Detailed information for compound 1416610

Basic information

Technical information
  • TDR Targets ID: 1416610
  • Name: N-(4-diethylaminophenyl)-3-methyl-6-phenylimi dazo[2,1-b][1,3]thiazole-2-carboxamide
  • MW: 404.528 | Formula: C23H24N4OS
  • H donors: 1 H acceptors: 2 LogP: 5.95 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(c1ccc(cc1)NC(=O)c1sc2n(c1C)cc(n2)c1ccccc1)CC
  • InChi: 1S/C23H24N4OS/c1-4-26(5-2)19-13-11-18(12-14-19)24-22(28)21-16(3)27-15-20(25-23(27)29-21)17-9-7-6-8-10-17/h6-15H,4-5H2,1-3H3,(H,24,28)
  • InChiKey: DSMUWGYKIYKUPD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(4-diethylaminophenyl)-3-methyl-6-phenyl-imidazo[2,1-b]thiazole-2-carboxamide
  • N-(4-diethylaminophenyl)-3-methyl-6-phenyl-2-imidazo[2,1-b]thiazolecarboxamide
  • N-(4-diethylaminophenyl)-3-methyl-6-phenyl-imidazo[2,1-b][1,3]thiazole-2-carboxamide
  • G677-0006
  • NCGC00132926-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens bromodomain adjacent to zinc finger domain, 2B Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K01549 ATP synthase [EC3.6.3.14], putative Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Conserved hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma mansoni bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Brugia malayi Bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum expressed protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Schistosoma japonicum hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum Cleft lip and palate transmembrane protein 1-like protein, putative Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable lipase LipD 0.0106 0.1101 0.1343
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0106 0.1101 0.3152
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.0267 0.0267
Trypanosoma brucei hypothetical protein, conserved 0.0106 0.1101 1
Echinococcus multilocularis inhibitor of apoptosis protein 0.0053 0.0453 0.0453
Loa Loa (eye worm) hypothetical protein 0.0109 0.1131 0.297
Schistosoma mansoni importin beta-1 0.003 0.0175 0.0175
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0265 0.3051 0.3051
Plasmodium vivax importin-beta 2, putative 0.003 0.0175 0.1179
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0105 0.0086
Trypanosoma cruzi ISWI complex protein 0.0018 0.0029 0.0119
Trichomonas vaginalis bromodomain-containing protein, putative 0.009 0.0902 0.2546
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.005 0.041 0.1099
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.0267 0.0593
Brugia malayi latrophilin 2 splice variant baaae 0.0074 0.0711 0.2019
Trypanosoma cruzi hypothetical protein, conserved 0.0106 0.1101 1
Brugia malayi Pre-SET motif family protein 0.0037 0.026 0.0709
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0109 0.1131 0.324
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0037 0.026 0.1872
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0127 0.136 0.136
Mycobacterium tuberculosis Probable lipase LipE 0.0106 0.1101 0.1343
Echinococcus granulosus lamin dm0 0.0033 0.0202 0.0202
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0202 0.0539
Brugia malayi intermediate filament protein 0.0033 0.0202 0.0539
Schistosoma mansoni myelin transcription factor 1 myt1 0.0056 0.0494 0.0494
Loa Loa (eye worm) hypothetical protein 0.0074 0.0711 0.1851
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0099 0.1019 0.1019
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.009 0.0902 0.2546
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0043 0.0334 0.0334
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0139 0.1506 1
Loa Loa (eye worm) CYP4Cod1 0.0026 0.0123 0.0283
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0299 0.3457 0.3457
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0226 0.2574 0.6816
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0139 0.1506 0.1844
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0051 0.0051
Echinococcus multilocularis musashi 0.0033 0.0202 0.0202
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0267 0.2312
Schistosoma mansoni hypothetical protein 0.0025 0.0108 0.0108
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0299 0.3457 0.3457
Echinococcus granulosus zinc finger protein 0.0034 0.0223 0.0223
Schistosoma mansoni inositol monophosphatase 0.0038 0.0267 0.0267
Echinococcus multilocularis microtubule associated protein 2 0.0833 1 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0074 0.0707 0.184
Schistosoma mansoni hypothetical protein 0.0034 0.0225 0.0225
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.009 0.0902 0.6803
Loa Loa (eye worm) PHD-finger family protein 0.0025 0.0108 0.0244
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0195 0.2194 0.2194
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0077 0.0555
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0324 0.3769 1
Echinococcus multilocularis lamin 0.0033 0.0202 0.0202
Echinococcus granulosus snurportin 1 0.0324 0.3769 0.3769
Plasmodium vivax SET domain protein, putative 0.0037 0.026 0.1994
Echinococcus granulosus p2X purinoceptor 4 0.0686 0.8199 0.8199
Onchocerca volvulus 0.005 0.041 0.1099
Brugia malayi RNA, U transporter 1 0.0086 0.086 0.2451
Loa Loa (eye worm) hypothetical protein 0.002 0.0051 0.0092
Schistosoma mansoni lamin 0.0033 0.0202 0.0202
Trichomonas vaginalis D-aminoacylase, putative 0.0106 0.1101 0.3159
Leishmania major GTP-binding protein, putative 0.0022 0.0077 0.0555
Schistosoma mansoni inhibitor of apoptosis protein 0.0053 0.0453 0.0453
Brugia malayi acetyltransferase, GNAT family protein 0.0299 0.3457 1
Schistosoma mansoni cpg binding protein 0.0065 0.0599 0.0599
Echinococcus multilocularis cpg binding protein 0.0065 0.0599 0.0599
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.0267 0.0588
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0184 0.2057 0.2057
Onchocerca volvulus Deterin homolog 0.0053 0.0453 0.123
Echinococcus granulosus SAM and MBT domain containing protein 0.005 0.041 0.041
Brugia malayi PHD-finger family protein 0.0041 0.0302 0.0828
Plasmodium falciparum ataxin-2 like protein, putative 0.0077 0.0744 0.9516
Plasmodium vivax hypothetical protein, conserved 0.0106 0.1101 1
Trypanosoma cruzi cytochrome P450, putative 0.0026 0.0123 0.0978
Schistosoma mansoni sex comb on midleg homolog 0.005 0.041 0.041
Loa Loa (eye worm) CXXC zinc finger family protein 0.0059 0.0529 0.1367
Echinococcus multilocularis importin subunit beta 1 0.003 0.0175 0.0175
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0051 0.0051
Echinococcus granulosus fetal alzheimer antigen falz 0.0031 0.0178 0.0178
Echinococcus granulosus cytochrome P450 2K1 0.0017 0.0017 0.0017
Onchocerca volvulus 0.0033 0.0202 0.0462
Schistosoma mansoni rab6-interacting 0.002 0.0051 0.0051
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0267 0.2312
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0202 0.0494
Leishmania major hypothetical protein, conserved 0.0106 0.1101 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.1567 0.4133
Loa Loa (eye worm) hypothetical protein 0.0106 0.1101 0.289
Schistosoma mansoni hypothetical protein 0.0017 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0053 0.0453 0.1164
Loa Loa (eye worm) histone methyltransferase 0.002 0.0044 0.0074
Schistosoma mansoni cytochrome P450 0.0017 0.0017 0.0017
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0224 0.0224
Brugia malayi hypothetical protein 0.002 0.0051 0.01
Brugia malayi beta-lactamase 0.0106 0.1101 0.3152
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0106 0.1101 0.1101
Trypanosoma cruzi ISWI complex protein 0.0018 0.0029 0.0119
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0058 0.0512 0.0512
Schistosoma mansoni hypothetical protein 0.0164 0.1813 0.1813
Loa Loa (eye worm) doublecortin family protein 0.002 0.0051 0.0092
Loa Loa (eye worm) hypothetical protein 0.003 0.0175 0.0422
Loa Loa (eye worm) hypothetical protein 0.0053 0.0453 0.1164
Brugia malayi beta-lactamase family protein 0.0106 0.1101 0.3152
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0175 0.1459
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0031 0.0178 0.0178
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0184 0.2057 0.2057
Echinococcus multilocularis polycomb protein SCMH1 0.005 0.041 0.041
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0053 0.0453 0.1269
Loa Loa (eye worm) hypothetical protein 0.0056 0.0494 0.1272
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.0219 0.025
Brugia malayi Cytochrome P450 family protein 0.0026 0.0123 0.0308
Loa Loa (eye worm) beta-lactamase 0.0106 0.1101 0.289
Onchocerca volvulus 0.0287 0.3319 1
Schistosoma mansoni hypothetical protein 0.042 0.4941 0.4941
Trichomonas vaginalis esterase, putative 0.0106 0.1101 0.3159
Brugia malayi Importin beta-1 subunit 0.003 0.0175 0.046
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0285 0.329 1
Mycobacterium tuberculosis Conserved protein 0.0106 0.1101 0.1343
Schistosoma mansoni hypothetical protein 0.0034 0.0224 0.0224
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0077 0.0077
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0077 0.0462
Echinococcus multilocularis geminin 0.0164 0.1813 0.1813
Schistosoma mansoni P2X receptor subunit 0.0686 0.8199 0.8199
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0053 0.0453 0.0453
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0056 0.0494 0.1388
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0051 0.0051
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0077 0.0245
Schistosoma mansoni intermediate filament proteins 0.0033 0.0202 0.0202
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0017 0.0001
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0106 0.1101 0.1343
Brugia malayi Subtilase family protein 0.0265 0.3051 0.8821
Loa Loa (eye worm) hypothetical protein 0.0058 0.0512 0.1321
Leishmania major cytochrome p450-like protein 0.0026 0.0123 0.0978
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0056 0.0494 0.0494
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0099 0.1019 0.1019
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0678 0.8094 1
Brugia malayi Bromodomain containing protein 0.0053 0.0458 0.1283
Brugia malayi Cytochrome P450 family protein 0.0074 0.0707 0.2006
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0228 0.0228
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0224 0.0601
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.009 0.0902 0.6803
Echinococcus multilocularis p2X purinoceptor 4 0.0686 0.8199 0.8199
Schistosoma mansoni hypothetical protein 0.0053 0.0453 0.0453
Brugia malayi beta-lactamase family protein 0.0106 0.1101 0.3152
Plasmodium falciparum importin beta, putative 0.003 0.0175 0.1701
Onchocerca volvulus 0.0059 0.0529 0.1464
Plasmodium falciparum ataxin-2 like protein, putative 0.0077 0.0744 0.9516
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0106 0.1101 0.1343
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0285 0.329 1
Toxoplasma gondii ABC1 family protein 0.0106 0.1101 0.8329
Entamoeba histolytica acetyltransferase, GNAT family 0.008 0.0779 0.2185
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0053 0.0453 0.0453
Trypanosoma brucei ISWI complex protein 0.0018 0.0029 0.0119
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0121 0.1285 0.1285
Brugia malayi hypothetical protein 0.002 0.0051 0.01
Loa Loa (eye worm) hypothetical protein 0.0062 0.0564 0.1458
Loa Loa (eye worm) hypothetical protein 0.0077 0.0744 0.1938
Echinococcus granulosus methyl CpG binding domain protein 2 0.0021 0.0055 0.0055
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0034 0.0219 0.1357
Loa Loa (eye worm) hypothetical protein 0.0106 0.1101 0.289
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0021 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.0106 0.1101 0.289
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0038 0.0267 0.1683
Brugia malayi hypothetical protein 0.005 0.041 0.1145
Loa Loa (eye worm) hypothetical protein 0.005 0.041 0.1049
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0195 0.2194 0.2194
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0038 0.0267 0.5
Echinococcus multilocularis beta LACTamase domain containing family member 0.0106 0.1101 0.1101
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0267 0.0588
Plasmodium vivax ataxin-2 like protein, putative 0.0077 0.0744 0.6596
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0121 0.1285 0.1285
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0055 0.0055
Schistosoma mansoni hypothetical protein 0.0034 0.0224 0.0224
Loa Loa (eye worm) hypothetical protein 0.0056 0.0494 0.1273
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0184 0.2057 0.2057
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.329 0.9908
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0058 0.0512 0.0512
Echinococcus multilocularis SAM and MBT domain containing protein 0.005 0.041 0.041
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0026 0.0123 0.0712
Loa Loa (eye worm) hypothetical protein 0.0106 0.1101 0.289
Mycobacterium tuberculosis Conserved protein 0.0106 0.1101 0.1343
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0184 0.2057 0.2057
Schistosoma mansoni ran 0.0022 0.0077 0.0077
Loa Loa (eye worm) MBCTL1 0.0056 0.0494 0.1273
Echinococcus multilocularis zinc finger protein 0.0034 0.0223 0.0223
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0077 0.0077
Schistosoma mansoni cpg binding protein 0.0065 0.0599 0.0599
Trichomonas vaginalis D-aminoacylase, putative 0.0106 0.1101 0.3159
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0224 0.0224
Brugia malayi Calcitonin receptor-like protein seb-1 0.0109 0.1131 0.324
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.0267 0.0267
Loa Loa (eye worm) hypothetical protein 0.0085 0.0848 0.2217
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0105 0.0812
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0056 0.0494 0.0494
Giardia lamblia Fructose-bisphosphate aldolase 0.0285 0.329 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0267 0.2312
Onchocerca volvulus 0.0053 0.0453 0.123
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0055 0.0055
Trichomonas vaginalis penicillin-binding protein, putative 0.0106 0.1101 0.3159
Loa Loa (eye worm) hypothetical protein 0.0034 0.0224 0.0551
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.0267 0.1926
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0034 0.0225 0.0225
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.329 0.9908
Echinococcus granulosus lamin 0.0033 0.0202 0.0202
Loa Loa (eye worm) hypothetical protein 0.0106 0.1101 0.289
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0083 0.0816 0.0816
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.023 0.023
Schistosoma mansoni P2X receptor subunit 0.0686 0.8199 0.8199
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0037 0.026 0.026
Loa Loa (eye worm) hypothetical protein 0.0032 0.0195 0.0474
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0077 0.0555
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0184 0.2057 0.5931
Schistosoma mansoni hypothetical protein 0.0164 0.1813 0.1813
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.1567 0.4133
Mycobacterium leprae Probable lipase LipE 0.0106 0.1101 0.7279
Trypanosoma cruzi PAB1-binding protein , putative 0.0077 0.0744 0.6704
Echinococcus multilocularis snurportin 1 0.0324 0.3769 0.3769
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0267 0.0588
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0058 0.0512 0.0512
Brugia malayi follicle stimulating hormone receptor 0.0226 0.2574 0.7434
Onchocerca volvulus 0.0033 0.0202 0.0462
Brugia malayi MH2 domain containing protein 0.0144 0.1567 0.4508
Schistosoma mansoni hypothetical protein 0.0301 0.3491 0.3491
Loa Loa (eye worm) subtilase 0.0265 0.3051 0.8088
Giardia lamblia Histone acetyltransferase GCN5 0.008 0.0779 0.2185
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0267 0.2312
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0139 0.1506 1
Trypanosoma brucei cytochrome P450, putative 0.0026 0.0123 0.0978
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.329 0.9908
Loa Loa (eye worm) hypothetical protein 0.0033 0.0202 0.0494
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0184 0.2057 0.5438
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0106 0.1101 0.1101
Echinococcus granulosus GPCR family 2 0.0034 0.0224 0.0224
Schistosoma mansoni hypothetical protein 0.0074 0.0711 0.0711
Mycobacterium ulcerans beta-lactamase 0.0106 0.1101 0.7279
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0105 0.0086
Schistosoma mansoni cpg binding protein 0.0059 0.0529 0.0529
Schistosoma mansoni hypothetical protein 0.0035 0.023 0.023
Echinococcus granulosus histone acetyltransferase KAT2B 0.0287 0.332 0.332
Schistosoma mansoni polycystin 1-related 0.002 0.0051 0.0051
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0224 0.0224
Onchocerca volvulus 0.0037 0.026 0.064
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0053 0.0453 0.1269
Schistosoma mansoni hypothetical protein 0.0034 0.0224 0.0224
Brugia malayi mbt repeat family protein 0.005 0.041 0.1144
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.002 0.0044 0.0044
Entamoeba histolytica hypothetical protein 0.0035 0.023 0.0477
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0077 0.0354
Leishmania major importin beta-1 subunit, putative 0.0025 0.0105 0.0812
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0175 0.1215
Brugia malayi Inositol-1 0.0038 0.0267 0.0729
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0175 0.1459
Trypanosoma cruzi hypothetical protein, conserved 0.0106 0.1101 1
Mycobacterium leprae conserved hypothetical protein 0.0106 0.1101 0.7279
Echinococcus granulosus histone lysine methyltransferase setb 0.0058 0.0512 0.0512
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0202 0.0494
Echinococcus granulosus intermediate filament protein 0.0033 0.0202 0.0202
Schistosoma mansoni zinc finger protein 0.0034 0.0223 0.0223
Echinococcus multilocularis lamin dm0 0.0033 0.0202 0.0202
Brugia malayi F/Y-rich N-terminus family protein 0.0022 0.007 0.0154
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.005 0.041 0.041
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0034 0.0225 0.0225
Echinococcus granulosus geminin 0.0164 0.1813 0.1813
Schistosoma mansoni P2X receptor subunit 0.0686 0.8199 0.8199
Schistosoma mansoni microtubule-associated protein tau 0.0833 1 1
Echinococcus granulosus p2X purinoceptor 4 0.0686 0.8199 0.8199
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0224 0.0551
Brugia malayi CXXC zinc finger family protein 0.0059 0.0529 0.1491
Echinococcus granulosus dnaJ subfamily B 0.042 0.4941 0.4941
Echinococcus granulosus p2X purinoceptor 4 0.0686 0.8199 0.8199
Loa Loa (eye worm) hypothetical protein 0.0106 0.1101 0.289
Entamoeba histolytica hypothetical protein 0.0035 0.023 0.0477
Schistosoma mansoni loxhd1 0.002 0.0051 0.0051
Entamoeba histolytica hypothetical protein 0.0035 0.023 0.0477
Plasmodium vivax histone acetyltransferase GCN5, putative 0.009 0.0902 0.8109
Echinococcus granulosus importin subunit beta 1 0.003 0.0175 0.0175
Loa Loa (eye worm) bromodomain containing protein 0.0029 0.0153 0.0364
Echinococcus multilocularis RUN 0.002 0.0051 0.0051
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.026 0.026
Mycobacterium tuberculosis Probable esterase LipL 0.0106 0.1101 0.1343
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.329 0.9908
Echinococcus multilocularis p2X purinoceptor 4 0.0686 0.8199 0.8199
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0253 0.2894 0.767
Schistosoma mansoni ran 0.0022 0.0077 0.0077
Brugia malayi Pre-SET motif family protein 0.0253 0.2894 0.8366
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.329 0.9908
Loa Loa (eye worm) acetyltransferase 0.0299 0.3457 0.9169
Echinococcus multilocularis p2X purinoceptor 4 0.0686 0.8199 0.8199
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.329 0.9908
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0017 0.0001
Echinococcus granulosus cpg binding protein 0.0065 0.0599 0.0599
Entamoeba histolytica hypothetical protein 0.0025 0.0105 0.0087
Echinococcus granulosus histone acetyltransferase MYST2 0.0056 0.0494 0.0494
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.023 0.023
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0224 0.0224
Echinococcus granulosus polycomb protein SCMH1 0.005 0.041 0.041
Trypanosoma cruzi PAB1-binding protein , putative 0.0077 0.0744 0.6704
Schistosoma mansoni zinc finger protein 0.0018 0.0029 0.0029
Leishmania major hypothetical protein, conserved 0.0077 0.0744 0.6704
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0123 0.0283
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0109 0.1131 0.297
Brugia malayi Bromodomain containing protein 0.0101 0.1042 0.298
Schistosoma mansoni sex comb on midleg homolog 0.005 0.041 0.041
Loa Loa (eye worm) hypothetical protein 0.002 0.0051 0.0092
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0077 0.016
Trichomonas vaginalis D-aminoacylase, putative 0.0106 0.1101 0.3159
Onchocerca volvulus 0.0106 0.1101 0.3213
Entamoeba histolytica hypothetical protein 0.0035 0.023 0.0477
Onchocerca volvulus 0.0106 0.1101 0.3213
Trypanosoma cruzi cytochrome P450, putative 0.0026 0.0123 0.0978
Mycobacterium tuberculosis Probable hydrolase 0.0106 0.1101 0.1343
Trichomonas vaginalis penicillin-binding protein, putative 0.0106 0.1101 0.3159
Brugia malayi Doublecortin family protein 0.002 0.0051 0.01
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0037 0.026 0.026
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0051 0.0051
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0106 0.1101 0.1343
Echinococcus granulosus beta LACTamase domain containing family member 0.0106 0.1101 0.1101
Schistosoma mansoni rab6-interacting 0.002 0.0051 0.0051
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0123 0.0283
Loa Loa (eye worm) mbt repeat family protein 0.005 0.041 0.1049
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0051 0.0051
Trichomonas vaginalis set domain proteins, putative 0.0287 0.3319 1
Mycobacterium ulcerans hypothetical protein 0.0106 0.1101 0.7279
Mycobacterium tuberculosis Conserved protein 0.0106 0.1101 0.1343
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0043 0.0334 0.0334
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0184 0.2057 0.2057
Echinococcus granulosus RUN 0.002 0.0051 0.0051
Plasmodium falciparum histone acetyltransferase GCN5 0.008 0.0779 1
Brugia malayi hypothetical protein 0.0077 0.0744 0.2113
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0031 0.0178 0.0178
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.329 0.9908
Schistosoma mansoni hypothetical protein 0.002 0.0051 0.0051
Schistosoma mansoni hypothetical protein 0.0034 0.0224 0.0224
Trypanosoma brucei PAB1-binding protein , putative 0.0077 0.0744 0.6704
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.002 0.0044 0.0044
Onchocerca volvulus 0.0106 0.1101 0.3213
Brugia malayi Cytochrome P450 family protein 0.0026 0.0123 0.0308
Mycobacterium ulcerans esterase/lipase LipP 0.0106 0.1101 0.7279
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0106 0.1101 0.289
Schistosoma mansoni inositol monophosphatase 0.0038 0.0267 0.0267
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0184 0.2057 0.2057
Echinococcus multilocularis histone acetyltransferase MYST2 0.0056 0.0494 0.0494
Loa Loa (eye worm) inositol-1 0.0038 0.0267 0.0668
Schistosoma mansoni P2X receptor subunit 0.0686 0.8199 0.8199
Loa Loa (eye worm) hypothetical protein 0.0046 0.037 0.0943
Echinococcus multilocularis 0.0017 0.0017 0.0017
Brugia malayi mbt repeat family protein 0.005 0.041 0.1144
Schistosoma mansoni hypothetical protein 0.0324 0.3769 0.3769
Brugia malayi hypothetical protein 0.0035 0.023 0.062
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0105 0.0086
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0184 0.2057 0.2057
Schistosoma mansoni lipoxygenase 0.0121 0.1285 0.1285
Mycobacterium ulcerans lipase LipD 0.0106 0.1101 0.7279
Echinococcus multilocularis GPCR, family 2 0.0034 0.0224 0.0224
Schistosoma mansoni lipoxygenase 0.0085 0.0839 0.0839
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.329 0.9908
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.023 0.023
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0077 0.0555
Toxoplasma gondii LsmAD domain-containing protein 0.0077 0.0744 0.5583
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0051 0.0051
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0053 0.0453 0.0453
Schistosoma mansoni bromodomain containing protein 0.0087 0.0868 0.0868
Echinococcus multilocularis dnaJ subfamily B 0.042 0.4941 0.4941
Schistosoma mansoni hypothetical protein 0.0018 0.0029 0.0029
Schistosoma mansoni lamin 0.0033 0.0202 0.0202
Treponema pallidum fructose-bisphosphate aldolase 0.0285 0.329 0.5
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0077 0.0175
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0106 0.1101 0.7279
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0083 0.0816 0.0816
Echinococcus granulosus inhibitor of apoptosis protein 0.0053 0.0453 0.0453
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0224 0.0601
Leishmania major hypothetical protein, conserved 0.0018 0.0029 0.0119
Echinococcus granulosus histone acetyltransferase KAT2B 0.009 0.0902 0.0902
Toxoplasma gondii histone lysine methyltransferase SET1 0.0124 0.1319 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.0355 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 2.2387 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 5.0119 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 7.0795 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 7.9433 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 79.4328 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.