Detailed information for compound 1347579

Basic information

Technical information
  • TDR Targets ID: 1347579
  • Name: N-[(Z)-3-(2-dimethylaminoethylamino)-1-[5-(2- nitrophenyl)furan-2-yl]-3-oxoprop-1-en-2-yl]- 4-methylbenzamide
  • MW: 462.498 | Formula: C25H26N4O5
  • H donors: 2 H acceptors: 4 LogP: 3.66 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(CCNC(=O)/C(=C/c1ccc(o1)c1ccccc1[N+](=O)[O-])/NC(=O)c1ccc(cc1)C)C
  • InChi: 1S/C25H26N4O5/c1-17-8-10-18(11-9-17)24(30)27-21(25(31)26-14-15-28(2)3)16-19-12-13-23(34-19)20-6-4-5-7-22(20)29(32)33/h4-13,16H,14-15H2,1-3H3,(H,26,31)(H,27,30)/b21-16-
  • InChiKey: OFKYNOGEHLLOPY-PGMHBOJBSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-[(Z)-1-(2-dimethylaminoethylcarbamoyl)-2-[5-(2-nitrophenyl)-2-furyl]vinyl]-4-methyl-benzamide
  • N-[(Z)-1-[(2-dimethylaminoethylamino)-oxomethyl]-2-[5-(2-nitrophenyl)-2-furyl]vinyl]-4-methylbenzamide
  • N-[(Z)-3-(2-dimethylaminoethylamino)-1-[5-(2-nitrophenyl)furan-2-yl]-3-oxo-prop-1-en-2-yl]-4-methyl-benzamide
  • MLS001163278
  • N-{1-({[2-(dimethylamino)ethyl]amino}carbonyl)-2-[5-(2-nitrophenyl)-2-furyl]vinyl}-4-methylbenzamide
  • SMR000497186

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens microphthalmia-associated transcription factor Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Giardia intestinalis Putative fructose-1,6-bisphosphate aldolase Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Starlite/ChEMBL No references
Schistosoma mansoni Thioredoxin glutathione reductase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133408 All targets in OG5_133408
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Treponema pallidum fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Giardia lamblia Fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Helix-loop-helix DNA-binding domain containing protein Get druggable targets OG5_133408 All targets in OG5_133408
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis transcription factor eb Get druggable targets OG5_133408 All targets in OG5_133408
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein Get druggable targets OG5_133408 All targets in OG5_133408
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus transcription factor eb Get druggable targets OG5_133408 All targets in OG5_133408
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.8 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin reductase 1, cytoplasmic   499 aa 506 aa 23.7 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Plasmodium berghei dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 26.9 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 540 aa 23.3 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.5 %
Leishmania mexicana 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 452 aa 25.7 %
Leishmania infantum acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Leishmania braziliensis dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 488 aa 21.9 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.5 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 539 aa 22.3 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Leishmania braziliensis acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 22.8 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Leishmania donovani acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Trypanosoma brucei dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.4 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.5 %
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Leishmania donovani dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.5 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Leishmania infantum dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 454 aa 25.3 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.6 %
Mycobacterium ulcerans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 26.9 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Neospora caninum hypothetical protein Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 462 aa 25.8 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 518 aa 24.9 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 529 aa 31.8 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Leishmania major acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Plasmodium falciparum thioredoxin reductase Thioredoxin reductase 1, cytoplasmic   499 aa 511 aa 45.2 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 460 aa 25.4 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.3 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Plasmodium falciparum glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 500 aa 32.2 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Leishmania mexicana acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 24.4 %
Neospora caninum glutathione reductase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 32.7 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, point mutation,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.3 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin reductase 1, cytoplasmic   499 aa 464 aa 24.8 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 519 aa 23.7 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Leishmania braziliensis 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 450 aa 25.6 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.2 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.3 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Onchocerca volvulus Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 57.3 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.9 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0008 0.004 0.0113
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0118 0.0331
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0258 0.0724
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0455 0.0802
Onchocerca volvulus 0.0035 0.0579 1
Onchocerca volvulus 0.0009 0.0062 0.0399
Loa Loa (eye worm) MH1 domain-containing protein 0.001 0.0069 0.0194
Loa Loa (eye worm) hypothetical protein 0.0012 0.0118 0.0331
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0008 0.004 0.0046
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0036 0.0598 1
Schistosoma mansoni hypothetical protein 0.0009 0.0062 0.0062
Brugia malayi MH2 domain containing protein 0.0144 0.2825 0.7918
Trichomonas vaginalis mercuric reductase, putative 0.0036 0.0598 0.0804
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.1103 0.309
Echinococcus granulosus thioredoxin glutathione reductase 0.0103 0.1989 0.1989
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.7108 1
Echinococcus multilocularis muscleblind protein 0.018 0.3568 0.3568
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0009 0.0062 0.0062
Giardia lamblia NADH oxidase lateral transfer candidate 0.0036 0.0598 0.0762
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0283 0.0513
Loa Loa (eye worm) hypothetical protein 0.0021 0.0307 0.0859
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0009 0.0062 0.0062
Brugia malayi MH1 domain containing protein 0.001 0.0069 0.0194
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0118 0.0118
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0118 0.0118
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0118 0.0331
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0036 0.0598 0.2883
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.2825 0.7918
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.2825 0.7918
Schistosoma mansoni Smad4 0.001 0.0069 0.0069
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0118 0.0118
Plasmodium falciparum glutathione reductase 0.0103 0.1976 1
Treponema pallidum NADH oxidase 0.0036 0.0598 0.0762
Echinococcus granulosus transcription factor eb 0.013 0.2542 0.2542
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1001 0.1001
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0118 0.0118
Schistosoma mansoni smad1 5 8 and 0.001 0.0069 0.0069
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.1103 0.309
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.1001 0.1001
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0036 0.0598 0.2883
Trypanosoma brucei hypothetical protein, conserved 0.0009 0.0062 0.0111
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0036 0.0598 0.2883
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0008 0.004 0.0113
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0598 0.2883
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0009 0.0062 0.0062
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0118 0.0331
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0036 0.0598 0.2883
Echinococcus granulosus mixed lineage leukemia protein mll 0.0009 0.0044 0.0044
Brugia malayi steroid hormone receptor 0.0012 0.0118 0.0331
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0118 0.0331
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0712 0.1995
Schistosoma mansoni glutamate synthase 0.0009 0.0062 0.0062
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0009 0.0062 0.0111
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0118 0.0118
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.1001 0.2805
Echinococcus granulosus TGF beta signal transducer SmadC 0.001 0.0069 0.0069
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0009 0.0062 0.0062
Brugia malayi nuclear receptor NHR-88 0.0012 0.0118 0.0331
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0258 0.0724
Echinococcus multilocularis muscleblind protein 1 0.018 0.3568 0.3568
Schistosoma mansoni TGF-beta signal transducer Smad2 0.001 0.0069 0.0069
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0009 0.0062 0.0087
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0118 0.0331
Trichomonas vaginalis glutamate synthase, putative 0.0009 0.0062 0.0046
Trypanosoma cruzi NADH dehydrogenase, putative 0.0009 0.0062 0.0111
Echinococcus multilocularis geminin 0.0205 0.4065 0.4065
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0009 0.0062 0.0111
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0118 0.0331
Schistosoma mansoni cpg binding protein 0.0037 0.062 0.062
Trypanosoma cruzi trypanothione reductase, putative 0.0103 0.1976 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0234 0.4677 0.8967
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0455 0.0844
Mycobacterium ulcerans hypothetical protein 0.0029 0.0455 0.1233
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0118 0.0118
Brugia malayi CXXC zinc finger family protein 0.0035 0.0579 0.1623
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0008 0.004 0.0046
Echinococcus multilocularis mothers against decapentaplegic 5 0.001 0.0069 0.0069
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0118 0.0118
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0044 0.0044
Onchocerca volvulus 0.0029 0.0455 0.7697
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0307 0.4563
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0455 0.0587
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0455 0.1275
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0008 0.004 0.0046
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0009 0.0062 0.0064
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.004 0.0113
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0455 0.1233
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0085 0.0238
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0009 0.0062 0.0046
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0009 0.0062 0.0111
Schistosoma mansoni hypothetical protein 0.0494 1 1
Leishmania major hypothetical protein, conserved 0.0009 0.0062 0.0111
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0009 0.0062 0.0064
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0118 0.0118
Echinococcus multilocularis dnaJ subfamily B 0.0494 1 1
Toxoplasma gondii NADPH-glutathione reductase 0.0036 0.0598 0.2883
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1001 0.1001
Schistosoma mansoni hypothetical protein 0.0019 0.0258 0.0258
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0258 0.0258
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0118 0.0331
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0118 0.0118
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0036 0.0598 1
Echinococcus multilocularis cpg binding protein 0.0037 0.062 0.062
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0258 0.0258
Loa Loa (eye worm) glutathione reductase 0.0103 0.1976 0.5538
Trichomonas vaginalis apoptosis inducing factor, putative 0.0009 0.0062 0.0046
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0118 0.0331
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0036 0.0598 0.2883
Loa Loa (eye worm) Smad1 0.001 0.0069 0.0194
Echinococcus multilocularis thioredoxin glutathione reductase 0.0103 0.1989 0.1989
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.7108 1
Loa Loa (eye worm) oxidoreductase 0.0008 0.004 0.0113
Brugia malayi MH1 domain containing protein 0.001 0.0069 0.0194
Brugia malayi Muscleblind-like protein 0.018 0.3568 1
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0009 0.0062 0.0087
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0172 0.3405 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0118 0.0118
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0261 0.5214 1
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0026 0.0404 0.1133
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.0009 0.0062 0.0042
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.1377 0.1377
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0455 0.0587
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0009 0.0062 0.0062
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0118 0.0118
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0307 0.0559
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0036 0.0598 1
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0009 0.0062 0.0046
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0118 0.0118
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.1001 0.1001
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0009 0.0062 0.0111
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0036 0.0598 0.2883
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0009 0.0062 0.0111
Loa Loa (eye worm) hypothetical protein 0.0029 0.0455 0.1275
Schistosoma mansoni smad1 5 8 and 0.001 0.0069 0.0069
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0009 0.0062 0.0064
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0118 0.0331
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0118 0.0331
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1001 0.1001
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.0019 0.0258 0.0724
Toxoplasma gondii selenide, water dikinase 0.0009 0.0062 0.0111
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0036 0.0598 0.2883
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0009 0.0062 0.0087
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0234 0.4677 0.8967
Schistosoma mansoni cpg binding protein 0.0037 0.062 0.062
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0118 0.0118
Trypanosoma brucei NADH dehydrogenase 0.0009 0.0062 0.0111
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0283 0.0513
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.7108 1
Plasmodium falciparum glutathione reductase 0.0036 0.0598 0.2883
Schistosoma mansoni hypothetical protein 0.0019 0.0258 0.0258
Plasmodium vivax glutathione reductase, putative 0.0103 0.1976 1
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0088 0.0246
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0009 0.0062 0.0111
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0009 0.0062 0.0062
Giardia lamblia Fructose-bisphosphate aldolase 0.0353 0.7108 1
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0036 0.0598 0.2883
Schistosoma mansoni hypothetical protein 0.0041 0.0712 0.0712
Plasmodium vivax ferrodoxin reductase, putative 0.0009 0.0062 0.0111
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0009 0.0062 0.0111
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0009 0.0062 0.0064
Brugia malayi Thioredoxin reductase 0.0103 0.1976 0.5538
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0118 0.0331
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0036 0.0598 0.0598
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0009 0.0062 0.0111
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0009 0.0062 0.0046
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0455 0.0844
Schistosoma mansoni hypothetical protein 0.0205 0.4065 0.4065
Brugia malayi AMP-binding enzyme family protein 0.0008 0.004 0.0113
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0283 0.0513
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0009 0.0062 0.0173
Loa Loa (eye worm) thioredoxin reductase 0.0103 0.1976 0.5538
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0008 0.004 0.0046
Echinococcus granulosus cpg binding protein 0.0037 0.062 0.062
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0118 0.0118
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.1001 0.2805
Mycobacterium tuberculosis Probable oxidoreductase 0.0261 0.5214 1
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0118 0.0118
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0118 0.0331
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.0118 0.1446
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0455 0.1275
Brugia malayi nuclear hormone receptor 0.0012 0.0118 0.0331
Trichomonas vaginalis glutamate synthase, putative 0.0009 0.0062 0.0046
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.006 0.1103 0.309
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0044 0.0044
Schistosoma mansoni hypothetical protein 0.0019 0.0258 0.0258
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.7108 1
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0118 0.0118
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0009 0.0062 0.0111
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0118 0.0331
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0118 0.0331
Echinococcus multilocularis GPCR, family 2 0.0019 0.0258 0.0258
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0009 0.0062 0.0064
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0009 0.0062 0.0046
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0118 0.0331
Leishmania major trypanothione reductase 0.0103 0.1976 1
Echinococcus multilocularis glutamate synthase 0.0009 0.0062 0.0062
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0307 0.1376
Trypanosoma cruzi hypothetical protein, conserved 0.0009 0.0062 0.0111
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0009 0.0062 0.0064
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0009 0.0062 0.0062
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.7108 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0455 0.1275
Loa Loa (eye worm) hypothetical protein 0.0008 0.004 0.0113
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0036 0.0598 0.2883
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0118 0.0331
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.7108 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0258 0.0258
Plasmodium vivax thioredoxin reductase, putative 0.0103 0.1976 1
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0455 0.1275
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0455 0.2143
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0455 0.2143
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0118 0.0118
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.0009 0.0062 0.0042
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.1216 0.6071
Mycobacterium tuberculosis Probable reductase 0.0234 0.4677 0.8967
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0118 0.0331
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0598 0.2883
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0009 0.0062 0.0111
Mycobacterium ulcerans ferredoxin reductase 0.0009 0.0062 0.0064
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0008 0.004 0.0046
Entamoeba histolytica thioredoxin reductase, putative 0.0009 0.0062 0.003
Schistosoma mansoni hypothetical protein 0.0019 0.0258 0.0258
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0009 0.0062 0.0111
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0118 0.0331
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0103 0.1976 0.3771
Echinococcus granulosus muscleblind protein 0.018 0.3568 0.3568
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.1001 0.1001
Leishmania major NADH dehydrogenase, putative 0.0009 0.0062 0.0111
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0036 0.0598 0.0598
Loa Loa (eye worm) MH2 domain-containing protein 0.001 0.0069 0.0194
Schistosoma mansoni sulfide quinone reductase 0.0009 0.0062 0.0062
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.0118 0.1446
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0118 0.0331
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0118 0.0118
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0009 0.0062 0.0046
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.0009 0.0062 0.0042
Loa Loa (eye worm) hypothetical protein 0.0021 0.0307 0.0859
Leishmania major hypothetical protein, conserved 0.0009 0.0062 0.0111
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0036 0.0598 0.2883
Brugia malayi ecdysteroid receptor 0.0012 0.0118 0.0331
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.0118 0.1446
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0261 0.5214 1
Trypanosoma brucei trypanothione reductase 0.0103 0.1976 1
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0009 0.0062 0.0046
Brugia malayi AMP-binding enzyme family protein 0.0008 0.004 0.0113
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0044 0.0044
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0307 0.0792
Entamoeba histolytica disulphide oxidoreductase, putative 0.0009 0.0062 0.003
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0036 0.0598 0.112
Loa Loa (eye worm) hypothetical protein 0.0012 0.0118 0.0331
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0455 0.0802
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0009 0.0062 0.0046
Mycobacterium ulcerans glutamate synthase subunit beta 0.0009 0.0062 0.0064
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0008 0.004 0.0046
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0118 0.0331
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.004 0.0046
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0009 0.0062 0.0111
Loa Loa (eye worm) hypothetical protein 0.018 0.3568 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0118 0.0118
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0009 0.0062 0.0111
Schistosoma mansoni hypothetical protein 0.0205 0.4065 0.4065
Schistosoma mansoni cpg binding protein 0.0035 0.0579 0.0579
Schistosoma mansoni glutamate synthase 0.0009 0.0062 0.0062
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0009 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0012 0.0118 0.0331
Brugia malayi MH2 domain containing protein 0.001 0.0069 0.0194
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0009 0.0062 0.003
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0172 0.3405 0.6519
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0009 0.0062 0.0111
Loa Loa (eye worm) hypothetical protein 0.0021 0.0307 0.0859
Loa Loa (eye worm) hypothetical protein 0.0021 0.0307 0.0859
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0283 0.0513
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0009 0.0062 0.0087
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0036 0.0598 0.1677
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0118 0.0331
Trypanosoma cruzi trypanothione reductase, putative 0.0036 0.0598 0.2883
Trypanosoma cruzi hypothetical protein, conserved 0.0009 0.0062 0.0111
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0036 0.0598 0.1659
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0009 0.0062 0.0111
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0036 0.0598 0.2883
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0026 0.0404 0.1133
Onchocerca volvulus 0.0012 0.0118 0.1446
Brugia malayi glutathione reductase 0.0103 0.1976 0.5538
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0118 0.0118
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0036 0.0598 0.1659
Echinococcus granulosus Smad4 0.001 0.0069 0.0069
Mycobacterium ulcerans monoxygenase 0.0009 0.0062 0.0064
Loa Loa (eye worm) hypothetical protein 0.013 0.2529 0.7087
Loa Loa (eye worm) programmed cell death 8 0.0009 0.0062 0.0173
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0036 0.0598 0.2883
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0234 0.4677 0.8967
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0009 0.0062 0.0062
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0172 0.3405 0.6503
Echinococcus multilocularis transcription factor eb 0.013 0.2542 0.2542
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0036 0.0598 0.2883
Echinococcus granulosus geminin 0.0205 0.4065 0.4065
Echinococcus multilocularis Smad4 0.001 0.0069 0.0069
Mycobacterium ulcerans NADH dehydrogenase 0.0009 0.0062 0.0064
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0118 0.0118
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0036 0.0598 0.1659
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0009 0.0062 0.0062
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.7108 1
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0008 0.004 0.0113
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0088 0.0088
Treponema pallidum fructose-bisphosphate aldolase 0.0353 0.7108 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0455 0.1233
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0234 0.4677 0.8963
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0118 0.0118
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0118 0.0118
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0455 0.1233
Loa Loa (eye worm) hypothetical protein 0.0012 0.0118 0.0331
Echinococcus multilocularis smad 0.001 0.0069 0.0069
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0598 0.2883
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0118 0.0118
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0009 0.0062 0.003
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0261 0.5214 1
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0008 0.004 0.004
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0118 0.0331
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.1103 0.309
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0036 0.0598 0.2883
Brugia malayi AMP-binding enzyme family protein 0.0008 0.004 0.0113
Schistosoma mansoni disulfide oxidoreductase 0.0009 0.0062 0.0062
Schistosoma mansoni glutamate synthase 0.0009 0.0062 0.0062
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0009 0.0062 0.003
Loa Loa (eye worm) hypothetical protein 0.0029 0.0455 0.1275
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0009 0.0062 0.0173
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0009 0.0062 0.0042
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0455 0.2143
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0009 0.0062 0.0173
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0455 0.1233
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0009 0.0062 0.0062
Echinococcus granulosus mothers against decapentaplegic 5 0.001 0.0069 0.0069
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0118 0.0331
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0009 0.0062 0.003
Schistosoma mansoni sulfide quinone reductase 0.0009 0.0062 0.0062
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0234 0.4677 0.8967
Mycobacterium ulcerans hypothetical protein 0.0009 0.0062 0.0064
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.004 0.0046
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0009 0.0062 0.0111
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.004 0.0046
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.013 0.2542 0.7123
Plasmodium falciparum thioredoxin reductase 0.0103 0.1976 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0598 0.2883
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0008 0.004 0.0113
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0036 0.0598 0.2883
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.7108 1
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0009 0.0062 0.0111
Mycobacterium tuberculosis Probable dehydrogenase 0.0234 0.4677 0.8967
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0118 0.0118
Echinococcus granulosus smad 0.001 0.0069 0.0069
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0579 0.1623
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0036 0.0598 0.0598
Loa Loa (eye worm) hypothetical protein 0.0041 0.0712 0.1995
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0118 0.0118
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0455 0.0587
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0455 0.1233
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0009 0.0062 0.0046
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.7108 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0258 0.0724
Leishmania major hypothetical protein, conserved 0.0009 0.0062 0.0111
Plasmodium falciparum ferrodoxin reductase-like protein 0.0009 0.0062 0.0111
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.0012 0.0118 0.0331
Brugia malayi MH2 domain containing protein 0.001 0.0069 0.0194
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0009 0.0062 0.0111
Schistosoma mansoni acetyl-CoA synthetase 0.0008 0.004 0.004
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0258 0.0258
Loa Loa (eye worm) hypothetical protein 0.0021 0.0307 0.0859
Plasmodium falciparum thioredoxin reductase 0.0036 0.0598 0.2883
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0009 0.0062 0.0064
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0455 0.1233
Echinococcus granulosus GPCR family 2 0.0019 0.0258 0.0258
Trypanosoma cruzi NADH dehydrogenase, putative 0.0009 0.0062 0.0111
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0009 0.0062 0.003
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0118 0.0118
Trichomonas vaginalis antibiotic synthetase, putative 0.0008 0.004 0.0016
Loa Loa (eye worm) hypothetical protein 0.0012 0.0118 0.0331
Brugia malayi Smad1 0.001 0.0069 0.0194
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0009 0.0062 0.0087
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0118 0.0331
Schistosoma mansoni smad1 5 8 and 0.001 0.0069 0.0069
Echinococcus multilocularis TGF beta signal transducer SmadC 0.001 0.0069 0.0069
Loa Loa (eye worm) hypothetical protein 0.0012 0.0118 0.0331
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0118 0.0118
Toxoplasma gondii thioredoxin reductase 0.0103 0.1976 1
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0009 0.0062 0.0111
Schistosoma mansoni smad 0.001 0.0069 0.0069
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0008 0.004 0.004
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0009 0.0062 0.0087
Brugia malayi glutamate synthase 0.0009 0.0062 0.0173
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0455 0.1233
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.013 0.2529 0.7087
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.1001 0.1001
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0008 0.004 0.0046
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0598 0.2883
Brugia malayi AMP-binding enzyme family protein 0.0008 0.004 0.0113
Loa Loa (eye worm) hypothetical protein 0.0012 0.0118 0.0331
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0009 0.0062 0.0173
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0009 0.0062 0.0062
Trichomonas vaginalis glutathione reductase, putative 0.0036 0.0598 0.0804
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0009 0.0062 0.0046
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0598 0.2883
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.004 0.0046
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0307 0.1376
Mycobacterium ulcerans dehydrogenase 0.0009 0.0062 0.0064
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0009 0.0062 0.0046
Trichomonas vaginalis antibiotic synthetase, putative 0.0008 0.004 0.0016
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0009 0.0062 0.0111
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.7108 1
Echinococcus granulosus glutamate synthase 0.0009 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0009 0.0062 0.0173
Schistosoma mansoni coup transcription factor 0.0012 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.018 0.3568 1
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0009 0.0044 0.0044

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) = 4.871 uM PUBCHEM_BIOASSAY: MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Inhibitor_DoseNoFile_CherryPick_Activity_Set2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488944] ChEMBL. No reference
AC50 (functional) = 4.871 uM PUBCHEM_BIOASSAY: MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Inhibitor_DoseNoFile_CherryPick_Activity_Set4. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488944] ChEMBL. No reference
AC50 (functional) = 4.871 uM PUBCHEM_BIOASSAY: MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Inhibitor_DoseNoFile_CherryPick_Activity_Set3. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488944] ChEMBL. No reference
Potency (functional) 0.5012 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.8913 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 1.4125 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) 1.4716 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 2.9093 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.6964 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 5.0119 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ] ChEMBL. No reference
Potency (functional) = 7.0795 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.691 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 14.1254 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (binding) 17.7828 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.5962 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 112.2018 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.