1109 0.1919
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0004 0.0014
Trypanosoma cruzi hypothetical protein, conserved 0.0082 0.0209 0.2032
Schistosoma mansoni inositol monophosphatase 0.0075 0.0186 0.0322
Echinococcus multilocularis GPCR, family 2 0.0096 0.025 0.025
Loa Loa (eye worm) hypothetical protein 0.0082 0.0209 0.0664
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0375 0.1109 0.1919
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0349 0.1027 0.1027
Loa Loa (eye worm) hypothetical protein 0.0082 0.0209 0.0664
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0149 0.0258
Brugia malayi MH1 domain containing protein 0.0034 0.0059 0.0188
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.1037 0.3142 0.5434
Schistosoma mansoni ets-related 0.0265 0.0772 0.1335
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0004 0.001
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.002 0.0063
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.002 0.002
Brugia malayi beta-lactamase 0.0118 0.0319 0.1014
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0071 0.0476
Brugia malayi intermediate filament protein 0.0026 0.0037 0.0118
Echinococcus granulosus intermediate filament protein 0.0026 0.0037 0.0064
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0149 0.0258
Echinococcus multilocularis lamin 0.0026 0.0037 0.0037
Echinococcus multilocularis geminin 0.0165 0.0464 0.0464
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0102 0.0269 0.1813
Loa Loa (eye worm) hypothetical protein 0.0039 0.0077 0.0246
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.002 0.0063
Loa Loa (eye worm) hypothetical protein 0.0015 0.0002 0.0007
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0016 0.0006 0.001
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0102 0.0269 0.1813
Schistosoma mansoni lysosomal Pro-Xaa carboxypeptidase (S28 family) 0.0102 0.0269 0.0466
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0262 0.076 0.1314
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0075 0.0186 0.1815
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.002 0.0063
Onchocerca volvulus 0.0016 0.0006 0.0018
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0016 0.0006 0.0039
Plasmodium vivax ataxin-2 like protein, putative 0.0107 0.0286 0.8972
Brugia malayi Inositol-1 0.0075 0.0186 0.0593
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.002 0.0034
Plasmodium falciparum acyl-CoA synthetase 0.0036 0.0068 0.2364
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0168 0.0472 0.1502
Schistosoma mansoni gabp alpha 0.0087 0.0225 0.0389
Brugia malayi MH1 domain containing protein 0.0019 0.0013 0.0042
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0015 0.0149
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0015 0.0535
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0063 0.0149 0.0149
Mycobacterium ulcerans transcriptional regulator 0.1403 0.4265 1
Echinococcus granulosus mothers against decapentaplegic 6 0.0015 0.0002 0.0004
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.0105 0.0247
Onchocerca volvulus 0.0159 0.0446 0.142
Schistosoma mansoni GTP-binding protein alpha subunit 0.0016 0.0006 0.001
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0118 0.0319 0.1014
Echinococcus granulosus serotonin transporter 0.0073 0.018 0.0312
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.002 0.0063
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0349 0.1027 1
Loa Loa (eye worm) hypothetical protein 0.0302 0.0884 0.2813
Schistosoma mansoni Smad4 0.0015 0.0002 0.0004
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0102 0.0269 0.1813
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0105 0.0335
Onchocerca volvulus 0.0016 0.0006 0.0018
Loa Loa (eye worm) hypothetical protein 0.0118 0.0319 0.1014
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0063
Brugia malayi MH2 domain containing protein 0.0015 0.0002 0.0007
Trichomonas vaginalis guanylate cyclase, putative 0.0017 0.0008 0.0055
Loa Loa (eye worm) MH2 domain-containing protein 0.0015 0.0002 0.0007
Loa Loa (eye worm) hypothetical protein 0.0266 0.0775 0.2466
Trypanosoma cruzi PAB1-binding protein , putative 0.0107 0.0286 0.2782
Schistosoma mansoni coup transcription factor 0.0021 0.002 0.0034
Loa Loa (eye worm) MH1 domain-containing protein 0.0034 0.0059 0.0188
Trichomonas vaginalis penicillin-binding protein, putative 0.0118 0.0319 0.2144
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.002 0.0063
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.002 0.0063
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.002 0.0063
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0087 0.0225 0.0716
Leishmania major alpha glucosidase II subunit, putative 0.0037 0.0071 0.0688
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0004 0.0044
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.002 0.0034
Giardia lamblia Thymus-specific serine protease precursor 0.0102 0.0269 1
Schistosoma mansoni ap endonuclease 0.0019 0.0015 0.0026
Echinococcus multilocularis lysosomal alpha glucosidase 0.0168 0.0472 0.0472
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.0016 0.0006 0.0006
Echinococcus granulosus mothers against decapentaplegic 2 0.0015 0.0002 0.0004
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.006 0.0142 0.0245
Echinococcus multilocularis acylamino acid releasing enzyme 0.0082 0.0209 0.0209
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0082 0.0209 0.2032
Loa Loa (eye worm) hypothetical protein 0.0099 0.0261 0.0832
Echinococcus multilocularis mothers against decapentaplegic 5 0.0034 0.0059 0.0059
Trichomonas vaginalis lysosomal pro-X carboxypeptidase, putative 0.0102 0.0269 0.1813
Brugia malayi hypothetical protein 0.0107 0.0286 0.091
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.002 0.0063
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0048 0.0105 0.0247
Echinococcus granulosus tumor protein p63 0.0679 0.2041 0.3529
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0262 0.076 0.076
Mycobacterium tuberculosis Probable lipase LipE 0.0118 0.0319 0.0747
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.002 0.0063
Toxoplasma gondii hypothetical protein 0.0082 0.0209 0.2032
Loa Loa (eye worm) hypothetical protein 0.0039 0.0077 0.0246
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0016 0.0006 0.001
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0071 0.0688
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0015 0.0036
Trypanosoma cruzi serine carboxypeptidase S28, putative 0.0102 0.0269 0.2622
Schistosoma mansoni hypothetical protein 0.0165 0.0464 0.0803
Brugia malayi steroid hormone receptor 0.0021 0.002 0.0063
Onchocerca volvulus 0.0102 0.0269 0.0857
Echinococcus granulosus mothers against decapentaplegic 5 0.0034 0.0059 0.0102
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0016 0.0006 0.0006
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0048 0.0105 0.0247
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0045 0.0093 0.0296
Echinococcus granulosus lamin dm0 0.0026 0.0037 0.0064
Echinococcus multilocularis tumor protein p63 0.0679 0.2041 0.2041
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.002 0.0063
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0036 0.0068 0.0158
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0102 0.0269 0.1813
Giardia lamblia Serine peptidase, putative 0.0102 0.0269 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0004 0.0004
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0063 0.0149 0.145
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0004 0.0044
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0071 0.0476
Loa Loa (eye worm) G protein alpha subunit 3 0.0016 0.0006 0.0018
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0016 0.0006 0.001
Toxoplasma gondii exonuclease III APE 0.0019 0.0015 0.0149
Onchocerca volvulus 0.0097 0.0255 0.081
Loa Loa (eye worm) hypothetical protein 0.0017 0.0008 0.0026
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0096 0.025 0.0432
Onchocerca volvulus 0.0118 0.0319 0.1014
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0349 0.1027 0.1777
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0063
Trichomonas vaginalis D-aminoacylase, putative 0.0118 0.0319 0.2144
Mycobacterium ulcerans lipase LipD 0.0118 0.0319 0.0747
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0071 0.0476
Trichomonas vaginalis prolylcarboxypeptidase, putative 0.0102 0.0269 0.1813
Entamoeba histolytica prolyl oligopeptidase family protein 0.0082 0.0209 0.2748
Trichomonas vaginalis GTP-binding protein (z) alpha subunit, gnaz, putative 0.0016 0.0006 0.0039
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0118 0.0319 0.1014
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.002 0.002
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0082 0.0209 0.2032
Trichomonas vaginalis prolylcarboxypeptidase, putative 0.0102 0.0269 0.1813
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0004 0.0004
Brugia malayi beta-lactamase family protein 0.0118 0.0319 0.1014
Trypanosoma brucei prolyl endopeptidase 0.0082 0.0209 0.2032
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0063
Loa Loa (eye worm) hypothetical protein 0.0158 0.0442 0.1406
Loa Loa (eye worm) hypothetical protein 0.0073 0.018 0.0574
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.0016 0.0006 0.0018
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0102 0.0269 0.1813
Loa Loa (eye worm) hypothetical protein 0.0016 0.0006 0.0018
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0082 0.0209 0.0361
Echinococcus multilocularis serotonin receptor 0.0158 0.0442 0.0442
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.002 0.0034
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0016 0.0006 0.0006
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0048 0.0105 0.0335
Loa Loa (eye worm) beta-lactamase 0.0118 0.0319 0.1014
Trichomonas vaginalis inositol monophosphatase, putative 0.0075 0.0186 0.1255
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.002 0.0063
Trichomonas vaginalis G protein (olf) alpha subunit, gnal, putative 0.0016 0.0006 0.0039
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0015 0.0026
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0202 0.0577 0.1837
Onchocerca volvulus 0.0056 0.0129 0.0411
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0368 0.1087 0.346
Giardia lamblia Alanyl dipeptidyl peptidase 0.0082 0.0209 0.7616
Brugia malayi G-protein alpha subunit 0.0016 0.0006 0.0018
Echinococcus multilocularis smad 0.0034 0.0059 0.0059

Activities

Activity type Activity value Assay description Source Reference
EC50 (binding) = 6.4 Agonist activity at human 5-HT1B receptor expressed in CHO cells assessed as stimulation of GTPgammaS binding by scintillation proximity assay ChEMBL. 20951584
Intrinsic activity (binding) = 0 Intrinsic activity at human 5-HT1A receptor expressed in HEK293 cells assessed as effect on GTPgammaS binding by scintillation proximity assay relative to 5HT ChEMBL. 20951584
Intrinsic activity (binding) = 0 Intrinsic activity at human 5-HT1D receptor expressed in CHO cells assessed as effect on GTPgammaS binding by scintillation proximity assay relative to 5HT ChEMBL. 20951584
Intrinsic activity (binding) = 0.4 Intrinsic activity at human 5-HT1B receptor expressed in CHO cells assessed as effect on GTPgammaS binding by scintillation proximity assay relative to 5HT ChEMBL. 20951584
Ki (binding) = 6.1 Displacement of [3H]-dofetilide in human ERG expressed in CHO cells by proximity assay ChEMBL. 20951584
Ki (binding) = 7.6 Displacement of [3H]-citalopram in human SERT expressed in LLCPK cells by filtration assay ChEMBL. 20951584
Ki (functional) = 9 Antagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assay ChEMBL. 20951584
Ki (functional) = 9.2 Antagonist activity at human 5-HT1A receptor expressed in HEK293 cells assessed as inhibition of GTPgammaS binding by scintillation proximity assay ChEMBL. 20951584

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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