TDR Targets

Basic information

Technical information

TDR Targets ID: 1307947
Name: STK041298
MW: 311.332 | Formula: C18H17NO4
H donors: 1 H acceptors: 3 LogP: 0.88 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: OC(=O)C1C2C=CC3(C1C(=O)N(C3)C/C=C/c1ccccc1)O2
InChi: 1S/C18H17NO4/c20-16-15-14(17(21)22)13-8-9-18(15,23-13)11-19(16)10-4-7-12-5-2-1-3-6-12/h1-9,13-15H,10-11H2,(H,21,22)/b7-4+
InChiKey: NNUJCNWGCDEOES-QPJJXVBHSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

IDI1_007178
Enamine_003535
Oprea1_137861
BAS 03163057
Oprea1_224342
MLS000111509
SMR000107431

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	polymerase (DNA directed), beta	Starlite/ChEMBL	No references
Homo sapiens	APEX nuclease (multifunctional DNA repair enzyme) 1	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Leishmania infantum	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium berghei	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	Get druggable targets OG5_130965	All targets in OG5_130965
Leishmania infantum	mitochondrial DNA polymerase beta	Get druggable targets OG5_130965	All targets in OG5_130965
Schistosoma mansoni	ap endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma brucei	mitochondrial DNA polymerase beta	Get druggable targets OG5_130965	All targets in OG5_130965
Plasmodium yoelii	putative AP endonuclease-related	Get druggable targets OG5_126768	All targets in OG5_126768
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	ko:K10771 AP endonuclease 1, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma mansoni	ap endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	ko:K10772 AP endonuclease 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Treponema pallidum	exodeoxyribonuclease (exoA)	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma congolense	mitochondrial DNA polymerase beta, putative	Get druggable targets OG5_130965	All targets in OG5_130965
Leishmania braziliensis	mitochondrial DNA polymerase beta	Get druggable targets OG5_130965	All targets in OG5_130965
Leishmania mexicana	apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	Get druggable targets OG5_126768	All targets in OG5_126768
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Candida albicans	similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Entamoeba histolytica	exodeoxyribonuclease III, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma congolense	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Toxoplasma gondii	exonuclease III APE	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma brucei gambiense	mitochondrial DNA polymerase beta	Get druggable targets OG5_130965	All targets in OG5_130965
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Trichomonas vaginalis	ap endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Candida albicans	similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania braziliensis	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania major	mitochondrial DNA polymerase beta	Get druggable targets OG5_130965	All targets in OG5_130965
Leishmania donovani	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	Get druggable targets OG5_130965	All targets in OG5_130965
Mycobacterium ulcerans	hypothetical protein	Get druggable targets OG5_130965	All targets in OG5_130965
Theileria parva	hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Brugia malayi	exodeoxyribonuclease III family protein	Get druggable targets OG5_126768	All targets in OG5_126768
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	Get druggable targets OG5_126768	All targets in OG5_126768
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	DNA-(apurinic or apyrimidinic site) lyase 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	DNA-(apurinic or apyrimidinic site) lyase 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Mycobacterium tuberculosis	Conserved hypothetical protein	Get druggable targets OG5_130965	All targets in OG5_130965
Trypanosoma brucei gambiense	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi	exonuclease III	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania mexicana	mitochondrial DNA polymerase beta	Get druggable targets OG5_130965	All targets in OG5_130965
Trichomonas vaginalis	ap endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania donovani	mitochondrial DNA polymerase beta	Get druggable targets OG5_130965	All targets in OG5_130965
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Cryptosporidium parvum	conserved hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768
Cryptosporidium hominis	dna-(apurinic or apyrimidinic site) lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Neospora caninum	hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium knowlesi	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	polymerase (DNA directed), beta	335 aa	303 aa	32.3 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	diacylglycerol kinase, putative	0.0071	0.0316	0.0269
Schistosoma mansoni	tubulin subunit delta	0.0054	0.0221	0.022
Trichomonas vaginalis	tubulin alpha chain, putative	0.007	0.0311	0.2596
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0053	0.0218	0.0217
Plasmodium vivax	tubulin alpha chain, putative	0.0231	0.1197	1
Echinococcus multilocularis	GPCR, family 2	0.0017	0.0017	0.0016
Trypanosoma cruzi	diacylglycerol kinase-like protein, putative	0.0071	0.0316	0.1632
Brugia malayi	CXXC zinc finger family protein	0.0022	0.0046	0.0344
Mycobacterium tuberculosis	Probable reductase	0.0092	0.0432	0.0431
Echinococcus granulosus	ceramide kinase	0.0071	0.0316	0.0315
Loa Loa (eye worm)	tubulin alpha-3 chain	0.0161	0.0809	0.0809
Toxoplasma gondii	beta-tubulin, putative	0.0124	0.0609	0.5084
Echinococcus multilocularis	beta tubulin	0.0124	0.0609	0.0608
Trypanosoma cruzi	diacylglycerol kinase, putative	0.0071	0.0316	0.1632
Echinococcus multilocularis	tubulin alpha 3 chain	0.0231	0.1197	0.1196
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0049	0.0192	0.0191
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0103	0.0489	0.0488
Echinococcus granulosus	tubulin alpha 3 chain	0.0231	0.1197	0.1196
Entamoeba histolytica	tubulin alpha chain, putative	0.0231	0.1197	0.1153
Echinococcus granulosus	GPCR family 2	0.0017	0.0017	0.0016
Giardia lamblia	Beta tubulin	0.0124	0.0609	0.5084
Brugia malayi	Tubulin alpha chain	0.0231	0.1197	0.9206
Trichomonas vaginalis	tubulin, putative	0.007	0.0311	0.2596
Trypanosoma brucei	alpha tubulin	0.0231	0.1197	0.6189
Loa Loa (eye worm)	hypothetical protein	0.1829	1	1
Trichomonas vaginalis	tubulin gamma chain, putative	0.0054	0.0221	0.1842
Trypanosoma cruzi	cytochrome P450, putative	0.0021	0.0038	0.0191
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0092	0.0432	0.788
Echinococcus multilocularis	tubulin alpha chain	0.0231	0.1197	0.1196
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0053	0.0217	0.1666
Loa Loa (eye worm)	tubulin alpha-2 chain	0.0231	0.1197	0.1197
Toxoplasma gondii	diacylglycerol kinase catalytic domain-containing protein	0.0071	0.0316	0.2637
Loa Loa (eye worm)	cytochrome P450 family protein	0.0052	0.0211	0.0211
Trypanosoma brucei	Diacylglycerol kinase catalytic domain containing protein, putative	0.0071	0.0316	0.1632
Trichomonas vaginalis	tubulin beta chain, putative	0.0124	0.0609	0.5084
Schistosoma mansoni	tubulin subunit epsilon	0.0124	0.0609	0.0608
Brugia malayi	glutathione reductase	0.004	0.0147	0.1121
Leishmania major	sphingosine kinase A, B, putative	0.0071	0.0316	0.1632
Schistosoma mansoni	hypothetical protein	0.0181	0.0922	0.0921
Echinococcus granulosus	intermediate filament protein	0.003	0.0088	0.0087
Trichomonas vaginalis	sphingosine kinase, putative	0.0071	0.0316	0.2637
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0092	0.0432	0.0431
Leishmania major	beta tubulin	0.0124	0.0609	0.3147
Trichomonas vaginalis	tubulin gamma chain, putative	0.0124	0.0609	0.5084
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0017	0.0017	0.0121
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0023	0.0049	0.0248
Schistosoma mansoni	tar DNA-binding protein	0.0068	0.0297	0.0296
Leishmania major	alpha tubulin	0.0231	0.1197	0.6189
Leishmania major	beta tubulin	0.0124	0.0609	0.3147
Leishmania major	hypothetical protein, conserved	0.0071	0.0316	0.1632
Schistosoma mansoni	tyrosine kinase	0.009	0.0419	0.0418
Echinococcus multilocularis	survival motor neuron protein 1	0.025	0.13	0.1299
Echinococcus multilocularis	tubulin alpha chain	0.0231	0.1197	0.1196
Schistosoma mansoni	hypothetical protein	0.0181	0.0922	0.0921
Echinococcus granulosus	tubulin alpha chain	0.0231	0.1197	0.1196
Brugia malayi	tubulin alpha-2 chain	0.0231	0.1197	0.9206
Trypanosoma brucei	epsilon tubulin	0.0124	0.0609	0.3147
Loa Loa (eye worm)	hypothetical protein	0.0231	0.1197	0.1197
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0173	0.0875	0.4522
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0103	0.0489	1
Echinococcus granulosus	beta tubulin	0.0124	0.0609	0.0608
Echinococcus granulosus	peroxisome assembly protein 26	0.0231	0.1197	0.1196
Leishmania major	beta tubulin	0.0124	0.0609	0.3147
Echinococcus granulosus	tubulin beta 1 chain	0.0124	0.0609	0.0608
Toxoplasma gondii	hypothetical protein	0.0059	0.0248	0.2064
Onchocerca volvulus	Ceramide kinase 1 homolog	0.0071	0.0316	1
Loa Loa (eye worm)	alpha-tubulin isotype 2	0.0177	0.0899	0.0899
Trypanosoma cruzi	tubulin delta chain	0.0054	0.0221	0.114
Echinococcus granulosus	insulin receptor	0.0053	0.0218	0.0217
Plasmodium falciparum	alpha tubulin 2	0.0231	0.1197	1
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0231	0.1197	1
Echinococcus granulosus	tubulin subunit TubB	0.0231	0.1197	0.1196
Echinococcus multilocularis	Tubulin beta 2C chain	0.0124	0.0609	0.0608
Schistosoma mansoni	tyrosine kinase	0.0053	0.0218	0.0217
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0049	0.0192	0.0191
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0014	0.0003	0.0002
Echinococcus granulosus	survival motor neuron protein 1	0.025	0.13	0.1299
Plasmodium falciparum	tubulin epsilon chain, putative	0.0124	0.0609	0.5084
Leishmania major	epsilon tubulin, putative	0.0124	0.0609	0.3147
Brugia malayi	Tubulin alpha chain	0.0054	0.0221	0.1696
Echinococcus multilocularis	tubulin alpha	0.0124	0.0609	0.0608
Loa Loa (eye worm)	tubulin beta-4 chain	0.0124	0.0609	0.0609
Trypanosoma brucei	cytochrome P450, putative	0.0021	0.0038	0.0191
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0049	0.0192	0.1468
Schistosoma mansoni	tubulin subunit beta	0.0124	0.0609	0.0608
Schistosoma mansoni	sphingoid long chain base kinase	0.1829	1	1
Giardia lamblia	Alpha-tubulin	0.0231	0.1197	1
Schistosoma mansoni	tubulin subunit beta	0.0124	0.0609	0.0608
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0177	0.0899	0.7512
Echinococcus granulosus	Tubulin beta 2C chain	0.0124	0.0609	0.0608
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.007	0.0311	0.2596
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.004	0.0147	0.0146
Echinococcus multilocularis	tubulin gamma 1 chain	0.0124	0.0609	0.0608
Loa Loa (eye worm)	tubulin alpha chain	0.0231	0.1197	0.1197
Echinococcus granulosus	Tubulin alpha 1 chain	0.0231	0.1197	0.1196
Leishmania major	alpha tubulin	0.0231	0.1197	0.6189
Echinococcus granulosus	lamin dm0	0.003	0.0088	0.0087
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0049	0.0192	0.0191
Echinococcus multilocularis	peroxisome assembly protein 26	0.0231	0.1197	0.1196
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0316	0.0316
Trypanosoma brucei	tubulin delta chain	0.0054	0.0221	0.114
Trichomonas vaginalis	conserved hypothetical protein	0.0054	0.0221	0.1842
Loa Loa (eye worm)	alpha-tubulin	0.0231	0.1197	0.1197
Loa Loa (eye worm)	tubulin gamma chain	0.0124	0.0609	0.0609
Echinococcus multilocularis	tubulin alpha chain	0.0231	0.1197	0.1196
Trypanosoma brucei	beta tubulin	0.0124	0.0609	0.3147
Leishmania major	delta tubulin, putative	0.0054	0.0221	0.114
Leishmania major	beta tubulin	0.0124	0.0609	0.3147
Echinococcus granulosus	acylglycerol kinase mitochondrial	0.0071	0.0316	0.0315
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0023	0.0049	0.0049
Loa Loa (eye worm)	RNA binding protein	0.0068	0.0297	0.0297
Trypanosoma brucei	diacylglycerol kinase, putative	0.0071	0.0316	0.1632
Echinococcus granulosus	tubulin alpha 1C chain	0.0231	0.1197	0.1196
Brugia malayi	Tubulin beta chain	0.0054	0.0221	0.1696
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0231	0.1197	1
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0042	0.0155	0.1285
Leishmania major	beta tubulin	0.0124	0.0609	0.3147
Echinococcus multilocularis	Diacylglycerol kinase zeta	0.0071	0.0316	0.0315
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0173	0.0875	0.4522
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0003	0.0003
Trypanosoma cruzi	diacylglycerol kinase-like protein, putative	0.0071	0.0316	0.1632
Schistosoma mansoni	alpha tubulin	0.0231	0.1197	0.1196
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0192	0.0982	0.0981
Toxoplasma gondii	alpha-tubulin I, putative	0.0231	0.1197	1
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0023	0.0049	0.0248
Onchocerca volvulus		0.0071	0.0316	1
Echinococcus multilocularis	tubulin alpha 1C chain	0.0231	0.1197	0.1196
Trypanosoma brucei	Sphingosine kinase	0.0071	0.0316	0.1632
Schistosoma mansoni	hypothetical protein	0.0017	0.0017	0.0016
Trypanosoma brucei	alpha tubulin, putative	0.007	0.0311	0.1607
Loa Loa (eye worm)	thioredoxin reductase	0.004	0.0147	0.0147
Echinococcus multilocularis	insulin receptor	0.0053	0.0218	0.0217
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0051	0.0206	0.1063
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0054	0.0221	0.1842
Trypanosoma cruzi	tubulin delta chain	0.0054	0.0221	0.114
Plasmodium vivax	glutathione reductase, putative	0.004	0.0147	0.1218
Schistosoma mansoni	diacylglycerol kinase zeta iota	0.0071	0.0316	0.0315
Schistosoma mansoni	tubulin subunit beta	0.0124	0.0609	0.0608
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0014	0.0001	0.5
Echinococcus granulosus	tubulin alpha chain	0.0231	0.1197	0.1196
Loa Loa (eye worm)	BEN-1 protein	0.0124	0.0609	0.0609
Trichomonas vaginalis	diacylglycerol kinase, epsilon, putative	0.0071	0.0316	0.2637
Echinococcus granulosus	tubulin alpha	0.0124	0.0609	0.0608
Echinococcus granulosus	tubulin alpha 3 chain	0.0231	0.1197	0.1196
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0023	0.0049	0.0048
Mycobacterium tuberculosis	Conserved protein	0.1829	1	1
Brugia malayi	Ceramide kinase	0.0071	0.0316	0.2427
Trypanosoma brucei	beta tubulin	0.0124	0.0609	0.3147
Leishmania major	hypothetical protein, conserved	0.0071	0.0316	0.1632
Schistosoma mansoni	survival motor neuron protein	0.0051	0.0204	0.0203
Echinococcus granulosus	tubulin subunit beta	0.0124	0.0609	0.0608
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.003	0.0088	0.0088
Echinococcus granulosus	epidermal growth factor receptor	0.009	0.0419	0.0418
Schistosoma mansoni	diacylglycerol kinase theta	0.0071	0.0316	0.0315
Trypanosoma cruzi	alpha tubulin, putative	0.0231	0.1197	0.6189
Schistosoma mansoni	hypothetical protein	0.0315	0.1659	0.1658
Trypanosoma brucei	epsilon tubulin	0.0124	0.0609	0.3147
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0041	0.015	0.0149
Echinococcus granulosus	tar DNA binding protein	0.0068	0.0297	0.0296
Leishmania major	alpha tubulin	0.0231	0.1197	0.6189
Mycobacterium tuberculosis	Probable dehydrogenase	0.0092	0.0432	0.0431
Echinococcus granulosus	tubulin gamma 1 chain	0.0124	0.0609	0.0608
Trichomonas vaginalis	tubulin, putative	0.007	0.0311	0.2596
Loa Loa (eye worm)	CYP4Cod1	0.0021	0.0038	0.0038
Brugia malayi	latrophilin 2 splice variant baaae	0.0036	0.0124	0.0951
Brugia malayi	Thioredoxin reductase	0.004	0.0147	0.1121
Schistosoma mansoni	tar DNA-binding protein	0.0068	0.0297	0.0296
Toxoplasma gondii	diacylglycerol kinase accessory domain (presumed) domain-containing protein	0.0071	0.0316	0.2637
Loa Loa (eye worm)	TK/INSR protein kinase	0.0053	0.0218	0.0218
Plasmodium falciparum	diacylglycerol kinase, putative	0.0071	0.0316	0.2637
Schistosoma mansoni	ap endonuclease	0.0023	0.0049	0.0048
Plasmodium falciparum	glutathione reductase	0.004	0.0147	0.1218
Leishmania major	beta tubulin	0.0124	0.0609	0.3147
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0124	0.0609	0.5084
Leishmania major	beta tubulin	0.0124	0.0609	0.3147
Echinococcus granulosus	geminin	0.0181	0.0922	0.0921
Schistosoma mansoni	ap endonuclease	0.0023	0.0049	0.0048
Trichomonas vaginalis	tubulin beta-1 chain, putative	0.0054	0.0221	0.1842
Brugia malayi	Cytochrome P450 family protein	0.0052	0.0211	0.1617
Onchocerca volvulus		0.0051	0.0204	0.5869
Echinococcus multilocularis	acylglycerol kinase, mitochondrial	0.0071	0.0316	0.0315
Brugia malayi	TAR-binding protein	0.0068	0.0297	0.2278
Echinococcus multilocularis	lamin	0.003	0.0088	0.0087
Brugia malayi	Diacylglycerol kinase protein 2	0.0071	0.0316	0.2427
Loa Loa (eye worm)	tubulin beta-2A chain	0.0124	0.0609	0.0609
Trichomonas vaginalis	tubulin alpha chain, putative	0.007	0.0311	0.2596
Plasmodium vivax	tubulin gamma chain, putative	0.0124	0.0609	0.5084
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0017	0.0017
Echinococcus multilocularis	cpg binding protein	0.0023	0.0053	0.0052
Trypanosoma brucei	beta tubulin	0.0124	0.0609	0.3147
Trypanosoma brucei	alpha tubulin	0.0231	0.1197	0.6189
Trypanosoma cruzi	beta tubulin, putative	0.0124	0.0609	0.3147
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0016	0.0012	0.0012
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0051	0.0206	0.1063
Giardia lamblia	Gamma tubulin	0.0124	0.0609	0.5084
Leishmania major	diacylglycerol kinase, putative	0.0071	0.0316	0.1632
Entamoeba histolytica	tubulin alpha-1 chain	0.0231	0.1197	0.1153
Schistosoma mansoni	lamin	0.003	0.0088	0.0087
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0049	0.0192	0.0191
Schistosoma mansoni	tubulin subunit alpha	0.0231	0.1197	0.1196
Echinococcus granulosus	Diacylglycerol kinase theta	0.0071	0.0316	0.0315
Loa Loa (eye worm)	TAR-binding protein	0.0068	0.0297	0.0297
Trypanosoma cruzi	zeta tubulin, putative	0.0054	0.0221	0.114
Leishmania major	mitochondrial DNA polymerase beta	0.0365	0.1933	1
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0023	0.0049	0.0401
Toxoplasma gondii	diacylglycerol kinase, putative	0.0071	0.0316	0.2637
Entamoeba histolytica	tubulin family protein	0.0124	0.0609	0.0563
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0017	0.0017	0.0016
Trypanosoma brucei	hypothetical protein, conserved	0.0071	0.0316	0.1632
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0023	0.0049	0.0401
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0053	0.0218	0.0217
Leishmania major	beta tubulin	0.0124	0.0609	0.3147
Mycobacterium ulcerans	cell division protein FtsZ	0.0054	0.0221	0.022
Schistosoma mansoni	tubulin subunit alpha	0.0054	0.0221	0.022
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0365	0.1933	1
Brugia malayi	Tubulin beta chain	0.007	0.0311	0.239
Schistosoma mansoni	cpg binding protein	0.0023	0.0053	0.0052
Brugia malayi	cytoplasmic intermediate filament protein	0.0016	0.0012	0.0083
Echinococcus granulosus	dnaJ subfamily B	0.0315	0.1659	0.1658
Schistosoma mansoni	hypothetical protein	0.0071	0.0316	0.0315
Entamoeba histolytica	tubulin gamma chain	0.0124	0.0609	0.0563
Trichomonas vaginalis	diacylglycerol kinase, zeta, iota, putative	0.0071	0.0316	0.2637
Loa Loa (eye worm)	hypothetical protein	0.0161	0.0809	0.0809
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0023	0.0049	0.0248
Echinococcus multilocularis	Tubulin beta 2C chain	0.0124	0.0609	0.0608
Echinococcus granulosus	epidermal growth factor receptor	0.0167	0.0845	0.0844
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0023	0.0049	0.0048
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0054	0.0221	0.1842
Leishmania major	beta tubulin	0.0124	0.0609	0.3147
Leishmania major	zeta tubulin, putative	0.0054	0.0221	0.114
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0051	0.0206	0.1063
Leishmania major	alpha tubulin	0.0231	0.1197	0.6189
Plasmodium vivax	thioredoxin reductase, putative	0.004	0.0147	0.1218
Trypanosoma cruzi	hypothetical protein, conserved	0.0071	0.0316	0.1632
Schistosoma mansoni	tar DNA-binding protein	0.0068	0.0297	0.0296
Plasmodium falciparum	thioredoxin reductase	0.004	0.0147	0.1218
Loa Loa (eye worm)	eye-specific diacylglycerol kinase	0.0071	0.0316	0.0316
Schistosoma mansoni	lamin	0.003	0.0088	0.0087
Leishmania major	alpha tubulin	0.0231	0.1197	0.6189
Leishmania major	beta tubulin	0.0124	0.0609	0.3147
Brugia malayi	hypothetical protein	0.025	0.13	1
Leishmania major	gamma-tubulin	0.0124	0.0609	0.3147
Echinococcus multilocularis	tar DNA binding protein	0.0068	0.0297	0.0296
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0017	0.0017	0.0016
Leishmania major	alpha tubulin	0.0231	0.1197	0.6189
Trichomonas vaginalis	tubulin gamma chain, putative	0.0124	0.0609	0.5084
Plasmodium vivax	delta tubulin, putative	0.0054	0.0221	0.1842
Echinococcus granulosus	tubulin alpha 1C chain	0.0231	0.1197	0.1196
Schistosoma mansoni	tubulin subunit beta	0.0124	0.0609	0.0608
Echinococcus granulosus	Tubulin beta 2C chain	0.0124	0.0609	0.0608
Echinococcus multilocularis	dnaJ subfamily B	0.0315	0.1659	0.1658
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0316	0.0316
Echinococcus granulosus	cpg binding protein	0.0023	0.0053	0.0052
Loa Loa (eye worm)	alpha-tubulin	0.0231	0.1197	0.1197
Echinococcus granulosus	Tubulin alpha 1 chain	0.0231	0.1197	0.1196
Echinococcus multilocularis	tubulin epsilon chain	0.0124	0.0609	0.0608
Loa Loa (eye worm)	ceramide kinase	0.0071	0.0316	0.0316
Schistosoma mansoni	hypothetical protein	0.0036	0.0124	0.0124
Giardia lamblia	Beta tubulin	0.0124	0.0609	0.5084
Plasmodium vivax	tubulin alpha chain, putative	0.0231	0.1197	1
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0023	0.0049	0.0048
Trichomonas vaginalis	tubulin, putative	0.0054	0.0221	0.1842
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0231	0.1197	0.1196
Mycobacterium tuberculosis	Cell division protein FtsZ	0.0054	0.0221	0.022
Toxoplasma gondii	exonuclease III APE	0.0023	0.0049	0.0401
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0049	0.0192	0.0191
Leishmania major	alpha tubulin	0.0231	0.1197	0.6189
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0017	0.0017	0.0016
Trichomonas vaginalis	tubulin beta chain, putative	0.007	0.0311	0.2596
Schistosoma mansoni	tyrosine kinase	0.009	0.0419	0.0418
Leishmania major	beta tubulin	0.0124	0.0609	0.3147
Trypanosoma cruzi	Diacylglycerol kinase catalytic domain containing protein, putative	0.0071	0.0316	0.1632
Brugia malayi	intermediate filament protein	0.003	0.0088	0.067
Trypanosoma brucei	trypanothione reductase	0.004	0.0147	0.0754
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0092	0.0432	0.0431
Entamoeba histolytica	hypothetical protein, conserved	0.1829	1	1
Trypanosoma brucei	tubulin gamma chain	0.0124	0.0609	0.3147
Plasmodium vivax	diacylglycerol kinase, putative	0.0071	0.0316	0.2637
Schistosoma mansoni	tyrosine kinase	0.0167	0.0845	0.0844
Brugia malayi	Cell division protein ftsZ	0.0054	0.0221	0.1696
Plasmodium falciparum	diacylglycerol kinase, putative	0.0071	0.0316	0.2637
Echinococcus granulosus	Tubulin beta 2C chain	0.0124	0.0609	0.0608
Brugia malayi	Latrophilin receptor protein 2	0.0017	0.0017	0.0121
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0051	0.0206	0.1063
Giardia lamblia	Delta tubulin	0.0054	0.0221	0.1842
Toxoplasma gondii	thioredoxin reductase	0.004	0.0147	0.1218
Schistosoma mansoni	cpg binding protein	0.0023	0.0053	0.0052
Plasmodium vivax	tubulin epsilon chain, putative	0.0124	0.0609	0.5084
Loa Loa (eye worm)	hypothetical protein	0.025	0.13	0.13
Plasmodium falciparum	tubulin gamma chain	0.0124	0.0609	0.5084
Leishmania major	alpha tubulin	0.0231	0.1197	0.6189
Loa Loa (eye worm)	tubulin beta chain	0.0054	0.0221	0.0221
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0231	0.1197	1
Brugia malayi	Tubulin alpha-2 chain	0.0231	0.1197	0.9206
Schistosoma mansoni	hypothetical protein	0.0017	0.0017	0.0016
Schistosoma mansoni	hypothetical protein	0.0017	0.0017	0.0016
Echinococcus multilocularis	beta tubulin	0.0124	0.0609	0.0608
Leishmania major	alpha tubulin	0.0231	0.1197	0.6189
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0049	0.0192	0.0191
Echinococcus granulosus	alpha tubulin	0.0231	0.1197	0.1196
Echinococcus granulosus	Diacylglycerol kinase zeta	0.0071	0.0316	0.0315
Loa Loa (eye worm)	beta-tubulin	0.0124	0.0609	0.0609
Trichomonas vaginalis	diacylglycerol kinase, putative	0.0071	0.0316	0.2637
Echinococcus granulosus	tubulin alpha chain	0.0231	0.1197	0.1196
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0167	0.0845	0.0845
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0092	0.0432	0.0431
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0231	0.1197	0.1196
Trichomonas vaginalis	tubulin beta chain, putative	0.0231	0.1197	1
Trichomonas vaginalis	tubulin gamma chain, putative	0.0124	0.0609	0.5084
Trypanosoma brucei	alpha tubulin	0.0231	0.1197	0.6189
Trichomonas vaginalis	tubulin, putative	0.0124	0.0609	0.5084
Plasmodium vivax	tubulin beta chain, putative	0.0124	0.0609	0.5084
Loa Loa (eye worm)	tubulin alpha 2	0.0177	0.0899	0.0899
Trypanosoma cruzi	epsilon tubulin, putative	0.0124	0.0609	0.3147
Trichomonas vaginalis	conserved hypothetical protein	0.0071	0.0316	0.2637
Brugia malayi	Tubulin gamma chain	0.0124	0.0609	0.468
Echinococcus multilocularis	lamin dm0	0.003	0.0088	0.0087
Schistosoma mansoni	diacylglycerol kinase theta	0.0071	0.0316	0.0315
Trypanosoma cruzi	diacylglycerol kinase, putative	0.0071	0.0316	0.1632
Leishmania major	beta tubulin	0.0124	0.0609	0.3147
Leishmania major	beta tubulin	0.0124	0.0609	0.3147
Echinococcus multilocularis	tubulin delta chain	0.0054	0.0221	0.022
Schistosoma mansoni	tubulin subunit alpha	0.0231	0.1197	0.1196
Brugia malayi	RNA binding protein	0.0068	0.0297	0.2278
Loa Loa (eye worm)	tubulin beta-1 chain	0.0124	0.0609	0.0609
Brugia malayi	diacylglycerol kinase	0.0071	0.0316	0.2427
Entamoeba histolytica	diacylglycerol kinase, putative	0.0071	0.0316	0.0269
Brugia malayi	Intermediate filament tail domain containing protein	0.003	0.0088	0.067
Brugia malayi	Cytochrome P450 family protein	0.0021	0.0038	0.0284
Trichomonas vaginalis	ap endonuclease, putative	0.0023	0.0049	0.0401
Schistosoma mansoni	tubulin subunit beta	0.0054	0.0221	0.022
Schistosoma mansoni	tyrosine kinase	0.0089	0.0413	0.0413
Trichomonas vaginalis	bmru protein, putative	0.0071	0.0316	0.2637
Brugia malayi	Furin-like cysteine rich region family protein	0.0167	0.0845	0.6498
Brugia malayi	tubulin alpha chain - mouse	0.0231	0.1197	0.9206
Echinococcus multilocularis	tubulin, beta 4A class IVa	0.0124	0.0609	0.0608
Leishmania major	alpha tubulin	0.0231	0.1197	0.6189
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0047	0.0182	0.0181
Trypanosoma brucei	zeta tubulin	0.0054	0.0221	0.114
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0124	0.0124
Echinococcus granulosus	tubulin beta 4A class IVa	0.0124	0.0609	0.0608
Mycobacterium ulcerans	hypothetical protein	0.1829	1	1
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0124	0.0609	0.5084
Echinococcus granulosus	Tubulin beta 2C chain	0.0124	0.0609	0.0608
Echinococcus granulosus	beta tubulin	0.0124	0.0609	0.0608
Echinococcus multilocularis	Tubulin beta 2C chain	0.0124	0.0609	0.0608
Trypanosoma brucei	alpha tubulin	0.0231	0.1197	0.6189
Brugia malayi	alpha-tubulin	0.0231	0.1197	0.9206
Schistosoma mansoni	tubulin subunit gamma	0.0124	0.0609	0.0608
Brugia malayi	Tubulin alpha-2 chain	0.0231	0.1197	0.9206
Trypanosoma cruzi	Sphingosine kinase	0.0071	0.0316	0.1632
Echinococcus multilocularis	hypothetical protein	0.0231	0.1197	0.1196
Leishmania major	beta tubulin	0.0124	0.0609	0.3147
Mycobacterium tuberculosis	Diacylglycerol kinase	0.0071	0.0316	0.0315
Echinococcus multilocularis		0.0052	0.0209	0.0208
Loa Loa (eye worm)	tubulin beta chain	0.0124	0.0609	0.0609
Trypanosoma brucei	beta tubulin	0.0124	0.0609	0.3147
Brugia malayi	exodeoxyribonuclease III family protein	0.0023	0.0049	0.0369
Giardia lamblia	Alpha-tubulin	0.0231	0.1197	1
Leishmania major	cytochrome p450-like protein	0.0021	0.0038	0.0191
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0014	0.0003	0.0002
Brugia malayi	RNA recognition motif domain containing protein	0.0068	0.0297	0.2278
Entamoeba histolytica	diacylglycerol kinase, putative	0.0071	0.0316	0.0269
Echinococcus multilocularis	tubulin subunit beta	0.0124	0.0609	0.0608
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.009	0.0419	0.0418
Plasmodium falciparum	tubulin beta chain	0.0124	0.0609	0.5084
Entamoeba histolytica	tubulin family protein	0.0124	0.0609	0.0563
Schistosoma mansoni	proteasome subunit alpha 6 (T01 family)	0.0071	0.0316	0.0315
Loa Loa (eye worm)	tubulin alpha chain	0.0231	0.1197	0.1197
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0023	0.0049	0.0401
Schistosoma mansoni	sphingosine kinase A B	0.1829	1	1
Entamoeba histolytica	diacylglycerol kinase, putative	0.0071	0.0316	0.0269
Trichomonas vaginalis	ap endonuclease, putative	0.0023	0.0049	0.0401
Trichomonas vaginalis	tubulin beta chain, putative	0.0231	0.1197	1
Schistosoma mansoni	tubulin subunit beta	0.0124	0.0609	0.0608
Schistosoma mansoni	tyrosine kinase	0.0089	0.0413	0.0413
Loa Loa (eye worm)	intermediate filament protein	0.003	0.0088	0.0088
Loa Loa (eye worm)	glutathione reductase	0.004	0.0147	0.0147
Loa Loa (eye worm)	cytochrome P450 family protein	0.0021	0.0038	0.0038
Echinococcus granulosus	tubulin delta chain	0.0054	0.0221	0.022
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0049	0.0192	0.0192
Echinococcus multilocularis	sphingosine kinase 1	0.1829	1	1
Plasmodium falciparum	tubulin delta chain, putative	0.0054	0.0221	0.1842
Leishmania major	diacylglycerol kinase-like protein	0.0071	0.0316	0.1632
Leishmania major	trypanothione reductase	0.004	0.0147	0.0754
Schistosoma mansoni	hypothetical protein	0.0051	0.0204	0.0203
Schistosoma mansoni	tubulin subunit alpha	0.0231	0.1197	0.1196
Echinococcus multilocularis	tubulin alpha 1C chain	0.0231	0.1197	0.1196
Giardia lamblia	Epsilon tubulin	0.0054	0.0221	0.1842
Echinococcus granulosus	thioredoxin glutathione reductase	0.0041	0.015	0.0149
Schistosoma mansoni	tar DNA-binding protein	0.0068	0.0297	0.0296
Wolbachia endosymbiont of Brugia malayi	cell division protein FtsZ	0.0054	0.0221	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0053	0.0217	0.0217
Mycobacterium tuberculosis	Probable oxidoreductase	0.0103	0.0489	0.0488
Onchocerca volvulus		0.003	0.0088	0.1566
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0173	0.0875	0.4522
Trichomonas vaginalis	diacylglycerol kinase, zeta, iota, putative	0.0071	0.0316	0.2637
Echinococcus multilocularis	Tubulin beta 2C chain	0.0124	0.0609	0.0608
Brugia malayi	Cytochrome P450 family protein	0.0021	0.0038	0.0284
Brugia malayi	Eye-specific diacylglycerol kinase	0.0071	0.0316	0.2427
Schistosoma mansoni	tyrosine kinase	0.0089	0.0413	0.0413
Trichomonas vaginalis	tubulin alpha chain, putative	0.0124	0.0609	0.5084
Schistosoma mansoni	tar DNA-binding protein	0.0068	0.0297	0.0296
Echinococcus granulosus	lamin	0.003	0.0088	0.0087
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0023	0.0049	0.0248
Schistosoma mansoni	cpg binding protein	0.0022	0.0046	0.0045
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0021	0.0038	0.0037
Trichomonas vaginalis	sphingosine kinase, putative	0.0071	0.0316	0.2637
Loa Loa (eye worm)	tubulin alpha 2	0.0107	0.0512	0.0512
Echinococcus multilocularis	ceramide kinase	0.0071	0.0316	0.0315
Echinococcus multilocularis	epidermal growth factor receptor	0.0167	0.0845	0.0844
Leishmania major	beta tubulin	0.0124	0.0609	0.3147
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0161	0.0809	0.6758
Echinococcus multilocularis	musashi	0.003	0.0088	0.0087
Schistosoma mansoni	tyrosine kinase	0.0053	0.0218	0.0217
Echinococcus multilocularis	epidermal growth factor receptor	0.009	0.0419	0.0418
Trypanosoma cruzi	trypanothione reductase, putative	0.004	0.0147	0.0754
Echinococcus multilocularis	tubulin subunit TubB	0.0231	0.1197	0.1196
Onchocerca volvulus		0.007	0.0311	0.9822
Mycobacterium ulcerans	hypothetical protein	0.0192	0.0982	0.0981
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0068	0.0297	0.0297
Schistosoma mansoni	tubulin subunit beta	0.0124	0.0609	0.0608
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0231	0.1197	0.1196
Leishmania major	alpha tubulin	0.0231	0.1197	0.6189
Echinococcus multilocularis	tubulin alpha 3 chain	0.0231	0.1197	0.1196
Brugia malayi	diacylglycerol kinase	0.0071	0.0316	0.2427
Echinococcus granulosus	tubulin alpha chain	0.0231	0.1197	0.1196
Trichomonas vaginalis	tubulin alpha chain, putative	0.007	0.0311	0.2596
Echinococcus granulosus	Tubulin beta 2C chain	0.0124	0.0609	0.0608
Trypanosoma brucei	epsilon tubulin	0.0124	0.0609	0.3147
Echinococcus granulosus	Tubulin alpha 1 chain	0.0231	0.1197	0.1196
Plasmodium vivax	diacylglycerol kinase, putative	0.0071	0.0316	0.2637
Schistosoma mansoni	alpha tubulin	0.0231	0.1197	0.1196
Trypanosoma brucei	beta tubulin	0.0124	0.0609	0.3147
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0124	0.0609	0.5084
Brugia malayi	hypothetical protein	0.0071	0.0316	0.2427
Onchocerca volvulus		0.003	0.0088	0.1566
Echinococcus granulosus	tubulin alpha chain	0.0231	0.1197	0.1196
Loa Loa (eye worm)	cytochrome P450 family protein	0.0021	0.0038	0.0038
Echinococcus granulosus	tubulin epsilon chain	0.0124	0.0609	0.0608
Loa Loa (eye worm)	tubulin alpha 2	0.0177	0.0899	0.0899
Giardia lamblia	Beta tubulin	0.0124	0.0609	0.5084
Toxoplasma gondii	alpha tubulin TUBA1	0.0231	0.1197	1
Mycobacterium ulcerans	diacylglycerol kinase	0.0071	0.0316	0.0315
Trichomonas vaginalis	diacylglycerol kinase, putative	0.0071	0.0316	0.2637
Echinococcus multilocularis	tubulin alpha chain	0.0231	0.1197	0.1196
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0023	0.0049	0.2175
Trypanosoma cruzi	tubulin gamma chain	0.0124	0.0609	0.3147
Plasmodium falciparum	alpha tubulin 1	0.0231	0.1197	1
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0365	0.1933	1
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0054	0.0221	0.1842
Trypanosoma brucei	zeta tubulin, putative	0.0054	0.0221	0.114
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0085	0.0085
Brugia malayi	Tubulin beta-1 chain	0.0124	0.0609	0.468
Trypanosoma cruzi	zeta tubulin, putative	0.0054	0.0221	0.114
Toxoplasma gondii	beta tubulin	0.0124	0.0609	0.5084
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0023	0.0049	0.2175
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0017	0.0017	0.0016
Brugia malayi	Protein kinase domain containing protein	0.0053	0.0218	0.1672
Schistosoma mansoni	intermediate filament proteins	0.003	0.0088	0.0087
Trypanosoma cruzi	epsilon tubulin, putative	0.0124	0.0609	0.3147
Trichomonas vaginalis	tubulin beta chain, putative	0.0231	0.1197	1
Trichomonas vaginalis	tubulin beta chain, putative	0.0231	0.1197	1
Trichomonas vaginalis	conserved hypothetical protein	0.0054	0.0221	0.1842
Leishmania major	beta tubulin	0.0124	0.0609	0.3147
Schistosoma mansoni	alpha tubulin	0.0231	0.1197	0.1196
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0217	0.0217
Trichomonas vaginalis	tubulin alpha chain, putative	0.0124	0.0609	0.5084
Trichomonas vaginalis	tubulin beta chain, putative	0.0231	0.1197	1
Leishmania major	alpha tubulin	0.0231	0.1197	0.6189
Leishmania major	beta tubulin	0.0124	0.0609	0.3147
Loa Loa (eye worm)	diacylglycerol kinase 2	0.0071	0.0316	0.0316
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0023	0.0049	0.0048
Trichomonas vaginalis	tubulin beta chain, putative	0.0231	0.1197	1
Echinococcus multilocularis	Tubulin beta 2C chain	0.0124	0.0609	0.0608
Echinococcus multilocularis	tubulin beta 1 chain	0.0124	0.0609	0.0608
Loa Loa (eye worm)	BEN-1 protein	0.0124	0.0609	0.0609
Schistosoma mansoni	hypothetical protein	0.0017	0.0017	0.0016
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0062	0.0268	0.1383
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0022	0.0046	0.0046
Brugia malayi	beta-tubulin, identical	0.0124	0.0609	0.468
Echinococcus multilocularis	Diacylglycerol kinase theta	0.0071	0.0316	0.0315
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0017	0.0017	0.0017
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0053	0.0217	0.1666
Loa Loa (eye worm)	hypothetical protein	0.0177	0.0899	0.0899
Toxoplasma gondii	beta-1 tubulin, putative	0.0124	0.0609	0.5084
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0092	0.0432	0.0431
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0316	0.0316
Trypanosoma cruzi	cytochrome P450, putative	0.0021	0.0038	0.0191
Leishmania major	beta tubulin	0.0124	0.0609	0.3147
Trypanosoma cruzi	Sphingosine kinase	0.0071	0.0316	0.1632
Echinococcus multilocularis	geminin	0.0181	0.0922	0.0921
Loa Loa (eye worm)	hypothetical protein	0.003	0.0088	0.0088
Trichomonas vaginalis	bmru protein, putative	0.0071	0.0316	0.2637
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0365	0.1933	1
Treponema pallidum	cell division protein FtsZ	0.0054	0.0221	1
Echinococcus multilocularis	tubulin alpha chain	0.0231	0.1197	0.1196
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0051	0.0204	0.1567
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0049	0.0192	0.0191
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0103	0.0489	0.0488

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	0.0586 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	3.1623 uM	PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 12.5893 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	18.526 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	= 25.1189 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	28.1838 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636]	ChEMBL.	No reference
Potency (functional)	56.2341 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404]	ChEMBL.	No reference
Potency (functional)	100 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1422862

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1307947