Detailed information for compound 1382426

Basic information

Technical information
  • TDR Targets ID: 1382426
  • Name: 6-chloro-7-methyl-4-oxo-N-[4-(1,3-thiazol-2-y lsulfamoyl)phenyl]chromene-2-carboxamide
  • MW: 475.925 | Formula: C20H14ClN3O5S2
  • H donors: 2 H acceptors: 5 LogP: 3.47 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1cc(=O)c2c(o1)cc(c(c2)Cl)C)Nc1ccc(cc1)S(=O)(=O)Nc1nccs1
  • InChi: 1S/C20H14ClN3O5S2/c1-11-8-17-14(9-15(11)21)16(25)10-18(29-17)19(26)23-12-2-4-13(5-3-12)31(27,28)24-20-22-6-7-30-20/h2-10H,1H3,(H,22,24)(H,23,26)
  • InChiKey: WPEMTRPPZFOWFY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6-chloro-7-methyl-4-oxo-N-[4-(thiazol-2-ylsulfamoyl)phenyl]chromene-2-carboxamide
  • 6-chloro-7-methyl-4-oxo-N-[4-(2-thiazolylsulfamoyl)phenyl]-2-chromenecarboxamide
  • 6-chloro-4-keto-7-methyl-N-[4-(thiazol-2-ylsulfamoyl)phenyl]chromene-2-carboxamide
  • ZINC02331829
  • 6-Chloro-7-methyl-4-oxo-4H-chromene-2-carboxylic acid [4-(thiazol-2-ylsulfamoyl)-phenyl]-amide
  • MLS000332032
  • SMR000221509
  • STOCK5S-50010

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens polymerase (DNA directed), eta Starlite/ChEMBL No references
Equus caballus Ferritin light chain Starlite/ChEMBL No references
Homo sapiens phosphatidylinositol-5-phosphate 4-kinase, type II, alpha Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed), beta Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Leishmania braziliensis mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II Get druggable targets OG5_131617 All targets in OG5_131617
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Echinococcus multilocularis phosphatidylinositol 5 phosphate 4 kinase type 2 Get druggable targets OG5_131617 All targets in OG5_131617
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Toxoplasma gondii ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma mansoni DNA polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Cryptosporidium parvum DinB/family X-type DNA polymerase Get druggable targets OG5_128521 All targets in OG5_128521
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Trypanosoma congolense mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania mexicana DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei gambiense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus granulosus phosphatidylinositol 5 phosphate 4 kinase type 2 Get druggable targets OG5_131617 All targets in OG5_131617
Loa Loa (eye worm) pip kinase 2 Get druggable targets OG5_131617 All targets in OG5_131617
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Trypanosoma brucei gambiense mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131617 All targets in OG5_131617
Neospora caninum Pc21g17280 protein, related Get druggable targets OG5_128521 All targets in OG5_128521
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania mexicana mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Trypanosoma brucei mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Brugia malayi ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania infantum mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Echinococcus granulosus dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania major mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128521 All targets in OG5_128521
Mycobacterium tuberculosis Conserved hypothetical protein Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania mexicana Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus multilocularis dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Leishmania donovani mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Trypanosoma congolense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Onchocerca volvulus Get druggable targets OG5_131617 All targets in OG5_131617
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II Get druggable targets OG5_131617 All targets in OG5_131617
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma japonicum ko:K00889 1-phosphatidylinositol-4-phosphate 5-kinase [EC2.7.1.68], putative Get druggable targets OG5_131617 All targets in OG5_131617
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Brugia malayi Pip kinase protein 2 Get druggable targets OG5_131617 All targets in OG5_131617
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 142 aa 29.6 %
Echinococcus granulosus expressed protein Ferritin light chain   175 aa 146 aa 28.8 %
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative polymerase (DNA directed), beta 335 aa 303 aa 32.3 %
Trypanosoma brucei phosphatidylinositol phosphate kinase alpha phosphatidylinositol-5-phosphate 4-kinase, type II, alpha 406 aa 341 aa 32.0 %
Schistosoma japonicum Ferritin, putative Ferritin light chain   175 aa 144 aa 24.3 %
Echinococcus multilocularis expressed protein Ferritin light chain   175 aa 146 aa 30.1 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 43.9 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 44.4 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 146 aa 28.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni tyrosine kinase 0.0047 0.0279 0.0326
Echinococcus granulosus apoptotic protease activating factor 1 0.0089 0.0718 0.0798
Schistosoma mansoni inositol monophosphatase 0.0041 0.0213 0.0249
Onchocerca volvulus 0.0099 0.0821 0.159
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0064 0.045 0.0484
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0067 0.0486 0.0463
Echinococcus multilocularis lamin 0.0028 0.0079 0.0048
Leishmania major alpha glucosidase II subunit, putative 0.0038 0.018 0.0368
Loa Loa (eye worm) hypothetical protein 0.0096 0.0787 0.0764
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0033 0.013 0.0372
Trypanosoma brucei unspecified product 0.0046 0.0267 0.0546
Schistosoma mansoni aldehyde dehydrogenase 0.0124 0.1085 0.1269
Toxoplasma gondii thioredoxin reductase 0.0047 0.0281 0.0713
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0096 0.0787 0.124
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.0916 0.1479
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0025 0.004 0.0258
Echinococcus granulosus insulin receptor 0.0047 0.0279 0.0283
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0075 0.0571 0.1452
Loa Loa (eye worm) hypothetical protein 0.004 0.0202 0.0179
Trypanosoma cruzi cytochrome P450, putative 0.0036 0.0158 0.0323
Brugia malayi RNA binding protein 0.0073 0.0554 0.1091
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.0281 0.0907
Echinococcus multilocularis apoptotic protease activating factor 1 0.0089 0.0718 0.0798
Schistosoma mansoni jumonji/arid domain-containing protein 0.0283 0.2763 0.323
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.045 0.0526
Mycobacterium ulcerans carbon monoxyde dehydrogenase small chain CoxS 0.0035 0.0146 0.0491
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0079 0.0055
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0067 0.0486 0.0526
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0075 0.0574 0.063
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0075 0.0574 0.063
Trypanosoma brucei RNA helicase, putative 0.0101 0.0848 0.1731
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0096 0.0787 0.124
Mycobacterium tuberculosis Conserved protein 0.004 0.0202 0.063
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0213 0.0435
Onchocerca volvulus 0.0098 0.0817 0.1582
Echinococcus multilocularis neuropeptide s receptor 0.0517 0.5228 0.6095
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0049 0.0296 0.0302
Brugia malayi mbt repeat family protein 0.0048 0.0285 0.0539
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0041 0.0213 0.0716
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0025 0.004 0.0082
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0169 0.1558 0.2523
Echinococcus multilocularis caspase 3 0.0157 0.1434 0.1639
Trichomonas vaginalis esterase, putative 0.004 0.0202 0.0269
Brugia malayi Furin-like cysteine rich region family protein 0.0148 0.1339 0.27
Trypanosoma brucei unspecified product 0.0046 0.0267 0.0546
Brugia malayi Importin beta-1 subunit 0.0033 0.0133 0.0228
Mycobacterium tuberculosis Probable carbon monoxyde dehydrogenase (small chain) 0.0035 0.0146 0.0431
Trypanosoma brucei Metacaspase-4 0.0096 0.0787 0.1606
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0281 0.0284
Schistosoma mansoni 6-phosphofructokinase 0.0108 0.0916 0.1071
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0026 0.006 0.0026
Schistosoma mansoni terminal deoxycytidyl transferase 0.0067 0.0486 0.0568
Schistosoma mansoni aryl hydrocarbon receptor 0.0051 0.0318 0.0372
Plasmodium falciparum phosphoglycerate kinase 0.0169 0.1558 0.3964
Schistosoma mansoni alpha glucosidase 0.0038 0.018 0.0211
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0129 0.1137 0.129
Trichomonas vaginalis sucrase-isomaltase, putative 0.0038 0.018 0.0232
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0171 0.0217
Loa Loa (eye worm) mbt repeat family protein 0.0048 0.0285 0.0261
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.003 0.0094 0.011
Echinococcus multilocularis lamin dm0 0.0028 0.0079 0.0048
Onchocerca volvulus 0.004 0.0205 0.036
Plasmodium vivax metacaspase 1, putative 0.0096 0.0787 0.5048
Echinococcus multilocularis neutral alpha glucosidase AB 0.0038 0.018 0.0167
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.013 0.0265
Onchocerca volvulus 0.0028 0.0079 0.0108
Echinococcus multilocularis phd:f box containing protein 0.0075 0.0571 0.0626
Schistosoma mansoni loxhd1 0.004 0.0205 0.0239
Trichomonas vaginalis conserved hypothetical protein 0.0096 0.0787 0.124
Echinococcus multilocularis importin subunit beta 1 0.0033 0.0133 0.0111
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.0202 0.0193
Loa Loa (eye worm) hypothetical protein 0.004 0.0202 0.0179
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0129 0.1137 0.2322
Loa Loa (eye worm) TK/EGFR protein kinase 0.0148 0.1339 0.1318
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0108 0.092 0.3172
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0175 0.1622 0.186
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0049 0.0296 0.0603
Loa Loa (eye worm) hypothetical protein 0.004 0.0202 0.0179
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.013 0.0148
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0075 0.0574 0.063
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0031 0.0103 0.012
Echinococcus granulosus microtubule associated protein 2 0.0833 0.8554 1
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0075 0.0574 0.063
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0037 0.0168 0.0508
Onchocerca volvulus Alhambra homolog 0.0031 0.0103 0.0157
Mycobacterium leprae Probable pyruvate kinase PykA 0.0033 0.013 0.0372
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0146 0.0122
Onchocerca volvulus 0.0439 0.4406 0.8749
Trypanosoma brucei carbonic anhydrase-like protein 0.0486 0.4897 1
Echinococcus granulosus lysine specific demethylase 5A 0.0283 0.2763 0.32
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0104 0.0876 0.0854
Brugia malayi Thioredoxin reductase 0.0047 0.0281 0.053
Echinococcus multilocularis caspase 0.0253 0.244 0.282
Loa Loa (eye worm) hypothetical protein 0.0075 0.0571 0.0548
Plasmodium vivax importin-beta 2, putative 0.0033 0.0133 0.0855
Loa Loa (eye worm) hypothetical protein 0.0033 0.013 0.0106
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.004 0.0202 0.063
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0291 0.2847 1
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0108 0.0916 0.146
Plasmodium falciparum metacaspase-like protein 0.0096 0.0787 0.2001
Trypanosoma cruzi DNA polymerase eta, putative 0.0052 0.0324 0.0661
Echinococcus granulosus histone lysine methyltransferase setb 0.0064 0.045 0.0484
Brugia malayi Pre-SET motif family protein 0.0438 0.4396 0.8973
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0062 0.0434 0.0886
Brugia malayi hypothetical protein 0.0035 0.0151 0.0264
Echinococcus multilocularis muscleblind protein 0.0166 0.1528 0.175
Entamoeba histolytica deoxycytidyl transferase, putative 0.0067 0.0486 0.0765
Echinococcus granulosus importin subunit beta 1 0.0033 0.0133 0.0111
Loa Loa (eye worm) hypothetical protein 0.0171 0.1582 0.1561
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0196 0.1848 0.216
Mycobacterium tuberculosis Probable esterase LipL 0.004 0.0202 0.063
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0064 0.045 0.0526
Echinococcus granulosus single minded 2 0.0038 0.0179 0.0165
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.021 0.1993 0.2295
Echinococcus multilocularis Polycystic kidney disease protein 0.004 0.0205 0.0195
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0104 0.0874 0.0982
Loa Loa (eye worm) hypothetical protein 0.0026 0.006 0.0036
Plasmodium vivax SET domain protein, putative 0.0064 0.045 0.2888
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0075 0.0571 0.1166
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.0171 0.0348
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0041 0.0213 0.0287
Echinococcus granulosus jumonji domain containing protein 0.0043 0.0229 0.0224
Loa Loa (eye worm) CYP4Cod1 0.0036 0.0158 0.0134
Trichomonas vaginalis conserved hypothetical protein 0.0096 0.0787 0.124
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0169 0.1558 0.5434
Mycobacterium ulcerans phosphoglycerate kinase 0.0169 0.1558 0.5233
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0171 0.1579 0.1558
Trypanosoma cruzi DNA polymerase eta, putative 0.0098 0.081 0.1653
Treponema pallidum phosphoglycerate kinase 0.0169 0.1558 0.2527
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0088 0.0079
Schistosoma mansoni single-minded 0.0051 0.0318 0.0372
Onchocerca volvulus 0.0064 0.045 0.085
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0171 0.0217
Loa Loa (eye worm) jmjC domain-containing protein 0.0075 0.0571 0.0548
Trypanosoma brucei DNA polymerase kappa, putative 0.0087 0.0695 0.142
Echinococcus granulosus lamin 0.0028 0.0079 0.0048
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0054 0.0355 0.0371
Loa Loa (eye worm) hypothetical protein 0.0166 0.1528 0.1508
Schistosoma mansoni hypothetical protein 0.0024 0.0038 0.0045
Brugia malayi jmjC domain containing protein 0.0075 0.0571 0.1125
Echinococcus multilocularis dna polymerase kappa 0.0147 0.133 0.1517
Schistosoma mansoni 6-phosphofructokinase 0.0108 0.0916 0.1071
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0037 0.0168 0.0508
Loa Loa (eye worm) RNA binding protein 0.0073 0.0554 0.0531
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0073 0.0554 0.0531
Echinococcus multilocularis peregrin 0.0031 0.0103 0.0076
Brugia malayi ImpB/MucB/SamB family protein 0.0098 0.081 0.1615
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0171 0.0304
Trypanosoma brucei glucosidase, putative 0.0038 0.018 0.0368
Echinococcus multilocularis geminin 0.0178 0.1651 0.1894
Schistosoma mansoni thyroid hormone receptor 0.0135 0.1201 0.1405
Echinococcus multilocularis caspase 2 0.0184 0.1723 0.1979
Loa Loa (eye worm) TAR-binding protein 0.0073 0.0554 0.0531
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0026 0.006 0.0123
Echinococcus granulosus lysine specific demethylase 6a 0.0075 0.0571 0.0626
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0596 0.6058 1
Loa Loa (eye worm) glutaminase 0.0304 0.2978 0.2961
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0124 0.1085 0.123
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0108 0.0916 0.1871
Onchocerca volvulus 0.0196 0.1848 0.364
Brugia malayi PHD-finger family protein 0.0031 0.0103 0.0166
Loa Loa (eye worm) hypothetical protein 0.0439 0.4406 0.4393
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.0171 0.0348
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0202 0.0413
Loa Loa (eye worm) glutathione reductase 0.0047 0.0281 0.0257
Echinococcus multilocularis Glycoside hydrolase, family 27 0.021 0.1993 0.2295
Loa Loa (eye worm) pyruvate kinase 0.0033 0.013 0.0106
Schistosoma mansoni ran 0.0025 0.004 0.0047
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0096 0.0787 0.124
Leishmania major pyruvate kinase 0.0033 0.013 0.0265
Loa Loa (eye worm) hypothetical protein 0.0098 0.081 0.0787
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.4981 0.5804
Schistosoma mansoni alpha-glucosidase 0.0147 0.1329 0.1553
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0077 0.0592 0.065
Schistosoma mansoni cpg binding protein 0.0037 0.0167 0.0195
Echinococcus granulosus geminin 0.0178 0.1651 0.1894
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0052 0.0324 0.0824
Schistosoma mansoni tyrosine kinase 0.0079 0.0609 0.0712
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0026 0.006 0.0123
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0075 0.0574 0.063
Echinococcus granulosus SAM and MBT domain containing protein 0.0048 0.0285 0.029
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0047 0.0279 0.0283
Trichomonas vaginalis conserved hypothetical protein 0.0096 0.0787 0.124
Trypanosoma cruzi metacaspase 5, putative 0.0096 0.0787 0.1606
Brugia malayi RNA, U transporter 1 0.0095 0.0782 0.1558
Treponema pallidum quinoline 2-oxidoreductase 0.0029 0.0085 0.0079
Plasmodium falciparum importin beta, putative 0.0033 0.0133 0.0339
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0202 0.0269
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.0281 0.18
Schistosoma mansoni carbonic anhydrase 0.0394 0.3932 0.4597
Mycobacterium tuberculosis Probable carbon monoxyde dehydrogenase (medium chain) 0.0061 0.0427 0.1425
Plasmodium falciparum ataxin-2 like protein, putative 0.0054 0.0354 0.0901
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0213 0.0435
Plasmodium vivax hypothetical protein, conserved 0.004 0.0202 0.1299
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0075 0.0574 0.063
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0486 0.4897 1
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0128 0.0216
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.018 0.0232
Schistosoma mansoni ap endonuclease 0.0037 0.0171 0.0199
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0026 0.006 0.0036
Leishmania major DNA polymerase eta, putative 0.0052 0.0324 0.0661
Echinococcus granulosus leukotriene A 4 hydrolase 0.0026 0.006 0.0026
Brugia malayi Inositol-1 0.0041 0.0213 0.0392
Leishmania major hypothetical protein, conserved 0.0075 0.0571 0.1166
Trichomonas vaginalis conserved hypothetical protein 0.0096 0.0787 0.124
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0026 0.006 0.0386
Entamoeba histolytica aminopeptidase, putative 0.0075 0.0574 0.0912
Trypanosoma brucei phosphoglycerate kinase 0.0169 0.1558 0.3182
Mycobacterium ulcerans lipase LipD 0.004 0.0202 0.0679
Leishmania major pyruvate kinase 0.0033 0.013 0.0265
Trypanosoma brucei metacaspase MCA3 0.0096 0.0787 0.1606
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0096 0.0787 0.1568
Echinococcus multilocularis musashi 0.0028 0.0079 0.0048
Brugia malayi glutathione reductase 0.0047 0.0281 0.053
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.021 0.1993 0.233
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0025 0.0082
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0088 0.0564
Mycobacterium ulcerans esterase/lipase LipP 0.004 0.0202 0.0679
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0088 0.0079
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.018 0.0232
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0025 0.0005
Loa Loa (eye worm) hypothetical protein 0.0028 0.0073 0.0049
Schistosoma mansoni hypothetical protein 0.0033 0.0128 0.0149
Echinococcus granulosus polycomb protein SCMH1 0.0048 0.0285 0.029
Leishmania major ubiquitin-conjugating enzyme e2, putative 0.0037 0.0175 0.0357
Echinococcus multilocularis GPCR, family 2 0.0033 0.0128 0.0105
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.012 0.1047 0.3623
Trypanosoma brucei aminopeptidase, putative 0.0026 0.006 0.0123
Brugia malayi hypothetical protein 0.004 0.0205 0.0374
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0438 0.4396 0.4383
Brugia malayi 6-phosphofructokinase 0.0108 0.0916 0.1834
Schistosoma mansoni hypothetical protein 0.0033 0.0128 0.0149
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0104 0.0874 0.0982
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0075 0.0574 0.1173
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0067 0.0486 0.0526
Echinococcus multilocularis RUN 0.004 0.0205 0.0195
Loa Loa (eye worm) 6-phosphofructokinase 0.0108 0.0916 0.0894
Brugia malayi Ubiquitin conjugating enzyme protein 13 0.0037 0.0175 0.0313
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0108 0.092 0.3172
Brugia malayi polk-prov protein 0.0101 0.0844 0.1685
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0075 0.0571 0.1166
Trypanosoma brucei DNA polymerase kappa, putative 0.0147 0.133 0.2715
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0128 0.0105
Echinococcus multilocularis lipoxygenase domain containing protein 0.004 0.0205 0.0195
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.0171 0.0518
Echinococcus granulosus JmjC domain containing protein 4 0.0075 0.0571 0.0626
Loa Loa (eye worm) hypothetical protein 0.0089 0.0718 0.0695
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0124 0.1085 0.3758
Mycobacterium ulcerans hypothetical protein 0.0023 0.0025 0.0082
Trypanosoma brucei cytochrome P450, putative 0.0036 0.0158 0.0323
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0048 0.0285 0.0333
Loa Loa (eye worm) phosphofructokinase 0.0108 0.0916 0.0894
Schistosoma mansoni family M1 non-peptidase homologue (M01 family) 0.0049 0.0296 0.0346
Trypanosoma brucei DNA polymerase IV, putative 0.0147 0.133 0.2715
Trichomonas vaginalis conserved hypothetical protein 0.0096 0.0787 0.124
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0025 0.0082
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.0916 0.1456
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0025 0.0082
Trypanosoma cruzi metacaspase, putative 0.0096 0.0787 0.1606
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0104 0.0874 0.1022
Toxoplasma gondii hypothetical protein 0.0059 0.0401 0.1019
Plasmodium falciparum carbonic anhydrase 0.0394 0.3932 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0068 0.0497 0.1265
Loa Loa (eye worm) hypothetical protein 0.0026 0.006 0.0036
Toxoplasma gondii pyruvate kinase PyK1 0.0033 0.013 0.033
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.013 0.021
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0075 0.0571 0.0667
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0196 0.1844 0.2121
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0047 0.0279 0.0283
Loa Loa (eye worm) hypothetical protein 0.0394 0.3932 0.3917
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0256 0.2471 0.8668
Echinococcus multilocularis cpg binding protein 0.0037 0.0167 0.0151
Brugia malayi hypothetical protein 0.0439 0.4406 0.8993
Echinococcus multilocularis lysine specific demethylase 5A 0.0281 0.2742 0.3176
Schistosoma mansoni rab6-interacting 0.004 0.0205 0.0239
Leishmania major mitochondrial DNA polymerase beta 0.0365 0.362 0.7393
Loa Loa (eye worm) hypothetical protein 0.004 0.0202 0.0179
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0029 0.0088 0.0084
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0108 0.0916 0.1871
Echinococcus multilocularis survival motor neuron protein 1 0.0482 0.4859 0.5662
Echinococcus granulosus caspase 3 0.0157 0.1434 0.1639
Loa Loa (eye worm) pyruvate kinase 0.0033 0.013 0.0106
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.018 0.0368
Schistosoma mansoni flap endonuclease-1 0.0023 0.0027 0.0032
Brugia malayi Melibiase family protein 0.014 0.1256 0.2531
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.014 0.1256 0.1468
Mycobacterium tuberculosis Probable lipase LipE 0.004 0.0202 0.063
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.0916 0.1479
Plasmodium falciparum thioredoxin reductase 0.0047 0.0281 0.0713
Onchocerca volvulus 0.0026 0.0059 0.007
Brugia malayi jmjC domain containing protein 0.0283 0.2763 0.5622
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0169 0.1558 1
Brugia malayi ImpB/MucB/SamB family protein 0.0067 0.0486 0.0951
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0596 0.6058 1
Leishmania major carbonic anhydrase-like protein 0.0486 0.4897 1
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0253 0.244 0.282
Echinococcus multilocularis lysine specific demethylase 6a 0.0075 0.0571 0.0626
Loa Loa (eye worm) runx1 0.0055 0.0361 0.0338
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0026 0.006 0.0123
Loa Loa (eye worm) hypothetical protein 0.0031 0.0103 0.0079
Loa Loa (eye worm) inositol-1 0.0041 0.0213 0.0189
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0108 0.0916 0.3159
Brugia malayi hypothetical protein 0.0089 0.0718 0.1426
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0038 0.018 0.0156
Mycobacterium ulcerans aminopeptidase N PepN 0.0075 0.0574 0.1929
Mycobacterium ulcerans DNA polymerase IV 0.0147 0.133 0.4465
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0202 0.0269
Schistosoma mansoni caspase-7 (C14 family) 0.0184 0.1723 0.2014
Loa Loa (eye worm) pip kinase 2 0.0196 0.1848 0.1828
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.018 0.0232
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0125 0.1096 0.1242
Mycobacterium tuberculosis Probable conserved lipoprotein 0.004 0.0202 0.063
Brugia malayi mbt repeat family protein 0.0048 0.0285 0.0539
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0169 0.1558 0.3964
Entamoeba histolytica hypothetical protein 0.0027 0.0067 0.007
Brugia malayi Peptidase family M1 containing protein 0.0075 0.0574 0.1133
Echinococcus multilocularis lipoxygenase domain containing protein 0.004 0.0205 0.0195
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.018 0.0368
Schistosoma mansoni lamin 0.0028 0.0079 0.0092
Echinococcus multilocularis flap endonuclease 1 0.0026 0.0053 0.0018
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.014 0.1256 0.202
Plasmodium vivax flap endonuclease 1, putative 0.0026 0.0053 0.0342
Schistosoma mansoni inositol monophosphatase 0.0041 0.0213 0.0249
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.8554 1
Echinococcus multilocularis Protein lozenge 0.0055 0.0361 0.038
Trypanosoma cruzi metacaspase 5, putative 0.0096 0.0787 0.1606
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.8554 1
Trichomonas vaginalis inositol monophosphatase, putative 0.0041 0.0213 0.0287
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0104 0.0874 0.0982
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0096 0.0787 0.124
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0088 0.0224
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0171 0.0155
Schistosoma mansoni hypothetical protein 0.0178 0.1651 0.193
Echinococcus multilocularis 6 phosphofructokinase 0.0108 0.0916 0.1031
Brugia malayi beta-lactamase family protein 0.004 0.0202 0.0369
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0064 0.045 0.0484
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0075 0.0574 0.0888
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0124 0.1085 0.123
Echinococcus granulosus lamin dm0 0.0028 0.0079 0.0048
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.1598 0.3264
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0213 0.0435
Echinococcus granulosus neutral alpha glucosidase AB 0.0038 0.018 0.0167
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0128 0.0105
Mycobacterium leprae conserved hypothetical protein 0.004 0.0202 0.063
Mycobacterium tuberculosis Conserved hypothetical protein 0.0192 0.1804 0.6302
Mycobacterium ulcerans carbon monoxyde dehydrogenase medium chain CoxM 0.0061 0.0427 0.1433
Schistosoma mansoni lipoxygenase 0.0175 0.1622 0.1896
Loa Loa (eye worm) TK/INSR protein kinase 0.0047 0.0279 0.0255
Echinococcus multilocularis neuropeptide receptor A26 0.0517 0.5228 0.6095
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0202 0.0237
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0202 0.0269
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.013 0.021
Trypanosoma brucei pyruvate kinase 1 0.0033 0.013 0.0265
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0026 0.0053 0.0109
Echinococcus granulosus flap endonuclease 1 0.0026 0.0053 0.0018
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.014 0.1256 0.1468
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0486 0.4897 0.4885
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0026 0.006 0.0026
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0103 0.0262
Brugia malayi Pre-SET motif family protein 0.0064 0.045 0.0878
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0096 0.0787 0.124
Trypanosoma brucei phosphoglycerate kinase 0.0169 0.1558 0.3182
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0109 0.093 0.0908
Brugia malayi Cytochrome P450 family protein 0.0036 0.0158 0.0279
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0026 0.006 0.0123
Entamoeba histolytica phosphoglycerate kinase, putative 0.0169 0.1558 0.2543
Echinococcus multilocularis PHD finger protein rhinoceros 0.0031 0.0103 0.0076
Onchocerca volvulus 0.0499 0.5033 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0296 0.0272
Brugia malayi Flap endonuclease-1 0.0026 0.0053 0.0064
Entamoeba histolytica Flap nuclease, putative 0.0026 0.0053 0.0048
Echinococcus granulosus tar DNA binding protein 0.0073 0.0554 0.0606
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.0916 0.1479
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0129 0.1137 0.1329
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0088 0.0224
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0026 0.006 0.0153
Leishmania major phosphoglycerate kinase B, cytosolic 0.0169 0.1558 0.3182
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.021 0.1993 0.2295
Mycobacterium tuberculosis Probable carbon monoxyde dehydrogenase (large chain) 0.0086 0.0683 0.2331
Echinococcus granulosus PHD finger protein rhinoceros 0.0031 0.0103 0.0076
Echinococcus granulosus caspase 0.0253 0.244 0.282
Leishmania major importin beta-1 subunit, putative 0.0027 0.0067 0.0136
Brugia malayi 6-phosphofructokinase 0.0108 0.0916 0.1834
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0025 0.0082
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0087 0.0695 0.2376
Echinococcus granulosus phd:f box containing protein 0.0075 0.0571 0.0626
Trypanosoma brucei DNA polymerase kappa, putative 0.0147 0.133 0.2715
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0104 0.0874 0.1022
Brugia malayi hypothetical protein 0.0054 0.0354 0.0681
Trypanosoma brucei DNA polymerase kappa, putative 0.0066 0.0477 0.0973
Brugia malayi bHLH-PAS transcription factor 0.0038 0.0179 0.0321
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0202 0.0237
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0025 0.004 0.0082
Toxoplasma gondii melibiase subfamily protein 0.021 0.1993 0.5068
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.0916 0.1456
Mycobacterium tuberculosis Probable oxidoreductase 0.012 0.1047 0.3623
Loa Loa (eye worm) hypothetical protein 0.0048 0.0285 0.0261
Brugia malayi Glycosyl hydrolases family 31 protein 0.0171 0.1579 0.3193
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.045 0.0526
Loa Loa (eye worm) carbonic anhydrase 3 0.0486 0.4897 0.4885
Entamoeba histolytica ubiquitin-conjugating enzyme family protein 0.0037 0.0175 0.0249
Trypanosoma cruzi PAB1-binding protein , putative 0.0054 0.0354 0.0723
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.0916 0.1456
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0096 0.0787 0.124
Trichomonas vaginalis flap endonuclease-1, putative 0.0026 0.0053 0.0022
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0129 0.1137 0.3817
Schistosoma mansoni tyrosine kinase 0.0047 0.0279 0.0326
Loa Loa (eye worm) hypothetical protein 0.0033 0.0133 0.0109
Schistosoma mansoni cpg binding protein 0.0035 0.0146 0.0171
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0067 0.0044
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0067 0.0486 0.0568
Onchocerca volvulus 0.0028 0.0079 0.0108
Echinococcus granulosus lipoxygenase domain containing protein 0.004 0.0205 0.0195
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0104 0.0874 0.1022
Brugia malayi Pip kinase protein 2 0.0196 0.1848 0.3744
Toxoplasma gondii HEAT repeat-containing protein 0.0033 0.0133 0.0339
Plasmodium vivax hypothetical protein, conserved 0.0096 0.0787 0.5048
Plasmodium vivax multidomain scavenger receptor, putative 0.004 0.0205 0.1314
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0175 0.1622 0.186
Schistosoma mansoni carbonic anhydrase-related 0.0394 0.3932 0.4597
Schistosoma mansoni tyrosine kinase 0.0079 0.0618 0.0723
Echinococcus granulosus GPCR family 2 0.0033 0.0128 0.0105
Mycobacterium tuberculosis Probable lipase LipD 0.004 0.0202 0.063
Onchocerca volvulus Cell death protein 3 homolog 0.0184 0.1723 0.3391
Schistosoma mansoni importin beta-1 0.0033 0.0133 0.0156
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0596 0.6058 1
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0129 0.1137 0.129
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0026 0.006 0.0123
Onchocerca volvulus 0.004 0.0202 0.0355
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0037 0.0175 0.0223
Echinococcus multilocularis jumonji domain containing protein 0.0043 0.0229 0.0224
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0596 0.6058 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0321 0.0656
Loa Loa (eye worm) jmjC domain-containing protein 0.0075 0.0571 0.0548
Loa Loa (eye worm) cytochrome P450 family protein 0.0036 0.0158 0.0134
Echinococcus granulosus inositol monophosphatase 1 0.0041 0.0213 0.0206
Loa Loa (eye worm) peptidase family M1 containing protein 0.0026 0.006 0.0036
Schistosoma mansoni phosphoglycerate kinase 0.0169 0.1558 0.1822
Echinococcus multilocularis caspase 8 0.0096 0.0787 0.0879
Trypanosoma brucei DNA polymerase kappa, putative 0.0101 0.0844 0.1723
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0025 0.005
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0096 0.0787 0.124
Mycobacterium ulcerans beta-lactamase 0.004 0.0202 0.0679
Trypanosoma brucei unspecified product 0.0127 0.112 0.2288
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0169 0.1558 0.3964
Echinococcus multilocularis thyroid hormone receptor alpha 0.0135 0.1201 0.1366
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.0171 0.0282
Trypanosoma brucei metacaspase MCA2 0.0096 0.0787 0.1606
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0169 0.1558 0.3182
Loa Loa (eye worm) hypoxia-induced factor 1 0.0158 0.1442 0.1422
Trypanosoma brucei DNA polymerase IV, putative 0.0127 0.112 0.2288
Loa Loa (eye worm) hypothetical protein 0.0118 0.1019 0.0997
Giardia lamblia DINP protein human, muc B family 0.0087 0.0695 0.1148
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0062 0.0434 0.0886
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0394 0.3932 0.802
Echinococcus granulosus pyruvate kinase 0.0033 0.013 0.0107
Mycobacterium ulcerans hypothetical protein 0.004 0.0202 0.0679
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0075 0.0574 0.1173
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0171 0.0434
Toxoplasma gondii aldehyde dehydrogenase 0.0124 0.1085 0.276
Leishmania major GTP-binding protein, putative 0.0025 0.004 0.0082
Echinococcus granulosus intermediate filament protein 0.0028 0.0079 0.0048
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.018 0.0232
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0075 0.0574 0.0888
Schistosoma mansoni cpg binding protein 0.0037 0.0167 0.0195
Mycobacterium ulcerans carbon monoxyde dehydrogenase large chain CoxL 0.0086 0.0683 0.2292
Toxoplasma gondii hypothetical protein 0.0394 0.3932 1
Toxoplasma gondii ABC1 family protein 0.004 0.0202 0.0515
Echinococcus multilocularis lysosomal alpha glucosidase 0.0171 0.1579 0.1809
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0486 0.4897 0.5726
Treponema pallidum exodeoxyribonuclease (exoA) 0.0037 0.0171 0.0222
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0075 0.0573 0.117
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0285 0.0333
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.0202 0.0179
Leishmania major trypanothione reductase 0.0047 0.0281 0.0573
Trypanosoma brucei metacaspase 0.0096 0.0787 0.1606
Trypanosoma brucei Aminopeptidase M1, putative 0.0075 0.0574 0.1173
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0041 0.0213 0.0542
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0104 0.0874 0.0852
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0096 0.0787 0.2001
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0596 0.6058 1
Echinococcus multilocularis jumonji domain containing 1A 0.0075 0.0571 0.0626
Echinococcus multilocularis snurportin 1 0.0357 0.3538 0.411
Schistosoma mansoni rab6-interacting 0.004 0.0205 0.0239
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0098 0.0817 0.163
Brugia malayi Doublecortin family protein 0.004 0.0205 0.0374
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0554 0.0648
Trypanosoma brucei DNA polymerase kappa, putative 0.0147 0.133 0.2715
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0171 0.0155
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0026 0.0053 0.0109
Echinococcus granulosus carbonic anhydrase II 0.0486 0.4897 0.5706
Echinococcus granulosus phosphatidylinositol 5 phosphate 4 kinase type 2 0.0196 0.1848 0.2125
Toxoplasma gondii aminopeptidase N, putative 0.0026 0.006 0.0153
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0486 0.4897 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0076 0.058 0.0678
Brugia malayi hypothetical protein 0.0026 0.006 0.0078
Plasmodium vivax JmjC domain containing protein 0.0075 0.0571 0.3663
Brugia malayi intermediate filament protein 0.0028 0.0079 0.0116
Schistosoma mansoni hypothetical protein 0.0125 0.1096 0.1281
Onchocerca volvulus 0.004 0.0202 0.0355
Toxoplasma gondii aminopeptidase N protein 0.0026 0.006 0.0153
Trypanosoma cruzi DNA polymerase kappa, putative 0.0147 0.133 0.2715
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0088 0.0079
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0103 0.0661
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0128 0.0216
Loa Loa (eye worm) hypothetical protein 0.0184 0.1723 0.1703
Echinococcus multilocularis phosphoglycerate kinase 1 0.0169 0.1558 0.1785
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0133 0.0272
Schistosoma mansoni aminopeptidase A (M01 family) 0.0026 0.006 0.007
Schistosoma mansoni hypothetical protein 0.0033 0.0128 0.0149
Echinococcus multilocularis JmjC domain containing protein 4 0.0075 0.0571 0.0626
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0079 0.0055
Brugia malayi Glycosyl hydrolases family 31 protein 0.0038 0.018 0.0324
Loa Loa (eye worm) hypothetical protein 0.004 0.0202 0.0179
Trichomonas vaginalis maltase-glucoamylase, putative 0.0038 0.018 0.0232
Echinococcus granulosus cpg binding protein 0.0037 0.0167 0.0151
Schistosoma mansoni hypothetical protein 0.0031 0.0103 0.012
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0196 0.1848 0.216
Loa Loa (eye worm) hypothetical protein 0.014 0.1256 0.1235
Loa Loa (eye worm) doublecortin family protein 0.004 0.0205 0.0181
Echinococcus multilocularis epidermal growth factor receptor 0.0148 0.1339 0.1527
Echinococcus multilocularis carbonic anhydrase 0.0394 0.3932 0.4573
Mycobacterium ulcerans aldehyde dehydrogenase 0.0124 0.1085 0.3644
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0096 0.0787 0.124
Mycobacterium ulcerans aerobic-type carbon monoxide dehydrogenase subunit CoxL_2 0.0086 0.0683 0.2292
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0062 0.0439 0.0897
Onchocerca volvulus 0.0089 0.0718 0.1384
Mycobacterium tuberculosis Conserved hypothetical protein 0.0067 0.0486 0.1635
Schistosoma mansoni hypothetical protein 0.004 0.0205 0.0239
Mycobacterium ulcerans aminopeptidase N PepN 0.0026 0.006 0.0202
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0554 0.0648
Echinococcus granulosus aminopeptidase N 0.0075 0.0574 0.063
Schistosoma mansoni hypothetical protein 0.0298 0.2921 0.3415
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.018 0.0232
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0486 0.4897 0.5726
Echinococcus multilocularis pyruvate kinase 0.0033 0.013 0.0107
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.0088 0.0106
Echinococcus multilocularis ubiquitin conjugating enzyme E2 N 0.0037 0.0175 0.016
Echinococcus multilocularis expressed protein 0.037 0.3679 0.4275
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0104 0.0876 0.1751
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0026 0.006 0.007
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0088 0.0079
Schistosoma mansoni hypothetical protein 0.0394 0.3932 0.4597
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.013 0.0148
Trypanosoma brucei Aminopeptidase M1, putative 0.0075 0.0574 0.1173
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.004 0.0202 0.0679
Trypanosoma cruzi Aminopeptidase M1, putative 0.0075 0.0574 0.1173
Mycobacterium ulcerans pyruvate kinase 0.0033 0.013 0.0435
Loa Loa (eye worm) hypothetical protein 0.0028 0.0079 0.0055
Schistosoma mansoni pyruvate kinase 0.0033 0.013 0.0152
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0596 0.6058 1
Trypanosoma brucei DNA polymerase IV, putative 0.0147 0.133 0.2715
Loa Loa (eye worm) hypothetical protein 0.0196 0.1848 0.1828
Echinococcus granulosus GTP binding nuclear protein Ran 0.0025 0.004 0.0002
Echinococcus granulosus dnaJ subfamily B 0.0494 0.4981 0.5804
Schistosoma mansoni alpha-glucosidase 0.0147 0.1329 0.1553
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0202 0.0269
Brugia malayi hypothetical protein 0.0075 0.0574 0.1133
Schistosoma mansoni phd/f-box containing protein 0.0075 0.0571 0.0667
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.012 0.1047 0.3623
Trichomonas vaginalis xanthine dehydrogenase, putative 0.0182 0.1693 0.2747
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0103 0.0262
Trypanosoma brucei DNA polymerase eta, putative 0.0098 0.081 0.1653
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.018 0.0232
Echinococcus multilocularis transfer RNA-Lys 0.0038 0.0179 0.0165
Giardia lamblia PHD finger protein 15 0.0031 0.0103 0.017
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0321 0.0656
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0281 0.0284
Treponema pallidum fructose-bisphosphate aldolase 0.0596 0.6058 1
Loa Loa (eye worm) hypothetical protein 0.0482 0.4859 0.4847
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.004 0.0202 0.063
Loa Loa (eye worm) 6-phosphofructokinase 0.0108 0.0916 0.0894
Echinococcus multilocularis muscleblind protein 1 0.0166 0.1528 0.175
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.021 0.1993 0.233
Echinococcus granulosus neuropeptide receptor A26 0.0517 0.5228 0.6095
Echinococcus granulosus dna polymerase eta 0.0098 0.081 0.0906
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0075 0.0574 0.1173
Echinococcus granulosus muscleblind protein 0.0166 0.1528 0.175
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0394 0.3932 0.802
Brugia malayi RNA recognition motif domain containing protein 0.0073 0.0554 0.1091
Echinococcus granulosus RUN 0.004 0.0205 0.0195
Trichomonas vaginalis glutaminase, putative 0.0304 0.2978 0.4882
Schistosoma mansoni hypothetical protein 0.0098 0.0817 0.0955
Plasmodium falciparum phd finger protein, putative 0.0031 0.0103 0.0262
Loa Loa (eye worm) jmjC domain-containing protein 0.0063 0.0445 0.0422
Leishmania major DNA polymerase eta, putative 0.0098 0.081 0.1653
Onchocerca volvulus 0.004 0.0205 0.036
Onchocerca volvulus 0.0026 0.006 0.0071
Loa Loa (eye worm) beta-lactamase 0.004 0.0202 0.0179
Echinococcus granulosus pyruvate kinase 0.0033 0.013 0.0107
Onchocerca volvulus 0.0075 0.0574 0.1098
Loa Loa (eye worm) glutaminase 2 0.0304 0.2978 0.2961
Brugia malayi Peptidase family M1 containing protein 0.0026 0.006 0.0078
Brugia malayi Pyruvate kinase, muscle isozyme 0.0033 0.013 0.022
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.012 0.1047 0.3623
Echinococcus multilocularis pyruvate kinase 0.0033 0.013 0.0107
Schistosoma mansoni phosphoglycerate kinase 0.0169 0.1558 0.1822
Echinococcus granulosus jumonji domain containing 1A 0.0075 0.0571 0.0626
Schistosoma mansoni myelin transcription factor 1 myt1 0.0054 0.0355 0.0415
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0169 0.1558 0.2523
Mycobacterium tuberculosis Probable reductase 0.0108 0.092 0.3172
Echinococcus multilocularis SAM and MBT domain containing protein 0.0048 0.0285 0.029
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0486 0.4897 1
Schistosoma mansoni DNA polymerase eta 0.0098 0.081 0.0947
Brugia malayi Cytochrome P450 family protein 0.0036 0.0158 0.0279
Brugia malayi latrophilin 2 splice variant baaae 0.0071 0.0529 0.104
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0108 0.092 0.3172
Toxoplasma gondii ubiquitin-conjugating enzyme subfamily protein 0.0037 0.0175 0.0444
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0196 0.1844 0.2121
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0128 0.0105
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0025 0.0005
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0202 0.0413
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0037 0.0175 0.0357
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0025 0.0005
Trypanosoma brucei DNA polymerase kappa, putative 0.0066 0.0477 0.0973
Brugia malayi hypoxia-induced factor 1 0.0158 0.1442 0.2913
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0075 0.0574 0.063
Schistosoma mansoni phosphatidylserine receptor 0.0075 0.0571 0.0667
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0064 0.045 0.1145
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0048 0.0285 0.052
Schistosoma mansoni tyrosine kinase 0.0079 0.0609 0.0712
Brugia malayi ubiquitin conjugating enzyme protein 13 0.0037 0.0175 0.0313
Plasmodium vivax phosphoglycerate kinase, putative 0.0169 0.1558 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0596 0.6058 1
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0096 0.0787 0.2001
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0037 0.0175 0.0357
Schistosoma mansoni hypothetical protein 0.0033 0.0128 0.0149
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.0171 0.0348
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.021 0.1993 0.233
Brugia malayi jmjC domain containing protein 0.0344 0.3407 0.6942
Schistosoma mansoni ran 0.0025 0.004 0.0047
Loa Loa (eye worm) hypothetical protein 0.0075 0.0571 0.0548
Leishmania major DNA polymerase kappa, putative 0.0087 0.0695 0.142
Schistosoma mansoni hypothetical protein 0.0494 0.4981 0.5823
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0037 0.0175 0.0151
Plasmodium falciparum glutathione reductase 0.0047 0.0281 0.0713
Schistosoma mansoni carbonic anhydrase-related 0.0394 0.3932 0.4597
Schistosoma mansoni hypothetical protein 0.0089 0.0718 0.0839
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0075 0.0574 0.0671
Brugia malayi jmjC domain containing protein 0.0075 0.0571 0.1125
Brugia malayi Calcitonin receptor-like protein seb-1 0.0104 0.0876 0.1751
Leishmania major hypothetical protein, conserved 0.004 0.0202 0.0413
Echinococcus granulosus lysosomal alpha glucosidase 0.0171 0.1579 0.1809
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0096 0.0787 0.092
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0108 0.092 0.3172
Toxoplasma gondii Alpha-galactosidase 0.003 0.0094 0.024
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0075 0.0571 0.1452
Brugia malayi TATA binding protein associated factor 0.0026 0.006 0.0078
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0128 0.0104
Echinococcus multilocularis epidermal growth factor receptor 0.0079 0.0618 0.0681
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0041 0.0213 0.0287
Mycobacterium leprae Probable lipase LipE 0.004 0.0202 0.063
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.0171 0.0573
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0026 0.0053 0.0109
Echinococcus multilocularis lysosomal alpha glucosidase 0.0171 0.1579 0.1809
Brugia malayi glutaminase DH11.1 0.0304 0.2978 0.6064
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0088 0.0224
Plasmodium falciparum ubiquitin-conjugating enzyme E2 N, putative 0.0037 0.0175 0.0444
Echinococcus multilocularis polycomb protein SCMH1 0.0048 0.0285 0.029
Schistosoma mansoni jumonji domain containing protein 0.0075 0.0571 0.0667
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0026 0.006 0.0026
Trypanosoma brucei DNA polymerase kappa, putative 0.0147 0.133 0.2715
Schistosoma mansoni survival motor neuron protein 0.0098 0.0817 0.0955
Echinococcus granulosus histone acetyltransferase MYST2 0.0054 0.0355 0.0371
Mycobacterium ulcerans carbon monoxide dehydrogenase 0.012 0.1048 0.3518
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0054 0.0355 0.0682
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0037 0.0175 0.0223
Schistosoma mansoni tyrosine kinase 0.0079 0.0618 0.0723
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0088 0.0224
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0025 0.005
Mycobacterium tuberculosis Conserved protein 0.004 0.0202 0.063
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0804 0.8249 0.9642
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0037 0.0175 0.0151
Trichomonas vaginalis conserved hypothetical protein 0.0096 0.0787 0.124
Loa Loa (eye worm) cytochrome P450 family protein 0.0036 0.0158 0.0134
Echinococcus multilocularis histone acetyltransferase MYST2 0.0054 0.0355 0.0371
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0096 0.0787 0.2001
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0025 0.004 0.0037
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0202 0.0413
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0075 0.0573 0.117
Treponema pallidum methylgalactoside ABC transporter, periplasmic galactose-binding protein (mglB-1) 0.0265 0.2567 0.4202
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 0.362 0.7393
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0202 0.0269
Trypanosoma cruzi aminopeptidase, putative 0.0075 0.0574 0.1173
Loa Loa (eye worm) aminopeptidase N 0.0075 0.0574 0.0551
Echinococcus granulosus dna polymerase kappa 0.0147 0.133 0.1517
Schistosoma mansoni lipoxygenase 0.0102 0.086 0.1005
Echinococcus granulosus epidermal growth factor receptor 0.0079 0.0618 0.0681
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0128 0.0105
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0253 0.244 0.282
Plasmodium falciparum metacaspase 1 0.0096 0.0787 0.2001
Trichomonas vaginalis xanthine dehydrogenase, putative 0.0182 0.1693 0.2747
Loa Loa (eye worm) hypothetical protein 0.0439 0.4406 0.4393
Echinococcus granulosus lipoxygenase domain containing protein 0.004 0.0205 0.0195
Loa Loa (eye worm) hypothetical protein 0.0104 0.0876 0.0854
Loa Loa (eye worm) PHD-finger family protein 0.0031 0.0103 0.0079
Loa Loa (eye worm) hypothetical protein 0.0049 0.0296 0.0272
Mycobacterium tuberculosis Probable dehydrogenase 0.0108 0.092 0.3172
Schistosoma mansoni hypothetical protein 0.0071 0.0529 0.0619
Trypanosoma brucei DNA polymerase kappa, putative 0.0147 0.133 0.2715
Loa Loa (eye worm) MBCTL1 0.0054 0.0355 0.0331
Trypanosoma cruzi aminopeptidase, putative 0.0026 0.006 0.0123
Echinococcus granulosus epidermal growth factor receptor 0.0148 0.1339 0.1527
Loa Loa (eye worm) hypothetical protein 0.004 0.0202 0.0179
Toxoplasma gondii aminopeptidase n, putative 0.0026 0.006 0.0153
Loa Loa (eye worm) flap endonuclease-1 0.0026 0.0053 0.0029
Trypanosoma brucei phosphoglycerate kinase, putative 0.0062 0.0434 0.0886
Echinococcus granulosus peregrin 0.0031 0.0103 0.0076
Brugia malayi TAR-binding protein 0.0073 0.0554 0.1091
Echinococcus multilocularis carbonic anhydrase II 0.0486 0.4897 0.5706
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0088 0.0564
Loa Loa (eye worm) hypothetical protein 0.0169 0.1558 0.1538
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0025 0.0082
Trypanosoma brucei DNA polymerase kappa, putative 0.0101 0.0844 0.1723
Leishmania major hypothetical protein, conserved 0.0054 0.0354 0.0723
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0025 0.004 0.0102
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.0202 0.0369
Mycobacterium ulcerans aldehyde dehydrogenase 0.0124 0.1085 0.3644
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0124 0.1085 0.2216
Echinococcus granulosus caspase 8 0.0096 0.0787 0.0879
Treponema pallidum methylgalactoside ABC transporter, periplasmic galactose-binding protein (mglB-2) 0.0265 0.2567 0.4202
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0129 0.1137 0.3941
Schistosoma mansoni hypothetical protein 0.0357 0.3538 0.4136
Brugia malayi Peptidase family M1 containing protein 0.0075 0.0574 0.1133
Echinococcus multilocularis phosphatidylinositol 5 phosphate 4 kinase type 2 0.0196 0.1848 0.2125
Brugia malayi Protein kinase domain containing protein 0.0047 0.0279 0.0527
Plasmodium falciparum pyruvate kinase 0.0033 0.013 0.033
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0104 0.0874 0.0982
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0025 0.005
Trichomonas vaginalis DNA polymerase eta, putative 0.0147 0.133 0.2143
Trypanosoma cruzi metacaspase, putative 0.0096 0.0787 0.1606
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0036 0.0158 0.0532
Trypanosoma brucei DNA polymerase kappa, putative 0.0147 0.133 0.2715
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.0916 0.1456
Echinococcus granulosus snurportin 1 0.0357 0.3538 0.411
Onchocerca volvulus 0.0038 0.0179 0.0308
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0025 0.004 0.0016
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.018 0.0232
Schistosoma mansoni ap endonuclease 0.0037 0.0171 0.0199
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0025 0.004 0.0082
Brugia malayi hypothetical protein 0.0482 0.4859 0.9922
Loa Loa (eye worm) hypothetical protein 0.0049 0.0296 0.0272
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0041 0.0213 0.0307
Echinococcus multilocularis carbonic anhydrase 0.0394 0.3932 0.4573
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0147 0.133 0.2143
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0025 0.0082
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0291 0.2847 0.956
Toxoplasma gondii exonuclease III APE 0.0037 0.0171 0.0434
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0554 0.0648
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0041 0.0209 0.0532
Trypanosoma cruzi metacaspase, putative 0.0096 0.0787 0.1606
Chlamydia trachomatis pyruvate kinase 0.0033 0.013 0.0284
Trypanosoma cruzi metacaspase, putative 0.0096 0.0787 0.1606
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.045 0.0526
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0025 0.0082
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0169 0.1558 0.5434
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0025 0.004 0.0066
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.018 0.0258
Mycobacterium ulcerans aerobic-type carbon monoxide dehydrogenase subunit CoxM_2 0.0061 0.0427 0.1433
Echinococcus granulosus carbonic anhydrase 0.0394 0.3932 0.4573
Plasmodium vivax glutathione reductase, putative 0.0047 0.0281 0.18
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0038 0.018 0.0458
Trichomonas vaginalis importin beta-1, putative 0.0027 0.0067 0.0044
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0025 0.004 0.0002
Trypanosoma brucei pyruvate kinase 1, putative 0.0033 0.013 0.0265
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0026 0.006 0.0386
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0394 0.3932 0.802
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0554 0.0648
Trypanosoma cruzi DNA polymerase kappa, putative 0.0147 0.133 0.2715
Brugia malayi jmjC domain containing protein 0.0075 0.0571 0.1125
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.021 0.1993 0.233
Echinococcus granulosus survival motor neuron protein 1 0.0482 0.4859 0.5662
Schistosoma mansoni ubiquitin conjugating enzyme 13 0.0037 0.0175 0.0204
Loa Loa (eye worm) hypothetical protein 0.0166 0.1528 0.1508
Trypanosoma cruzi importin beta-1 subunit, putative 0.0027 0.0067 0.0136
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0062 0.0434 0.0886
Mycobacterium ulcerans carbon monoxyde dehydrogenase large chain CoxL 0.0054 0.0348 0.1168
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0108 0.092 0.3172
Treponema pallidum hypothetical protein 0.003 0.0092 0.0091
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.013 0.0265
Loa Loa (eye worm) pyruvate kinase 0.0033 0.013 0.0106
Loa Loa (eye worm) hypothetical protein 0.0071 0.0529 0.0506
Schistosoma mansoni intermediate filament proteins 0.0028 0.0079 0.0092
Onchocerca volvulus 0.004 0.0202 0.0355
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0169 0.1558 0.3182
Plasmodium vivax pyruvate kinase, putative 0.0033 0.013 0.0832
Schistosoma mansoni lamin 0.0028 0.0079 0.0092
Schistosoma mansoni glutaminase 0.0304 0.2978 0.3482
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0213 0.0435
Echinococcus multilocularis 0.0046 0.0263 0.0264
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0357 0.3538 0.3522
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0088 0.0079
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.0202 0.0193
Brugia malayi beta-lactamase family protein 0.004 0.0202 0.0369
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0075 0.0573 0.117
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0133 0.0272
Loa Loa (eye worm) hypothetical protein 0.0033 0.0128 0.0104
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0075 0.0574 0.063
Brugia malayi Phosphoglycerate kinase 0.0062 0.0434 0.0844
Loa Loa (eye worm) hypothetical protein 0.0026 0.006 0.0036
Brugia malayi Cell death protein 3 precursor 0.0184 0.1723 0.3489
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.0171 0.0243
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0173 0.1598 0.3264
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0108 0.0916 0.3159
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0075 0.0574 0.0671
Echinococcus multilocularis insulin receptor 0.0047 0.0279 0.0283
Leishmania major ATP-dependent phosphofructokinase 0.0108 0.0916 0.1871
Giardia lamblia Pyruvate kinase 0.0033 0.013 0.0214
Trypanosoma brucei DNA polymerase kappa, putative 0.0066 0.0477 0.0973
Schistosoma mansoni tyrosine kinase 0.0079 0.0609 0.0712
Giardia lamblia Phosphoglycerate kinase 0.0169 0.1558 0.2573
Loa Loa (eye worm) jmjC domain-containing protein 0.0075 0.0571 0.0548
Plasmodium falciparum flap endonuclease 1 0.0026 0.0053 0.0135
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0554 0.0648
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.1598 0.3264
Giardia lamblia Flap structure-specific endonuclease 0.0026 0.0053 0.0088
Schistosoma mansoni tyrosine kinase 0.0148 0.1339 0.1565
Echinococcus multilocularis inositol monophosphatase 1 0.0041 0.0213 0.0206
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0344 0.3407 0.3956
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0075 0.0574 0.063
Schistosoma mansoni carbonic anhydrase-related 0.0394 0.3932 0.4597
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0321 0.0656
Toxoplasma gondii LsmAD domain-containing protein 0.0054 0.0354 0.0901
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0077 0.0592 0.065
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0026 0.006 0.0123
Echinococcus multilocularis dna polymerase eta 0.0098 0.081 0.0906
Echinococcus multilocularis pyruvate kinase 0.0026 0.0056 0.0021
Mycobacterium ulcerans DNA polymerase IV 0.0147 0.133 0.4465
Trypanosoma cruzi PAB1-binding protein , putative 0.0054 0.0354 0.0723
Loa Loa (eye worm) hypothetical protein 0.0394 0.3932 0.3917
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0171 0.0147
Schistosoma mansoni pyruvate kinase 0.0033 0.013 0.0152
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0596 0.6058 1
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0291 0.2847 1
Mycobacterium tuberculosis Conserved protein 0.004 0.0202 0.063
Schistosoma mansoni jumonji domain containing protein 0.0324 0.319 0.3729
Trypanosoma brucei DNA polymerase kappa, putative 0.0147 0.133 0.2715
Echinococcus granulosus expressed protein 0.037 0.3679 0.4275
Schistosoma mansoni thyroid hormone receptor 0.0135 0.1201 0.1405
Leishmania major metacaspase, putative 0.0096 0.0787 0.1606
Echinococcus granulosus Polycystic kidney disease protein 0.004 0.0205 0.0195
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0104 0.0874 0.1748
Onchocerca volvulus 0.0035 0.0146 0.0243
Schistosoma mansoni polycystin 1-related 0.004 0.0205 0.0239
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0125 0.1096 0.1242
Schistosoma mansoni protein phosphatase 2C 0.0075 0.0571 0.0667
Mycobacterium ulcerans putative regulatory protein 0.0038 0.0179 0.0599
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.018 0.0258
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0075 0.0574 0.1173
Echinococcus granulosus caspase 2 0.0184 0.1723 0.1979
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.006 0.0418 0.0446
Plasmodium vivax ubiquitin-conjugating enzyme E2 N, putative 0.0037 0.0175 0.1121
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0088 0.0224
Brugia malayi beta-lactamase 0.004 0.0202 0.0369
Leishmania major cytochrome p450-like protein 0.0036 0.0158 0.0323
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 0.362 0.7393
Brugia malayi Bromodomain containing protein 0.0031 0.0103 0.0166
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0026 0.006 0.0153
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0079 0.0116
Brugia malayi Pyruvate kinase, M2 isozyme 0.0033 0.013 0.022
Loa Loa (eye worm) hypothetical protein 0.0054 0.0355 0.0331
Chlamydia trachomatis phosphoglycerate kinase 0.0169 0.1558 1
Mycobacterium ulcerans hypothetical protein 0.003 0.0092 0.0309
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0596 0.6058 1
Schistosoma mansoni lozenge 0.0055 0.0361 0.0423
Trypanosoma cruzi cytochrome P450, putative 0.0036 0.0158 0.0323
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0079 0.0618 0.0681
Echinococcus granulosus carbonic anhydrase 0.0394 0.3932 0.4573
Mycobacterium ulcerans hypothetical protein 0.0192 0.1804 0.6056
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0067 0.0044
Trypanosoma brucei DNA polymerase kappa, putative 0.0147 0.133 0.2715
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0486 0.4897 1
Brugia malayi phosphofructokinase 0.0108 0.0916 0.1834
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0596 0.6058 1
Onchocerca volvulus 0.0075 0.0574 0.1098
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0054 0.0355 0.0371
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0075 0.0571 0.1166
Mycobacterium ulcerans glutaminase 0.0304 0.2978 1
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0394 0.3932 0.802
Loa Loa (eye worm) jmjC domain-containing protein 0.0283 0.2763 0.2746
Echinococcus granulosus phosphoglycerate kinase 1 0.0169 0.1558 0.1785
Mycobacterium ulcerans 6-phosphofructokinase 0.0108 0.0916 0.3077
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0394 0.3932 0.3917
Plasmodium falciparum JmjC domain-containing protein, putative 0.0075 0.0571 0.1452
Trypanosoma cruzi DNA polymerase kappa, putative 0.0147 0.133 0.2715
Loa Loa (eye worm) hypothetical protein 0.0064 0.045 0.0427
Schistosoma mansoni caspase-3 (C14 family) 0.0253 0.244 0.2852
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0129 0.1137 0.3817
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.0171 0.0348
Schistosoma mansoni aldehyde dehydrogenase 0.0124 0.1085 0.1269
Loa Loa (eye worm) hypothetical protein 0.004 0.0205 0.0181
Trypanosoma brucei PAB1-binding protein , putative 0.0054 0.0354 0.0723
Trichomonas vaginalis set domain proteins, putative 0.0499 0.5033 0.8297
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0394 0.3932 0.802
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0025 0.004 0.0102
Mycobacterium ulcerans carbon monoxyde dehydrogenase small chain CoxS 0.0035 0.0146 0.0491
Brugia malayi hypothetical protein 0.0171 0.1582 0.3199
Loa Loa (eye worm) hypothetical protein 0.004 0.0205 0.0181
Loa Loa (eye worm) hypothetical protein 0.0054 0.0354 0.0331
Leishmania major phosphoglycerate kinase C, glycosomal 0.0169 0.1558 0.3182
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0041 0.0213 0.0313
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0021 0.0001 0.0002
Echinococcus granulosus ubiquitin conjugating enzyme E2 N 0.0037 0.0175 0.016
Plasmodium falciparum ataxin-2 like protein, putative 0.0054 0.0354 0.0901
Loa Loa (eye worm) hypothetical protein 0.0101 0.0844 0.0822
Trichomonas vaginalis aldehyde oxidase, putative 0.0182 0.1693 0.2747
Mycobacterium leprae Possible D-ribose-binding protein 0.0265 0.2567 0.9008
Echinococcus granulosus 6 phosphofructokinase 0.0108 0.0916 0.1031
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0088 0.0079
Onchocerca volvulus 0.0048 0.0285 0.052
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0088 0.0079
Echinococcus granulosus carbonic anhydrase 0.0394 0.3932 0.4573
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0029 0.0088 0.0145
Giardia lamblia Fructose-bisphosphate aldolase 0.0596 0.6058 1
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0051 0.0321 0.0656
Trypanosoma brucei phosphoglycerate kinase 0.0062 0.0434 0.0886
Plasmodium vivax ataxin-2 like protein, putative 0.0054 0.0354 0.2273
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0087 0.0695 0.142
Mycobacterium ulcerans aldehyde dehydrogenase 0.0124 0.1085 0.3644
Schistosoma mansoni hypothetical protein 0.0178 0.1651 0.193
Trypanosoma brucei ubiquitin-protein ligase, putative 0.0037 0.0175 0.0357
Schistosoma mansoni hypothetical protein 0.0101 0.0848 0.0991
Brugia malayi hypothetical protein 0.004 0.0205 0.0374
Echinococcus granulosus neuropeptide s receptor 0.0517 0.5228 0.6095
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0026 0.006 0.0033
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0026 0.006 0.007
Trypanosoma cruzi DNA polymerase kappa, putative 0.0147 0.133 0.2715
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0129 0.1137 0.2287
Brugia malayi CXXC zinc finger family protein 0.0035 0.0146 0.0255
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0075 0.0574 0.063
Brugia malayi Muscleblind-like protein 0.0166 0.1528 0.3089
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0344 0.3407 0.3956
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.013 0.021
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0365 0.362 0.7393
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0171 0.1095
Brugia malayi Phosphoglycerate kinase 0.0169 0.1558 0.3151
Mycobacterium tuberculosis Probable hydrolase 0.004 0.0202 0.063
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0285 0.0333
Brugia malayi PAS domain containing protein 0.0051 0.0318 0.0607
Plasmodium falciparum LCCL domain-containing protein 0.004 0.0205 0.0521
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0281 0.0573
Trypanosoma brucei trypanothione reductase 0.0047 0.0281 0.0573
Trypanosoma brucei DNA polymerase kappa, putative 0.0147 0.133 0.2715
Schistosoma mansoni jumonji/arid domain-containing protein 0.0283 0.2763 0.323
Entamoeba histolytica Ran family GTPase 0.0025 0.004 0.0027
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0096 0.0787 0.124
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0281 0.0257
Trypanosoma brucei metacaspase 5, putative 0.0096 0.0787 0.1606
Echinococcus multilocularis carbonic anhydrase 0.0394 0.3932 0.4573
Loa Loa (eye worm) TATA binding protein associated factor 0.0026 0.006 0.0036
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0026 0.0053 0.0135
Echinococcus multilocularis tar DNA binding protein 0.0073 0.0554 0.0606
Schistosoma mansoni caspase-7 (C14 family) 0.0253 0.244 0.2852
Echinococcus multilocularis aminopeptidase N 0.0075 0.0574 0.063
Brugia malayi jmjC domain containing protein 0.0075 0.0571 0.1125

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.8913 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.5119 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) = 7.9433 um PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (binding) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 14.1254 uM PUBCHEM_BIOASSAY: Inhibitors of DNA Polymerase Beta: Hit validation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485311] ChEMBL. No reference
Potency (functional) 17.7828 uM PubChem BioAssay. qHTS for Inhibitors of PI5P4K: Confirmation in Primary Assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 20.5962 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 75.6863 uM PubChem BioAssay. qHTS for Inhibitors of Polymerase Eta: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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