Detailed information for compound 1537173

Basic information

Technical information
  • TDR Targets ID: 1537173
  • Name: 2-amino-1-(4-methoxyphenyl)-4-[4-(morpholin-4 -ylmethyl)thiophen-2-yl]-5-oxo-4,6,7,8-tetrah ydroquinoline-3-carbonitrile
  • MW: 476.591 | Formula: C26H28N4O3S
  • H donors: 1 H acceptors: 2 LogP: 2.85 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)N1C(=C(C#N)C(C2=C1CCCC2=O)c1scc(c1)CN1CCOCC1)N
  • InChi: 1S/C26H28N4O3S/c1-32-19-7-5-18(6-8-19)30-21-3-2-4-22(31)25(21)24(20(14-27)26(30)28)23-13-17(16-34-23)15-29-9-11-33-12-10-29/h5-8,13,16,24H,2-4,9-12,15,28H2,1H3
  • InChiKey: BOYFRFKACMMVRU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-amino-1-(4-methoxyphenyl)-4-[4-(morpholinomethyl)-2-thienyl]-5-oxo-4,6,7,8-tetrahydroquinoline-3-carbonitrile
  • 2-amino-5-keto-1-(4-methoxyphenyl)-4-[4-(morpholinomethyl)-2-thienyl]-4,6,7,8-tetrahydroquinoline-3-carbonitrile
  • NCGC00141999-01
  • A3774/0160156

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni tubulin subunit alpha 0.2461 0.7496 0.7494
Toxoplasma gondii alpha tubulin TUBA1 0.2461 0.7496 0.7494
Onchocerca volvulus 0.005 0.0105 0.0323
Leishmania major beta tubulin 0.3278 1 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0039 0.0071 0.0063
Trypanosoma cruzi tubulin gamma chain 0.2009 0.6111 0.6108
Brugia malayi beta-tubulin, identical 0.3278 1 1
Trypanosoma brucei epsilon tubulin 0.2007 0.6104 0.61
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0039 0.0071 0.0071
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0034 0.0057 0.0037
Onchocerca volvulus 0.0092 0.0234 0.0754
Loa Loa (eye worm) beta-tubulin 0.3278 1 1
Echinococcus granulosus lysine specific demethylase 5A 0.0107 0.028 0.0272
Giardia lamblia Beta tubulin 0.3278 1 1
Brugia malayi Nuclear hormone receptor E75 0.0018 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0039 0.0071 0.0063
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.014 0.0382 0.0382
Echinococcus granulosus peroxisome assembly protein 26 0.2461 0.7496 0.7494
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.004 0.0075 0.0066
Trichomonas vaginalis tubulin beta chain, putative 0.0996 0.3006 0.2992
Loa Loa (eye worm) hypothetical protein 0.005 0.0105 0.0097
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0057 0.0037
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0029 0.004 0.0031
Loa Loa (eye worm) tubulin beta-1 chain 0.3278 1 1
Brugia malayi tubulin alpha-2 chain 0.2461 0.7496 0.7496
Echinococcus multilocularis chromobox protein 2 0.0034 0.0057 0.0049
Loa Loa (eye worm) BEN-1 protein 0.3278 1 1
Plasmodium vivax tubulin alpha chain, putative 0.2461 0.7496 0.7491
Schistosoma mansoni hypothetical protein 0.0088 0.0223 0.0215
Brugia malayi MH2 domain containing protein 0.0125 0.0335 0.0335
Brugia malayi nuclear receptor RXR 0.0021 0.0015 0.0015
Schistosoma mansoni voltage-gated potassium channel 0.0043 0.0086 0.0077
Leishmania major alpha tubulin 0.2461 0.7496 0.7494
Schistosoma mansoni RAR-like nuclear receptor 0.0039 0.0071 0.0063
Trichomonas vaginalis tubulin epsilon chain, putative 0.3278 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0039 0.0071 0.0063
Brugia malayi jmjC domain containing protein 0.0029 0.004 0.004
Brugia malayi hypothetical protein 0.0018 0.0009 0.0009
Echinococcus granulosus Tubulin beta 2C chain 0.3278 1 1
Brugia malayi steroid hormone receptor 0.0039 0.0071 0.0071
Echinococcus multilocularis Protein lozenge 0.0058 0.0131 0.0122
Echinococcus multilocularis histone acetyltransferase MYST2 0.0057 0.0126 0.0118
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0029 0.004 0.0031
Loa Loa (eye worm) tubulin beta chain 0.3278 1 1
Echinococcus granulosus tubulin subunit beta 0.3278 1 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0034 0.0057 0.0037
Echinococcus multilocularis mitogen activated protein kinase 0.0112 0.0296 0.0288
Entamoeba histolytica tubulin alpha-1 chain 0.2461 0.7496 0.7491
Loa Loa (eye worm) hypothetical protein 0.0152 0.0417 0.0409
Brugia malayi Protein cec-1. 0.0034 0.0057 0.0057
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0996 0.3006 0.2992
Trichomonas vaginalis CMGC family protein kinase 0.0112 0.0296 0.0276
Loa Loa (eye worm) runx1 0.0058 0.0131 0.0122
Plasmodium falciparum alpha tubulin 2 0.2461 0.7496 0.7491
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0034 0.0057 0.0037
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.2461 0.7496 0.7491
Loa Loa (eye worm) hypothetical protein 0.0458 0.1356 0.1349
Trichomonas vaginalis tubulin epsilon chain, putative 0.3278 1 1
Echinococcus granulosus tubulin alpha chain 0.2461 0.7496 0.7494
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.004 0.0075 0.0066
Trypanosoma cruzi epsilon tubulin, putative 0.2007 0.6104 0.61
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0039 0.0071 0.0063
Echinococcus granulosus PHD finger protein rhinoceros 0.0088 0.0223 0.0215
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0039 0.0071 0.0063
Schistosoma mansoni jumonji/arid domain-containing protein 0.0107 0.028 0.0272
Brugia malayi Cytochrome P450 family protein 0.0018 0.0009 0.0009
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0027 0.0007
Brugia malayi bZIP transcription factor family protein 0.0085 0.0212 0.0212
Trichomonas vaginalis chromobox protein, putative 0.0034 0.0057 0.0037
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.002 0.0012
Onchocerca volvulus Alhambra homolog 0.0088 0.0223 0.0717
Loa Loa (eye worm) hypothetical protein 0.0034 0.0057 0.0049
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.014 0.0382 0.0374
Loa Loa (eye worm) hypothetical protein 0.0034 0.0057 0.0049
Schistosoma mansoni jumonji domain containing protein 0.0029 0.004 0.0031
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0039 0.0071 0.0071
Leishmania major beta tubulin 0.3278 1 1
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0038 0.0068 0.0234
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0034 0.0057 0.0037
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0057 0.0037
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0039 0.0071 0.0071
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0057 0.0037
Echinococcus granulosus microtubule associated protein 2 0.0722 0.2164 0.2157
Leishmania major importin beta-1 subunit, putative 0.0024 0.0027 0.0018
Onchocerca volvulus 0.0463 0.1372 0.4548
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0039 0.0071 0.0063
Plasmodium falciparum tubulin beta chain 0.3278 1 1
Brugia malayi hypothetical protein 0.0067 0.0156 0.0156
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0039 0.0071 0.0063
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0034 0.0057 0.0037
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0039 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.0057 0.0126 0.0118
Trypanosoma brucei tubulin gamma chain 0.2009 0.6111 0.6108
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0039 0.0071 0.0063
Trypanosoma brucei beta tubulin 0.3278 1 1
Echinococcus multilocularis tubulin alpha chain 0.2461 0.7496 0.7494
Loa Loa (eye worm) hypothetical protein 0.0034 0.0057 0.0049
Plasmodium vivax hypothetical protein, conserved 0.0034 0.0057 0.0037
Loa Loa (eye worm) tubulin beta-2A chain 0.3278 1 1
Loa Loa (eye worm) CHromoDomain protein family member 0.0034 0.0057 0.0049
Schistosoma mansoni alpha tubulin 0.2461 0.7496 0.7494
Echinococcus granulosus JmjC domain containing protein 4 0.0029 0.004 0.0031
Loa Loa (eye worm) alpha-tubulin 0.2461 0.7496 0.7494
Brugia malayi chromobox protein homolog 3 0.0117 0.0312 0.0312
Mycobacterium tuberculosis Cell division protein FtsZ 0.0843 0.2537 1
Loa Loa (eye worm) hypothetical protein 0.2461 0.7496 0.7494
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.014 0.0382 0.0374
Echinococcus multilocularis chromobox protein 1 0.0209 0.0594 0.0586
Plasmodium vivax hypothetical protein, conserved 0.0088 0.0223 0.0203
Trypanosoma brucei epsilon tubulin 0.184 0.5591 0.5587
Echinococcus granulosus Tubulin alpha 1 chain 0.2461 0.7496 0.7494
Schistosoma mansoni tubulin subunit beta 0.3278 1 1
Onchocerca volvulus 0.0996 0.3006 1
Plasmodium vivax hypothetical protein, conserved 0.0034 0.0057 0.0037
Loa Loa (eye worm) MH2 domain-containing protein 0.0125 0.0335 0.0327
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.002 0.0012
Echinococcus multilocularis ecdysone induced protein 78C 0.0039 0.0071 0.0063
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.005 0.0105 0.0323
Brugia malayi conserved hypotetical protein 0.0018 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0039 0.0071 0.0063
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.014 0.0382 0.0374
Leishmania major alpha tubulin 0.2461 0.7496 0.7494
Brugia malayi Importin beta-1 subunit 0.003 0.0045 0.0045
Trichomonas vaginalis tubulin epsilon chain, putative 0.0843 0.2537 0.2522
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0034 0.0057 0.0037
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0039 0.0071 0.0071
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0197 0.0555 0.0547
Trichomonas vaginalis Heterochromatin protein, putative 0.0034 0.0057 0.0037
Brugia malayi ecdysteroid receptor 0.0039 0.0071 0.0071
Echinococcus multilocularis Chromobox protein 3 0.0034 0.0057 0.0049
Brugia malayi M-phase phosphoprotein, mpp8 0.0034 0.0057 0.0057
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0021 0.0015 0.0007
Echinococcus granulosus FTZ F1 alpha 0.0039 0.0071 0.0063
Plasmodium falciparum tubulin gamma chain 0.2009 0.6111 0.6104
Echinococcus multilocularis peregrin 0.0088 0.0223 0.0215
Echinococcus granulosus snurportin 1 0.0322 0.0939 0.0931
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0039 0.0071 0.0063
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0029 0.0041 0.0021
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0039 0.0071 0.0063
Trichomonas vaginalis tubulin alpha chain, putative 0.184 0.5591 0.5582
Treponema pallidum cell division protein FtsZ 0.0843 0.2537 0.5
Echinococcus granulosus lysine specific demethylase 6a 0.0029 0.004 0.0031
Onchocerca volvulus 0.0067 0.0156 0.0493
Echinococcus granulosus beta tubulin 0.3278 1 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0183 0.0512 0.0504
Echinococcus multilocularis Chromo domain 0.0034 0.0057 0.0049
Echinococcus multilocularis hypothetical protein 0.2461 0.7496 0.7494
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0039 0.0071 0.0063
Leishmania major beta tubulin 0.3278 1 1
Echinococcus multilocularis jumonji domain containing 1A 0.0029 0.004 0.0031
Echinococcus granulosus peregrin 0.0088 0.0223 0.0215
Trichomonas vaginalis tubulin beta chain, putative 0.2461 0.7496 0.7491
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0034 0.0057 0.0049
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0057 0.0037
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0112 0.0296 0.0288
Echinococcus granulosus tubulin alpha 3 chain 0.2461 0.7496 0.7494
Echinococcus multilocularis tubulin subunit TubB 0.2461 0.7496 0.7494
Trypanosoma cruzi zeta tubulin, putative 0.2597 0.7912 0.791
Schistosoma mansoni hypothetical protein 0.0034 0.0057 0.0049
Echinococcus granulosus alpha tubulin 0.2461 0.7496 0.7494
Echinococcus granulosus muscleblind protein 0.0458 0.1356 0.1349
Onchocerca volvulus Bile acid receptor homolog 0.0039 0.0071 0.021
Leishmania major beta tubulin 0.3278 1 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.0057 0.0049
Loa Loa (eye worm) hypothetical protein 0.0039 0.0071 0.0063
Trichomonas vaginalis chromobox protein, putative 0.0126 0.034 0.032
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0126 0.0337 0.0329
Loa Loa (eye worm) PHD-finger family protein 0.0088 0.0223 0.0215
Trichomonas vaginalis tubulin epsilon chain, putative 0.2461 0.7496 0.7491
Schistosoma mansoni tubulin subunit gamma 0.2009 0.6111 0.6108
Schistosoma mansoni tubulin subunit delta 0.0843 0.2537 0.2531
Brugia malayi photoreceptor-specific nuclear receptor 0.0039 0.0071 0.0071
Schistosoma mansoni sex comb on midleg homolog 0.005 0.0105 0.0097
Echinococcus granulosus tubulin alpha 1C chain 0.2461 0.7496 0.7494
Brugia malayi mbt repeat family protein 0.005 0.0105 0.0105
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0085 0.0212 0.0204
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.005 0.0105 0.0097
Schistosoma mansoni tubulin subunit beta 0.3278 1 1
Brugia malayi Tubulin alpha-2 chain 0.2461 0.7496 0.7496
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.002 0.002
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0029 0.004 0.0031
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0034 0.0057 0.0037
Loa Loa (eye worm) jmjC domain-containing protein 0.0029 0.004 0.0031
Schistosoma mansoni lozenge 0.0058 0.0131 0.0122
Schistosoma mansoni jumonji/arid domain-containing protein 0.0107 0.028 0.0272
Trichomonas vaginalis tubulin gamma chain, putative 0.2007 0.6104 0.6096
Echinococcus multilocularis transcription factor Dp 1 0.0081 0.0201 0.0193
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0034 0.0057 0.0037
Echinococcus granulosus tubulin alpha chain 0.2461 0.7496 0.7494
Echinococcus granulosus Tubulin alpha 1 chain 0.2461 0.7496 0.7494
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0112 0.0296 0.0288
Echinococcus granulosus ecdysone induced protein 78C 0.0039 0.0071 0.0063
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0034 0.0057 0.0049
Echinococcus granulosus histone acetyltransferase MYST2 0.0057 0.0126 0.0118
Brugia malayi SET domain containing protein 0.0034 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.0019 0.0012 0.0003
Echinococcus granulosus jumonji domain containing 1A 0.0029 0.004 0.0031
Echinococcus multilocularis lysine specific demethylase 6a 0.0029 0.004 0.0031
Echinococcus multilocularis tubulin alpha chain 0.2461 0.7496 0.7494
Echinococcus granulosus jun protein 0.0085 0.0212 0.0204
Echinococcus multilocularis polycomb protein SCMH1 0.005 0.0105 0.0097
Echinococcus multilocularis microtubule associated protein 2 0.0722 0.2164 0.2157
Trichomonas vaginalis tubulin alpha chain, putative 0.0996 0.3006 0.2992
Echinococcus multilocularis tubulin epsilon chain 0.2007 0.6104 0.61
Toxoplasma gondii beta tubulin 0.3278 1 1
Trichomonas vaginalis CMGC family protein kinase 0.0112 0.0296 0.0276
Onchocerca volvulus 0.0034 0.0057 0.0163
Echinococcus granulosus Tubulin beta 2C chain 0.3278 1 1
Echinococcus granulosus transcription factor Dp 1 0.0081 0.0201 0.0193
Loa Loa (eye worm) cytochrome P450 family protein 0.0038 0.0068 0.006
Echinococcus multilocularis tubulin alpha 1C chain 0.2461 0.7496 0.7494
Trichomonas vaginalis chromobox protein, putative 0.0034 0.0057 0.0037
Leishmania major beta tubulin 0.3278 1 1
Schistosoma mansoni jun-related protein 0.0069 0.0163 0.0155
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0039 0.0071 0.0063
Echinococcus granulosus chromobox protein 2 0.0034 0.0057 0.0049
Echinococcus granulosus tubulin alpha chain 0.2461 0.7496 0.7494
Echinococcus multilocularis tubulin gamma 1 chain 0.2009 0.6111 0.6108
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0045 0.0036
Leishmania major epsilon tubulin, putative 0.2007 0.6104 0.61
Brugia malayi hypothetical protein 0.0034 0.0058 0.0058
Brugia malayi nuclear hormone receptor family member nhr-6 0.0018 0.0009 0.0009
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0057 0.0126 0.0118
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0039 0.0071 0.0071
Leishmania major beta tubulin 0.3278 1 1
Trichomonas vaginalis tubulin beta chain, putative 0.2461 0.7496 0.7491
Toxoplasma gondii alpha-tubulin I, putative 0.2461 0.7496 0.7494
Brugia malayi Tubulin alpha chain 0.2461 0.7496 0.7496
Loa Loa (eye worm) hypothetical protein 0.0039 0.0071 0.0063
Trypanosoma brucei zeta tubulin 0.2597 0.7912 0.791
Brugia malayi Associated with TFs and helicases family protein 0.0034 0.0057 0.0057
Brugia malayi MAP kinase sur-1 0.0112 0.0296 0.0296
Echinococcus multilocularis tubulin alpha chain 0.2461 0.7496 0.7494
Echinococcus granulosus tubulin epsilon chain 0.2007 0.6104 0.61
Plasmodium falciparum importin beta, putative 0.003 0.0045 0.0024
Trypanosoma brucei alpha tubulin, putative 0.0996 0.3006 0.3
Schistosoma mansoni hypothetical protein 0.0303 0.0882 0.0874
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0034 0.0057 0.0037
Echinococcus granulosus chromobox protein 1 0.0209 0.0594 0.0586
Trichomonas vaginalis chromobox protein, putative 0.0209 0.0594 0.0575
Trichomonas vaginalis tubulin, putative 0.0996 0.3006 0.2992
Trypanosoma cruzi cytochrome P450, putative 0.0038 0.0068 0.0059
Giardia lamblia Kinase, CMGC MAPK 0.0112 0.0296 0.0276
Schistosoma mansoni phosphatidylserine receptor 0.0029 0.004 0.0031
Schistosoma mansoni phd/f-box containing protein 0.0029 0.004 0.0031
Plasmodium vivax heterochromatin protein 1, putative 0.0034 0.0057 0.0037
Leishmania major beta tubulin 0.3278 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0083 0.0207 0.0187
Echinococcus granulosus tubulin alpha 1C chain 0.2461 0.7496 0.7494
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0039 0.0071 0.0071
Loa Loa (eye worm) follicle stimulating hormone receptor 0.025 0.0719 0.0711
Loa Loa (eye worm) tubulin alpha chain 0.2461 0.7496 0.7494
Leishmania major beta tubulin 0.3278 1 1
Schistosoma mansoni chromobox protein 0.0209 0.0594 0.0586
Brugia malayi jmjC domain containing protein 0.0029 0.004 0.004
Loa Loa (eye worm) tubulin alpha chain 0.2461 0.7496 0.7494
Plasmodium falciparum tubulin delta chain, putative 0.0843 0.2537 0.2522
Schistosoma mansoni tubulin subunit alpha 0.0843 0.2537 0.2531
Leishmania major GTP-binding protein, putative 0.0022 0.002 0.0012
Echinococcus multilocularis FTZ F1 alpha 0.0039 0.0071 0.0063
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0039 0.0071 0.0063
Echinococcus granulosus mitogen activated protein kinase 3 0.0112 0.0296 0.0288
Brugia malayi Tubulin beta chain 0.0996 0.3006 0.3006
Trichomonas vaginalis tubulin alpha chain, putative 0.0996 0.3006 0.2992
Giardia lamblia PHD finger protein 15 0.0088 0.0223 0.0203
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0039 0.0071 0.0071
Brugia malayi jmjC domain containing protein 0.0029 0.004 0.004
Schistosoma mansoni ran 0.0022 0.002 0.0012
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0034 0.0057 0.0037
Leishmania major beta tubulin 0.3278 1 1
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0034 0.0057 0.0049
Brugia malayi Cell division protein ftsZ 0.0843 0.2537 0.2537
Schistosoma mansoni tubulin subunit beta 0.3278 1 1
Echinococcus granulosus Chromobox protein 3 0.0034 0.0057 0.0049
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.1465 0.4442 0.4431
Plasmodium falciparum tubulin epsilon chain, putative 0.2007 0.6104 0.6096
Plasmodium vivax delta tubulin, putative 0.0843 0.2537 0.2522
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.014 0.0382 0.0374
Echinococcus granulosus importin subunit beta 1 0.003 0.0045 0.0036
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0057 0.0126 0.0118
Loa Loa (eye worm) steroid hormone receptor 0.0039 0.0071 0.0063
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0029 0.004 0.0031
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0039 0.0071 0.0063
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.002 0.0012
Echinococcus multilocularis chromobox protein 1 0.0209 0.0594 0.0586
Trypanosoma cruzi tubulin delta chain 0.1892 0.5752 0.5748
Plasmodium falciparum JmjC domain-containing protein, putative 0.0029 0.004 0.0019
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0039 0.0071 0.0063
Trichomonas vaginalis conserved hypothetical protein 0.0843 0.2537 0.2522
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0039 0.0071 0.0063
Loa Loa (eye worm) hypothetical protein 0.0039 0.0071 0.0063
Trichomonas vaginalis CMGC family protein kinase 0.0112 0.0296 0.0276
Loa Loa (eye worm) BEN-1 protein 0.3278 1 1
Trichomonas vaginalis tubulin beta chain, putative 0.2461 0.7496 0.7491
Schistosoma mansoni protein phosphatase 2C 0.0029 0.004 0.0031
Trypanosoma cruzi zeta tubulin, putative 0.2597 0.7912 0.791
Loa Loa (eye worm) hypothetical protein 0.0092 0.0234 0.0226
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0015 0.0015
Trichomonas vaginalis conserved hypothetical protein 0.0083 0.0207 0.0187
Trypanosoma brucei beta tubulin 0.184 0.5591 0.5587
Echinococcus granulosus Tubulin beta 2C chain 0.3278 1 1
Schistosoma mansoni ran 0.0022 0.002 0.0012
Loa Loa (eye worm) cytochrome P450 family protein 0.0057 0.0126 0.0118
Schistosoma mansoni retinoic acid receptor RXR 0.0039 0.0071 0.0063
Plasmodium vivax tubulin alpha chain, putative 0.2461 0.7496 0.7491
Leishmania major cytochrome p450-like protein 0.0038 0.0068 0.0059
Echinococcus multilocularis Tubulin alpha 1 chain 0.2461 0.7496 0.7494
Echinococcus multilocularis tubulin alpha 3 chain 0.2461 0.7496 0.7494
Loa Loa (eye worm) hypothetical protein 0.0088 0.0223 0.0215
Entamoeba histolytica tubulin family protein 0.3278 1 1
Echinococcus granulosus beta tubulin 0.3278 1 1
Giardia lamblia Alpha-tubulin 0.2461 0.7496 0.7491
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0112 0.0296 0.0288
Trichomonas vaginalis tubulin epsilon chain, putative 0.2461 0.7496 0.7491
Loa Loa (eye worm) tubulin alpha 2 0.1618 0.4911 0.4907
Loa Loa (eye worm) hypothetical protein 0.0029 0.004 0.0031
Leishmania major alpha tubulin 0.2461 0.7496 0.7494
Brugia malayi nuclear hormone receptor family member odr-7 0.0018 0.0009 0.0009
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0029 0.0041 0.0032
Brugia malayi nuclear receptor NHR-67 0.0018 0.0009 0.0009
Plasmodium vivax tubulin gamma chain, putative 0.2009 0.6111 0.6104
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0057 0.0037
Mycobacterium ulcerans cell division protein FtsZ 0.0843 0.2537 1
Trichomonas vaginalis tubulin gamma chain, putative 0.3278 1 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0058 0.0049
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0034 0.0057 0.0049
Brugia malayi Tubulin beta chain 0.0843 0.2537 0.2537
Loa Loa (eye worm) hypothetical protein 0.0463 0.1372 0.1365
Giardia lamblia Beta tubulin 0.3278 1 1
Schistosoma mansoni tubulin subunit beta 0.3278 1 1
Echinococcus granulosus mitogen activated protein kinase 0.0112 0.0296 0.0288
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0034 0.0057 0.0037
Loa Loa (eye worm) MBCTL1 0.0057 0.0126 0.0118
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0039 0.0071 0.0063
Trypanosoma brucei alpha tubulin 0.2461 0.7496 0.7494
Trichomonas vaginalis tubulin alpha chain, putative 0.0996 0.3006 0.2992
Brugia malayi Heterochromatin protein 1 0.0209 0.0594 0.0594
Schistosoma mansoni alpha tubulin 0.2461 0.7496 0.7494
Onchocerca volvulus 0.0034 0.0057 0.0163
Trypanosoma cruzi beta tubulin, putative 0.3278 1 1
Leishmania major alpha tubulin 0.2461 0.7496 0.7494
Echinococcus granulosus tubulin gamma 1 chain 0.2009 0.6111 0.6108
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0126 0.034 0.1104
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0029 0.004 0.0031
Brugia malayi Cytochrome P450 family protein 0.0057 0.0126 0.0126
Echinococcus multilocularis tubulin alpha 0.184 0.5591 0.5587
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0034 0.0057 0.0037
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0015 0.0015
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0112 0.0296 0.0288
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0039 0.0071 0.0063
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0027 0.0007
Leishmania major alpha tubulin 0.2461 0.7496 0.7494
Leishmania major beta tubulin 0.3278 1 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0045 0.0036
Schistosoma mansoni thyroid hormone receptor 0.0164 0.0456 0.0448
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0041 0.0021
Trypanosoma cruzi tubulin delta chain 0.1892 0.5752 0.5748
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0057 0.0037
Loa Loa (eye worm) tubulin beta-4 chain 0.3278 1 1
Loa Loa (eye worm) transcription factor SMAD2 0.0125 0.0335 0.0327
Echinococcus multilocularis SAM and MBT domain containing protein 0.005 0.0105 0.0097
Loa Loa (eye worm) jmjC domain-containing protein 0.0107 0.028 0.0272
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0021 0.0015 0.0007
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0034 0.0057 0.0057
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0057 0.0037
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.014 0.0382 0.0374
Echinococcus multilocularis mitogen activated protein kinase 3 0.0112 0.0296 0.0288
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0088 0.0223 0.0215
Trypanosoma brucei protein kinase, putative 0.0112 0.0296 0.0288
Echinococcus multilocularis Tubulin beta 2C chain 0.3278 1 1
Loa Loa (eye worm) tubulin beta chain 0.0843 0.2537 0.2531
Brugia malayi hypothetical protein 0.0021 0.0015 0.0015
Trichomonas vaginalis chromobox protein, putative 0.0209 0.0594 0.0575
Schistosoma mansoni chromobox protein 0.0034 0.0057 0.0049
Brugia malayi Cytochrome P450 family protein 0.0038 0.0068 0.0068
Trichomonas vaginalis conserved hypothetical protein 0.0117 0.0312 0.0292
Brugia malayi tubulin alpha chain - mouse 0.2461 0.7496 0.7496
Schistosoma mansoni thyroid hormone receptor 0.0164 0.0456 0.0448
Trypanosoma brucei tubulin delta chain 0.1892 0.5752 0.5748
Brugia malayi Tubulin gamma chain 0.2009 0.6111 0.6111
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.1011 0.305 0.3044
Brugia malayi nuclear hormone receptor 0.0018 0.0009 0.0009
Giardia lamblia Beta tubulin 0.3278 1 1
Trichomonas vaginalis tubulin, putative 0.0996 0.3006 0.2992
Brugia malayi PHD-finger family protein 0.0088 0.0223 0.0223
Trypanosoma brucei alpha tubulin 0.2461 0.7496 0.7494
Leishmania major hypothetical protein, conserved 0.0029 0.004 0.0031
Echinococcus multilocularis jun protein 0.0085 0.0212 0.0204
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0015 0.0007
Entamoeba histolytica hypothetical protein 0.0034 0.0057 0.0037
Brugia malayi jmjC domain containing protein 0.029 0.084 0.084
Entamoeba histolytica hypothetical protein 0.0024 0.0027 0.0007
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.014 0.0382 0.0374
Echinococcus multilocularis Tubulin beta 2C chain 0.3278 1 1
Brugia malayi Nuclear hormone receptor-like 1 0.0039 0.0071 0.0071
Schistosoma mansoni coup transcription factor 0.0039 0.0071 0.0063
Echinococcus granulosus Tubulin beta 2C chain 0.3278 1 1
Toxoplasma gondii PHD-finger domain-containing protein 0.0088 0.0223 0.0215
Schistosoma mansoni microtubule-associated protein tau 0.0722 0.2164 0.2157
Trichomonas vaginalis conserved hypothetical protein 0.0117 0.0312 0.0292
Loa Loa (eye worm) hypothetical protein 0.1618 0.4911 0.4907
Trypanosoma brucei alpha tubulin 0.2461 0.7496 0.7494
Loa Loa (eye worm) tubulin alpha-3 chain 0.1465 0.4442 0.4437
Echinococcus multilocularis tubulin alpha chain 0.2461 0.7496 0.7494
Trichomonas vaginalis conserved hypothetical protein 0.0843 0.2537 0.2522
Onchocerca volvulus Protein ultraspiracle homolog 0.0039 0.0071 0.021
Echinococcus multilocularis Tubulin beta 2C chain 0.3278 1 1
Echinococcus multilocularis Tubulin alpha 1 chain 0.2461 0.7496 0.7494
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.002 0.0012
Loa Loa (eye worm) tubulin alpha 2 0.0622 0.1857 0.185
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0034 0.0057 0.0049
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0085 0.0212 0.0204
Schistosoma mansoni sex comb on midleg homolog 0.005 0.0105 0.0097
Loa Loa (eye worm) hypothetical protein 0.0034 0.0057 0.0049
Schistosoma mansoni hypothetical protein 0.0322 0.0939 0.0931
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0197 0.0555 0.0547
Echinococcus multilocularis PHD finger protein rhinoceros 0.0088 0.0223 0.0215
Trypanosoma cruzi epsilon tubulin, putative 0.2007 0.6104 0.61
Trypanosoma cruzi alpha tubulin, putative 0.2461 0.7496 0.7494
Brugia malayi F/Y-rich N-terminus family protein 0.0029 0.0041 0.0041
Trypanosoma brucei alpha tubulin 0.2461 0.7496 0.7494
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0039 0.0071 0.021
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0039 0.0071 0.0071
Schistosoma mansoni tubulin subunit epsilon 0.2007 0.6104 0.61
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0039 0.0071 0.0071
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0037 0.0066 0.0046
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.002 0.0012
Trichomonas vaginalis hypothetical protein 0.0034 0.0057 0.0037
Plasmodium vivax JmjC domain containing protein 0.0029 0.004 0.0019
Loa Loa (eye worm) tubulin gamma chain 0.2009 0.6111 0.6108
Echinococcus granulosus tubulin alpha 0.184 0.5591 0.5587
Onchocerca volvulus 0.0039 0.0071 0.021
Schistosoma mansoni tubulin subunit beta 0.3278 1 1
Brugia malayi alpha-tubulin 0.2461 0.7496 0.7496
Echinococcus granulosus tubulin alpha 3 chain 0.2461 0.7496 0.7494
Trypanosoma brucei zeta tubulin, putative 0.2597 0.7912 0.791
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0039 0.0071 0.0063
Mycobacterium leprae cell division protein FtsZ 0.0843 0.2537 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0039 0.0071 0.0063
Leishmania major gamma-tubulin 0.2009 0.6111 0.6108
Trichomonas vaginalis chromobox protein, putative 0.0126 0.034 0.032
Schistosoma mansoni hypothetical protein 0.0069 0.0163 0.0155
Loa Loa (eye worm) heterochromatin protein 1 0.0209 0.0594 0.0586
Brugia malayi nuclear receptor NHR-88 0.0039 0.0071 0.0071
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.002 0.0012
Brugia malayi tailless protein 0.0018 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0029 0.0041 0.0032
Loa Loa (eye worm) alpha-tubulin 0.2461 0.7496 0.7494
Brugia malayi cytochrome P450 0.0018 0.0009 0.0009
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0034 0.0057 0.0037
Loa Loa (eye worm) jmjC domain-containing protein 0.0029 0.004 0.0031
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.002 0.0012
Giardia lamblia Delta tubulin 0.0843 0.2537 0.2522
Entamoeba histolytica tubulin gamma chain 0.2009 0.6111 0.6104
Loa Loa (eye worm) hypothetical protein 0.0039 0.0071 0.0063
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0039 0.0071 0.0063
Trypanosoma brucei beta tubulin 0.3278 1 1
Entamoeba histolytica hypothetical protein 0.0034 0.0057 0.0037
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0021 0.0015 0.0007
Echinococcus multilocularis muscleblind protein 0.0458 0.1356 0.1349
Brugia malayi Muscleblind-like protein 0.0458 0.1356 0.1356
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.014 0.0382 0.0363
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0112 0.0296 0.0288
Brugia malayi orphan nuclear receptor NR2E1 0.0018 0.0009 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0057 0.0037
Leishmania major beta tubulin 0.3278 1 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0015 0.0007
Trichomonas vaginalis tubulin, putative 0.3278 1 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.029 0.084 0.0832
Leishmania major delta tubulin, putative 0.1892 0.5752 0.5748
Echinococcus multilocularis Tubulin beta 2C chain 0.3278 1 1
Echinococcus granulosus Tubulin beta 2C chain 0.3278 1 1
Loa Loa (eye worm) tubulin alpha 2 0.1618 0.4911 0.4907
Loa Loa (eye worm) jmjC domain-containing protein 0.0029 0.004 0.0031
Giardia lamblia Gamma tubulin 0.2009 0.6111 0.6104
Leishmania major beta tubulin 0.3278 1 1
Loa Loa (eye worm) hypothetical protein 0.1465 0.4442 0.4437
Brugia malayi Valyl-tRNA synthetase 0.0034 0.0057 0.0057
Echinococcus multilocularis tubulin beta 1 chain 0.3278 1 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0039 0.0071 0.0063
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0034 0.0057 0.0049
Trichomonas vaginalis tubulin, putative 0.1013 0.3058 0.3043
Echinococcus granulosus nuclear factor of activated T cells 5 0.0074 0.018 0.0172
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.184 0.5591 0.5587
Leishmania major beta tubulin 0.3278 1 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0034 0.0057 0.0037
Loa Loa (eye worm) hypothetical protein 0.0021 0.0015 0.0007
Echinococcus granulosus Tubulin alpha 1 chain 0.2461 0.7496 0.7494
Brugia malayi CHD4 protein 0.0034 0.0057 0.0057
Trypanosoma brucei epsilon tubulin 0.2007 0.6104 0.61
Echinococcus multilocularis tubulin subunit beta 0.3278 1 1
Schistosoma mansoni tubulin subunit alpha 0.2461 0.7496 0.7494
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0039 0.0071 0.0063
Brugia malayi nuclear receptor NHR-88 0.0018 0.0009 0.0009
Trypanosoma cruzi cytochrome P450, putative 0.0038 0.0068 0.0059
Echinococcus granulosus tubulin subunit TubB 0.2461 0.7496 0.7494
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0074 0.018 0.0172
Schistosoma mansoni jumonji domain containing protein 0.023 0.0658 0.065
Brugia malayi follicle stimulating hormone receptor 0.025 0.0719 0.0719
Trypanosoma brucei cytochrome P450, putative 0.0038 0.0068 0.0059
Schistosoma mansoni hypothetical protein 0.0126 0.0337 0.0329
Loa Loa (eye worm) hypothetical protein 0.0021 0.0015 0.0007
Echinococcus granulosus tubulin beta 1 chain 0.3278 1 1
Schistosoma mansoni voltage-gated potassium channel 0.0043 0.0086 0.0077
Echinococcus multilocularis muscleblind protein 1 0.0458 0.1356 0.1349
Loa Loa (eye worm) helicase 0.0034 0.0057 0.0049
Leishmania major alpha tubulin 0.2461 0.7496 0.7494
Brugia malayi hypothetical protein 0.0463 0.1372 0.1372
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0843 0.2537 0.5
Loa Loa (eye worm) CYP4Cod1 0.0038 0.0068 0.006
Schistosoma mansoni alpha tubulin 0.2461 0.7496 0.7494
Schistosoma mansoni tubulin subunit beta 0.3278 1 1
Echinococcus multilocularis jumonji domain containing protein 0.0123 0.033 0.0321
Leishmania major alpha tubulin 0.2461 0.7496 0.7494
Trichomonas vaginalis tubulin gamma chain, putative 0.2009 0.6111 0.6104
Echinococcus multilocularis beta tubulin 0.3278 1 1
Brugia malayi Cytochrome P450 family protein 0.0038 0.0068 0.0068
Plasmodium vivax importin-beta 2, putative 0.003 0.0045 0.0024
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0039 0.0071 0.0071
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.014 0.0382 0.0374
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0034 0.0057 0.0037
Toxoplasma gondii tubulin, putative 0.0167 0.0465 0.0457
Brugia malayi Steroid receptor seven-up type 2 0.0039 0.0071 0.0071
Plasmodium falciparum heterochromatin protein 1 0.0034 0.0057 0.0037
Echinococcus multilocularis lysine specific demethylase 5A 0.0107 0.028 0.0272
Brugia malayi Nuclear hormone receptor E75 0.0018 0.0009 0.0009
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0112 0.0296 0.0288
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0034 0.0057 0.0037
Brugia malayi AF-10 protein 0.0029 0.0041 0.0041
Echinococcus granulosus chromobox protein 1 0.0209 0.0594 0.0586
Brugia malayi PHD-finger family protein 0.0029 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0463 0.1372 0.1365
Echinococcus multilocularis importin subunit beta 1 0.003 0.0045 0.0036
Loa Loa (eye worm) hypothetical protein 0.0021 0.0015 0.0007
Echinococcus multilocularis tubulin alpha 1C chain 0.2461 0.7496 0.7494
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0034 0.0057 0.0037
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0029 0.004 0.0031
Echinococcus multilocularis tubulin, beta 4A class IVa 0.3278 1 1
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0045 0.0036
Echinococcus granulosus Chromo domain 0.0034 0.0057 0.0049
Echinococcus multilocularis tubulin alpha 3 chain 0.2461 0.7496 0.7494
Schistosoma mansoni nuclear hormone receptor 0.0039 0.0071 0.0063
Brugia malayi Tubulin alpha chain 0.0843 0.2537 0.2537
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0112 0.0296 0.0288
Plasmodium vivax tubulin beta chain, putative 0.3278 1 1
Brugia malayi jmjC domain containing protein 0.0029 0.004 0.004
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.1892 0.5752 0.5748
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0034 0.0057 0.0049
Leishmania major beta tubulin 0.3278 1 1
Brugia malayi hypothetical protein 0.0018 0.0009 0.0009
Schistosoma mansoni tubulin subunit beta 0.0843 0.2537 0.2531
Leishmania major alpha tubulin 0.2461 0.7496 0.7494
Echinococcus multilocularis phd:f box containing protein 0.0029 0.004 0.0031
Brugia malayi RNA, U transporter 1 0.0086 0.0215 0.0215
Echinococcus multilocularis Tubulin beta 2C chain 0.3278 1 1
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0034 0.0057 0.0049
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0057 0.0037
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0027 0.0007
Giardia lamblia Alpha-tubulin 0.2461 0.7496 0.7491
Schistosoma mansoni hypothetical protein 0.0029 0.0041 0.0032
Trichomonas vaginalis chromobox protein, putative 0.0034 0.0057 0.0037
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0029 0.004 0.0031
Echinococcus granulosus tubulin alpha chain 0.2461 0.7496 0.7494
Toxoplasma gondii PHD-finger domain-containing protein 0.0088 0.0223 0.0215
Echinococcus multilocularis thyroid hormone receptor alpha 0.0164 0.0456 0.0448
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0112 0.0296 0.0288
Echinococcus multilocularis tubulin alpha chain 0.2461 0.7496 0.7494
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0057 0.0126 0.0126
Loa Loa (eye worm) hypothetical protein 0.0039 0.0071 0.0063
Brugia malayi hypothetical protein 0.0021 0.0015 0.0015
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0018 0.0009 0.0009
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0029 0.0041 0.0032
Trichomonas vaginalis tubulin beta chain, putative 0.2461 0.7496 0.7491
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0045 0.0036
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0034 0.0057 0.0049
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.004 0.0075 0.0075
Entamoeba histolytica tubulin family protein 0.3278 1 1
Toxoplasma gondii beta-1 tubulin, putative 0.3278 1 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0057 0.0049
Echinococcus granulosus jumonji domain containing protein 0.0123 0.033 0.0321
Trypanosoma brucei beta tubulin 0.3278 1 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0037 0.0066 0.0046
Leishmania major alpha tubulin 0.2461 0.7496 0.7494
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0029 0.0041 0.0032
Loa Loa (eye worm) hypothetical protein 0.0021 0.0015 0.0007
Loa Loa (eye worm) alpha-tubulin isotype 2 0.1618 0.4911 0.4907
Echinococcus multilocularis beta tubulin 0.3278 1 1
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0027 0.0018
Echinococcus granulosus phd:f box containing protein 0.0029 0.004 0.0031
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0039 0.0071 0.0063
Leishmania major alpha tubulin 0.2461 0.7496 0.7494
Entamoeba histolytica hypothetical protein 0.0034 0.0057 0.0037
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0039 0.0071 0.0071
Brugia malayi ecdysone receptor 0.0018 0.0009 0.0009
Echinococcus multilocularis snurportin 1 0.0322 0.0939 0.0931
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0039 0.0071 0.0063
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0034 0.0057 0.0049
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0041 0.0032
Plasmodium vivax tubulin epsilon chain, putative 0.2007 0.6104 0.6096
Schistosoma mansoni chromobox protein 0.0209 0.0594 0.0586
Giardia lamblia Epsilon tubulin 0.1011 0.305 0.3036
Schistosoma mansoni chromobox protein 0.0034 0.0057 0.0049
Leishmania major beta tubulin 0.3278 1 1
Echinococcus granulosus polycomb protein SCMH1 0.005 0.0105 0.0097
Brugia malayi Bromodomain containing protein 0.0088 0.0223 0.0223
Loa Loa (eye worm) hypothetical protein 0.0029 0.004 0.0031
Brugia malayi nuclear hormone receptor 0.0039 0.0071 0.0071
Echinococcus granulosus tubulin alpha chain 0.2461 0.7496 0.7494
Trichomonas vaginalis tubulin beta chain, putative 0.2461 0.7496 0.7491
Leishmania major beta tubulin 0.3278 1 1
Trichomonas vaginalis tubulin gamma chain, putative 0.0843 0.2537 0.2522
Brugia malayi nuclear receptor RXR 0.0018 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0458 0.1356 0.1349
Brugia malayi jmjC domain containing protein 0.0107 0.028 0.028
Plasmodium falciparum phd finger protein, putative 0.0088 0.0223 0.0203
Loa Loa (eye worm) hypothetical protein 0.0034 0.0057 0.0049
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0039 0.0071 0.0063
Echinococcus granulosus tubulin delta chain 0.0843 0.2537 0.2531
Echinococcus multilocularis JmjC domain containing protein 4 0.0029 0.004 0.0031
Leishmania major alpha tubulin 0.2461 0.7496 0.7494
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0843 0.2537 0.2522
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0117 0.0312 0.1013
Plasmodium falciparum alpha tubulin 1 0.2461 0.7496 0.7491
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0029 0.004 0.0031
Leishmania major beta tubulin 0.3278 1 1
Echinococcus granulosus tubulin beta 4A class IVa 0.3278 1 1
Echinococcus granulosus SAM and MBT domain containing protein 0.005 0.0105 0.0097
Loa Loa (eye worm) hypothetical protein 0.0117 0.0312 0.0304
Brugia malayi mbt repeat family protein 0.005 0.0105 0.0105
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0126 0.0337 0.0329
Toxoplasma gondii beta-tubulin, putative 0.3278 1 1
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.1618 0.4911 0.4901
Onchocerca volvulus 0.0034 0.0057 0.0163
Loa Loa (eye worm) hypothetical protein 0.0039 0.0071 0.0063
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.029 0.084 0.0832
Leishmania major zeta tubulin, putative 0.2597 0.7912 0.791
Echinococcus multilocularis peroxisome assembly protein 26 0.2461 0.7496 0.7494
Loa Loa (eye worm) hypothetical protein 0.0082 0.0205 0.0197
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0112 0.0296 0.0288
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.014 0.0382 0.0374
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0039 0.0071 0.0071
Trichomonas vaginalis tubulin beta chain, putative 0.3278 1 1
Schistosoma mansoni tubulin subunit alpha 0.2461 0.7496 0.7494
Leishmania major beta tubulin 0.3278 1 1
Echinococcus multilocularis tubulin delta chain 0.0843 0.2537 0.2531
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0039 0.0071 0.0063
Entamoeba histolytica tubulin alpha chain, putative 0.2461 0.7496 0.7491
Loa Loa (eye worm) cytochrome P450 family protein 0.0038 0.0068 0.006
Brugia malayi Tubulin alpha-2 chain 0.2461 0.7496 0.7496
Loa Loa (eye worm) mbt repeat family protein 0.005 0.0105 0.0097
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0021 0.0015 0.0007
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0322 0.0939 0.0931
Trichomonas vaginalis CMGC family protein kinase 0.0112 0.0296 0.0276
Loa Loa (eye worm) hypothetical protein 0.0035 0.0058 0.005
Schistosoma mansoni serine/threonine protein kinase 0.0112 0.0296 0.0288
Trichomonas vaginalis tubulin beta chain, putative 0.2461 0.7496 0.7491
Trichomonas vaginalis tubulin alpha chain, putative 0.3278 1 1
Trypanosoma brucei beta tubulin 0.3278 1 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0034 0.0057 0.0037
Leishmania major alpha tubulin 0.2461 0.7496 0.7494
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0034 0.0057 0.0049
Echinococcus multilocularis Tubulin alpha 1 chain 0.2461 0.7496 0.7494
Schistosoma mansoni importin beta-1 0.003 0.0045 0.0036
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0039 0.0071 0.0063
Echinococcus granulosus potassium voltage gated channel subfamily H 0.004 0.0075 0.0066
Schistosoma mansoni myelin transcription factor 1 myt1 0.0057 0.0126 0.0118
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0029 0.0041 0.0032
Loa Loa (eye worm) tubulin alpha-2 chain 0.2461 0.7496 0.7494

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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