Detailed information for compound 1408426

Basic information

Technical information
  • TDR Targets ID: 1408426
  • Name: 1-[(1-acetyl-5-bromo-2,3-dihydroindol-7-yl)su lfonyl]-N-(2,3-dimethylphenyl)piperidine-4-ca rboxamide
  • MW: 534.466 | Formula: C24H28BrN3O4S
  • H donors: 1 H acceptors: 4 LogP: 3.21 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C(C1CCN(CC1)S(=O)(=O)c1cc(Br)cc2c1N(CC2)C(=O)C)Nc1cccc(c1C)C
  • InChi: 1S/C24H28BrN3O4S/c1-15-5-4-6-21(16(15)2)26-24(30)18-7-10-27(11-8-18)33(31,32)22-14-20(25)13-19-9-12-28(17(3)29)23(19)22/h4-6,13-14,18H,7-12H2,1-3H3,(H,26,30)
  • InChiKey: TZWQUVHMKXYPGQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(1-acetyl-5-bromo-indolin-7-yl)sulfonyl-N-(2,3-dimethylphenyl)piperidine-4-carboxamide
  • 1-[(1-acetyl-5-bromo-7-indolinyl)sulfonyl]-N-(2,3-dimethylphenyl)-4-piperidinecarboxamide
  • 1-(1-acetyl-5-bromo-indolin-7-yl)sulfonyl-N-(2,3-dimethylphenyl)isonipecotamide
  • 1-[(5-bromo-1-ethanoyl-2,3-dihydroindol-7-yl)sulfonyl]-N-(2,3-dimethylphenyl)piperidine-4-carboxamide
  • EU-0057657
  • C256-0065
  • NCGC00105930-01

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus fetal alzheimer antigen falz 0.002 0.0312 0.0379
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0013 0.014 0.0183
Onchocerca volvulus 0.0017 0.0243 0.0243
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0041 0.082 0.082
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0029 0.0521 0.0911
Trichomonas vaginalis taga, putative 0.002 0.0317 0.0317
Echinococcus granulosus calpain A 0.0029 0.0534 0.0649
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0029 0.0534 0.0649
Schistosoma mansoni ubiquitin conjugating enzyme 13 0.0279 0.6649 0.8079
Entamoeba histolytica deoxycytidine triphosphate deaminase, putative 0.0111 0.2527 0.3313
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0053 0.1109 0.1348
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0041 0.082 0.082
Schistosoma mansoni zinc finger protein 0.0013 0.0129 0.0157
Brugia malayi calpain family protein 1 0.0028 0.0503 0.0574
Brugia malayi Cathepsin L-like precursor 0.0041 0.082 0.0935
Leishmania major importin beta-1 subunit, putative 0.0016 0.0201 0.0302
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0053 0.1109 0.1348
Entamoeba histolytica ubiquitin-conjugating enzyme family protein 0.0279 0.6649 0.8718
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0013 0.014 0.017
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0013 0.014 0.021
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.002 0.0317 0.0317
Trypanosoma cruzi cysteine peptidase, putative 0.0113 0.2583 0.3885
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0044 0.0054
Echinococcus granulosus calpain 5 0.0011 0.0074 0.009
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0021 0.0332 0.0332
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0013 0.014 0.021
Entamoeba histolytica cysteine protease, putative 0.0021 0.0332 0.0436
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0047 0.097 0.1179
Plasmodium vivax multidrug resistance protein 1, putative 0.002 0.0317 0.0416
Echinococcus multilocularis cathepsin L cysteine protease 0.0041 0.082 0.0996
Echinococcus granulosus multidrug resistance protein 1 0.002 0.0317 0.0385
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.005 0.1049 0.1275
Schistosoma mansoni hypothetical protein 0.0343 0.8231 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0041 0.082 0.082
Echinococcus multilocularis peptidyl glycine alpha amidating monooxygenase 0.0191 0.4503 0.5471
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0034 0.0641 0.0591
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0102 0.2305 0.2629
Trypanosoma cruzi cysteine proteinase, putative 0.0021 0.0332 0.05
Echinococcus granulosus dnaJ subfamily B 0.0343 0.8231 1
Mycobacterium tuberculosis Probable esterase LipL 0.0029 0.0521 0.0911
Leishmania major ubiquitin-conjugating enzyme e2, putative 0.0279 0.6649 1
Echinococcus multilocularis calpain A 0.0029 0.0534 0.0649
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.002 0.0317 0.0317
Wolbachia endosymbiont of Brugia malayi deoxycytidine triphosphate deaminase 0.0111 0.2527 0.3132
Loa Loa (eye worm) hypothetical protein 0.0027 0.0487 0.0556
Trypanosoma cruzi cysteine peptidase, putative 0.0113 0.2583 0.3885
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0111 0.2539 0.3084
Loa Loa (eye worm) multidrug resistance protein 3 0.002 0.0317 0.0362
Entamoeba histolytica P-glycoprotein-1 0.002 0.0317 0.0416
Trypanosoma cruzi cysteine peptidase, putative 0.0014 0.0147 0.0221
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0113 0.2583 0.3885
Trypanosoma brucei PAB1-binding protein , putative 0.002 0.0309 0.0465
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.002 0.0317 0.0317
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0029 0.0521 0.1375
Schistosoma mansoni cathepsin s 0.0014 0.0147 0.0178
Entamoeba histolytica hypothetical protein 0.0319 0.7627 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0029 0.0521 0.0633
Echinococcus granulosus GTP binding nuclear protein Ran 0.0014 0.0165 0.02
Leishmania major cathepsin L-like protease 0.0041 0.082 0.1233
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0068 0.1472 0.2213
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0041 0.082 0.082
Onchocerca volvulus 0.0041 0.082 0.082
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0083 0.186 0.2122
Echinococcus granulosus cathepsin L cysteine proteinase 0.0041 0.082 0.0996
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.002 0.0317 0.0416
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.002 0.0317 0.0317
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0028 0.0503 0.0611
Loa Loa (eye worm) hypothetical protein 0.0034 0.0653 0.0745
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.002 0.0317 0.0317
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0279 0.6649 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0029 0.0521 0.0911
Loa Loa (eye worm) hypothetical protein 0.0014 0.0147 0.0167
Trypanosoma brucei importin beta-1 subunit, putative 0.0019 0.0291 0.0437
Brugia malayi beta-lactamase family protein 0.0029 0.0521 0.0595
Entamoeba histolytica cysteine protease, putative 0.0041 0.082 0.1075
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0029 0.0521 0.0595
Onchocerca volvulus 0.0029 0.0521 0.0521
Brugia malayi RNA, U transporter 1 0.0055 0.1169 0.1333
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0111 0.2539 0.3084
Schistosoma mansoni multidrug resistance protein 0.002 0.0317 0.0385
Leishmania major p-glycoprotein 0.002 0.0317 0.0477
Echinococcus granulosus geminin 0.0162 0.379 0.4604
Plasmodium falciparum cysteine proteinase falcipain 3 0.0041 0.082 0.1075
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0016 0.0201 0.0245
Brugia malayi Cathepsin L-like precursor 0.0041 0.082 0.0935
Trypanosoma cruzi PAB1-binding protein , putative 0.002 0.0309 0.0465
Leishmania major cathepsin L-like protease 0.0113 0.2583 0.3885
Echinococcus granulosus dUTP pyrophosphatase 0.0319 0.7627 0.9266
Loa Loa (eye worm) beta-lactamase 0.0029 0.0521 0.0595
Brugia malayi Bromodomain containing protein 0.0064 0.1391 0.1587
Leishmania major hypothetical protein, conserved 0.0013 0.0129 0.0194
Brugia malayi follicle stimulating hormone receptor 0.0214 0.5059 0.5772
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.002 0.0317 0.0385
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0013 0.014 0.017
Schistosoma mansoni hypothetical protein 0.0013 0.0129 0.0157
Echinococcus granulosus methyl CpG binding domain protein 2 0.0014 0.0165 0.0201
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0016 0.0201 0.0264
Entamoeba histolytica cysteine protease, putative 0.0021 0.0332 0.0436
Leishmania major hypothetical protein, conserved 0.002 0.0309 0.0465
Entamoeba histolytica hypothetical protein 0.0016 0.0201 0.0263
Brugia malayi Cathepsin L-like precursor 0.0027 0.0487 0.0556
Echinococcus granulosus calpain A 0.0011 0.0074 0.009
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0029 0.0521 0.0595
Schistosoma mansoni zinc finger protein 0.0018 0.0251 0.0305
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0016 0.0201 0.0201
Onchocerca volvulus 0.0029 0.0521 0.0521
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0014 0.0165 0.0216
Leishmania major cathepsin L-like protease 0.0041 0.082 0.1233
Brugia malayi multidrug resistance protein 3 0.002 0.0317 0.0362
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0041 0.082 0.082
Brugia malayi Cathepsin L-like precursor 0.0041 0.082 0.0935
Brugia malayi Isocitrate dehydrogenase 0.0013 0.014 0.0159
Loa Loa (eye worm) hypothetical protein 0.0111 0.2539 0.2896
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0111 0.2539 0.2896
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0111 0.2539 0.3084
Mycobacterium ulcerans deoxycytidine triphosphate deaminase 0.0111 0.2527 1
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.002 0.0312 0.0379
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0067 0.146 0.1774
Plasmodium vivax SET domain protein, putative 0.0053 0.1109 0.1455
Plasmodium falciparum ataxin-2 like protein, putative 0.002 0.0309 0.0406
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.002 0.0317 0.0317
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0051 0.1077 0.1308
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.002 0.0317 0.0317
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0034 0.0641 0.084
Mycobacterium ulcerans lipase LipD 0.0029 0.0521 0.1375
Brugia malayi Inositol-1 0.0034 0.0641 0.0731
Mycobacterium tuberculosis Probable deoxycytidine triphosphate deaminase Dcd (dCTP deaminase) 0.0111 0.2527 0.5697
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0011 0.0074 0.0112
Brugia malayi beta-lactamase 0.0029 0.0521 0.0595
Mycobacterium tuberculosis Conserved protein 0.0029 0.0521 0.0911
Trichomonas vaginalis ap endonuclease, putative 0.0016 0.0201 0.0201
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0083 0.186 0.226
Echinococcus multilocularis fetal alzheimer antigen, falz 0.002 0.0312 0.0379
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0053 0.1109 0.1455
Trichomonas vaginalis D-aminoacylase, putative 0.0029 0.0521 0.0521
Loa Loa (eye worm) hypothetical protein 0.0025 0.0425 0.0485
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0011 0.0074 0.0112
Trypanosoma cruzi cruzipain precursor, putative 0.0014 0.0147 0.0221
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.002 0.0317 0.0385
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0021 0.0332 0.0404
Echinococcus granulosus zinc finger protein 0.0018 0.0251 0.0305
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0034 0.0641 0.0641
Loa Loa (eye worm) hypothetical protein 0.0028 0.0503 0.0574
Toxoplasma gondii isocitrate dehydrogenase 0.0013 0.014 0.0183
Toxoplasma gondii transporter, cation channel family protein 0.0023 0.0385 0.0505
Trichomonas vaginalis D-aminoacylase, putative 0.0029 0.0521 0.0521
Toxoplasma gondii hypothetical protein 0.002 0.0316 0.0414
Echinococcus granulosus multidrug resistance protein 1 0.0014 0.0165 0.0201
Brugia malayi Cathepsin L-like precursor 0.0041 0.082 0.0935
Echinococcus multilocularis cysteine protease 0.0041 0.082 0.0996
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.003 0.0554 0.0989
Entamoeba histolytica cysteine proteinase, putative 0.0021 0.0332 0.0436
Echinococcus multilocularis ubiquitin conjugating enzyme E2 N 0.0279 0.6649 0.8079
Leishmania major cathepsin L-like protease 0.0113 0.2583 0.3885
Echinococcus multilocularis cpg binding protein 0.0027 0.0478 0.0581
Loa Loa (eye worm) hypothetical protein 0.0191 0.4503 0.5138
Echinococcus granulosus inositol monophosphatase 1 0.0034 0.0641 0.0778
Echinococcus multilocularis importin subunit beta 1 0.0019 0.0291 0.0353
Plasmodium vivax vivapain-2 0.0041 0.082 0.1075
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.002 0.0317 0.0317
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0113 0.2583 0.3885
Brugia malayi Pre-SET motif family protein 0.0365 0.8765 1
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.002 0.0317 0.0362
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0011 0.0074 0.0112
Chlamydia trachomatis deoxycytidine triphosphate deaminase 0.0111 0.2527 0.3023
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0111 0.2539 0.3084
Loa Loa (eye worm) hypothetical protein 0.0102 0.2305 0.2629
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.005 0.1041 0.1188
Trypanosoma cruzi cysteine proteinase, putative 0.0021 0.0332 0.05
Trypanosoma brucei hypothetical protein, conserved 0.0029 0.0521 0.0784
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0013 0.014 0.017
Mycobacterium tuberculosis Probable lipase LipD 0.0029 0.0521 0.0911
Mycobacterium leprae PROBABLE DEOXYCYTIDINE TRIPHOSPHATE DEAMINASE DCD (DCTP DEAMINASE) 0.0111 0.2527 1
Loa Loa (eye worm) transcription factor SMAD2 0.0096 0.2158 0.2462
Brugia malayi Cathepsin L-like precursor 0.0027 0.0487 0.0556
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0014 0.0165 0.0248
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0113 0.2583 0.3885
Loa Loa (eye worm) hypothetical protein 0.002 0.0317 0.0362
Schistosoma mansoni hypothetical protein 0.0162 0.379 0.4604
Loa Loa (eye worm) hypothetical protein 0.0023 0.0385 0.0439
Entamoeba histolytica hypothetical protein 0.0208 0.4915 0.6444
Echinococcus granulosus snurportin 1 0.0207 0.4898 0.5951
Trypanosoma cruzi cruzipain precursor, putative 0.0113 0.2583 0.3885
Entamoeba histolytica cysteine protease, putative 0.0021 0.0332 0.0436
Echinococcus multilocularis inositol monophosphatase 1 0.0034 0.0641 0.0778
Schistosoma mansoni ap endonuclease 0.0016 0.0201 0.0245
Brugia malayi Pre-SET motif family protein 0.0053 0.1109 0.1266
Schistosoma mansoni importin beta-1 0.0019 0.0291 0.0353
Leishmania major cathepsin L-like protease 0.0041 0.082 0.1233
Leishmania major GTP-binding protein, putative 0.0014 0.0165 0.0248
Mycobacterium ulcerans esterase/lipase LipP 0.0029 0.0521 0.1375
Loa Loa (eye worm) hypothetical protein 0.002 0.0317 0.0362
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.002 0.0317 0.0385
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0083 0.186 0.226
Loa Loa (eye worm) voltage-dependent calcium channel 0.0023 0.0385 0.0439
Echinococcus multilocularis beta LACTamase domain containing family member 0.0029 0.0521 0.0633
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0029 0.0534 0.0649
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.002 0.0317 0.0317
Echinococcus granulosus tm gpcr rhodopsin 0.0288 0.6877 0.8355
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.002 0.0317 0.0317
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0013 0.014 0.021
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0014 0.0147 0.0167
Loa Loa (eye worm) bromodomain containing protein 0.0015 0.0178 0.0203
Schistosoma mansoni methyl-cpg binding protein mbd 0.0014 0.0165 0.0201
Entamoeba histolytica hypothetical protein 0.0111 0.2527 0.3313
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0041 0.082 0.082
Loa Loa (eye worm) hypothetical protein 0.0037 0.0726 0.0828
Loa Loa (eye worm) hypothetical protein 0.0029 0.0521 0.0595
Brugia malayi calpain family protein 1 0.0028 0.0503 0.0574
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0034 0.0641 0.0963
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.002 0.0317 0.0317
Brugia malayi ubiquitin conjugating enzyme protein 13 0.0279 0.6649 0.7586
Loa Loa (eye worm) fibroinase 0.0041 0.082 0.0935
Schistosoma mansoni multidrug resistance protein 0.002 0.0317 0.0385
Schistosoma mansoni multidrug resistance protein 0.002 0.0317 0.0385
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0068 0.1472 0.2213
Entamoeba histolytica cysteine protease, putative 0.0021 0.0332 0.0436
Trypanosoma cruzi major cysteine proteinase, putative 0.008 0.1764 0.2652
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial precursor, putative 0.0319 0.7627 1
Echinococcus multilocularis zinc finger protein 0.0018 0.0251 0.0305
Trichomonas vaginalis ap endonuclease, putative 0.0016 0.0201 0.0201
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial precursor, putative 0.0319 0.7627 1
Onchocerca volvulus Cathepsin L homolog 0.0041 0.082 0.082
Entamoeba histolytica cysteine protease, putative 0.0021 0.0332 0.0436
Loa Loa (eye worm) hypothetical protein 0.0029 0.0521 0.0595
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0034 0.0641 0.0963
Trypanosoma cruzi ISWI complex protein 0.0013 0.0129 0.0194
Loa Loa (eye worm) hypothetical protein 0.0014 0.0147 0.0167
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0111 0.2539 0.3084
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0053 0.1109 0.1348
Brugia malayi beta-lactamase family protein 0.0029 0.0521 0.0595
Entamoeba histolytica cysteine proteinase, putative 0.0041 0.082 0.1075
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0113 0.2583 0.3885
Schistosoma mansoni inositol monophosphatase 0.0034 0.0641 0.0778
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0021 0.0332 0.0332
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0041 0.082 0.0996
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0041 0.082 0.082
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0021 0.0332 0.0404
Toxoplasma gondii ubiquitin-conjugating enzyme subfamily protein 0.0279 0.6649 0.8718
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0011 0.0074 0.0112
Schistosoma mansoni cathepsin F (C01 family) 0.0041 0.082 0.0996
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0081 0.0093
Brugia malayi Cathepsin L-like precursor 0.0041 0.082 0.0935
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.002 0.0317 0.0385
Plasmodium vivax vivapain-3 0.0021 0.0332 0.0436
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0034 0.0641 0.1889
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.0319 0.7627 1
Plasmodium vivax unspecified product 0.0021 0.0332 0.0436
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0014 0.0165 0.0165
Loa Loa (eye worm) hypothetical protein 0.0027 0.0487 0.0556
Plasmodium falciparum deoxyuridine 5'-triphosphate nucleotidohydrolase 0.0319 0.7627 1
Schistosoma mansoni bromodomain containing protein 0.0054 0.115 0.1398
Echinococcus multilocularis isocitrate dehydrogenase 0.0013 0.014 0.017
Schistosoma mansoni methyl-cpg binding protein mbd 0.0014 0.0165 0.0201
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0008 0.001
Onchocerca volvulus Cathepsin F homolog 0.0041 0.082 0.082
Entamoeba histolytica cysteine proteinase, putative 0.0021 0.0332 0.0436
Trichomonas vaginalis ABC transporter, putative 0.002 0.0317 0.0317
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.002 0.0317 0.0317
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.002 0.0317 0.0423
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0008 0.001
Echinococcus granulosus cysteine protease 0.0021 0.0332 0.0404
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0029 0.0521 0.0633
Schistosoma mansoni peptidylglycine monooxygenase 0.0102 0.2305 0.28
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0111 0.2539 0.3084
Plasmodium falciparum multidrug resistance protein 1 0.002 0.0317 0.0416
Trypanosoma cruzi PAB1-binding protein , putative 0.002 0.0309 0.0465
Mycobacterium ulcerans beta-lactamase 0.0029 0.0521 0.1375
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0041 0.082 0.0996
Schistosoma mansoni hypothetical protein 0.0009 0.0036 0.0044
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0041 0.082 0.082
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0016 0.0201 0.023
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0083 0.186 0.226
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.002 0.0317 0.0317
Echinococcus multilocularis calpain 5 0.0011 0.0074 0.009
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0083 0.186 0.226
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0099 0.2251 0.3385
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0051 0.1077 0.1308
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.002 0.0317 0.0385
Schistosoma mansoni dopamine-beta-monooxygenase 0.0102 0.2305 0.28
Trichomonas vaginalis ABC transporter, putative 0.002 0.0317 0.0317
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0041 0.082 0.0935
Schistosoma mansoni calpain-7 (C02 family) 0.0011 0.0074 0.009
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0041 0.082 0.0935
Trichomonas vaginalis abcb9, putative 0.002 0.0317 0.0317
Trichomonas vaginalis penicillin-binding protein, putative 0.0029 0.0521 0.0521
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0041 0.082 0.082
Entamoeba histolytica cysteine proteinase, putative 0.0021 0.0332 0.0436
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0016 0.0201 0.0303
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0279 0.6649 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0016 0.0201 0.0303
Entamoeba histolytica Ran family GTPase 0.0014 0.0165 0.0216
Loa Loa (eye worm) hypothetical protein 0.0029 0.0521 0.0595
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.002 0.0317 0.0385
Brugia malayi Papain family cysteine protease containing protein 0.0021 0.0332 0.0379
Trichomonas vaginalis ABC transporter, putative 0.002 0.0317 0.0317
Onchocerca volvulus 0.0041 0.082 0.082
Loa Loa (eye worm) hypothetical protein 0.0019 0.0291 0.0332
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0041 0.082 0.082
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0041 0.082 0.082
Plasmodium vivax ubiquitin-conjugating enzyme E2 N, putative 0.0279 0.6649 0.8718
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.002 0.0317 0.0385
Plasmodium vivax vivapain-2 0.0041 0.082 0.1075
Loa Loa (eye worm) PHD-finger family protein 0.0017 0.0239 0.0273
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0041 0.082 0.082
Echinococcus granulosus voltage dependent calcium channel 0.0111 0.2539 0.3084
Echinococcus granulosus cathepsin l1 0.0041 0.082 0.0996
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0029 0.0534 0.0649
Brugia malayi Papain family cysteine protease containing protein 0.0041 0.082 0.0935
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0011 0.0074 0.0112
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0013 0.014 0.0183
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0113 0.2583 0.3885
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0014 0.0165 0.8188
Loa Loa (eye worm) hypothetical protein 0.002 0.0316 0.0361
Entamoeba histolytica P-glycoprotein-5 0.002 0.0317 0.0416
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0009 0.0036 0.0044
Entamoeba histolytica cysteine protease, putative 0.0021 0.0332 0.0436
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0014 0.0165 0.0201
Entamoeba histolytica cysteine proteinase 1, putative 0.0021 0.0332 0.0436
Entamoeba histolytica P-glycoprotein 5, putative 0.002 0.0317 0.0416
Echinococcus granulosus beta LACTamase domain containing family member 0.0029 0.0521 0.0633
Entamoeba histolytica cysteine protease, putative 0.0021 0.0332 0.0436
Loa Loa (eye worm) hypothetical protein 0.002 0.0311 0.0355
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0041 0.082 0.082
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.002 0.0311 0.0378
Leishmania major hypothetical protein, conserved 0.0029 0.0521 0.0784
Echinococcus multilocularis multidrug resistance protein 1 0.002 0.0317 0.0385
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.002 0.0317 0.0317
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0365 0.8765 1
Trypanosoma brucei calpain-like protein, putative 0.0011 0.0074 0.0112
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0013 0.014 0.017
Schistosoma mansoni calpain-7 (C02 family) 0.0011 0.0074 0.009
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0034 0.0641 0.0963
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0041 0.082 0.082
Onchocerca volvulus 0.0024 0.0405 0.0405
Loa Loa (eye worm) hypothetical protein 0.0029 0.0521 0.0595
Brugia malayi hypothetical protein 0.002 0.0309 0.0353
Entamoeba histolytica hypothetical protein 0.0208 0.4915 0.6444
Toxoplasma gondii cathepsin CPL 0.0041 0.082 0.1075
Echinococcus multilocularis ATP binding cassette sub family B 0.002 0.0311 0.0378
Trichomonas vaginalis ABC transporter, half transporter, putative 0.002 0.0317 0.0317
Brugia malayi Cathepsin L-like precursor 0.0014 0.0147 0.0167
Schistosoma mansoni ran 0.0014 0.0165 0.02
Mycobacterium tuberculosis Conserved protein 0.0029 0.0521 0.0911
Trichomonas vaginalis D-aminoacylase, putative 0.0029 0.0521 0.0521
Brugia malayi MH2 domain containing protein 0.0096 0.2158 0.2462
Echinococcus multilocularis hypothetical protein 0.0011 0.0074 0.009
Loa Loa (eye worm) hypothetical protein 0.0014 0.0147 0.0167
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0008 0.001
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0016 0.0201 0.0148
Loa Loa (eye worm) hypothetical protein 0.0059 0.127 0.1449
Loa Loa (eye worm) calpain family protein 1 0.0028 0.0503 0.0574
Plasmodium vivax vivapain-1 0.0021 0.0332 0.0436
Trypanosoma cruzi hypothetical protein, conserved 0.0029 0.0521 0.0784
Loa Loa (eye worm) hypothetical protein 0.0032 0.0604 0.0689
Plasmodium vivax importin-beta 2, putative 0.0019 0.0291 0.0381
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0016 0.0201 0.0264
Leishmania major cathepsin L-like protease 0.0041 0.082 0.1233
Schistosoma mansoni calpain (C02 family) 0.0011 0.0074 0.009
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0008 0.001
Echinococcus granulosus calpain 0.0011 0.0074 0.009
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0113 0.2583 0.3885
Trichomonas vaginalis inositol monophosphatase, putative 0.0034 0.0641 0.0641
Loa Loa (eye worm) isocitrate dehydrogenase 0.0013 0.014 0.0159
Onchocerca volvulus 0.0041 0.082 0.082
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.002 0.0317 0.0477
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0041 0.082 0.082
Toxoplasma gondii histone lysine methyltransferase SET1 0.005 0.103 0.135
Schistosoma mansoni cathepsin F (C01 family) 0.0027 0.0487 0.0592
Echinococcus multilocularis calpain family protein 1, d 0.0021 0.0321 0.0391
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0011 0.0074 0.0112
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0014 0.0165 0.0216
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0041 0.082 0.082
Echinococcus granulosus cathepsin L 0.0021 0.0332 0.0404
Loa Loa (eye worm) cysteine protease 0.0041 0.082 0.0935
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0041 0.082 0.082
Echinococcus granulosus calpain 7 C02 family 0.0011 0.0074 0.009
Entamoeba histolytica cysteine proteinase, putative 0.0021 0.0332 0.0436
Schistosoma mansoni smdr2 0.002 0.0317 0.0385
Entamoeba histolytica cysteine proteinase, putative 0.0041 0.082 0.1075
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.003 0.0554 0.0673
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0083 0.186 0.2122
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0191 0.4503 0.5138
Entamoeba histolytica cysteine protease, putative 0.0021 0.0332 0.0436
Trypanosoma brucei calpain-like protein, putative 0.0011 0.0074 0.0112
Loa Loa (eye worm) calpain family protein 1 0.0021 0.0321 0.0367
Plasmodium falciparum cysteine proteinase falcipain 1 0.0021 0.0332 0.0436
Loa Loa (eye worm) hypothetical protein 0.0067 0.146 0.1666
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0083 0.186 0.226
Loa Loa (eye worm) hypothetical protein 0.0029 0.0521 0.0595
Echinococcus multilocularis calpain 0.0011 0.0074 0.009
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0288 0.6877 0.8355
Entamoeba histolytica cysteine protease, putative 0.0021 0.0332 0.0436
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.002 0.0317 0.0317
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0016 0.0201 0.0264
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0487 0.0487
Echinococcus granulosus histone lysine methyltransferase setb 0.0067 0.146 0.1774
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0011 0.0074 0.0112
Echinococcus granulosus cathepsin l cysteine peptidase 0.0041 0.082 0.0996
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0041 0.082 0.082
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0013 0.014 0.021
Entamoeba histolytica cysteine protease, putative 0.0021 0.0332 0.0436
Loa Loa (eye worm) hypothetical protein 0.0041 0.082 0.0935
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0021 0.0332 0.05
Trypanosoma cruzi hypothetical protein, conserved 0.0029 0.0521 0.0784
Echinococcus granulosus peptidyl glycine alpha amidating monooxygenase 0.0191 0.4503 0.5471
Schistosoma mansoni hypothetical protein 0.0207 0.4898 0.5951
Trichomonas vaginalis ABC transporter, half transporter, putative 0.002 0.0317 0.0317
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0067 0.146 0.1774
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0016 0.0201 0.0303
Mycobacterium tuberculosis Conserved protein 0.0029 0.0521 0.0911
Echinococcus granulosus multidrug resistance protein 1 0.0014 0.0165 0.0201
Loa Loa (eye worm) hypothetical protein 0.0027 0.0487 0.0556
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.0319 0.7627 1
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0279 0.6649 0.6649
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.003 0.0554 0.0164
Echinococcus granulosus cpg binding protein 0.0027 0.0478 0.0581
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0034 0.0641 0.084
Plasmodium falciparum ubiquitin-conjugating enzyme E2 N, putative 0.0279 0.6649 0.8718
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0113 0.2583 0.3885
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0011 0.0074 0.0112
Mycobacterium ulcerans hypothetical protein 0.0029 0.0521 0.1375
Echinococcus granulosus cathepsin l1 0.0027 0.0487 0.0592
Loa Loa (eye worm) hypothetical protein 0.002 0.0309 0.0353
Brugia malayi Copper type II ascorbate-dependent monooxygenase, N-terminal domain containing protein 0.0052 0.1078 0.123
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0011 0.0074 0.0112
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.003 0.0554 0.0673
Loa Loa (eye worm) hypothetical protein 0.002 0.0316 0.0361
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0014 0.0165 0.0188
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.002 0.0317 0.0317
Onchocerca volvulus 0.0041 0.082 0.082
Plasmodium falciparum ataxin-2 like protein, putative 0.002 0.0309 0.0406
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase, putative 0.0111 0.2527 0.3313
Onchocerca volvulus Cathepsin L homolog 0.0041 0.082 0.082
Plasmodium vivax unspecified product 0.0014 0.0147 0.0192
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0207 0.4898 0.5588
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0034 0.0641 0.0963
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0184 0.433 1
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0279 0.6649 0.7586
Brugia malayi exodeoxyribonuclease III family protein 0.0016 0.0201 0.023
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0041 0.082 0.082
Mycobacterium ulcerans deoxyuridine 5'-triphosphate nucleotidohydrolase 0.0111 0.2527 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0021 0.0332 0.05
Loa Loa (eye worm) hypothetical protein 0.0017 0.0243 0.0278
Brugia malayi Cathepsin L-like cysteine proteinase 0.0027 0.0487 0.0556
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.002 0.0317 0.0385
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0279 0.6649 0.7586
Echinococcus granulosus multidrug resistance protein 1 0.002 0.0317 0.0385
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.002 0.0317 0.0317
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0014 0.0165 0.0248
Toxoplasma gondii exonuclease III APE 0.0016 0.0201 0.0264
Schistosoma mansoni cpg binding protein 0.0024 0.0405 0.0493
Echinococcus multilocularis dnaJ subfamily B 0.0343 0.8231 1
Entamoeba histolytica P-glycoprotein-2, putative 0.002 0.0317 0.0416
Trypanosoma cruzi cysteine protease, putative 0.0021 0.0332 0.05
Echinococcus granulosus ubiquitin conjugating enzyme E2 N 0.0279 0.6649 0.8079
Echinococcus multilocularis sodium channel protein 0.0047 0.097 0.1179
Trypanosoma brucei ISWI complex protein 0.0013 0.0129 0.0194
Loa Loa (eye worm) hypothetical protein 0.0029 0.0521 0.0595
Echinococcus multilocularis calpain 7 (C02 family) 0.0011 0.0074 0.009
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.0319 0.7627 1
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0013 0.014 0.021
Wolbachia endosymbiont of Brugia malayi dUTPase 0.0319 0.7627 1
Loa Loa (eye worm) calcium channel 0.0111 0.2539 0.2896
Loa Loa (eye worm) calpain 0.0011 0.0074 0.0085
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0113 0.2583 0.3885
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0014 0.0165 0.02
Brugia malayi isocitrate dehydrogenase 0.0013 0.014 0.0159
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0021 0.0332 0.0404
Trypanosoma cruzi cysteine peptidase, putative 0.0021 0.0332 0.05
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.002 0.0317 0.0317
Plasmodium vivax calpain, putative 0.0011 0.0074 0.0097
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0014 0.0165 0.0188
Toxoplasma gondii ABC1 family protein 0.0029 0.0521 0.0683
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0041 0.082 0.082
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0011 0.0074 0.0112
Schistosoma mansoni ap endonuclease 0.0016 0.0201 0.0245
Onchocerca volvulus 0.0027 0.0487 0.0487
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0111 0.2539 0.3084
Schistosoma mansoni cathepsin F (C01 family) 0.0041 0.082 0.0996
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.002 0.0317 0.0317
Brugia malayi dUTP diphosphatase 0.0319 0.7627 0.8701
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0067 0.146 0.1774
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.002 0.0317 0.0385
Echinococcus multilocularis cysteine protease 0.0041 0.082 0.0996
Schistosoma mansoni Mername-AA248 (C02 family) 0.0011 0.0074 0.009
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0014 0.0165 0.0248
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0021 0.0332 0.05
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0014 0.0165 0.0216
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0053 0.1115 0.1355
Brugia malayi ABC transporter family protein 0.002 0.0317 0.0362
Entamoeba histolytica cysteine proteinase, putative 0.0027 0.0487 0.0639
Loa Loa (eye worm) dUTP diphosphatase 0.0319 0.7627 0.8701
Entamoeba histolytica P-glyco protein 6, putative 0.002 0.0317 0.0416
Mycobacterium tuberculosis Probable lipase LipE 0.0029 0.0521 0.0911
Trichomonas vaginalis abcb9, putative 0.002 0.0317 0.0317
Onchocerca volvulus 0.0041 0.082 0.082
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0041 0.082 0.082
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0014 0.0147 0.0167
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0083 0.186 0.226
Echinococcus multilocularis cathepsin L cysteine protease 0.0041 0.082 0.0996
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0029 0.0521 0.0911
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0041 0.082 0.1075
Brugia malayi Cathepsin L-like precursor 0.0041 0.082 0.0935
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0011 0.0074 0.0112
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0011 0.0074 0.0112
Schistosoma mansoni deoxyuridine 5'-triphosphate nucleotidohydrolase 0.0319 0.7627 0.9266
Trichomonas vaginalis abcb9, putative 0.002 0.0317 0.0317
Echinococcus multilocularis cathepsin L 0.0021 0.0332 0.0404
Echinococcus granulosus cathepsin L cysteine protease 0.0021 0.0332 0.0404
Schistosoma mansoni voltage-gated cation channel 0.0111 0.2539 0.3084
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0016 0.0201 0.0201
Brugia malayi Bromodomain containing protein 0.0032 0.0603 0.0687
Trypanosoma brucei ubiquitin-protein ligase, putative 0.0279 0.6649 1
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0011 0.0074 0.0112
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0214 0.5059 0.5772
Brugia malayi Papain family cysteine protease containing protein 0.0021 0.0332 0.0379
Trichomonas vaginalis ABC transporter, putative 0.002 0.0317 0.0317
Echinococcus multilocularis multidrug resistance protein 1 0.0014 0.0165 0.0201
Entamoeba histolytica cysteine protease, putative 0.0021 0.0332 0.0436
Entamoeba histolytica cysteine protease, putative 0.0021 0.0332 0.0436
Brugia malayi PHD-finger family protein 0.0022 0.0361 0.0412
Schistosoma mansoni hypothetical protein 0.0162 0.379 0.4604
Schistosoma mansoni hypothetical protein 0.0017 0.0239 0.029
Echinococcus multilocularis snurportin 1 0.0207 0.4898 0.5951
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.0319 0.7627 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0016 0.0201 1
Trichomonas vaginalis esterase, putative 0.0029 0.0521 0.0521
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0041 0.082 0.082
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0113 0.2583 0.3885
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0013 0.014 0.017
Trichomonas vaginalis ran, putative 0.0014 0.0165 0.0165
Trichomonas vaginalis deoxyuridine 5'-triphosphate nucleotidohydrolase, putative 0.0319 0.7627 0.7627
Brugia malayi Importin beta-1 subunit 0.0019 0.0291 0.0332
Toxoplasma gondii HEAT repeat-containing protein 0.0019 0.0291 0.0381
Echinococcus multilocularis voltage dependent calcium channel 0.0111 0.2539 0.3084
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0041 0.082 0.082
Trypanosoma brucei calpain-like protein, putative 0.0011 0.0074 0.0112
Treponema pallidum deoxyuridine 5'-triphosphate nucleotidohydrolase (dut) 0.0319 0.7627 1
Plasmodium vivax ataxin-2 like protein, putative 0.002 0.0309 0.0406
Brugia malayi calpain 7 0.0011 0.0074 0.0085
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0011 0.0074 0.0112
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0279 0.6649 0.6649
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0113 0.2583 0.3885
Onchocerca volvulus 0.002 0.0317 0.0317
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0009 0.0036 0.0044
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0041 0.082 0.082
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0008 0.001
Echinococcus multilocularis dUTP pyrophosphatase 0.0319 0.7627 0.9266
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0521 0.0683
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0044 0.0051
Trypanosoma cruzi ISWI complex protein 0.0013 0.0129 0.0194
Toxoplasma gondii isocitrate dehydrogenase 0.0013 0.014 0.0183
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0013 0.014 0.017
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0083 0.186 0.226
Schistosoma mansoni peptidyl-glycine monooxygenase 0.0191 0.4503 0.5471
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0011 0.0074 0.0112
Plasmodium vivax deoxyuridine 5'-triphosphate nucleotidohydrolase, putative 0.0319 0.7627 1
Leishmania major cathepsin L-like protease 0.0113 0.2583 0.3885
Trypanosoma brucei calpain-like protein, putative 0.0011 0.0074 0.0112
Brugia malayi cathepsin L-like precursor 0.0027 0.0487 0.0556
Trypanosoma cruzi importin beta-1 subunit, putative 0.0016 0.0201 0.0302
Echinococcus granulosus voltage dependent calcium channel 0.0023 0.0385 0.0468
Schistosoma mansoni inositol monophosphatase 0.0034 0.0641 0.0778
Entamoeba histolytica P-glycoprotein-2 0.002 0.0317 0.0416
Echinococcus multilocularis geminin 0.0162 0.379 0.4604
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0041 0.082 0.082
Trichomonas vaginalis importin beta-1, putative 0.0016 0.0201 0.0201
Schistosoma mansoni cpg binding protein 0.0027 0.0478 0.0581
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0034 0.0641 0.0641
Entamoeba histolytica cysteine proteinase 2 0.0021 0.0332 0.0436
Onchocerca volvulus 0.0041 0.082 0.082
Echinococcus multilocularis voltage dependent calcium channel 0.0111 0.2539 0.3084
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0029 0.0534 0.0649
Plasmodium falciparum importin beta, putative 0.0019 0.0291 0.0381
Loa Loa (eye worm) ctsf protein 0.0041 0.082 0.0935
Mycobacterium tuberculosis Probable hydrolase 0.0029 0.0521 0.0911
Onchocerca volvulus 0.0053 0.1109 0.1109
Loa Loa (eye worm) inositol-1 0.0034 0.0641 0.0731
Brugia malayi CXXC zinc finger family protein 0.0024 0.0405 0.0463
Trypanosoma cruzi cysteine peptidase, putative 0.0113 0.2583 0.3885
Onchocerca volvulus 0.0041 0.082 0.082
Trypanosoma brucei importin beta-1 subunit, putative 0.0019 0.0291 0.0437
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.002 0.0317 0.0416
Leishmania major cathepsin L-like protease 0.0041 0.082 0.1233
Toxoplasma gondii deoxyuridine 5'-triphosphate nucleotidohydrolase, putative 0.0319 0.7627 1
Leishmania major cysteine peptidase A (CPA) 0.0041 0.082 0.1233
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0016 0.0201 0.0303
Echinococcus granulosus multidrug resistance protein 1 0.002 0.0317 0.0385
Echinococcus granulosus importin subunit beta 1 0.0019 0.0291 0.0353
Chlamydia trachomatis deoxyuridine 5'-triphosphate nucleotidohydrolase 0.0319 0.7627 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0113 0.2583 0.3885
Loa Loa (eye worm) CXXC zinc finger family protein 0.0024 0.0405 0.0463
Brugia malayi Ubiquitin conjugating enzyme protein 13 0.0279 0.6649 0.7586
Onchocerca volvulus 0.0029 0.0521 0.0521
Echinococcus multilocularis multidrug resistance protein 1 0.002 0.0317 0.0385
Entamoeba histolytica cysteine protease, putative 0.0021 0.0332 0.0436
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0044 0.0054
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0041 0.082 0.1075
Trypanosoma cruzi cysteine peptidase, putative 0.0041 0.082 0.1233
Brugia malayi cathepsin F-like cysteine proteinase 0.0014 0.0147 0.0167
Entamoeba histolytica hypothetical protein 0.0319 0.7627 1
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0111 0.2539 0.3084
Trypanosoma brucei antigen, putative 0.0011 0.0074 0.0112
Entamoeba histolytica P-glycoprotein-2 0.002 0.0317 0.0416
Trichomonas vaginalis penicillin-binding protein, putative 0.0029 0.0521 0.0521
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.002 0.0317 0.0317
Schistosoma mansoni ran 0.0014 0.0165 0.02
Loa Loa (eye worm) MH2 domain-containing protein 0.0096 0.2158 0.2462
Brugia malayi hypothetical protein 0.0013 0.0134 0.0153
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0487 0.0487
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0111 0.2539 0.3084
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0016 0.0201 0.0245
Toxoplasma gondii LsmAD domain-containing protein 0.002 0.0309 0.0406
Schistosoma mansoni cpg binding protein 0.0027 0.0478 0.0581
Loa Loa (eye worm) hypothetical protein 0.0021 0.0321 0.0367
Schistosoma mansoni calpain C (C02 family) 0.0011 0.0074 0.009

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 44.6684 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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