Detailed information for compound 1279934

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 346.854 | Formula: C18H23ClN4O
  • H donors: 1 H acceptors: 2 LogP: 3.29 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCNC(=O)N1CCN(CC1)c1ccnc2c1ccc(c2)Cl
  • InChi: 1S/C18H23ClN4O/c1-2-3-7-21-18(24)23-11-9-22(10-12-23)17-6-8-20-16-13-14(19)4-5-15(16)17/h4-6,8,13H,2-3,7,9-12H2,1H3,(H,21,24)
  • InChiKey: ZPMLDXVANWTUCU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens v-ets avian erythroblastosis virus E26 oncogene homolog Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Candida dubliniensis (strain CD36 / CBS 7987 / NCPF 3949 / NRRLY-17841) (Yeast) Serine/threonine-protein phosphatase Starlite/ChEMBL No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum expressed protein Get druggable targets OG5_127131 All targets in OG5_127131
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127131 All targets in OG5_127131
Plasmodium vivax serine/threonine protein phosphatase 2B catalytic subunit A, putative Get druggable targets OG5_127131 All targets in OG5_127131
Trypanosoma congolense protein phosphatase 2B, putative Get druggable targets OG5_127131 All targets in OG5_127131
Leishmania major serine/threonine protein phosphatase 2B catalytic subunit A2, putative Get druggable targets OG5_127131 All targets in OG5_127131
Schistosoma japonicum Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform, putative Get druggable targets OG5_127131 All targets in OG5_127131
Echinococcus granulosus serine:threonine protein phosphatase 2B Get druggable targets OG5_127131 All targets in OG5_127131
Schistosoma mansoni ets-related Get druggable targets OG5_131947 All targets in OG5_131947
Leishmania mexicana serine/threonine protein phosphatase 2B catalytic subunit A2, putative Get druggable targets OG5_127131 All targets in OG5_127131
Entamoeba histolytica calcineurin catalytic subunit A, putative Get druggable targets OG5_127131 All targets in OG5_127131
Entamoeba histolytica Ser/Thr protein phosphatase, putative Get druggable targets OG5_127131 All targets in OG5_127131
Plasmodium knowlesi serine/threonine protein phosphatase 2B catalytic subunit A, putative Get druggable targets OG5_127131 All targets in OG5_127131
Trypanosoma cruzi serine/threonine protein phosphatase, putative Get druggable targets OG5_127131 All targets in OG5_127131
Candida albicans similar to calcineurin-like protein serine/threonine protein phosphatase Get druggable targets OG5_127131 All targets in OG5_127131
Leishmania infantum serine/threonine protein phosphatase 2B catalytic subunit A2, putative Get druggable targets OG5_127131 All targets in OG5_127131
Plasmodium berghei serine/threonine protein phosphatase 2B catalytic subunit A Get druggable targets OG5_127131 All targets in OG5_127131
Brugia malayi Serine/threonine protein phosphatase 2B catalytic subunit 2 Get druggable targets OG5_127131 All targets in OG5_127131
Trypanosoma brucei gambiense serine/threonine protein phosphatase 2B catalytic subunit A2, putative Get druggable targets OG5_127131 All targets in OG5_127131
Plasmodium yoelii protein phosphatase 2B-related Get druggable targets OG5_127131 All targets in OG5_127131
Echinococcus multilocularis serine:threonine protein phosphatase 2B Get druggable targets OG5_127131 All targets in OG5_127131
Entamoeba histolytica calcineurin catalytic subunit A, putative Get druggable targets OG5_127131 All targets in OG5_127131
Cryptosporidium parvum protein phosphatase 2B catalytic subunit, calcineurin like phosphatse superfamily Get druggable targets OG5_127131 All targets in OG5_127131
Brugia malayi Fli-1 protein Get druggable targets OG5_131947 All targets in OG5_131947
Leishmania major serine/threonine protein phosphatase, putative Get druggable targets OG5_127131 All targets in OG5_127131
Trypanosoma brucei protein phosphatase 2B, putative Get druggable targets OG5_127131 All targets in OG5_127131
Trypanosoma cruzi serine/threonine protein phosphatase, putative Get druggable targets OG5_127131 All targets in OG5_127131
Schistosoma japonicum Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform, putative Get druggable targets OG5_127131 All targets in OG5_127131
Candida albicans potential calcineurin-like protein serine/threonine protein phosphatase Get druggable targets OG5_127131 All targets in OG5_127131
Entamoeba histolytica calcineurin catalytic subunit A, putative Get druggable targets OG5_127131 All targets in OG5_127131
Cryptosporidium hominis protein phosphatase 2b Get druggable targets OG5_127131 All targets in OG5_127131
Echinococcus granulosus serine:threonine protein phosphatase 2B Get druggable targets OG5_127131 All targets in OG5_127131
Schistosoma japonicum Serine/threonine-protein phosphatase 2B catalytic subunit 3, putative Get druggable targets OG5_127131 All targets in OG5_127131
Schistosoma japonicum ko:K09435 transcriptional regulator ERG, putative Get druggable targets OG5_131947 All targets in OG5_131947
Leishmania donovani serine/threonine protein phosphatase 2B catalytic subunit A2, putative Get druggable targets OG5_127131 All targets in OG5_127131
Loa Loa (eye worm) fli-1 protein Get druggable targets OG5_131947 All targets in OG5_131947
Schistosoma japonicum Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform, putative Get druggable targets OG5_127131 All targets in OG5_127131
Schistosoma japonicum ko:K04348 protein phosphatase 3, catalytic subunit, putative Get druggable targets OG5_127131 All targets in OG5_127131
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127131 All targets in OG5_127131
Neospora caninum serine/threonine protein phosphatase, putative Get druggable targets OG5_127131 All targets in OG5_127131
Schistosoma mansoni protein phosphatase-2b Get druggable targets OG5_127131 All targets in OG5_127131
Leishmania braziliensis serine/threonine protein phosphatase, putative Get druggable targets OG5_127131 All targets in OG5_127131
Echinococcus multilocularis serine:threonine protein phosphatase 2B Get druggable targets OG5_127131 All targets in OG5_127131
Leishmania braziliensis serine/threonine protein phosphatase 2B catalytic subunit A2, putative Get druggable targets OG5_127131 All targets in OG5_127131
Trypanosoma cruzi serine/threonine protein phosphatase 2B catalytic subunit A2, putative Get druggable targets OG5_127131 All targets in OG5_127131
Leishmania donovani serine/threonine protein phosphatase, putative Get druggable targets OG5_127131 All targets in OG5_127131
Leishmania infantum serine/threonine protein phosphatase, putative Get druggable targets OG5_127131 All targets in OG5_127131
Toxoplasma gondii protein phosphatase 2B catalytic subunit, calcineurin family phosphatse superfamily protein Get druggable targets OG5_127131 All targets in OG5_127131
Schistosoma mansoni protein phosphatase-2b Get druggable targets OG5_127131 All targets in OG5_127131
Plasmodium falciparum serine/threonine protein phosphatase 2B catalytic subunit A Get druggable targets OG5_127131 All targets in OG5_127131
Entamoeba histolytica calcineurin catalytic subunit A, putative Get druggable targets OG5_127131 All targets in OG5_127131
Leishmania mexicana serine/threonine protein phosphatase, putative Get druggable targets OG5_127131 All targets in OG5_127131
Entamoeba histolytica Ser/Thr protein phosphatase, putative Get druggable targets OG5_127131 All targets in OG5_127131
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Conserved protein 0.0037 0.0022 0.0019
Loa Loa (eye worm) hypothetical protein 0.0037 0.0022 0.0506
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0024 0.0009 0.016
Plasmodium vivax heterochromatin protein 1, putative 0.0024 0.0009 0.174
Schistosoma mansoni hypothetical protein 0.0389 0.0379 0.5737
Echinococcus multilocularis lamin dm0 0.0026 0.0011 0.0105
Echinococcus multilocularis serine:threonine protein phosphatase 2B 0.0051 0.0036 0.0373
Schistosoma mansoni protein phosphatase-2b 0.0051 0.0036 0.0525
Brugia malayi nuclear hormone receptor family member odr-7 0.002 0.0004 0.0056
Plasmodium falciparum histone acetyltransferase GCN5 0.004 0.0025 0.6622
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0007 0.1926
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0018 0.4991
Schistosoma mansoni single-minded 0.0018 0.0003 0.0026
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.002 0.0004 0.0049
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0012 0.2705
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0009 0.0273
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0118 0.0104 0.1558
Schistosoma mansoni protein phosphatase-2b 0.0051 0.0036 0.0525
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.001 0.0008
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0024 0.0009 0.0113
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0036 0.2206
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.002 0.0004 0.0035
Brugia malayi Latrophilin receptor protein 2 0.0118 0.0104 0.2536
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0007 0.1926
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.0004 0.0001
Loa Loa (eye worm) hypothetical protein 0.0042 0.0027 0.0636
Giardia lamblia Kinase, CMGC MAPK 0.0051 0.0036 1
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0022 0.1232
Loa Loa (eye worm) hypothetical protein 0.0043 0.0028 0.0668
Echinococcus granulosus serine:threonine protein phosphatase 2B 0.0051 0.0036 0.0525
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.001 0.0007
Echinococcus multilocularis Chromobox protein 3 0.0024 0.0009 0.008
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0043 0.2655
Leishmania major hypothetical protein, conserved 0.0037 0.0022 0.5586
Echinococcus multilocularis geminin 0.0389 0.0379 0.4074
Loa Loa (eye worm) hypothetical protein 0.0024 0.0009 0.0185
Trichomonas vaginalis chromobox protein, putative 0.0145 0.0132 0.8543
Schistosoma mansoni ferritin 0.0064 0.0049 0.0728
Onchocerca volvulus Protein cycle homolog 0.0043 0.0028 0.0583
Loa Loa (eye worm) hypothetical protein 0.0024 0.0009 0.0185
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0043 0.0028 0.0636
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0024 0.0009 0.1918
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0024 0.0009 0.1716
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0026 0.0011 0.0141
Echinococcus granulosus dna polymerase eta 0.0022 0.0007 0.0088
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0009 0.0379
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.0036 0.0532
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0009 0.0379
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0042 0.0027 0.0613
Brugia malayi Bromodomain containing protein 0.0076 0.0062 0.1481
Loa Loa (eye worm) helicase 0.0024 0.0009 0.0185
Entamoeba histolytica Ran family GTPase 0.0024 0.0009 0.0301
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0144 0.013 0.3206
Loa Loa (eye worm) hypothetical protein 0.002 0.0004 0.0081
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0022 0.1232
Echinococcus multilocularis Niemann Pick C1 protein 0.0225 0.0212 0.2275
Loa Loa (eye worm) hypothetical protein 0.0042 0.0027 0.0636
Loa Loa (eye worm) hypothetical protein 0.002 0.0004 0.0081
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.001 0.0352
Brugia malayi hypothetical protein 0.002 0.0004 0.0056
Loa Loa (eye worm) hypothetical protein 0.0042 0.0027 0.0652
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0051 0.0036 1
Brugia malayi nuclear receptor RXR 0.002 0.0004 0.0056
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0042 0.0027 0.0613
Loa Loa (eye worm) transcription factor SMAD2 0.0115 0.0101 0.2492
Trichomonas vaginalis chromobox protein, putative 0.0024 0.0009 0.0379
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0022 0.0007 0.1221
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0024 0.0009 0.1716
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0022 0.0019
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0042 0.0027 0.0388
Loa Loa (eye worm) hypothetical protein 0.0075 0.006 0.147
Brugia malayi nuclear hormone receptor 0.002 0.0004 0.0056
Brugia malayi Valyl-tRNA synthetase 0.0024 0.0009 0.016
Entamoeba histolytica hypothetical protein 0.0043 0.0029 0.1224
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0036 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0007 0.014
Loa Loa (eye worm) hypothetical protein 0.0082 0.0067 0.1641
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0042 0.0027 0.0388
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0009 0.0379
Brugia malayi MH2 domain containing protein 0.0115 0.0101 0.2474
Brugia malayi hypothetical protein 0.0027 0.0012 0.0242
Loa Loa (eye worm) nuclear hormone receptor 0.002 0.0004 0.0081
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0022 0.0007 0.0088
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0007 0.1926
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0051 0.0036 1
Brugia malayi hypothetical protein 0.0022 0.0007 0.0115
Entamoeba histolytica Ser/Thr protein phosphatase, putative 0.0051 0.0036 0.1569
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0064 0.0049 0.0046
Echinococcus multilocularis expressed conserved protein 0.0211 0.0199 0.2126
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0009 0.0379
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0082 0.0067 0.1573
Trichomonas vaginalis chromobox protein, putative 0.0088 0.0073 0.4669
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0012 0.0584
Trypanosoma brucei protein phosphatase 2B, putative 0.0051 0.0036 0.9875
Echinococcus multilocularis lamin 0.0026 0.0011 0.0105
Loa Loa (eye worm) hypothetical protein 0.0024 0.0009 0.0185
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0024 0.0009 0.0175
Onchocerca volvulus 0.0037 0.0022 0.0428
Echinococcus granulosus Chromo domain 0.0024 0.0009 0.0113
Schistosoma mansoni ap endonuclease 0.0018 0.0003 0.0026
Loa Loa (eye worm) hypothetical protein 0.0118 0.0104 0.2564
Entamoeba histolytica Ser/Thr protein phosphatase, putative 0.0051 0.0036 0.1569
Echinococcus multilocularis importin subunit beta 1 0.0033 0.0018 0.0182
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0024 0.0009 0.0113
Brugia malayi beta-lactamase family protein 0.0037 0.0022 0.0482
Brugia malayi intermediate filament protein 0.0026 0.0011 0.0217
Echinococcus multilocularis neuropeptide receptor A26 0.0447 0.0437 0.47
Echinococcus granulosus chromobox protein 1 0.0145 0.0132 0.1984
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0007 0.1926
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0009 0.0273
Echinococcus multilocularis ferritin 0.0064 0.0049 0.0517
Echinococcus multilocularis chromobox protein 2 0.0024 0.0009 0.008
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0154 0.0141 0.2119
Echinococcus multilocularis mitogen activated protein kinase 0.0051 0.0036 0.0378
Mycobacterium ulcerans TetR family transcriptional regulator 0.9877 1 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0321 0.031 0.3329
Loa Loa (eye worm) hypothetical protein 0.002 0.0004 0.0081
Schistosoma mansoni nuclear hormone receptor 0.0042 0.0027 0.0388
Schistosoma mansoni RAR-like nuclear receptor 0.0042 0.0027 0.0388
Loa Loa (eye worm) hypothetical protein 0.0045 0.003 0.0714
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0042 0.0027 0.0276
Loa Loa (eye worm) fli-1 protein 0.0265 0.0254 0.6279
Loa Loa (eye worm) hypothetical protein 0.0172 0.0159 0.3918
Loa Loa (eye worm) hypothetical protein 0.0042 0.0027 0.0636
Loa Loa (eye worm) hypothetical protein 0.0118 0.0104 0.2554
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0022 0.0007 0.014
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0011 0.0241
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0042 0.0027 0.0613
Loa Loa (eye worm) hypothetical protein 0.005 0.0035 0.0842
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0022 0.0308
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0007 0.0004
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0024 0.0009 0.174
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0022 0.0007 0.0062
Leishmania major GTP-binding protein, putative 0.0024 0.0009 0.1893
Brugia malayi M-phase phosphoprotein, mpp8 0.0024 0.0009 0.016
Entamoeba histolytica hypothetical protein 0.0024 0.0009 0.0273
Onchocerca volvulus 0.0026 0.0011 0.0162
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0118 0.0104 0.1107
Trichomonas vaginalis DNA polymerase eta, putative 0.0022 0.0007 0.0269
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.0004 0.0261
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0064
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0024 0.0009 0.0113
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0149 0.0136 0.1451
Echinococcus granulosus aryl hydrocarbon receptor 0.0061 0.0046 0.0681
Trichomonas vaginalis ran, putative 0.0024 0.0009 0.0418
Loa Loa (eye worm) hypothetical protein 0.0025 0.001 0.0226
Schistosoma mansoni ap endonuclease 0.0018 0.0003 0.0026
Trichomonas vaginalis conserved hypothetical protein 0.0082 0.0067 0.4253
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0118 0.0104 0.1107
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.002 0.0004 0.0035
Loa Loa (eye worm) hypothetical protein 0.0068 0.0054 0.1307
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0042 0.0027 0.0613
Schistosoma mansoni chromobox protein 0.0024 0.0009 0.0113
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0154 0.0141 0.1505
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0154 0.0141 0.3457
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0019 0.0003 0.014
Brugia malayi MAP kinase sur-1 0.0051 0.0036 0.0849
Loa Loa (eye worm) beta-lactamase 0.0037 0.0022 0.0506
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0003 0.0001
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.0005 0.0106
Echinococcus granulosus Protein patched homolog 1 0.0096 0.0082 0.123
Echinococcus granulosus Nuclear hormone receptor HR96 0.002 0.0004 0.0049
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.0007 0.0058
Schistosoma mansoni aryl hydrocarbon receptor 0.0018 0.0003 0.0031
Onchocerca volvulus 0.0057 0.0042 0.0945
Echinococcus multilocularis ecdysone induced protein 78C 0.0042 0.0027 0.0276
Trichomonas vaginalis chromobox protein, putative 0.0024 0.0009 0.0379
Schistosoma mansoni lamin 0.0026 0.0011 0.0147
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0029 0.0415
Schistosoma mansoni hypothetical protein 0.0118 0.0104 0.1558
Echinococcus granulosus zinc finger protein 0.0023 0.0007 0.0093
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0009 0.0379
Echinococcus multilocularis zinc finger protein 0.0023 0.0007 0.0066
Giardia lamblia Histone acetyltransferase GCN5 0.004 0.0025 0.6532
Loa Loa (eye worm) hypothetical protein 0.0037 0.0022 0.0506
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0019 0.0003 0.014
Echinococcus granulosus microtubule associated protein 2 0.0667 0.066 1
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0019 0.0004 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0064
Schistosoma mansoni nuclear hormone receptor 0.002 0.0004 0.0049
Echinococcus granulosus serine:threonine protein phosphatase 2B 0.0051 0.0036 0.0525
Entamoeba histolytica calcineurin catalytic subunit A, putative 0.0051 0.0036 0.1569
Trichomonas vaginalis chromobox protein, putative 0.0145 0.0132 0.8543
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0009 0.0379
Echinococcus multilocularis thyroid hormone receptor alpha 0.0042 0.0027 0.0276
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0007 0.1926
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0064 0.0049 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.001 0.0226
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0042 0.0027 0.0388
Echinococcus granulosus Nuclear hormone receptor HR96 0.002 0.0004 0.0049
Loa Loa (eye worm) hypothetical protein 0.002 0.0004 0.0081
Loa Loa (eye worm) heterochromatin protein 1 0.0145 0.0132 0.3252
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0022 0.0308
Echinococcus granulosus mitogen activated protein kinase 3 0.0051 0.0036 0.0532
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0042 0.0027 0.0388
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0012 0.0584
Loa Loa (eye worm) hypothetical protein 0.0024 0.0009 0.0185
Echinococcus multilocularis Nuclear hormone receptor HR96 0.002 0.0004 0.0035
Echinococcus granulosus GTP binding nuclear protein Ran 0.0024 0.0009 0.0122
Schistosoma mansoni ferritin light chain 0.0064 0.0049 0.0728
Brugia malayi Niemann-Pick C1 protein precursor 0.0225 0.0212 0.524
Onchocerca volvulus 0.0042 0.0027 0.056
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0024 0.0009 0.0113
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0154 0.0141 0.1505
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0042 0.0027 0.0388
Schistosoma mansoni ferritin 0.0064 0.0049 0.0728
Schistosoma mansoni chromobox protein 0.0145 0.0132 0.1984
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.001 0.2216
Mycobacterium tuberculosis Conserved hypothetical protein 0.0022 0.0007 0.0004
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.001 0.0007
Schistosoma mansoni bromodomain containing protein 0.0065 0.005 0.0742
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0042 0.0027 0.0388
Echinococcus granulosus ecdysone induced protein 78C 0.0042 0.0027 0.0388
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0372 0.0362 0.8968
Loa Loa (eye worm) steroid hormone receptor 0.0042 0.0027 0.0636
Echinococcus granulosus expressed protein 0.0064 0.0049 0.0728
Plasmodium vivax hypothetical protein, conserved 0.0024 0.0009 0.174
Schistosoma mansoni nuclear receptor 0.002 0.0004 0.0049
Schistosoma mansoni tar DNA-binding protein 0.0144 0.013 0.1956
Schistosoma mansoni hypothetical protein 0.0254 0.0243 0.3661
Loa Loa (eye worm) hypothetical protein 0.0037 0.0022 0.0519
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0042 0.0027 0.056
Schistosoma mansoni DNA polymerase eta 0.0022 0.0007 0.0088
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0022 0.0007 0.0144
Trichomonas vaginalis esterase, putative 0.0037 0.0022 0.1232
Echinococcus granulosus FTZ F1 alpha 0.0042 0.0027 0.0388
Echinococcus multilocularis mitogen activated protein kinase 3 0.0051 0.0036 0.0378
Schistosoma mansoni ferritin 0.0064 0.0049 0.0728
Schistosoma mansoni thyroid hormone receptor 0.0042 0.0027 0.0388
Toxoplasma gondii HEAT repeat-containing protein 0.0033 0.0018 0.4553
Brugia malayi Nuclear hormone receptor E75 0.002 0.0004 0.0056
Entamoeba histolytica calcineurin catalytic subunit A, putative 0.0051 0.0036 0.1569
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0007 0.1221
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0096 0.0082 0.2017
Brugia malayi hypothetical protein 0.0022 0.0007 0.0115
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0009 0.0379
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0007 0.1926
Mycobacterium ulcerans bacterioferritin BfrA 0.0064 0.0049 0.0046
Trypanosoma cruzi serine/threonine protein phosphatase 2B catalytic subunit A2, putative 0.0051 0.0036 0.9864
Loa Loa (eye worm) hypothetical protein 0.0024 0.0009 0.0185
Loa Loa (eye worm) hypothetical protein 0.002 0.0004 0.0081
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0042 0.0027 0.0636
Loa Loa (eye worm) hypothetical protein 0.0022 0.0007 0.014
Schistosoma mansoni hypothetical protein 0.0389 0.0379 0.5737
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.001 0.0007
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0064 0.0049 0.0046
Brugia malayi ecdysteroid receptor 0.0042 0.0027 0.0613
Schistosoma mansoni hypothetical protein 0.002 0.0005 0.0053
Trypanosoma brucei unspecified product 0.0022 0.0007 0.1926
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0046 0.0031 0.8438
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0003 0.0001
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0042 0.0027 0.0613
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0022 0.5662
Mycobacterium ulcerans hypothetical protein 0.0037 0.0022 0.0019
Echinococcus multilocularis dna polymerase kappa 0.0022 0.0007 0.0062
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.001 0.2216
Echinococcus granulosus chromobox protein 2 0.0024 0.0009 0.0113
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0012 0.2741
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0009 0.0379
Trichomonas vaginalis conserved hypothetical protein 0.0082 0.0067 0.4253
Loa Loa (eye worm) hypothetical protein 0.0037 0.0022 0.0506
Onchocerca volvulus 0.0037 0.0022 0.0428
Echinococcus granulosus neuropeptide s receptor 0.0447 0.0437 0.6618
Loa Loa (eye worm) hypothetical protein 0.0022 0.0007 0.014
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.001 0.0007
Brugia malayi hypothetical protein 0.006 0.0046 0.1087
Loa Loa (eye worm) hypothetical protein 0.0022 0.0007 0.014
Brugia malayi nuclear receptor NHR-88 0.0042 0.0027 0.0613
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0007 0.1926
Schistosoma mansoni ferritin light chain 0.0064 0.0049 0.0728
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.001 0.2216
Brugia malayi Nuclear hormone receptor E75 0.002 0.0004 0.0056
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0003 0.0019
Schistosoma mansoni hypothetical protein 0.0354 0.0343 0.5187
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0051 0.0036 1
Echinococcus granulosus GPCR family 2 0.0118 0.0104 0.1558
Brugia malayi CHD4 protein 0.0026 0.0011 0.0207
Mycobacterium tuberculosis Conserved protein 0.0037 0.0022 0.0019
Schistosoma mansoni intermediate filament proteins 0.0026 0.0011 0.0147
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0004 0.0035
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0003 0.0018
Brugia malayi Ets-domain containing protein 0.0087 0.0073 0.1769
Schistosoma mansoni zinc finger protein 0.002 0.0004 0.0049
Loa Loa (eye worm) hypothetical protein 0.0026 0.001 0.0229
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0118 0.0104 0.1558
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.002 0.0004 0.0049
Leishmania major importin beta-1 subunit, putative 0.0027 0.0012 0.2648
Loa Loa (eye worm) hypothetical protein 0.0037 0.0022 0.0506
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0064
Echinococcus granulosus nuclear receptor nhr 48 0.002 0.0004 0.0049
Brugia malayi hypothetical protein 0.0042 0.0027 0.0628
Loa Loa (eye worm) hypothetical protein 0.0027 0.0012 0.0267
Brugia malayi PHD-finger family protein 0.0028 0.0013 0.0258
Trypanosoma cruzi DNA polymerase eta, putative 0.0022 0.0007 0.1221
Brugia malayi steroid hormone receptor 0.0042 0.0027 0.0613
Loa Loa (eye worm) hypothetical protein 0.002 0.0004 0.0081
Entamoeba histolytica calcineurin catalytic subunit A, putative 0.0051 0.0036 0.1569
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0026 0.0011 0.01
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0022 0.0019
Entamoeba histolytica hypothetical protein 0.0043 0.0029 0.1224
Leishmania major serine/threonine protein phosphatase 2B catalytic subunit A2, putative 0.0051 0.0036 0.9864
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0022 0.0019
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0022 0.0007 0.0085
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0051 0.0036 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0042 0.0027 0.0388
Schistosoma mansoni hypothetical protein 0.0093 0.0079 0.1177
Entamoeba histolytica hypothetical protein 0.0027 0.0012 0.0421
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.0007 0.0082
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0007 0.1926
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0022 0.0482
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0011 0.0241
Echinococcus granulosus snurportin 1 0.0354 0.0343 0.5187
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0061 0.0047 0.0689
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0061 0.0046 0.1117
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0024 0.0009 0.008
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0043
Schistosoma mansoni chromobox protein 0.0024 0.0009 0.0113
Loa Loa (eye worm) hypothetical protein 0.0051 0.0036 0.086
Entamoeba histolytica calcineurin catalytic subunit A, putative 0.0051 0.0036 0.1569
Entamoeba histolytica acetyltransferase, GNAT family 0.004 0.0025 0.1039
Loa Loa (eye worm) hypothetical protein 0.0025 0.001 0.0226
Loa Loa (eye worm) hypothetical protein 0.0064 0.0049 0.1196
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0029 0.0295
Brugia malayi Associated with TFs and helicases family protein 0.0024 0.0009 0.016
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0012 0.2705
Loa Loa (eye worm) hypothetical protein 0.0022 0.0007 0.014
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.001 0.0007
Schistosoma mansoni retinoic acid receptor RXR 0.0042 0.0027 0.0388
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0022 0.0019
Brugia malayi AMP-binding enzyme family protein 0.0025 0.001 0.0202
Schistosoma mansoni lamin 0.0026 0.0011 0.0147
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0042 0.0027 0.0388
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0004 0.0001
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0007 0.0119
Toxoplasma gondii ABC1 family protein 0.0037 0.0022 0.5585
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0042 0.0027 0.0276
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0009 0.0379
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0007 0.0115
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0042 0.0027 0.0613
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0154 0.0141 0.2119
Loa Loa (eye worm) hypothetical protein 0.0042 0.0027 0.0636
Schistosoma mansoni ran 0.0024 0.0009 0.0122
Trichomonas vaginalis importin beta-1, putative 0.0027 0.0012 0.0584
Trypanosoma cruzi importin beta-1 subunit, putative 0.0027 0.0012 0.2648
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0042 0.0027 0.0276
Brugia malayi Steroid receptor seven-up type 2 0.0042 0.0027 0.0613
Schistosoma mansoni aryl hydrocarbon receptor nuclear translocator homolog (darnt) 0.0043 0.0028 0.0402
Echinococcus granulosus tar DNA binding protein 0.0144 0.013 0.1956
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0042 0.0027 0.0388
Onchocerca volvulus 0.0024 0.0009 0.0105
Schistosoma mansoni gabp alpha 0.0087 0.0073 0.1092
Brugia malayi RNA, U transporter 1 0.0094 0.008 0.194
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0046 0.0031 0.8324
Loa Loa (eye worm) latrophilin receptor protein 2 0.0118 0.0104 0.2554
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0022 0.0007 0.0004
Brugia malayi latrophilin 2 splice variant baaae 0.0254 0.0243 0.5991
Brugia malayi PAS domain containing protein 0.0018 0.0003 0.0018
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0064
Schistosoma mansoni tar DNA-binding protein 0.0144 0.013 0.1956
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0012 0.2741
Trichomonas vaginalis chromobox protein, putative 0.0088 0.0073 0.4669
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0154 0.0141 0.2119
Schistosoma mansoni ets-related 0.0265 0.0254 0.383
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0042 0.0027 0.0636
Plasmodium falciparum heterochromatin protein 1 0.0024 0.0009 0.174
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0004 0.0049
Loa Loa (eye worm) hypothetical protein 0.0033 0.0018 0.042
Brugia malayi chromobox protein homolog 3 0.0082 0.0067 0.162
Loa Loa (eye worm) hypothetical protein 0.0254 0.0243 0.6001
Echinococcus multilocularis protein dispatched 1 0.011 0.0096 0.1022
Mycobacterium leprae Probable lipase LipE 0.0037 0.0022 0.0019
Leishmania major protein kinase, putative 0.0019 0.0003 0.014
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0022 0.0007 0.0061
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0088 0.0073 0.173
Plasmodium vivax hypothetical protein, conserved 0.0024 0.0009 0.174
Trypanosoma brucei protein kinase, putative 0.0051 0.0036 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0042 0.0027 0.0276
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0029 0.0415
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0233 0.0221 0.0218
Plasmodium falciparum serine/threonine protein phosphatase 2B catalytic subunit A 0.0051 0.0036 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0042 0.0027 0.0613
Schistosoma mansoni terminal deoxycytidyl transferase 0.0022 0.0007 0.0088
Schistosoma mansoni tar DNA-binding protein 0.0144 0.013 0.1956
Loa Loa (eye worm) hypothetical protein 0.006 0.0046 0.1109
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.001 0.0007
Loa Loa (eye worm) TAR-binding protein 0.0144 0.013 0.3206
Echinococcus multilocularis neuropeptide s receptor 0.0447 0.0437 0.47
Onchocerca volvulus Huntingtin homolog 0.0413 0.0403 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0118 0.0104 0.2536
Brugia malayi nuclear receptor NHR-88 0.002 0.0004 0.0056
Trichomonas vaginalis ferritin, putative 0.0064 0.0049 0.3063
Onchocerca volvulus Protein ultraspiracle homolog 0.0042 0.0027 0.056
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0018 0.0003 0.0031
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0036 0.2206
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0042 0.0027 0.0388
Loa Loa (eye worm) acetyltransferase 0.0149 0.0136 0.335
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0228 0.0216 0.3257
Brugia malayi Heterochromatin protein 1 0.0145 0.0132 0.3235
Trichomonas vaginalis chromobox protein, putative 0.0024 0.0009 0.0379
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0051 0.0036 0.0871
Trichomonas vaginalis conserved hypothetical protein 0.0096 0.0082 0.5254
Brugia malayi aryl hydrocarbon receptor nuclear translocator protein, putative 0.0043 0.0028 0.0636
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0061 0.0047 0.0489
Brugia malayi SET domain containing protein 0.0024 0.0009 0.016
Brugia malayi beta-lactamase 0.0037 0.0022 0.0482
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0042 0.0027 0.0636
Brugia malayi orphan nuclear receptor NR2E1 0.002 0.0004 0.0056
Schistosoma mansoni nuclear receptor 0.002 0.0004 0.0049
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0354 0.0343 0.8503
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0009 0.0379
Leishmania major serine/threonine protein phosphatase, putative 0.0051 0.0036 0.9864
Echinococcus multilocularis microtubule associated protein 2 0.0667 0.066 0.7102
Entamoeba histolytica hypothetical protein 0.0024 0.0009 0.0273
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0042 0.0027 0.0636
Schistosoma mansoni hypothetical protein 0.0043 0.0029 0.0415
Loa Loa (eye worm) hypothetical protein 0.0042 0.0027 0.0652
Echinococcus granulosus mitogen activated protein kinase 0.0051 0.0036 0.0532
Echinococcus multilocularis Chromo domain 0.0024 0.0009 0.008
Brugia malayi Ets-domain containing protein 0.0087 0.0073 0.1769
Leishmania major protein kinase, putative 0.0019 0.0003 0.014
Schistosoma mansoni ran 0.0024 0.0009 0.0122
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0036 0.2206
Giardia lamblia DINP protein human, muc B family 0.0022 0.0007 0.122
Brugia malayi hypothetical protein 0.0043 0.0029 0.0657
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.002 0.0199
Echinococcus granulosus ferritin 0.0064 0.0049 0.0728
Plasmodium vivax importin-beta 2, putative 0.0033 0.0018 0.4616
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0042 0.0027 0.0613
Loa Loa (eye worm) hypothetical protein 0.0042 0.0027 0.0636
Brugia malayi CHE-14 protein 0.0096 0.0082 0.1996
Brugia malayi aryl hydrocarbon receptor AHR-1 0.0042 0.0027 0.0628
Brugia malayi Calcitonin receptor-like protein seb-1 0.0372 0.0362 0.8968
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0024 0.0009 0.1892
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0007 0.1926
Loa Loa (eye worm) hypothetical protein 0.0037 0.0022 0.0506
Echinococcus granulosus expressed conserved protein 0.0211 0.0199 0.2994
Echinococcus granulosus thyroid hormone receptor alpha 0.002 0.0004 0.0049
Leishmania major DNA polymerase kappa, putative 0.0022 0.0007 0.1221
Mycobacterium ulcerans transcriptional regulator 0.9877 1 1
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0007 0.1926
Leishmania major hypothetical protein, conserved 0.0027 0.0012 0.2705
Echinococcus granulosus intermediate filament protein 0.0026 0.0011 0.0147
Loa Loa (eye worm) hypothetical protein 0.002 0.0004 0.0081
Trypanosoma cruzi serine/threonine protein phosphatase, putative 0.0051 0.0036 0.9864
Brugia malayi Protein cec-1. 0.0024 0.0009 0.016
Brugia malayi RNA recognition motif domain containing protein 0.0144 0.013 0.3189
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0012 0.3291
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0149 0.0136 0.2043
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0009 0.0379
Leishmania major DNA polymerase eta, putative 0.0022 0.0007 0.1221
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0007 0.1221
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0022 0.0019
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0018 0.0003 0.0022
Brugia malayi nuclear receptor NHR-67 0.002 0.0004 0.0056
Brugia malayi Importin beta-1 subunit 0.0033 0.0018 0.0396
Echinococcus granulosus Niemann Pick C1 protein 0.0225 0.0212 0.3204
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0007 0.0004
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0022 0.5586
Echinococcus granulosus lamin 0.0026 0.0011 0.0147
Echinococcus granulosus Niemann Pick C1 protein 0.0321 0.031 0.4687
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0024 0.0009 0.2544
Schistosoma mansoni hypothetical protein 0.0024 0.0009 0.0113
Loa Loa (eye worm) hypothetical protein 0.002 0.0004 0.0081
Toxoplasma gondii protein phosphatase 2B catalytic subunit, calcineurin family phosphatse superfamily protein 0.0051 0.0036 0.9864
Echinococcus granulosus GA binding protein alpha chain 0.0087 0.0073 0.1092
Schistosoma mansoni hypothetical protein 0.0118 0.0104 0.1558
Loa Loa (eye worm) hypothetical protein 0.0096 0.0082 0.2017
Schistosoma mansoni hypothetical protein 0.0118 0.0104 0.1558
Plasmodium falciparum importin beta, putative 0.0033 0.0018 0.4616
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0042 0.0027 0.0613
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0042 0.0027 0.0276
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0022 0.1232
Loa Loa (eye worm) hypothetical protein 0.002 0.0004 0.0081
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0022 0.0019
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0018 0.4991
Echinococcus multilocularis dna polymerase eta 0.0022 0.0007 0.0062
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.002 0.0281
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0042 0.0027 0.0388
Trichomonas vaginalis bromodomain-containing protein, putative 0.0046 0.0031 0.1836
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0009 0.0379
Entamoeba histolytica hypothetical protein 0.0024 0.0009 0.0273
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0007 0.0085
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0051 0.0036 1
Schistosoma mansoni zinc finger protein 0.0023 0.0007 0.0093
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0022 0.0007 0.0088
Loa Loa (eye worm) DR-78 0.002 0.0004 0.0081
Trichomonas vaginalis Heterochromatin protein, putative 0.0024 0.0009 0.0379
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0007 0.1926
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0009 0.0379
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0022 0.0219
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0022 0.0019
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0007 0.1221
Echinococcus multilocularis FTZ F1 alpha 0.0042 0.0027 0.0276
Brugia malayi Bromodomain containing protein 0.0041 0.0026 0.0585
Schistosoma mansoni hypothetical protein 0.0118 0.0104 0.1558
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0007 0.0119
Schistosoma mansoni hypothetical protein 0.0093 0.0079 0.1177
Loa Loa (eye worm) hypothetical protein 0.0225 0.0212 0.5252
Schistosoma mansoni thyroid hormone receptor 0.0042 0.0027 0.0388
Onchocerca volvulus Huntingtin homolog 0.0413 0.0403 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0009 0.0379
Brugia malayi AMP-binding enzyme family protein 0.0025 0.001 0.0202
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0024 0.0009 0.174
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0042 0.0027 0.0636
Echinococcus granulosus geminin 0.0389 0.0379 0.5737
Echinococcus granulosus sterol regulatory element binding protein 0.0096 0.0082 0.123
Brugia malayi hypothetical protein 0.0043 0.0028 0.0636
Brugia malayi hypothetical protein 0.0413 0.0403 1
Echinococcus multilocularis serine:threonine protein phosphatase 2B 0.0051 0.0036 0.0373
Mycobacterium ulcerans beta-lactamase 0.0037 0.0022 0.0019
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0046 0.0031 0.8324
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0019 0.0003 0.014
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0024 0.0009 0.1892
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0042 0.0027 0.0613
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0026 0.0011 0.0141
Schistosoma mansoni nuclear hormone receptor 0.002 0.0004 0.0049
Loa Loa (eye worm) nuclear receptor NHR-67 0.002 0.0004 0.0081
Loa Loa (eye worm) hypothetical protein 0.0026 0.0011 0.0241
Mycobacterium ulcerans AcrR family transcriptional regulator 0.9877 1 1
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0172 0.0159 0.3903
Schistosoma mansoni nuclear receptor nhr-48 0.002 0.0004 0.0049
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0022 0.0019
Onchocerca volvulus 0.0024 0.0009 0.0105
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0011 0.0217
Loa Loa (eye worm) hypothetical protein 0.002 0.0004 0.0081
Echinococcus multilocularis chromobox protein 1 0.0145 0.0132 0.1409
Brugia malayi nuclear hormone receptor 0.0042 0.0027 0.0613
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0042 0.0027 0.0388
Echinococcus granulosus histone acetyltransferase KAT2B 0.0143 0.0129 0.1945
Loa Loa (eye worm) CHromoDomain protein family member 0.0026 0.0011 0.0231
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0024 0.0009 0.02
Mycobacterium tuberculosis Conserved protein 0.0037 0.0022 0.0019
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0064 0.0049 0.0046
Brugia malayi Serine/threonine protein phosphatase 2B catalytic subunit 2 0.0051 0.0036 0.0837
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0022 0.0019
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0036 0.2206
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0024 0.0009 0.0113
Echinococcus granulosus histone acetyltransferase KAT2B 0.0046 0.0031 0.0447
Echinococcus multilocularis expressed protein 0.0064 0.0049 0.0517
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0022 0.0007 0.0085
Brugia malayi conserved hypotetical protein 0.002 0.0004 0.0056
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.001 0.0007
Brugia malayi nuclear receptor RXR 0.0022 0.0007 0.0115
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0024 0.0009 0.0086
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0003 0.0026
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0022 0.0007 0.0269
Echinococcus multilocularis snurportin 1 0.0354 0.0343 0.3684
Loa Loa (eye worm) hypothetical protein 0.0042 0.0027 0.0636
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0022 0.5586
Trichomonas vaginalis conserved hypothetical protein 0.0167 0.0154 1
Echinococcus granulosus Chromobox protein 3 0.0024 0.0009 0.0113
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0012 0.2704
Loa Loa (eye worm) hypothetical protein 0.0024 0.0009 0.0185
Schistosoma mansoni apoferritin-2 0.0064 0.0049 0.0728
Loa Loa (eye worm) hypothetical protein 0.002 0.0004 0.0081
Loa Loa (eye worm) hypothetical protein 0.002 0.0004 0.0081
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0372 0.0362 0.8971
Schistosoma mansoni chromobox protein 0.0145 0.0132 0.1984
Schistosoma mansoni steroid hormone receptor ad4bp 0.0042 0.0027 0.0388
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0042 0.0027 0.0613
Brugia malayi hypothetical protein 0.002 0.0004 0.0056
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0009 0.0273
Trypanosoma cruzi serine/threonine protein phosphatase, putative 0.0051 0.0036 0.9864
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0009 0.0379
Brugia malayi hypothetical protein 0.0024 0.0009 0.016
Loa Loa (eye worm) hypothetical protein 0.0413 0.0403 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0003 0.0001
Loa Loa (eye worm) hypothetical protein 0.002 0.0004 0.0081
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0042 0.0027 0.0388
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.001 0.0007
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0009 0.1893
Entamoeba histolytica deoxycytidyl transferase, putative 0.0022 0.0007 0.0194
Mycobacterium ulcerans lipase LipD 0.0037 0.0022 0.0019
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.0007 0.0082
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0022 0.1232
Brugia malayi photoreceptor-specific nuclear receptor 0.0042 0.0027 0.0613
Echinococcus multilocularis tumor protein p63 0.0388 0.0378 0.4061
Echinococcus multilocularis protein patched 0.0096 0.0082 0.0874
Echinococcus granulosus chromobox protein 1 0.0145 0.0132 0.1984
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.001 0.0008
Loa Loa (eye worm) hypothetical protein 0.0372 0.0362 0.8971
Loa Loa (eye worm) hypothetical protein 0.0057 0.0042 0.1018
Trypanosoma brucei DNA polymerase eta, putative 0.0022 0.0007 0.1926
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0019 0.0003 0.014
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0024 0.0009 0.1716
Brugia malayi beta-lactamase family protein 0.0037 0.0022 0.0482
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0154 0.0141 0.3473
Echinococcus granulosus importin subunit beta 1 0.0033 0.0018 0.0256
Echinococcus multilocularis GPCR, family 2 0.0118 0.0104 0.1107
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0042 0.0027 0.0276
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0022 0.0506
Schistosoma mansoni patched 1 0.0096 0.0082 0.123
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0022 0.1232
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0154 0.0141 0.2119
Brugia malayi ecdysone receptor 0.002 0.0004 0.0056
Onchocerca volvulus 0.0026 0.0011 0.0162
Loa Loa (eye worm) hypothetical protein 0.0022 0.0007 0.0144
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0024 0.0009 0.1918
Onchocerca volvulus 0.0025 0.001 0.0147
Brugia malayi Fli-1 protein 0.0265 0.0254 0.627
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.002 0.0004 0.0056
Echinococcus granulosus lamin dm0 0.0026 0.0011 0.0147
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0005 0.0087
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0007 0.0115
Schistosoma mansoni microtubule-associated protein tau 0.0667 0.066 1
Onchocerca volvulus 0.0024 0.0009 0.0105
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.001 0.0352
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0046 0.0031 0.1836
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR 0.9877 1 1
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0087 0.0073 0.179
Onchocerca volvulus 0.006 0.0046 0.1037
Schistosoma mansoni importin beta-1 0.0033 0.0018 0.0256
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0009 0.0379
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0009 0.0379
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.002 0.0004 0.0049
Echinococcus multilocularis musashi 0.0026 0.0011 0.0105
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0022 0.594
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0009 0.0379
Onchocerca volvulus Bile acid receptor homolog 0.0042 0.0027 0.056
Schistosoma mansoni ferritin 0.0064 0.0049 0.0728
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0154 0.0141 0.2119
Onchocerca volvulus 0.0064 0.0049 0.1125
Brugia malayi acetyltransferase, GNAT family protein 0.0149 0.0136 0.3333
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0007 0.1221
Echinococcus multilocularis aryl hydrocarbon receptor 0.0061 0.0046 0.0484
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0009 0.0379
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.001 0.0352
Loa Loa (eye worm) hypothetical protein 0.0413 0.0403 1
Brugia malayi nuclear hormone receptor family member nhr-6 0.002 0.0004 0.0056
Mycobacterium ulcerans bacterioferritin BfrB 0.0064 0.0049 0.0046
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0009 0.0379
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0009 0.0379
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0009 0.0379
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0064
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0003 0.0043
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0009 0.1893
Loa Loa (eye worm) hypothetical protein 0.0024 0.0009 0.0185
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0042 0.0027 0.0636
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0932 0.093 1
Mycobacterium ulcerans hypothetical protein 0.0025 0.001 0.0007
Loa Loa (eye worm) RNA binding protein 0.0144 0.013 0.3206
Brugia malayi AMP-binding enzyme family protein 0.0025 0.001 0.0202
Echinococcus granulosus dna polymerase kappa 0.0022 0.0007 0.0088
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0022 0.0019
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0012 0.2741
Loa Loa (eye worm) nuclear receptor nhr-7B 0.002 0.0004 0.0081
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0043 0.0028 0.0659
Brugia malayi tailless protein 0.002 0.0004 0.0056
Loa Loa (eye worm) hypothetical protein 0.0042 0.0027 0.0652
Loa Loa (eye worm) MH2 domain-containing protein 0.0115 0.0101 0.2492
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0007 0.1926
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0043 0.2655
Echinococcus multilocularis tar DNA binding protein 0.0144 0.013 0.1389
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0042 0.0027 0.0613
Echinococcus multilocularis Nuclear hormone receptor HR96 0.002 0.0004 0.0035
Echinococcus multilocularis GA binding protein alpha chain 0.0087 0.0073 0.0775
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0003 0.0804
Loa Loa (eye worm) hypothetical protein 0.0042 0.0027 0.0652
Echinococcus multilocularis sterol regulatory element binding protein 0.0096 0.0082 0.0874
Trichomonas vaginalis hypothetical protein 0.0024 0.0009 0.0379
Entamoeba histolytica hypothetical protein 0.0043 0.0029 0.1224
Echinococcus multilocularis nuclear receptor nhr 48 0.002 0.0004 0.0035
Entamoeba histolytica hypothetical protein 0.0043 0.0029 0.1224
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0036 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0042 0.0027 0.0613
Schistosoma mansoni apoferritin-2 0.0064 0.0049 0.0728
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0051 0.0036 1
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0007 0.1926
Schistosoma mansoni cellular tumor antigen P53 0.0057 0.0042 0.0621
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.001 0.0007
Treponema pallidum bacterioferrin (TpF1) 0.0064 0.0049 1
Schistosoma mansoni tar DNA-binding protein 0.0144 0.013 0.1956
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.0004 0.0261
Brugia malayi Nuclear hormone receptor-like 1 0.0042 0.0027 0.0613
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0042 0.0027 0.0636
Schistosoma mansoni hypothetical protein 0.0093 0.0079 0.1177
Loa Loa (eye worm) hypothetical protein 0.0042 0.0027 0.0636
Loa Loa (eye worm) hypothetical protein 0.0037 0.0022 0.0506
Plasmodium vivax serine/threonine protein phosphatase 2B catalytic subunit A, putative 0.0051 0.0036 1
Schistosoma mansoni hypothetical protein 0.0093 0.0079 0.1177
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0225 0.0212 1
Schistosoma mansoni tar DNA-binding protein 0.0144 0.013 0.1956
Echinococcus granulosus tumor protein p63 0.0388 0.0378 0.5719
Brugia malayi RNA binding protein 0.0144 0.013 0.3189
Loa Loa (eye worm) hypothetical protein 0.0042 0.0027 0.0636
Echinococcus multilocularis chromobox protein 1 0.0145 0.0132 0.1409
Brugia malayi TAR-binding protein 0.0144 0.013 0.3189
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0022 0.0308
Schistosoma mansoni coup transcription factor 0.0042 0.0027 0.0388
Onchocerca volvulus 0.0037 0.0022 0.0428
Echinococcus granulosus neuropeptide receptor A26 0.0447 0.0437 0.6618

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) = 8.991 uM PUBCHEM_BIOASSAY: Reversing Antifungal Drug Resistance Measured in Microorganism System Using Plate Reader - 2037-01_Inhibitor_Dose_DryPowder_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2007] ChEMBL. No reference
AC50 (functional) = 23.01 uM PUBCHEM_BIOASSAY: Antifungal Drug Resistance - Resistant Strain Measured in Microorganism System Using Plate Reader - 2037-02_Inhibitor_Dose_DryPowder_Activity_Set4. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2007] ChEMBL. No reference
Potency (functional) 3.1623 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.6964 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 4.6535 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 10.3225 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 17.7828 uM PubChem BioAssay. qHTS for Small Molecule Inhibitors of the ERG Ets/DNA interaction. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.5878 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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