Detailed information for compound 1388354

Basic information

Technical information
  • TDR Targets ID: 1388354
  • Name: 4-methoxy-N-(4-nitrophenyl)diazenylaniline
  • MW: 272.259 | Formula: C13H12N4O3
  • H donors: 1 H acceptors: 2 LogP: 3.81 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)NN=Nc1ccc(cc1)[N+](=O)[O-]
  • InChi: 1S/C13H12N4O3/c1-20-13-8-4-11(5-9-13)15-16-14-10-2-6-12(7-3-10)17(18)19/h2-9H,1H3,(H,14,15)
  • InChiKey: COVFQWCZXRVBBP-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 4-methoxy-N-(4-nitrophenyl)azo-aniline
  • 4-methoxy-N-(4-nitrophenyl)azoaniline
  • (4-methoxyphenyl)-(4-nitrophenyl)azo-amine
  • 4-methoxy-N-(4-nitrophenyl)diazenyl-aniline
  • NSC69815
  • MLS001000607
  • SMR000496128
  • ZINC03898528
  • 1-(4-methoxyphenyl)-3-(4-nitrophenyl)-1-triazene

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens multiple endocrine neoplasia I No references
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens breast cancer 1, early onset Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Homo sapiens Niemann-Pick disease, type C1 Starlite/ChEMBL No references
Homo sapiens snurportin 1 No references
Homo sapiens RAB9A, member RAS oncogene family Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni niemann-pick C1 (NPC1) Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Entamoeba histolytica Niemann-Pick C1 protein, putative Get druggable targets OG5_128206 All targets in OG5_128206
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans potential membrane protein similar to S. cerevisiae NCR1 (YPL006W) and human NPC1 late endosomal protein involved in sterol home Get druggable targets OG5_128206 All targets in OG5_128206
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K07003 Niemann Pick type C1, putative Get druggable targets OG5_128206 All targets in OG5_128206
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi Niemann-Pick C1 protein precursor Get druggable targets OG5_128206 All targets in OG5_128206
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Plasmodium falciparum ras-related protein Rab-5B RAB9A, member RAS oncogene family 201 aa 165 aa 30.9 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus cathepsin L cysteine protease 0.0076 0.0707 0.1412
Brugia malayi Patched family protein 0.0007 0.0002 0.0006
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0032 0.0261 0.1903
Onchocerca volvulus 0.0029 0.0222 0.1619
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0452 0.3319
Brugia malayi hypothetical protein 0.0007 0.0002 0.0006
Onchocerca volvulus 0.014 0.1363 1
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.014 0.1363 0.3633
Loa Loa (eye worm) hypothetical protein 0.0007 0.0002 0.0004
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.014 0.1363 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0222 1
Brugia malayi cathepsin Z-like cysteine proteinase 0.0032 0.0261 0.0878
Brugia malayi hypothetical protein 0.0012 0.005 0.0168
Brugia malayi Papain family cysteine protease containing protein 0.0076 0.0707 0.2383
Plasmodium vivax importin-beta 2, putative 0.0035 0.0286 0.2087
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0032 0.0261 0.052
Loa Loa (eye worm) hypothetical protein 0.0029 0.0222 0.0592
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0261 0.1913
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0222 1
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0032 0.0261 0.1829
Entamoeba histolytica cysteine protease, putative 0.0076 0.0707 0.5142
Mycobacterium ulcerans hypothetical protein 0.0029 0.0222 1
Loa Loa (eye worm) hypothetical protein 0.0007 0.0002 0.0004
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0148 0.1072
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0012 0.005 0.0266
Echinococcus multilocularis voltage gated potassium channel 0.001 0.0034 0.0034
Onchocerca volvulus 0.014 0.1363 1
Brugia malayi Niemann-Pick C1 protein precursor 0.0119 0.115 0.3875
Plasmodium falciparum serine repeat antigen 2 0.0032 0.0261 0.1903
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0296 0.2969 0.5928
Echinococcus multilocularis Niemann Pick C1 protein 0.0119 0.115 0.115
Loa Loa (eye worm) hypothetical protein 0.0032 0.0261 0.0695
Entamoeba histolytica cysteine proteinase 2 0.0076 0.0707 0.5142
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0038 0.0076
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0714 0.1904
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0008 0.0061
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0014 0.0546
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.014 0.1363 1
Brugia malayi Cathepsin L-like precursor 0.0096 0.0916 0.3085
Toxoplasma gondii cathepsin CPC2 0.0032 0.0261 0.1903
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0032 0.0261 0.1913
Schistosoma mansoni cathepsin S (C01 family) 0.0032 0.0261 0.052
Leishmania major cathepsin L-like protease 0.014 0.1363 1
Echinococcus multilocularis cysteine protease 0.014 0.1363 0.1363
Loa Loa (eye worm) hypothetical protein 0.0021 0.0148 0.0393
Entamoeba histolytica hypothetical protein 0.0028 0.0218 0.1512
Brugia malayi TAR-binding protein 0.0076 0.0714 0.2406
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0076 0.0707 0.5142
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0032 0.0261 0.1913
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.005 0.0365
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0032 0.0261 0.1913
Toxoplasma gondii propionate-CoA ligase 0.0008 0.0014 0.009
Plasmodium falciparum serine repeat antigen 9 0.0032 0.0261 0.1903
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0008 0.0061
Brugia malayi Papain family cysteine protease containing protein 0.0032 0.0261 0.0878
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.3751 1
Echinococcus multilocularis cysteine protease 0.014 0.1363 0.1363
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0222 0.1542
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0014 0.0047
Brugia malayi Importin beta-1 subunit 0.0035 0.0286 0.0962
Giardia lamblia Cathepsin B precursor 0.0032 0.0261 0.2011
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0014 0.0047
Brugia malayi cathepsin L precursor 0.0032 0.0261 0.0878
Echinococcus multilocularis cathepsin l cysteine peptidase 0.014 0.1363 0.1363
Trypanosoma cruzi cruzipain precursor, putative 0.014 0.1363 0.4565
Onchocerca volvulus Cathepsin L homolog 0.014 0.1363 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0136 0.6071
Brugia malayi hypothetical protein 0.0012 0.005 0.0168
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0222 0.1542
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.014 0.1363 1
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0261 0.1913
Brugia malayi RNA binding protein 0.0076 0.0714 0.2406
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.014 0.1363 1
Loa Loa (eye worm) hypothetical protein 0.0119 0.115 0.3067
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0374 0.0374
Loa Loa (eye worm) hypothetical protein 0.0007 0.0002 0.0004
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0038 0.0038
Plasmodium vivax replication factor C subunit 1, putative 0.0012 0.005 0.0354
Entamoeba histolytica hypothetical protein 0.0032 0.0261 0.1829
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0008 0.0014 0.0546
Echinococcus granulosus importin subunit beta 1 0.0035 0.0286 0.057
Plasmodium falciparum serine repeat antigen 1 0.0032 0.0261 0.1903
Plasmodium vivax unspecified product 0.0032 0.0261 0.1903
Entamoeba histolytica cysteine proteinase, putative 0.0076 0.0707 0.5142
Loa Loa (eye worm) cathepsin B 0.0114 0.1098 0.2928
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.0603 0.4421
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0222 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.014 0.1363 1
Giardia lamblia Cathepsin B precursor 0.0114 0.1098 1
Schistosoma mansoni topbp1 0.0012 0.005 0.0099
Loa Loa (eye worm) hypothetical protein 0.0062 0.057 0.1521
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0043 0.0374 0.1261
Loa Loa (eye worm) hypothetical protein 0.0029 0.0222 0.0592
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0222 0.0748
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.014 0.1363 1
Entamoeba histolytica cysteine protease, putative 0.014 0.1363 1
Plasmodium falciparum importin beta, putative 0.0035 0.0286 0.2087
Loa Loa (eye worm) hypothetical protein 0.0012 0.005 0.0133
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0032 0.0261 0.1913
Echinococcus granulosus nibrin 0.0012 0.005 0.0099
Giardia lamblia Cysteine protease 0.0032 0.0261 0.2011
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.014 0.1363 1
Loa Loa (eye worm) hypothetical protein 0.0007 0.0002 0.0004
Loa Loa (eye worm) oxidoreductase 0.0008 0.0014 0.0037
Entamoeba histolytica cysteine protease, putative 0.0076 0.0707 0.5142
Echinococcus multilocularis nibrin 0.0012 0.005 0.005
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0714 0.1426
Echinococcus granulosus cathepsin L 0.0076 0.0707 0.1412
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0012 0.005 0.0365
Toxoplasma gondii cathepsin CPL 0.014 0.1363 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0261 0.0695
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0008 0.0014 0.0014
Giardia lamblia Cathepsin L precursor 0.0032 0.0261 0.2011
Onchocerca volvulus Cathepsin L homolog 0.014 0.1363 1
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0008 0.0061
Loa Loa (eye worm) hypothetical protein 0.0007 0.0002 0.0004
Schistosoma mansoni hypothetical protein 0.0372 0.3751 0.749
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0032 0.0261 0.2011
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0148 1
Brugia malayi Cathepsin L-like cysteine proteinase 0.0096 0.0916 0.3085
Brugia malayi CXXC zinc finger family protein 0.0035 0.0284 0.0957
Giardia lamblia Cysteine protease 0.0032 0.0261 0.2011
Echinococcus granulosus replication factor c subunit 1 0.0012 0.005 0.0099
Echinococcus granulosus Niemann Pick C1 protein 0.017 0.1675 0.3345
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0119 0.115 0.8426
Echinococcus granulosus tar DNA binding protein 0.0076 0.0714 0.1426
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.014 0.1363 1
Entamoeba histolytica cysteine protease, putative 0.0032 0.0261 0.1829
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0114 0.1098 0.2193
Schistosoma mansoni hypothetical protein 0.0049 0.0433 0.0865
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0296 0.2969 0.5928
Echinococcus granulosus sterol regulatory element binding protein 0.0051 0.0452 0.0903
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.005 0.0121
Brugia malayi Cathepsin L-like precursor 0.014 0.1363 0.459
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0222 1
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0296 0.2969 0.5928
Loa Loa (eye worm) hypothetical protein 0.0012 0.005 0.0133
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0008 0.0061
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0032 0.0261 0.1903
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.014 0.1363 1
Onchocerca volvulus 0.014 0.1363 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0016 0.0032
Loa Loa (eye worm) hypothetical protein 0.0051 0.0452 0.1206
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.014 0.1363 1
Entamoeba histolytica cysteine protease, putative 0.0076 0.0707 0.5142
Leishmania major cathepsin L-like protease 0.014 0.1363 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0033 0.027 0.1981
Loa Loa (eye worm) hypothetical protein 0.0012 0.005 0.0133
Brugia malayi Cathepsin L-like precursor 0.014 0.1363 0.459
Onchocerca volvulus 0.014 0.1363 1
Trypanosoma cruzi cysteine protease, putative 0.0076 0.0707 0.2347
Onchocerca volvulus 0.0008 0.0014 0.009
Echinococcus multilocularis protein patched 0.0051 0.0452 0.0452
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0032 0.0261 0.052
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.014 0.1363 1
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0114 0.1098 0.8039
Brugia malayi cathepsin B-like cysteine proteinase 0.0296 0.2969 1
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0014 0.0047
Schistosoma mansoni voltage-gated potassium channel 0.0039 0.0328 0.0654
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0032 0.0261 0.1913
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0032 0.0261 0.0695
Echinococcus multilocularis cathepsin L cysteine protease 0.014 0.1363 0.1363
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0374 0.0748
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.014 0.1363 1
Loa Loa (eye worm) hypothetical protein 0.0007 0.0002 0.0004
Entamoeba histolytica cysteine proteinase, putative 0.0096 0.0916 0.6687
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0008 0.0014 0.0546
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0012 0.005 0.0168
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0222 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.014 0.1363 1
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0008 0.0061
Brugia malayi CHE-14 protein 0.0051 0.0452 0.1524
Plasmodium falciparum cysteine proteinase falcipain 2a 0.014 0.1363 1
Echinococcus multilocularis cathepsin b 0.0296 0.2969 0.2969
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.014 0.1363 1
Leishmania major cathepsin L-like protease 0.014 0.1363 1
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0032 0.0261 0.1903
Loa Loa (eye worm) hypothetical protein 0.0007 0.0002 0.0004
Brugia malayi hypothetical protein 0.0007 0.0002 0.0006
Echinococcus multilocularis sterol regulatory element binding protein 0.0051 0.0452 0.0452
Echinococcus multilocularis cathepsin L cysteine protease 0.014 0.1363 0.1363
Loa Loa (eye worm) hypothetical protein 0.0012 0.005 0.0133
Trypanosoma cruzi FHA domain containing protein, putative 0.0012 0.005 0.0121
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.005 0.0365
Plasmodium falciparum serine repeat antigen 5 0.0032 0.0261 0.1903
Loa Loa (eye worm) hypothetical protein 0.0007 0.0002 0.0004
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.014 0.1363 1
Plasmodium vivax unspecified product 0.0043 0.0374 0.2738
Entamoeba histolytica cysteine protease, putative 0.0076 0.0707 0.5142
Loa Loa (eye worm) hypothetical protein 0.0021 0.0148 0.0393
Echinococcus granulosus cathepsin b 0.0296 0.2969 0.5928
Echinococcus granulosus Protein patched homolog 1 0.0051 0.0452 0.0903
Giardia lamblia Encystation-specific protease 0.0032 0.0261 0.2011
Brugia malayi Cathepsin L-like precursor 0.0096 0.0916 0.3085
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0714 0.1426
Brugia malayi Patched family protein 0.0007 0.0002 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0008 0.0061
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.014 0.1363 1
Plasmodium falciparum cysteine proteinase falcipain 2b 0.014 0.1363 1
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0032 0.0261 0.1913
Brugia malayi cathepsin L-like precursor 0.0096 0.0916 0.3085
Echinococcus granulosus cathepsin l cysteine peptidase 0.014 0.1363 0.2721
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0032 0.0261 0.2011
Echinococcus granulosus cathepsin L 0.0032 0.0261 0.052
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0008 0.0014 0.0037
Schistosoma mansoni cpg binding protein 0.0037 0.0305 0.0608
Echinococcus granulosus cathepsin b 0.0296 0.2969 0.5928
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0008 0.0061
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0008 0.0014 0.0546
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.014 0.1363 1
Brugia malayi hypothetical protein 0.0007 0.0002 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0008 0.0061
Loa Loa (eye worm) fibroinase 0.014 0.1363 0.3633
Brugia malayi Patched family protein 0.0007 0.0002 0.0006
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0036 0.0294 0.0587
Loa Loa (eye worm) hypothetical protein 0.0043 0.0374 0.0998
Loa Loa (eye worm) hypothetical protein 0.0007 0.0002 0.0004
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0008 0.0061
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0014 0.0047
Entamoeba histolytica cysteine protease, putative 0.0076 0.0707 0.5142
Trypanosoma cruzi cysteine proteinase, putative 0.0076 0.0707 0.2347
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.014 0.1363 1
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.005 0.0365
Onchocerca volvulus 0.014 0.1363 1
Onchocerca volvulus 0.0008 0.0014 0.009
Loa Loa (eye worm) hypothetical protein 0.0007 0.0002 0.0004
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.014 0.1363 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0008 0.0061
Plasmodium falciparum serine repeat antigen 8 0.0032 0.0261 0.1903
Echinococcus multilocularis cathepsin L 0.0076 0.0707 0.0707
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0014 0.0546
Brugia malayi Cathepsin L-like precursor 0.014 0.1363 0.459
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.014 0.1363 1
Brugia malayi Papain family cysteine protease containing protein 0.0076 0.0707 0.2383
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0222 0.1542
Brugia malayi protein C24B5.3 0.0007 0.0002 0.0006
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0012 0.005 0.0365
Entamoeba histolytica cysteine protease, putative 0.0076 0.0707 0.5142
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0032 0.0261 0.052
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.001 0.0034 0.0034
Trypanosoma cruzi major cysteine proteinase, putative 0.0032 0.0261 0.0835
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.014 0.1363 1
Schistosoma mansoni patched 1 0.0051 0.0452 0.0903
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0032 0.0261 0.0695
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0714 0.1904
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.014 0.1363 1
Loa Loa (eye worm) hypothetical protein 0.0007 0.0002 0.0004
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.014 0.1363 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0008 0.0061
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.014 0.1363 1
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0036 0.0294 0.0784
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0008 0.0061
Trypanosoma cruzi cysteine peptidase, putative 0.014 0.1363 0.4565
Echinococcus granulosus cysteine protease 0.0076 0.0707 0.1412
Giardia lamblia Cathepsin L precursor 0.0032 0.0261 0.2011
Toxoplasma gondii ATPase, AAA family protein 0.0012 0.005 0.0354
Schistosoma mansoni cathepsin B (C01 family) 0.0032 0.0261 0.052
Entamoeba histolytica hypothetical protein 0.0043 0.0374 0.2672
Loa Loa (eye worm) hypothetical protein 0.0021 0.0148 0.0393
Giardia lamblia Cathepsin B precursor 0.0114 0.1098 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0032 0.0261 0.1913
Loa Loa (eye worm) patched family protein 0.0007 0.0002 0.0004
Onchocerca volvulus 0.014 0.1363 1
Entamoeba histolytica hypothetical protein 0.0043 0.0374 0.2672
Schistosoma mansoni cathepsin F (C01 family) 0.014 0.1363 0.2721
Brugia malayi cathepsin Z-like cysteine proteinase 0.0032 0.0261 0.0878
Schistosoma mansoni cpg binding protein 0.0037 0.0305 0.0608
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0222 0.1542
Plasmodium vivax vivapain-2 0.014 0.1363 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0136 0.6071
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0008 0.0061
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0014 0.0047
Plasmodium falciparum cysteine proteinase falcipain 3 0.014 0.1363 1
Echinococcus multilocularis protein dispatched 1 0.0058 0.0526 0.0526
Giardia lamblia Cathepsin B precursor 0.0032 0.0261 0.2011
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0148 0.6421
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0012 0.005 0.0266
Loa Loa (eye worm) hypothetical protein 0.0007 0.0002 0.0004
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0076 0.0707 0.5191
Loa Loa (eye worm) hypothetical protein 0.0096 0.0916 0.2442
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0008 0.0014 0.0546
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.005 0.0365
Loa Loa (eye worm) hypothetical protein 0.0031 0.0246 0.0655
Loa Loa (eye worm) hypothetical protein 0.001 0.0034 0.009
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0714 0.1426
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0032 0.0261 0.2011
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0032 0.0261 0.1913
Leishmania major importin beta-1 subunit, putative 0.0028 0.0218 0.1512
Brugia malayi Myosin head containing protein 0.0007 0.0002 0.0006
Echinococcus multilocularis expressed conserved protein 0.0112 0.1076 0.1076
Loa Loa (eye worm) hypothetical protein 0.0096 0.0916 0.2442
Plasmodium vivax unspecified product 0.0076 0.0707 0.5185
Treponema pallidum DNA ligase (lig) 0.0012 0.005 0.5
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0222 1
Brugia malayi Patched protein homolog 1 0.0007 0.0002 0.0006
Entamoeba histolytica cysteine proteinase, putative 0.014 0.1363 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.014 0.1363 1
Loa Loa (eye worm) hypothetical protein 0.0007 0.0002 0.0004
Brugia malayi Papain family cysteine protease containing protein 0.0032 0.0261 0.0878
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0008 0.0061
Echinococcus granulosus cathepsin l1 0.0096 0.0916 0.1829
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0222 1
Trypanosoma cruzi cysteine peptidase, putative 0.014 0.1363 0.4565
Brugia malayi Patched family protein 0.0007 0.0002 0.0006
Brugia malayi cathepsin L-like cysteine proteinase 0.0032 0.0261 0.0878
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0032 0.0261 0.1903
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0218 0.069
Trypanosoma cruzi major cysteine proteinase, putative 0.0032 0.0261 0.0835
Loa Loa (eye worm) hypothetical protein 0.0007 0.0002 0.0004
Trichomonas vaginalis antibiotic synthetase, putative 0.0008 0.0014 0.0102
Leishmania major cathepsin L-like protease 0.014 0.1363 1
Brugia malayi Patched family protein 0.0007 0.0002 0.0006
Loa Loa (eye worm) cysteine protease 0.014 0.1363 0.3633
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0036 0.0294 0.0294
Trypanosoma brucei cysteine peptidase C (CPC) 0.0114 0.1098 0.8039
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0032 0.0261 0.0695
Loa Loa (eye worm) hypothetical protein 0.0012 0.005 0.0133
Onchocerca volvulus 0.014 0.1363 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0296 0.2969 0.5928
Schistosoma mansoni hypothetical protein 0.0049 0.0433 0.0865
Plasmodium vivax serine-repeat antigen (SERA) 0.0032 0.0261 0.1903
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0032 0.0261 0.1913
Brugia malayi Cathepsin L-like precursor 0.014 0.1363 0.459
Entamoeba histolytica hypothetical protein 0.0012 0.005 0.0266
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0261 0.1913
Schistosoma mansoni topbp1 0.0012 0.005 0.0099
Schistosoma mansoni cathepsin s 0.0043 0.0374 0.0747
Echinococcus granulosus expressed conserved protein 0.0112 0.1076 0.2149
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0012 0.005 0.0365
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0096 0.0916 0.3053
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0008 0.0014 0.0028
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0076 0.0707 0.1412
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0032 0.0261 0.2011
Entamoeba histolytica cysteine protease, putative 0.0076 0.0707 0.5142
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0076 0.0707 0.1412
Loa Loa (eye worm) RNA binding protein 0.0076 0.0714 0.1904
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0032 0.0261 0.1913
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0136 0.6071
Loa Loa (eye worm) hypothetical protein 0.0008 0.0014 0.0037
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0714 0.0714
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.001 0.0034 0.0113
Loa Loa (eye worm) hypothetical protein 0.0029 0.0222 0.0592
Toxoplasma gondii preprocathepsin c precursor, putative 0.0032 0.0261 0.1903
Giardia lamblia Cathepsin B precursor 0.0032 0.0261 0.2011
Giardia lamblia Cathepsin L precursor 0.0032 0.0261 0.2011
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0286 0.0286
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0012 0.005 0.0365
Brugia malayi fibroinase precursor 0.0032 0.0261 0.0878
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0284 0.0758
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.0684 0.1366
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0218 0.1599
Loa Loa (eye worm) hypothetical protein 0.0007 0.0002 0.0004
Leishmania major cathepsin L-like protease 0.014 0.1363 1
Schistosoma mansoni chromosome transmission fidelity factor 0.0012 0.005 0.0099
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.014 0.1363 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0261 0.0695
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0222 0.1542
Loa Loa (eye worm) hypothetical protein 0.0032 0.0261 0.0695
Onchocerca volvulus 0.0035 0.0284 0.2076
Loa Loa (eye worm) hypothetical protein 0.0007 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0021 0.0148 0.0393
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0032 0.0261 0.1903
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0008 0.0014 0.009
Brugia malayi Patched related family protein 4 0.0007 0.0002 0.0006
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0032 0.0261 0.1903
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0032 0.0261 0.0878
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0136 0.6071
Trypanosoma cruzi cysteine peptidase, putative 0.0076 0.0707 0.2347
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.005 0.0121
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.014 0.1363 1
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0014 0.0546
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0008 0.0014 0.009
Loa Loa (eye worm) patched family protein 0.0007 0.0002 0.0004
Schistosoma mansoni acetyl-CoA synthetase 0.0008 0.0014 0.0028
Onchocerca volvulus 0.0012 0.005 0.0354
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0286 0.2087
Loa Loa (eye worm) patched family protein 0.0007 0.0002 0.0004
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0032 0.0261 0.052
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0032 0.0261 0.1903
Brugia malayi Patched related family protein 12 0.0007 0.0002 0.0006
Entamoeba histolytica cysteine proteinase, putative 0.0076 0.0707 0.5142
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0043 0.0374 0.0998
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0296 0.2969 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0008 0.0061
Giardia lamblia Cathepsin L precursor 0.0032 0.0261 0.2011
Brugia malayi Patched family protein 0.0007 0.0002 0.0006
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0076 0.0707 0.5142
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0714 0.2406
Loa Loa (eye worm) hypothetical protein 0.0007 0.0002 0.0004
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0714 0.1426
Loa Loa (eye worm) hypothetical protein 0.0007 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0007 0.0002 0.0004
Schistosoma mansoni cathepsin F (C01 family) 0.014 0.1363 0.2721
Entamoeba histolytica cysteine protease, putative 0.0032 0.0261 0.1829
Brugia malayi Patched family protein 0.0007 0.0002 0.0006
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.0012 0.005 0.1722
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0032 0.0261 0.1903
Echinococcus multilocularis replication factor c subunit 1 0.0012 0.005 0.005
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0261 0.1913
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0016 0.0032
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0148 0.6617
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.005 0.0365
Echinococcus granulosus mixed lineage leukemia protein mll 0.0009 0.0016 0.0032
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0036 0.0123
Loa Loa (eye worm) hypothetical protein 0.0007 0.0002 0.0004
Entamoeba histolytica cysteine protease, putative 0.0032 0.0261 0.1829
Giardia lamblia Cathepsin B precursor 0.0032 0.0261 0.2011
Loa Loa (eye worm) hypothetical protein 0.0007 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0007 0.0002 0.0004
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0222 1
Loa Loa (eye worm) hypothetical protein 0.0007 0.0002 0.0004
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0032 0.0261 0.1903
Loa Loa (eye worm) hypothetical protein 0.0032 0.0261 0.0695
Echinococcus granulosus cpg binding protein 0.0037 0.0305 0.0608
Brugia malayi Papain family cysteine protease containing protein 0.0032 0.0261 0.0878
Loa Loa (eye worm) hypothetical protein 0.0007 0.0002 0.0004
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0008 0.0014 0.0546
Brugia malayi Pax transcription activation domain interacting protein 0.0012 0.005 0.0168
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0261 0.1913
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.014 0.1363 1
Schistosoma mansoni voltage-gated potassium channel 0.001 0.0034 0.0067
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0076 0.0707 0.2347
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0032 0.0261 0.1903
Brugia malayi Patched family protein 0.0007 0.0002 0.0006
Loa Loa (eye worm) patched family protein 0.0007 0.0002 0.0004
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0038 0.0101
Entamoeba histolytica cysteine protease, putative 0.0076 0.0707 0.5142
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0009 0.0016 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0008 0.0061
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0008 0.0014 0.0546
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.014 0.1363 1
Giardia lamblia Cathepsin L precursor 0.0032 0.0261 0.2011
Echinococcus granulosus cathepsin l1 0.014 0.1363 0.2721
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0032 0.0261 0.052
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0114 0.1098 0.8059
Trypanosoma cruzi cysteine proteinase, putative 0.0076 0.0707 0.2347
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0148 0.1072
Schistosoma mansoni hypothetical protein 0.0494 0.5008 1
Brugia malayi topoisomerase 0.0012 0.005 0.0168
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0222 0.0748
Leishmania major cathepsin L-like protease 0.014 0.1363 1
Brugia malayi hypothetical protein 0.0007 0.0002 0.0006
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0261 0.1913
Brugia malayi Cathepsin L-like precursor 0.014 0.1363 0.459
Leishmania major cathepsin L-like protease 0.014 0.1363 1
Brugia malayi Cathepsin L-like precursor 0.014 0.1363 0.459
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.0012 0.005 0.1722
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0032 0.0261 0.1903
Plasmodium vivax acetyl-CoA synthetase, putative 0.0008 0.0014 0.009
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0076 0.0707 0.5191
Onchocerca volvulus 0.0096 0.0916 0.6717
Onchocerca volvulus 0.0032 0.0261 0.1903
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0374 0.0748
Onchocerca volvulus Cathepsin L homolog 0.0032 0.0261 0.1903
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0008 0.0061
Loa Loa (eye worm) ctsf protein 0.014 0.1363 0.3633
Schistosoma mansoni DNA ligase IV 0.0012 0.005 0.0099
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0032 0.0261 0.1903
Entamoeba histolytica hypothetical protein 0.0043 0.0374 0.2672
Brugia malayi Patched family protein 0.0007 0.0002 0.0006
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0286 0.2015
Giardia lamblia Cathepsin L-like protease 0.0032 0.0261 0.2011
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0121 0.1169 0.2335
Schistosoma mansoni voltage-gated potassium channel 0.001 0.0034 0.0067
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0016 0.0016
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0008 0.0014 0.009
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0076 0.0707 0.1412
Plasmodium falciparum cysteine proteinase falcipain 1 0.0076 0.0707 0.5185
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0032 0.0261 0.052
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.014 0.1363 1
Brugia malayi hypothetical protein 0.0043 0.0374 0.1261
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0051 0.0452 0.1206
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0012 0.005 0.0121
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0008 0.0014 0.0047
Echinococcus multilocularis cathepsin L 0.0032 0.0261 0.0261
Entamoeba histolytica cysteine protease, putative 0.0032 0.0261 0.1829
Giardia lamblia Cathepsin B precursor 0.0032 0.0261 0.2011
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.014 0.1363 1
Schistosoma mansoni cpg binding protein 0.0035 0.0284 0.0567
Entamoeba histolytica cysteine protease, putative 0.0076 0.0707 0.5142
Trichomonas vaginalis replication factor C large subunit, putative 0.0012 0.005 0.0365
Loa Loa (eye worm) hypothetical protein 0.0032 0.0261 0.0695
Trichomonas vaginalis antibiotic synthetase, putative 0.0008 0.0014 0.0102
Plasmodium vivax vivapain-2 0.014 0.1363 1
Entamoeba histolytica cysteine proteinase, putative 0.0076 0.0707 0.5142
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0032 0.0261 0.052
Brugia malayi Patched family protein 0.0007 0.0002 0.0006
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.0012 0.005 0.5
Loa Loa (eye worm) hypothetical protein 0.0007 0.0002 0.0004
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0218 0.1599
Plasmodium vivax vivapain-1 0.0076 0.0707 0.5185
Trypanosoma cruzi cysteine peptidase, putative 0.014 0.1363 0.4565
Entamoeba histolytica cysteine proteinase, putative 0.014 0.1363 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0222 0.1542
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0261 0.1913
Brugia malayi protein C24B5.3 0.0007 0.0002 0.0006
Entamoeba histolytica cysteine protease, putative 0.0032 0.0261 0.1829
Giardia lamblia Cathepsin L-like protease 0.0032 0.0261 0.2011
Echinococcus granulosus snurportin 1 0.0372 0.3751 0.749
Brugia malayi Patched family protein 0.0007 0.0002 0.0006
Loa Loa (eye worm) hypothetical protein 0.0007 0.0002 0.0004
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.014 0.1363 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0286 0.2015
Trypanosoma cruzi cysteine peptidase, putative 0.0043 0.0374 0.1219
Entamoeba histolytica cysteine protease, putative 0.0032 0.0261 0.1829
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0008 0.0014 0.0037
Brugia malayi cathepsin F-like cysteine proteinase 0.0032 0.0261 0.0878
Plasmodium falciparum replication factor C subunit 1, putative 0.0012 0.005 0.0354
Brugia malayi Papain family cysteine protease containing protein 0.014 0.1363 0.459
Echinococcus multilocularis cpg binding protein 0.0037 0.0305 0.0305
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0222 1
Giardia lamblia Cysteine protease 0.0032 0.0261 0.2011
Plasmodium falciparum serine repeat antigen 4 0.0032 0.0261 0.1903
Brugia malayi Patched family protein 0.0007 0.0002 0.0006
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0714 0.1426
Loa Loa (eye worm) hypothetical protein 0.0296 0.2969 0.7914
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0222 1
Trichomonas vaginalis helicase, putative 0.0008 0.0008 0.0061
Brugia malayi Patched family protein 0.0007 0.0002 0.0006
Entamoeba histolytica cysteine protease, putative 0.0076 0.0707 0.5142
Entamoeba histolytica cysteine protease, putative 0.0076 0.0707 0.5142
Plasmodium falciparum serine repeat antigen 7 0.0032 0.0261 0.1903
Entamoeba histolytica cysteine proteinase, putative 0.0076 0.0707 0.5142
Entamoeba histolytica hypothetical protein 0.0043 0.0374 0.2672
Brugia malayi Cathepsin L-like precursor 0.0043 0.0374 0.1261
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0032 0.0261 0.1903
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0096 0.0916 0.6721
Loa Loa (eye worm) hypothetical protein 0.014 0.1363 0.3633
Plasmodium falciparum serine repeat antigen 6 0.0032 0.0261 0.1903
Echinococcus granulosus Niemann Pick C1 protein 0.0119 0.115 0.2297
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0261 0.1913
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0032 0.0261 0.052
Loa Loa (eye worm) hypothetical protein 0.0007 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0043 0.0374 0.0998
Echinococcus multilocularis snurportin 1 0.0372 0.3751 0.3751
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0096 0.0916 0.6721
Loa Loa (eye worm) hypothetical protein 0.0007 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0012 0.005 0.0133
Leishmania major cysteine peptidase A (CPA) 0.014 0.1363 1
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0014 0.0546
Echinococcus multilocularis cathepsin b 0.0296 0.2969 0.2969
Trypanosoma cruzi cysteine peptidase, putative 0.014 0.1363 0.4565
Brugia malayi DKFZp564C0469 protein 0.0012 0.005 0.0168
Brugia malayi RNA, U transporter 1 0.0099 0.0946 0.3187
Giardia lamblia Cathepsin B precursor 0.0114 0.1098 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0218 0.1599
Schistosoma mansoni hypothetical protein 0.0049 0.0433 0.0865
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0032 0.0261 0.1829
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0033 0.027 0.1981
Giardia lamblia Hypothetical protein 0.0032 0.0261 0.2011
Brugia malayi Patched family protein 0.0007 0.0002 0.0006
Trypanosoma cruzi cruzipain precursor, putative 0.0043 0.0374 0.1219
Brugia malayi cathepsin F-like cysteine proteinase 0.0043 0.0374 0.1261
Entamoeba histolytica cysteine protease, putative 0.0076 0.0707 0.5142
Leishmania major cathepsin L-like protease 0.014 0.1363 1
Onchocerca volvulus Cathepsin F homolog 0.014 0.1363 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.014 0.1363 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.014 0.1363 0.3633
Echinococcus multilocularis cathepsin l cysteine peptidase 0.014 0.1363 0.1363
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.014 0.1363 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0286 0.0761
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.014 0.1363 1
Entamoeba histolytica cysteine proteinase 1, putative 0.0076 0.0707 0.5142
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0032 0.0261 0.1913
Echinococcus granulosus cathepsin L cysteine proteinase 0.014 0.1363 0.2721
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0008 0.0014 0.0546
Plasmodium falciparum serine repeat antigen 3 0.0032 0.0261 0.1903
Giardia lamblia Hypothetical protein 0.0032 0.0261 0.2011
Loa Loa (eye worm) patched family protein 0.0007 0.0002 0.0004
Plasmodium vivax serine-repeat antigen (SERA) 0.0032 0.0261 0.1903
Loa Loa (eye worm) hypothetical protein 0.0008 0.0014 0.0037
Giardia lamblia Cathepsin L precursor 0.0032 0.0261 0.2011
Schistosoma mansoni hypothetical protein 0.0049 0.0433 0.0865
Brugia malayi Patched family protein 0.0007 0.0002 0.0006
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0222 0.0748
Toxoplasma gondii cathepsin B 0.0114 0.1098 0.8057
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0012 0.005 0.0354
Loa Loa (eye worm) hypothetical protein 0.0043 0.0374 0.0998
Toxoplasma gondii cathepsin CPC1 0.0032 0.0261 0.1903
Echinococcus granulosus voltage gated potassium channel 0.001 0.0034 0.0067
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.014 0.1363 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0114 0.1098 0.3669
Onchocerca volvulus 0.0008 0.0014 0.009
Loa Loa (eye worm) hypothetical protein 0.0007 0.0002 0.0004
Echinococcus multilocularis Niemann Pick C1 protein 0.017 0.1675 0.1675
Loa Loa (eye worm) hypothetical protein 0.0007 0.0002 0.0004
Schistosoma mansoni cathepsin F (C01 family) 0.0096 0.0916 0.1829
Schistosoma mansoni importin beta-1 0.0035 0.0286 0.057
Loa Loa (eye worm) hypothetical protein 0.0096 0.0916 0.2442
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0032 0.0261 0.052
Plasmodium vivax vivapain-3 0.0076 0.0707 0.5185
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0036 0.0294 0.099
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0222 1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.001 0.0034 0.0067
Entamoeba histolytica cysteine protease, putative 0.0076 0.0707 0.5142
Loa Loa (eye worm) hypothetical protein 0.0021 0.0148 0.0393
Schistosoma mansoni voltage-gated potassium channel 0.0039 0.0328 0.0654
Brugia malayi Patched related family protein 10 0.0007 0.0002 0.0006
Schistosoma mansoni cathepsin C 0.0032 0.0261 0.052
Echinococcus granulosus dnaJ subfamily B 0.0494 0.5008 1
Giardia lamblia Cysteine protease 0.0032 0.0261 0.2011
Loa Loa (eye worm) hypothetical protein 0.0007 0.0002 0.0004
Onchocerca volvulus 0.0008 0.0014 0.009
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.5008 0.5008
Schistosoma mansoni hypothetical protein 0.0043 0.0374 0.0748
Loa Loa (eye worm) hypothetical protein 0.0007 0.0002 0.0004

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 64.418 um PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Response HTS to Identify Activators of 5'UTR Stem-Loop Driven Prion Protein mRNA Translation in H4 Neuroglioblastoma Cells. (Class of assay: confirmatory) [Related pubchem assays: 1829 (Project Summary), 1814 (Primary HTS)] ChEMBL. No reference
Potency (functional) 2.3934 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 3.2629 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 4.4668 um PUBCHEM_BIOASSAY: qHTS Assay for NPC1 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 4.6109 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 5.6234 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 5.8584 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 6.5733 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 8.9125 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.575 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 17.7828 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 50.1187 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) = 112.2018 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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