Detailed information for compound 1389051

Basic information

Technical information
  • TDR Targets ID: 1389051
  • Name: 3-chloro-1-(3,4-dichlorophenyl)-4-[4-(2-fluor ophenyl)piperazin-1-yl]pyrrole-2,5-dione
  • MW: 454.709 | Formula: C20H15Cl3FN3O2
  • H donors: 0 H acceptors: 2 LogP: 5.16 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1N(c2ccc(c(c2)Cl)Cl)C(=O)C(=C1N1CCN(CC1)c1ccccc1F)Cl
  • InChi: 1S/C20H15Cl3FN3O2/c21-13-6-5-12(11-14(13)22)27-19(28)17(23)18(20(27)29)26-9-7-25(8-10-26)16-4-2-1-3-15(16)24/h1-6,11H,7-10H2
  • InChiKey: RXHYBFNIXYPZFU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-chloro-1-(3,4-dichlorophenyl)-4-[4-(2-fluorophenyl)-1-piperazinyl]pyrrole-2,5-dione
  • 3-chloro-1-(3,4-dichlorophenyl)-4-[4-(2-fluorophenyl)piperazin-1-yl]-3-pyrroline-2,5-quinone
  • MLS-0090861.0001

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0056 0.0045 0.0052
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0056 0.0045 0.0052
Echinococcus multilocularis expressed protein 0.0587 0.1528 0.1827
Echinococcus granulosus retinal guanylyl cyclase 2 0.0056 0.0045 0.0052
Echinococcus granulosus FERM and pleckstrin domain containing protein 0.0054 0.0039 0.0046
Loa Loa (eye worm) RhoGEF domain-containing protein 0.0054 0.0039 0.0039
Echinococcus granulosus tyrosine protein kinase Blk 0.0056 0.0045 0.0052
Echinococcus granulosus Arf GAP and Pleckstrin domain containing protein 0.0054 0.0039 0.0046
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.0045 0.0036
Trichomonas vaginalis conserved hypothetical protein 0.0587 0.1528 1
Brugia malayi serine/threonine protein kinase 6 0.0075 0.0099 0.0099
Echinococcus multilocularis transfer RNA-Thr 0.0056 0.0045 0.0052
Loa Loa (eye worm) hypothetical protein 0.0587 0.1528 0.1528
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0166 0.0352 0.0352
Echinococcus granulosus tyrosine protein kinase Fyn 0.0056 0.0045 0.0052
Loa Loa (eye worm) TK/FER protein kinase 0.0056 0.0045 0.0045
Schistosoma mansoni serine/threonine protein kinase 0.0075 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0054 0.0039 0.0039
Loa Loa (eye worm) TK protein kinase 0.0056 0.0045 0.0045
Trichomonas vaginalis AGC family protein kinase 0.0068 0.008 0.0274
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0045 0.0036
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0056 0.0045 0.0045
Trichomonas vaginalis protein tyrosine kinase, putative 0.0056 0.0045 0.0036
Entamoeba histolytica protein kinase, putative 0.0056 0.0045 0.0036
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0045 0.0036
Onchocerca volvulus 0.0056 0.0045 0.0023
Loa Loa (eye worm) hypothetical protein 0.011 0.0197 0.0197
Loa Loa (eye worm) uncoordinated protein 104 0.0054 0.0039 0.0039
Echinococcus granulosus activated cdc42 kinase 1 0.0056 0.0045 0.0052
Plasmodium falciparum protein kinase, putative 0.007 0.0085 0.7756
Trichomonas vaginalis AGC family protein kinase 0.0068 0.008 0.0274
Loa Loa (eye worm) hypothetical protein 0.0587 0.1528 0.1528
Plasmodium vivax tyrosine kinase-like protein, putative 0.0056 0.0045 0.0894
Echinococcus granulosus oxysterol binding protein 9 0.0054 0.0039 0.0046
Entamoeba histolytica protein kinase, putative 0.0056 0.0045 0.0036
Entamoeba histolytica serine/threonine kinase, putative 0.0056 0.0045 0.0036
Schistosoma mansoni dynamin 0.0054 0.0039 0.0039
Schistosoma mansoni tyrosine kinase 0.0056 0.0045 0.0045
Brugia malayi Regulator of G protein signaling domain containing protein 0.0587 0.1528 0.1528
Schistosoma mansoni tyrosine kinase 0.0056 0.0045 0.0045
Brugia malayi hypothetical protein 0.0587 0.1528 0.1528
Trypanosoma cruzi aurora B kinase, putative 0.0075 0.0099 1
Entamoeba histolytica serine/threonine kinase, putative 0.0056 0.0045 0.0036
Echinococcus multilocularis hypothetical protein 0.0369 0.092 0.1099
Echinococcus multilocularis epidermal growth factor receptor 0.0056 0.0045 0.0052
Schistosoma mansoni voltage-gated potassium channel 0.0044 0.0012 0.0012
Trichomonas vaginalis AGC family protein kinase 0.0075 0.0099 0.04
Echinococcus granulosus expressed protein 0.0587 0.1528 0.1827
Brugia malayi Plekhf2 protein 0.0054 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0058 0.0051 0.0051
Schistosoma mansoni dynamin 0.0054 0.0039 0.0039
Loa Loa (eye worm) TK/EGFR protein kinase 0.0056 0.0045 0.0045
Toxoplasma gondii protein kinase 0.0056 0.0045 0.0894
Trichomonas vaginalis AGC family protein kinase 0.0068 0.008 0.0274
Loa Loa (eye worm) hypothetical protein 0.0369 0.092 0.092
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0045 0.0036
Schistosoma mansoni serine/threonine-protein kinase 0.0068 0.008 0.008
Echinococcus multilocularis axis inhibition protein axin 0.0587 0.1528 0.1827
Entamoeba histolytica hypothetical protein 0.0068 0.008 0.0274
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0056 0.0045 0.0052
Brugia malayi Variant SH3 domain containing protein 0.0054 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0162 0.0341 0.0341
Schistosoma mansoni tyrosine kinase 0.0056 0.0045 0.0045
Trichomonas vaginalis AGC family protein kinase 0.0068 0.008 0.0274
Entamoeba histolytica protein kinase domain containing protein 0.0056 0.0045 0.0036
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0045 0.0036
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.007 0.0085 0.7756
Schistosoma mansoni hypothetical protein 0.0501 0.1288 0.1288
Echinococcus multilocularis regulator of G protein signaling 0.0587 0.1528 0.1827
Echinococcus multilocularis protein tyrosine kinase 0.0056 0.0045 0.0052
Echinococcus multilocularis tyrosine kinase 0.0056 0.0045 0.0052
Schistosoma mansoni tyrosine kinase 0.0056 0.0045 0.0045
Echinococcus multilocularis receptor type guanylyl cyclase 0.0056 0.0045 0.0052
Loa Loa (eye worm) hypothetical protein 0.0054 0.0039 0.0039
Onchocerca volvulus 0.0056 0.0045 0.0023
Loa Loa (eye worm) syntrophin-1 0.0054 0.0039 0.0039
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.007 0.0085 0.7756
Loa Loa (eye worm) TK/Met protein kinase 0.0056 0.0045 0.0045
Echinococcus granulosus beta 1 syntrophin 0.0054 0.0039 0.0046
Onchocerca volvulus 0.0056 0.0045 0.0023
Echinococcus multilocularis cytohesin 1 0.0054 0.0039 0.0046
Echinococcus granulosus twitchin 0.0125 0.0237 0.0282
Brugia malayi serine/threonine-protein kinase 6 0.0075 0.0099 0.0099
Schistosoma mansoni tyrosine kinase 0.0056 0.0045 0.0045
Entamoeba histolytica receptor protein kinase, putative 0.0056 0.0045 0.0036
Echinococcus granulosus tyrosine kinase 0.0056 0.0045 0.0052
Loa Loa (eye worm) hypothetical protein 0.0056 0.0045 0.0045
Loa Loa (eye worm) TK/CSK protein kinase 0.0056 0.0045 0.0045
Loa Loa (eye worm) cytohesin 3 0.0054 0.0039 0.0039
Trichomonas vaginalis conserved hypothetical protein 0.0162 0.0341 0.2024
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0056 0.0045 0.0036
Brugia malayi IPT/TIG domain containing protein 0.0162 0.0341 0.0341
Plasmodium vivax calcium-dependent protein kinase 7, putative 0.0068 0.008 0.6862
Schistosoma mansoni tyrosine kinase 0.0056 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0056 0.0045 0.0045
Trypanosoma brucei serine/threonine-protein kinase NrkA 0.0068 0.008 0.6862
Onchocerca volvulus 0.0056 0.0045 0.0023
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0045 0.0036
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0056 0.0045 0.0036
Loa Loa (eye worm) hypothetical protein 0.011 0.0197 0.0197
Echinococcus multilocularis Pleckstrin y 0.0054 0.0039 0.0046
Brugia malayi PH domain containing protein 0.0054 0.0039 0.0039
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0045 0.0036
Echinococcus granulosus receptor type guanylyl cyclase 0.0056 0.0045 0.0052
Schistosoma mansoni guanyl-nucleotide exchange factor 0.0054 0.0039 0.0039
Brugia malayi Protein kinase domain containing protein 0.0056 0.0045 0.0045
Brugia malayi serine/threonine kinase 12 0.0075 0.0099 0.0099
Schistosoma mansoni hypothetical protein 0.0054 0.0039 0.0039
Echinococcus granulosus tyrosine protein kinase ABL1 0.0056 0.0045 0.0052
Schistosoma mansoni tyrosine kinase 0.0056 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0369 0.092 0.092
Echinococcus multilocularis regulator of G protein signaling 3 0.0587 0.1528 0.1827
Echinococcus granulosus tyrosine protein kinase csk 0.0056 0.0045 0.0052
Echinococcus multilocularis pleckstrin y domain containing family A 0.0054 0.0039 0.0046
Brugia malayi Receptor family ligand binding region containing protein 0.0056 0.0045 0.0045
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0056 0.0045 0.0045
Brugia malayi Immunoglobulin I-set domain containing protein 0.0056 0.0045 0.0045
Brugia malayi regulator of G-protein signaling rgs-7 0.0587 0.1528 0.1528
Trichomonas vaginalis AGC family protein kinase 0.0068 0.008 0.0274
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.2774 0.7639 0.7639
Loa Loa (eye worm) SRC-1 0.0056 0.0045 0.0045
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0056 0.0045 0.0045
Loa Loa (eye worm) TK/FER protein kinase 0.0056 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0501 0.1288 0.1288
Echinococcus multilocularis semaphorin 5B 0.0369 0.092 0.1099
Echinococcus multilocularis Immunoglobulin 0.011 0.0197 0.0234
Trichomonas vaginalis conserved hypothetical protein 0.0587 0.1528 1
Trichomonas vaginalis AGC family protein kinase 0.0068 0.008 0.0274
Loa Loa (eye worm) TK/FER protein kinase 0.0056 0.0045 0.0045
Brugia malayi hypothetical protein 0.0587 0.1528 0.1528
Echinococcus multilocularis activin receptor type 0.007 0.0085 0.0101
Onchocerca volvulus Tyrosine kinase receptor Cad96Ca homolog 0.0056 0.0045 0.0023
Schistosoma mansoni semaphorin 5-related 0.0369 0.092 0.092
Echinococcus multilocularis calcium dependent secretion activator 1 0.0054 0.0039 0.0046
Echinococcus granulosus Rho GTPase activating protein 24 0.0054 0.0039 0.0046
Echinococcus multilocularis kinase suppressor of Ras 1 0.0056 0.0045 0.0052
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0056 0.0045 0.0052
Echinococcus multilocularis roundabout 2 0.0115 0.021 0.025
Brugia malayi hypothetical protein 0.0054 0.0039 0.0039
Echinococcus granulosus plexin a4 0.1032 0.2771 0.3313
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0056 0.0045 0.0052
Entamoeba histolytica protein kinase domain containing protein 0.0056 0.0045 0.0036
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0045 0.0036
Entamoeba histolytica hypothetical protein 0.0162 0.0341 0.2024
Schistosoma mansoni axis inhibition protein axin 0.0587 0.1528 0.1528
Echinococcus granulosus DCC interacting protein 13 beta 0.0054 0.0039 0.0046
Leishmania major protein kinase, putative 0.007 0.0085 0.7756
Schistosoma mansoni axis inhibition protein axin 0.0587 0.1528 0.1528
Leishmania major folate/biopterin transporter, putative 0.0068 0.008 0.6862
Leishmania major hypothetical protein, conserved 0.0056 0.0045 0.0894
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0045 0.0036
Echinococcus granulosus tyrosine protein kinase pr2 0.0056 0.0045 0.0052
Trichomonas vaginalis AGC family protein kinase 0.0068 0.008 0.0274
Trypanosoma brucei protein kinase, putative 0.0068 0.008 0.6862
Brugia malayi Protein kinase domain containing protein 0.0056 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0056 0.0045 0.0045
Entamoeba histolytica protein kinase domain containing protein 0.0056 0.0045 0.0036
Brugia malayi Protein kinase domain containing protein 0.0056 0.0045 0.0045
Loa Loa (eye worm) TK protein kinase 0.0056 0.0045 0.0045
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0162 0.0341 0.2024
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0056 0.0045 0.0052
Brugia malayi Cytohesin 3 0.0054 0.0039 0.0039
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0056 0.0045 0.0052
Schistosoma mansoni tyrosine kinase 0.0056 0.0045 0.0045
Entamoeba histolytica hypothetical protein 0.0056 0.0045 0.0036
Trichomonas vaginalis conserved hypothetical protein 0.0587 0.1528 1
Brugia malayi GTP-ase activating protein for Arf containing protein 0.0054 0.0039 0.0039
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0056 0.0045 0.0052
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0056 0.0045 0.0036
Schistosoma mansoni z-protein (S1r protein) 0.0587 0.1528 0.1528
Entamoeba histolytica protein kinase, putative 0.0056 0.0045 0.0036
Loa Loa (eye worm) sema domain-containing protein 0.0369 0.092 0.092
Brugia malayi Protein kinase domain containing protein 0.0056 0.0045 0.0045
Schistosoma mansoni serine/threonine protein kinase 0.2774 0.7639 0.7639
Schistosoma mansoni plexin 0.0501 0.1288 0.1288
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.007 0.0085 0.7756
Brugia malayi Protein kinase domain containing protein 0.0056 0.0045 0.0045
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0056 0.0045 0.0045
Schistosoma mansoni protein kinase 0.0056 0.0045 0.0045
Schistosoma mansoni protein kinase 0.007 0.0085 0.0085
Loa Loa (eye worm) hypothetical protein 0.0369 0.092 0.092
Schistosoma mansoni hypothetical protein 0.0054 0.0039 0.0039
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0056 0.0045 0.0036
Echinococcus granulosus insulin receptor 0.0056 0.0045 0.0052
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0045 0.0036
Echinococcus granulosus axis inhibition protein axin 0.0587 0.1528 0.1827
Echinococcus granulosus oxysterol binding protein 3 0.0054 0.0039 0.0046
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0045 0.0036
Brugia malayi Variant SH3 domain containing protein 0.0054 0.0039 0.0039
Loa Loa (eye worm) TK/ALK protein kinase 0.0293 0.0708 0.0708
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0056 0.0045 0.0052
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0056 0.0045 0.0045
Echinococcus multilocularis exocyst complex component 2 0.0162 0.0341 0.0406
Entamoeba histolytica tyrosin kinase, putative 0.0056 0.0045 0.0036
Brugia malayi ephrin receptor 1 precursor 0.0056 0.0045 0.0045
Schistosoma mansoni ephrin receptor 0.0061 0.0058 0.0058
Brugia malayi plexin A 0.1032 0.2771 0.2771
Loa Loa (eye worm) hypothetical protein 0.0054 0.0039 0.0039
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.0054 0.0039 0.0039
Schistosoma mansoni protein kinase 0.007 0.0085 0.0085
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0068 0.008 0.6862
Entamoeba histolytica protein kinase domain containing protein 0.0075 0.0099 0.04
Entamoeba histolytica protein kinase domain containing protein 0.0056 0.0045 0.0036
Echinococcus multilocularis heat shock protein 70 0.0056 0.0045 0.0052
Echinococcus multilocularis regulator of G protein signaling 7 0.0587 0.1528 0.1827
Echinococcus granulosus tyrosine protein kinase 0.0056 0.0045 0.0052
Entamoeba histolytica hypothetical protein 0.0587 0.1528 1
Entamoeba histolytica tyrosine kinase, putative 0.0056 0.0045 0.0036
Echinococcus multilocularis basement membrane specific heparan sulfate 0.011 0.0197 0.0234
Brugia malayi Protein kinase domain containing protein 0.0056 0.0045 0.0045
Schistosoma mansoni serine/threonine protein kinase 0.0056 0.0045 0.0045
Schistosoma mansoni protein tyrosine kinase 0.0056 0.0045 0.0045
Brugia malayi Calcitonin receptor-like protein seb-1 0.0058 0.0051 0.0051
Echinococcus granulosus exocyst complex component 2 0.0162 0.0341 0.0406
Onchocerca volvulus 0.0369 0.092 0.3864
Trypanosoma brucei Serine/threonine-protein kinase NEK21, putative 0.0068 0.008 0.6862
Brugia malayi TBC domain containing protein 0.0054 0.0039 0.0039
Brugia malayi PH domain containing protein 0.0054 0.0039 0.0039
Schistosoma mansoni tyrosine kinase 0.0056 0.0045 0.0045
Echinococcus multilocularis beta 1 syntrophin 0.0054 0.0039 0.0046
Echinococcus granulosus Regulator of G protein signaling 20 0.0587 0.1528 0.1827
Schistosoma mansoni serine/threonine protein kinase 0.2774 0.7639 0.7639
Schistosoma mansoni protein kinase 0.0056 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0056 0.0045 0.0045
Onchocerca volvulus 0.0056 0.0045 0.0023
Loa Loa (eye worm) TK protein kinase 0.0056 0.0045 0.0045
Leishmania major protein kinase, putative 0.0068 0.008 0.6862
Trichomonas vaginalis AGC family protein kinase 0.0068 0.008 0.0274
Entamoeba histolytica protein kinase domain containing protein 0.0056 0.0045 0.0036
Trichomonas vaginalis ribosomal protein S6 kinase, 90kD, polypeptide, putative 0.0068 0.008 0.0274
Echinococcus granulosus tyrosine protein kinase Src64B 0.0056 0.0045 0.0052
Schistosoma mansoni plexin 0.087 0.2319 0.2319
Loa Loa (eye worm) TK/FER protein kinase 0.0056 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0054 0.0039 0.0039
Loa Loa (eye worm) PXA domain-containing protein 0.0587 0.1528 0.1528
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0056 0.0045 0.0052
Brugia malayi Immunoglobulin I-set domain containing protein 0.0115 0.021 0.021
Echinococcus multilocularis epidermal growth factor receptor 0.0056 0.0045 0.0052
Brugia malayi Tyrosine-protein kinase PR2 0.0056 0.0045 0.0045
Trichomonas vaginalis AGC family protein kinase 0.0075 0.0099 0.04
Schistosoma mansoni tyrosine kinase 0.0056 0.0045 0.0045
Loa Loa (eye worm) TK protein kinase 0.0056 0.0045 0.0045
Entamoeba histolytica serine/threonine kinase, putative 0.0056 0.0045 0.0036
Loa Loa (eye worm) hypothetical protein 0.0369 0.092 0.092
Loa Loa (eye worm) TK/FER protein kinase 0.0056 0.0045 0.0045
Entamoeba histolytica protein kinase domain containing protein 0.0056 0.0045 0.0036
Entamoeba histolytica tyrosin kinase, putative 0.0056 0.0045 0.0036
Trichomonas vaginalis conserved hypothetical protein 0.0587 0.1528 1
Echinococcus granulosus GRB2 associated binding protein 3 0.0054 0.0039 0.0046
Echinococcus granulosus axis inhibition protein axin 0.0587 0.1528 0.1827
Entamoeba histolytica tyrosine kinase, putative 0.0056 0.0045 0.0036
Entamoeba histolytica protein kinase, putative 0.0068 0.008 0.0274
Echinococcus granulosus Pleckstrin y 0.0054 0.0039 0.0046
Schistosoma mansoni development and differentiation-enhancing factor ddef 0.0054 0.0039 0.0039
Entamoeba histolytica tyrosine kinase, putative 0.0056 0.0045 0.0036
Brugia malayi regulator of G-protein signaling egl-10 0.0587 0.1528 0.1528
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0056 0.0045 0.0052
Brugia malayi Protein kinase domain containing protein 0.0056 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0056 0.0045 0.0045
Brugia malayi GTP-ase activating protein for Arf containing protein 0.0054 0.0039 0.0039
Plasmodium falciparum protein kinase, putative 0.0056 0.0045 0.0894
Entamoeba histolytica tyrosine kinase, putative 0.0056 0.0045 0.0036
Entamoeba histolytica protein kinase, putative 0.0056 0.0045 0.0036
Brugia malayi PH domain containing protein 0.0054 0.0039 0.0039
Trypanosoma brucei Flagellum attachment zone protein 20 0.0056 0.0045 0.0894
Schistosoma mansoni hypothetical protein 0.0162 0.0341 0.0341
Echinococcus granulosus tyrosine protein kinase Lyn 0.007 0.0085 0.0101
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0075 0.0099 1
Entamoeba histolytica hypothetical protein 0.0587 0.1528 1
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.0068 0.008 0.6862
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0045 0.0036
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0045 0.0036
Loa Loa (eye worm) hypothetical protein 0.0056 0.0045 0.0045
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0045 0.0036
Onchocerca volvulus 0.0056 0.0045 0.0023
Brugia malayi hypothetical protein 0.0056 0.0045 0.0045
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0045 0.0036
Schistosoma mansoni oxysterol-binding protein 1 0.0054 0.0039 0.0039
Schistosoma mansoni protein kinase 0.0075 0.0099 0.0099
Loa Loa (eye worm) PH domain-containing protein 0.0054 0.0039 0.0039
Brugia malayi PH domain containing protein 0.0054 0.0039 0.0039
Echinococcus granulosus transcription factor collier 0.0162 0.0341 0.0406
Echinococcus granulosus tyrosine protein kinase csk 0.0056 0.0045 0.0052
Brugia malayi probable spectrin beta chain 0.0054 0.0039 0.0039
Echinococcus multilocularis neuroglian 0.011 0.0197 0.0234
Echinococcus multilocularis Ras associated and pleckstrin y 0.0054 0.0039 0.0046
Echinococcus multilocularis collagen type iv alpha 3 binding protein 0.0054 0.0039 0.0046
Loa Loa (eye worm) TK/FER protein kinase 0.0056 0.0045 0.0045
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0056 0.0045 0.0036
Echinococcus granulosus ras specific guanine nucleotide releasing factor 0.0054 0.0039 0.0046
Onchocerca volvulus 0.0056 0.0045 0.0023
Leishmania major protein kinase, putative 0.0075 0.0099 1
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0056 0.0045 0.0052
Loa Loa (eye worm) oxysterol binding protein 0.0054 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0587 0.1528 0.1528
Entamoeba histolytica hypothetical protein 0.0162 0.0341 0.2024
Echinococcus granulosus arf GAP with SH3 domain ANK repeat and PH 0.0054 0.0039 0.0046
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0587 0.1528 0.1528
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0056 0.0045 0.0052
Echinococcus multilocularis Rho GTPase activating protein 24 0.0054 0.0039 0.0046
Loa Loa (eye worm) TK/INSR protein kinase 0.0056 0.0045 0.0045
Schistosoma mansoni syntrophin 0.0054 0.0039 0.0039
Trichomonas vaginalis AGC family protein kinase 0.0068 0.008 0.0274
Plasmodium falciparum tyrosine kinase-like protein 0.0056 0.0045 0.0894
Echinococcus granulosus oxysterol binding protein 1 0.0054 0.0039 0.0046
Loa Loa (eye worm) hypothetical protein 0.0054 0.0039 0.0039
Brugia malayi Protein kinase domain containing protein 0.0056 0.0045 0.0045
Echinococcus granulosus epidermal growth factor receptor 0.0056 0.0045 0.0052
Loa Loa (eye worm) TK/FER protein kinase 0.0056 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0054 0.0039 0.0039
Brugia malayi Sema domain containing protein 0.0369 0.092 0.092
Trichomonas vaginalis AGC family protein kinase 0.0068 0.008 0.0274
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0056 0.0045 0.0052
Schistosoma mansoni vesicular amine transporter 0.0113 0.0204 0.0204
Entamoeba histolytica hypothetical protein 0.0056 0.0045 0.0036
Loa Loa (eye worm) protein kinase domain-containing protein 0.0056 0.0045 0.0045
Echinococcus multilocularis FL cytokine receptor 0.0056 0.0045 0.0052
Echinococcus granulosus defective proboscis extension response 0.011 0.0197 0.0234
Trypanosoma cruzi serine/threonine-protein kinase NRKB, putative 0.0068 0.008 0.6862
Loa Loa (eye worm) hypothetical protein 0.0587 0.1528 0.1528
Schistosoma mansoni tyrosine kinase 0.0056 0.0045 0.0045
Onchocerca volvulus 0.0056 0.0045 0.0023
Echinococcus multilocularis tyrosine protein kinase 0.0056 0.0045 0.0052
Entamoeba histolytica ankyrin repeat protein 0.0056 0.0045 0.0036
Entamoeba histolytica protein kinase , putative 0.0075 0.0099 0.04
Loa Loa (eye worm) TK protein kinase 0.0056 0.0045 0.0045
Echinococcus multilocularis Regulator of G protein signaling 20 0.0587 0.1528 0.1827
Brugia malayi Tyrosine-protein kinase abl-1 0.0056 0.0045 0.0045
Loa Loa (eye worm) sema domain-containing protein 0.0369 0.092 0.092
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0045 0.0036
Brugia malayi Cadps2 protein 0.0054 0.0039 0.0039
Trichomonas vaginalis serine/threonine-protein kinase wnk, putative 0.0056 0.0045 0.0036
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0045 0.0036
Brugia malayi Protein kinase domain containing protein 0.0056 0.0045 0.0045
Loa Loa (eye worm) TK/FER protein kinase 0.0056 0.0045 0.0045
Trichomonas vaginalis conserved hypothetical protein 0.0162 0.0341 0.2024
Trichomonas vaginalis AGC family protein kinase 0.0068 0.008 0.0274
Trichomonas vaginalis br serine/threonine-protein kinase, putative 0.0056 0.0045 0.0036
Entamoeba histolytica cysteine surface protein, putative 0.0056 0.0045 0.0036
Echinococcus multilocularis Pleckstrin y 0.0054 0.0039 0.0046
Entamoeba histolytica hypothetical protein 0.0056 0.0045 0.0036
Brugia malayi GTPase-activator protein for Ras-like GTPase containing protein 0.0054 0.0039 0.0039
Schistosoma mansoni tyrosine kinase 0.0056 0.0045 0.0045
Echinococcus multilocularis G protein coupled receptor kinase 6 0.3033 0.8361 1
Schistosoma mansoni serine/threonine protein kinase 0.0056 0.0045 0.0045
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0587 0.1528 0.1827
Brugia malayi Protein kinase domain containing protein 0.0056 0.0045 0.0045
Trichomonas vaginalis AGC family protein kinase 0.0068 0.008 0.0274
Loa Loa (eye worm) hypothetical protein 0.0162 0.0341 0.0341
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0075 0.0099 0.04
Onchocerca volvulus 0.087 0.2319 1
Entamoeba histolytica protein kinase domain containing protein 0.0056 0.0045 0.0036
Loa Loa (eye worm) TK/EPH protein kinase 0.0056 0.0045 0.0045
Loa Loa (eye worm) rho-GTPase-activating 0.0054 0.0039 0.0039
Echinococcus granulosus raf serine:threonine protein kinase 0.0056 0.0045 0.0052
Loa Loa (eye worm) plexin A 0.1032 0.2771 0.2771
Brugia malayi DNA-binding protein LAG-1 0.0162 0.0341 0.0341
Echinococcus granulosus dual specificity testis-specific protein kinase 0.007 0.0085 0.0101
Loa Loa (eye worm) hypothetical protein 0.0054 0.0039 0.0039
Echinococcus granulosus regulator of G protein signaling 7 0.0587 0.1528 0.1827
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.007 0.0085 0.7756
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0056 0.0045 0.0045
Brugia malayi hypothetical protein 0.0056 0.0045 0.0045
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0054 0.0039 0.0039
Entamoeba histolytica protein kinase domain containing protein 0.0056 0.0045 0.0036
Schistosoma mansoni tyrosine kinase 0.0056 0.0045 0.0045
Trichomonas vaginalis TK family protein kinase 0.0056 0.0045 0.0036
Plasmodium vivax tyrosine kinase-like protein, putative 0.0056 0.0045 0.0894
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0056 0.0045 0.0052
Brugia malayi Pleckstrin Homology Domain 0.0054 0.0039 0.0039
Brugia malayi Fibronectin type III domain containing protein 0.0115 0.021 0.021
Schistosoma mansoni hypothetical protein 0.0369 0.092 0.092
Echinococcus multilocularis Pleckstrin y 0.0054 0.0039 0.0046
Entamoeba histolytica protein kinase, putative 0.0056 0.0045 0.0036
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0056 0.0045 0.0045
Echinococcus multilocularis ephrin type A receptor 4 A 0.0056 0.0045 0.0052
Echinococcus multilocularis oxysterol binding protein 3 0.0054 0.0039 0.0046
Schistosoma mansoni protein kinase 0.007 0.0085 0.0085
Loa Loa (eye worm) TK/RYK protein kinase 0.0056 0.0045 0.0045
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0045 0.0036
Echinococcus granulosus regulator of G protein signaling 3 0.0587 0.1528 0.1827
Echinococcus granulosus c src tyrosine kinase 0.0056 0.0045 0.0052
Echinococcus granulosus protein tyrosine kinase 0.0056 0.0045 0.0052
Schistosoma mansoni regulator of G protein signaling 0.0587 0.1528 0.1528
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0045 0.0036
Loa Loa (eye worm) RGC/RGC protein kinase 0.0056 0.0045 0.0045
Trichomonas vaginalis 3-phosphoinositide dependent protein kinase-1, putative 0.0068 0.008 0.0274
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0056 0.0045 0.0045
Brugia malayi hypothetical protein 0.0115 0.021 0.021
Brugia malayi Protein kinase domain containing protein 0.0056 0.0045 0.0045
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0045 0.0036
Echinococcus multilocularis rac serine:threonine kinase 0.0068 0.008 0.0094
Brugia malayi PH domain containing protein 0.0054 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0056 0.0045 0.0045
Loa Loa (eye worm) TK/FER protein kinase 0.0056 0.0045 0.0045
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0045 0.0036
Echinococcus multilocularis tyrosine protein kinase csk 0.0056 0.0045 0.0052
Schistosoma mansoni tyrosine kinase 0.0056 0.0045 0.0045
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0045 0.0036
Plasmodium falciparum serine/threonine protein kinase, putative 0.0075 0.0099 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0056 0.0045 0.0036
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0045 0.0036
Echinococcus granulosus G protein coupled receptor kinase 1 0.2188 0.6 0.7176
Entamoeba histolytica receptor protein kinase, putative 0.0056 0.0045 0.0036
Entamoeba histolytica tyrosine kinase, putative 0.0056 0.0045 0.0036
Entamoeba histolytica hypothetical protein 0.0587 0.1528 1
Entamoeba histolytica tyrosine- protein kinase 2, putative 0.0056 0.0045 0.0036
Schistosoma mansoni hypothetical protein 0.0162 0.0341 0.0341
Schistosoma mansoni hypothetical protein 0.0054 0.0039 0.0039
Trypanosoma brucei NEK family Serine/threonine-protein kinase, putative 0.0068 0.008 0.6862
Entamoeba histolytica ankyrin repeat protein 0.0056 0.0045 0.0036
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0162 0.0341 0.2024
Entamoeba histolytica tyrosine kinase, putative 0.0056 0.0045 0.0036
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0056 0.0045 0.0036
Schistosoma mansoni voltage-gated potassium channel 0.0044 0.0012 0.0012
Brugia malayi Protein kinase domain containing protein 0.0056 0.0045 0.0045
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0045 0.0036
Entamoeba histolytica protein kinase, putative 0.0075 0.0099 0.04
Loa Loa (eye worm) TK/FAK protein kinase 0.0056 0.0045 0.0045
Echinococcus granulosus Pleckstrin domain containing protein family B 0.0054 0.0039 0.0046
Loa Loa (eye worm) AUR protein kinase 0.0075 0.0099 0.0099
Brugia malayi Protein kinase domain containing protein 0.0056 0.0045 0.0045
Brugia malayi PH domain containing protein 0.0054 0.0039 0.0039
Echinococcus granulosus collagen type iv alpha 3 binding protein 0.0054 0.0039 0.0046
Loa Loa (eye worm) TK/FER protein kinase 0.0056 0.0045 0.0045
Echinococcus multilocularis DCC interacting protein 13 beta 0.0054 0.0039 0.0046
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0056 0.0045 0.0052
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0587 0.1528 1
Loa Loa (eye worm) TK/FER protein kinase 0.0056 0.0045 0.0045
Brugia malayi SH2 domain containing protein 0.0056 0.0045 0.0045
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0075 0.0099 0.0117
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0061 0.0058 0.0068
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0045 0.0036
Entamoeba histolytica leucine-rich repeat domain-containing protein 0.0056 0.0045 0.0036
Entamoeba histolytica tyrosin kinase, putative 0.0217 0.0496 0.307
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0045 0.0036
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0162 0.0341 0.2024
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0056 0.0045 0.0045
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0587 0.1528 0.1827
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0061 0.0058 0.0068
Brugia malayi Dynamin 0.0054 0.0039 0.0039
Schistosoma mansoni tyrosine kinase 0.0056 0.0045 0.0045
Trichomonas vaginalis AGC family protein kinase 0.0068 0.008 0.0274
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0045 0.0036
Echinococcus multilocularis aurora kinase A 0.0075 0.0099 0.0117
Brugia malayi Protein kinase domain containing protein 0.0056 0.0045 0.0045
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.3033 0.8361 0.8361
Entamoeba histolytica protein kinase, putative 0.0056 0.0045 0.0036
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0045 0.0036
Entamoeba histolytica hypothetical protein 0.0056 0.0045 0.0036
Echinococcus multilocularis tyrosine protein kinase HCK 0.0056 0.0045 0.0052
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0045 0.0036
Schistosoma mansoni rhogef and pleckstrin domain protein 0.0054 0.0039 0.0039
Plasmodium falciparum tyrosine kinase-like protein 0.0056 0.0045 0.0894
Loa Loa (eye worm) RGC/RGC protein kinase 0.0056 0.0045 0.0045
Brugia malayi hypothetical protein 0.0369 0.092 0.092
Loa Loa (eye worm) hypothetical protein 0.0056 0.0045 0.0045
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0045 0.0036
Entamoeba histolytica protein kinase, putative 0.0068 0.008 0.0274
Echinococcus multilocularis tyrosine protein kinase Blk 0.0056 0.0045 0.0052
Entamoeba histolytica protein kinase, putative 0.0056 0.0045 0.0036
Onchocerca volvulus 0.0056 0.0045 0.0023
Brugia malayi PH domain containing protein 0.0054 0.0039 0.0039
Echinococcus multilocularis protein KINase family member (kin 25) 0.0056 0.0045 0.0052
Echinococcus multilocularis G protein coupled receptor kinase 1 0.2188 0.6 0.7176
Brugia malayi PXA domain containing protein 0.0587 0.1528 0.1528
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0056 0.0045 0.0052
Entamoeba histolytica protein kinase domain containing protein 0.0217 0.0496 0.307
Loa Loa (eye worm) hypothetical protein 0.0056 0.0045 0.0045
Echinococcus multilocularis type II inositol 3,4 bisphosphate 4 phosphatase 0.0054 0.0039 0.0046
Echinococcus multilocularis Pleckstrin domain containing protein, family B 0.0054 0.0039 0.0046
Schistosoma mansoni tyrosine protein kinase 0.0056 0.0045 0.0045
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0068 0.008 0.6862
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0045 0.0036
Entamoeba histolytica tyrosine kinase, putative 0.0056 0.0045 0.0036
Loa Loa (eye worm) TK/FER protein kinase 0.0056 0.0045 0.0045
Echinococcus multilocularis dual specificity testis specific protein kinase 0.007 0.0085 0.0101
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.0056 0.0045 0.0045
Entamoeba histolytica protein kinase domain containing protein 0.0056 0.0045 0.0036
Trichomonas vaginalis conserved hypothetical protein 0.0162 0.0341 0.2024
Trichomonas vaginalis conserved hypothetical protein 0.0162 0.0341 0.2024
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.004 0.0001 0.0001
Entamoeba histolytica PH domain containing protein kinase, putative 0.0068 0.008 0.0274
Plasmodium vivax protein kinase, putative 0.0056 0.0045 0.0894
Entamoeba histolytica PH domain containing protein kinase, putative 0.0068 0.008 0.0274
Trichomonas vaginalis AGC family protein kinase 0.0068 0.008 0.0274
Echinococcus granulosus tyrosine protein kinase Srms 0.0056 0.0045 0.0052
Echinococcus granulosus type II inositol 34 bisphosphate 4 phosphatase 0.0054 0.0039 0.0046
Echinococcus granulosus semaphorin 1A 0.0369 0.092 0.1099
Loa Loa (eye worm) hypothetical protein 0.011 0.0197 0.0197
Trichomonas vaginalis conserved hypothetical protein 0.0587 0.1528 1
Brugia malayi Sema domain containing protein 0.0369 0.092 0.092
Entamoeba histolytica tyrosine kinase, putative 0.0056 0.0045 0.0036
Trichomonas vaginalis conserved hypothetical protein 0.0587 0.1528 1
Schistosoma mansoni regulator of G protein signaling 0.0587 0.1528 0.1528
Brugia malayi Protein kinase domain containing protein 0.0056 0.0045 0.0045
Brugia malayi Protein kinase domain containing protein 0.0056 0.0045 0.0045
Echinococcus granulosus semaphorin 5B 0.0369 0.092 0.1099
Echinococcus multilocularis actin binding protein anillin 0.0054 0.0039 0.0046
Trichomonas vaginalis AGC family protein kinase 0.0068 0.008 0.0274
Loa Loa (eye worm) hypothetical protein 0.0587 0.1528 0.1528
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0075 0.0099 0.04
Entamoeba histolytica tyrosin kinase, putative 0.0056 0.0045 0.0036
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0056 0.0045 0.0036
Entamoeba histolytica hypothetical protein 0.0056 0.0045 0.0036
Schistosoma mansoni tyrosine kinase 0.0056 0.0045 0.0045
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0045 0.0036
Trypanosoma brucei protein kinase, putative 0.007 0.0085 0.7756
Schistosoma mansoni tyrosine kinase 0.0056 0.0045 0.0045
Trypanosoma cruzi Protein kinase B 0.0068 0.008 0.6862
Leishmania major protein kinase, putative,serine/threonine protein kinase, putative 0.0068 0.008 0.6862
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.004 0.0001 0.0001
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0045 0.0036
Toxoplasma gondii calcium dependent protein kinase CDPK7 0.0068 0.008 0.6862
Loa Loa (eye worm) TK protein kinase 0.0056 0.0045 0.0045
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0587 0.1528 0.1528
Echinococcus multilocularis tyrosine protein kinase shark 0.0056 0.0045 0.0052
Echinococcus granulosus myotubularin protein 13 0.0054 0.0039 0.0046
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0056 0.0045 0.0036
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0056 0.0045 0.0052
Trichomonas vaginalis conserved hypothetical protein 0.0162 0.0341 0.2024
Entamoeba histolytica protein kinase with ankyrin repeats, putative 0.0056 0.0045 0.0036
Schistosoma mansoni tyrosine kinase 0.0056 0.0045 0.0045
Echinococcus granulosus integrin linked protein kinase 0.0056 0.0045 0.0052
Echinococcus multilocularis arf GAP with coiled coil, ANK repeat and PH 0.0054 0.0039 0.0046
Entamoeba histolytica protein kinase, putative 0.0056 0.0045 0.0036
Echinococcus multilocularis oxysterol binding protein 9 0.0054 0.0039 0.0046
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0068 0.008 0.6862
Loa Loa (eye worm) hypothetical protein 0.0587 0.1528 0.1528
Brugia malayi Oxysterol-binding protein 0.0054 0.0039 0.0039
Brugia malayi Syntrophin-1 0.0054 0.0039 0.0039
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0045 0.0036
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0045 0.0036
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0056 0.0045 0.0045
Entamoeba histolytica tyrosine kinase, putative 0.0056 0.0045 0.0036
Entamoeba histolytica protein kinase domain containing protein 0.0056 0.0045 0.0036
Toxoplasma gondii protein kinase domain-containing protein 0.0056 0.0045 0.0894
Trichomonas vaginalis conserved hypothetical protein 0.0162 0.0341 0.2024
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0056 0.0045 0.0052
Entamoeba histolytica hypothetical protein 0.0162 0.0341 0.2024
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0056 0.0045 0.0052
Loa Loa (eye worm) hypothetical protein 0.087 0.2319 0.2319
Brugia malayi Protein kinase domain containing protein 0.0056 0.0045 0.0045
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.0056 0.0045 0.0045
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0045 0.0036
Echinococcus multilocularis pdz domain containing protein 0.0054 0.0039 0.0046
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0162 0.0341 0.2024
Entamoeba histolytica protein kinase, putative 0.0056 0.0045 0.0036
Trichomonas vaginalis AGC family protein kinase 0.0068 0.008 0.0274
Brugia malayi Protein kinase domain containing protein 0.0056 0.0045 0.0045
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0056 0.0045 0.0052
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0045 0.0036
Leishmania major serine/threonine-protein kinase a, putative 0.0068 0.008 0.6862
Schistosoma mansoni vav2 0.0054 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0115 0.021 0.021
Schistosoma mansoni serine/threonine-protein kinase 0.0068 0.008 0.008
Brugia malayi Protein kinase domain containing protein 0.0056 0.0045 0.0045
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0056 0.0045 0.0045
Echinococcus granulosus cytohesin 1 0.0054 0.0039 0.0046
Echinococcus granulosus Immunoglobulin 0.011 0.0197 0.0234
Loa Loa (eye worm) TK protein kinase 0.0056 0.0045 0.0045
Brugia malayi Protein kinase domain containing protein 0.0056 0.0045 0.0045
Echinococcus granulosus tyrosine kinase 0.0056 0.0045 0.0052
Schistosoma mansoni centaurin alpha 0.0054 0.0039 0.0039
Schistosoma mansoni goodpasture antigen-binding protein 0.0054 0.0039 0.0039
Schistosoma mansoni tyrosine kinase 0.0056 0.0045 0.0045
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0068 0.008 0.6862
Echinococcus granulosus dynamin 1 0.0054 0.0039 0.0046
Schistosoma mansoni serine/threonine protein kinase 0.3619 1 1
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0056 0.0045 0.0052
Trichomonas vaginalis AGC family protein kinase 0.0056 0.0045 0.0036
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.3619 1 1
Entamoeba histolytica protein kinase, putative 0.0068 0.008 0.0274
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0056 0.0045 0.0052
Entamoeba histolytica hypothetical protein 0.0056 0.0045 0.0036
Brugia malayi A-kinase anchor protein 10, precursor 0.0587 0.1528 0.1528
Loa Loa (eye worm) TK/DDR protein kinase 0.0056 0.0045 0.0045
Trichomonas vaginalis AGC family protein kinase 0.0068 0.008 0.0274
Trichomonas vaginalis AGC family protein kinase 0.0068 0.008 0.0274
Schistosoma mansoni myotubularin-related protein 0.0054 0.0039 0.0039
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0045 0.0036
Schistosoma mansoni serine/threonine RGC 0.0056 0.0045 0.0045
Echinococcus granulosus activated cdc42 kinase 1 0.0056 0.0045 0.0052
Echinococcus granulosus retinal guanylyl cyclase 2 0.0056 0.0045 0.0052
Loa Loa (eye worm) RGC/RGC protein kinase 0.0056 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0054 0.0039 0.0039
Echinococcus granulosus Pleckstrin y 0.0054 0.0039 0.0046
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0045 0.0036
Entamoeba histolytica protein kinase, putative 0.0056 0.0045 0.0036
Plasmodium falciparum protein kinase, putative 0.0056 0.0045 0.0894
Brugia malayi Immunoglobulin I-set domain containing protein 0.0166 0.0352 0.0352
Plasmodium falciparum calcium-dependent protein kinase 7 0.0068 0.008 0.6862
Entamoeba histolytica PH domain containing protein kinase, putative 0.0068 0.008 0.0274
Schistosoma mansoni tyrosine kinase 0.0056 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0115 0.021 0.021
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0045 0.0036
Brugia malayi Oxysterol binding protein 0.0054 0.0039 0.0039
Trichomonas vaginalis AGC family protein kinase 0.0068 0.008 0.0274
Schistosoma mansoni growth factor receptor-bound protein 0.0054 0.0039 0.0039
Trichomonas vaginalis AGC family protein kinase 0.0075 0.0099 0.04
Schistosoma mansoni hypothetical protein 0.0198 0.0441 0.0441
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0045 0.0036
Echinococcus multilocularis dynamin 1 0.0054 0.0039 0.0046
Loa Loa (eye worm) hypothetical protein 0.0209 0.0473 0.0473
Echinococcus granulosus pdz domain containing protein 0.0054 0.0039 0.0046
Trypanosoma brucei serine/threonine-protein kinase NRKB, putative 0.0068 0.008 0.6862
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0045 0.0036
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0056 0.0045 0.0045
Entamoeba histolytica protein kinase domain containing protein 0.007 0.0085 0.031
Toxoplasma gondii protein kinase domain-containing protein 0.0068 0.008 0.6862
Echinococcus multilocularis protein kinase 0.0056 0.0045 0.0052
Trichomonas vaginalis AGC family protein kinase 0.0075 0.0099 0.04
Echinococcus granulosus serine/threonine protein kinase 0.0068 0.008 0.0094
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0056 0.0045 0.0036
Loa Loa (eye worm) hypothetical protein 0.0054 0.0039 0.0039
Echinococcus multilocularis Immunoglobulin 0.011 0.0197 0.0234
Brugia malayi Uncoordinated protein 104 0.0054 0.0039 0.0039
Schistosoma mansoni tyrosine kinase 0.0056 0.0045 0.0045
Brugia malayi Plexin repeat family protein 0.087 0.2319 0.2319
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.0054 0.0039 0.0039
Schistosoma mansoni rho gtpase activating protein 0.0054 0.0039 0.0039
Loa Loa (eye worm) TK/ROR protein kinase 0.0056 0.0045 0.0045
Entamoeba histolytica protein kinase, putative 0.0068 0.008 0.0274
Trypanosoma brucei Pseudokinase, putative 0.0056 0.0045 0.0894
Schistosoma mansoni nephrin 0.0115 0.021 0.021
Echinococcus multilocularis axis inhibition protein axin 0.0587 0.1528 0.1827
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0056 0.0045 0.0036
Schistosoma mansoni tyrosine kinase 0.0056 0.0045 0.0045
Loa Loa (eye worm) TK/FER protein kinase 0.0056 0.0045 0.0045
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0056 0.0045 0.0045
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0045 0.0036
Schistosoma mansoni tyrosine kinase 0.0056 0.0045 0.0045
Loa Loa (eye worm) serine/threonine protein kinase 0.0056 0.0045 0.0045
Schistosoma mansoni protein kinase 0.0056 0.0045 0.0045
Entamoeba histolytica PH domain containing protein kinase, putative 0.0068 0.008 0.0274
Onchocerca volvulus 0.0056 0.0045 0.0023
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.3033 0.8361 0.8361
Schistosoma mansoni regulator of G protein signaling 0.0587 0.1528 0.1528
Echinococcus multilocularis activated cdc42 kinase 1 0.0056 0.0045 0.0052
Brugia malayi protein-tyrosine kinase 0.0056 0.0045 0.0045
Trichomonas vaginalis serine-threonine protein kinase, putative 0.0056 0.0045 0.0036
Brugia malayi hypothetical protein 0.0056 0.0045 0.0045
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0045 0.0036
Trypanosoma cruzi NIMA-related kinase, putative 0.0068 0.008 0.6862
Trichomonas vaginalis AGC family protein kinase 0.0068 0.008 0.0274
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0056 0.0045 0.0052
Brugia malayi PXA domain containing protein 0.0587 0.1528 0.1528
Entamoeba histolytica protein kinase, putative 0.0056 0.0045 0.0036
Brugia malayi Protein kinase domain containing protein 0.0056 0.0045 0.0045
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0056 0.0045 0.0052
Entamoeba histolytica protein kinase domain containing protein 0.0056 0.0045 0.0036
Entamoeba histolytica hypothetical protein 0.0068 0.008 0.0274
Loa Loa (eye worm) hypothetical protein 0.0054 0.0039 0.0039
Loa Loa (eye worm) Plekhf2 protein 0.0054 0.0039 0.0039
Entamoeba histolytica protein kinase, putative 0.0056 0.0045 0.0036
Entamoeba histolytica tyrosine kinase, putative 0.0056 0.0045 0.0036
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0045 0.0036
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0056 0.0045 0.0052
Schistosoma mansoni regulator of G protein signaling 0.0587 0.1528 0.1528
Loa Loa (eye worm) hypothetical protein 0.0054 0.0039 0.0039
Brugia malayi Protein kinase domain containing protein 0.0056 0.0045 0.0045
Entamoeba histolytica protein kinase domain containing protein 0.0056 0.0045 0.0036
Echinococcus granulosus epidermal growth factor receptor 0.0056 0.0045 0.0052
Echinococcus multilocularis beta adrenergic receptor kinase 0.2774 0.7639 0.9137
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0056 0.0045 0.0045
Echinococcus multilocularis tyrosine protein kinase pr2 0.0056 0.0045 0.0052
Entamoeba histolytica tyrosine kinase, putative 0.0056 0.0045 0.0036
Schistosoma mansoni hypothetical protein 0.0056 0.0045 0.0045
Echinococcus multilocularis myotubularin protein 13 0.0054 0.0039 0.0046
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.011 0.0197 0.0234
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0045 0.0036
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0058 0.0051 0.0051
Brugia malayi Protein kinase domain containing protein 0.0056 0.0045 0.0045
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0045 0.0036
Entamoeba histolytica p21-activated kinase 0.0068 0.008 0.0274
Entamoeba histolytica protein kinase, putative 0.0075 0.0099 0.04
Trichomonas vaginalis AGC family protein kinase 0.0068 0.008 0.0274
Echinococcus granulosus tyrosine kinase 0.0056 0.0045 0.0052
Echinococcus granulosus neuroglian 0.011 0.0197 0.0234
Echinococcus granulosus aurora kinase A 0.0075 0.0099 0.0117
Trichomonas vaginalis STE family protein kinase 0.0056 0.0045 0.0036
Echinococcus granulosus Pleckstrin y 0.0054 0.0039 0.0046
Brugia malayi Protein kinase domain containing protein 0.0056 0.0045 0.0045
Schistosoma mansoni fibrocystin l 0.0162 0.0341 0.0341
Brugia malayi PH domain containing protein 0.0054 0.0039 0.0039
Entamoeba histolytica PH domain containing protein kinase, putative 0.0068 0.008 0.0274
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0045 0.0036
Trypanosoma cruzi protein kinase, putative 0.0056 0.0045 0.0894
Loa Loa (eye worm) hypothetical protein 0.0162 0.0341 0.0341
Echinococcus granulosus regulator of G protein signaling 7 0.0587 0.1528 0.1827
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0045 0.0036
Brugia malayi Protein kinase domain containing protein 0.0056 0.0045 0.0045
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0056 0.0045 0.0052
Entamoeba histolytica hypothetical protein 0.0162 0.0341 0.2024
Entamoeba histolytica protein kinase domain containing protein 0.0056 0.0045 0.0036
Loa Loa (eye worm) G protein-coupled receptor kinase 1 0.3033 0.8361 0.8361
Entamoeba histolytica protein kinase, putative 0.0068 0.008 0.0274
Onchocerca volvulus 0.0056 0.0045 0.0023
Entamoeba histolytica protein kinase domain containing protein 0.0056 0.0045 0.0036
Trichomonas vaginalis AGC family protein kinase 0.0068 0.008 0.0274
Echinococcus granulosus tyrosine protein kinase Fyn 0.0056 0.0045 0.0052
Schistosoma mansoni oxysterol-binding protein 1 0.0054 0.0039 0.0039
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0056 0.0045 0.0052
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0056 0.0045 0.0045
Entamoeba histolytica protein kinase domain containing protein 0.0056 0.0045 0.0036
Loa Loa (eye worm) hypothetical protein 0.011 0.0197 0.0197
Leishmania major protein kinase, putative 0.0068 0.008 0.6862
Entamoeba histolytica protein kinase, putative 0.0056 0.0045 0.0036
Entamoeba histolytica hypothetical protein 0.0056 0.0045 0.0036
Schistosoma mansoni tyrosine kinase 0.0056 0.0045 0.0045
Echinococcus multilocularis Oxysterol binding protein 11 0.0054 0.0039 0.0046
Loa Loa (eye worm) hypothetical protein 0.0054 0.0039 0.0039
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0045 0.0036
Brugia malayi Guanylyl cyclase protein 23 0.0056 0.0045 0.0045
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0056 0.0045 0.0036
Schistosoma mansoni protein kinase 0.0056 0.0045 0.0045
Toxoplasma gondii STE kinase 0.0056 0.0045 0.0894
Onchocerca volvulus 0.0056 0.0045 0.0023
Echinococcus multilocularis plexin a4 0.1032 0.2771 0.3313
Schistosoma mansoni ephrin receptor 0.0056 0.0045 0.0045
Schistosoma mansoni tyrosine kinase 0.0056 0.0045 0.0045
Schistosoma mansoni Neurotrimin precursor (hNT) 0.011 0.0197 0.0197
Schistosoma mansoni tyrosine kinase 0.0056 0.0045 0.0045
Schistosoma mansoni goodpasture antigen-binding protein 0.0054 0.0039 0.0039
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0075 0.0099 0.0117
Entamoeba histolytica tyrosine kinase, putative 0.0056 0.0045 0.0036
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0056 0.0045 0.0052
Trypanosoma brucei aurora B kinase 0.0075 0.0099 1
Trypanosoma cruzi protein kinase, putative 0.0056 0.0045 0.0894
Leishmania major protein kinase, putative 0.0056 0.0045 0.0894
Entamoeba histolytica protein kinase, putative 0.0056 0.0045 0.0036
Loa Loa (eye worm) TK/FER protein kinase 0.0056 0.0045 0.0045
Schistosoma mansoni protein kinase 0.0056 0.0045 0.0045
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0045 0.0036
Schistosoma mansoni hypothetical protein 0.0369 0.092 0.092
Entamoeba histolytica protein kinase domain containing protein 0.0056 0.0045 0.0036
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0045 0.0036
Loa Loa (eye worm) hypothetical protein 0.0056 0.0045 0.0045
Echinococcus granulosus calcium dependent secretion activator 1 0.0054 0.0039 0.0046
Echinococcus multilocularis tyrosine protein kinase Abl 0.0056 0.0045 0.0052
Echinococcus multilocularis tyrosine protein kinase csk 0.0056 0.0045 0.0052
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0058 0.0051 0.0051
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0045 0.0036
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0045 0.0036
Echinococcus granulosus tyrosine protein kinase Src42A 0.0056 0.0045 0.0052
Schistosoma mansoni tyrosine kinase 0.0056 0.0045 0.0045
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0045 0.0036
Onchocerca volvulus Tyrosine kinase homolog 0.0056 0.0045 0.0023
Loa Loa (eye worm) TK/FER protein kinase 0.0056 0.0045 0.0045
Schistosoma mansoni zinc finger protein 0.0054 0.0039 0.0039
Brugia malayi Furin-like cysteine rich region family protein 0.0056 0.0045 0.0045
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0045 0.0036
Entamoeba histolytica protein kinase domain containing protein 0.0056 0.0045 0.0036
Echinococcus granulosus protein kinase 0.0056 0.0045 0.0052
Trichomonas vaginalis AGC family protein kinase 0.0068 0.008 0.0274
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0045 0.0036
Echinococcus granulosus fibroblast growth factor receptor 4 0.0056 0.0045 0.0052
Trichomonas vaginalis AGC family protein kinase 0.0068 0.008 0.0274
Loa Loa (eye worm) hypothetical protein 0.0054 0.0039 0.0039
Echinococcus multilocularis tyrosine protein kinase Srms 0.0056 0.0045 0.0052
Echinococcus granulosus kinase suppressor of Ras 1 0.0056 0.0045 0.0052
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0045 0.0036
Entamoeba histolytica protein kinase domain containing protein 0.0056 0.0045 0.0036
Echinococcus granulosus geminin 0.0198 0.0441 0.0526
Brugia malayi Protein kinase domain containing protein 0.0056 0.0045 0.0045
Trypanosoma brucei rac serine-threonine kinase, putative 0.0068 0.008 0.6862
Echinococcus multilocularis natriuretic peptide receptor 1 0.0056 0.0045 0.0052
Echinococcus granulosus pleckstrin y domain containing family A 0.0054 0.0039 0.0046
Onchocerca volvulus 0.0056 0.0045 0.0023
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0056 0.0045 0.0052
Schistosoma mansoni src-type protein tyrosine kinase-related 0.0056 0.0045 0.0045
Echinococcus granulosus tyrosine protein kinase HCK 0.0056 0.0045 0.0052
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0045 0.0036
Entamoeba histolytica hypothetical protein 0.0056 0.0045 0.0036
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.011 0.0197 0.0197
Trypanosoma cruzi NIMA-related kinase, putative 0.0068 0.008 0.6862
Loa Loa (eye worm) hypothetical protein 0.0369 0.092 0.092
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0045 0.0036
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0056 0.0045 0.0052
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0045 0.0036
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0587 0.1528 0.1528
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0056 0.0045 0.0052
Echinococcus granulosus natriuretic peptide receptor 1 0.0056 0.0045 0.0052
Loa Loa (eye worm) AUR protein kinase 0.0075 0.0099 0.0099
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0045 0.0036
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0056 0.0045 0.0052
Echinococcus granulosus roundabout 2 0.0115 0.021 0.025
Loa Loa (eye worm) hypothetical protein 0.0162 0.0341 0.0341
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0056 0.0045 0.0894
Echinococcus multilocularis GRB2 associated binding protein 3 0.0054 0.0039 0.0046
Loa Loa (eye worm) TK/ABL protein kinase 0.0056 0.0045 0.0045
Brugia malayi MAX-1A 0.0054 0.0039 0.0039
Echinococcus granulosus [G-protein-coupledreceptor] kinase 0.3033 0.8361 1
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0056 0.0045 0.0052
Entamoeba histolytica protein kinase, putative 0.0056 0.0045 0.0036
Brugia malayi Dynamin 0.0054 0.0039 0.0039
Entamoeba histolytica tyrosine kinase, putative 0.0056 0.0045 0.0036
Entamoeba histolytica hypothetical protein, conserved 0.0056 0.0045 0.0036
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0587 0.1528 0.1528
Brugia malayi Regulator of G protein signaling domain containing protein 0.0587 0.1528 0.1528
Loa Loa (eye worm) hypothetical protein 0.0369 0.092 0.092
Entamoeba histolytica protein kinase, putative 0.0068 0.008 0.0274
Schistosoma mansoni tyrosine kinase 0.0056 0.0045 0.0045
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0056 0.0045 0.0052
Brugia malayi Protein kinase domain containing protein 0.0293 0.0708 0.0708
Brugia malayi SH2 domain containing protein 0.0056 0.0045 0.0045
Echinococcus granulosus retinal guanylyl cyclase 2 0.0056 0.0045 0.0052
Entamoeba histolytica protein kinase, putative 0.0056 0.0045 0.0036
Entamoeba histolytica protein kinase, putative 0.0056 0.0045 0.0036
Loa Loa (eye worm) hypothetical protein 0.0054 0.0039 0.0039
Loa Loa (eye worm) TK/FER protein kinase 0.0056 0.0045 0.0045
Loa Loa (eye worm) TK protein kinase 0.0056 0.0045 0.0045
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0056 0.0045 0.0045
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0056 0.0045 0.0052
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0056 0.0045 0.0894
Brugia malayi Protein kinase domain containing protein 0.0056 0.0045 0.0045
Trichomonas vaginalis AGC family protein kinase 0.0068 0.008 0.0274
Giardia lamblia Aurora kinase 0.0075 0.0099 1
Brugia malayi Protein kinase domain containing protein 0.0068 0.008 0.008
Brugia malayi Probable exocyst complex component Sec5 0.0162 0.0341 0.0341
Schistosoma mansoni tyrosine kinase 0.0056 0.0045 0.0045
Brugia malayi C-terminal src kinase protein 1 0.0056 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0056 0.0045 0.0045
Entamoeba histolytica serine/threonine kinase, putative 0.0056 0.0045 0.0036
Entamoeba histolytica cell surface protease gp63, putative 0.0162 0.0341 0.2024
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0056 0.0045 0.0052
Onchocerca volvulus 0.0056 0.0045 0.0023
Echinococcus multilocularis tyrosine kinase 0.0056 0.0045 0.0052
Schistosoma mansoni hypothetical protein 0.0054 0.0039 0.0039
Schistosoma mansoni serine/threonine protein kinase 0.0056 0.0045 0.0045
Echinococcus granulosus tyrosine protein kinase shark 0.0056 0.0045 0.0052
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0045 0.0036
Onchocerca volvulus 0.0056 0.0045 0.0023
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0045 0.0036
Echinococcus multilocularis arf GAP with SH3 domain, ANK repeat and PH 0.0054 0.0039 0.0046
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0056 0.0045 0.0052
Brugia malayi bone morphogenetic protein type 1 receptor 0.0056 0.0045 0.0045
Schistosoma mansoni tyrosine kinase 0.0056 0.0045 0.0045
Echinococcus granulosus regulator of G protein signaling 3 0.0587 0.1528 0.1827
Echinococcus granulosus Oxysterol binding protein 11 0.0054 0.0039 0.0046
Loa Loa (eye worm) RGC/RGC protein kinase 0.0056 0.0045 0.0045
Echinococcus granulosus beta-adrenergic receptor kinase 0.2774 0.7639 0.9137
Brugia malayi hypothetical protein 0.0369 0.092 0.092
Entamoeba histolytica PH domain containing protein kinase, putative 0.0068 0.008 0.0274
Trypanosoma cruzi serine/threonine protein kinase, putative 0.0068 0.008 0.6862
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0162 0.0341 0.2024
Schistosoma mansoni regulator of G protein signaling 0.0587 0.1528 0.1528
Echinococcus granulosus ephrin type A receptor 4 A 0.0056 0.0045 0.0052
Echinococcus multilocularis ras specific guanine nucleotide releasing factor 0.0054 0.0039 0.0046
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0056 0.0045 0.0045
Entamoeba histolytica hypothetical protein 0.0056 0.0045 0.0036
Echinococcus multilocularis geminin 0.0198 0.0441 0.0526
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0045 0.0036
Entamoeba histolytica tyrosine kinase, putative 0.0056 0.0045 0.0036
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0056 0.0045 0.0036
Loa Loa (eye worm) hypothetical protein 0.0054 0.0039 0.0039
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0045 0.0036
Loa Loa (eye worm) RGS-3 protein 0.0587 0.1528 0.1528
Echinococcus granulosus activin receptor type 0.007 0.0085 0.0101
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0056 0.0045 0.0052
Echinococcus multilocularis tyrosine protein kinase csk 0.0056 0.0045 0.0052
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0056 0.0045 0.0023
Echinococcus multilocularis Arf GAP and Pleckstrin domain containing protein 0.0054 0.0039 0.0046
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0045 0.0036
Entamoeba histolytica tyrosine kinase, putative 0.0056 0.0045 0.0036
Echinococcus granulosus tyrosine protein kinase Fyn 0.0056 0.0045 0.0052
Echinococcus multilocularis transcription factor collier 0.0162 0.0341 0.0406
Trichomonas vaginalis conserved hypothetical protein 0.0162 0.0341 0.2024
Entamoeba histolytica protein kinase, putative 0.0068 0.008 0.0274
Loa Loa (eye worm) TK protein kinase 0.0056 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0115 0.021 0.021
Loa Loa (eye worm) hypothetical protein 0.011 0.0197 0.0197
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0045 0.0036
Loa Loa (eye worm) hypothetical protein 0.011 0.0197 0.0197
Echinococcus multilocularis FERM and pleckstrin domain containing protein 0.0054 0.0039 0.0046
Schistosoma mansoni tyrosine kinase 0.0056 0.0045 0.0045
Trichomonas vaginalis protein kinase atn1, putative 0.0056 0.0045 0.0036
Entamoeba histolytica protein kinase domain containing protein 0.0056 0.0045 0.0036
Loa Loa (eye worm) TK/ACK protein kinase 0.0056 0.0045 0.0045
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0045 0.0036
Loa Loa (eye worm) hypothetical protein 0.0054 0.0039 0.0039
Echinococcus multilocularis insulin receptor 0.0056 0.0045 0.0052
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0075 0.0099 0.04
Schistosoma mansoni zinc finger protein 0.0054 0.0039 0.0039
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0056 0.0045 0.0052
Loa Loa (eye worm) AUR protein kinase 0.0075 0.0099 0.0099
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0068 0.008 0.6862
Brugia malayi integrin-linked kinase 0.0056 0.0045 0.0045
Entamoeba histolytica hypothetical protein 0.0056 0.0045 0.0036
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0068 0.008 0.6862
Trichomonas vaginalis AGC family protein kinase 0.0068 0.008 0.0274
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0045 0.0036
Echinococcus multilocularis raf serine:threonine protein kinase 0.0056 0.0045 0.0052
Entamoeba histolytica protein kinase, putative 0.0056 0.0045 0.0036
Toxoplasma gondii aurora kinase 0.0075 0.0099 1
Echinococcus granulosus tyrosine protein kinase csk 0.0056 0.0045 0.0052
Brugia malayi Protein kinase domain containing protein 0.0056 0.0045 0.0045
Trichomonas vaginalis AGC family protein kinase 0.0068 0.008 0.0274
Echinococcus multilocularis protein kinase 0.0056 0.0045 0.0052
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0045 0.0036
Schistosoma mansoni hypothetical protein 0.0198 0.0441 0.0441
Echinococcus multilocularis oxysterol binding protein 1 0.0054 0.0039 0.0046
Loa Loa (eye worm) hypothetical protein 0.0054 0.0039 0.0039
Schistosoma mansoni hypothetical protein 0.0054 0.0039 0.0039
Brugia malayi Protein kinase domain containing protein 0.0056 0.0045 0.0045
Schistosoma mansoni phosphoinositol 4-phosphate adaptor protein 0.0054 0.0039 0.0039
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0056 0.0045 0.0036
Schistosoma mansoni protein kinase 0.0056 0.0045 0.0045
Entamoeba histolytica serine/threonine kinase, putative 0.0056 0.0045 0.0036
Entamoeba histolytica protein kinase domain containing protein 0.0056 0.0045 0.0036
Entamoeba histolytica serine/threonine kinase, putative 0.0056 0.0045 0.0036
Brugia malayi PH domain containing protein 0.0054 0.0039 0.0039
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0068 0.008 0.6862
Brugia malayi SRC-1 0.0056 0.0045 0.0045
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0056 0.0045 0.0036
Trichomonas vaginalis AGC family protein kinase 0.0068 0.008 0.0274
Echinococcus multilocularis regulator of G protein signaling 3 0.0587 0.1528 0.1827
Loa Loa (eye worm) TK protein kinase 0.0056 0.0045 0.0045
Loa Loa (eye worm) AGC/AKT protein kinase 0.0068 0.008 0.008
Loa Loa (eye worm) TK/FER protein kinase 0.0056 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0056 0.0045 0.0045
Echinococcus granulosus arf GAP with coiled coil ANK repeat and PH 0.0054 0.0039 0.0046
Schistosoma mansoni protein kinase 0.0056 0.0045 0.0045
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0045 0.0036
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0056 0.0045 0.0052
Echinococcus multilocularis c src tyrosine kinase 0.0056 0.0045 0.0052
Loa Loa (eye worm) hypothetical protein 0.0054 0.0039 0.0039
Entamoeba histolytica tyrosine kinase, putative 0.0056 0.0045 0.0036
Schistosoma mansoni cell adhesion molecule 0.0115 0.021 0.021
Trypanosoma brucei AGC/RSK family serine/threonine kinase, putative 0.0056 0.0045 0.0894
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0045 0.0036
Loa Loa (eye worm) hypothetical protein 0.0054 0.0039 0.0039
Trichomonas vaginalis TKL family protein kinase 0.0056 0.0045 0.0036
Schistosoma mansoni serine/threonine protein kinase 0.0056 0.0045 0.0045
Echinococcus multilocularis tyrosine protein kinase csk 0.0056 0.0045 0.0052
Echinococcus multilocularis integrin linked protein kinase 0.0056 0.0045 0.0052
Schistosoma mansoni protein kinase 0.0056 0.0045 0.0045
Brugia malayi Raf kinase 0.0056 0.0045 0.0045
Echinococcus multilocularis regulator of G protein signaling 7 0.0587 0.1528 0.1827
Loa Loa (eye worm) hypothetical protein 0.0056 0.0045 0.0045
Entamoeba histolytica hypothetical protein 0.0056 0.0045 0.0036
Entamoeba histolytica protein kinase, putative 0.0056 0.0045 0.0036
Entamoeba histolytica tyrosine kinase, putative 0.0056 0.0045 0.0036
Loa Loa (eye worm) hypothetical protein 0.0054 0.0039 0.0039

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) > 100 um PUBCHEM_BIOASSAY: In Vitro Bfl-1 Dose Response Fluorescence Polarization Assay for SAR Study. (Class of assay: confirmatory) [Related pubchem assays: 621, 432 ] ChEMBL. No reference
IC50 (binding) > 100 um PUBCHEM_BIOASSAY: TR-FRET secondary assay for HTS discovery of chemical inhibitors of anti-apoptotic protein Bfl-1. (Class of assay: confirmatory) [Related pubchem assays: 432 ] ChEMBL. No reference
IC50 (binding) > 100 um PUBCHEM_BIOASSAY: GAPDH Dose Response Colorimetric Assay. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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