Detailed information for compound 1371882

Basic information

Technical information
  • TDR Targets ID: 1371882
  • Name: propan-2-yl N-(3-nitrophenyl)sulfonylcarbamat e
  • MW: 288.277 | Formula: C10H12N2O6S
  • H donors: 1 H acceptors: 5 LogP: 1.7 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(OC(=O)NS(=O)(=O)c1cccc(c1)[N+](=O)[O-])C
  • InChi: 1S/C10H12N2O6S/c1-7(2)18-10(13)11-19(16,17)9-5-3-4-8(6-9)12(14)15/h3-7H,1-2H3,(H,11,13)
  • InChiKey: LIPXGISZHNXROP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • isopropyl N-(3-nitrophenyl)sulfonylcarbamate
  • N-(3-nitrophenyl)sulfonylcarbamic acid isopropyl ester
  • MLS000681676
  • SMR000312360
  • isopropyl (3-nitrophenyl)sulfonylcarbamate

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0037 0.011 0.0172
Onchocerca volvulus 0.0025 0.004 0.0069
Loa Loa (eye worm) TK/ROR protein kinase 0.0023 0.0026 0.004
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0006 0.0038
Echinococcus multilocularis musashi 0.0081 0.0366 0.0366
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0056 0.0218 0.5275
Echinococcus multilocularis ecdysone induced protein 78C 0.0028 0.0052 0.0052
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.0022 0.0019 0.0037
Brugia malayi Zona pellucida-like domain containing protein 0.0032 0.0077 0.0147
Echinococcus granulosus thioredoxin glutathione reductase 0.0089 0.0415 0.0415
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0135 0.0826
Brugia malayi von Willebrand factor type A domain containing protein 0.0032 0.0077 0.0147
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0038 0.0116 0.0875
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0061 0.0248 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.011 0.0172
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.011 0.0541 0.0541
Onchocerca volvulus 0.005 0.0183 0.0321
Echinococcus multilocularis beta adrenergic receptor kinase 0.0037 0.011 0.011
Schistosoma mansoni tyrosine kinase 0.0138 0.0705 0.1261
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0299 0.1825
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0038 0.0116 0.0116
Mycobacterium tuberculosis Probable oxidoreductase 0.0224 0.1215 0.8934
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0025 0.004 0.0241
Schistosoma mansoni hypothetical protein 0.0114 0.056 0.1003
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0037 0.011 0.0172
Loa Loa (eye worm) hypothetical protein 0.0138 0.0705 0.11
Echinococcus granulosus axis inhibition protein axin 0.0037 0.011 0.011
Brugia malayi glutathione reductase 0.0088 0.0412 0.0786
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0031 0.0071 0.0431
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0025 0.004 0.0916
Echinococcus granulosus glutamate NMDA receptor subunit 0.0228 0.1238 0.1238
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0053 0.0205 0.0205
Echinococcus granulosus leukotriene A 4 hydrolase 0.0363 0.2035 0.2035
Loa Loa (eye worm) hypothetical protein 0.0481 0.2734 0.427
Echinococcus granulosus nmda type glutamate receptor 0.0256 0.1401 0.1401
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0028 0.0052 0.0052
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0028 0.0052 0.01
Echinococcus multilocularis neutral amino acid transporter A 0.0249 0.1359 0.1359
Loa Loa (eye worm) hypothetical protein 0.0032 0.0077 0.0121
Brugia malayi metabotropic glutamate receptor type 2 0.0472 0.2676 0.5102
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0243 0.1325 0.9745
Schistosoma mansoni hypothetical protein 0.0138 0.0703 0.1258
Schistosoma mansoni glutamate receptor NMDA 0.0228 0.1238 0.2215
Loa Loa (eye worm) aminopeptidase N 0.0025 0.004 0.0062
Loa Loa (eye worm) cytochrome P450 family protein 0.0075 0.0331 0.0516
Brugia malayi Regulator of G protein signaling domain containing protein 0.0037 0.011 0.021
Echinococcus multilocularis neutral amino acid transporter A 0.0249 0.1359 0.1359
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0125 0.0628 0.1123
Schistosoma mansoni lamin 0.0081 0.0366 0.0656
Echinococcus multilocularis slit 2 protein 0.0023 0.0028 0.0028
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0081 0.0366 0.0572
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0028 0.0052 0.01
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0183 0.0328
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0216 0.0216
Leishmania major cathepsin L-like protease 0.0069 0.0299 0.1825
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0037 0.011 0.0172
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0363 0.2035 0.2035
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0006 0.0006
Echinococcus multilocularis sodium:dicarboxylate symporter 0.011 0.0541 0.0541
Brugia malayi von Willebrand factor type A domain containing protein 0.0032 0.0077 0.0147
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0216 0.0386
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0299 0.1825
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0216 0.0386
Brugia malayi hypothetical protein 0.0025 0.004 0.0075
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0028 0.0052 0.0094
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0031 0.0071 0.0135
Toxoplasma gondii 6-phosphofructokinase 0.0061 0.0248 0.1874
Brugia malayi Protein kinase domain containing protein 0.0023 0.0026 0.0049
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0025 0.004 0.0071
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0216 0.0216
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0031 0.0071 0.1118
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0249 0.1359 0.1359
Echinococcus multilocularis dna polymerase kappa 0.002 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0028 0.0052 0.0082
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0031 0.0071 0.0475
Loa Loa (eye worm) hypothetical protein 0.0019 0.0002 0.0003
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0041 0.0133 0.2109
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0044 0.0149 0.0911
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0028 0.0052 0.0052
Schistosoma mansoni RAR-like nuclear receptor 0.0028 0.0052 0.0094
Schistosoma mansoni hypothetical protein 0.0023 0.0026 0.0046
Schistosoma mansoni glutamate receptor kainate 0.0228 0.1238 0.2215
Loa Loa (eye worm) hypothetical protein 0.0039 0.012 0.0187
Schistosoma mansoni aminopeptidase A (M01 family) 0.0025 0.004 0.0071
Brugia malayi Bloom's syndrome protein homolog 0.0066 0.0277 0.0528
Echinococcus granulosus excitatory amino acid transporter 2 0.0249 0.1359 0.1359
Leishmania major extracellular receptor, putative 0.0138 0.0705 0.43
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0002 0.0002
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0006 0.0006
Onchocerca volvulus 0.0023 0.0026 0.0045
Brugia malayi Peptidase family M1 containing protein 0.0025 0.004 0.0075
Loa Loa (eye worm) hypothetical protein 0.0028 0.0052 0.0082
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0518 0.2951 0.2951
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0031 0.0071 0.0431
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0202 0.1082 0.795
Plasmodium vivax von Willebrand factor A domain-related protein, putative 0.0032 0.0077 0.1223
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0225 0.1218 0.3991
Loa Loa (eye worm) hypothetical protein 0.0038 0.0116 0.0181
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0032 0.0076 0.0461
Echinococcus granulosus lamin dm0 0.0081 0.0366 0.0366
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0028 0.0052 0.01
Schistosoma mansoni regulator of G protein signaling 0.0037 0.011 0.0197
Echinococcus multilocularis aminopeptidase N 0.0025 0.004 0.004
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0224 0.1215 0.8934
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0028 0.0052 0.0094
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0224 0.1215 0.8934
Echinococcus granulosus transcription factor Dp 1 0.0042 0.0136 0.0136
Brugia malayi follicle stimulating hormone receptor 0.0487 0.2764 0.5271
Schistosoma mansoni lipoxygenase 0.0019 0.0002 0.0003
Loa Loa (eye worm) CUTiclin family member 0.0032 0.0077 0.0121
Loa Loa (eye worm) hypothetical protein 0.0032 0.0077 0.0121
Echinococcus multilocularis bloom syndrome protein 0.0066 0.0277 0.0277
Mycobacterium tuberculosis Conserved hypothetical protein 0.0156 0.0811 0.5947
Loa Loa (eye worm) CUTiclin-Like family member 0.0032 0.0077 0.0121
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0264 0.0473
Onchocerca volvulus 0.0047 0.0169 0.0295
Plasmodium falciparum thioredoxin reductase 0.0088 0.0412 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0243 0.1325 1
Trypanosoma cruzi extracellular receptor, putative 0.0138 0.0705 0.43
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0114 0.056 0.056
Trypanosoma cruzi cysteine peptidase, putative 0.0069 0.0299 0.1825
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0135 0.0826
Loa Loa (eye worm) hypothetical protein 0.0138 0.0705 0.11
Trichomonas vaginalis mercuric reductase, putative 0.0031 0.0071 0.0123
Loa Loa (eye worm) hypothetical protein 0.0032 0.0077 0.0121
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0072 0.0315 0.06
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0746 0.43 0.7696
Treponema pallidum 76K protein 0.0032 0.0077 0.0238
Brugia malayi hypothetical protein 0.0019 0.0002 0.0004
Chlamydia trachomatis neutral amino acid transporter 0.011 0.0541 0.365
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0028 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0138 0.0705 0.11
Schistosoma mansoni axis inhibition protein axin 0.0037 0.011 0.0197
Loa Loa (eye worm) hypothetical protein 0.0022 0.0019 0.003
Plasmodium vivax circumsporozoite- and TRAP-related protein, putative 0.0032 0.0077 0.1223
Loa Loa (eye worm) 6-phosphofructokinase 0.0225 0.1218 0.1902
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.0022 0.0019 0.0099
Brugia malayi von Willebrand factor type A domain containing protein 0.0032 0.0077 0.0147
Entamoeba histolytica hypothetical protein 0.0036 0.0103 0.0849
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0006 0.0011
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0138 0.0705 0.1231
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0032 0.0077 0.0135
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0248 0.1357 0.1357
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0031 0.0071 0.0488
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0072 0.0315 0.1922
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0216 0.0216
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0142 0.073 0.5117
Trypanosoma cruzi aminopeptidase, putative 0.0025 0.004 0.0241
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0225 0.1218 0.7431
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0061 0.0248 0.2039
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0104 0.0505 0.0904
Plasmodium falciparum circumsporozoite- and TRAP-related protein 0.0032 0.0077 0.1833
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0072 0.0315 0.0564
Onchocerca volvulus 0.0028 0.0052 0.0091
Toxoplasma gondii microneme protein MIC2 0.0032 0.0077 0.0582
Trichomonas vaginalis phosphofructokinase, putative 0.0061 0.0248 0.0434
Schistosoma mansoni serine-rich repeat protein 0.0402 0.2264 0.4052
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0039 0.091
Brugia malayi Peptidase family M1 containing protein 0.0025 0.004 0.0075
Loa Loa (eye worm) hypothetical protein 0.0023 0.0028 0.0043
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0038 0.0116 0.0116
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0061 0.0248 0.6004
Echinococcus granulosus bloom syndrome protein 0.0066 0.0277 0.0277
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0228 0.1238 0.1238
Loa Loa (eye worm) hypothetical protein 0.0028 0.0052 0.0082
Schistosoma mansoni hypothetical protein 0.0032 0.0077 0.0138
Brugia malayi Pre-SET motif family protein 0.0867 0.5015 0.9562
Schistosoma mansoni survival motor neuron protein 0.0047 0.0169 0.0303
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0006 0.0038
Onchocerca volvulus 0.0032 0.0077 0.0135
Entamoeba histolytica hypothetical protein 0.0036 0.0103 0.0849
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0038 0.0116 0.0221
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0076 0.0461
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0039 0.0297
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0028 0.0052 0.0082
Trichomonas vaginalis ap endonuclease, putative 0.0056 0.0218 0.0382
Schistosoma mansoni tyrosine kinase 0.0138 0.0705 0.1261
Plasmodium vivax 6-phosphofructokinase, putative 0.0061 0.0248 0.3951
Loa Loa (eye worm) hypothetical protein 0.0079 0.0358 0.0559
Loa Loa (eye worm) von Willebrand factor type A domain-containing protein 0.0032 0.0077 0.0121
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0084 0.0383 0.3038
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0025 0.004 0.0241
Giardia lamblia NADH oxidase lateral transfer candidate 0.0031 0.0071 0.2842
Schistosoma mansoni 6-phosphofructokinase 0.0225 0.1218 0.2179
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0028 0.0052 0.0082
Echinococcus granulosus dna polymerase kappa 0.002 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0037 0.0111 0.0173
Brugia malayi TATA binding protein associated factor 0.0025 0.004 0.0075
Plasmodium vivax glutathione reductase, putative 0.0088 0.0412 0.6564
Brugia malayi 6-phosphofructokinase 0.0225 0.1218 0.2322
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0363 0.2035 0.3641
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0299 0.1825
Schistosoma mansoni glutamate receptor kainate 0.038 0.2136 0.3823
Brugia malayi A-kinase anchor protein 10, precursor 0.0037 0.011 0.021
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0104 0.0104
Schistosoma mansoni 6-phosphofructokinase 0.0225 0.1218 0.2179
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0006 0.0038
Loa Loa (eye worm) hypothetical protein 0.0037 0.011 0.0172
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0029 0.0059 0.0105
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0053 0.0205 0.0205
Leishmania major trypanothione reductase 0.0088 0.0412 0.2515
Loa Loa (eye worm) hypothetical protein 0.0028 0.0052 0.0082
Schistosoma mansoni cpg binding protein 0.0029 0.0063 0.0112
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.006 0.0244 0.5895
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0276 0.1518 0.2371
Echinococcus granulosus tyrosine kinase 0.0138 0.0705 0.0705
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0088 0.0412 0.3
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0002 0.0002
Schistosoma mansoni loxhd1 0.0019 0.0002 0.0003
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0031 0.0071 0.0431
Loa Loa (eye worm) hypothetical protein 0.0023 0.0028 0.0043
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0038 0.0116 0.0875
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0225 0.1218 0.8954
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0032 0.0076 0.0621
Leishmania major hypothetical protein, conserved 0.0023 0.0026 0.0156
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0006 0.0012
Echinococcus granulosus glutamate receptor 2 0.0253 0.1382 0.1382
Plasmodium falciparum thioredoxin reductase 0.0031 0.0071 0.1672
Onchocerca volvulus Protein ultraspiracle homolog 0.0028 0.0052 0.0091
Entamoeba histolytica phosphofructokinase, putative 0.0225 0.1218 1
Loa Loa (eye worm) peptidase family M1 containing protein 0.0025 0.004 0.0062
Brugia malayi hypothetical protein 0.0037 0.011 0.021
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.011 0.0541 0.0968
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0518 0.2951 0.2951
Loa Loa (eye worm) TATA binding protein associated factor 0.0025 0.004 0.0062
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0025 0.004 0.0241
Loa Loa (eye worm) hypothetical protein 0.0028 0.0052 0.0082
Echinococcus granulosus neurogenic locus notch protein 0.0023 0.0028 0.0028
Trypanosoma cruzi trypanothione reductase, putative 0.0088 0.0412 0.2515
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0114 0.056 0.056
Loa Loa (eye worm) phosphofructokinase 0.0225 0.1218 0.1902
Loa Loa (eye worm) hypothetical protein 0.0032 0.0077 0.0121
Loa Loa (eye worm) hypothetical protein 0.0037 0.0111 0.0173
Schistosoma mansoni thyroid hormone receptor 0.0276 0.152 0.272
Schistosoma mansoni regulator of G protein signaling 0.0037 0.011 0.0197
Onchocerca volvulus 0.0019 0.0002 0.0003
Trypanosoma brucei unspecified product 0.002 0.0006 0.0038
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0243 0.1325 0.1325
Plasmodium vivax dynein-related AAA-type ATPase, putative 0.0032 0.0077 0.1223
Onchocerca volvulus 0.0028 0.0053 0.0093
Echinococcus multilocularis RUN 0.0019 0.0002 0.0002
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0025 0.004 0.004
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0056 0.0218 0.0218
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0363 0.2035 0.3178
Loa Loa (eye worm) hypothetical protein 0.0344 0.1925 0.3007
Loa Loa (eye worm) hypothetical protein 0.0028 0.0052 0.0082
Loa Loa (eye worm) hypothetical protein 0.0138 0.0705 0.11
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0072 0.0315 0.0492
Echinococcus multilocularis neurogenic locus notch protein 0.0023 0.0028 0.0028
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.011 0.0192
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0006 0.0038
Trichomonas vaginalis phosphofructokinase, putative 0.0225 0.1218 0.2128
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0031 0.0071 0.0431
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0028 0.0052 0.01
Chlamydia trachomatis glutamate symporter 0.0249 0.1359 1
Brugia malayi Glutamate receptor 1 precursor 0.0228 0.1238 0.236
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0028 0.0052 0.0082
Giardia lamblia Sgs1 DNA helicase, putative 0.0038 0.0116 0.4668
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0104 0.0104
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0028 0.0052 0.01
Brugia malayi hypothetical protein 0.022 0.1189 0.2267
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0296 0.1639 1
Brugia malayi laminin-like protein K08C7.3 precursor 0.0023 0.0028 0.0053
Brugia malayi ecdysteroid receptor 0.0028 0.0052 0.01
Loa Loa (eye worm) hypothetical protein 0.0032 0.0077 0.0121
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0028 0.0052 0.0082
Schistosoma mansoni axis inhibition protein axin 0.0037 0.011 0.0197
Echinococcus granulosus pikachurin 0.0023 0.0028 0.0028
Schistosoma mansoni lamin 0.0081 0.0366 0.0656
Echinococcus granulosus regulator of G protein signaling 3 0.0037 0.011 0.011
Brugia malayi Receptor family ligand binding region containing protein 0.0276 0.1518 0.2894
Echinococcus multilocularis receptor type guanylyl cyclase 0.0138 0.0705 0.0705
Entamoeba histolytica hypothetical protein 0.0138 0.0705 0.5786
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0031 0.0071 0.0431
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0028 0.0052 0.0052
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0005 0.003
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0028 0.0052 0.0094
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0964 0.5588 1
Trichomonas vaginalis phosphofructokinase, putative 0.0061 0.0248 0.0434
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0028 0.0052 0.0052
Plasmodium falciparum von Willebrand factor A domain-related protein 0.0032 0.0077 0.1833
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0299 0.1825
Onchocerca volvulus 0.0032 0.0077 0.0135
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0125 0.0628 0.1123
Echinococcus granulosus neutral amino acid transporter A 0.0249 0.1359 0.1359
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0006 0.0051
Loa Loa (eye worm) hypothetical protein 0.0032 0.0077 0.0121
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0044 0.0149 0.0911
Brugia malayi Peptidase family M1 containing protein 0.0025 0.004 0.0075
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0104 0.0633
Loa Loa (eye worm) hypothetical protein 0.0081 0.0366 0.0572
Schistosoma mansoni hypothetical protein 0.0164 0.0857 0.1533
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0031 0.0071 0.0431
Plasmodium vivax thrombospondin-related anonymous protein 0.0032 0.0077 0.1223
Onchocerca volvulus Bile acid receptor homolog 0.0028 0.0052 0.0091
Loa Loa (eye worm) 6-phosphofructokinase 0.0225 0.1218 0.1902
Entamoeba histolytica hypothetical protein 0.0037 0.011 0.0903
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0025 0.004 0.004
Echinococcus multilocularis regulator of G protein signaling 7 0.0037 0.011 0.011
Trichomonas vaginalis rotamase, putative 0.0032 0.008 0.014
Trypanosoma cruzi Aminopeptidase M1, putative 0.0025 0.004 0.0241
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0276 0.1518 0.2371
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0867 0.5015 0.7833
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0025 0.004 0.004
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.004 0.0128 0.0969
Trypanosoma cruzi cysteine peptidase, putative 0.0069 0.0299 0.1825
Brugia malayi hypothetical protein 0.0037 0.011 0.021
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0056 0.0218 0.8796
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0006 0.0038
Echinococcus granulosus Excitatory amino acid transporter 0.0249 0.1359 0.1359
Onchocerca volvulus Metabotropic glutamate receptor homolog 0.0138 0.0703 0.1228
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0028 0.0052 0.0094
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0025 0.004 0.004
Echinococcus granulosus regulator of G protein signaling 7 0.0037 0.011 0.011
Loa Loa (eye worm) PXA domain-containing protein 0.0037 0.011 0.0172
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0169 0.0322
Echinococcus granulosus beta-adrenergic receptor kinase 0.0037 0.011 0.011
Trichomonas vaginalis DNA helicase recq, putative 0.0066 0.0277 0.0484
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0039 0.012 0.012
Loa Loa (eye worm) excitatory amino acid transporter 0.0249 0.1359 0.2123
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0036 0.0104 0.0198
Echinococcus multilocularis axis inhibition protein axin 0.0037 0.011 0.011
Echinococcus multilocularis regulator of G protein signaling 7 0.0037 0.011 0.011
Schistosoma mansoni regulator of G protein signaling 0.0037 0.011 0.0197
Schistosoma mansoni hypothetical protein 0.0032 0.0077 0.0138
Schistosoma mansoni cell polarity protein 0.0023 0.0028 0.005
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0076 0.0461
Onchocerca volvulus 0.0138 0.0705 0.1231
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0061 0.0248 0.6004
Loa Loa (eye worm) hypothetical protein 0.0025 0.004 0.0062
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0299 0.1825
Schistosoma mansoni DNA polymerase eta 0.002 0.0006 0.0011
Entamoeba histolytica hypothetical protein, conserved 0.0032 0.0077 0.0634
Schistosoma mansoni hypothetical protein 0.0047 0.0169 0.0303
Wolbachia endosymbiont of Brugia malayi Na+/H+-dicarboxylate symporter 0.0249 0.1359 1
Brugia malayi Thioredoxin reductase 0.0088 0.0412 0.0786
Schistosoma mansoni metabotropic glutamate receptor 0.0472 0.2676 0.4789
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0084 0.0383 0.9299
Schistosoma mansoni glutamate receptor NMDA 0.0366 0.2053 0.3674
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0125 0.0628 0.4738
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0072 0.0315 0.0315
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0031 0.0071 0.0431
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0039 0.024
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0084 0.0383 0.6106
Loa Loa (eye worm) RGC/RGC protein kinase 0.0138 0.0705 0.11
Echinococcus granulosus metabotropic glutamate receptor 5 0.1102 0.6403 0.6403
Loa Loa (eye worm) hypothetical protein 0.0481 0.2734 0.427
Loa Loa (eye worm) glutamate receptor 0.0334 0.1861 0.2906
Echinococcus granulosus tissue type plasminogen activator 0.0023 0.0026 0.0026
Brugia malayi PXA domain containing protein 0.0037 0.011 0.021
Trichomonas vaginalis phosphofructokinase, putative 0.0061 0.0248 0.0434
Entamoeba histolytica elongation factor-2 kinase, putative 0.0032 0.0077 0.0634
Entamoeba histolytica hypothetical protein 0.0036 0.0103 0.0849
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0025 0.004 0.004
Mycobacterium ulcerans epimerase 0.0022 0.0019 0.0099
Brugia malayi Excitatory amino acid transporter 0.0249 0.1359 0.2592
Echinococcus granulosus lamin 0.0081 0.0366 0.0366
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0006 0.0038
Echinococcus multilocularis dna polymerase eta 0.002 0.0006 0.0006
Plasmodium falciparum glutathione reductase 0.0031 0.0071 0.1672
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0299 0.1825
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0031 0.0071 0.0071
Onchocerca volvulus Poor gastrulation protein homolog 0.0138 0.0703 0.1228
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0037 0.011 0.0197
Toxoplasma gondii thioredoxin reductase 0.0088 0.0412 0.3111
Plasmodium falciparum cysteine repeat modular protein 1 0.0023 0.0026 0.0577
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0028 0.0052 0.01
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0028 0.0052 0.01
Echinococcus granulosus dnaJ subfamily B 0.0395 0.2224 0.2224
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.004
Mycobacterium tuberculosis Probable C4-dicarboxylate-transport transmembrane protein DctA 0.0249 0.1359 1
Brugia malayi hypothetical protein 0.0032 0.0077 0.0147
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0031 0.0071 0.0488
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0063 0.0264 0.1608
Echinococcus multilocularis regulator of G protein signaling 3 0.0037 0.011 0.011
Trichomonas vaginalis phosphofructokinase, putative 0.0225 0.1218 0.2128
Echinococcus multilocularis lamin 0.0081 0.0366 0.0366
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0002 0.0003
Onchocerca volvulus 0.0032 0.0077 0.0135
Schistosoma mansoni glutamate receptor AMPA 0.0228 0.1238 0.2215
Schistosoma mansoni lipoxygenase 0.0053 0.0205 0.0366
Brugia malayi Guanylyl cyclase protein 23 0.0138 0.0705 0.1343
Echinococcus granulosus survival motor neuron protein 1 0.0232 0.126 0.126
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0006 0.0038
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0366 0.2053 0.2053
Brugia malayi von Willebrand factor type A domain containing protein 0.0032 0.0077 0.0147
Brugia malayi Receptor family ligand binding region containing protein 0.0138 0.0705 0.1343
Entamoeba histolytica phosphofructokinase, putative 0.0225 0.1218 1
Echinococcus multilocularis GPCR, family 3, C terminal 0.0138 0.0703 0.0703
Onchocerca volvulus 0.0032 0.0077 0.0135
Treponema pallidum hypothetical protein 0.0032 0.0077 0.0238
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0031 0.0071 0.1672
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0025 0.004 0.0069
Leishmania major DNA polymerase kappa, putative 0.002 0.0006 0.0038
Toxoplasma gondii hypothetical protein 0.0048 0.0172 0.1295
Echinococcus multilocularis neutral amino acid transporter A 0.0249 0.1359 0.1359
Echinococcus multilocularis thioredoxin glutathione reductase 0.0089 0.0415 0.0415
Loa Loa (eye worm) glutamate receptor 2 0.0228 0.1238 0.1933
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0104 0.0181
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0025 0.004 0.0241
Echinococcus granulosus expressed protein 0.0032 0.008 0.008
Brugia malayi hypothetical protein 0.0138 0.0705 0.1343
Onchocerca volvulus 0.0125 0.0628 0.1097
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0104 0.0505 0.0505
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0031 0.0071 0.0126
Trichomonas vaginalis phosphofructokinase, putative 0.0225 0.1218 0.2128
Schistosoma mansoni z-protein (S1r protein) 0.0037 0.011 0.0197
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0028 0.0052 0.0094
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0039 0.0619
Echinococcus multilocularis cpg binding protein 0.0029 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.0025 0.0039 0.0061
Mycobacterium ulcerans hypothetical protein 0.0156 0.0811 0.6102
Echinococcus granulosus excitatory amino acid transporter 3 0.0249 0.1359 0.1359
Echinococcus granulosus regulator of G protein signaling 3 0.0037 0.011 0.011
Entamoeba histolytica hypothetical protein 0.0037 0.011 0.0903
Echinococcus granulosus atrial natriuretic peptide receptor 0.0138 0.0705 0.0705
Onchocerca volvulus 0.0032 0.0077 0.0135
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0216 0.0411
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0031 0.0071 0.0431
Schistosoma mansoni cpg binding protein 0.0028 0.0053 0.0095
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0216 0.0337
Entamoeba histolytica hypothetical protein 0.0032 0.0077 0.0634
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0008
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0028 0.0052 0.0052
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0299 0.1825
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0142 0.073 0.5349
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.014 0.0717 0.4377
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0044 0.0149 0.0911
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0037 0.011 0.0172
Loa Loa (eye worm) hypothetical protein 0.0023 0.0028 0.0043
Echinococcus multilocularis regulator of G protein signaling 0.0037 0.011 0.011
Echinococcus multilocularis expressed protein 0.0727 0.4184 0.4184
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0056 0.0218 0.1147
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0056 0.0218 0.3474
Schistosoma mansoni chondroitin sulfate proteoglycan-related 0.0023 0.0028 0.005
Trichomonas vaginalis rotamase, putative 0.0032 0.0076 0.0132
Echinococcus granulosus geminin 0.0164 0.0857 0.0857
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0006 0.0038
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0104 0.0181
Echinococcus granulosus collagen alpha 1VII chain 0.0032 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0047 0.0166 0.0259
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0025 0.004 0.004
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0025 0.004 0.004
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0006 0.0038
Brugia malayi PXA domain containing protein 0.0037 0.011 0.021
Loa Loa (eye worm) hypothetical protein 0.002 0.0006 0.001
Echinococcus granulosus RUN 0.0019 0.0002 0.0002
Brugia malayi Regulator of G protein signaling domain containing protein 0.0037 0.011 0.021
Loa Loa (eye worm) hypothetical protein 0.0125 0.0628 0.098
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0037 0.011 0.0197
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0028 0.0052 0.0052
Echinococcus granulosus glutamate receptor subunit protein glur 0.0114 0.056 0.056
Echinococcus multilocularis 6 phosphofructokinase 0.0225 0.1218 0.1218
Schistosoma mansoni serine/threonine protein kinase 0.0037 0.011 0.0197
Loa Loa (eye worm) hypothetical protein 0.0276 0.1518 0.2371
Schistosoma mansoni serine/threonine protein kinase 0.0037 0.011 0.0197
Schistosoma mansoni lozenge 0.006 0.0246 0.0441
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0202 0.1082 0.795
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0023 0.0022 0.0043
Echinococcus granulosus expressed protein 0.0727 0.4184 0.4184
Echinococcus granulosus nmda type glutamate receptor 0.0138 0.0705 0.0705
Schistosoma mansoni DNA helicase recq1 0.0038 0.0116 0.0207
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0028 0.0052 0.0052
Treponema pallidum glutamate/aspartate transporter 0.011 0.0541 0.1764
Loa Loa (eye worm) RecQ helicase 0.0066 0.0277 0.0433
Echinococcus multilocularis tyrosine kinase 0.0138 0.0705 0.0705
Schistosoma mansoni rotamase 0.0032 0.008 0.0143
Brugia malayi Pre-SET motif family protein 0.0125 0.0628 0.1197
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0025 0.004 0.0241
Echinococcus granulosus excitatory amino acid transporter 2 0.0249 0.1359 0.1359
Mycobacterium ulcerans 6-phosphofructokinase 0.0225 0.1218 0.9189
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0025 0.004 0.004
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0032 0.0076 0.0461
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.014 0.0717 0.4377
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0142 0.073 0.5489
Onchocerca volvulus 0.0081 0.0366 0.064
Plasmodium vivax SET domain protein, putative 0.0125 0.0628 1
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0031 0.0071 0.0431
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0125 0.0628 0.0628
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0036 0.0104 0.0186
Loa Loa (eye worm) steroid hormone receptor 0.0028 0.0052 0.0082
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0299 0.1825
Mycobacterium ulcerans aldehyde dehydrogenase 0.0243 0.1325 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0031 0.0071 0.1672
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0025 0.004 0.004
Brugia malayi Steroid receptor seven-up type 2 0.0028 0.0052 0.01
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0072 0.0315 0.1922
Trypanosoma brucei Aminopeptidase M1, putative 0.0025 0.004 0.0241
Loa Loa (eye worm) glutamate receptor 1 0.0228 0.1238 0.1933
Echinococcus granulosus neutral amino acid transporter A 0.0249 0.1359 0.1359
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0202 0.1082 0.8867
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0025 0.004 0.0069
Brugia malayi Nuclear hormone receptor-like 1 0.0028 0.0052 0.01
Loa Loa (eye worm) thioredoxin reductase 0.0088 0.0412 0.0644
Toxoplasma gondii NADPH-glutathione reductase 0.0031 0.0071 0.0533
Echinococcus granulosus neutral amino acid transporter 0.0249 0.1359 0.1359
Brugia malayi von Willebrand factor type A domain containing protein 0.0032 0.0077 0.0147
Plasmodium falciparum glutathione reductase 0.0088 0.0412 1
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0783 0.4519 0.4519
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0061 0.0248 0.1379
Trichomonas vaginalis phosphofructokinase, putative 0.0061 0.0248 0.0434
Mycobacterium tuberculosis Conserved hypothetical protein 0.0022 0.0019 0.0097
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0266 0.1459 0.1459
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0025 0.004 0.0241
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0006 0.0038
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0266 0.1459 0.1459
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0072 0.0315 0.0315
Echinococcus multilocularis pikachurin 0.0023 0.0028 0.0028
Treponema pallidum methyl-accepting chemotaxis protein (mcp2-1) 0.0534 0.3044 1
Echinococcus multilocularis Excitatory amino acid transporter 0.0249 0.1359 0.1359
Echinococcus granulosus Excitatory amino acid transporter 0.0249 0.1359 0.1359
Echinococcus multilocularis dnaJ subfamily B 0.0395 0.2224 0.2224
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0025 0.004 0.0241
Leishmania major hypothetical protein, conserved 0.0025 0.0039 0.024
Brugia malayi hypothetical protein 0.0232 0.126 0.2403
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0299 0.1825
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0138 0.0705 0.11
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0056 0.0218 0.1609
Trypanosoma brucei Aminopeptidase M1, putative 0.0025 0.004 0.0241
Loa Loa (eye worm) hypothetical protein 0.0104 0.0505 0.0788
Schistosoma mansoni polycystin 1-related 0.0019 0.0002 0.0003
Toxoplasma gondii aldehyde dehydrogenase 0.0243 0.1325 1
Brugia malayi Cytochrome P450 family protein 0.0075 0.0331 0.063
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0225 0.1218 0.7431
Schistosoma mansoni solute carrier family 1 (glial high affinity glutamate transporter 0.0249 0.1359 0.2433
Schistosoma mansoni nuclear hormone receptor 0.0028 0.0052 0.0094
Schistosoma mansoni hypothetical protein 0.0164 0.0857 0.1533
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0038 0.0116 0.2777
Plasmodium vivax multidomain scavenger receptor, putative 0.0019 0.0002 0.0024
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0104 0.0104
Mycobacterium tuberculosis Probable dehydrogenase 0.0202 0.1082 0.795
Schistosoma mansoni serine/threonine protein kinase 0.0037 0.011 0.0197
Brugia malayi von Willebrand Factor 0.0032 0.0077 0.0147
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0296 0.1639 1
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0006 0.0011
Brugia malayi Cache domain containing protein 0.0344 0.1925 0.367
Trichomonas vaginalis phosphofructokinase, putative 0.0225 0.1218 0.2128
Brugia malayi phosphofructokinase 0.0225 0.1218 0.2322
Brugia malayi EGF-like domain containing protein 0.0023 0.0028 0.0053
Leishmania major cathepsin L-like protease 0.0069 0.0299 0.1825
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0036 0.0104 0.0852
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0227 0.1714
Brugia malayi Thrombospondin N-terminal -like domain containing protein 0.0023 0.0028 0.0053
Echinococcus granulosus FTZ F1 alpha 0.0028 0.0052 0.0052
Schistosoma mansoni blooms syndrome DNA helicase 0.0046 0.0162 0.0289
Echinococcus multilocularis ubiquitin specific protease 41 0.0036 0.0104 0.0104
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0202 0.1082 0.795
Entamoeba histolytica hypothetical protein 0.0036 0.0103 0.0849
Trichomonas vaginalis ap endonuclease, putative 0.0056 0.0218 0.0382
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0189 0.1154
Schistosoma mansoni cpg binding protein 0.0029 0.0063 0.0112
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0025 0.004 0.0241
Echinococcus granulosus histone lysine methyltransferase setb 0.0125 0.0628 0.0628
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.0022 0.0019 0.0034
Loa Loa (eye worm) hypothetical protein 0.0032 0.0077 0.0121
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0056 0.0218 0.1333
Schistosoma mansoni DNA helicase recq5 0.0038 0.0116 0.0207
Onchocerca volvulus 0.0987 0.5723 1
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0038 0.0116 0.0181
Echinococcus multilocularis glutamate receptor 2 0.0253 0.1382 0.1382
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0005 0.003
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0104 0.0505 0.0505
Loa Loa (eye worm) hypothetical protein 0.0036 0.0104 0.0162
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0037 0.011 0.0192
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0028 0.0052 0.0082
Echinococcus granulosus ecdysone induced protein 78C 0.0028 0.0052 0.0052
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0039 0.024
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0103 0.0103
Schistosoma mansoni laminin gamma-3 chain 0.0023 0.0028 0.005
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0006 0.0038
Brugia malayi nuclear hormone receptor 0.0028 0.0052 0.01
Echinococcus multilocularis collagen alpha 1(VII) chain 0.0032 0.0077 0.0077
Schistosoma mansoni hypothetical protein 0.0019 0.0002 0.0003
Echinococcus multilocularis regulator of G protein signaling 3 0.0037 0.011 0.011
Entamoeba histolytica aminopeptidase, putative 0.0025 0.004 0.0325
Trichomonas vaginalis glutathione reductase, putative 0.0031 0.0071 0.0123
Brugia malayi 6-phosphofructokinase 0.0225 0.1218 0.2322
Brugia malayi hypothetical protein 0.0019 0.0002 0.0004
Echinococcus multilocularis voltage dependent calcium channel subunit 0.0778 0.4488 0.4488
Brugia malayi intermediate filament protein 0.0081 0.0366 0.0699
Echinococcus multilocularis excitatory amino acid transporter 2 0.0249 0.1359 0.1359
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0056 0.0218 0.1333
Echinococcus granulosus tumor protein p63 0.034 0.1899 0.1899
Plasmodium vivax 6-phosphofructokinase, putative 0.0061 0.0248 0.3951
Brugia malayi regulator of G-protein signaling egl-10 0.0037 0.011 0.021
Brugia malayi Immunoglobulin I-set domain containing protein 0.0032 0.0077 0.0147
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0028 0.0052 0.0052
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0518 0.2951 0.2951
Echinococcus multilocularis geminin 0.0164 0.0857 0.0857
Schistosoma mansoni thyroid hormone receptor 0.0276 0.152 0.272
Schistosoma mansoni regulator of G protein signaling 0.0037 0.011 0.0197
Loa Loa (eye worm) hypothetical protein 0.0664 0.3813 0.5956
Schistosoma mansoni aldehyde dehydrogenase 0.0243 0.1325 0.2371
Loa Loa (eye worm) hypothetical protein 0.0084 0.0383 0.0599
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0061 0.0248 0.1379
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0002 0.0002
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0061 0.0248 0.0801
Toxoplasma gondii peptidylprolyl isomerase 0.0032 0.0076 0.0571
Brugia malayi von Willebrand factor type A domain containing protein 0.0032 0.0077 0.0147
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0006 0.0038
Echinococcus granulosus aminopeptidase N 0.0025 0.004 0.004
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0038 0.0116 0.0116
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0036 0.0104 0.0633
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0072 0.0315 0.1922
Schistosoma mansoni glutamate receptor AMPA 0.0228 0.1238 0.2215
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0028 0.0052 0.0082
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0037 0.011 0.011
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0006 0.001
Echinococcus multilocularis metabotropic glutamate receptor 5 0.1102 0.6403 0.6403
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0138 0.0703 0.134
Schistosoma mansoni regulator of G protein signaling 0.0037 0.011 0.0197
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0023 0.0022 0.0043
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0032 0.008 0.0153
Trichomonas vaginalis set domain proteins, putative 0.0987 0.5723 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0006 0.0038
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0006 0.0038
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0043 0.0145 0.0226
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0028 0.0052 0.0052
Onchocerca volvulus 0.0481 0.2734 0.4777
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0038 0.0116 0.0221
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0028 0.0052 0.0052
Echinococcus granulosus regulator of G protein signaling 7 0.0037 0.011 0.011
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0028 0.0052 0.0091
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0039 0.091
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0039 0.012 0.012
Brugia malayi von Willebrand factor type A domain containing protein 0.0032 0.0077 0.0147
Treponema pallidum NADH oxidase 0.0031 0.0071 0.0216
Echinococcus multilocularis tumor protein p63 0.034 0.1899 0.1899
Toxoplasma gondii phosphofructokinase PFKII 0.0061 0.0248 0.1874
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0243 0.1325 0.1325
Trypanosoma cruzi cruzipain precursor, putative 0.0069 0.0299 0.1825
Toxoplasma gondii aminopeptidase N protein 0.0025 0.004 0.0299
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0366 0.2053 0.2053
Brugia malayi hypothetical protein 0.0025 0.0039 0.0075
Brugia malayi hypothetical protein 0.0025 0.004 0.0075
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0056 0.0218 0.1333
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0104 0.0505 0.0904
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0487 0.2764 0.4317
Brugia malayi von Willebrand factor type A domain containing protein 0.0032 0.0077 0.0147
Loa Loa (eye worm) hypothetical protein 0.0037 0.011 0.0172
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0028 0.0052 0.01
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0038 0.0116 0.0116
Loa Loa (eye worm) hypothetical protein 0.0032 0.0077 0.0121
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0031 0.0071 0.0533
Trypanosoma cruzi aminopeptidase, putative 0.0025 0.004 0.0241
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0026 0.0156
Loa Loa (eye worm) RGC/RGC protein kinase 0.0138 0.0705 0.11
Entamoeba histolytica phosphofructokinase, putative 0.0225 0.1218 1
Toxoplasma gondii von Willebrand factor type A domain-containing protein 0.0032 0.0077 0.0582
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0028 0.0052 0.0082
Echinococcus multilocularis tissue type plasminogen activator 0.0023 0.0026 0.0026
Trypanosoma cruzi cysteine peptidase, putative 0.0069 0.0299 0.1825
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.011 0.0192
Echinococcus multilocularis nmda type glutamate receptor 0.0138 0.0705 0.0705
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0224 0.1215 0.9977
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0056 0.0218 0.1568
Loa Loa (eye worm) hypothetical protein 0.0138 0.0705 0.11
Loa Loa (eye worm) hypothetical protein 0.0037 0.011 0.0172
Brugia malayi cytoplasmic intermediate filament protein 0.0043 0.0145 0.0276
Echinococcus multilocularis excitatory amino acid transporter 2 0.0249 0.1359 0.1359
Loa Loa (eye worm) hypothetical protein 0.0025 0.004 0.0062
Brugia malayi nuclear receptor NHR-88 0.0028 0.0052 0.01
Echinococcus granulosus cpg binding protein 0.0029 0.0063 0.0063
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0769 0.4431 0.4431
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0028 0.0052 0.01
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0104 0.0181
Echinococcus granulosus receptor type guanylyl cyclase 0.0138 0.0705 0.0705
Toxoplasma gondii aminopeptidase N, putative 0.0025 0.004 0.0299
Entamoeba histolytica hypothetical protein 0.0037 0.011 0.0903
Brugia malayi hypothetical protein 0.0036 0.0103 0.0197
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0002 0.0002
Loa Loa (eye worm) intermediate filament protein 0.0081 0.0366 0.0572
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0031 0.0071 0.0431
Toxoplasma gondii endonuclease IV APN 0.0084 0.0383 0.2894
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0028 0.0052 0.01
Echinococcus multilocularis thyroid hormone receptor alpha 0.0276 0.152 0.152
Brugia malayi laminin alpha chain 0.0023 0.0028 0.0053
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0518 0.2951 0.2951
Onchocerca volvulus 0.0019 0.0002 0.0003
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0104 0.0104
Trypanosoma cruzi trypanothione reductase, putative 0.0031 0.0071 0.0431
Echinococcus granulosus 6 phosphofructokinase 0.0225 0.1218 0.1218
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0031 0.0071 0.1118
Loa Loa (eye worm) hypothetical protein 0.005 0.0183 0.0287
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0037 0.011 0.011
Giardia lamblia DINP protein human, muc B family 0.002 0.0006 0.0251
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0006 0.0038
Echinococcus granulosus slit 2 protein 0.0023 0.0028 0.0028
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0768 0.443 0.8446
Schistosoma mansoni hypothetical protein 0.0248 0.1357 0.2428
Plasmodium vivax thioredoxin reductase, putative 0.0088 0.0412 0.6564
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.011 0.0192
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0025 0.004 0.0069
Loa Loa (eye worm) RGS-3 protein 0.0037 0.011 0.0172
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0036 0.0104 0.4181
Echinococcus granulosus metabotropic glutamate receptor 2 0.0769 0.4431 0.4431
Brugia malayi photoreceptor-specific nuclear receptor 0.0028 0.0052 0.01
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0376 0.2113 0.3781
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0104 0.0505 0.0904
Loa Loa (eye worm) hypothetical protein 0.0232 0.126 0.1969
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0002 0.0002
Brugia malayi Zona pellucida-like domain containing protein 0.0032 0.0077 0.0147
Onchocerca volvulus Excitatory amino acid transporter homolog 0.0249 0.1359 0.2375
Mycobacterium ulcerans hypothetical protein 0.0022 0.0019 0.0099
Plasmodium vivax hypothetical protein, conserved 0.0032 0.0077 0.1223
Echinococcus granulosus intermediate filament protein 0.0081 0.0366 0.0366
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0299 0.1825
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0028 0.0052 0.01
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0061 0.0248 0.1874
Schistosoma mansoni ap endonuclease 0.0056 0.0218 0.0391
Loa Loa (eye worm) hypothetical protein 0.0104 0.0505 0.0788
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0084 0.0383 0.0731
Schistosoma mansoni rab6-interacting 0.0019 0.0002 0.0003
Echinococcus multilocularis NMDA receptor 0.0266 0.1459 0.1459
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0031 0.0071 0.0488
Echinococcus multilocularis Regulator of G protein signaling 20 0.0037 0.011 0.011
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0135 0.0826
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0056 0.0218 0.1333
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0031 0.0071 0.0431
Echinococcus granulosus glutamate receptor 2 0.0366 0.2053 0.2053
Loa Loa (eye worm) hypothetical protein 0.1102 0.6403 1
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0023 0.0026 0.0401
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0025 0.004 0.0623
Trichomonas vaginalis DNA helicase recq, putative 0.0044 0.0149 0.0261
Schistosoma mansoni steroid hormone receptor ad4bp 0.0028 0.0052 0.0094
Schistosoma mansoni coup transcription factor 0.0028 0.0052 0.0094
Echinococcus multilocularis transcription factor Dp 1 0.0042 0.0136 0.0136
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0028 0.0052 0.0052
Onchocerca volvulus 0.0081 0.0366 0.064
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0103 0.0185
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0142 0.073 0.2386
Onchocerca volvulus 0.0138 0.0705 0.1231
Trichomonas vaginalis phosphofructokinase, putative 0.0061 0.0248 0.0434
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0125 0.0628 0.1123
Echinococcus granulosus voltage dependent calcium channel subunit 0.0778 0.4488 0.4488
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0025 0.004 0.0623
Echinococcus multilocularis Excitatory amino acid transporter 0.0249 0.1359 0.1359
Echinococcus granulosus sodium:dicarboxylate symporter 0.0249 0.1359 0.1359
Mycobacterium ulcerans aldehyde dehydrogenase 0.0243 0.1325 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0006 0.0038
Schistosoma mansoni ATP-binding cassette transporter 0.0228 0.1238 0.2215
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.011 0.0192
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0031 0.0071 0.0431
Echinococcus granulosus GPCR family 3 C terminal 0.0138 0.0703 0.0703
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.011 0.0192
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0135 0.0826
Brugia malayi hypothetical protein 0.0481 0.2734 0.5213
Loa Loa (eye worm) hypothetical protein 0.0019 0.0002 0.0003
Schistosoma mansoni glutamate receptor kainate 0.038 0.2136 0.3823
Loa Loa (eye worm) hypothetical protein 0.0032 0.0077 0.0121
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0299 0.1825
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0056 0.0218 0.0218
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0031 0.0071 0.0071
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0006 0.0011
Schistosoma mansoni ap endonuclease 0.0056 0.0218 0.0391
Schistosoma mansoni retinoic acid receptor RXR 0.0028 0.0052 0.0094
Mycobacterium ulcerans aminopeptidase N PepN 0.0025 0.004 0.0253
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0032 0.0077 0.0147
Schistosoma mansoni slit 0.0023 0.0028 0.005
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0104 0.0633
Entamoeba histolytica recQ family helicase, putative 0.0019 0 0.0004
Entamoeba histolytica hypothetical protein, conserved 0.0032 0.0077 0.0634
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0296 0.1639 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0216 0.0386
Schistosoma mansoni hypothetical protein 0.0036 0.0103 0.0185
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0025 0.004 0.004
Brugia malayi steroid hormone receptor 0.0028 0.0052 0.01
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.008 0.014
Brugia malayi CXXC zinc finger family protein 0.0028 0.0053 0.0102
Echinococcus granulosus ubiquitin specific protease 41 0.0036 0.0104 0.0104
Echinococcus granulosus dna polymerase eta 0.002 0.0006 0.0006
Echinococcus multilocularis expressed protein 0.0032 0.008 0.008
Plasmodium falciparum thrombospondin-related anonymous protein 0.0032 0.0077 0.1833
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0006 0.0038
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0032 0.008 0.0125
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0138 0.0705 0.1343
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0036 0.0104 0.0186
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0103 0.0103
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0138 0.0705 0.0705
Echinococcus multilocularis lamin dm0 0.0081 0.0366 0.0366
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0006 0.0012
Brugia malayi Kringle domain containing protein 0.0023 0.0026 0.0049
Schistosoma mansoni rab6-interacting 0.0019 0.0002 0.0003
Treponema pallidum exodeoxyribonuclease (exoA) 0.0056 0.0218 0.0703
Loa Loa (eye worm) hypothetical protein 0.0032 0.0077 0.0121
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0006 0.0038
Toxoplasma gondii kringle domain-containing protein 0.0023 0.0026 0.0193
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0216 0.0216
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0028 0.0052 0.0094
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0061 0.0248 0.0434
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0039 0.024
Trichomonas vaginalis phosphofructokinase, putative 0.0061 0.0248 0.0434
Mycobacterium ulcerans endonuclease IV 0.0084 0.0383 0.2861
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0084 0.0383 0.2788
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0028 0.0052 0.01
Toxoplasma gondii exonuclease III APE 0.0056 0.0218 0.1648
Loa Loa (eye worm) hypothetical protein 0.0138 0.0705 0.11
Loa Loa (eye worm) von Willebrand factor domain-containing protein 0.0032 0.0077 0.0121
Echinococcus granulosus axis inhibition protein axin 0.0037 0.011 0.011
Loa Loa (eye worm) abnormal epIthelia family member 0.0023 0.0028 0.0043
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0006 0.0038
Echinococcus multilocularis FTZ F1 alpha 0.0028 0.0052 0.0052
Brugia malayi Glutamate receptor 2 precursor 0.0228 0.1238 0.236
Echinococcus granulosus Regulator of G protein signaling 20 0.0037 0.011 0.011
Loa Loa (eye worm) RGC/RGC protein kinase 0.0138 0.0705 0.11
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0028 0.0052 0.01
Trypanosoma brucei trypanothione reductase 0.0088 0.0412 0.2515
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.012 0.0597 0.0597
Loa Loa (eye worm) glutathione reductase 0.0088 0.0412 0.0644
Loa Loa (eye worm) hypothetical protein 0.0028 0.0052 0.0082
Onchocerca volvulus 0.0032 0.0077 0.0135
Brugia malayi Metabotropic glutamate receptor precursor. 0.0906 0.5245 1
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0025 0.004 0.0071
Schistosoma mansoni protein kinase 0.0138 0.0705 0.1261
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0025 0.004 0.0916
Brugia malayi regulator of G-protein signaling rgs-7 0.0037 0.011 0.021
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0518 0.2951 0.2951
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0031 0.0071 0.0431
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0031 0.0071 0.0431
Mycobacterium ulcerans aminopeptidase N PepN 0.0025 0.004 0.0253
Leishmania major cathepsin L-like protease 0.0069 0.0299 0.1825
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.011 0.0192
Echinococcus multilocularis nmda type glutamate receptor 0.0256 0.1401 0.1401
Toxoplasma gondii aminopeptidase n, putative 0.0025 0.004 0.0299
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0053 0.0083
Entamoeba histolytica recQ family helicase, putative 0.0044 0.0149 0.1225
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.014 0.0717 0.4377
Trypanosoma cruzi major cysteine proteinase, putative 0.0054 0.0211 0.129
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0025 0.004 0.0241
Echinococcus multilocularis voltage dependent calcium channel subunit 0.1711 1 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0077 0.0121
Onchocerca volvulus 0.0032 0.0077 0.0135
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0031 0.0071 0.0431
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0002 0.0002
Echinococcus multilocularis glutamate receptor 2 0.0366 0.2053 0.2053
Loa Loa (eye worm) runx1 0.006 0.0246 0.0385
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0005 0.0037
Loa Loa (eye worm) hypothetical protein 0.0032 0.0077 0.0121
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0518 0.2951 0.2951
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0037 0.011 0.0197
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.011 0.0541 0.0968
Chlamydia trachomatis endonuclease IV 0.0084 0.0383 0.2428
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0243 0.1325 0.8084
Schistosoma mansoni blooms syndrome DNA helicase 0.002 0.0005 0.0009
Onchocerca volvulus 0.0025 0.004 0.0069
Loa Loa (eye worm) hypothetical protein 0.0025 0.004 0.0062
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0072 0.0315 0.1922
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0225 0.1218 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0056 0.0218 0.1793
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0125 0.0628 0.1123
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0025 0.004 0.0241
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0056 0.0218 0.0341
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0031 0.0071 0.0431
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0249 0.1359 0.1359
Echinococcus multilocularis excitatory amino acid transporter 3 0.0249 0.1359 0.1359
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0006 0.0011
Schistosoma mansoni metabotropic glutamate receptor 0.0769 0.4431 0.7931
Loa Loa (eye worm) glutamate receptor 0.0906 0.5245 0.8191
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0037 0.011 0.021
Leishmania major DNA polymerase eta, putative 0.002 0.0006 0.0038
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0202 0.1082 0.795
Brugia malayi hypothetical protein 0.0255 0.1395 0.266
Loa Loa (eye worm) hypothetical protein 0.0032 0.0077 0.0121
Entamoeba histolytica recQ family DNA helicase 0.002 0.0005 0.004
Schistosoma mansoni hypothetical protein 0.0402 0.2264 0.4052
Loa Loa (eye worm) hypothetical protein 0.0138 0.0705 0.11
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0125 0.0628 0.0628
Brugia malayi Intermediate filament tail domain containing protein 0.0081 0.0366 0.0699
Onchocerca volvulus 0.0025 0.004 0.0069
Echinococcus multilocularis axis inhibition protein axin 0.0037 0.011 0.011
Schistosoma mansoni intermediate filament proteins 0.0081 0.0366 0.0656
Chlamydia trachomatis glutamine binding protein 0.0142 0.073 0.5117
Echinococcus multilocularis survival motor neuron protein 1 0.0232 0.126 0.126
Loa Loa (eye worm) hypothetical protein 0.0032 0.0077 0.0121
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0028 0.0052 0.0052
Trichomonas vaginalis DNA helicase recq1, putative 0.0066 0.0277 0.0484
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0408 0.2299 0.2299
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0248 0.1357 0.1357
Brugia malayi exodeoxyribonuclease III family protein 0.0056 0.0218 0.0416
Echinococcus multilocularis glutamate receptor 2 0.0228 0.1238 0.1238
Echinococcus multilocularis Protein lozenge 0.006 0.0246 0.0246
Brugia malayi Doublecortin family protein 0.0019 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0037 0.011 0.0172
Mycobacterium tuberculosis Probable reductase 0.0202 0.1082 0.795
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0006 0.0038
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0114 0.056 0.056
Schistosoma mansoni aldehyde dehydrogenase 0.0243 0.1325 0.2371
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0142 0.073 0.2386
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0104 0.0633
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0025 0.004 0.004
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0266 0.1459 0.1459
Schistosoma mansoni hypothetical protein 0.0395 0.2224 0.3981
Trypanosoma brucei aminopeptidase, putative 0.0025 0.004 0.0241
Leishmania major mitochondrial DNA polymerase beta 0.0296 0.1639 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0052 0.0082
Loa Loa (eye worm) hypothetical protein 0.0138 0.0703 0.1098
Treponema pallidum glutamate transporter 0.011 0.0541 0.1764
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0025 0.004 0.004
Leishmania major ATP-dependent phosphofructokinase 0.0225 0.1218 0.7431
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0072 0.0315 0.2586

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 10 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.5113 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (binding) 25.1189 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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