Detailed information for compound 151930

Basic information

Technical information
  • TDR Targets ID: 151930
  • Name: (2R)-N-(4-benzoyl-2-chlorophenyl)-3,3,3-trifl uoro-2-hydroxy-2-methylpropanamide
  • MW: 371.738 | Formula: C17H13ClF3NO3
  • H donors: 2 H acceptors: 3 LogP: 3.75 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccc(c(c1)Cl)NC(=O)[C@](C(F)(F)F)(O)C)c1ccccc1
  • InChi: 1S/C17H13ClF3NO3/c1-16(25,17(19,20)21)15(24)22-13-8-7-11(9-12(13)18)14(23)10-5-3-2-4-6-10/h2-9,25H,1H3,(H,22,24)/t16-/m1/s1
  • InChiKey: FSMLYTJJLFECDK-MRXNPFEDSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2R)-N-(4-benzoyl-2-chloro-phenyl)-3,3,3-trifluoro-2-hydroxy-2-methyl-propanamide
  • (2R)-N-[2-chloro-4-(phenylcarbonyl)phenyl]-3,3,3-trifluoro-2-hydroxy-2-methyl-propanamide
  • (2R)-N-(4-benzoyl-2-chloro-phenyl)-3,3,3-trifluoro-2-hydroxy-2-methyl-propionamide
  • (2R)-N-[4-(benzoyl)-2-chlorophenyl]-3,3,3-trifluoro-2-hydroxy-2-methylpropanamide
  • (2R)-N-[4-(benzoyl)-2-chloro-phenyl]-3,3,3-trifluoro-2-hydroxy-2-methyl-propanamide
  • (2R)-N-[2-chloro-4-(oxo-phenylmethyl)phenyl]-3,3,3-trifluoro-2-hydroxy-2-methylpropanamide
  • (2R)-N-[4-(benzoyl)-2-chloro-phenyl]-3,3,3-trifluoro-2-hydroxy-2-methyl-propionamide
  • (2R)-N-(2-chloro-4-phenylcarbonyl-phenyl)-3,3,3-trifluoro-2-hydroxy-2-methyl-propanamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens pyruvate dehydrogenase kinase, isozyme 3 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase Get druggable targets OG5_127409 All targets in OG5_127409
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase Get druggable targets OG5_127409 All targets in OG5_127409
Schistosoma mansoni pyruvate dehydrogenase Get druggable targets OG5_127409 All targets in OG5_127409
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127409 All targets in OG5_127409
Schistosoma japonicum ko:K00898 pyruvate dehydrogenase kinase [EC2.7.11.2], putative Get druggable targets OG5_127409 All targets in OG5_127409
Schistosoma japonicum [Pyruvate dehydrogenase [lipoamide]] kinase, mitochondrial precursor, putative Get druggable targets OG5_127409 All targets in OG5_127409
Leishmania donovani developmentally regulated phosphoprotein-like protein Get druggable targets OG5_127409 All targets in OG5_127409
Leishmania mexicana developmentally regulated phosphoprotein-like protein Get druggable targets OG5_127409 All targets in OG5_127409
Trypanosoma cruzi developmentally regulated phosphoprotein, putative Get druggable targets OG5_127409 All targets in OG5_127409
Leishmania braziliensis developmentally regulated phosphoprotein-like protein Get druggable targets OG5_127409 All targets in OG5_127409
Trypanosoma brucei developmentally regulated phosphoprotein Get druggable targets OG5_127409 All targets in OG5_127409
Brugia malayi kinase, mitochondrial precursor Get druggable targets OG5_127409 All targets in OG5_127409
Trypanosoma congolense developmentally regulated phosphoprotein, putative Get druggable targets OG5_127409 All targets in OG5_127409
Leishmania infantum developmentally regulated phosphoprotein-like protein Get druggable targets OG5_127409 All targets in OG5_127409
Trypanosoma brucei gambiense developmentally regulated phosphoprotein Get druggable targets OG5_127409 All targets in OG5_127409
Leishmania major developmentally regulated phosphoprotein-like protein Get druggable targets OG5_127409 All targets in OG5_127409
Candida albicans similar to S. pombe SPAC644.11c predicted pyruvate dehydrogenase kinase Get druggable targets OG5_127409 All targets in OG5_127409
Schistosoma mansoni pyruvate dehydrogenase Get druggable targets OG5_127409 All targets in OG5_127409
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase Get druggable targets OG5_127409 All targets in OG5_127409
Schistosoma mansoni pyruvate dehydrogenase Get druggable targets OG5_127409 All targets in OG5_127409
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei pyruvate dehydrogenase (lipoamide) kinase, putative pyruvate dehydrogenase kinase, isozyme 3 415 aa 360 aa 23.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0057 0.0473 0.0715
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0328 0.0546
Brugia malayi Muscleblind-like protein 0.0167 0.1645 0.1644
Entamoeba histolytica hypothetical protein, conserved 0.0122 0.116 0.5501
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0079 0.0288
Schistosoma mansoni pyruvate dehydrogenase 0.0543 0.565 0.9431
Brugia malayi F/Y-rich N-terminus family protein 0.0024 0.0119 0.0118
Plasmodium vivax DNA topoisomerase II, putative 0.0032 0.0206 0.253
Entamoeba histolytica DNA topoisomerase II, putative 0.0032 0.0206 0.0972
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0043 0.0154
Brugia malayi MAP kinase sur-1 0.0057 0.0473 0.0471
Treponema pallidum biotin--acetyl-CoA-carboxylase ligase 0.0406 0.4187 1
Schistosoma mansoni hypothetical protein 0.0324 0.332 0.5542
Schistosoma mansoni DNA topoisomerase II 0.0032 0.0206 0.0342
Trichomonas vaginalis set domain proteins, putative 0.0266 0.2695 1
Wolbachia endosymbiont of Brugia malayi membrane associated signal transduction histidine kinase 0.0032 0.0206 0.0967
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0575 0.599 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0017 0.0043 0.0154
Mycobacterium ulcerans two component sensor kinase MprB 0.0032 0.0206 0.0173
Echinococcus granulosus mitogen activated protein kinase 3 0.0057 0.0473 0.0787
Brugia malayi Pre-SET motif family protein 0.0034 0.0229 0.0227
Leishmania major hypothetical protein, conserved 0.0032 0.0206 0.0267
Toxoplasma gondii histone lysine methyltransferase SET1 0.0068 0.0594 0.2526
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.0473 0.1749
Plasmodium falciparum lipoate-protein ligase 1 0.0026 0.0141 0.173
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.021 0.2108 0.3467
Schistosoma mansoni jumonji domain containing protein 0.0085 0.0769 0.1282
Trypanosoma cruzi peptidase, putative 0.0027 0.0151 0.0174
Entamoeba histolytica hypothetical protein, conserved 0.0058 0.0486 0.2301
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0025 0.0134 0.0492
Schistosoma mansoni sex comb on midleg homolog 0.0053 0.0434 0.0722
Leishmania major heat shock protein 83-1 0.0032 0.0206 0.0267
Trichomonas vaginalis inositol monophosphatase, putative 0.0041 0.0306 0.1129
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0053 0.0432 0.0719
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0206 0.0267
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0229 0.0969
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.0473 0.1749
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.0032 0.0206 0.253
Loa Loa (eye worm) MBCTL1 0.0061 0.0513 0.0511
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.0032 0.0206 0.178
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0037 0.026 0.3092
Leishmania major heat shock protein 83-1 0.0032 0.0206 0.0267
Plasmodium vivax heat shock protein 86, putative 0.0032 0.0206 0.253
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.021 0.2108 0.3518
Toxoplasma gondii lipoyl(octanoyl) transferase 0.0026 0.0141 0.0595
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0208 0.0345
Trypanosoma cruzi Biotin--acetyl-CoA-carboxylase ligase, putative 0.0089 0.0815 0.1291
Loa Loa (eye worm) acetyltransferase 0.0152 0.1483 0.1482
Loa Loa (eye worm) intermediate filament protein 0.003 0.0187 0.0185
Brugia malayi CXXC zinc finger family protein 0.0032 0.0208 0.0206
Loa Loa (eye worm) jmjC domain-containing protein 0.0043 0.0328 0.0327
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0053 0.0434 0.0433
Toxoplasma gondii heat shock protein HSP90 0.0032 0.0206 0.0873
Loa Loa (eye worm) hypothetical protein 0.0026 0.0141 0.014
Schistosoma mansoni insulysin unit 3 (M16 family) 0.0027 0.0151 0.025
Loa Loa (eye worm) hypothetical protein 0.0043 0.0323 0.0321
Echinococcus granulosus single minded 2 0.0072 0.063 0.105
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0233 0.2353 0.2352
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0057 0.0473 0.0715
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0037 0.026 0.0293
Brugia malayi chromobox protein homolog 3 0.0044 0.0331 0.0329
Wolbachia endosymbiont of Brugia malayi biotin-(acetyl-CoA carboxylase) ligase 0.0089 0.0815 1
Echinococcus multilocularis polycomb protein SCMH1 0.0053 0.0434 0.0722
Echinococcus multilocularis musashi 0.003 0.0187 0.031
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0032 0.0206 0.0173
Schistosoma mansoni insulysin (M16 family) 0.0015 0.0024 0.0038
Echinococcus multilocularis nardilysin 0.0016 0.0038 0.0062
Loa Loa (eye worm) mbt repeat family protein 0.0053 0.0434 0.0433
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0575 0.599 1
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0026 0.014 0.0154
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0079 0.0288
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0032 0.0206 0.0161
Schistosoma mansoni inositol monophosphatase 0.0041 0.0306 0.0508
Plasmodium falciparum DNA topoisomerase 2 0.0032 0.0206 0.253
Trichomonas vaginalis DNA topoisomerase II, putative 0.0032 0.0206 0.076
Echinococcus multilocularis chromobox protein 1 0.0078 0.0696 0.1159
Schistosoma mansoni nardilysin (M16 family) 0.0027 0.0151 0.025
Echinococcus granulosus Chromobox protein 3 0.0013 0.0001 0.000000024875
Brugia malayi acetyltransferase, GNAT family protein 0.0152 0.1483 0.1482
Loa Loa (eye worm) hypothetical protein 0.0951 1 1
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0032 0.0206 0.076
Trypanosoma cruzi peptidase, putative 0.0027 0.0151 0.0174
Schistosoma mansoni insulysin unit 3 (M16 family) 0.0027 0.0151 0.025
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0032 0.0206 0.0267
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0053 0.0432 0.0719
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0032 0.0206 0.0967
Trypanosoma brucei pyruvate dehydrogenase (lipoamide) kinase, putative 0.0201 0.2007 0.3296
Echinococcus multilocularis chromobox protein 1 0.0078 0.0696 0.1159
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0079 0.0288
Entamoeba histolytica heat shock protein 90, putative 0.0032 0.0206 0.0972
Brugia malayi Probable DNA topoisomerase II 0.0032 0.0206 0.0205
Plasmodium falciparum biotin--acetyl-CoA-carboxylase, putative 0.0089 0.0815 1
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0025 0.0134 0.0145
Entamoeba histolytica hypothetical protein, conserved 0.0122 0.116 0.5501
Brugia malayi lipoate-protein ligase, mitochondrial precursor, putative 0.0026 0.0141 0.014
Echinococcus multilocularis lamin 0.003 0.0187 0.031
Leishmania major heat shock protein 83-1 0.0032 0.0206 0.0267
Plasmodium vivax heterochromatin protein 1, putative 0.0013 0.0001 0.0018
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0072 0.0635 0.1058
Mycobacterium tuberculosis Probable two component sensor kinase 0.0032 0.0206 0.0161
Loa Loa (eye worm) hypothetical protein 0.0325 0.3331 0.333
Schistosoma mansoni lamin 0.003 0.0187 0.031
Trichomonas vaginalis chromobox protein, putative 0.0078 0.0696 0.2577
Echinococcus granulosus chromobox protein 1 0.0078 0.0696 0.1159
Loa Loa (eye worm) hypothetical protein 0.0951 1 1
Echinococcus granulosus chromobox protein 1 0.0078 0.0696 0.1159
Trichomonas vaginalis chromobox protein, putative 0.0047 0.0366 0.1354
Schistosoma mansoni aryl hydrocarbon receptor 0.0097 0.0899 0.1498
Schistosoma mansoni hypothetical protein 0.0017 0.0048 0.0077
Leishmania major biotin/lipoate protein ligase-like protein 0.0089 0.0815 0.1291
Echinococcus multilocularis cpg binding protein 0.0036 0.025 0.0415
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0069 0.0112
Loa Loa (eye worm) hypothetical protein 0.0053 0.0432 0.0431
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0032 0.0206 0.076
Plasmodium falciparum heterochromatin protein 1 0.0013 0.0001 0.0018
Trypanosoma brucei DNA topoisomerase ii 0.0032 0.0206 0.0267
Trichomonas vaginalis chromobox protein, putative 0.0078 0.0696 0.2577
Loa Loa (eye worm) bromodomain containing protein 0.0023 0.0115 0.0114
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0032 0.0206 0.0873
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0027 0.0154 0.0254
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0014 0.002 0.0031
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.021 0.2108 1
Trypanosoma cruzi Biotin--acetyl-CoA-carboxylase ligase, putative 0.0089 0.0815 0.1291
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0069 0.0112
Echinococcus granulosus 3'partial|nardilysin 0.0027 0.0151 0.025
Onchocerca volvulus Lipoyltransferase 1, mitochondrial homolog 0.0026 0.0141 0.014
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.021 0.2108 0.2107
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.021 0.2108 0.3518
Entamoeba histolytica hypothetical protein, conserved 0.0122 0.116 0.5501
Trypanosoma brucei protein kinase, putative 0.0057 0.0473 0.0715
Loa Loa (eye worm) inositol-1 0.0041 0.0306 0.0304
Leishmania major heat shock protein 83-1 0.0032 0.0206 0.0267
Schistosoma mansoni pyruvate dehydrogenase 0.0543 0.565 0.9431
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0032 0.0206 0.0205
Loa Loa (eye worm) hypothetical protein 0.0079 0.0708 0.0707
Brugia malayi jmjC domain containing protein 0.0107 0.1003 0.1002
Entamoeba histolytica hypothetical protein, conserved 0.0122 0.116 0.5501
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0047 0.0365 0.0606
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0038 0.0036
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0079 0.0288
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0032 0.0206 0.0205
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0047 0.0366 0.0365
Loa Loa (eye worm) heterochromatin protein 1 0.0078 0.0696 0.0694
Echinococcus granulosus tyrosine protein kinase ABL1 0.0235 0.2369 0.3953
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0152 0.1483 0.2474
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0053 0.0434 0.0722
Trichomonas vaginalis guanylate cyclase, putative 0.0025 0.0134 0.0492
Toxoplasma gondii insulysin, putative 0.0025 0.0137 0.0578
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0032 0.0206 0.0161
Schistosoma mansoni single-minded 0.0097 0.0899 0.1498
Leishmania major heat shock protein 83-1 0.0032 0.0206 0.0267
Schistosoma mansoni biotin-protein ligase 0.0122 0.116 0.1935
Giardia lamblia Histone acetyltransferase GCN5 0.004 0.0294 0.1441
Toxoplasma gondii rhoptry metalloprotease toxolysin TLN1 0.0027 0.0151 0.0638
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0025 0.0134 0.0492
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0032 0.0206 0.0173
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0206 0.0267
Trypanosoma cruzi DNA topoisomerase II, putative 0.0032 0.0206 0.0267
Loa Loa (eye worm) jmjC domain-containing protein 0.0067 0.0583 0.0581
Leishmania major heat shock protein 83-1 0.0032 0.0206 0.0267
Echinococcus multilocularis muscleblind protein 1 0.0167 0.1645 0.2745
Mycobacterium leprae Probable two component sensor kinase MprB 0.0032 0.0206 0.178
Mycobacterium ulcerans putative regultory protein 0.0032 0.0206 0.0173
Plasmodium vivax hypothetical protein, conserved 0.0013 0.0001 0.0018
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0032 0.0206 0.0173
Brugia malayi Bromodomain containing protein 0.0046 0.0361 0.0359
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0026 0.014 0.0154
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0032 0.0206 0.0173
Loa Loa (eye worm) TOPoisomerase family member 0.0032 0.0206 0.0205
Echinococcus multilocularis peregrin 0.0039 0.028 0.0465
Trypanosoma brucei heat shock protein, putative 0.0032 0.0206 0.0267
Entamoeba histolytica biotin--acetyl-CoA-carboxylase ligase, putative 0.0089 0.0815 0.3863
Leishmania major heat shock protein 83-1 0.0032 0.0206 0.0267
Toxoplasma gondii peptidase M16 inactive domain-containing protein 0.0016 0.0038 0.0157
Echinococcus multilocularis transcription factor Dp 1 0.0122 0.1164 0.1941
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0032 0.0206 0.0161
Plasmodium falciparum endoplasmin, putative 0.0032 0.0206 0.253
Entamoeba histolytica heat shock protein 90, putative 0.0032 0.0206 0.0972
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0026 0.014 0.0154
Echinococcus granulosus nardilysin 0.0027 0.0151 0.025
Echinococcus granulosus mitogen activated protein kinase 0.0057 0.0473 0.0787
Onchocerca volvulus 0.003 0.0187 0.0185
Brugia malayi bHLH-PAS transcription factor 0.0072 0.063 0.0629
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0032 0.0206 0.0267
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.0032 0.0206 0.0161
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0032 0.0206 0.0205
Schistosoma mansoni heat shock protein 0.0032 0.0206 0.0342
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0032 0.0206 0.0161
Echinococcus multilocularis lysine specific demethylase 5A 0.0039 0.0286 0.0475
Schistosoma mansoni inositol monophosphatase 0.0041 0.0306 0.0508
Echinococcus multilocularis heat shock protein 0.0032 0.0206 0.0342
Brugia malayi hypothetical protein 0.0325 0.3331 0.333
Chlamydia trachomatis DNA gyrase subunit B 0.0032 0.0206 0.064
Echinococcus multilocularis transfer RNA-Lys 0.0072 0.063 0.105
Echinococcus multilocularis octanoyltransferase, mitochondrial 0.0026 0.0141 0.0233
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0032 0.0206 0.0267
Brugia malayi Heterochromatin protein 1 0.0078 0.0696 0.0694
Mycobacterium tuberculosis Possible bifunctional protein BirA: biotin operon repressor + biotin--[acetyl-CoA-carboxylase] synthetase (biotin--protein ligas 0.0063 0.054 0.0986
Brugia malayi Pre-SET motif family protein 0.0233 0.2353 0.2352
Echinococcus granulosus PHD finger protein rhinoceros 0.0033 0.0213 0.0353
Trypanosoma brucei peptidase, putative 0.0027 0.0151 0.0174
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0032 0.0206 0.0342
Echinococcus multilocularis insulin degrading enzyme 0.0027 0.0151 0.025
Brugia malayi biotin--acetyl-CoA-carboxylase ligase family protein 0.0089 0.0815 0.0814
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.004 0.0294 0.0488
Schistosoma mansoni endoplasmin 0.0032 0.0206 0.0342
Leishmania major heat shock protein 83-1 0.0032 0.0206 0.0267
Mycobacterium tuberculosis Possible two component sensor kinase 0.0032 0.0206 0.0161
Schistosoma mansoni lipoate-protein ligase B 0.0026 0.0141 0.0233
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0206 0.0267
Echinococcus granulosus transcription factor Dp 1 0.0122 0.1164 0.1941
Toxoplasma gondii heat shock protein 90, putative 0.0032 0.0206 0.0873
Echinococcus granulosus inositol monophosphatase 1 0.0041 0.0306 0.0508
Echinococcus granulosus aryl hydrocarbon receptor 0.0025 0.0134 0.0221
Echinococcus granulosus muscleblind protein 0.0167 0.1645 0.2745
Trichomonas vaginalis receptor histidine kinase, putative 0.0032 0.0206 0.076
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0152 0.1483 0.2474
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0032 0.0206 0.0161
Loa Loa (eye worm) hypothetical protein 0.0034 0.023 0.0229
Onchocerca volvulus 0.0266 0.2695 0.2694
Leishmania major heat shock protein 83-1 0.0032 0.0206 0.0267
Schistosoma mansoni zinc finger protein 0.0027 0.0157 0.026
Loa Loa (eye worm) hypothetical protein 0.0015 0.0021 0.002
Schistosoma mansoni hypothetical protein 0.0457 0.4739 0.791
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0187 0.0185
Schistosoma mansoni hypothetical protein 0.0023 0.0111 0.0184
Brugia malayi PHD-finger family protein 0.0033 0.0221 0.0219
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0032 0.0206 0.0267
Echinococcus multilocularis Chromobox protein 3 0.0013 0.0001 0.000000024875
Echinococcus granulosus lamin 0.003 0.0187 0.031
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0079 0.0288
Echinococcus granulosus cpg binding protein 0.0036 0.025 0.0415
Schistosoma mansoni hypothetical protein 0.0033 0.0213 0.0353
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0032 0.0206 0.0161
Plasmodium falciparum heat shock protein 90 0.0032 0.0206 0.253
Plasmodium falciparum histone acetyltransferase GCN5 0.004 0.0294 0.3607
Trichomonas vaginalis lipoate-protein ligase, putative 0.0026 0.0141 0.0518
Brugia malayi MH2 domain containing protein 0.0124 0.119 0.1189
Trypanosoma cruzi pyruvate dehydrogenase (lipoamide) kinase, putative 0.0201 0.2007 0.3296
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0041 0.0306 0.1297
Schistosoma mansoni mixed-lineage leukemia protein mll 0.002 0.0077 0.0126
Loa Loa (eye worm) hypothetical protein 0.0044 0.0331 0.0329
Brugia malayi lipoate-protein ligase B containing protein 0.0026 0.0141 0.014
Leishmania major heat shock protein 83-1 0.0032 0.0206 0.0267
Brugia malayi intermediate filament protein 0.003 0.0187 0.0185
Trypanosoma cruzi lipoate-protein ligase, putative 0.0026 0.0141 0.0157
Trypanosoma brucei heat shock protein, putative 0.0032 0.0206 0.0267
Echinococcus multilocularis nardilysin 0.0027 0.0151 0.025
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0047 0.0361 0.1336
Trichomonas vaginalis guanylate cyclase, putative 0.0025 0.0134 0.0492
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0032 0.0206 0.0205
Loa Loa (eye worm) PHD-finger family protein 0.0023 0.0111 0.011
Mycobacterium ulcerans bifunctional protein BirA 0.038 0.3911 1
Loa Loa (eye worm) heat shock protein 90 0.0032 0.0206 0.0205
Entamoeba histolytica hypothetical protein, conserved 0.0058 0.0486 0.2301
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0107 0.1003 0.1673
Loa Loa (eye worm) runx1 0.0119 0.1137 0.1136
Brugia malayi CHD4 protein 0.0017 0.0044 0.0042
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0032 0.0206 0.0173
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0033 0.0213 0.0353
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0208 0.0206
Schistosoma mansoni chromobox protein 0.0078 0.0696 0.1159
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0057 0.0473 0.2009
Echinococcus multilocularis SAM and MBT domain containing protein 0.0053 0.0434 0.0722
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0069 0.0604 0.1007
Schistosoma mansoni serine/threonine protein kinase 0.0057 0.0473 0.0787
Loa Loa (eye worm) hypothetical protein 0.0014 0.0015 0.0013
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0057 0.0473 0.0715
Echinococcus multilocularis histone acetyltransferase MYST2 0.0061 0.0513 0.0853
Loa Loa (eye worm) hypothetical protein 0.003 0.0181 0.018
Loa Loa (eye worm) transcription factor SMAD2 0.0124 0.119 0.1189
Entamoeba histolytica hypothetical protein, conserved 0.0122 0.116 0.5501
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0032 0.0206 0.076
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0079 0.0288
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0025 0.0134 0.0492
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.021 0.2108 0.2107
Loa Loa (eye worm) TK/ABL protein kinase 0.0235 0.2369 0.2368
Echinococcus granulosus jumonji domain containing protein 0.0045 0.0349 0.058
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0041 0.0306 0.1129
Plasmodium falciparum biotin protein ligase, putative 0.0089 0.0815 1
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0013 0.0001 0.0018
Onchocerca volvulus 0.0951 1 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.039 0.0388
Trypanosoma cruzi Heat shock protein 83, putative 0.0032 0.0206 0.0267
Trypanosoma cruzi DNA topoisomerase II, putative 0.0032 0.0206 0.0267
Echinococcus granulosus histone lysine methyltransferase setb 0.0053 0.0432 0.0719
Chlamydia trachomatis biotin synthetase 0.0089 0.0815 0.6615
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0032 0.0206 0.0161
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0047 0.0361 0.1534
Plasmodium vivax endoplasmin, putative 0.0032 0.0206 0.253
Echinococcus granulosus SAM and MBT domain containing protein 0.0053 0.0434 0.0722
Trypanosoma brucei heat shock protein 90, putative 0.0032 0.0206 0.0267
Brugia malayi insulin-degrading enzyme 0.0027 0.0151 0.015
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0195 0.0719
Brugia malayi Bromodomain containing protein 0.0039 0.028 0.0279
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.0032 0.0206 0.0173
Echinococcus granulosus methyl CpG binding domain protein 2 0.0019 0.0069 0.0112
Plasmodium vivax lipoate-protein ligase 1, putative 0.0026 0.0141 0.173
Onchocerca volvulus 0.0047 0.0365 0.0363
Loa Loa (eye worm) hypothetical protein 0.0053 0.0434 0.0433
Entamoeba histolytica hypothetical protein, conserved 0.0122 0.116 0.5501
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0013 0.0001 0.0018
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.0473 0.1749
Echinococcus granulosus polycomb protein SCMH1 0.0053 0.0434 0.0722
Toxoplasma gondii sporozoite developmental protein 0.0027 0.0151 0.0638
Chlamydia trachomatis hypothetical protein 0.0122 0.116 1
Brugia malayi mbt repeat family protein 0.0053 0.0434 0.0433
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0575 0.599 1
Trichomonas vaginalis heat shock protein, putative 0.0032 0.0206 0.076
Trichomonas vaginalis receptor histidine kinase, putative 0.0032 0.0206 0.076
Mycobacterium ulcerans two component regulator - sensor kinase 0.0032 0.0206 0.0173
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0057 0.0473 0.0471
Leishmania major heat shock protein 83-1 0.0032 0.0206 0.0267
Echinococcus multilocularis zinc finger protein 0.0027 0.0157 0.026
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0025 0.0134 0.0133
Echinococcus multilocularis dnaJ subfamily B 0.0457 0.4739 0.791
Echinococcus multilocularis mitogen activated protein kinase 0.0057 0.0473 0.0787
Loa Loa (eye worm) hypothetical protein 0.0167 0.1645 0.1644
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0057 0.0473 0.0715
Echinococcus granulosus fetal alzheimer antigen falz 0.0027 0.0154 0.0254
Echinococcus multilocularis mitogen activated protein kinase 3 0.0057 0.0473 0.0787
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0328 0.0546
Plasmodium vivax SET domain protein, putative 0.0034 0.0229 0.2805
Giardia lamblia Hypothetical protein 0.0089 0.0815 1
Echinococcus granulosus endonuclease exonuclease phosphatase 0.021 0.2105 0.3513
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0079 0.0288
Loa Loa (eye worm) hypothetical protein 0.0015 0.0021 0.0019
Echinococcus granulosus lamin dm0 0.003 0.0187 0.031
Trypanosoma brucei Biotin--acetyl-CoA-carboxylase ligase, putative 0.0089 0.0815 0.1291
Schistosoma mansoni zinc finger protein 0.0017 0.0048 0.0077
Leishmania major heat shock protein 83-1 0.0032 0.0206 0.0267
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0032 0.0206 0.076
Leishmania major pyruvate dehydrogenase (lipoamide) kinase, putative 0.0201 0.2007 0.3296
Schistosoma mansoni intermediate filament proteins 0.003 0.0187 0.031
Echinococcus granulosus histone acetyltransferase MYST2 0.0061 0.0513 0.0853
Trichomonas vaginalis chromobox protein, putative 0.0047 0.0366 0.1354
Brugia malayi heat shock protein 90 0.0032 0.0206 0.0205
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.021 0.2108 0.3467
Onchocerca volvulus 0.0032 0.0208 0.0206
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0016 0.0037 0.0133
Loa Loa (eye worm) insulin-degrading enzyme 0.0027 0.0151 0.015
Loa Loa (eye worm) biotin protein ligase 1 0.0089 0.0815 0.0814
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0187 0.0185
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0229 0.0379
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0306 0.0434
Schistosoma mansoni sex comb on midleg homolog 0.0053 0.0434 0.0722
Echinococcus multilocularis jumonji domain containing protein 0.0045 0.0349 0.058
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0015 0.0021 0.0032
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0017 0.0044 0.0071
Onchocerca volvulus 0.003 0.0187 0.0185
Schistosoma mansoni hypothetical protein 0.0189 0.1884 0.3144
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.021 0.2108 0.3518
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0057 0.0473 0.0715
Loa Loa (eye worm) hypothetical protein 0.003 0.0187 0.0185
Brugia malayi PAS domain containing protein 0.0097 0.0899 0.0897
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.021 0.2108 0.3467
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0057 0.0473 0.0715
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0025 0.0134 0.0221
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0026 0.014 0.0154
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.004 0.0294 0.0488
Trypanosoma brucei heat shock protein, putative 0.0032 0.0206 0.0267
Echinococcus granulosus histone acetyltransferase KAT2B 0.0145 0.141 0.2353
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0017 0.0044 0.0071
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0072 0.0635 0.1058
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0015 0.0021 0.0032
Brugia malayi kinase, mitochondrial precursor 0.0575 0.599 0.599
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0047 0.0361 0.1534
Chlamydia trachomatis DNA gyrase subunit B 0.0032 0.0206 0.064
Trichomonas vaginalis endoplasmin, putative 0.0032 0.0206 0.076
Leishmania major protein kinase, putative 0.0026 0.014 0.0154
Plasmodium falciparum phd finger protein, putative 0.0033 0.0213 0.2612
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0331 0.1223
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0235 0.2369 0.3953
Leishmania major heat shock protein 83-1 0.0032 0.0206 0.0267
Echinococcus granulosus zinc finger protein 0.0027 0.0157 0.026
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0025 0.0134 0.0492
Trypanosoma brucei Heat shock protein 83, putative 0.0032 0.0206 0.0267
Onchocerca volvulus Alhambra homolog 0.0033 0.0213 0.0212
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0057 0.0475 0.3274
Loa Loa (eye worm) hypothetical protein 0.0033 0.0213 0.0212
Trypanosoma brucei heat shock protein, putative 0.0032 0.0206 0.0267
Schistosoma mansoni lamin 0.003 0.0187 0.031
Loa Loa (eye worm) endoplasmin 0.0032 0.0206 0.0205
Mycobacterium ulcerans DNA gyrase subunit B 0.0032 0.0206 0.0173
Echinococcus multilocularis heat shock protein 90 0.0032 0.0206 0.0342
Loa Loa (eye worm) hypothetical protein 0.0056 0.0461 0.046
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.021 0.2105 0.3513
Plasmodium vivax biotin--[acetyl-CoA-carboxylase] synthetase, putative 0.0089 0.0815 1
Brugia malayi PHD-finger family protein 0.0033 0.0213 0.0212
Onchocerca volvulus 0.0025 0.0134 0.0133
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0041 0.0306 0.0437
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0061 0.0513 0.0511
Loa Loa (eye worm) hypothetical protein 0.0061 0.0513 0.0511
Toxoplasma gondii PHD-finger domain-containing protein 0.0033 0.0213 0.0901
Echinococcus granulosus N terminal of biotin protein ligase 0.0122 0.116 0.1935
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0038 0.0036
Entamoeba histolytica hypothetical protein, conserved 0.0122 0.116 0.5501
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.0032 0.0206 0.178
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0229 0.0379
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0061 0.0513 0.0853
Toxoplasma gondii DNA topoisomerase 2, putative 0.0032 0.0206 0.0873
Trypanosoma brucei heat shock protein, putative 0.0032 0.0206 0.0267
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0057 0.0473 0.0715
Brugia malayi SET domain containing protein 0.0015 0.0022 0.0021
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0041 0.0306 0.2441
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0032 0.0206 0.0267
Trichomonas vaginalis heat shock protein, putative 0.0032 0.0206 0.076
Plasmodium vivax hypothetical protein, conserved 0.0032 0.0206 0.253
Mycobacterium tuberculosis Conserved protein 0.0032 0.0206 0.0161
Onchocerca volvulus Putative lipoyltransferase 2, mitochondrial 0.0026 0.0141 0.014
Onchocerca volvulus 0.0013 0.0001 0.000000014899
Echinococcus multilocularis lamin dm0 0.003 0.0187 0.031
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0041 0.0306 0.1444
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0134 0.0492
Schistosoma mansoni cpg binding protein 0.0032 0.0208 0.0344
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.021 0.2108 0.3467
Brugia malayi jmjC domain containing protein 0.0043 0.0328 0.0327
Echinococcus multilocularis biotin protein ligase 0.0089 0.0815 0.1359
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0032 0.0206 0.0173
Mycobacterium leprae POSSIBLE BIFUNCTIONAL PROTEIN BirA: BIOTIN OPERON REPRESSOR + BIOTIN--[ACETYL-COA-CARBOXYLASE] SYNTHETASE (BIOTIN--PROTEIN LIGAS 0.0063 0.054 1
Brugia malayi Bromodomain containing protein 0.0089 0.0818 0.0816
Leishmania major mitochondrial DNA topoisomerase II 0.0032 0.0206 0.0267
Schistosoma mansoni nardilysin (M16 family) 0.0027 0.0151 0.025
Schistosoma mansoni biotin-protein ligase 0.0089 0.0815 0.1359
Plasmodium vivax DNA gyrase subunit B, putative 0.0032 0.0206 0.253
Giardia lamblia PHD finger protein 15 0.0033 0.0213 0.0109
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0107 0.1003 0.1673
Trypanosoma cruzi heat shock protein 90, putative 0.0032 0.0206 0.0267
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0014 0.002 0.0031
Schistosoma mansoni myelin transcription factor 1 myt1 0.0061 0.0513 0.0853
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0032 0.0206 0.0161
Schistosoma mansoni cpg binding protein 0.0036 0.025 0.0415
Echinococcus granulosus 5'partial|biotin protein ligase 0.0063 0.054 0.0899
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0079 0.0288
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0575 0.599 1
Giardia lamblia Kinase, CMGC MAPK 0.0057 0.0473 0.4374
Leishmania major developmentally regulated phosphoprotein-like protein 0.0575 0.599 1
Trypanosoma brucei heat shock protein, putative 0.0032 0.0206 0.0267
Plasmodium vivax hypothetical protein, conserved 0.0033 0.0213 0.2612
Entamoeba histolytica hypothetical protein, conserved 0.0122 0.116 0.5501
Loa Loa (eye worm) hypothetical protein 0.0063 0.054 0.0538
Leishmania major heat shock protein 83-1 0.0032 0.0206 0.0267
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.0473 0.1749
Entamoeba histolytica acetyltransferase, GNAT family 0.004 0.0294 0.1389
Brugia malayi Endoplasmin precursor 0.0032 0.0206 0.0205
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0032 0.0206 0.0205
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0017 0.0044 0.0071
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0134 0.0492
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0025 0.0134 0.0492
Schistosoma mansoni cpg binding protein 0.0036 0.025 0.0415
Loa Loa (eye worm) hypoxia-induced factor 1 0.03 0.3063 0.3062
Leishmania major DNA topoisomerase ii 0.0032 0.0206 0.0267
Trypanosoma cruzi heat shock protein 90, putative 0.0032 0.0206 0.0267
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.0032 0.0206 0.076
Plasmodium falciparum DNA gyrase subunit B 0.0032 0.0206 0.253
Brugia malayi hypoxia-induced factor 1 0.03 0.3063 0.3062
Onchocerca volvulus 0.0072 0.063 0.0629
Loa Loa (eye worm) hypothetical protein 0.0014 0.0015 0.0013
Echinococcus granulosus octanoyltransferase mitochondrial 0.0026 0.0141 0.0233
Schistosoma mansoni bromodomain containing protein 0.0076 0.0678 0.113
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0134 0.0492
Echinococcus multilocularis geminin 0.0189 0.1884 0.3144
Echinococcus multilocularis Protein lozenge 0.0119 0.1137 0.1896
Loa Loa (eye worm) MH2 domain-containing protein 0.0124 0.119 0.1189
Echinococcus granulosus intermediate filament protein 0.003 0.0187 0.031
Echinococcus multilocularis PHD finger protein rhinoceros 0.0033 0.0213 0.0353
Trypanosoma cruzi lipoyltransferase, putative 0.0026 0.0141 0.0157
Echinococcus granulosus lysine specific demethylase 5A 0.0043 0.0328 0.0546
Toxoplasma gondii pyruvate dehydrogenase kinase, putative 0.0201 0.2007 0.8548
Loa Loa (eye worm) hypothetical protein 0.0032 0.0206 0.0205
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0032 0.0206 0.0161
Echinococcus multilocularis N terminal of biotin protein ligase 0.0122 0.116 0.1935
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0032 0.0206 0.0173
Schistosoma mansoni hypothetical protein 0.0189 0.1884 0.3144
Trichomonas vaginalis adenylate cyclase, putative 0.0025 0.0134 0.0492
Schistosoma mansoni lozenge 0.0119 0.1137 0.1896
Loa Loa (eye worm) hypothetical protein 0.0063 0.054 0.0538
Brugia malayi mbt repeat family protein 0.0053 0.0434 0.0433
Echinococcus granulosus geminin 0.0189 0.1884 0.3144
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0025 0.0134 0.0221
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0032 0.0206 0.0873
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0032 0.0206 0.0267
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0041 0.0306 0.1129
Leishmania major heat shock protein 83-1 0.0032 0.0206 0.0267
Loa Loa (eye worm) hypothetical protein 0.0025 0.0134 0.0133
Echinococcus multilocularis tyrosine protein kinase Abl 0.0096 0.0886 0.1477
Schistosoma mansoni endoplasmin 0.0032 0.0206 0.0342
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0306 0.0434
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0025 0.0134 0.0145
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0053 0.0432 0.0719
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0032 0.0206 0.0342
Loa Loa (eye worm) hypothetical protein 0.0575 0.599 0.599
Mycobacterium leprae Probable two-component sensor kinase 0.0032 0.0206 0.178
Plasmodium vivax hypothetical protein, conserved 0.0013 0.0001 0.0018
Echinococcus granulosus heat shock protein 90 0.0032 0.0206 0.0342
Echinococcus multilocularis nardilysin 0.0027 0.0151 0.025
Loa Loa (eye worm) hypothetical protein 0.0089 0.0815 0.0814
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0019 0.0069 0.0112
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0233 0.2347 1
Leishmania major lipoate-protein ligase-like,lipoyl ligase, putative,lipoyltransferase, putative,lipoate biosynthesis protein, putative 0.0026 0.0141 0.0157
Echinococcus granulosus histone acetyltransferase KAT2B 0.0047 0.0361 0.0601
Brugia malayi Tyrosine-protein kinase abl-1 0.0142 0.1383 0.1382
Trypanosoma brucei heat shock protein, putative 0.0032 0.0206 0.0267
Schistosoma mansoni chromobox protein 0.0078 0.0696 0.1159
Toxoplasma gondii PHD-finger domain-containing protein 0.0033 0.0213 0.0901
Loa Loa (eye worm) hypothetical protein 0.0032 0.0206 0.0205
Chlamydia trachomatis insulinase family protease III 0.0027 0.0151 0.0098
Loa Loa (eye worm) hypothetical protein 0.0167 0.1645 0.1644
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0306 0.0434
Echinococcus granulosus heat shock protein 0.0032 0.0206 0.0342
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0061 0.0513 0.0853
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0044 0.0331 0.0329
Schistosoma mansoni heat shock protein 0.0032 0.0206 0.0342
Echinococcus multilocularis inositol monophosphatase 1 0.0041 0.0306 0.0508
Echinococcus multilocularis muscleblind protein 0.0167 0.1645 0.2745
Leishmania major protein kinase, putative 0.0026 0.014 0.0154
Echinococcus granulosus dnaJ subfamily B 0.0457 0.4739 0.791
Schistosoma mansoni pyruvate dehydrogenase 0.0575 0.599 1
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0032 0.0206 0.0161
Trypanosoma brucei developmentally regulated phosphoprotein 0.0575 0.599 1
Trypanosoma brucei lipoyltransferase, putative 0.0026 0.0141 0.0157
Echinococcus multilocularis biotin protein ligase 0.0089 0.0815 0.1359
Loa Loa (eye worm) hypothetical protein 0.0053 0.0432 0.0431
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0047 0.0361 0.443
Entamoeba histolytica hypothetical protein, conserved 0.0122 0.116 0.5501
Leishmania major heat shock protein 83-1 0.0032 0.0206 0.0267
Onchocerca volvulus 0.0034 0.023 0.0229
Brugia malayi PHD-finger family protein 0.0015 0.0021 0.002
Mycobacterium ulcerans putative regulatory protein 0.0072 0.063 0.1297
Leishmania major heat shock protein 83-1 0.0032 0.0206 0.0267
Loa Loa (eye worm) CHromoDomain protein family member 0.0017 0.0044 0.0042
Trichomonas vaginalis bromodomain-containing protein, putative 0.0047 0.0361 0.1336
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.0032 0.0206 0.0967
Brugia malayi Inositol-1 0.0041 0.0306 0.0304
Schistosoma mansoni tyrosine kinase 0.0232 0.2333 0.3893
Loa Loa (eye worm) PHD-finger family protein 0.0033 0.0213 0.0212
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0306 0.0434
Leishmania major phosphoglycan beta 1,3 galactosyltransferase 5 0.0027 0.0151 0.0174
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.0154 0.0254
Echinococcus multilocularis aryl hydrocarbon receptor 0.0025 0.0134 0.0221
Onchocerca volvulus 0.0053 0.0434 0.0433
Echinococcus granulosus peregrin 0.0039 0.028 0.0465
Trypanosoma brucei heat shock protein, putative 0.0032 0.0206 0.0267
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0331 0.1223
Echinococcus granulosus insulin degrading enzyme 0.0027 0.0151 0.025
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0025 0.0134 0.0145
Trypanosoma brucei heat shock protein 90, putative 0.0032 0.0206 0.0267
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0195 0.0719
Mycobacterium leprae Probable lipoate biosynthesis protein B LipB 0.0026 0.0141 0.0173
Brugia malayi Tyrosine-protein kinase abl-1 0.0096 0.0886 0.0885
Trichomonas vaginalis sensor histidine kinase, putative 0.0032 0.0206 0.076

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.11 uM In vitro inhibitory activity against Pyruvate dehydrogenase kinase by primary enzymatic assay ChEMBL. 10425084
IC50 (binding) = 0.11 uM In vitro inhibitory activity against Pyruvate dehydrogenase kinase by primary enzymatic assay ChEMBL. 10425084

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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