Detailed information for compound 1322576

Basic information

Technical information
  • TDR Targets ID: 1322576
  • Name: [4-(benzoyloxy)-2-(benzoyloxymethyl)-5-methox yoxolan-3-yl] benzoate
  • MW: 476.475 | Formula: C27H24O8
  • H donors: 0 H acceptors: 3 LogP: 4.71 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC1OC(C(C1OC(=O)c1ccccc1)OC(=O)c1ccccc1)COC(=O)c1ccccc1
  • InChi: 1S/C27H24O8/c1-31-27-23(35-26(30)20-15-9-4-10-16-20)22(34-25(29)19-13-7-3-8-14-19)21(33-27)17-32-24(28)18-11-5-2-6-12-18/h2-16,21-23,27H,17H2,1H3
  • InChiKey: XJKNQPQTQXKNOC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [4-(benzoyloxy)-2-(benzoyloxymethyl)-5-methoxy-tetrahydrofuran-3-yl] benzoate
  • benzoic acid [5-methoxy-4-(oxo-phenylmethoxy)-2-[(oxo-phenylmethoxy)methyl]-3-tetrahydrofuranyl] ester
  • benzoic acid [4-(benzoyloxy)-2-(benzoyloxymethyl)-5-methoxy-tetrahydrofuran-3-yl] ester
  • [5-methoxy-4-phenylcarbonyloxy-2-(phenylcarbonyloxymethyl)oxolan-3-yl] benzoate
  • 7473-42-9
  • 42793-97-5
  • Methyl tri-O-benzoyl-.alpha.-d-arabinofuranoside
  • T0512-5255
  • Methyl .beta.-d-xyloside tribenzoate
  • ST5411157
  • NSC170260
  • Methyl .beta.-d-riboside tribenzoate
  • NSC400281

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens K(lysine) acetyltransferase 2A Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Neospora caninum hypothetical protein Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Theileria parva histone acetyltransferase Gcn5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Entamoeba histolytica acetyltransferase, GNAT family Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis bromodomain-containing protein, putative Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium falciparum histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Babesia bovis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium knowlesi histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium berghei histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium yoelii histone acetyltransferase GCN5-related Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Toxoplasma gondii histone lysine acetyltransferase GCN5-A Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Toxoplasma gondii histone lysine acetyltransferase GCN5-B Get druggable targets OG5_127781 All targets in OG5_127781
Neospora caninum Bromodomain containing protein, related Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum ko:K06062 p300/CBP-associated factor, putative Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium vivax histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Cryptosporidium hominis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Brugia malayi acetyltransferase, GNAT family protein Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis Get druggable targets OG5_127781 All targets in OG5_127781
Giardia lamblia Histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Cryptosporidium parvum GCN5 like acetylase + bromodomain Get druggable targets OG5_127781 All targets in OG5_127781
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.046 0.2906 1
Brugia malayi follicle stimulating hormone receptor 0.0019 0.0021 0.0074
Brugia malayi Copper type II ascorbate-dependent monooxygenase, N-terminal domain containing protein 0.0124 0.0709 0.244
Entamoeba histolytica hypothetical protein 0.0055 0.026 0.0342
Echinococcus granulosus g protein coupled receptor 0.0019 0.0021 0.0021
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0019 0.0021 0.0074
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0019 0.0021 0.0074
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0119 0.0674 0.0674
Leishmania major hypothetical protein, conserved 0.0025 0.006 0.0182
Trypanosoma brucei ABC transporter of the mitochondrion, putative 0.004 0.0159 0.0478
Echinococcus granulosus multidrug resistance protein 1 0.0089 0.0479 0.0479
Giardia lamblia Histone acetyltransferase GCN5 0.0047 0.0207 1
Brugia malayi diacylglycerol acyltransferase 0.0125 0.0717 0.2469
Loa Loa (eye worm) hypothetical protein 0.004 0.0159 0.0546
Leishmania major ATP-binding cassette protein subfamily B, member 3, putative 0.004 0.0159 0.0478
Plasmodium falciparum multidrug resistance-associated protein 1 0.004 0.0159 0.2175
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0019 0.0021 0.0021
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0127 0.073 0.073
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.0074
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0021 0.0021
Brugia malayi ABC transporter transmembrane region family protein 0.004 0.0159 0.0546
Brugia malayi putative neuropeptide receptor 0.0019 0.0021 0.0074
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.0074
Brugia malayi G protein-coupled receptor 0.0019 0.0021 0.0074
Schistosoma mansoni neuropeptide F-like receptor 0.0019 0.0021 0.0074
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 3 0.0055 0.026 0.0893
Trypanosoma brucei glycerol uptake protein, putative 0.0021 0.0036 0.0109
Echinococcus multilocularis neuropeptide receptor 0.0019 0.0021 0.0021
Entamoeba histolytica P-glycoprotein-5 0.0127 0.073 0.1062
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0127 0.073 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0021 0.0021
Echinococcus granulosus multidrug resistance associated protein 1 0.004 0.0159 0.0159
Echinococcus multilocularis neuropeptide s receptor 0.0019 0.0021 0.0021
Echinococcus granulosus membrane bound acyltransferase:hhat 0.0021 0.0036 0.0036
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0019 0.0021 0.0074
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0021 0.0021
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0019 0.0021 0.0021
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.005 0.0228 0.3129
Entamoeba histolytica hypothetical protein 0.004 0.0159 0.0188
Leishmania major ATP-binding cassette protein subfamily C, member 2, putative 0.004 0.0159 0.0478
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.0074
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0021 0.0074
Echinococcus multilocularis allatostatin A receptor 0.0019 0.0021 0.0021
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.004 0.0159 0.1765
Echinococcus granulosus o acyltransferase membrane bound domain 0.0021 0.0036 0.0036
Echinococcus granulosus neuropeptide receptor A26 0.0019 0.0021 0.0021
Entamoeba histolytica P-glyco protein 6, putative 0.0127 0.073 0.1062
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.0074
Schistosoma mansoni hypothetical protein 0.0019 0.0021 0.0074
Plasmodium falciparum multidrug resistance protein 2 0.004 0.0159 0.2175
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0127 0.073 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.0074
Toxoplasma gondii hypothetical protein 0.0021 0.0036 0.0497
Schistosoma mansoni multidrug resistance protein 0.004 0.0159 0.0546
Brugia malayi G protein-coupled receptor F59B2.13 0.0019 0.0021 0.0074
Schistosoma mansoni multidrug resistance protein 0.0127 0.073 0.2512
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.004 0.0159 0.5
Echinococcus granulosus peptide allatostatin:somatostatin 0.0019 0.0021 0.0021
Schistosoma mansoni alpha-1 adrenergic receptor 0.0019 0.0021 0.0074
Echinococcus multilocularis smad 0.0024 0.0054 0.0054
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0051 0.0235 0.3222
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.0074
Trypanosoma brucei p-glycoprotein 0.004 0.0159 0.0478
Loa Loa (eye worm) neuropeptide F receptor 0.0019 0.0021 0.0074
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0021 0.0074
Brugia malayi Tachykinin-like peptides receptor 99D 0.0019 0.0021 0.0074
Giardia lamblia Multidrug resistance-associated protein 1 0.004 0.0159 0.1577
Schistosoma mansoni amine GPCR 0.0019 0.0021 0.0074
Echinococcus multilocularis neuropeptide Y receptor 0.0019 0.0021 0.0021
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0019 0.0021 0.0074
Trypanosoma brucei sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0523 0.332 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.0074
Schistosoma mansoni amine GPCR 0.0019 0.0021 0.0074
Echinococcus granulosus o acyltransferase membrane bound domain 0.0021 0.0036 0.0036
Schistosoma mansoni hypothetical protein 0.0046 0.02 0.0689
Entamoeba histolytica hypothetical protein 0.0055 0.026 0.0342
Loa Loa (eye worm) hypothetical protein 0.0021 0.0036 0.0125
Echinococcus multilocularis mothers against decapentaplegic 5 0.0024 0.0054 0.0054
Trichomonas vaginalis sphingomyelin synthetase, putative 0.0055 0.026 0.322
Echinococcus granulosus multidrug resistance protein 1 0.0127 0.073 0.073
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0019 0.0021 0.0021
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0119 0.0674 0.0674
Schistosoma mansoni smdr1 0.004 0.0159 0.0546
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0019 0.0021 0.0021
Loa Loa (eye worm) hhat protein 0.0021 0.0036 0.0125
Trypanosoma cruzi sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0523 0.332 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0021 0.0021
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0127 0.073 0.5
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 1 0.0055 0.026 0.0893
Echinococcus multilocularis g protein coupled receptor 0.0019 0.0021 0.0021
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1545 1 1
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0127 0.073 1
Plasmodium vivax sphingomyelin synthase 2, putative 0.0055 0.026 0.3557
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0127 0.073 0.2199
Leishmania major glycerol uptake protein, putative 0.0021 0.0036 0.0109
Echinococcus multilocularis multidrug resistance protein 1 0.0127 0.073 0.073
Schistosoma mansoni multidrug resistance protein 0.004 0.0159 0.0546
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0021 0.0036 0.0125
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.006 0.0182
Echinococcus multilocularis fmrfamide receptor 0.0019 0.0021 0.0021
Loa Loa (eye worm) G-protein coupled receptor 0.0019 0.0021 0.0074
Echinococcus granulosus histone acetyltransferase KAT2B 0.0051 0.0235 0.0235
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.006 0.0827
Trypanosoma brucei sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0523 0.332 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0019 0.0021 0.0021
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0019 0.0021 0.0021
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.006 0.0827
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.0074
Plasmodium falciparum plasmepsin VI 0.005 0.0228 0.3129
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0021 0.0036 0.0036
Loa Loa (eye worm) MH2 domain-containing protein 0.0024 0.0054 0.0186
Echinococcus multilocularis ATP binding cassette sub family B 0.004 0.0159 0.0159
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0019 0.0021 0.0021
Schistosoma mansoni hypothetical protein 0.0019 0.0021 0.0074
Schistosoma mansoni histamine h1 receptor 0.0019 0.0021 0.0074
Schistosoma mansoni smad1 5 8 and 0.0024 0.0054 0.0186
Brugia malayi hypothetical protein 0.0019 0.0021 0.0074
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0021 0.0074
Schistosoma mansoni smad1 5 8 and 0.0024 0.0054 0.0186
Echinococcus granulosus G protein coupled receptor 139 0.0019 0.0021 0.0021
Plasmodium falciparum diacylglycerol O-acyltransferase 0.0125 0.0717 0.9829
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.015 0.1635
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0127 0.073 1
Schistosoma mansoni opsin-like receptor 0.0019 0.0021 0.0074
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.046 0.2906 1
Echinococcus granulosus neuropeptide FF receptor 2 0.0019 0.0021 0.0021
Trypanosoma cruzi glycerol uptake protein, putative 0.0021 0.0036 0.0109
Brugia malayi MBOAT family protein 0.0021 0.0036 0.0125
Echinococcus multilocularis lysophospholipid acyltransferase 7 0.0021 0.0036 0.0036
Trichomonas vaginalis taga, putative 0.0127 0.073 1
Brugia malayi hypothetical protein 0.0016 0.0003 0.001
Loa Loa (eye worm) MBOAT family protein 0.0021 0.0036 0.0125
Echinococcus granulosus diacylglycerol O acyltransferase 1 0.0125 0.0717 0.0717
Schistosoma mansoni hypothetical protein 0.0019 0.0021 0.0074
Trichomonas vaginalis sphingomyelin synthetase, putative 0.0055 0.026 0.322
Echinococcus multilocularis peptidyl glycine alpha amidating monooxygenase 0.046 0.2906 0.2906
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.004 0.0159 0.2175
Mycobacterium ulcerans drugs-transport transmembrane ATP-binding protein ABC transporter 0.004 0.0159 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0021 0.0074
Leishmania major ABC-thiol transporter 0.004 0.0159 0.0478
Loa Loa (eye worm) hypothetical protein 0.0038 0.015 0.0515
Echinococcus multilocularis diacylglycerol O acyltransferase 1 0.0125 0.0717 0.0717
Schistosoma mansoni hypothetical protein 0.0021 0.0036 0.0125
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.0074
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.0074
Loa Loa (eye worm) MH1 domain-containing protein 0.0024 0.0054 0.0186
Schistosoma mansoni amine GPCR 0.0019 0.0021 0.0074
Schistosoma mansoni neuropeptide receptor 0.0019 0.0021 0.0074
Schistosoma mansoni dopamine-beta-monooxygenase 0.0244 0.1496 0.5148
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0019 0.0021 0.0074
Leishmania major ATP-binding cassette protein subfamily C, member 8, putative 0.004 0.0159 0.0478
Loa Loa (eye worm) hypothetical protein 0.0021 0.0036 0.0125
Loa Loa (eye worm) latrophilin receptor protein 2 0.0046 0.02 0.0689
Echinococcus multilocularis ATP binding cassette sub family B 0.004 0.0159 0.0159
Echinococcus multilocularis neuropeptides capa receptor 0.0019 0.0021 0.0021
Loa Loa (eye worm) MBOAT family protein 0.0021 0.0036 0.0125
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0021 0.0021
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0046 0.02 0.02
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0019 0.0021 0.0074
Echinococcus granulosus multidrug resistance protein 1 0.0127 0.073 0.073
Brugia malayi multidrug resistance related protein 1 0.004 0.0159 0.0546
Brugia malayi neuropeptide F receptor 0.0019 0.0021 0.0074
Plasmodium falciparum ABC transporter B family member 4, putative 0.004 0.0159 0.2175
Trypanosoma cruzi multidrug resistance protein E, putative 0.004 0.0159 0.0478
Loa Loa (eye worm) aspartic protease BmAsp-2 0.005 0.0228 0.0786
Entamoeba histolytica P-glycoprotein-2, putative 0.0127 0.073 0.1062
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0019 0.0021 0.0074
Entamoeba histolytica multidrug resistance protein, putative 0.004 0.0159 0.0188
Loa Loa (eye worm) MBOAT family protein 0.0021 0.0036 0.0125
Loa Loa (eye worm) hypothetical protein 0.01 0.055 0.1893
Schistosoma mansoni smad1 5 8 and 0.0024 0.0054 0.0186
Echinococcus granulosus ATP binding cassette sub family B 0.004 0.0159 0.0159
Loa Loa (eye worm) ABC transporter 0.004 0.0159 0.0546
Echinococcus granulosus alpha 1A adrenergic receptor 0.0019 0.0021 0.0021
Echinococcus granulosus neuropeptide Y receptor 0.0019 0.0021 0.0021
Entamoeba histolytica P-glycoprotein 5, putative 0.0038 0.015 0.0174
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0019 0.0021 0.0021
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.0125 0.0717 0.2469
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0019 0.0021 0.0021
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0021 0.0021
Schistosoma mansoni multidrug resistance protein 0.004 0.0159 0.0546
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.004 0.0159 0.5
Echinococcus granulosus ATP binding cassette sub family B 0.004 0.0159 0.0159
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0127 0.073 1
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0127 0.073 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.0074
Echinococcus granulosus g protein coupled receptor 0.0019 0.0021 0.0021
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0089 0.0479 0.6381
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.0074
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.026 0.026
Schistosoma mansoni hypothetical protein 0.0046 0.02 0.0689
Schistosoma mansoni multidrug resistance protein 0.0038 0.015 0.0515
Trichomonas vaginalis ABC transporter, putative 0.0127 0.073 1
Echinococcus granulosus multidrug resistance associated protein 7 0.004 0.0159 0.0159
Brugia malayi multidrug resistance protein 3 0.0127 0.073 0.2512
Plasmodium vivax ABC transporter B family member 6, putative 0.004 0.0159 0.2175
Schistosoma mansoni biogenic amine receptor 0.0019 0.0021 0.0074
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0038 0.015 0.1635
Entamoeba histolytica P-glycoprotein-2 0.0127 0.073 0.1062
Plasmodium vivax ABC transporter B family member 7, putative 0.004 0.0159 0.2175
Brugia malayi G-protein coupled receptor 0.0019 0.0021 0.0074
Trypanosoma brucei inositol phosphorylceramide synthase 0.0055 0.026 0.0782
Schistosoma mansoni biogenic amine receptor 0.0019 0.0021 0.0074
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0127 0.073 0.073
Loa Loa (eye worm) multidrug resistance protein 3 0.0127 0.073 0.2512
Echinococcus granulosus hypothetical protein 0.0019 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0104 0.058 0.1995
Schistosoma mansoni opsin-like receptor 0.0019 0.0021 0.0074
Entamoeba histolytica ATP-binding cassette protein, putative 0.004 0.0159 0.0188
Echinococcus multilocularis neuropeptides capa receptor 0.0019 0.0021 0.0021
Brugia malayi ABC transporter transmembrane region family protein 0.0038 0.015 0.0515
Trypanosoma cruzi sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0523 0.332 1
Echinococcus granulosus sterol O acyltransferase 1 0.0021 0.0036 0.0036
Brugia malayi ABC transporter family protein 0.004 0.0159 0.0546
Echinococcus multilocularis sex peptide receptor 0.0019 0.0021 0.0021
Echinococcus multilocularis neuropeptide receptor A26 0.0019 0.0021 0.0021
Echinococcus granulosus neuropeptide s receptor 0.0019 0.0021 0.0021
Plasmodium vivax plasmepsin IV, putative 0.005 0.0228 0.3129
Echinococcus multilocularis neuropeptide Y receptor 0.0019 0.0021 0.0021
Entamoeba histolytica hypothetical membrane-spanning protein 0.0055 0.026 0.0342
Echinococcus multilocularis orexin receptor type 2 0.0019 0.0021 0.0021
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0127 0.073 0.073
Loa Loa (eye worm) hypothetical protein 0.0146 0.0852 0.2931
Echinococcus granulosus smad 0.0024 0.0054 0.0054
Trichomonas vaginalis ABC transporter, putative 0.0127 0.073 1
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0127 0.073 1
Brugia malayi MH2 domain containing protein 0.0024 0.0054 0.0186
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.006 0.0827
Echinococcus granulosus tm gpcr rhodopsin 0.0019 0.0021 0.0021
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0021 0.0036 0.0036
Echinococcus granulosus g protein coupled receptor 0.0019 0.0021 0.0021
Schistosoma mansoni peptidyl-glycine monooxygenase 0.046 0.2906 1
Plasmodium falciparum histone acetyltransferase GCN5 0.0047 0.0207 0.2838
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.006 0.0182
Schistosoma mansoni biogenic amine receptor 0.0019 0.0021 0.0074
Trypanosoma cruzi GUP1, putative 0.0021 0.0036 0.0109
Plasmodium falciparum plasmepsin I 0.005 0.0228 0.3129
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.0074
Schistosoma mansoni neuropeptide F-like receptor 0.0019 0.0021 0.0074
Schistosoma mansoni leukocyte receptor cluster (lrc) member 4 protein 0.0021 0.0036 0.0125
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.0074
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0019 0.0021 0.0074
Schistosoma mansoni adenoreceptor 0.0019 0.0021 0.0074
Schistosoma mansoni Smad4 0.0024 0.0054 0.0186
Plasmodium vivax sphingomyelin synthase 1, putative 0.0055 0.026 0.3557
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.0074
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.0074
Echinococcus multilocularis ATP binding cassette sub family B 0.004 0.0159 0.0159
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0119 0.0674 0.2319
Loa Loa (eye worm) hypothetical protein 0.0055 0.026 0.0893
Leishmania major glycerol uptake protein, putative 0.0021 0.0036 0.0109
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0019 0.0021 0.0074
Schistosoma mansoni hypothetical protein 0.0019 0.0021 0.0074
Trichomonas vaginalis hypothetical protein 0.0055 0.026 0.322
Plasmodium falciparum multidrug resistance protein 1 0.0127 0.073 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0127 0.073 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.026 0.026
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0019 0.0021 0.0074
Schistosoma mansoni multidrug resistance protein 0.004 0.0159 0.0546
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.0074
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.004 0.0159 0.2175
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.0074
Onchocerca volvulus 0.0127 0.073 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0019 0.0021 0.0074
Toxoplasma gondii acyl-CoA:diacylglycerol acyltransferase 1-related enzyme 0.0125 0.0717 0.9829
Brugia malayi MH1 domain containing protein 0.0024 0.0054 0.0186
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0019 0.0021 0.0074
Echinococcus multilocularis multidrug resistance protein 1 0.0127 0.073 0.073
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0019 0.0021 0.0021
Entamoeba histolytica hypothetical protein 0.0055 0.026 0.0342
Echinococcus granulosus ATP binding cassette sub family B 0.0038 0.015 0.015
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0021 0.0074
Brugia malayi hypothetical protein 0.0019 0.0021 0.0074
Loa Loa (eye worm) hypothetical protein 0.0021 0.0036 0.0125
Echinococcus multilocularis protein cysteine N palmitoyltransferase 0.0021 0.0036 0.0036
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0024 0.0054 0.0054
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0119 0.0674 0.2319
Leishmania major glycerol uptake protein, putative 0.0021 0.0036 0.0109
Schistosoma mansoni amine GPCR 0.0019 0.0021 0.0074
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0127 0.073 1
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0127 0.073 0.073
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0127 0.073 1
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 2 0.0055 0.026 0.0893
Echinococcus granulosus mothers against decapentaplegic 5 0.0024 0.0054 0.0054
Trypanosoma brucei multidrug resistance-associated protein, putative 0.004 0.0159 0.0478
Echinococcus granulosus protein cysteine N palmitoyltransferase 0.0021 0.0036 0.0036
Brugia malayi ABC transporter family protein 0.004 0.0159 0.0546
Loa Loa (eye worm) hypothetical protein 0.0127 0.073 0.2512
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0021 0.0021
Trichomonas vaginalis ABC transporter, putative 0.0127 0.073 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.015 0.0515
Schistosoma mansoni neuropeptide receptor 0.0019 0.0021 0.0074
Schistosoma mansoni neuropeptide receptor 0.0019 0.0021 0.0074
Trichomonas vaginalis bromodomain-containing protein, putative 0.0051 0.0235 0.2868
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0127 0.073 1
Loa Loa (eye worm) hypothetical protein 0.0126 0.0721 0.2481
Brugia malayi MH2 domain containing protein 0.0349 0.2181 0.7506
Schistosoma mansoni zinc finger protein 0.0021 0.0036 0.0125
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.0074
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.004 0.0159 0.5
Entamoeba histolytica ATP-binding cassette protein, putative 0.004 0.0159 0.0188
Brugia malayi Dopamine receptor protein 2 0.0019 0.0021 0.0074
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.004 0.0159 0.2175
Brugia malayi G-protein coupled receptor 0.0019 0.0021 0.0074
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.026 0.0894
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.005 0.0228 0.277
Entamoeba histolytica P-glycoprotein-2, putative 0.0038 0.015 0.0174
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0019 0.0021 0.0021
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0051 0.0235 0.3222
Plasmodium vivax multidrug resistance protein 2, putative 0.004 0.0159 0.2175
Entamoeba histolytica ATP-binding cassette protein, putative 0.004 0.0159 0.0188
Loa Loa (eye worm) hhat protein 0.0021 0.0036 0.0125
Schistosoma mansoni cathepsin D (A01 family) 0.0149 0.0871 0.2997
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0019 0.0021 0.0074
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0019 0.0021 0.0021
Trypanosoma cruzi glycerol uptake protein, putative 0.0021 0.0036 0.0109
Brugia malayi hypothetical protein 0.0019 0.0021 0.0074
Toxoplasma gondii hypothetical protein 0.0055 0.026 0.3557
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0119 0.0674 0.2319
Entamoeba histolytica P-glycoprotein-2 0.0127 0.073 0.1062
Loa Loa (eye worm) hypothetical protein 0.0021 0.0036 0.0125
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0127 0.073 1
Brugia malayi RE15519p 0.0019 0.0021 0.0074
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.026 0.026
Echinococcus multilocularis fmrfamide receptor 0.0019 0.0021 0.0021
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0021 0.0074
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.0074
Trichomonas vaginalis abcb9, putative 0.0127 0.073 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.0074
Brugia malayi Serotonin receptor 0.0019 0.0021 0.0074
Brugia malayi ABC transporter 0.004 0.0159 0.0546
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0021 0.0021
Brugia malayi hypothetical protein 0.0019 0.0021 0.0074
Trypanosoma cruzi ABC transporter, mitochondrial, putative 0.004 0.0159 0.0478
Trypanosoma brucei multidrug resistance protein E 0.004 0.0159 0.0478
Loa Loa (eye worm) ABC transporter transmembrane region family protein 0.004 0.0159 0.0546
Brugia malayi MBOAT family protein 0.0021 0.0036 0.0125
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0019 0.0021 0.0074
Mycobacterium ulcerans component linked with the assembly of cytochrome transport transmembrane ATP-binding protein ABC transporter CydD 0.004 0.0159 0.5
Plasmodium falciparum sphingomyelin synthase 2, putative 0.0055 0.026 0.3557
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0021 0.0074
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0127 0.073 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.026 0.0894
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0019 0.0021 0.0021
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0021 0.0021
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0019 0.0021 0.0074
Schistosoma mansoni hypothetical protein 0.01 0.055 0.1893
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0146 0.0852 0.2931
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.012 0.0685 0.2358
Loa Loa (eye worm) hypothetical protein 0.005 0.0228 0.0786
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0021 0.0021
Echinococcus multilocularis Membrane bound O acyl transferase, MBOAT 0.0021 0.0036 0.0036
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0019 0.0021 0.0074
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0051 0.0235 0.3222
Echinococcus multilocularis neuropeptide FF receptor 2 0.0019 0.0021 0.0021
Echinococcus granulosus neuropeptides capa receptor 0.0019 0.0021 0.0021
Brugia malayi P-glycoprotein-like protein 0.004 0.0159 0.0546
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0021 0.0036 0.0125
Mycobacterium tuberculosis Probable drugs-transport transmembrane ATP-binding protein ABC transporter 0.004 0.0159 0.2175
Trypanosoma cruzi glycerol uptake protein, putative 0.0021 0.0036 0.0109
Schistosoma mansoni multidrug resistance protein 0.004 0.0159 0.0546
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.0074
Schistosoma mansoni smdr2 0.0127 0.073 0.2512
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 1 0.0055 0.026 0.0893
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.0074
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.0074
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.6302 0.6302
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.026 0.026
Toxoplasma gondii aspartyl protease ASP1 0.005 0.0228 0.3129
Echinococcus granulosus orexin receptor type 2 0.0019 0.0021 0.0021
Schistosoma mansoni growth hormone secretagogue receptor 0.0019 0.0021 0.0074
Schistosoma mansoni neuropeptide f receptor 76f 0.0019 0.0021 0.0074
Loa Loa (eye worm) hypothetical protein 0.0055 0.026 0.0893
Echinococcus multilocularis somatostatin receptor 0.0019 0.0021 0.0021
Echinococcus multilocularis serotonin receptor 0.0019 0.0021 0.0021
Brugia malayi ABC transporter family protein 0.004 0.0159 0.0546
Wolbachia endosymbiont of Brugia malayi ABC-type protease secretion system, ATPase and permease component, AprD 0.004 0.0159 0.5
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0127 0.073 1
Brugia malayi MBOAT family protein 0.0021 0.0036 0.0125
Plasmodium falciparum sphingomyelin synthase 1, putative 0.0055 0.026 0.3557
Loa Loa (eye worm) hypothetical protein 0.0046 0.02 0.0689
Echinococcus granulosus 7TM GPCR rhodopsin 0.0019 0.0021 0.0021
Plasmodium vivax multidrug resistance protein 1, putative 0.0127 0.073 1
Entamoeba histolytica P-glycoprotein 6, putative 0.004 0.0159 0.0188
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0127 0.073 0.073
Echinococcus granulosus biogenic amine 5HT receptor 0.0019 0.0021 0.0021
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0127 0.073 1
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0127 0.073 0.073
Loa Loa (eye worm) transcription factor SMAD2 0.0349 0.2181 0.7506
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.005 0.0228 0.0228
Loa Loa (eye worm) hypothetical protein 0.0127 0.073 0.2512
Entamoeba histolytica acetyltransferase, GNAT family 0.0047 0.0207 0.0262
Schistosoma mansoni sterol O-acyltransferase 1 0.0021 0.0036 0.0125
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0046 0.02 0.02
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.0074
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0127 0.073 1
Echinococcus multilocularis neuropeptide receptor 0.0019 0.0021 0.0021
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0046 0.02 0.02
Schistosoma mansoni opsin-like receptor 0.0019 0.0021 0.0074
Trypanosoma brucei multidrug resistance-associated protein, putative 0.004 0.0159 0.0478
Leishmania major ATP-binding cassette protein subfamily B, member 1, putative 0.004 0.0159 0.0478
Brugia malayi MH1 domain containing protein 0.0024 0.0054 0.0186
Brugia malayi hypothetical protein 0.0019 0.0021 0.0074
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0021 0.0021
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0038 0.015 0.1635
Brugia malayi Serotonin receptor 0.0019 0.0021 0.0074
Leishmania major phosphatidylcholine:ceramide cholinephosphotransferase 2 0.0523 0.332 1
Trypanosoma cruzi ABC transporter of the mitochondrion, putative 0.004 0.0159 0.0478
Loa Loa (eye worm) hypothetical protein 0.0025 0.006 0.0208
Echinococcus granulosus allatostatin A receptor 0.0019 0.0021 0.0021
Echinococcus multilocularis sterol O acyltransferase 1 0.0021 0.0036 0.0036
Leishmania major ATP-binding cassette protein subfamily C, member 1, putative 0.004 0.0159 0.0478
Echinococcus granulosus serotonin receptor 0.0019 0.0021 0.0021
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.004 0.0159 0.0478
Echinococcus multilocularis dro:myosuppressin receptor 0.0019 0.0021 0.0021
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0019 0.0021 0.0074
Echinococcus granulosus histone acetyltransferase KAT2B 0.017 0.1011 0.1011
Echinococcus multilocularis multidrug resistance associated protein 1 0.004 0.0159 0.0159
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0175 0.1043 0.3589
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0019 0.0021 0.0074
Loa Loa (eye worm) hypothetical protein 0.0055 0.026 0.0893
Echinococcus multilocularis g protein coupled receptor 0.0019 0.0021 0.0021
Brugia malayi Hhat protein 0.0021 0.0036 0.0125
Brugia malayi AKH receptor 0.0019 0.0021 0.0074
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0127 0.073 1
Toxoplasma gondii ATP-binding cassette sub-family B member 5 0.004 0.0159 0.2175
Giardia lamblia ABC transporter, putative 0.004 0.0159 0.1577
Brugia malayi latrophilin 2 splice variant baaae 0.01 0.055 0.1893
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0019 0.0021 0.0074
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.026 0.0894
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.0074
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0038 0.015 0.1635
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.005 0.0228 0.0786
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.0074
Brugia malayi hypothetical protein 0.004 0.0159 0.0546
Entamoeba histolytica P-glycoprotein 5, putative 0.0127 0.073 0.1062
Brugia malayi hypothetical protein 0.0019 0.0021 0.0074
Loa Loa (eye worm) neuropeptide F receptor 0.0019 0.0021 0.0074
Plasmodium falciparum plasmepsin II 0.005 0.0228 0.3129
Schistosoma mansoni membrane-bound acyltransferase/hhat 0.0021 0.0036 0.0125
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.0074
Mycobacterium leprae PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER 0.004 0.0159 0.5
Trypanosoma brucei ceramide phosphorylethanolamine synthase 0.0055 0.026 0.0782
Echinococcus granulosus tm gpcr rhodopsin 0.0019 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.0074
Plasmodium vivax ABC transporter B family member 5, putative 0.004 0.0159 0.2175
Echinococcus granulosus somatostatin receptor 0.0019 0.0021 0.0021
Plasmodium falciparum sphingomyelin synthase 1, putative 0.0055 0.026 0.3557
Loa Loa (eye worm) hypothetical protein 0.0244 0.1496 0.5148
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0119 0.0674 0.0674
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0046 0.02 0.02
Entamoeba histolytica ABC transporter, putative 0.004 0.0159 0.0188
Leishmania major p-glycoprotein e 0.004 0.0159 0.0478
Echinococcus granulosus TGF beta signal transducer SmadC 0.0024 0.0054 0.0054
Trichomonas vaginalis sphingomyelin synthetase, putative 0.0055 0.026 0.322
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0046 0.02 0.0689
Echinococcus multilocularis multidrug resistance associated protein 7 0.004 0.0159 0.0159
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0019 0.0021 0.0074
Brugia malayi ABC transporter transmembrane region family protein 0.004 0.0159 0.0546
Plasmodium vivax diacylglycerol O-acyltransferase, putative 0.0125 0.0717 0.9829
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.0074
Loa Loa (eye worm) melatonin receptor type 1A 0.0019 0.0021 0.0074
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.026 0.0894
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0051 0.0235 0.2868
Echinococcus multilocularis Smad4 0.0024 0.0054 0.0054
Toxoplasma gondii ABC transporter, putative 0.004 0.0159 0.2175
Leishmania major hypothetical protein, conserved 0.0021 0.0036 0.0109
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0024 0.0054 0.0186
Brugia malayi Dopamine receptor protein 1 0.0019 0.0021 0.0074
Echinococcus multilocularis GPCR, family 2 0.0046 0.02 0.02
Entamoeba histolytica P-glycoprotein-1 0.0127 0.073 0.1062
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.0074
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0126 0.0721 0.0721
Brugia malayi hypothetical protein 0.0025 0.006 0.0208
Plasmodium falciparum ABC transporter B family member 5, putative 0.004 0.0159 0.2175
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0127 0.073 1
Plasmodium falciparum plasmepsin IV 0.005 0.0228 0.3129
Echinococcus granulosus GPCR family 2 0.0046 0.02 0.02
Brugia malayi Sphingomyelin synthase-related 1 0.0055 0.026 0.0893
Echinococcus granulosus neuropeptide receptor 0.0019 0.0021 0.0021
Entamoeba histolytica P-glycoprotein 6, putative 0.004 0.0159 0.0188
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0127 0.073 0.073
Loa Loa (eye worm) acetyltransferase 0.0175 0.1043 0.3589
Echinococcus granulosus Membrane bound O acyl transferase MBOAT 0.0021 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.0074
Plasmodium falciparum multidrug resistance-associated protein 2 0.004 0.0159 0.2175
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0019 0.0021 0.0074
Echinococcus granulosus biogenic amine 5HT receptor 0.0019 0.0021 0.0021
Brugia malayi MH2 domain containing protein 0.0024 0.0054 0.0186
Brugia malayi multidrug Resistance Protein family member (mrp-5), putative 0.004 0.0159 0.0546
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.006 0.0827
Echinococcus multilocularis ATP binding cassette sub family B 0.0126 0.0721 0.0721
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha 0.0125 0.0717 0.9829
Echinococcus granulosus lysophospholipid acyltransferase 7 0.0021 0.0036 0.0036
Brugia malayi Smad1 0.0024 0.0054 0.0186
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.0074
Plasmodium vivax ABC transporter B family member 4, putative 0.004 0.0159 0.2175
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0244 0.1496 0.5148
Trichomonas vaginalis ABC transporter, putative 0.0127 0.073 1
Echinococcus granulosus neuropeptide receptor 0.0019 0.0021 0.0021
Schistosoma mansoni multidrug resistance protein 0.0127 0.073 0.2512
Loa Loa (eye worm) diacylglycerol acyltransferase 0.0125 0.0717 0.2469
Echinococcus granulosus 7tm_1 domain containing protein 0.0019 0.0021 0.0021
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.004 0.0159 0.2175
Echinococcus multilocularis ATP binding cassette sub family B 0.004 0.0159 0.0159
Loa Loa (eye worm) Smad1 0.0024 0.0054 0.0186
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.004 0.0159 0.0478
Echinococcus multilocularis g protein coupled receptor 0.0019 0.0021 0.0021
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0019 0.0021 0.0021
Onchocerca volvulus 0.0021 0.0036 0.021
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.004 0.0159 0.2175
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0021 0.0074
Loa Loa (eye worm) hypothetical protein 0.0055 0.026 0.0893
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0021 0.0074
Loa Loa (eye worm) G-protein coupled receptor 0.0019 0.0021 0.0074
Schistosoma mansoni hypothetical protein 0.0046 0.02 0.0689
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0021 0.0036 0.0036
Echinococcus granulosus neuropeptides capa receptor 0.0019 0.0021 0.0021
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0019 0.0021 0.0021
Entamoeba histolytica hypothetical protein, conserved 0.102 0.6565 1
Trypanosoma cruzi GUP1, putative 0.0021 0.0036 0.0109
Loa Loa (eye worm) MH2 domain-containing protein 0.0349 0.2181 0.7506
Loa Loa (eye worm) hypothetical protein 0.004 0.0159 0.0546
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.005 0.0228 0.0228
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.0074
Schistosoma mansoni neuropeptide receptor 0.0019 0.0021 0.0074
Schistosoma mansoni hypothetical protein 0.0046 0.02 0.0689
Trichomonas vaginalis abcb9, putative 0.0127 0.073 1
Echinococcus granulosus multidrug resistance protein 1 0.0127 0.073 0.073
Brugia malayi hypothetical protein 0.0019 0.0021 0.0074
Schistosoma mansoni ATP-binding cassette sub-family B member 6 mitochondrial precursor (abc6) 0.0038 0.015 0.0515
Entamoeba histolytica hypothetical protein 0.0055 0.026 0.0342
Plasmodium falciparum ABC transporter B family member 3, putative 0.004 0.0159 0.2175
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.0074
Echinococcus granulosus o acyltransferase membrane bound domain 0.0021 0.0036 0.0036
Trypanosoma brucei glycerol uptake protein, putative 0.0021 0.0036 0.0109
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0127 0.073 1
Echinococcus granulosus sex peptide receptor 0.0019 0.0021 0.0021
Schistosoma mansoni biogenic amine (5HT) receptor 0.0019 0.0021 0.0074
Echinococcus granulosus multidrug resistance protein 1 0.0089 0.0479 0.0479
Brugia malayi neuropeptide F receptor 0.0019 0.0021 0.0074
Trichomonas vaginalis sphingomyelin synthetase, putative 0.0055 0.026 0.322
Echinococcus multilocularis G-protein coupled receptor, putative 0.0019 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.004 0.0159 0.0546
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0021 0.0036 0.0125
Loa Loa (eye worm) hypothetical protein 0.0055 0.026 0.0893
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0127 0.073 0.2512
Leishmania major pentamidine resistance protein 1 0.004 0.0159 0.0478
Loa Loa (eye worm) membrane bound O-acyltransferase domain containing 1 0.0021 0.0036 0.0125
Leishmania major glycerol uptake protein, putative 0.0021 0.0036 0.0109
Brugia malayi ABC transporter family protein 0.0127 0.073 0.2512
Wolbachia endosymbiont of Brugia malayi ABC-type multidrug transport system, ATPase and permease component 0.004 0.0159 0.5
Schistosoma mansoni myosin xvIII 0.0019 0.0021 0.0074
Brugia malayi MBOAT family protein 0.0021 0.0036 0.0125
Brugia malayi Latrophilin receptor protein 2 0.0046 0.02 0.0689
Schistosoma mansoni cathepsin D (A01 family) 0.0149 0.0871 0.2997
Mycobacterium leprae PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER 0.004 0.0159 0.5
Echinococcus multilocularis serotonin receptor 0.0019 0.0021 0.0021
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0127 0.073 0.073
Loa Loa (eye worm) ABC transporter 0.004 0.0159 0.0546
Leishmania major glycerol uptake protein, putative 0.0021 0.0036 0.0109
Echinococcus granulosus tachykinin peptides receptor 99D 0.0019 0.0021 0.0021
Leishmania major p-glycoprotein 0.0127 0.073 0.2199
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0127 0.073 1
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0119 0.0674 0.0674
Schistosoma mansoni multidrug resistance protein 0.0127 0.073 0.2512
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0019 0.0021 0.0021
Loa Loa (eye worm) ABC transporter 0.004 0.0159 0.0546
Echinococcus multilocularis G protein coupled receptor 139 0.0019 0.0021 0.0021
Giardia lamblia Multidrug resistance-associated protein 1 0.004 0.0159 0.1577
Echinococcus granulosus neuropeptide Y receptor 0.0019 0.0021 0.0021
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0127 0.073 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.0074
Trichomonas vaginalis abcb9, putative 0.0127 0.073 1
Schistosoma mansoni amine GPCR 0.0019 0.0021 0.0074
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.0074
Echinococcus multilocularis 0.004 0.0159 0.0159
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.0074
Brugia malayi Dopamine receptor 0.0019 0.0021 0.0074
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.0074
Brugia malayi Calcitonin receptor-like protein seb-1 0.0146 0.0852 0.2931
Brugia malayi hypothetical protein 0.0019 0.0021 0.0074
Schistosoma mansoni peptidylglycine monooxygenase 0.0244 0.1496 0.5148
Plasmodium vivax aspartyl proteinase, putative 0.005 0.0228 0.3129
Schistosoma mansoni spingomyelin synthetase-related 0.0055 0.026 0.0893
Brugia malayi ORL1-like opioid receptor 0.0019 0.0021 0.0074
Leishmania major ATP-binding cassette protein subfamily C, member 6, putative 0.004 0.0159 0.0478
Plasmodium vivax ABC transporter B family member 3, putative 0.004 0.0159 0.2175
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.0074
Plasmodium vivax multidrug resistance-associated protein 1, putative 0.004 0.0159 0.2175
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0127 0.073 1
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0127 0.073 0.073
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0021 0.0021
Brugia malayi GnHR receptor homolog 0.0019 0.0021 0.0074
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0019 0.0021 0.0021
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0175 0.1043 0.1043
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 2 0.0055 0.026 0.0893
Echinococcus multilocularis sphingomyelin synthase protein 1 0.0055 0.026 0.026
Toxoplasma gondii ABC transporter family protein 0.004 0.0159 0.2175
Echinococcus multilocularis membrane bound acyltransferase:hhat 0.0021 0.0036 0.0036
Echinococcus granulosus fmrfamide receptor 0.0019 0.0021 0.0021
Plasmodium falciparum ABC transporter B family member 7, putative 0.004 0.0159 0.2175
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0127 0.073 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0021 0.0021
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.004 0.0159 0.2175
Entamoeba histolytica ATP-binding cassette protein, putative 0.004 0.0159 0.0188
Echinococcus multilocularis multidrug resistance protein 1 0.0089 0.0479 0.0479
Brugia malayi hypothetical protein 0.0019 0.0021 0.0074
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.006 0.0182
Schistosoma mansoni ATP-binding cassette sub-family B member 7 mitochondrial precursor (abc7) 0.004 0.0159 0.0546
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.0074
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0019 0.0021 0.0074
Plasmodium vivax multidrug resistance-associated protein 2, putative 0.004 0.0159 0.2175
Trypanosoma brucei ABC transporter, mitochondrial, putative 0.004 0.0159 0.0478
Brugia malayi putative neuropeptide receptor NPR1 0.0019 0.0021 0.0074
Mycobacterium tuberculosis Iron-regulated transporter IrtA 0.004 0.0159 0.2175
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0019 0.0021 0.0074
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.0074
Echinococcus granulosus peptidyl glycine alpha amidating monooxygenase 0.046 0.2906 0.2906
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0019 0.0021 0.0021
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0127 0.073 1
Echinococcus multilocularis g-protein coupled receptor 0.0019 0.0021 0.0021
Leishmania major ATP-binding cassette protein subfamily C, member 5, putative 0.004 0.0159 0.0478
Echinococcus granulosus sphingomyelin synthase protein 1 0.0055 0.026 0.026
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.0074
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0146 0.0852 0.2931
Treponema pallidum alginate O-acetylation protein (algI) 0.0021 0.0036 0.5
Brugia malayi larval opioid receptor 0.0019 0.0021 0.0074
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0019 0.0021 0.0074
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0055 0.026 0.0893
Echinococcus granulosus dro:myosuppressin receptor 0.0019 0.0021 0.0021
Brugia malayi acetyltransferase, GNAT family protein 0.0175 0.1043 0.3589
Brugia malayi Melatonin receptor type 1A 0.0019 0.0021 0.0074
Echinococcus granulosus Smad4 0.0024 0.0054 0.0054
Brugia malayi hypothetical protein 0.0019 0.0021 0.0074
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.0074
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0127 0.073 1
Echinococcus granulosus g-protein coupled receptor 0.0019 0.0021 0.0021
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.026 0.322
Giardia lamblia MRP-like ABC transporter 0.004 0.0159 0.1577
Brugia malayi ABC transporter 0.0038 0.015 0.0515
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0019 0.0021 0.0021
Loa Loa (eye worm) TYRA-2 protein 0.0019 0.0021 0.0074
Brugia malayi MBOAT family protein 0.0021 0.0036 0.0125
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.026 0.0894
Brugia malayi sulfakinin receptor protein 0.0019 0.0021 0.0074
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.0074
Plasmodium falciparum ABC transporter B family member 6, putative 0.004 0.0159 0.2175
Schistosoma mansoni smad 0.0024 0.0054 0.0186
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0021 0.0021
Entamoeba histolytica hypothetical protein 0.0055 0.026 0.0342

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.1413 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference
Potency (functional) = 0.5623 um PUBCHEM_BIOASSAY: qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 4.4668 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.2753 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.3489 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Saccharomyces cerevisiae ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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