Detailed information for compound 1425735

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 313.356 | Formula: C19H15N5
  • H donors: 1 H acceptors: 4 LogP: 3.09 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc2c(c1)C(=NNC(=N2)c1cccnc1)c1ccncc1
  • InChi: 1S/C19H15N5/c1-13-4-5-17-16(11-13)18(14-6-9-20-10-7-14)23-24-19(22-17)15-3-2-8-21-12-15/h2-12H,1H3,(H,22,24)
  • InChiKey: GWKFYRACXBSRHQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Peptidase family M13 containing protein 0.0413 0.2379 0.2814
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0104 0.0539 0.2108
Giardia lamblia DINP protein human, muc B family 0.0042 0.0174 0.0947
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0096 0.2702
Brugia malayi Pre-SET motif family protein 0.0227 0.1269 0.1501
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0329 0.0645
Mycobacterium tuberculosis Probable zinc metalloprotease Zmp1 0.0413 0.2379 0.4966
Wolbachia endosymbiont of Brugia malayi phosphatase 0.0021 0.0047 0.8182
Mycobacterium tuberculosis Possible peroxidase BpoB (non-haem peroxidase) 0.0022 0.0055 0.0103
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.0153 0.4323
Schistosoma mansoni aminopeptidase A (M01 family) 0.0026 0.0076 0.0148
Onchocerca volvulus Phospholipase A2 homolog 0.029 0.1644 0.3876
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0153 0.6235
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.0174 0.4913
Loa Loa (eye worm) hypothetical protein 0.012 0.0636 0.0753
Trypanosoma cruzi DNA polymerase eta, putative 0.0042 0.0174 0.4913
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0.0057 0.0051
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0115 0.0136
Brugia malayi Nuclear hormone receptor-like 1 0.0019 0.0034 0.0041
Trypanosoma brucei hydrolase, alpha/beta fold family, putative 0.0022 0.0055 0.1553
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0153 0.0814
Echinococcus multilocularis lysosomal acid lipase:cholesteryl ester 0.0022 0.0055 0.0049
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0153 0.4323
Echinococcus granulosus dnaJ subfamily B 0.0871 0.5102 0.7599
Leishmania major serine peptidase, putative,serine peptidase, Clan SC, Family S9D 0.0022 0.0055 0.1553
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0014 0.0006 0.0242
Trypanosoma brucei aminopeptidase, putative 0.0026 0.0076 0.2129
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.0006 0.0168
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0049 0.0211 0.0205
Schistosoma mansoni hypothetical protein 0.0871 0.5102 1
Mycobacterium leprae Possible short-chain dehydrogenase EphD 0.003 0.01 0.0224
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0047 0.0087
Loa Loa (eye worm) hypothetical protein 0.0088 0.0443 0.0524
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0103 0.0532 0.0527
Plasmodium vivax glutathione reductase, putative 0.0041 0.0165 0.6712
Mycobacterium tuberculosis Probable hydrolase 0.0039 0.0153 0.0308
Loa Loa (eye worm) hypothetical protein 0.029 0.1644 0.1945
Echinococcus granulosus abhydrolase domain containing protein 3 0.0022 0.0055 0.0073
Mycobacterium ulcerans lignin peroxidase LipJ 0.0022 0.0055 0.0115
Onchocerca volvulus 0.0033 0.0115 0.0245
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0019 0.0034 0.0041
Mycobacterium ulcerans fatty-acid-CoA ligase 0.002 0.0038 0.0079
Toxoplasma gondii aminopeptidase n, putative 0.0026 0.0076 0.0317
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0021 0.0047 0.0237
Loa Loa (eye worm) hypothetical protein 0.0346 0.1977 0.2338
Schistosoma mansoni intermediate filament proteins 0.0033 0.0115 0.0226
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0021 0.0047 0.0237
Echinococcus multilocularis integrin alpha ps 0.0034 0.0125 0.0119
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.0006 0.0168
Brugia malayi steroid hormone receptor 0.0019 0.0034 0.0041
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0022 0.0055 0.0278
Trypanosoma brucei hydrolase, alpha/beta fold family, putative 0.0022 0.0055 0.1553
Echinococcus granulosus intermediate filament protein 0.0033 0.0115 0.0163
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0077 0.0161
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0021 0.0047 0.0237
Leishmania major hydrolase, alpha/beta fold family, putative 0.0022 0.0055 0.1553
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0413 0.2379 0.4663
Echinococcus granulosus histone deacetylase 3 0.0043 0.0174 0.0251
Mycobacterium ulcerans esterase/lipase LipP 0.0039 0.0153 0.032
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.0034 0.0042
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0322 0.1839 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0034 0.0041
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0019 0.0034 0.0041
Onchocerca volvulus 0.0133 0.071 0.1658
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0122 0.0238
Mycobacterium ulcerans aminopeptidase N PepN 0.0026 0.0076 0.0158
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0049 0.0211 0.0305
Loa Loa (eye worm) hypothetical protein 0.0039 0.0153 0.0181
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0329 0.0645
Trypanosoma cruzi PAB1-binding protein , putative 0.0055 0.0246 0.6933
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0026 0.0076 0.2129
Plasmodium falciparum glutathione reductase 0.0041 0.0165 0.6712
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0019 0.0034 0.0067
Schistosoma mansoni hypothetical protein 0.0072 0.0353 0.0691
Mycobacterium ulcerans hydrolase 0.0022 0.0055 0.0115
Brugia malayi hypothetical protein 0.0049 0.0211 0.0249
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0021 0.0047 0.0237
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0014 0.0006 0.0025
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0057 0.1597
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0026 0.0076 0.3071
Loa Loa (eye worm) hypothetical protein 0.0019 0.0034 0.0041
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0049 0.0211 0.0305
Schistosoma mansoni family M1 non-peptidase homologue (M01 family) 0.0023 0.0057 0.0111
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0047 0.0237
Echinococcus granulosus muscleblind protein 0.0491 0.2841 0.4227
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0021 0.0047 0.0237
Plasmodium falciparum acyl-CoA synthetase 0.002 0.0038 0.1538
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0034 0.0067
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0014 0.0006 0.0168
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0122 0.0116
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0026 0.0077 0.0149
Schistosoma mansoni hypothetical protein 0.0072 0.0353 0.0691
Trypanosoma cruzi hydrolase, alpha/beta fold family, putative 0.0022 0.0055 0.1553
Plasmodium falciparum alpha/beta hydrolase, putative 0.0022 0.0055 0.2241
Loa Loa (eye worm) hypothetical protein 0.0023 0.0057 0.0067
Echinococcus multilocularis endothelin converting enzyme 1 0.0413 0.2379 0.2375
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.016 0.0873 0.0867
Toxoplasma gondii NADPH-glutathione reductase 0.0014 0.0006 0.0025
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0021 0.0047 0.0237
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0042 0.0174 0.0251
Entamoeba histolytica alpha/beta hydrolase fold protein, putative 0.0022 0.0055 0.0043
Schistosoma mansoni terminal deoxycytidyl transferase 0.0042 0.0174 0.0341
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0047 0.0201 0.1075
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0047 0.0201 0.0846
Schistosoma mansoni hydrolase 0.0022 0.0055 0.0108
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0174 0.4913
Echinococcus granulosus cpg binding protein 0.0065 0.0306 0.0448
Mycobacterium tuberculosis Probable exported protease 0.0022 0.0055 0.0103
Onchocerca volvulus Bile acid receptor homolog 0.0019 0.0034 0.0053
Echinococcus multilocularis cpg binding protein 0.0065 0.0306 0.03
Schistosoma mansoni ephrin receptor 0.007 0.0339 0.0665
Onchocerca volvulus Epoxide hydrolase 1 homolog 0.0022 0.0055 0.0103
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0107 0.0559 0.0661
Leishmania major histone deacetylase, putative 0.0043 0.0174 0.4918
Schistosoma mansoni family S33 non-peptidase homologue (S33 family) 0.0022 0.0055 0.0108
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.002 0.0041 0.0053
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0143 0.0774 0.1516
Loa Loa (eye worm) TAR-binding protein 0.0069 0.0329 0.0389
Echinococcus multilocularis thyroid hormone receptor alpha 0.0019 0.0034 0.0028
Loa Loa (eye worm) TK/EPH protein kinase 0.0089 0.0453 0.0535
Schistosoma mansoni retinoic acid receptor RXR 0.0019 0.0034 0.0067
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0042 0.0174 0.4913
Plasmodium vivax hypothetical protein, conserved 0.0022 0.0055 0.2241
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0021 0.0047 0.0237
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0019 0.0034 0.0041
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0103 0.0532 0.063
Brugia malayi glutathione reductase 0.0041 0.0165 0.0195
Loa Loa (eye worm) HAD-superfamily hydrolase 0.0021 0.0047 0.0056
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.0057 0.0308
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.014 0.0755 0.1479
Loa Loa (eye worm) hypothetical protein 0.0413 0.2379 0.2814
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0014 0.0006 0.0242
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0174 0.4913
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0158 0.0858 0.1784
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0019 0.0034 0.0041
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0158 0.0858 0.3477
Trichomonas vaginalis mercuric reductase, putative 0.0014 0.0006 0.0011
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.0153 0.0147
Echinococcus granulosus geminin 0.0537 0.3116 0.4637
Onchocerca volvulus 0.0039 0.0153 0.0336
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.0174 0.4913
Echinococcus granulosus lamin dm0 0.0033 0.0115 0.0163
Loa Loa (eye worm) zinc metallopeptidase 4 0.0068 0.0324 0.0383
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0021 0.0047 0.0237
Schistosoma mansoni hypothetical protein 0.0072 0.0353 0.0691
Schistosoma mansoni Nep2 peptidase (M13 family) 0.014 0.0755 0.1479
Echinococcus multilocularis dna polymerase eta 0.0042 0.0174 0.0168
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0103 0.0532 0.1044
Plasmodium falciparum histone deacetylase 1 0.0043 0.0174 0.7093
Loa Loa (eye worm) hypothetical protein 0.0019 0.0034 0.0041
Mycobacterium leprae conserved hypothetical protein 0.0039 0.0153 0.0454
Trypanosoma cruzi PAB1-binding protein , putative 0.0055 0.0246 0.6933
Echinococcus granulosus thioredoxin glutathione reductase 0.0041 0.0168 0.0242
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0103 0.0532 0.0527
Echinococcus multilocularis FTZ F1 alpha 0.0019 0.0034 0.0028
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0019 0.0034 0.0028
Loa Loa (eye worm) hypothetical protein 0.0341 0.1948 0.2304
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.014 0.0755 0.1479
Schistosoma mansoni hypothetical protein 0.0072 0.0353 0.0691
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0322 0.1839 1
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0014 0.0006 0.0168
Onchocerca volvulus 0.0258 0.1454 0.3424
Leishmania major hydrolase-like protein,esterase-like protein 0.0022 0.0055 0.1553
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0096 0.2702
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0057 0.2303
Echinococcus multilocularis tar DNA binding protein 0.0069 0.0329 0.0324
Loa Loa (eye worm) hypothetical protein 0.0037 0.0142 0.0168
Schistosoma mansoni ap endonuclease 0.0023 0.0057 0.0111
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0069 0.0329 0.0389
Schistosoma mansoni ap endonuclease 0.0023 0.0057 0.0111
Schistosoma mansoni hypothetical protein 0.0034 0.0123 0.0242
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0021 0.0047 0.0237
Mycobacterium tuberculosis Conserved protein 0.0039 0.0153 0.0308
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0014 0.0006 0.0168
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.0057 1
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0042 0.0174 0.0352
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.0006 0.0168
Echinococcus multilocularis ephrin type A receptor 4 A 0.007 0.0339 0.0334
Giardia lamblia Hydrolase, putative 0.0021 0.0047 0.0258
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0026 0.0076 0.039
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.0057 0.0277
Trypanosoma brucei histone deacetylase 1 0.0043 0.0174 0.4918
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0143 0.0774 0.0915
Loa Loa (eye worm) hypothetical protein 0.0033 0.0115 0.0136
Echinococcus multilocularis dnaJ subfamily B 0.0871 0.5102 0.51
Echinococcus granulosus lamin 0.0033 0.0115 0.0163
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0153 0.0814
Mycobacterium tuberculosis Probable homoserine O-acetyltransferase MetA (homoserine O-trans-acetylase) (homoserine transacetylase) (HTA) 0.0022 0.0055 0.0103
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0014 0.0006 0.0168
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0123 0.0146
Schistosoma mansoni choline dehydrogenase 0.0021 0.0047 0.0093
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0047 0.0201 0.8183
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.0034 0.0028
Schistosoma mansoni hypothetical protein 0.0537 0.3116 0.6106
Brugia malayi HAD-superfamily hydrolase, subfamily IA, variant 1 containing protein 0.0021 0.0047 0.0056
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0073 0.0355 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0019 0.0034 0.0067
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.0077 0.0149
Mycobacterium ulcerans lipase/esterase 0.0022 0.0055 0.0115
Loa Loa (eye worm) hypothetical protein 0.002 0.0038 0.0045
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0031 0.0053
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0057 0.0067
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0047 0.0237
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0019 0.0034 0.0041
Trypanosoma cruzi histone deacetylase 1, putative 0.0043 0.0174 0.4918
Entamoeba histolytica deoxycytidyl transferase, putative 0.0042 0.0174 0.0708
Plasmodium vivax acyl-CoA synthetase, putative 0.002 0.0038 0.1538
Plasmodium falciparum ataxin-2 like protein, putative 0.0055 0.0246 1
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0026 0.0076 0.0104
Trypanosoma cruzi glycosyl hydrolase, putative 0.0021 0.0047 0.1337
Loa Loa (eye worm) hypothetical protein 0.0084 0.0421 0.0498
Onchocerca volvulus 0.0026 0.0077 0.0155
Trypanosoma cruzi trypanothione reductase, putative 0.0014 0.0006 0.0168
Mycobacterium ulcerans haloalkane dehalogenase 0.0022 0.0055 0.0115
Onchocerca volvulus 0.0049 0.0211 0.0472
Mycobacterium ulcerans DNA polymerase IV 0.0042 0.0174 0.0364
Loa Loa (eye worm) steroid hormone receptor 0.0019 0.0034 0.0041
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0022 0.0055 0.0278
Loa Loa (eye worm) hypothetical protein 0.0413 0.2379 0.2814
Giardia lamblia ENC6 protein 0.0022 0.0055 0.03
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0024 0.0067 0.0061
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0049 0.0211 0.0205
Loa Loa (eye worm) hypothetical protein 0.0019 0.0034 0.0041
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0019 0.0034 0.0067
Mycobacterium ulcerans epoxide hydrolase EphA 0.0818 0.4785 1
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0021 0.0047 0.0237
Mycobacterium ulcerans hypothetical protein 0.0022 0.0055 0.0115
Brugia malayi histone deacetylase 1 (HD1) 0.0043 0.0174 0.0206
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0014 0.0006 0.0012
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0322 0.1839 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0153 0.0181
Mycobacterium ulcerans exported protease 0.0022 0.0055 0.0115
Brugia malayi alpha/beta hydrolase 0.0022 0.0055 0.0065
Brugia malayi Alpha/beta hydrolase 0.0022 0.0055 0.0065
Brugia malayi Angiotensin-converting enzyme family protein 0.1435 0.8456 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0019 0.0034 0.0053
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0123 0.0146
Schistosoma mansoni cpg binding protein 0.0065 0.0306 0.06
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0122 0.0238
Echinococcus granulosus haloacid dehalogenase hydrolase 0.0021 0.0047 0.0062
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0019 0.0034 0.0041
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0158 0.0858 0.1794
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0077 0.0166
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0153 0.0814
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.002 0.0038 0.7681
Entamoeba histolytica aminopeptidase, putative 0.0049 0.0211 0.0911
Loa Loa (eye worm) beta-lactamase 0.0039 0.0153 0.0181
Schistosoma mansoni hypothetical protein 0.0072 0.0353 0.0691
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0174 0.4913
Loa Loa (eye worm) hypothetical protein 0.0019 0.0034 0.0041
Schistosoma mansoni thyroid hormone receptor 0.0019 0.0034 0.0067
Echinococcus granulosus dna polymerase eta 0.0042 0.0174 0.0251
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0103 0.0532 0.1044
Giardia lamblia Histone acetyltransferase GCN5 0.0043 0.0178 0.0967
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0026 0.0076 0.2129
Echinococcus granulosus endothelin converting enzyme 1 0.0413 0.2379 0.3539
Mycobacterium tuberculosis Possible epoxide hydrolase EphF (epoxide hydratase) (arene-oxide hydratase) 0.0022 0.0055 0.0103
Mycobacterium tuberculosis Probable carboxylesterase CaeA 0.0022 0.0055 0.0103
Echinococcus granulosus leukotriene A 4 hydrolase 0.0143 0.0774 0.1145
Brugia malayi TAR-binding protein 0.0069 0.0329 0.0389
Onchocerca volvulus 0.0026 0.0076 0.0151
Echinococcus multilocularis muscleblind protein 1 0.0491 0.2841 0.2837
Loa Loa (eye worm) hypothetical protein 0.0723 0.4224 0.4995
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0014 0.0006 0.0168
Schistosoma mansoni neprilysin-2 (M13 family) 0.014 0.0755 0.1479
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0047 0.0237
Loa Loa (eye worm) MH2 domain-containing protein 0.0129 0.0686 0.0811
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0073 0.0355 0.052
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0039 0.0153 0.0308
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0107 0.0559 0.0661
Loa Loa (eye worm) hypothetical protein 0.0346 0.1977 0.2338
Brugia malayi beta-lactamase 0.0039 0.0153 0.0181
Loa Loa (eye worm) HAD-superfamily hydrolase 0.0021 0.0047 0.0056
Brugia malayi hydrolase, alpha/beta fold family protein 0.0022 0.0055 0.0065
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0093 0.0477 0.1842
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0026 0.0076 0.0104
Schistosoma mansoni cpg binding protein 0.0065 0.0306 0.06
Trypanosoma brucei DNA polymerase eta, putative 0.0042 0.0174 0.4913
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0019 0.0034 0.0067
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0174 0.4913
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0043 0.0174 0.0929
Loa Loa (eye worm) hypothetical protein 0.0341 0.1948 0.2304
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0049 0.0211 0.5938
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0057 0.2303
Schistosoma mansoni endothelin-converting enzyme-related 0.0068 0.0324 0.0635
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0103 0.0532 0.0785
Toxoplasma gondii histone deacetylase HDAC3 0.0043 0.0174 0.0733
Echinococcus granulosus tar DNA binding protein 0.0069 0.0329 0.0482
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0026 0.0077 0.0161
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.0153 0.0181
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0174 0.4913
Schistosoma mansoni integrin alpha-ps 0.0071 0.0345 0.0677
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0019 0.0034 0.0041
Giardia lamblia Histone deacetylase 0.0043 0.0174 0.0948
Brugia malayi haloacid dehalogenase-like hydrolase family protein 0.0021 0.0047 0.0056
Trypanosoma cruzi aminopeptidase, putative 0.0049 0.0211 0.5938
Trichomonas vaginalis set domain proteins, putative 0.0258 0.1454 0.7902
Brugia malayi nuclear receptor NHR-88 0.0019 0.0034 0.0041
Loa Loa (eye worm) hypothetical protein 0.0341 0.1948 0.2304
Brugia malayi Integrin alpha pat-2 precursor 0.0159 0.0867 0.1025
Brugia malayi ecdysteroid receptor 0.0019 0.0034 0.0041
Giardia lamblia Fructose-bisphosphate aldolase 0.0322 0.1839 1
Trichomonas vaginalis histone deacetylase, putative 0.0043 0.0174 0.0929
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.004 0.0047
Echinococcus multilocularis geminin 0.0537 0.3116 0.3112
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0057 0.0076
Trypanosoma brucei unspecified product 0.0029 0.0096 0.2702
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0019 0.0034 0.0041
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0077 0.0091
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0043 0.0174 0.0929
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0104 0.0539 0.1115
Loa Loa (eye worm) hypothetical protein 0.0491 0.2841 0.336
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0031 0.0053
Mycobacterium tuberculosis Conserved protein 0.0039 0.0153 0.0308
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0039 0.0153 0.032
Loa Loa (eye worm) hypothetical protein 0.002 0.0038 0.0045
Brugia malayi Thioredoxin reductase 0.0041 0.0165 0.0195
Brugia malayi ImpB/MucB/SamB family protein 0.0042 0.0174 0.0206
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0055 0.1553
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0014 0.0006 0.0168
Brugia malayi Calcitonin receptor-like protein seb-1 0.0107 0.0559 0.0661
Mycobacterium leprae POSSIBLE EPOXIDE HYDROLASE EPHE (EPOXIDE HYDRATASE) (ARENE-OXIDE HYDRATASE) 0.0022 0.0055 0.0033
Mycobacterium tuberculosis Probable dehydrogenase 0.0093 0.0477 0.0986
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.1435 0.8456 1
Mycobacterium tuberculosis Probable esterase LipL 0.0039 0.0153 0.0308
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0322 0.1839 1
Brugia malayi haloacid dehalogenase-like hydrolase family protein 0.0021 0.0047 0.0056
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0026 0.0076 0.2129
Echinococcus granulosus integrin alpha ps 0.0034 0.0125 0.0177
Schistosoma mansoni integrin alpha 0.0159 0.0867 0.1698
Plasmodium vivax hypothetical protein, conserved 0.0022 0.0055 0.2241
Trichomonas vaginalis DNA polymerase eta, putative 0.0042 0.0174 0.0928
Entamoeba histolytica histone deacetylase, putative 0.0043 0.0174 0.0709
Schistosoma mansoni hypothetical protein 0.0537 0.3116 0.6106
Trichomonas vaginalis bromodomain-containing protein, putative 0.0047 0.0201 0.1075
Mycobacterium tuberculosis Probable lipase LipE 0.0039 0.0153 0.0308
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0049 0.0211 0.0205
Brugia malayi peptidase family M13 containing protein 0.0068 0.0324 0.0383
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0057 0.0287
Brugia malayi ImpB/MucB/SamB family protein 0.0042 0.0174 0.0206
Chlamydia trachomatis phosphoglycolate phosphatase 0.0021 0.0047 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0123 0.0175
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0021 0.0047 0.0237
Mycobacterium ulcerans hydrolase 0.0021 0.0047 0.0099
Schistosoma mansoni hypothetical protein 0.0034 0.0123 0.0242
Loa Loa (eye worm) hypothetical protein 0.0019 0.0034 0.0041
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0016 0.0019 0.0013
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0041 0.0165 0.0333
Loa Loa (eye worm) peptidase family M13 containing protein 0.0341 0.1948 0.2304
Mycobacterium leprae Probable exported protease 0.0022 0.0055 0.0033
Loa Loa (eye worm) hypothetical protein 0.0413 0.2379 0.2814
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0123 0.0117
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0026 0.0076 0.2129
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0049 0.0211 0.0305
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0022 0.0055 0.0278
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0026 0.0076 0.3071
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0093 0.0477 0.0986
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0131 0.07 0.1372
Mycobacterium tuberculosis Probable oxidoreductase 0.0104 0.0539 0.1115
Echinococcus multilocularis aminopeptidase N 0.0133 0.071 0.0705
Brugia malayi Steroid receptor seven-up type 2 0.0019 0.0034 0.0041
Loa Loa (eye worm) hypothetical protein 0.0035 0.0132 0.0156
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0249 0.1402 0.2921
Mycobacterium ulcerans epoxide hydrolase EphE 0.0022 0.0055 0.0115
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0031 0.0053
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0023 0.0057 0.1598
Trypanosoma cruzi hydrolase-like protein, putative 0.0022 0.0055 0.1553
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0019 0.0034 0.0067
Schistosoma mansoni 2-deoxyglucose-6-phosphate phosphatase 0.0021 0.0047 0.0093
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0039 0.0153 0.0308
Loa Loa (eye worm) hydrolase 0.0022 0.0055 0.0065
Schistosoma mansoni hypothetical protein 0.0036 0.0138 0.0271
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0016 0.0019 0.0013
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0042 0.0174 0.0168
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.0006 0.0168
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0049 0.0211 0.5938
Toxoplasma gondii exonuclease III APE 0.0023 0.0057 0.0238
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0023 0.0057 0.0051
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0049 0.0211 0.1126
Onchocerca volvulus Lipase homolog 0.0022 0.0055 0.0103
Mycobacterium ulcerans exported protease 0.0022 0.0055 0.0115
Mycobacterium leprae Probable exported protease 0.0022 0.0055 0.0033
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0057 0.1597
Mycobacterium ulcerans hypothetical protein 0.0021 0.0047 0.0099
Mycobacterium leprae POSSIBLE SECRETED PROTEASE 0.0022 0.0055 0.0033
Loa Loa (eye worm) hypothetical protein 0.002 0.0038 0.0045
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.0057 0.0118
Loa Loa (eye worm) hypothetical protein 0.002 0.0038 0.0045
Schistosoma mansoni integrin alpha-ps 0.0037 0.0142 0.0279
Treponema pallidum phosphoglycolate phosphatase 0.0021 0.0047 0.0226
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0174 0.4913
Echinococcus granulosus dna polymerase kappa 0.0042 0.0174 0.0251
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0153 0.4323
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0019 0.0034 0.0041
Mycobacterium leprae Probable lipase LipE 0.0039 0.0153 0.0454
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0021 0.0047 0.0237
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0138 0.0133
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0016 0.0015 0.0014
Echinococcus multilocularis lysosomal acid lipase:cholesteryl ester 0.0022 0.0055 0.0049
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0153 0.0814
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0104 0.0539 0.1115
Brugia malayi Peptidase family M1 containing protein 0.0049 0.0211 0.0249
Echinococcus multilocularis abhydrolase domain containing protein 0.0022 0.0055 0.0049
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0014 0.0006 0.0242
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0057 0.1597
Echinococcus multilocularis abhydrolase domain containing protein 11 0.0022 0.0055 0.0049
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0073 0.0355 0.0419
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0014 0.0006 0.0007
Mycobacterium ulcerans bromoperoxidase BpoC 0.0022 0.0055 0.0115
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0014 0.0006 0.0012
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0026 0.0077 0.0161
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0049 0.0211 0.0205
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0021 0.0047 0.0237
Schistosoma mansoni histone deacetylase 0.0043 0.0174 0.0342
Mycobacterium tuberculosis Probable haloalkane dehalogenase 0.0022 0.0055 0.0103
Loa Loa (eye worm) hypothetical protein 0.0491 0.2841 0.336
Schistosoma mansoni coup transcription factor 0.0019 0.0034 0.0067
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0019 0.0034 0.0041
Loa Loa (eye worm) hypothetical protein 0.0346 0.1977 0.2338
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0153 0.03
Mycobacterium ulcerans hypothetical protein 0.0022 0.0055 0.0115
Onchocerca volvulus 0.0021 0.0047 0.0084
Toxoplasma gondii alpha/beta hydrolase, putative 0.0022 0.0055 0.0232
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0174 0.4913
Trichomonas vaginalis histone deacetylase, putative 0.0043 0.0174 0.0929
Trichomonas vaginalis esterase, putative 0.0039 0.0153 0.0814
Onchocerca volvulus 0.0019 0.0034 0.0053
Echinococcus multilocularis integrin alpha ps 0.0071 0.0345 0.0339
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0068 0.0324 0.0635
Leishmania major DNA polymerase eta, putative 0.0042 0.0174 0.4913
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0138 0.0271
Entamoeba histolytica hypothetical protein 0.0022 0.0055 0.0043
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0153 0.03
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0174 0.4913
Giardia lamblia Phosphoglycolate phosphatase 0.0021 0.0047 0.0258
Trypanosoma cruzi Aminopeptidase M1, putative 0.0049 0.0211 0.5938
Mycobacterium ulcerans beta-lactamase 0.0039 0.0153 0.032
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0019 0.0034 0.0041
Leishmania major hypothetical protein, conserved 0.0022 0.0055 0.1553
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0115 0.0136
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0057 0.0287
Mycobacterium ulcerans homoserine O-acetyltransferase 0.0022 0.0055 0.0115
Brugia malayi Pre-SET motif family protein 0.0034 0.0122 0.0144
Mycobacterium ulcerans hydrolase 0.0022 0.0055 0.0115
Loa Loa (eye worm) HAD-superfamily hydrolase 0.0021 0.0047 0.0056
Onchocerca volvulus Phospholipase A2 homolog 0.0723 0.4224 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0153 0.0181
Brugia malayi latrophilin 2 splice variant baaae 0.0073 0.0357 0.0423
Loa Loa (eye worm) hypothetical protein 0.0039 0.0153 0.0181
Echinococcus multilocularis musashi 0.0033 0.0115 0.0109
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0016 0.0015 0.0009
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0096 0.2702
Loa Loa (eye worm) histone methyltransferase 0.002 0.0041 0.0049
Echinococcus multilocularis integrin alpha ps 0.0071 0.0345 0.0339
Schistosoma mansoni DNA polymerase eta 0.0042 0.0174 0.0341
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0019 0.0034 0.0042
Mycobacterium ulcerans lipase/esterase 0.0022 0.0055 0.0115
Loa Loa (eye worm) hypothetical protein 0.0022 0.0055 0.0065
Loa Loa (eye worm) hypothetical protein 0.0034 0.0125 0.0147
Loa Loa (eye worm) hypothetical protein 0.0026 0.0076 0.0089
Loa Loa (eye worm) haloacid dehalogenase-like hydrolase 0.0021 0.0047 0.0056
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0057 0.0051
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0073 0.0355 0.0349
Echinococcus multilocularis transcription factor Dp 1 0.0042 0.0172 0.0166
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0026 0.0077 0.0161
Loa Loa (eye worm) peptidase family M13 containing protein 0.0341 0.1948 0.2304
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0322 0.1839 1
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0072 0.0353 0.0691
Loa Loa (eye worm) histone deacetylase 1 0.0043 0.0174 0.0206
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0019 0.0034 0.0042
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0016 0.0019 0.0019
Mycobacterium ulcerans proline iminopeptidase PIP 0.0022 0.0055 0.0115
Schistosoma mansoni hypothetical protein 0.0072 0.0353 0.0691
Brugia malayi intermediate filament protein 0.0033 0.0115 0.0136
Giardia lamblia NADH oxidase lateral transfer candidate 0.0014 0.0006 0.0032
Onchocerca volvulus Lipase homolog 0.0022 0.0055 0.0103
Echinococcus multilocularis histone deacetylase 1 0.0043 0.0174 0.0169
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0049 0.0211 0.0413
Brugia malayi haloacid dehalogenase-like hydrolase family protein 0.0021 0.0047 0.0056
Loa Loa (eye worm) acetyltransferase 0.016 0.0873 0.1032
Brugia malayi beta-lactamase family protein 0.0039 0.0153 0.0181
Mycobacterium tuberculosis Probable hydrolase 0.0021 0.0047 0.0087
Leishmania major histone deacetylase, putative 0.0043 0.0174 0.4918
Loa Loa (eye worm) histone deacetylase 3 0.0043 0.0174 0.0206
Echinococcus granulosus ephrin type A receptor 4 A 0.007 0.0339 0.0497
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0019 0.0034 0.0041
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0026 0.0076 0.3071
Loa Loa (eye worm) HAD-superfamily hydrolase 0.0021 0.0047 0.0056
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0022 0.0055 0.0278
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0014 0.0006 0.0012
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0143 0.0774 0.0768
Trypanosoma brucei unspecified product 0.0029 0.0096 0.2702
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0227 0.1269 0.1501
Mycobacterium tuberculosis Possible short-chain dehydrogenase EphD 0.003 0.01 0.0196
Plasmodium falciparum epoxide hydrolase 1 0.0022 0.0055 0.2241
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0073 0.0355 1
Trypanosoma brucei unspecified product 0.0042 0.0174 0.4913
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0043 0.0174 0.0929
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0014 0.0006 0.0242
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0021 0.0047 0.0237
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0019 0.0034 0.0041
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0019 0.0034 0.0041
Mycobacterium leprae probable zinc metalloprotease 0.0413 0.2379 1
Leishmania major hydrolase-like protein 0.0022 0.0055 0.1553
Plasmodium falciparum haloacid dehalogenase-like hydrolase, putative 0.0021 0.0047 0.1929
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0014 0.0006 0.0012
Mycobacterium tuberculosis Conserved protein 0.0039 0.0153 0.0308
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0174 0.4913
Trichomonas vaginalis glutathione reductase, putative 0.0014 0.0006 0.0011
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0014 0.0006 0.0168
Toxoplasma gondii aminopeptidase N protein 0.0026 0.0076 0.0317
Loa Loa (eye worm) hypothetical protein 0.0019 0.0034 0.0041
Brugia malayi CXXC zinc finger family protein 0.0061 0.0285 0.0337
Loa Loa (eye worm) TATA binding protein associated factor 0.0026 0.0076 0.0089
Leishmania major trypanothione reductase 0.0041 0.0165 0.4653
Onchocerca volvulus 0.0069 0.0335 0.0767
Plasmodium vivax ataxin-2 like protein, putative 0.0055 0.0246 1
Echinococcus multilocularis lamin 0.0033 0.0115 0.0109
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0019 0.0034 0.0041
Entamoeba histolytica acetyltransferase, GNAT family 0.0043 0.0178 0.0728
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0077 0.2175
Plasmodium vivax SET domain protein, putative 0.0034 0.0122 0.4947
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.0153 0.022
Loa Loa (eye worm) hypothetical protein 0.0032 0.0112 0.0132
Plasmodium falciparum histone acetyltransferase GCN5 0.0043 0.0178 0.7236
Echinococcus multilocularis lamin dm0 0.0033 0.0115 0.0109
Mycobacterium tuberculosis Conserved protein 0.0022 0.0055 0.0103
Echinococcus multilocularis GPCR, family 2 0.0034 0.0123 0.0117
Echinococcus multilocularis histone deacetylase 3 0.0043 0.0174 0.0169
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0019 0.0034 0.0041
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0093 0.0477 0.0986
Loa Loa (eye worm) aminopeptidase N 0.0049 0.0211 0.0249
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0103 0.0532 0.0785
Plasmodium falciparum acid cluster protein 33 homologue, putative 0.0022 0.0055 0.2241
Loa Loa (eye worm) hypothetical protein 0.0346 0.1977 0.2338
Brugia malayi hypothetical protein 0.0117 0.062 0.0733
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0047 0.0237
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0021 0.0047 0.0237
Echinococcus granulosus histone acetyltransferase KAT2B 0.0155 0.0846 0.1252
Loa Loa (eye worm) hypothetical protein 0.0346 0.1977 0.2338
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0322 0.1839 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.0122 0.0238
Mycobacterium tuberculosis Probable reductase 0.0093 0.0477 0.0986
Schistosoma mansoni RAR-like nuclear receptor 0.0019 0.0034 0.0067
Loa Loa (eye worm) hypothetical protein 0.0022 0.0055 0.0065
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0042 0.0174 0.0341
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0077 0.0127
Toxoplasma gondii homoserine O-acetyltransferase, putative 0.0022 0.0055 0.0232
Trypanosoma cruzi histone deacetylase 1, putative 0.0043 0.0174 0.4918
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0322 0.1839 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0077 0.0161
Echinococcus multilocularis thioredoxin glutathione reductase 0.0041 0.0168 0.0162
Entamoeba histolytica hypothetical protein 0.0036 0.0138 0.0508
Schistosoma mansoni hypothetical protein 0.0034 0.0123 0.0242
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0021 0.0047 0.0237
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0174 0.4913
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0014 0.0006 0.0168
Trichomonas vaginalis histone deacetylase, putative 0.0043 0.0174 0.0929
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.0174 0.4913
Brugia malayi hypothetical protein 0.0026 0.0076 0.0089
Echinococcus multilocularis dna polymerase kappa 0.0042 0.0174 0.0168
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.014 0.0755 0.1479
Loa Loa (eye worm) hypothetical protein 0.0034 0.0123 0.0146
Echinococcus granulosus abhydrolase domain containing protein 11 0.0022 0.0055 0.0073
Trypanosoma brucei hypothetical protein, conserved 0.0021 0.0047 0.1337
Brugia malayi Integrin alpha cytoplasmic region family protein 0.012 0.0636 0.0753
Echinococcus granulosus lysosomal acid lipase:cholesteryl ester 0.0022 0.0055 0.0073
Entamoeba histolytica hypothetical protein 0.0036 0.0138 0.0508
Schistosoma mansoni steroid hormone receptor ad4bp 0.0019 0.0034 0.0067
Loa Loa (eye worm) hypothetical protein 0.0016 0.0015 0.0018
Mycobacterium tuberculosis Probable lipase LipD 0.0039 0.0153 0.0308
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0047 0.0237
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0022 0.0055 0.0278
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0019 0.0034 0.0028
Entamoeba histolytica hypothetical protein 0.0036 0.0138 0.0508
Entamoeba histolytica hypothetical protein 0.0036 0.0138 0.0508
Mycobacterium tuberculosis Conserved hypothetical protein 0.0042 0.0174 0.0352
Loa Loa (eye worm) hypothetical protein 0.0042 0.0174 0.0206
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0115 0.0136
Echinococcus granulosus integrin alpha ps 0.0071 0.0345 0.0506
Mycobacterium ulcerans hypothetical protein 0.0022 0.0055 0.0115
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0329 0.0645
Leishmania major hydrolase, alpha/beta fold family-like protein 0.0022 0.0055 0.1553
Echinococcus granulosus abhydrolase domain containing protein 0.0022 0.0055 0.0073
Brugia malayi Hypothetical zinc metalloproteinase T16A9.4 0.0413 0.2379 0.2814
Mycobacterium tuberculosis Protein tyrosine kinase transcriptional regulatory protein PtkA 0.0021 0.0047 0.0087
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0019 0.0034 0.0041
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0016 0.0019 0.0037
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0014 0.0006 0.0168
Echinococcus granulosus integrin alpha 3 0.0122 0.0646 0.0954
Leishmania major hypothetical protein, conserved 0.0055 0.0246 0.6933
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0019 0.0034 0.0028
Mycobacterium ulcerans lipase LipD 0.0039 0.0153 0.032
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.0122 0.0173
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0021 0.0047 0.0237
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0025 0.003
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0093 0.0477 0.0986
Brugia malayi HAD-superfamily hydrolase, subfamily IA, variant 3 containing protein 0.0021 0.0047 0.0056
Schistosoma mansoni hypothetical protein 0.0034 0.0125 0.0244
Loa Loa (eye worm) hypothetical protein 0.0055 0.0246 0.0291
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0103 0.0532 0.063
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0123 0.0175
Echinococcus granulosus histone deacetylase 1 0.0043 0.0174 0.0251
Loa Loa (eye worm) ab-hydrolase associated lipase region family protein 0.0022 0.0055 0.0065
Toxoplasma gondii ABC1 family protein 0.0039 0.0153 0.0644
Schistosoma mansoni endothelin-converting enzyme-like 1 (damage-induced neuronal endopeptidase) 0.0068 0.0324 0.0635
Mycobacterium tuberculosis Possible haloalkane dehalogenase DhaA (1-chlorohexane halidohydrolase) 0.0022 0.0055 0.0103
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0153 0.0814
Leishmania major hypothetical protein, conserved 0.0022 0.0055 0.1553
Toxoplasma gondii peptidase family M13 protein 0.0413 0.2379 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0122 0.0238
Loa Loa (eye worm) hypothetical protein 0.0069 0.0335 0.0396
Loa Loa (eye worm) hypothetical protein 0.002 0.0038 0.0045
Brugia malayi RNA binding protein 0.0069 0.0329 0.0389
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0019 0.0034 0.0053
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0021 0.0047 0.0237
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0077 0.0091
Mycobacterium tuberculosis Possible epoxide hydrolase EphE (epoxide hydratase) (arene-oxide hydratase) 0.0022 0.0055 0.0103
Mycobacterium ulcerans DNA polymerase IV 0.0042 0.0174 0.0364
Mycobacterium ulcerans hydrolase 0.0021 0.0047 0.0099
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.0122 0.0116
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0049 0.0211 0.0205
Loa Loa (eye worm) thioredoxin reductase 0.0041 0.0165 0.0195
Toxoplasma gondii histone deacetylase HDAC2 0.0043 0.0174 0.0733
Brugia malayi hypothetical protein 0.0055 0.0246 0.0291
Entamoeba histolytica alpha/beta hydrolase domain protein, putative 0.0022 0.0055 0.0043
Plasmodium falciparum thioredoxin reductase 0.0041 0.0165 0.6712
Trichomonas vaginalis valacyclovir hydrolase, putative 0.0022 0.0055 0.0278
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0042 0.0174 0.0928
Loa Loa (eye worm) hypothetical protein 0.0107 0.0556 0.0658
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0014 0.0006 0.0168
Echinococcus granulosus FTZ F1 alpha 0.0019 0.0034 0.0042
Schistosoma mansoni hypothetical protein 0.0024 0.0067 0.0131
Mycobacterium ulcerans oxidoreductase 0.0022 0.0055 0.0115
Mycobacterium ulcerans hypothetical protein 0.0039 0.0153 0.032
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0077 0.2175
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0174 0.4913
Loa Loa (eye worm) hypothetical protein 0.0073 0.0357 0.0423
Brugia malayi Peptidase family M1 containing protein 0.0026 0.0076 0.0089
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.0153 0.0181
Mycobacterium ulcerans epoxide hydrolase EphF 0.0022 0.0055 0.0115
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0047 0.0237
Brugia malayi Peptidase family M1 containing protein 0.0133 0.071 0.084
Loa Loa (eye worm) hypothetical protein 0.0341 0.1948 0.2304
Loa Loa (eye worm) hypothetical protein 0.0015 0.0012 0.0014
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.002 0.0038 0.0067
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0021 0.0047 0.0237
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.0006 0.0168
Trichomonas vaginalis histone deacetylase, putative 0.0043 0.0174 0.0929
Mycobacterium ulcerans short chain dehydrogenase 0.003 0.01 0.0208
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0122 0.0511
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0019 0.0034 0.0028
Trichomonas vaginalis hydrolase, putative 0.0022 0.0055 0.0278
Mycobacterium leprae Probable homoserine o-acetyltransferase MetA 0.0022 0.0055 0.0033
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0055 0.1553
Mycobacterium ulcerans aminopeptidase N PepN 0.0049 0.0211 0.044
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0329 0.0645
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0049 0.0211 0.0413
Mycobacterium tuberculosis Probable oxidoreductase 0.0022 0.0055 0.0103
Treponema pallidum fructose-bisphosphate aldolase 0.0322 0.1839 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0122 0.0144
Plasmodium falciparum ataxin-2 like protein, putative 0.0055 0.0246 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0093 0.0477 0.0986
Loa Loa (eye worm) abhydrolase domain-containing protein 2 0.0022 0.0055 0.0065
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0073 0.0355 1
Echinococcus multilocularis haloacid dehalogenase hydrolase 0.0021 0.0047 0.0042
Giardia lamblia Hydrolase, haloacid dehalogenase-like family 0.0021 0.0047 0.0258
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0077 0.0127
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0073 0.0355 0.0419
Brugia malayi histone deacetylase 3 (HD3) 0.0043 0.0174 0.0206
Trichomonas vaginalis histone deacetylase, putative 0.0043 0.0174 0.0929
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0049 0.0211 0.0205
Mycobacterium ulcerans non-heme haloperoxidase Hpx 0.0022 0.0055 0.0115
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0019 0.0034 0.0067
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0024 0.0067 0.0091
Trichomonas vaginalis histone deacetylase, putative 0.0043 0.0174 0.0929
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0073 0.0355 0.0695
Loa Loa (eye worm) hypothetical protein 0.0107 0.0559 0.0661
Brugia malayi hypothetical protein 0.0036 0.0138 0.0164
Loa Loa (eye worm) hypothetical protein 0.0021 0.0047 0.0056
Treponema pallidum phosphoglycolate phosphatase 0.0021 0.0047 0.0226
Brugia malayi hypothetical protein 0.0035 0.0131 0.0155
Mycobacterium ulcerans 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD 0.0022 0.0055 0.0115
Toxoplasma gondii LsmAD domain-containing protein 0.0055 0.0246 0.1033
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0026 0.0076 0.3071
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0107 0.015
Toxoplasma gondii histone lysine methyltransferase SET1 0.0121 0.0641 0.2694
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0068 0.0324 0.0635
Echinococcus multilocularis haloacid dehalogenase hydrolase 0.0021 0.0047 0.0042
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.0034 0.0042
Brugia malayi nuclear hormone receptor 0.0019 0.0034 0.0041
Loa Loa (eye worm) hypothetical protein 0.0039 0.0153 0.0181
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0039 0.0153 0.0308
Echinococcus multilocularis muscleblind protein 0.0491 0.2841 0.2837
Toxoplasma gondii aminopeptidase N, putative 0.0026 0.0076 0.0317
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0026 0.0077 0.0161
Plasmodium falciparum thioredoxin reductase 0.0014 0.0006 0.0242
Brugia malayi ephrin receptor 1 precursor 0.0034 0.0121 0.0143
Schistosoma mansoni cpg binding protein 0.0061 0.0285 0.0559
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0068 0.0324 0.0635
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0021 0.0047 0.0237
Trypanosoma cruzi trypanothione reductase, putative 0.0041 0.0165 0.4653
Mycobacterium tuberculosis Possible haloalkane dehalogenase 0.0022 0.0055 0.0103
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.002 0.0041 0.0035
Trypanosoma cruzi aminopeptidase, putative 0.0026 0.0076 0.2129
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0026 0.0076 0.2129
Echinococcus granulosus histone acetyltransferase KAT2B 0.0047 0.0201 0.0291
Loa Loa (eye worm) hypothetical protein 0.0026 0.0076 0.0089
Loa Loa (eye worm) hypothetical protein 0.0019 0.0034 0.0041
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0019 0.0034 0.0041
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0123 0.0146
Trypanosoma cruzi hydrolase-like protein, putative 0.0022 0.0055 0.1553
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0057 0.1597
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0068 0.0324 0.0635
Plasmodium vivax hypothetical protein, conserved 0.0022 0.0055 0.2241
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0025 0.003
Brugia malayi MH2 domain containing protein 0.0129 0.0686 0.0811
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0019 0.0034 0.0042
Echinococcus multilocularis abhydrolase domain containing protein 3 0.0022 0.0055 0.0049
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0049 0.0211 0.5938
Schistosoma mansoni histone deacetylase 0.0043 0.0174 0.0342
Loa Loa (eye worm) hypothetical protein 0.0043 0.0174 0.0206
Leishmania major hypothetical protein, conserved 0.0039 0.0153 0.4323
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0047 0.0237
Onchocerca volvulus 0.0061 0.0285 0.0649
Schistosoma mansoni lamin 0.0033 0.0115 0.0226
Loa Loa (eye worm) hypothetical protein 0.0039 0.0153 0.0181
Brugia malayi Muscleblind-like protein 0.0491 0.2841 0.336
Loa Loa (eye worm) RNA binding protein 0.0069 0.0329 0.0389
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0077 0.0091
Loa Loa (eye worm) hypothetical protein 0.0015 0.0012 0.0014
Loa Loa (eye worm) hypothetical protein 0.0026 0.0076 0.0089
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0073 0.0355 1
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.016 0.0873 0.171
Plasmodium vivax histone deacetylase 1, putative 0.0043 0.0174 0.7093
Loa Loa (eye worm) peptidase family M1 containing protein 0.011 0.0575 0.068
Brugia malayi haloacid dehalogenase-like hydrolase family protein 0.0021 0.0047 0.0056
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0022 0.0055 0.0278
Schistosoma mansoni hypothetical protein 0.0073 0.0357 0.0701
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0077 0.2175
Echinococcus granulosus ecdysone induced protein 78C 0.0019 0.0034 0.0042
Leishmania major DNA polymerase kappa, putative 0.0042 0.0174 0.4913
Trypanosoma brucei PAB1-binding protein , putative 0.0055 0.0246 0.6933
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0322 0.1839 1
Echinococcus granulosus haloacid dehalogenase hydrolase 0.0021 0.0047 0.0062
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0322 0.1839 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0019 0.0034 0.0041
Brugia malayi beta-lactamase family protein 0.0039 0.0153 0.0181
Loa Loa (eye worm) haloacid dehalogenase-like hydrolase 0.0021 0.0047 0.0056
Echinococcus multilocularis abhydrolase domain containing 3 0.0022 0.0055 0.0049
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0103 0.0532 0.1044
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0021 0.0047 0.0237
Mycobacterium ulcerans hypothetical protein 0.0021 0.0047 0.0099
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0026 0.0076 0.2129
Leishmania major hydrolase-like protein,esterase-like protein 0.0022 0.0055 0.1553
Plasmodium falciparum glutathione reductase 0.0014 0.0006 0.0242
Onchocerca volvulus 0.0273 0.1546 0.3643
Brugia malayi RNA recognition motif domain containing protein 0.0069 0.0329 0.0389
Mycobacterium tuberculosis Possible phosphatase 0.0021 0.0047 0.0087
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0057 0.0106
Onchocerca volvulus 0.0033 0.0115 0.0245
Plasmodium vivax haloacid dehalogenase-like hydrolase, putative 0.0021 0.0047 0.1929
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0073 0.0355 0.1715
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0021 0.0047 0.0237
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0047 0.0237
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0055 0.1553
Trypanosoma brucei Aminopeptidase M1, putative 0.0049 0.0211 0.5938
Loa Loa (eye worm) CXXC zinc finger family protein 0.0061 0.0285 0.0337
Brugia malayi acetyltransferase, GNAT family protein 0.016 0.0873 0.1032
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0174 0.4913
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0026 0.0076 0.0148
Echinococcus granulosus mixed lineage leukemia protein mll 0.0016 0.0019 0.0019
Onchocerca volvulus 0.0021 0.0047 0.0084
Trypanosoma cruzi hydrolase-like protein 0.0022 0.0055 0.1553
Echinococcus multilocularis abhydrolase domain containing protein 16A 0.0022 0.0055 0.0049
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0174 0.4913
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0329 0.0645
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0057 0.0067
Schistosoma mansoni thyroid hormone receptor 0.0019 0.0034 0.0067
Echinococcus granulosus GPCR family 2 0.0034 0.0123 0.0175
Mycobacterium ulcerans epoxide hydrolase EphB 0.0022 0.0055 0.0115
Loa Loa (eye worm) transcription factor SMAD2 0.0129 0.0686 0.0811
Plasmodium vivax alpha/beta hydrolase, putative 0.0022 0.0055 0.2241
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0047 0.0201 0.0846
Brugia malayi Hypothetical 54.7 kDa protein F37A4.1 in chromosome III 0.0022 0.0055 0.0065
Trypanosoma brucei trypanothione reductase 0.0041 0.0165 0.4653
Onchocerca volvulus 0.0039 0.0153 0.0336
Mycobacterium tuberculosis Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase) 0.0818 0.4785 1
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0021 0.0047 0.0237
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0123 0.0117
Loa Loa (eye worm) glutathione reductase 0.0041 0.0165 0.0195
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0019 0.0034 0.0042
Brugia malayi Phospholipase A2 family protein 0.0723 0.4224 0.4995
Loa Loa (eye worm) integrin alpha pat-2 0.0245 0.1378 0.163
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.0034 0.0028
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0061 0.0128
Mycobacterium ulcerans hypothetical protein 0.0022 0.0055 0.0115
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0019 0.0034 0.0042
Schistosoma mansoni neprilysin 0.0072 0.0353 0.0691
Brugia malayi TATA binding protein associated factor 0.0026 0.0076 0.0089
Plasmodium vivax thioredoxin reductase, putative 0.0041 0.0165 0.6712
Onchocerca volvulus 0.0034 0.0122 0.0261
Loa Loa (eye worm) hypothetical protein 0.0026 0.0077 0.0091
Loa Loa (eye worm) hypothetical protein 0.0026 0.0077 0.0091
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0019 0.0034 0.0041
Mycobacterium ulcerans hypothetical protein 0.0026 0.0077 0.0161
Giardia lamblia Phosphoglycolate phosphatase 0.0021 0.0047 0.0258
Trypanosoma brucei Aminopeptidase M1, putative 0.0049 0.0211 0.5938
Echinococcus multilocularis integrin alpha 3 0.0122 0.0646 0.064
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0138 0.0197
Loa Loa (eye worm) hypothetical protein 0.0026 0.0077 0.0091
Echinococcus granulosus aminopeptidase N 0.0133 0.071 0.105
Schistosoma mansoni hypothetical protein 0.0034 0.0123 0.0242
Mycobacterium ulcerans peroxidase BpoB 0.0022 0.0055 0.0115
Toxoplasma gondii thioredoxin reductase 0.0041 0.0165 0.0694
Brugia malayi photoreceptor-specific nuclear receptor 0.0019 0.0034 0.0041
Onchocerca volvulus 0.0039 0.0153 0.0336
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0049 0.0211 0.0305
Brugia malayi UPF0017 protein CG3488 0.0022 0.0055 0.0065
Entamoeba histolytica acyl-coA synthetase, putative 0.0026 0.0077 0.0166
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0077 0.0161
Brugia malayi hydrolase, alpha/beta fold family protein 0.0022 0.0055 0.0065
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0031 0.0053
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0077 0.0166
Loa Loa (eye worm) hypothetical protein 0.0023 0.0057 0.0067
Loa Loa (eye worm) hypothetical protein 0.0125 0.0663 0.0785
Schistosoma mansoni lamin 0.0033 0.0115 0.0226
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.0006 0.0168
Loa Loa (eye worm) hypothetical protein 0.0273 0.1546 0.1828
Mycobacterium ulcerans zinc metalloprotease 0.0413 0.2379 0.4973
Echinococcus granulosus Solute carrier family 22 5 0.1142 0.6713 1
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0049 0.0211 0.5938
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0042 0.0174 0.0206
Echinococcus multilocularis ecdysone induced protein 78C 0.0019 0.0034 0.0028
Mycobacterium ulcerans haloalkane dehalogenase 0.0022 0.0055 0.0115
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0174 0.4913
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0049 0.0211 0.1126
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0322 0.1839 1
Echinococcus granulosus transcription factor Dp 1 0.0042 0.0172 0.0248
Loa Loa (eye worm) hypothetical protein 0.0346 0.1977 0.2338
Brugia malayi Histone deacetylase 1 0.0043 0.0174 0.0206

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.0282 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.0119 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 29.081 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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