Detailed information for compound 1545615

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 403.684 | Formula: C27H49NO
  • H donors: 1 H acceptors: 0 LogP: 7.66 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CO[C@H]1CC[C@]2(C(C1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2C(NCCC(C)C)C)C)C
  • InChi: 1S/C27H49NO/c1-18(2)13-16-28-19(3)23-9-10-24-22-8-7-20-17-21(29-6)11-14-26(20,4)25(22)12-15-27(23,24)5/h18-25,28H,7-17H2,1-6H3/t19?,20?,21-,22-,23+,24-,25-,26-,27+/m0/s1
  • InChiKey: FPYGMKMGRVHQNZ-ROHAWPQESA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Chlamydia trachomatis glyceraldehyde-3-phosphate dehydrogenase 0.0068 0.019 0.1521
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0108 0.0341 0.2765
Loa Loa (eye worm) hypothetical protein 0.0091 0.0278 0.0302
Onchocerca volvulus Neuropeptide F receptor homolog 0.0055 0.0143 0.115
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.0143 0.0142
Leishmania major heat shock protein 83-1 0.0134 0.0437 0.0607
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.1944 0.7185 0.7867
Entamoeba histolytica hypothetical protein 0.0019 0.0009 0.0062
Loa Loa (eye worm) hypothetical protein 0.0055 0.0143 0.0155
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0009 0.0008
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0055 0.0143 0.0142
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0055 0.0143 0.0155
Mycobacterium leprae probable uridine phosphorylase 0.2466 0.9132 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0041 0.009 0.0088
Trichomonas vaginalis purine nucleoside phosphorylase I, putative 0.0347 0.1232 1
Echinococcus multilocularis serotonin receptor 0.0055 0.0143 0.0142
Echinococcus multilocularis endoplasmin 0.003 0.0048 0.0047
Loa Loa (eye worm) hypothetical protein 0.0055 0.0143 0.0155
Schistosoma mansoni hypothetical protein 0.0281 0.0984 0.1076
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0108 0.0341 0.2744
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0009 0.0011
Echinococcus multilocularis p2X purinoceptor 4 0.0342 0.1211 0.121
Schistosoma mansoni opsin-like receptor 0.0055 0.0143 0.0155
Leishmania major nucleoside phosphorylase-like protein 0.0347 0.1232 0.1714
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0096 0.0296 0.0322
Trypanosoma cruzi heat shock protein 85, putative 0.0134 0.0437 0.0607
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0009 0.0008
Loa Loa (eye worm) TOPoisomerase family member 0.0108 0.0341 0.0372
Loa Loa (eye worm) hypothetical protein 0.0055 0.0143 0.0155
Loa Loa (eye worm) hypothetical protein 0.0055 0.0143 0.0155
Toxoplasma gondii DNA topoisomerase 2, putative 0.0108 0.0341 0.1181
Mycobacterium ulcerans heat shock protein 90 0.003 0.0048 0.0363
Loa Loa (eye worm) hypothetical protein 0.0055 0.0143 0.0155
Loa Loa (eye worm) hypothetical protein 0.0055 0.0143 0.0155
Trypanosoma brucei uridine phosphorylase 0.0347 0.1232 0.1714
Entamoeba histolytica hypothetical protein 0.0041 0.009 0.0717
Onchocerca volvulus 0.0055 0.0143 0.115
Loa Loa (eye worm) isocitrate dehydrogenase 0.0096 0.0296 0.0322
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0347 0.1232 1
Schistosoma mansoni peter pan-related 0.0062 0.0169 0.0184
Onchocerca volvulus 0.0055 0.0143 0.115
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0044 0.0103 0.0112
Schistosoma mansoni pyruvate dehydrogenase 0.1835 0.6782 0.7426
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0091 0.0278 0.2204
Trypanosoma brucei poly(ADP-ribose) glycohydrolase, putative 0.0173 0.0584 0.0811
Entamoeba histolytica hypothetical protein 0.0041 0.009 0.0717
Loa Loa (eye worm) hypothetical protein 0.0044 0.0103 0.0112
Echinococcus multilocularis somatostatin receptor 0.0055 0.0143 0.0142
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.0068 0.019 0.1492
Schistosoma mansoni P2X receptor subunit 0.0342 0.1211 0.1325
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0068 0.019 0.0207
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0055 0.0143 0.0142
Leishmania major DNA topoisomerase ii 0.0108 0.0341 0.0472
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0055 0.0143 0.0155
Trypanosoma cruzi heat shock protein 85, putative 0.0134 0.0437 0.0607
Brugia malayi G-protein coupled receptor 0.0055 0.0143 0.0155
Trypanosoma cruzi DNA topoisomerase II, putative 0.0108 0.0341 0.0472
Echinococcus granulosus methylthioadenosine phosphorylase 0.0347 0.1232 0.1348
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0347 0.1232 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.0143 0.0142
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0026 0.0199
Echinococcus granulosus p2X purinoceptor 4 0.0342 0.1211 0.1325
Schistosoma mansoni hypothetical protein 0.013 0.0422 0.046
Schistosoma mansoni uridine phosphorylase 0.2466 0.9132 1
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0009 0.0008
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0026 0.0001
Schistosoma mansoni P2X receptor subunit 0.0204 0.0697 0.0761
Brugia malayi PXA domain containing protein 0.0019 0.0009 0.0008
Brugia malayi Dopamine receptor 0.0055 0.0143 0.0155
Schistosoma mansoni P2X receptor subunit 0.0204 0.0697 0.0761
Schistosoma mansoni neuropeptide F-like receptor 0.0055 0.0143 0.0155
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0029 0.0044 0.0043
Brugia malayi G-protein coupled receptor 0.0055 0.0143 0.0155
Treponema pallidum purine nucleoside phosphorylase (deoD) 0.0347 0.1232 1
Echinococcus granulosus geminin 0.0359 0.1278 0.1398
Loa Loa (eye worm) hypothetical protein 0.0018 0.0004 0.0002
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.0143 0.0142
Entamoeba histolytica hypothetical protein 0.0041 0.009 0.0717
Brugia malayi hypothetical protein 0.0055 0.0143 0.0155
Toxoplasma gondii brix domain-containing protein 0.0062 0.0169 0.0584
Onchocerca volvulus 0.0055 0.0143 0.115
Brugia malayi kinase, mitochondrial precursor 0.1944 0.7185 0.7867
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0009 0.0008
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH1 0.0068 0.019 0.0658
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0034 0.0215
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.0044 0.0103 0.0779
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0108 0.0341 0.2765
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0009 0.0008
Schistosoma mansoni opsin-like receptor 0.0055 0.0143 0.0155
Trypanosoma brucei heat shock protein, putative 0.0134 0.0437 0.0607
Echinococcus granulosus purine nucleoside phosphorylase 0.0347 0.1232 0.1348
Echinococcus granulosus expressed protein 0.0373 0.1329 0.1454
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0347 0.1232 1
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0009 0.0011
Echinococcus granulosus biogenic amine 5HT receptor 0.0055 0.0143 0.0155
Loa Loa (eye worm) melatonin receptor type 1A 0.0055 0.0143 0.0155
Echinococcus granulosus neuropeptide FF receptor 2 0.0055 0.0143 0.0155
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.003 0.004
Loa Loa (eye worm) hypothetical protein 0.0055 0.0143 0.0155
Onchocerca volvulus 0.0055 0.0143 0.115
Brugia malayi hypothetical protein 0.0019 0.0009 0.0008
Schistosoma mansoni pyruvate dehydrogenase 0.1944 0.7185 0.7867
Onchocerca volvulus 0.0055 0.0143 0.115
Echinococcus granulosus purine nucleoside phosphorylase 0.0347 0.1232 0.1348
Brugia malayi MTAP 0.0347 0.1232 0.1348
Leishmania major heat shock protein 83-1 0.0134 0.0437 0.0607
Mycobacterium tuberculosis Possible two component sensor kinase 0.0108 0.0341 0.2765
Schistosoma mansoni myosin xvIII 0.0055 0.0143 0.0155
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0026 0.0182
Schistosoma mansoni opsin-like receptor 0.0055 0.0143 0.0155
Loa Loa (eye worm) hypothetical protein 0.0989 0.3625 0.3969
Leishmania major developmentally regulated phosphoprotein-like protein 0.1944 0.7185 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0008 0.0009
Trypanosoma brucei heat shock protein, putative 0.0134 0.0437 0.0607
Loa Loa (eye worm) hypothetical protein 0.0055 0.0143 0.0155
Trichomonas vaginalis ssf, putative 0.0062 0.0169 0.1318
Echinococcus granulosus beta-adrenergic receptor kinase 0.0019 0.0009 0.0008
Trypanosoma cruzi peter pan protein, putative 0.0062 0.0169 0.0233
Echinococcus granulosus p2X purinoceptor 4 0.0342 0.1211 0.1325
Brugia malayi neuropeptide F receptor 0.0055 0.0143 0.0155
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0347 0.1232 1
Toxoplasma gondii heat shock protein 90, putative 0.0134 0.0437 0.1517
Brugia malayi Poly 0.0173 0.0584 0.0638
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0108 0.0341 0.2765
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0068 0.019 0.0263
Leishmania major heat shock protein 83-1 0.0134 0.0437 0.0607
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0108 0.0341 0.0339
Brugia malayi Isocitrate dehydrogenase 0.0096 0.0296 0.0322
Echinococcus multilocularis fmrfamide receptor 0.0055 0.0143 0.0142
Loa Loa (eye worm) hypothetical protein 0.1944 0.7185 0.7867
Toxoplasma gondii pyruvate dehydrogenase kinase, putative 0.0679 0.2471 0.8597
Plasmodium falciparum BRIX domain, putative 0.0062 0.0169 0.1362
Echinococcus granulosus alpha 1A adrenergic receptor 0.0055 0.0143 0.0155
Loa Loa (eye worm) hypothetical protein 0.0019 0.0009 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0009 0.0011
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0096 0.0296 0.041
Loa Loa (eye worm) endoplasmin 0.0134 0.0437 0.0477
Brugia malayi glyceraldehyde 3-phosphate dehydrogenase 0.0021 0.0016 0.0016
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.0108 0.0341 0.2744
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0068 0.019 0.0263
Echinococcus multilocularis heat shock protein 90 0.0134 0.0437 0.0436
Echinococcus granulosus hypothetical protein 0.0055 0.0143 0.0155
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.0143 0.0142
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.0143 0.0155
Schistosoma mansoni transcription factor LCR-F1 0.0041 0.009 0.0097
Leishmania major heat shock protein 83-1 0.0134 0.0437 0.0607
Loa Loa (eye worm) hypothetical protein 0.0055 0.0143 0.0155
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0023 0.0025 0.014
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0347 0.1232 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0059 0.0158 0.0172
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0009 0.0008
Schistosoma mansoni neuropeptide receptor 0.0055 0.0143 0.0155
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0068 0.019 0.0263
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0108 0.0341 0.2757
Leishmania major heat shock protein 83-1 0.0134 0.0437 0.0607
Echinococcus granulosus peter pan 0.0062 0.0169 0.0184
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0068 0.019 0.0207
Schistosoma mansoni endoplasmin 0.0134 0.0437 0.0477
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0108 0.0341 0.0372
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.0143 0.0155
Echinococcus granulosus endoplasmin 0.003 0.0048 0.0051
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0008 0.0009
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0008 0.0051
Mycobacterium ulcerans 5'-methylthioadenosine phosphorylase 0.0347 0.1232 1
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0055 0.0143 0.0155
Schistosoma mansoni P2X receptor subunit 0.0342 0.1211 0.1325
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.003 0.0048 0.0065
Trypanosoma brucei brix domain containing protein, putative 0.0062 0.0169 0.0233
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0044 0.0103 0.078
Loa Loa (eye worm) hypothetical protein 0.0055 0.0143 0.0155
Echinococcus multilocularis orexin receptor type 2 0.0055 0.0143 0.0142
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0037 0.0076 0.0554
Brugia malayi hypothetical protein 0.0041 0.009 0.0097
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.0009 0.0008
Brugia malayi Brix domain containing protein 0.0062 0.0169 0.0184
Schistosoma mansoni heat shock protein 0.0134 0.0437 0.0477
Echinococcus granulosus neuropeptide receptor 0.0055 0.0143 0.0155
Mycobacterium tuberculosis Probable two component sensor kinase 0.0108 0.0341 0.2765
Loa Loa (eye worm) hypothetical protein 0.0027 0.004 0.0042
Trichomonas vaginalis receptor histidine kinase, putative 0.0108 0.0341 0.272
Loa Loa (eye worm) hypothetical protein 0.0055 0.0143 0.0155
Brugia malayi follicle stimulating hormone receptor 0.0055 0.0143 0.0155
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0068 0.019 0.0207
Loa Loa (eye worm) heat shock protein 90 0.0134 0.0437 0.0477
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0347 0.1232 1
Schistosoma mansoni hypothetical protein 0.0055 0.0143 0.0155
Trichomonas vaginalis heat shock protein, putative 0.0121 0.039 0.3125
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0108 0.0341 0.0472
Echinococcus granulosus heat shock protein 90 0.0134 0.0437 0.0477
Brugia malayi Calcitonin receptor-like protein seb-1 0.041 0.1468 0.1606
Echinococcus multilocularis poly(ADP ribose) glycohydrolase 0.0173 0.0584 0.0582
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0108 0.0341 0.2744
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.003 0.0101
Loa Loa (eye worm) hypothetical protein 0.0034 0.0066 0.007
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0055 0.0143 0.0155
Trypanosoma brucei pyruvate dehydrogenase (lipoamide) kinase, putative 0.0679 0.2471 0.3438
Schistosoma mansoni DNA topoisomerase II 0.0108 0.0341 0.0372
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0068 0.019 0.0189
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.0143 0.0155
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0055 0.0143 0.0155
Mycobacterium leprae Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP) 0.0347 0.1232 0.1326
Giardia lamblia Grp94/Hsp90 0.003 0.0048 0.0331
Schistosoma mansoni lamin 0.0059 0.0158 0.0172
Echinococcus multilocularis purine nucleoside phosphorylase 0.0347 0.1232 0.1231
Schistosoma mansoni histamine h1 receptor 0.0055 0.0143 0.0155
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0108 0.0341 0.0472
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0055 0.0143 0.0142
Echinococcus granulosus g protein coupled receptor 0.0055 0.0143 0.0155
Onchocerca volvulus Peter pan protein homolog 0.0062 0.0169 0.1362
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0044 0.0103 0.0102
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0026 0.0182
Echinococcus multilocularis Regulator of G protein signaling 20 0.0019 0.0009 0.0008
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.0143 0.0155
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0096 0.0296 0.0294
Mycobacterium leprae Probable two-component sensor kinase 0.0108 0.0341 0.0347
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0055 0.0143 0.0155
Onchocerca volvulus 0.0055 0.0143 0.115
Loa Loa (eye worm) hypothetical protein 0.0055 0.0143 0.0155
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0008 0.0062
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0009 0.0008
Loa Loa (eye worm) neuropeptide F receptor 0.0055 0.0143 0.0155
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.1944 0.7185 0.7184
Schistosoma mansoni biogenic amine receptor 0.0055 0.0143 0.0155
Loa Loa (eye worm) hypothetical protein 0.0055 0.0143 0.0155
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0068 0.019 0.0263
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0091 0.0278 0.0302
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0108 0.0341 1
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0108 0.0341 0.2757
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0019 0.0009 0.0011
Onchocerca volvulus 0.0055 0.0143 0.115
Loa Loa (eye worm) hypothetical protein 0.0055 0.0143 0.0155
Echinococcus multilocularis dro:myosuppressin receptor 0.0055 0.0143 0.0142
Loa Loa (eye worm) hypothetical protein 0.0024 0.0026 0.0027
Onchocerca volvulus 0.0055 0.0143 0.115
Mycobacterium tuberculosis Conserved protein 0.0108 0.0341 0.2765
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0055 0.0143 0.0155
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0347 0.1232 0.1714
Echinococcus multilocularis methylthioadenosine phosphorylase 0.0347 0.1232 0.1231
Loa Loa (eye worm) hypothetical protein 0.0055 0.0143 0.0155
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0108 0.0341 0.2765
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0055 0.0143 0.0155
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0096 0.0296 0.0294
Echinococcus granulosus g-protein coupled receptor 0.0055 0.0143 0.0155
Onchocerca volvulus 0.0055 0.0143 0.115
Loa Loa (eye worm) hypothetical protein 0.013 0.0422 0.046
Loa Loa (eye worm) hypothetical protein 0.0055 0.0143 0.0155
Schistosoma mansoni biogenic amine receptor 0.0055 0.0143 0.0155
Onchocerca volvulus 0.0059 0.0158 0.1274
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0055 0.0143 0.0142
Loa Loa (eye worm) hypothetical protein 0.0055 0.0143 0.0155
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0068 0.019 0.0207
Brugia malayi regulator of G-protein signaling rgs-7 0.0019 0.0009 0.0008
Loa Loa (eye worm) hypothetical protein 0.0055 0.0143 0.0155
Echinococcus granulosus sex peptide receptor 0.0055 0.0143 0.0155
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0009 0.0008
Trypanosoma cruzi heat shock protein 90, putative 0.0121 0.0388 0.0538
Echinococcus multilocularis heat shock protein 0.0134 0.0437 0.0436
Echinococcus multilocularis p2X purinoceptor 4 0.0342 0.1211 0.121
Leishmania major heat shock protein 83-1 0.0134 0.0437 0.0607
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0008 0.0007
Echinococcus granulosus tm gpcr rhodopsin 0.0055 0.0143 0.0155
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0108 0.0341 0.0372
Mycobacterium ulcerans two component sensor kinase MprB 0.0108 0.0341 0.2744
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0108 0.0341 0.1181
Loa Loa (eye worm) hypothetical protein 0.0055 0.0143 0.0155
Echinococcus granulosus purine nucleoside phosphorylase 0.0347 0.1232 0.1348
Schistosoma mansoni methylthioadenosine phosphorylase 0.0347 0.1232 0.1348
Leishmania major heat shock protein 83-1 0.0134 0.0437 0.0607
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.1944 0.7185 0.7184
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0096 0.0296 0.041
Echinococcus granulosus neuropeptides capa receptor 0.0055 0.0143 0.0155
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0021 0.0016 0.002
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0055 0.0143 0.115
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0096 0.0296 0.2401
Echinococcus multilocularis purine nucleoside phosphorylase 0.0347 0.1232 0.1231
Schistosoma mansoni methylthioadenosine phosphorylase 0.0347 0.1232 0.1348
Loa Loa (eye worm) hypothetical protein 0.0055 0.0143 0.0155
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0009 0.0008
Loa Loa (eye worm) hypothetical protein 0.0019 0.0009 0.0008
Leishmania major heat shock protein 83-1 0.0134 0.0437 0.0607
Schistosoma mansoni z-protein (S1r protein) 0.0019 0.0009 0.0008
Trypanosoma brucei heat shock protein 90, putative 0.0134 0.0437 0.0607
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0008 0.0006
Trypanosoma cruzi heat shock protein 85, putative 0.0026 0.0034 0.0045
Echinococcus multilocularis g protein coupled receptor 0.0055 0.0143 0.0142
Leishmania major heat shock protein 83-1 0.0134 0.0437 0.0607
Trypanosoma cruzi poly(ADP-ribose) glycohydrolase, putative 0.0173 0.0584 0.0811
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0055 0.0143 0.0142
Toxoplasma gondii Purine nucleoside phosphorylase 0.0347 0.1232 0.4284
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.0108 0.0341 0.2765
Plasmodium falciparum endoplasmin, putative 0.0121 0.039 0.316
Schistosoma mansoni hypothetical protein 0.0055 0.0143 0.0155
Trypanosoma cruzi pyruvate dehydrogenase (lipoamide) kinase, putative 0.0679 0.2471 0.3438
Schistosoma mansoni hypothetical protein 0.0359 0.1278 0.1398
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0026 0.0027
Onchocerca volvulus 0.0055 0.0143 0.115
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0055 0.0143 0.0155
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.004 0.0085 0.0092
Echinococcus multilocularis heat shock protein 90 0.0026 0.0034 0.0033
Brugia malayi Intermediate filament tail domain containing protein 0.0059 0.0158 0.0172
Trypanosoma brucei heat shock protein 90, putative 0.0134 0.0437 0.0607
Loa Loa (eye worm) hypothetical protein 0.0024 0.0026 0.0027
Trypanosoma cruzi methylthioadenosine phosphorylase, putative 0.0347 0.1232 0.1714
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.041 0.1468 0.1606
Loa Loa (eye worm) hypothetical protein 0.0281 0.0984 0.1076
Treponema pallidum glyceraldehyde 3-phosphate dehydrogenase (gap) 0.0068 0.019 0.1492
Loa Loa (eye worm) latrophilin receptor protein 2 0.013 0.0422 0.046
Echinococcus granulosus neuropeptide Y receptor 0.0055 0.0143 0.0155
Onchocerca volvulus 0.0055 0.0143 0.115
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0055 0.0143 0.0155
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.013 0.0422 0.046
Mycobacterium tuberculosis Hypothetical protein 0.0347 0.1232 1
Mycobacterium tuberculosis Probable bifunctional MTA/SAH nucleosidase Mtn: 5'-methylthioadenosine nucleosidase (methylthioadenosine methylthioribohydrolase 0.0347 0.1232 1
Echinococcus granulosus p2X purinoceptor 4 0.0342 0.1211 0.1325
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0026 0.0034
Entamoeba histolytica hypothetical protein 0.0077 0.0225 0.182
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0068 0.019 0.0263
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0055 0.0143 0.0155
Echinococcus granulosus Regulator of G protein signaling 20 0.0019 0.0009 0.0008
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0009 0.0008
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0008 0.0009
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0347 0.1232 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0008 0.0007
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0068 0.019 0.1536
Onchocerca volvulus 0.0055 0.0143 0.115
Echinococcus multilocularis g protein coupled receptor 0.0055 0.0143 0.0142
Brugia malayi hypothetical protein 0.0055 0.0143 0.0155
Echinococcus multilocularis purine nucleoside phosphorylase 0.0347 0.1232 0.1231
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0055 0.0143 0.0155
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0009 0.0008
Loa Loa (eye worm) hypothetical protein 0.0019 0.0009 0.0008
Plasmodium vivax glyceraldehyde-3-phosphate dehydrogenase, putative 0.0068 0.019 0.1536
Schistosoma mansoni 23-cyclic-nucleotide 2-phosphodiesterase 0.0139 0.0454 0.0496
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0055 0.0143 0.0155
Trichomonas vaginalis receptor histidine kinase, putative 0.0108 0.0341 0.272
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0068 0.019 0.0263
Echinococcus multilocularis neuropeptide FF receptor 2 0.0055 0.0143 0.0142
Loa Loa (eye worm) hypothetical protein 0.0055 0.0143 0.0155
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0108 0.0341 0.2765
Mycobacterium tuberculosis Conserved hypothetical protein 0.0347 0.1232 1
Echinococcus multilocularis lamin dm0 0.0059 0.0158 0.0157
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.0044 0.0103 0.0112
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0009 0.0008
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.0108 0.0341 1
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.003 0.0048 0.0026
Toxoplasma gondii isocitrate dehydrogenase 0.0096 0.0296 0.1025
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0108 0.0341 0.272
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0026 0.0182
Schistosoma mansoni hypothetical protein 0.013 0.0422 0.046
Echinococcus multilocularis sex peptide receptor 0.0055 0.0143 0.0142
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.003 0.004
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0055 0.0143 0.0142
Plasmodium vivax DNA topoisomerase II, putative 0.0108 0.0341 0.2757
Loa Loa (eye worm) hypothetical protein 0.0108 0.0341 0.0372
Schistosoma mansoni neuropeptide receptor 0.0055 0.0143 0.0155
Entamoeba histolytica poly(ADP-ribose) glycohydrolase, putative 0.0173 0.0584 0.4731
Toxoplasma gondii heat shock protein HSP90 0.0134 0.0437 0.1517
Loa Loa (eye worm) hypothetical protein 0.0055 0.0143 0.0155
Loa Loa (eye worm) hypothetical protein 0.0055 0.0143 0.0155
Loa Loa (eye worm) hypothetical protein 0.0055 0.0143 0.0155
Trypanosoma cruzi peter pan protein, putative 0.0062 0.0169 0.0233
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0068 0.019 0.0207
Trichomonas vaginalis heat shock protein, putative 0.003 0.0048 0.0331
Onchocerca volvulus Purine nucleoside phosphorylase homolog 0.0347 0.1232 1
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0068 0.019 0.1536
Loa Loa (eye worm) hypothetical protein 0.0055 0.0143 0.0155
Plasmodium falciparum glyceraldehyde-3-phosphate dehydrogenase 0.0068 0.019 0.1536
Brugia malayi Dopamine receptor protein 1 0.0055 0.0143 0.0155
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0026 0.0182
Schistosoma mansoni amine GPCR 0.0055 0.0143 0.0155
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0347 0.1232 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.0055 0.0143 0.0155
Schistosoma mansoni pyruvate dehydrogenase 0.1835 0.6782 0.7426
Loa Loa (eye worm) hypothetical protein 0.0108 0.0341 0.0372
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH2 0.0068 0.019 0.0658
Schistosoma mansoni hypothetical protein 0.0055 0.0143 0.0155
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0108 0.0341 0.2757
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0055 0.0143 0.0155
Brugia malayi intermediate filament protein 0.0059 0.0158 0.0172
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0091 0.0278 0.0276
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0009 0.0008
Echinococcus granulosus neuropeptide receptor A26 0.0055 0.0143 0.0155
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0096 0.0296 0.041
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.008 0.0236 0.0257
Loa Loa (eye worm) hypothetical protein 0.0019 0.0009 0.0008
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.008 0.0236 0.0235
Schistosoma mansoni amine GPCR 0.0055 0.0143 0.0155
Trypanosoma cruzi heat shock protein 90, putative 0.0134 0.0437 0.0607
Loa Loa (eye worm) pigment dispersing factor receptor c 0.041 0.1468 0.1606
Brugia malayi latrophilin 2 splice variant baaae 0.0281 0.0984 0.1076
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0091 0.0278 0.0276
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0029 0.0044 0.0047
Loa Loa (eye worm) hypothetical protein 0.0055 0.0143 0.0155
Loa Loa (eye worm) Poly(ADP-ribose) glycohydrolase 0.0173 0.0584 0.0638
Toxoplasma gondii isocitrate dehydrogenase 0.0096 0.0296 0.1025
Schistosoma mansoni amine GPCR 0.0055 0.0143 0.0155
Echinococcus multilocularis beta adrenergic receptor kinase 0.0019 0.0009 0.0008
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0096 0.0296 0.041
Plasmodium falciparum purine nucleoside phosphorylase 0.0347 0.1232 1
Echinococcus granulosus serotonin receptor 0.0055 0.0143 0.0155
Loa Loa (eye worm) RGS-3 protein 0.0019 0.0009 0.0008
Entamoeba histolytica poly(ADP-ribose) glycohydrolase, putative 0.0077 0.0225 0.182
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.0143 0.0142
Brugia malayi Serotonin receptor 0.0055 0.0143 0.0155
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0068 0.019 0.1536
Brugia malayi putative neuropeptide receptor 0.0055 0.0143 0.0155
Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase, putative 0.0044 0.0103 0.0142
Mycobacterium ulcerans DNA gyrase subunit B 0.0108 0.0341 0.2744
Toxoplasma gondii phosphorylase family protein 0.0347 0.1232 0.4284
Loa Loa (eye worm) hypothetical protein 0.0055 0.0143 0.0155
Brugia malayi G protein-coupled receptor 0.0055 0.0143 0.0155
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.003 0.0236
Loa Loa (eye worm) hypothetical protein 0.0055 0.0143 0.0155
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0068 0.019 0.0263
Plasmodium falciparum DNA gyrase subunit B 0.0108 0.0341 0.2757
Trypanosoma brucei heat shock protein, putative 0.0134 0.0437 0.0607
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0009 0.0011
Schistosoma mansoni hypothetical protein 0.0359 0.1278 0.1398
Schistosoma mansoni purine nucleoside phosphorylase 0.0347 0.1232 0.1348
Brugia malayi larval opioid receptor 0.0055 0.0143 0.0155
Trichomonas vaginalis conserved hypothetical protein 0.0347 0.1232 1
Trypanosoma brucei heat shock protein, putative 0.0134 0.0437 0.0607
Echinococcus multilocularis purine nucleoside phosphorylase 0.0347 0.1232 0.1231
Brugia malayi Tachykinin-like peptides receptor 99D 0.0055 0.0143 0.0155
Brugia malayi hypothetical protein 0.0055 0.0143 0.0155
Echinococcus multilocularis g protein coupled receptor 0.0055 0.0143 0.0142
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.013 0.0422 0.046
Leishmania major heat shock protein 83-1 0.0134 0.0437 0.0607
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.0143 0.0155
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.003 0.004
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0108 0.0341 0.272
Trichomonas vaginalis DNA topoisomerase II, putative 0.0108 0.0341 0.272
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.0143 0.0155
Loa Loa (eye worm) hypothetical protein 0.0055 0.0143 0.0155
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0009 0.0008
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0096 0.0296 0.2392
Echinococcus granulosus neuropeptide s receptor 0.0055 0.0143 0.0155
Schistosoma mansoni hypothetical protein 0.013 0.0422 0.046
Echinococcus granulosus dnaJ subfamily B 0.2053 0.7594 0.8315
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0019 0.0009 0.0008
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.0143 0.0155
Schistosoma mansoni biogenic amine (5HT) receptor 0.0055 0.0143 0.0155
Entamoeba histolytica hypothetical protein 0.0019 0.0009 0.0062
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.0047 0.0112 0.0121
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0055 0.0143 0.0142
Echinococcus granulosus polyADP ribose glycohydrolase 0.0173 0.0584 0.0638
Loa Loa (eye worm) hypothetical protein 0.0055 0.0143 0.0155
Trichomonas vaginalis conserved hypothetical protein 0.0347 0.1232 1
Echinococcus multilocularis lamin 0.0059 0.0158 0.0157
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.0108 0.0341 0.272
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0055 0.0143 0.0142
Loa Loa (eye worm) G-protein coupled receptor 0.0055 0.0143 0.0155
Echinococcus granulosus fmrfamide receptor 0.0055 0.0143 0.0155
Echinococcus multilocularis g-protein coupled receptor 0.0055 0.0143 0.0142
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.0021 0.0016 0.002
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0068 0.019 0.1492
Leishmania major pyruvate dehydrogenase (lipoamide) kinase, putative 0.0679 0.2471 0.3438
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0044 0.0103 0.078
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0009 0.0008
Brugia malayi MH2 domain containing protein 0.0116 0.0371 0.0405
Plasmodium vivax DNA gyrase subunit B, putative 0.0108 0.0341 0.2757
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0008 0.0051
Echinococcus multilocularis isocitrate dehydrogenase 0.0096 0.0296 0.0294
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0055 0.0143 0.0142
Schistosoma mansoni biogenic amine receptor 0.0055 0.0143 0.0155
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.0108 0.0341 0.0347
Brugia malayi isocitrate dehydrogenase 0.0096 0.0296 0.0322
Loa Loa (eye worm) hypothetical protein 0.0055 0.0143 0.0155
Entamoeba histolytica brix domain containing protein 0.0062 0.0169 0.1362
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0108 0.0341 0.2765
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.0009 0.0008
Loa Loa (eye worm) hypothetical protein 0.0025 0.003 0.0032
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0004 0.0029
Trypanosoma brucei heat shock protein, putative 0.0134 0.0437 0.0607
Trypanosoma cruzi DNA topoisomerase II, putative 0.0108 0.0341 0.0472
Echinococcus granulosus tm gpcr rhodopsin 0.0055 0.0143 0.0155
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0068 0.019 0.1492
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0055 0.0143 0.0142
Echinococcus multilocularis neuropeptide s receptor 0.0055 0.0143 0.0142
Brugia malayi AKH receptor 0.0055 0.0143 0.0155
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0108 0.0341 0.272
Echinococcus granulosus 7tm_1 domain containing protein 0.0055 0.0143 0.0155
Toxoplasma gondii phosphorylase family protein 0.0347 0.1232 0.4284
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0347 0.1232 0.1714
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0068 0.019 0.1492
Leishmania major heat shock protein 83-1 0.0134 0.0437 0.0607
Echinococcus granulosus heat shock protein 90 0.0026 0.0034 0.0036
Schistosoma mansoni alpha-1 adrenergic receptor 0.0055 0.0143 0.0155
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0009 0.0008
Echinococcus granulosus purine nucleoside phosphorylase 0.0347 0.1232 0.1348
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0108 0.0341 0.2765
Loa Loa (eye worm) hypothetical protein 0.0027 0.004 0.0042
Giardia lamblia Heat shock protein HSP 90-alpha 0.0134 0.0437 0.3507
Leishmania major heat shock protein 83-1 0.0134 0.0437 0.0607
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0108 0.0341 0.0472
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0108 0.0341 0.2744
Echinococcus multilocularis allatostatin A receptor 0.0055 0.0143 0.0142
Trypanosoma brucei heat shock protein, putative 0.0134 0.0437 0.0607
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0068 0.019 0.0207
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.0044 0.0103 0.0142
Plasmodium vivax heat shock protein 86, putative 0.0134 0.0437 0.354
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0019 0.0009 0.0008
Loa Loa (eye worm) intermediate filament protein 0.0059 0.0158 0.0172
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0108 0.0341 0.2744
Echinococcus granulosus lamin 0.0059 0.0158 0.0172
Echinococcus granulosus purine nucleoside phosphorylase 0.0347 0.1232 0.1348
Loa Loa (eye worm) hypothetical protein 0.0018 0.0004 0.0002
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0055 0.0143 0.0142
Echinococcus granulosus allatostatin A receptor 0.0055 0.0143 0.0155
Mycobacterium ulcerans two component regulator - sensor kinase 0.0108 0.0341 0.2744
Loa Loa (eye worm) hypothetical protein 0.0055 0.0143 0.0155
Echinococcus multilocularis neuropeptide Y receptor 0.0055 0.0143 0.0142
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.0143 0.0155
Loa Loa (eye worm) hypothetical protein 0.0055 0.0143 0.0155
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0094 0.0287 0.0995
Echinococcus granulosus lamin dm0 0.0059 0.0158 0.0172
Echinococcus granulosus intermediate filament protein 0.0059 0.0158 0.0172
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.008 0.0236 0.0257
Loa Loa (eye worm) hypothetical protein 0.0059 0.0158 0.0172
Entamoeba histolytica heat shock protein 90, putative 0.0134 0.0437 0.354
Echinococcus granulosus neuropeptides capa receptor 0.0055 0.0143 0.0155
Treponema pallidum heat shock protein 90 0.003 0.0048 0.0331
Brugia malayi Latrophilin receptor protein 2 0.013 0.0422 0.046
Loa Loa (eye worm) hypothetical protein 0.0019 0.0009 0.0008
Giardia lamblia UPL-1 0.0347 0.1232 1
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0091 0.0278 0.0302
Brugia malayi heat shock protein 90 0.0134 0.0437 0.0477
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0096 0.0296 0.2392
Toxoplasma gondii exonuclease III APE 0.0019 0.0008 0.0022
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.0044 0.0103 0.0142
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.013 0.0422 0.046
Plasmodium vivax hypothetical protein, conserved 0.0108 0.0341 0.2757
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0009 0.0008
Loa Loa (eye worm) hypothetical protein 0.0018 0.0004 0.0002
Echinococcus granulosus uridine phosphorylase 1 0.2466 0.9132 1
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.0021 0.0016 0.002
Onchocerca volvulus 0.0024 0.0026 0.0199
Schistosoma mansoni hypothetical protein 0.0041 0.009 0.0097
Echinococcus granulosus heat shock protein 0.0134 0.0437 0.0477
Echinococcus granulosus GPCR family 2 0.013 0.0422 0.046
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0021 0.0016 0.002
Echinococcus multilocularis neuropeptide Y receptor 0.0055 0.0143 0.0142
Brugia malayi ORL1-like opioid receptor 0.0055 0.0143 0.0155
Mycobacterium leprae Probable two component sensor kinase MprB 0.0108 0.0341 0.0347
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0108 0.0341 0.272
Loa Loa (eye worm) hypothetical protein 0.0055 0.0143 0.0155
Brugia malayi hypothetical protein 0.0055 0.0143 0.0155
Echinococcus multilocularis zinc finger protein 598 0.0062 0.0168 0.0166
Brugia malayi Melatonin receptor type 1A 0.0055 0.0143 0.0155
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0055 0.0143 0.0155
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.003 0.0236
Echinococcus granulosus peptide allatostatin:somatostatin 0.0055 0.0143 0.0155
Trichomonas vaginalis heat shock protein, putative 0.003 0.0048 0.0331
Trypanosoma cruzi heat shock protein 85, putative 0.0134 0.0437 0.0607
Trypanosoma cruzi Heat shock protein 83, putative 0.0134 0.0437 0.0607
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0055 0.0143 0.0142
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0009 0.0011
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0026 0.0034
Schistosoma mansoni amine GPCR 0.0055 0.0143 0.0155
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0026 0.0034
Schistosoma mansoni methylthioadenosine phosphorylase 0.0347 0.1232 0.1348
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.0143 0.0142
Brugia malayi sulfakinin receptor protein 0.0055 0.0143 0.0155
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0068 0.019 0.1492
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0055 0.0143 0.0155
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.0108 0.0341 0.2757
Leishmania major peter pan protein, putative 0.0062 0.0169 0.0233
Schistosoma mansoni endoplasmin 0.0134 0.0437 0.0477
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0009 0.0008
Brugia malayi GnHR receptor homolog 0.0055 0.0143 0.0155
Brugia malayi RE15519p 0.0055 0.0143 0.0155
Echinococcus multilocularis dnaJ subfamily B 0.2053 0.7594 0.7594
Loa Loa (eye worm) hypothetical protein 0.0018 0.0004 0.0002
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0026 0.0001
Trypanosoma brucei Heat shock protein 83, putative 0.0134 0.0437 0.0607
Echinococcus granulosus purine nucleoside phosphorylase 0.0347 0.1232 0.1348
Entamoeba histolytica hypothetical protein 0.0041 0.009 0.0717
Schistosoma mansoni neuropeptide receptor 0.0055 0.0143 0.0155
Brugia malayi hypothetical protein 0.0055 0.0143 0.0155
Brugia malayi A-kinase anchor protein 10, precursor 0.0019 0.0009 0.0008
Trypanosoma brucei heat shock protein, putative 0.0134 0.0437 0.0607
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.0143 0.0155
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0009 0.0011
Chlamydia trachomatis AMP nucleosidase 0.0347 0.1232 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0055 0.0143 0.0155
Schistosoma mansoni heat shock protein 0.0134 0.0437 0.0477
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0004 0.0018
Trypanosoma brucei heat shock protein, putative 0.0134 0.0437 0.0607
Trypanosoma brucei developmentally regulated phosphoprotein 0.1944 0.7185 1
Plasmodium vivax purine nucleoside phosphorylase, putative 0.0347 0.1232 1
Loa Loa (eye worm) TYRA-2 protein 0.0055 0.0143 0.0155
Echinococcus multilocularis neuropeptides capa receptor 0.0055 0.0143 0.0142
Onchocerca volvulus 0.0055 0.0143 0.115
Giardia lamblia Purine nucleoside phosphorylase lateral transfer candidate 0.0347 0.1232 1
Echinococcus granulosus g protein coupled receptor 0.0055 0.0143 0.0155
Brugia malayi purine nucleoside phosphorylase I, inosine and guanosine-specific family protein 0.0347 0.1232 0.1348
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0023 0.0025 0.0026
Chlamydia trachomatis DNA gyrase subunit B 0.0108 0.0341 0.2744
Giardia lamblia Heat shock protein HSP 90-alpha 0.0026 0.0034 0.0215
Schistosoma mansoni voltage-gated potassium channel 0.0043 0.0099 0.0107
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0009 0.0008
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.0371 0.0405
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0055 0.0143 0.0155
Leishmania major heat shock protein 83-1 0.0134 0.0437 0.0607
Loa Loa (eye worm) hypothetical protein 0.0055 0.0143 0.0155
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0009 0.0008
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0009 0.0008
Schistosoma mansoni neuropeptide f receptor 76f 0.0055 0.0143 0.0155
Echinococcus granulosus neuropeptide Y receptor 0.0055 0.0143 0.0155
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0347 0.1232 1
Giardia lamblia Hypothetical protein 0.0057 0.0149 0.1153
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0108 0.0341 0.1181
Brugia malayi hypothetical protein 0.0055 0.0143 0.0155
Schistosoma mansoni growth hormone secretagogue receptor 0.0055 0.0143 0.0155
Treponema pallidum uridine phosphorylase (udp) 0.0347 0.1232 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0143 0.0155
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0055 0.0143 0.0155
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0055 0.0143 0.0155
Toxoplasma gondii poly(ADP-ribose) glycohydrolase 0.0077 0.0225 0.078
Echinococcus multilocularis geminin 0.0359 0.1278 0.1277
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.013 0.0422 0.042
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.0108 0.0341 0.0347
Leishmania major heat shock protein 83-1 0.0134 0.0437 0.0607
Echinococcus multilocularis neuropeptide receptor A26 0.0055 0.0143 0.0142
Leishmania major hypothetical protein, conserved 0.0108 0.0341 0.0472
Schistosoma mansoni lamin 0.0059 0.0158 0.0172
Giardia lamblia 5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase 0.0347 0.1232 1
Onchocerca volvulus 0.0055 0.0143 0.115
Echinococcus granulosus g protein coupled receptor 0.0055 0.0143 0.0155
Mycobacterium ulcerans putative regultory protein 0.0108 0.0341 0.2744
Mycobacterium ulcerans glyceraldehyde 3-phosphate dehydrogenase Gap 0.0068 0.019 0.1521
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0026 0.0034 0.0036
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0096 0.0296 0.041
Wolbachia endosymbiont of Brugia malayi glyceraldehyde-3-phosphate dehydrogenase, GapA 0.0068 0.019 0.5488
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0055 0.0143 0.0142
Echinococcus multilocularis purine nucleoside phosphorylase 0.0347 0.1232 0.1231
Schistosoma mansoni neuropeptide F-like receptor 0.0055 0.0143 0.0155
Brugia malayi G protein-coupled receptor F59B2.13 0.0055 0.0143 0.0155
Echinococcus multilocularis musashi 0.0059 0.0158 0.0157
Echinococcus multilocularis fmrfamide receptor 0.0055 0.0143 0.0142
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.004 0.0085 0.0084
Schistosoma mansoni intermediate filament proteins 0.0059 0.0158 0.0172
Brugia malayi hypothetical protein 0.0055 0.0143 0.0155
Loa Loa (eye worm) uridine phosphorylase 0.2466 0.9132 1
Echinococcus granulosus zinc finger protein 598 0.0062 0.0168 0.0182
Echinococcus granulosus 7TM GPCR rhodopsin 0.0055 0.0143 0.0155
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.0143 0.0155
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0026 0.0182
Giardia lamblia Pms1-like protein 0.0108 0.0341 0.272
Loa Loa (eye worm) hypothetical protein 0.0055 0.0143 0.0155
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0108 0.0341 0.0472
Toxoplasma gondii poly(ADP-ribose) glycohydrolase 0.0173 0.0584 0.2027
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.003 0.0048 0.1218
Mycobacterium ulcerans hypothetical protein 0.0024 0.0026 0.0182
Schistosoma mansoni ap endonuclease 0.0019 0.0008 0.0007
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0009 0.0008
Leishmania major glyceraldehyde-3-phosphate dehydrogenase-like protein 0.0044 0.0103 0.0142
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.013 0.0422 0.042
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0347 0.1232 1
Echinococcus multilocularis peter pan 0.0062 0.0169 0.0168
Echinococcus multilocularis G protein coupled receptor 139 0.0055 0.0143 0.0142
Loa Loa (eye worm) hypothetical protein 0.0055 0.0143 0.0155
Loa Loa (eye worm) hypothetical protein 0.041 0.1468 0.1606
Leishmania major methylthioadenosine phosphorylase, putative 0.0347 0.1232 0.1714
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0055 0.0143 0.0155
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.1944 0.7185 1
Echinococcus multilocularis uridine phosphorylase 1 0.2466 0.9132 0.9132
Brugia malayi hypothetical protein 0.0019 0.0009 0.0008
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0055 0.0143 0.0155
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.003 0.0236
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0347 0.1232 0.1714
Brugia malayi hypothetical protein 0.0025 0.003 0.0032
Treponema pallidum chemotaxis histidine kinase (cheA) 0.0108 0.0341 0.272
Toxoplasma gondii 5'-nucleotidase, C-terminal domain-containing protein 0.0057 0.015 0.0518
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.0371 0.0405
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0055 0.0143 0.0155
Plasmodium vivax endoplasmin, putative 0.0134 0.0437 0.354
Echinococcus granulosus potassium voltage gated channel subfamily H 0.004 0.0085 0.0092
Giardia lamblia Peter pan protein 0.0062 0.0169 0.1318
Trypanosoma brucei DNA topoisomerase ii 0.0108 0.0341 0.0472
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0026 0.0199
Mycobacterium ulcerans purine nucleoside phosphorylase 0.0347 0.1232 1
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0009 0.0008
Loa Loa (eye worm) hypothetical protein 0.0018 0.0004 0.0002
Plasmodium falciparum DNA topoisomerase 2 0.0108 0.0341 0.2757
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0068 0.019 0.0263
Schistosoma mansoni purine nucleoside phosphorylase 0.0347 0.1232 0.1348
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0019 0.0009 0.0008
Schistosoma mansoni hypothetical protein 0.013 0.0422 0.046
Entamoeba histolytica heat shock protein 90, putative 0.0134 0.0437 0.354
Entamoeba histolytica MTA/SAH nucleosidase, putative 0.0347 0.1232 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0143 0.0155
Schistosoma mansoni neuropeptide receptor 0.0055 0.0143 0.0155
Schistosoma mansoni uridine phosphorylase 0.2466 0.9132 1
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.008 0.0236 0.0257
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0108 0.0341 0.2744
Echinococcus multilocularis expressed protein 0.0373 0.1329 0.1328
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0108 0.0341 0.2765
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0096 0.0296 0.0294
Echinococcus multilocularis GPCR, family 2 0.013 0.0422 0.042
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0055 0.0143 0.0155
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, cytosolic 0.0068 0.019 0.0263
Schistosoma mansoni poly(ADP-ribose) glycohydrolase 0.0173 0.0584 0.0638
Trypanosoma cruzi heat shock protein 90, putative 0.0026 0.0034 0.0045
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.0047 0.0112 0.0121
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0055 0.0143 0.0142
Trichomonas vaginalis endoplasmin, putative 0.0121 0.039 0.3125
Plasmodium vivax hypothetical protein, conserved 0.0062 0.0169 0.1362
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0055 0.0143 0.0155
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.0143 0.0155
Wolbachia endosymbiont of Brugia malayi membrane associated signal transduction histidine kinase 0.0108 0.0341 1
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0009 0.0008
Leishmania major hypothetical protein, conserved 0.0025 0.003 0.004
Plasmodium falciparum heat shock protein 90 0.0134 0.0437 0.354
Echinococcus multilocularis neuropeptides capa receptor 0.0055 0.0143 0.0142
Loa Loa (eye worm) hypothetical protein 0.0055 0.0143 0.0155
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0055 0.0143 0.0155
Loa Loa (eye worm) hypothetical protein 0.0055 0.0143 0.0155
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0108 0.0341 0.2744
Entamoeba histolytica hypothetical protein 0.0019 0.0009 0.0062
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0026 0.0182
Schistosoma mansoni peter pan-related 0.0062 0.0169 0.0184
Loa Loa (eye worm) hypothetical protein 0.0029 0.0044 0.0047
Giardia lamblia 5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase 0.0347 0.1232 1
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.003 0.0048 0.0391
Brugia malayi hypothetical protein 0.0055 0.0143 0.0155
Brugia malayi hypothetical protein 0.0055 0.0143 0.0155
Leishmania major mitochondrial DNA topoisomerase II 0.0108 0.0341 0.0472
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0021 0.0016 0.002
Onchocerca volvulus 0.0055 0.0143 0.115
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0055 0.0143 0.0155
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0008 0.0033
Mycobacterium tuberculosis Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) 0.0023 0.0025 0.0202
Schistosoma mansoni voltage-gated potassium channel 0.0043 0.0099 0.0107
Entamoeba histolytica hypothetical protein 0.0347 0.1232 1
Leishmania major heat shock protein 83-1 0.0134 0.0437 0.0607
Trichomonas vaginalis sensor histidine kinase, putative 0.0108 0.0341 0.272
Echinococcus multilocularis p2X purinoceptor 4 0.0342 0.1211 0.121
Chlamydia trachomatis DNA gyrase subunit B 0.0108 0.0341 0.2744
Loa Loa (eye worm) S-methyl-5'-thioadenosine phosphorylase MTAP 0.0347 0.1232 0.1348
Loa Loa (eye worm) hypothetical protein 0.0055 0.0143 0.0155
Echinococcus granulosus orexin receptor type 2 0.0055 0.0143 0.0155
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0026 0.0199
Onchocerca volvulus 0.0055 0.0143 0.115
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0108 0.0341 0.0372
Brugia malayi cytoplasmic intermediate filament protein 0.0032 0.0056 0.006
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0009 0.0008
Trypanosoma brucei methylthioadenosine phosphorylase, putative 0.0347 0.1232 0.1714
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0108 0.0341 0.0472
Loa Loa (eye worm) brix domain-containing protein 0.0062 0.0169 0.0184
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0008 0.0009
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0055 0.0143 0.0155
Brugia malayi putative neuropeptide receptor NPR1 0.0055 0.0143 0.0155
Treponema pallidum pfs protein (pfs) 0.0347 0.1232 1
Brugia malayi Dopamine receptor protein 2 0.0055 0.0143 0.0155
Echinococcus granulosus tm gpcr rhodopsin 0.0055 0.0143 0.0155
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0068 0.019 0.0263
Echinococcus granulosus purine nucleoside phosphorylase 0.0347 0.1232 0.1348
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0108 0.0341 0.2765
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0004 0.0018
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.0044 0.0103 0.0112
Loa Loa (eye worm) PXA domain-containing protein 0.0019 0.0009 0.0008
Loa Loa (eye worm) hypothetical protein 0.0058 0.0154 0.0167
Leishmania major heat shock protein 83-1 0.0134 0.0437 0.0607
Schistosoma mansoni hypothetical protein 0.2053 0.7594 0.8315
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0037 0.0076 0.0554
Brugia malayi uridine phosphorylase family protein 0.2466 0.9132 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0032 0.0056 0.006
Loa Loa (eye worm) G-protein coupled receptor 0.0055 0.0143 0.0155
Schistosoma mansoni 23-cyclic-nucleotide 2-phosphodiesterase 0.0138 0.0453 0.0494
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.0143 0.0155
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.004 0.0085 0.0092
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0108 0.0341 0.2744
Echinococcus granulosus G protein coupled receptor 139 0.0055 0.0143 0.0155
Trichomonas vaginalis heat shock protein, putative 0.0134 0.0437 0.3507
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0091 0.0278 0.0302
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.0143 0.0155
Echinococcus multilocularis neuropeptide receptor 0.0055 0.0143 0.0142
Onchocerca volvulus 0.0055 0.0143 0.115
Echinococcus multilocularis G-protein coupled receptor, putative 0.0055 0.0143 0.0142
Loa Loa (eye worm) neuropeptide F receptor 0.0055 0.0143 0.0155
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.0143 0.0155
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0008 0.0007
Schistosoma mansoni biogenic amine (5HT) receptor 0.0055 0.0143 0.0155
Echinococcus multilocularis regulator of G protein signaling 0.0019 0.0009 0.0008
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0096 0.0296 0.0322
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0068 0.019 0.1492
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0108 0.0341 0.0472
Leishmania major heat shock protein 83-1 0.0134 0.0437 0.0607
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0026 0.0182
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0068 0.019 0.0263
Treponema pallidum 5'-nucleotidase (ushA) 0.0139 0.0454 0.3647
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0019 0.0009 0.0008
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0026 0.0027
Loa Loa (eye worm) hypothetical protein 0.0989 0.3625 0.3969
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0068 0.019 0.0207
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0055 0.0143 0.0155
Onchocerca volvulus 0.0059 0.0158 0.1274
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0026 0.0211
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0026 0.0027
Brugia malayi Probable DNA topoisomerase II 0.0108 0.0341 0.0372
Echinococcus granulosus neuropeptide receptor 0.0055 0.0143 0.0155
Schistosoma mansoni hypothetical protein 0.0055 0.0143 0.0155
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0068 0.019 0.0263
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0019 0.0009 0.0008
Loa Loa (eye worm) hypothetical protein 0.0019 0.0009 0.0008
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0788 0.2874 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0026 0.0027
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0108 0.0341 0.2744
Entamoeba histolytica hypothetical protein 0.0173 0.0584 0.4731
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.0143 0.0142
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.0143 0.0142
Brugia malayi PXA domain containing protein 0.0019 0.0009 0.0008
Brugia malayi hypothetical protein 0.0055 0.0143 0.0155
Trypanosoma cruzi poly(ADP-ribose) glycohydrolase, putative 0.0173 0.0584 0.0811
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0096 0.0296 0.0294
Schistosoma mansoni ap endonuclease 0.0019 0.0008 0.0007
Mycobacterium ulcerans bifunctional Mta/Sah nucleosidase Mtn 0.0347 0.1232 1
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0108 0.0341 0.272
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0055 0.0143 0.0155
Loa Loa (eye worm) hypothetical protein 0.0055 0.0143 0.0155
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0009 0.0008
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0008 0.0051
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0108 0.0341 0.2765
Brugia malayi neuropeptide F receptor 0.0055 0.0143 0.0155
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0019 0.0009 0.0008
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0347 0.1232 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0026 0.0211
Echinococcus granulosus purine nucleoside phosphorylase 0.0347 0.1232 0.1348
Trypanosoma cruzi methylthioadenosine phosphorylase, putative 0.0347 0.1232 0.1714
Echinococcus multilocularis neuropeptide receptor 0.0055 0.0143 0.0142
Brugia malayi Endoplasmin precursor 0.0134 0.0437 0.0477
Schistosoma mansoni adenoreceptor 0.0055 0.0143 0.0155
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.0143 0.0155
Echinococcus granulosus somatostatin receptor 0.0055 0.0143 0.0155
Toxoplasma gondii 5'-nucleotidase, C-terminal domain-containing protein 0.0139 0.0454 0.1577
Schistosoma mansoni amine GPCR 0.0055 0.0143 0.0155
Mycobacterium tuberculosis Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP) 0.0347 0.1232 1
Echinococcus multilocularis purine nucleoside phosphorylase 0.0347 0.1232 0.1231
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.0143 0.0155
Echinococcus multilocularis serotonin receptor 0.0055 0.0143 0.0142
Entamoeba histolytica DNA topoisomerase II, putative 0.0108 0.0341 0.2757
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0347 0.1232 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0041 0.009 0.0097
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0068 0.019 0.0189
Echinococcus granulosus dro:myosuppressin receptor 0.0055 0.0143 0.0155
Brugia malayi Serotonin receptor 0.0055 0.0143 0.0155

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) = 21 % Percent inhibition of cholesterol side-chain cleavage cytochrome P450 at 100 uM in bovine adrenocortical mitochondrial acetone powder preparations ChEMBL. 7288817

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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