Detailed information for compound 1556408

Basic information

Technical information
  • TDR Targets ID: 1556408
  • Name: 8-[8-(1H-benzimidazol-2-yl)octyl]-1,3-dimethy l-7H-purine-2,6-dione
  • MW: 408.497 | Formula: C22H28N6O2
  • H donors: 2 H acceptors: 4 LogP: 4.35 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cn1c2[nH]c(nc2c(=O)n(c1=O)C)CCCCCCCCc1nc2c([nH]1)cccc2
  • InChi: 1S/C22H28N6O2/c1-27-20-19(21(29)28(2)22(27)30)25-18(26-20)14-8-6-4-3-5-7-13-17-23-15-11-9-10-12-16(15)24-17/h9-12H,3-8,13-14H2,1-2H3,(H,23,24)(H,25,26)
  • InChiKey: YROFFLLIXZJIPV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 8-[8-(1H-benzimidazol-2-yl)octyl]-1,3-dimethyl-7H-purine-2,6-quinone
  • NSC81512

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens nuclear receptor subfamily 2, group F, member 1 Starlite/ChEMBL No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Homo sapiens isocitrate dehydrogenase 1 (NADP+), soluble Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Homo sapiens parathyroid hormone 1 receptor Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K04588 secretin receptor, putative Get druggable targets OG5_139196 All targets in OG5_139196
Trypanosoma brucei gambiense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Babesia bovis isocitrate dehydrogenase, NADP-dependent family protein Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor Get druggable targets OG5_131829 All targets in OG5_131829
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi Steroid receptor seven-up type 2 Get druggable targets OG5_131829 All targets in OG5_131829
Leishmania donovani isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131829 All targets in OG5_131829
Plasmodium knowlesi isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Trypanosoma cruzi isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium berghei isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum ko:K00031 isocitrate dehydrogenase [EC1.1.1.42], putative Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum Isocitrate dehydrogenase-like protein, related Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi Isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania braziliensis isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor Get druggable targets OG5_131829 All targets in OG5_131829
Brugia malayi isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans C terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania mexicana isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma brucei isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) nuclear hormone receptor Get druggable targets OG5_131829 All targets in OG5_131829
Loa Loa (eye worm) isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Neospora caninum hypothetical protein Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania infantum isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Theileria parva isocitrate dehydrogenase (NADP+), putative Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans N terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Brugia malayi ecdysteroid receptor nuclear receptor subfamily 2, group F, member 1 423 aa 354 aa 26.3 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0142 0.0499 0.1704
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0119 0.2384
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0105 0.0348 0.1189
Loa Loa (eye worm) hypothetical protein 0.0055 0.0146 0.05
Onchocerca volvulus 0.0196 0.0718 0.2229
Loa Loa (eye worm) hypothetical protein 0.0142 0.0499 0.1704
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0105 0.0348 0.1189
Brugia malayi beta-lactamase family protein 0.011 0.0368 0.1258
Onchocerca volvulus Putative cubilin 0.0072 0.0213 0.0455
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0003 0.0011
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0105 0.0348 0.1189
Loa Loa (eye worm) intermediate filament protein 0.0086 0.0269 0.0919
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0105 0.0348 0.0348
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0105 0.0348 0.1189
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0196 0.0718 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0061 0.0218
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0078 0.0239 1
Loa Loa (eye worm) hypothetical protein 0.0097 0.0316 0.1079
Schistosoma mansoni DNA ligase IV 0.004 0.0084 0.0287
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.004 0.0084 0.1171
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0124 0.0424 0.1447
Onchocerca volvulus 0.0097 0.0316 0.0815
Onchocerca volvulus 0.0142 0.0499 0.1458
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0036 0.0066 0.0066
Trichomonas vaginalis conserved hypothetical protein 0.0132 0.0457 1
Schistosoma mansoni ran 0.0022 0.0009 0.0031
Brugia malayi hypothetical protein 0.0055 0.0146 0.05
Onchocerca volvulus Protein ultraspiracle homolog 0.0105 0.0348 0.0928
Echinococcus granulosus lamin dm0 0.0086 0.0269 0.1243
Schistosoma mansoni hypothetical protein 0.0036 0.0066 0.0224
Loa Loa (eye worm) hypothetical protein 0.0135 0.0472 0.1612
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.011 0.0375
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0055 0.0146 0.0676
Echinococcus granulosus survival motor neuron protein 1 0.0505 0.1974 0.9124
Brugia malayi orphan nuclear receptor NR2E1 0.005 0.0122 0.0417
Echinococcus granulosus neurogenic locus notch protein 0.0072 0.0213 0.0987
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0135 0.0472 0.1612
Schistosoma mansoni notch 0.0072 0.0213 0.0729
Echinococcus multilocularis laminin 0.0135 0.0472 0.0472
Schistosoma mansoni dock 0.0081 0.025 0.0854
Echinococcus granulosus neuropeptide s receptor 0.0468 0.1824 0.8433
Mycobacterium tuberculosis Conserved protein 0.011 0.0368 0.1324
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0003 0.0045
Echinococcus multilocularis dnaJ subfamily B 0.0414 0.1604 0.1604
Onchocerca volvulus 0.0142 0.0499 0.1458
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0316 0.1205 0.4118
Brugia malayi hypothetical protein 0.004 0.0084 0.0287
Plasmodium falciparum cysteine repeat modular protein 1 0.0196 0.0718 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0061 0.0218
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0105 0.0348 0.0928
Onchocerca volvulus 0.0097 0.0316 0.0815
Loa Loa (eye worm) hypothetical protein 0.011 0.0368 0.1258
Brugia malayi hypothetical protein 0.0505 0.1974 0.6745
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0003 0.0071
Toxoplasma gondii PAN domain-containing protein 0.0097 0.0316 0.0759
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0142 0.0499 0.2305
Entamoeba histolytica hypothetical protein 0.0147 0.0521 0.4446
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0084 0.184
Onchocerca volvulus 0.0072 0.0213 0.0455
Schistosoma mansoni thyroid hormone receptor 0.0105 0.0348 0.1189
Loa Loa (eye worm) hypothetical protein 0.0036 0.0066 0.0224
Echinococcus granulosus neural cadherin 0.0072 0.0213 0.0987
Trichomonas vaginalis esterase, putative 0.011 0.0368 0.8055
Echinococcus multilocularis Coagulation factor 5 8 type, C terminal 0.0081 0.025 0.025
Toxoplasma gondii microneme protein MIC4 0.0097 0.0316 0.0759
Brugia malayi hypothetical protein 0.0142 0.0499 0.1704
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0003 0.0088
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0078 0.0239 0.3327
Brugia malayi RNA recognition motif domain containing protein 0.0389 0.1502 0.5133
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0003 0.0003
Onchocerca volvulus 0.0142 0.0499 0.1458
Onchocerca volvulus 0.0105 0.0348 0.0928
Loa Loa (eye worm) hypothetical protein 0.005 0.0122 0.0417
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.005 0.0122 0.0122
Schistosoma mansoni tar DNA-binding protein 0.0389 0.1502 0.5133
Brugia malayi Calcitonin receptor-like protein seb-1 0.0113 0.0379 0.1296
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0105 0.0348 0.0348
Brugia malayi Cytochrome P450 family protein 0.0026 0.0028 0.0096
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0142 0.0499 0.0499
Echinococcus multilocularis peptidase Clp (S14 family) 0.0051 0.0129 0.0129
Echinococcus multilocularis glycoprotein Antigen 5 0.0228 0.0848 0.0848
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0122 0.1706
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0009 0.0031
Schistosoma mansoni nuclear hormone receptor 0.0105 0.0348 0.1189
Loa Loa (eye worm) hypothetical protein 0.0072 0.0213 0.0729
Echinococcus granulosus nibrin 0.004 0.0084 0.0389
Schistosoma mansoni hypothetical protein 0.0196 0.0718 0.2452
Echinococcus multilocularis neural cadherin 0.0072 0.0213 0.0213
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0051 0.0129 0.0464
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0078 0.0239 0.5723
Loa Loa (eye worm) PAN domain-containing protein 0.0097 0.0316 0.1079
Loa Loa (eye worm) hypothetical protein 0.011 0.0368 0.1258
Brugia malayi Trypsin family protein 0.0142 0.0499 0.1704
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.004 0.0084 0.184
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0132 0.0457 0.1561
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0105 0.0347 0.1249
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.004 0.0084 0.1686
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0105 0.0348 0.1189
Echinococcus multilocularis protein jagged 1 0.0072 0.0213 0.0213
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0105 0.0348 0.1189
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0105 0.0348 0.1189
Brugia malayi Probable ClpP-like protease 0.0078 0.0239 0.0816
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0003 0.0045
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0105 0.0348 0.1608
Trichomonas vaginalis penicillin-binding protein, putative 0.011 0.0368 0.8055
Echinococcus multilocularis protein dispatched 1 0.015 0.0533 0.0533
Brugia malayi MH2 domain containing protein 0.0242 0.0905 0.3092
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.005 0.0122 0.0417
Echinococcus multilocularis tissue type plasminogen activator 0.0196 0.0718 0.0718
Loa Loa (eye worm) hypothetical protein 0.0739 0.2927 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0003 0.0088
Schistosoma mansoni septate junction protein 0.0085 0.0266 0.0908
Loa Loa (eye worm) hypothetical protein 0.005 0.0122 0.0417
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.004 0.0084 0.3521
Echinococcus multilocularis transmembrane protease serine 3 0.0142 0.0499 0.0499
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0307 0.1171 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0003 0.0028
Echinococcus multilocularis neurogenic locus notch protein 0.0072 0.0213 0.0213
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.004 0.0084 0.2284
Loa Loa (eye worm) hypothetical protein 0.005 0.0122 0.0417
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0003 0.0088
Loa Loa (eye worm) PAN domain-containing protein 0.0097 0.0316 0.1079
Echinococcus multilocularis Niemann Pick C1 protein 0.0307 0.1171 0.1171
Trichomonas vaginalis replication factor C large subunit, putative 0.004 0.0084 0.184
Loa Loa (eye worm) RNA binding protein 0.0389 0.1502 0.5133
Brugia malayi nuclear hormone receptor 0.005 0.0122 0.0417
Brugia malayi GCC2 and GCC3 family protein 0.0072 0.0213 0.0729
Loa Loa (eye worm) hypothetical protein 0.0072 0.0213 0.0729
Onchocerca volvulus 0.0097 0.0316 0.0815
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0105 0.0347 0.1249
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0003 0.0011
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0003 0.0088
Echinococcus multilocularis neurogenic locus protein delta 0.0072 0.0213 0.0213
Mycobacterium ulcerans hypothetical protein 0.0142 0.0499 1
Brugia malayi PAN domain containing protein 0.0097 0.0316 0.1079
Trypanosoma brucei trypanothione reductase 0.0046 0.0108 0.2921
Toxoplasma gondii kringle domain-containing protein 0.0196 0.0718 0.1725
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0051 0.0129 0.0464
Brugia malayi CXXC zinc finger family protein 0.0058 0.0158 0.0539
Schistosoma mansoni hypothetical protein 0.0551 0.2163 0.7392
Echinococcus granulosus delta-like protein 1 0.0072 0.0213 0.0987
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0003 0.0045
Loa Loa (eye worm) hypothetical protein 0.0072 0.0213 0.0729
Echinococcus granulosus protein jagged 2 0.0072 0.0213 0.0987
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0105 0.0348 0.1189
Brugia malayi hypothetical protein 0.0055 0.0146 0.05
Brugia malayi Cadherin domain containing protein 0.0072 0.0213 0.0729
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0078 0.0239 0.0239
Loa Loa (eye worm) PAN domain-containing protein 0.0097 0.0316 0.1079
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0009 0.0022
Loa Loa (eye worm) hypothetical protein 0.0036 0.0069 0.0235
Brugia malayi PAN domain containing protein 0.0097 0.0316 0.1079
Mycobacterium ulcerans esterase/lipase LipP 0.011 0.0368 0.7382
Schistosoma mansoni intermediate filament proteins 0.0086 0.0269 0.0919
Brugia malayi nuclear hormone receptor 0.0105 0.0348 0.1189
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0105 0.0347 0.8694
Echinococcus granulosus Nuclear hormone receptor HR96 0.005 0.0122 0.0564
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0084 0.1171
Leishmania major hypothetical protein, conserved 0.011 0.0368 0.5128
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0046 0.0107 0.0366
Brugia malayi Nuclear hormone receptor-like 1 0.0055 0.0146 0.05
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0389 0.1502 0.5133
Loa Loa (eye worm) hypothetical protein 0.0072 0.0213 0.0729
Brugia malayi hypothetical protein 0.004 0.0084 0.0287
Loa Loa (eye worm) hypothetical protein 0.0072 0.0213 0.0729
Loa Loa (eye worm) hypothetical protein 0.005 0.0122 0.0417
Schistosoma mansoni hypothetical protein 0.0022 0.0011 0.0038
Echinococcus multilocularis importin subunit beta 1 0.003 0.0041 0.0041
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.011 0.0508
Echinococcus granulosus protein jagged 2 0.0072 0.0213 0.0987
Mycobacterium ulcerans lipase LipD 0.011 0.0368 0.7382
Loa Loa (eye worm) PAN domain-containing protein 0.0097 0.0316 0.1079
Trichomonas vaginalis penicillin-binding protein, putative 0.011 0.0368 0.8055
Echinococcus granulosus intermediate filament protein 0.0086 0.0269 0.1243
Loa Loa (eye worm) glutathione reductase 0.0046 0.0108 0.0367
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0003 0.0015
Plasmodium falciparum glutathione reductase 0.0046 0.0108 0.1498
Onchocerca volvulus 0.011 0.0368 0.0999
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0105 0.0348 0.0348
Brugia malayi Calcium binding EGF domain containing protein 0.0072 0.0213 0.0729
Toxoplasma gondii PAN domain-containing protein 0.0097 0.0316 0.0759
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0086 0.0269 0.0919
Loa Loa (eye worm) hypothetical protein 0.005 0.0122 0.0417
Loa Loa (eye worm) hypothetical protein 0.0072 0.0213 0.0729
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0105 0.0348 0.1608
Schistosoma mansoni hypothetical protein 0.0127 0.0438 0.1495
Echinococcus granulosus protein jagged 1 0.0072 0.0213 0.0987
Brugia malayi Trypsin family protein 0.0739 0.2927 1
Echinococcus multilocularis dna polymerase kappa 0.002 0.0003 0.0003
Schistosoma mansoni importin beta-1 0.003 0.0041 0.0139
Schistosoma mansoni cpg binding protein 0.0058 0.0158 0.0539
Loa Loa (eye worm) hypothetical protein 0.0072 0.0213 0.0729
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.004 0.0084 0.0202
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0022 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0097 0.0316 0.1079
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0003 0.0088
Schistosoma mansoni topbp1 0.004 0.0084 0.0287
Schistosoma mansoni notch 0.0072 0.0213 0.0729
Brugia malayi EGF-like domain containing protein 0.0072 0.0213 0.0729
Loa Loa (eye worm) hypothetical protein 0.0036 0.0069 0.0235
Schistosoma mansoni cercarial elastase (S01 family) 0.0142 0.0499 0.1704
Loa Loa (eye worm) hypothetical protein 0.0105 0.0348 0.1189
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0003 0.0011
Loa Loa (eye worm) hypothetical protein 0.0307 0.1171 0.4
Echinococcus multilocularis fibropellin Ia 0.0072 0.0213 0.0213
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.004 0.0084 0.184
Loa Loa (eye worm) hypothetical protein 0.0072 0.0213 0.0729
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0049 0.0119 0.2384
Toxoplasma gondii PAN/Apple domain-containing protein 0.0097 0.0316 0.0759
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0078 0.0239 0.1104
Loa Loa (eye worm) hypothetical protein 0.0135 0.0472 0.1612
Onchocerca volvulus 0.0049 0.0119 0.0122
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0214 0.079 0.079
Echinococcus multilocularis geminin 0.0551 0.2163 0.2163
Loa Loa (eye worm) hypothetical protein 0.0142 0.0499 0.1704
Toxoplasma gondii microneme protein MIC17A 0.0097 0.0316 0.0759
Onchocerca volvulus 0.0072 0.0213 0.0455
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0018 0.0394
Brugia malayi Calcium binding EGF domain containing protein 0.0072 0.0213 0.0729
Brugia malayi AMP-binding enzyme family protein 0.0049 0.0119 0.0406
Echinococcus multilocularis fibrillin 1 0.0135 0.0472 0.0472
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.011 0.0368 0.1324
Echinococcus granulosus FTZ F1 alpha 0.0105 0.0348 0.1608
Brugia malayi nuclear receptor NHR-88 0.005 0.0122 0.0417
Entamoeba histolytica acyl-CoA synthetase, putative 0.0049 0.0119 0.1016
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0105 0.0348 0.1189
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0108 0.1498
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.011 0.0368 0.7382
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0078 0.0239 0.3327
Brugia malayi Calcium binding EGF domain containing protein 0.0135 0.0472 0.1612
Echinococcus multilocularis slit 2 protein 0.0072 0.0213 0.0213
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0072 0.0213 0.0729
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0105 0.0348 0.1189
Loa Loa (eye worm) hypothetical protein 0.0049 0.0119 0.0406
Echinococcus multilocularis neurogenic locus notch protein 0.0072 0.0213 0.0213
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0084 0.184
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0739 0.2927 1
Schistosoma mansoni laminin gamma-3 chain 0.0072 0.0213 0.0729
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0142 0.0499 0.1704
Loa Loa (eye worm) hypothetical protein 0.0105 0.0348 0.1189
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0003 0.0088
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0142 0.0499 0.1704
Echinococcus granulosus Niemann Pick C1 protein 0.0439 0.1707 0.7891
Loa Loa (eye worm) hypothetical protein 0.0072 0.0213 0.0729
Brugia malayi nuclear receptor RXR 0.0055 0.0146 0.05
Echinococcus granulosus Tolloid protein 1 0.0135 0.0472 0.218
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.011 0.0375
Brugia malayi Pax transcription activation domain interacting protein 0.004 0.0084 0.0287
Echinococcus multilocularis fat cadherin tumor suppressor 0.0072 0.0213 0.0213
Trichomonas vaginalis ran, putative 0.0022 0.0009 0.0197
Loa Loa (eye worm) hypothetical protein 0.0086 0.0269 0.0919
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0041 0.0089 0.041
Schistosoma mansoni notch 0.0072 0.0213 0.0729
Brugia malayi Trypsin family protein 0.0142 0.0499 0.1704
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0003 0.0045
Echinococcus multilocularis ecdysone induced protein 78C 0.0105 0.0348 0.0348
Echinococcus multilocularis enteropeptidase 0.0228 0.0848 0.0848
Loa Loa (eye worm) hypothetical protein 0.005 0.0122 0.0417
Onchocerca volvulus 0.0739 0.2927 1
Brugia malayi EGF-like domain containing protein 0.0072 0.0213 0.0729
Brugia malayi nuclear receptor NHR-67 0.005 0.0122 0.0417
Loa Loa (eye worm) hypothetical protein 0.0113 0.0379 0.1296
Echinococcus granulosus transmembrane protease serine 3 0.0142 0.0499 0.2305
Echinococcus multilocularis nuclear receptor nhr 48 0.005 0.0122 0.0122
Loa Loa (eye worm) hypothetical protein 0.005 0.0122 0.0417
Loa Loa (eye worm) nuclear receptor NHR-67 0.005 0.0122 0.0417
Echinococcus multilocularis neuropeptide receptor A26 0.0468 0.1824 0.1824
Mycobacterium leprae conserved hypothetical protein 0.011 0.0368 0.9266
Trichomonas vaginalis D-aminoacylase, putative 0.011 0.0368 0.8055
Toxoplasma gondii hypothetical protein 0.0097 0.0316 0.0759
Brugia malayi photoreceptor-specific nuclear receptor 0.0105 0.0348 0.1189
Onchocerca volvulus 0.0103 0.0339 0.0898
Schistosoma mansoni cell polarity protein 0.0072 0.0213 0.0729
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0051 0.0129 0.2715
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.011 0.0368 0.1258
Onchocerca volvulus 0.0086 0.0269 0.065
Loa Loa (eye worm) hypothetical protein 0.0072 0.0213 0.0729
Loa Loa (eye worm) nuclear receptor nhr-7B 0.005 0.0122 0.0417
Loa Loa (eye worm) hypothetical protein 0.0505 0.1974 0.6745
Entamoeba histolytica acyl-coA synthetase, putative 0.0049 0.0119 0.1016
Echinococcus granulosus protein jagged 1 0.0072 0.0213 0.0987
Schistosoma mansoni tar DNA-binding protein 0.0389 0.1502 0.5133
Loa Loa (eye worm) hypothetical protein 0.004 0.0084 0.0287
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0084 0.184
Giardia lamblia Replication factor C, subunit 1 0.004 0.0084 0.3939
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0122 0.1706
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0105 0.0348 0.1189
Schistosoma mansoni hypothetical protein 0.0103 0.0339 0.1159
Toxoplasma gondii PAN domain-containing protein 0.1042 0.4162 1
Loa Loa (eye worm) hypothetical protein 0.011 0.0368 0.1258
Loa Loa (eye worm) hypothetical protein 0.0072 0.0213 0.0729
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0084 0.184
Brugia malayi RNA, U transporter 1 0.0084 0.0263 0.0897
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0009 0.0042
Mycobacterium tuberculosis Probable dehydrogenase 0.0105 0.0347 0.1249
Plasmodium vivax glutathione reductase, putative 0.0046 0.0108 0.1498
Schistosoma mansoni cercarial elastase (S01 family) 0.0142 0.0499 0.1704
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.005 0.0122 0.0417
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0105 0.0348 0.1189
Loa Loa (eye worm) hypothetical protein 0.0072 0.0213 0.0729
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0105 0.0348 0.1189
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0105 0.0348 0.1608
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.0119 0.1656
Leishmania major DNA polymerase eta, putative 0.002 0.0003 0.0045
Loa Loa (eye worm) hypothetical protein 0.0132 0.0457 0.1561
Plasmodium vivax replication factor C subunit 1, putative 0.004 0.0084 0.1171
Leishmania major GTP-binding protein, putative 0.0022 0.0009 0.0125
Echinococcus multilocularis Nuclear hormone receptor HR96 0.005 0.0122 0.0122
Echinococcus granulosus notch 0.0072 0.0213 0.0987
Toxoplasma gondii microneme protein MIC17C 0.0097 0.0316 0.0759
Echinococcus multilocularis thyroid hormone receptor alpha 0.0105 0.0348 0.0348
Schistosoma mansoni nuclear receptor 0.005 0.0122 0.0417
Plasmodium vivax hypothetical protein, conserved 0.011 0.0368 0.5128
Echinococcus granulosus tar DNA binding protein 0.0389 0.1502 0.6943
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0009 0.0009
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.005 0.0122 0.0122
Echinococcus granulosus geminin 0.0551 0.2163 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0082 0.0281
Echinococcus multilocularis lamin dm0 0.0086 0.0269 0.0269
Schistosoma mansoni hypothetical protein 0.0036 0.0066 0.0224
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0105 0.0348 0.1189
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0003 0.0088
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0084 0.1171
Plasmodium vivax acyl-CoA synthetase, putative 0.0036 0.0069 0.0957
Onchocerca volvulus 0.0142 0.0499 0.1458
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0072 0.0213 0.0729
Schistosoma mansoni cercarial elastase (S01 family) 0.0142 0.0499 0.1704
Brugia malayi intermediate filament protein 0.0086 0.0269 0.0919
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0105 0.0348 0.1608
Schistosoma mansoni lamin 0.0086 0.0269 0.0919
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0027 0.003 0.1261
Toxoplasma gondii PAN domain-containing protein 0.0097 0.0316 0.0759
Brugia malayi nuclear hormone receptor family member nhr-6 0.005 0.0122 0.0417
Trypanosoma brucei PAB1-binding protein , putative 0.005 0.0122 0.3328
Mycobacterium tuberculosis Probable oxidoreductase 0.0117 0.0395 0.142
Loa Loa (eye worm) hypothetical protein 0.004 0.0084 0.0287
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0018 0.0394
Mycobacterium tuberculosis Probable hydrolase 0.011 0.0368 0.1324
Echinococcus multilocularis notch 0.0072 0.0213 0.0213
Loa Loa (eye worm) hypothetical protein 0.004 0.0084 0.0287
Brugia malayi Intermediate filament tail domain containing protein 0.0086 0.0269 0.0919
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0003 0.0071
Trypanosoma cruzi FHA domain containing protein, putative 0.004 0.0084 0.1171
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0078 0.0239 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0147 0.0521 0.2406
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.011 0.0508
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0055 0.0146 0.05
Brugia malayi EGF-like domain containing protein 0.0072 0.0213 0.0729
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.011 0.0368 0.1258
Schistosoma mansoni hypothetical protein 0.0072 0.0213 0.0729
Brugia malayi hypothetical protein 0.005 0.0122 0.0418
Schistosoma mansoni peptidase Clp (S14 family) 0.0078 0.0239 0.0816
Onchocerca volvulus 0.0142 0.0499 0.1458
Echinococcus multilocularis Nuclear hormone receptor HR96 0.005 0.0122 0.0122
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0018 0.0251
Brugia malayi TAR-binding protein 0.0389 0.1502 0.5133
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0022 0.0011 0.0051
Brugia malayi notch-like transmembrane receptor 0.0072 0.0213 0.0729
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0078 0.0239 0.479
Loa Loa (eye worm) Notch2 0.0072 0.0213 0.0729
Schistosoma mansoni hypothetical protein 0.0036 0.0066 0.0224
Loa Loa (eye worm) hypothetical protein 0.011 0.0368 0.1258
Schistosoma mansoni hypothetical protein 0.0316 0.1205 0.4118
Schistosoma mansoni survival motor neuron protein 0.0103 0.0339 0.1159
Trichomonas vaginalis D-aminoacylase, putative 0.011 0.0368 0.8055
Schistosoma mansoni DNA polymerase eta 0.002 0.0003 0.0011
Echinococcus granulosus Niemann Pick C1 protein 0.0307 0.1171 0.5411
Entamoeba histolytica hypothetical protein 0.0147 0.0521 0.4446
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0228 0.0848 0.2897
Echinococcus granulosus nuclear receptor nhr 48 0.005 0.0122 0.0564
Loa Loa (eye worm) PAN domain-containing protein 0.0097 0.0316 0.1079
Echinococcus granulosus dna polymerase eta 0.002 0.0003 0.0015
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0036 0.0066 0.0224
Echinococcus granulosus nuclear receptor 2DBD gamma 0.005 0.0122 0.0564
Loa Loa (eye worm) hypothetical protein 0.0049 0.0119 0.0406
Loa Loa (eye worm) hypothetical protein 0.002 0.0003 0.0011
Schistosoma mansoni hypothetical protein 0.0072 0.0213 0.0729
Brugia malayi Importin beta-1 subunit 0.003 0.0041 0.0139
Echinococcus multilocularis protein patched 0.0132 0.0457 0.0457
Loa Loa (eye worm) hypothetical protein 0.0041 0.0089 0.0303
Echinococcus granulosus tissue type plasminogen activator 0.0196 0.0718 0.3318
Echinococcus multilocularis dna polymerase eta 0.002 0.0003 0.0003
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0108 0.1498
Loa Loa (eye worm) hypothetical protein 0.0072 0.0213 0.0729
Echinococcus granulosus lamin 0.0086 0.0269 0.1243
Echinococcus granulosus ecdysone induced protein 78C 0.0105 0.0348 0.1608
Giardia lamblia High cysteine protein 0.0072 0.0213 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.011 0.0375
Toxoplasma gondii microneme protein, putative 0.0097 0.0316 0.0759
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0049 0.0119 0.2384
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0105 0.0348 0.1189
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0105 0.0348 0.1608
Echinococcus granulosus neurogenic locus notch protein 0.0072 0.0213 0.0987
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0105 0.0348 0.1189
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0049 0.0119 0.2384
Schistosoma mansoni coup transcription factor 0.0105 0.0348 0.1189
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.011 0.0368 0.1258
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0105 0.0348 0.0348
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.011 0.0375
Brugia malayi Trypsin-like protease protein 5 0.0142 0.0499 0.1704
Onchocerca volvulus 0.0097 0.0316 0.0815
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0003 0.0088
Echinococcus granulosus Nuclear hormone receptor HR96 0.005 0.0122 0.0564
Schistosoma mansoni tar DNA-binding protein 0.0389 0.1502 0.5133
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.004 0.0084 0.0287
Schistosoma mansoni notch 0.0072 0.0213 0.0729
Loa Loa (eye worm) TK/ROR protein kinase 0.0196 0.0718 0.2452
Echinococcus granulosus Coagulation factor 5 8 type C terminal 0.0081 0.025 0.1156
Brugia malayi ecdysteroid receptor 0.0105 0.0348 0.1189
Brugia malayi nuclear receptor RXR 0.005 0.0122 0.0417
Loa Loa (eye worm) hypothetical protein 0.0077 0.0234 0.08
Brugia malayi EGF-like domain containing protein 0.0072 0.0213 0.0729
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.011 0.011
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0142 0.0499 0.1704
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0003 0.0088
Echinococcus multilocularis lamin 0.0086 0.0269 0.0269
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0027 0.003 0.042
Echinococcus granulosus cpg binding protein 0.0062 0.0171 0.0791
Loa Loa (eye worm) hypothetical protein 0.0072 0.0213 0.0729
Schistosoma mansoni hypothetical protein 0.0072 0.0213 0.0729
Schistosoma mansoni topbp1 0.004 0.0084 0.0287
Loa Loa (eye worm) hypothetical protein 0.005 0.0122 0.0417
Loa Loa (eye worm) hypothetical protein 0.0072 0.0213 0.0729
Entamoeba histolytica Ran family GTPase 0.0022 0.0009 0.0077
Plasmodium falciparum acyl-CoA synthetase 0.0036 0.0069 0.0957
Mycobacterium tuberculosis Probable lipase LipD 0.011 0.0368 0.1324
Plasmodium falciparum importin beta, putative 0.003 0.0041 0.0568
Echinococcus multilocularis Tolloid protein 1 0.0135 0.0472 0.0472
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0108 0.0387
Brugia malayi Delta serrate ligand family protein 0.0072 0.0213 0.0729
Toxoplasma gondii thioredoxin reductase 0.0046 0.0108 0.0258
Echinococcus multilocularis Mastin 0.0228 0.0848 0.0848
Echinococcus granulosus laminin 0.0135 0.0472 0.218
Loa Loa (eye worm) hypothetical protein 0.0739 0.2927 1
Treponema pallidum DNA ligase (lig) 0.004 0.0084 0.3521
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0147 0.0521 0.0521
Brugia malayi PAN domain containing protein 0.0097 0.0316 0.1079
Brugia malayi conserved hypotetical protein 0.005 0.0122 0.0417
Toxoplasma gondii microneme protein MIC17B 0.0097 0.0316 0.0759
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0084 0.184
Echinococcus multilocularis nibrin 0.004 0.0084 0.0084
Loa Loa (eye worm) hypothetical protein 0.0072 0.0213 0.0729
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0049 0.0119 0.0428
Loa Loa (eye worm) hypothetical protein 0.004 0.0084 0.0287
Onchocerca volvulus 0.0097 0.0316 0.0815
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0049 0.0119 0.2434
Loa Loa (eye worm) hypothetical protein 0.0072 0.0213 0.0729
Toxoplasma gondii hypothetical protein 0.0027 0.003 0.0072
Loa Loa (eye worm) TAR-binding protein 0.0389 0.1502 0.5133
Echinococcus multilocularis snurportin 1 0.0316 0.1205 0.1205
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0036 0.0066 0.0303
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0003 0.0065
Loa Loa (eye worm) hypothetical protein 0.0105 0.0348 0.1189
Brugia malayi EGF-like domain containing protein 0.0072 0.0213 0.0729
Mycobacterium leprae Probable lipase LipE 0.011 0.0368 0.9266
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0105 0.0348 0.1189
Schistosoma mansoni cercarial elastase (S01 family) 0.0142 0.0499 0.1704
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0142 0.0499 0.1704
Onchocerca volvulus Slit protein homolog 0.0072 0.0213 0.0455
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.004 0.0084 0.184
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0009 0.0125
Schistosoma mansoni cercarial elastase (S01 family) 0.0142 0.0499 0.1704
Toxoplasma gondii ATPase, AAA family protein 0.004 0.0084 0.0202
Loa Loa (eye worm) hypothetical protein 0.0105 0.0348 0.1189
Echinococcus multilocularis sterol regulatory element binding protein 0.0132 0.0457 0.0457
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0078 0.0239 0.0574
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0061 0.0218
Loa Loa (eye worm) trypsin family protein 0.0142 0.0499 0.1704
Loa Loa (eye worm) hypothetical protein 0.0142 0.0499 0.1704
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0312 0.119 0.4066
Loa Loa (eye worm) hypothetical protein 0.011 0.0368 0.1258
Loa Loa (eye worm) hypothetical protein 0.0055 0.0146 0.05
Schistosoma mansoni steroid hormone receptor ad4bp 0.0105 0.0348 0.1189
Loa Loa (eye worm) hypothetical protein 0.0164 0.0588 0.2009
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0122 0.1706
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0009 0.0125
Loa Loa (eye worm) latrophilin receptor protein 2 0.0036 0.0066 0.0224
Echinococcus multilocularis expressed conserved protein 0.0289 0.1095 0.1095
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0003 0.0088
Echinococcus granulosus dna polymerase kappa 0.002 0.0003 0.0015
Loa Loa (eye worm) steroid hormone receptor 0.0105 0.0348 0.1189
Echinococcus multilocularis musashi 0.0086 0.0269 0.0269
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0049 0.0119 0.2434
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.005 0.0122 0.0122
Leishmania major trypanothione reductase 0.0046 0.0108 0.1498
Loa Loa (eye worm) hypothetical protein 0.0078 0.0239 0.0816
Brugia malayi cytoplasmic intermediate filament protein 0.0046 0.0107 0.0366
Loa Loa (eye worm) hypothetical protein 0.0142 0.0499 0.1704
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.004 0.0084 0.184
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0122 0.1706
Onchocerca volvulus 0.0097 0.0316 0.0815
Schistosoma mansoni zinc finger protein 0.005 0.0122 0.0417
Schistosoma mansoni hypothetical protein 0.0036 0.0066 0.0224
Echinococcus multilocularis cpg binding protein 0.0062 0.0171 0.0171
Brugia malayi DKFZp564C0469 protein 0.004 0.0084 0.0287
Trypanosoma cruzi hypothetical protein, conserved 0.011 0.0368 0.5128
Schistosoma mansoni thyroid hormone receptor 0.0105 0.0348 0.1189
Brugia malayi topoisomerase 0.004 0.0084 0.0287
Trypanosoma brucei unspecified product 0.002 0.0003 0.0088
Brugia malayi Muscle positioning protein 4 0.0072 0.0213 0.0729
Schistosoma mansoni hypothetical protein 0.0147 0.0521 0.1779
Loa Loa (eye worm) hypothetical protein 0.005 0.0122 0.0417
Schistosoma mansoni hypothetical protein 0.0551 0.2163 0.7392
Toxoplasma gondii calcium binding egf domain-containing protein 0.0135 0.0472 0.1133
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0117 0.0395 1
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0055 0.0146 0.0146
Onchocerca volvulus 0.0097 0.0316 0.0815
Loa Loa (eye worm) hypothetical protein 0.0097 0.0316 0.1079
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0036 0.0066 0.0303
Loa Loa (eye worm) hypothetical protein 0.0084 0.0263 0.0897
Brugia malayi CHE-14 protein 0.0132 0.0457 0.1561
Schistosoma mansoni cpg binding protein 0.0062 0.0171 0.0585
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0018 0.0394
Echinococcus granulosus neuropeptide receptor A26 0.0468 0.1824 0.8433
Trypanosoma brucei hypothetical protein, conserved 0.011 0.0368 1
Leishmania major hypothetical protein, conserved 0.005 0.0122 0.1706
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0049 0.0119 0.2384
Schistosoma mansoni chromosome transmission fidelity factor 0.004 0.0084 0.0287
Loa Loa (eye worm) hypothetical protein 0.0072 0.0213 0.0729
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0097 0.0316 0.0759
Onchocerca volvulus 0.0072 0.0213 0.0455
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0113 0.0379 0.1296
Loa Loa (eye worm) hypothetical protein 0.0105 0.0348 0.1189
Schistosoma mansoni cercarial elastase (S01 family) 0.0142 0.0499 0.1704
Echinococcus granulosus Protein patched homolog 1 0.0132 0.0457 0.2112
Echinococcus granulosus GPCR family 2 0.0036 0.0066 0.0303
Schistosoma mansoni cercarial elastase (S01 family) 0.0142 0.0499 0.1704
Brugia malayi PAN domain containing protein 0.0097 0.0316 0.1079
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0113 0.0379 0.1296
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0036 0.0066 0.0066
Onchocerca volvulus 0.0058 0.0158 0.0259
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0003 0.0045
Toxoplasma gondii hypothetical protein 0.0097 0.0316 0.0759
Plasmodium vivax ataxin-2 like protein, putative 0.005 0.0122 0.1706
Loa Loa (eye worm) hypothetical protein 0.0049 0.0119 0.0406
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0703 0.278 1
Toxoplasma gondii subtilisin SUB12 0.0097 0.0316 0.0759
Schistosoma mansoni nuclear receptor 0.005 0.0122 0.0417
Schistosoma mansoni notch 0.0072 0.0213 0.0729
Brugia malayi Calcium binding EGF domain containing protein 0.0072 0.0213 0.0729
Brugia malayi hypothetical protein 0.0147 0.0521 0.1779
Plasmodium falciparum thioredoxin reductase 0.0046 0.0108 0.1498
Onchocerca volvulus 0.011 0.0368 0.0999
Echinococcus multilocularis survival motor neuron protein 1 0.0505 0.1974 0.1974
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0009 0.0244
Mycobacterium tuberculosis Probable lipase LipE 0.011 0.0368 0.1324
Onchocerca volvulus 0.0086 0.0269 0.065
Toxoplasma gondii EGF family domain-containing protein 0.0072 0.0213 0.0513
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0049 0.0119 0.0428
Brugia malayi Nuclear hormone receptor E75 0.005 0.0122 0.0417
Onchocerca volvulus 0.0097 0.0316 0.0815
Onchocerca volvulus Neurogenic locus notch homolog 0.0072 0.0213 0.0455
Echinococcus multilocularis replication factor c subunit 1 0.004 0.0084 0.0084
Loa Loa (eye worm) hypothetical protein 0.0105 0.0348 0.1189
Toxoplasma gondii calcium binding egf domain-containing protein 0.0135 0.0472 0.1133
Schistosoma mansoni hypothetical protein 0.0142 0.0499 0.1704
Echinococcus granulosus neurogenic locus protein delta 0.0072 0.0213 0.0987
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.011 0.0368 0.1324
Plasmodium falciparum replication factor C subunit 1, putative 0.004 0.0084 0.1171
Schistosoma mansoni hypothetical protein 0.0072 0.0213 0.0729
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0003 0.0065
Schistosoma mansoni ran 0.0022 0.0009 0.0031
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0078 0.0239 1
Leishmania major DNA polymerase kappa, putative 0.002 0.0003 0.0045
Leishmania major importin beta-1 subunit, putative 0.0024 0.0018 0.0251
Loa Loa (eye worm) hypothetical protein 0.0142 0.0499 0.1704
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0105 0.0348 0.1189
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.005 0.0122 0.0564
Brugia malayi tailless protein 0.005 0.0122 0.0417
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0061 0.0218
Loa Loa (eye worm) hypothetical protein 0.0162 0.0578 0.1974
Mycobacterium ulcerans hypothetical protein 0.011 0.0368 0.7382
Toxoplasma gondii ABC1 family protein 0.011 0.0368 0.0884
Loa Loa (eye worm) notch protein 0.0072 0.0213 0.0729
Onchocerca volvulus 0.011 0.0368 0.0999
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0214 0.079 0.3649
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0135 0.0472 0.1612
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.011 0.0375
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0105 0.0348 0.1189
Toxoplasma gondii PAN domain-containing protein 0.1042 0.4162 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0105 0.0348 0.1189
Brugia malayi latrophilin 2 splice variant baaae 0.0077 0.0234 0.08
Toxoplasma gondii LsmAD domain-containing protein 0.005 0.0122 0.0294
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0003 0.0088
Loa Loa (eye worm) hypothetical protein 0.0055 0.0146 0.05
Echinococcus granulosus enteropeptidase 0.0228 0.0848 0.3919
Loa Loa (eye worm) hypothetical protein 0.0135 0.0472 0.1612
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0117 0.0395 0.142
Brugia malayi AMP-binding enzyme family protein 0.0049 0.0119 0.0406
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0117 0.0395 0.142
Onchocerca volvulus 0.0097 0.0316 0.0815
Brugia malayi Cadherin domain containing protein 0.0072 0.0213 0.0729
Onchocerca volvulus Bile acid receptor homolog 0.0105 0.0348 0.0928
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0105 0.0348 0.1189
Schistosoma mansoni notch 0.0072 0.0213 0.0729
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0103 0.0339 0.1159
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0003 0.0045
Mycobacterium tuberculosis Probable reductase 0.0105 0.0347 0.1249
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0105 0.0348 0.0348
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0036 0.0069 0.1378
Brugia malayi PAN domain containing protein 0.0097 0.0316 0.1079
Echinococcus granulosus slit 2 protein 0.0072 0.0213 0.0987
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0055 0.0146 0.05
Loa Loa (eye worm) hypothetical protein 0.0105 0.0348 0.1189
Echinococcus granulosus Mastin 0.0228 0.0848 0.3919
Schistosoma mansoni hypothetical protein 0.0127 0.0438 0.1495
Schistosoma mansoni tar DNA-binding protein 0.0389 0.1502 0.5133
Brugia malayi Nuclear hormone receptor-like 1 0.0055 0.0146 0.05
Schistosoma mansoni hypothetical protein 0.0072 0.0213 0.0729
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0009 0.0125
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0078 0.0239 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0003 0.0012
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0072 0.0213 0.0455
Entamoeba histolytica hypothetical protein 0.0024 0.0018 0.0154
Mycobacterium ulcerans hypothetical protein 0.0049 0.0119 0.2384
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0739 0.2927 1
Brugia malayi PAN domain containing protein 0.0097 0.0316 0.1079
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0027 0.003 0.042
Echinococcus granulosus thyroid hormone receptor alpha 0.005 0.0122 0.0564
Brugia malayi steroid hormone receptor 0.0105 0.0348 0.1189
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0105 0.0347 0.1249
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0009 0.0421
Echinococcus granulosus neurogenic locus notch protein 4 0.0072 0.0213 0.0987
Loa Loa (eye worm) hypothetical protein 0.004 0.0084 0.0287
Echinococcus granulosus glycoprotein Antigen 5 0.0228 0.0848 0.3919
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.004 0.0084 0.148
Schistosoma mansoni RAR-like nuclear receptor 0.0105 0.0348 0.1189
Giardia lamblia DINP protein human, muc B family 0.002 0.0003 0.0151
Brugia malayi Niemann-Pick C1 protein precursor 0.0307 0.1171 0.4
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0105 0.0348 0.1189
Entamoeba histolytica acyl-CoA synthetase, putative 0.0049 0.0119 0.1016
Brugia malayi EGF-like domain containing protein 0.0072 0.0213 0.0729
Echinococcus granulosus snurportin 1 0.0316 0.1205 0.5571
Loa Loa (eye worm) nuclear hormone receptor 0.0158 0.0564 0.1926
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0009 0.0125
Brugia malayi beta-lactamase 0.011 0.0368 0.1258
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0105 0.0348 0.1189
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0135 0.0472 0.1612
Schistosoma mansoni cercarial elastase (S01 family) 0.0142 0.0499 0.1704
Schistosoma mansoni hypothetical protein 0.0127 0.0438 0.1495
Brugia malayi PAN domain containing protein 0.0097 0.0316 0.1079
Echinococcus granulosus sterol regulatory element binding protein 0.0132 0.0457 0.2112
Loa Loa (eye worm) hypothetical protein 0.005 0.0122 0.0418
Trypanosoma cruzi hypothetical protein, conserved 0.0196 0.0718 1
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0003 0.0011
Mycobacterium tuberculosis Conserved protein 0.011 0.0368 0.1324
Echinococcus granulosus replication factor c subunit 1 0.004 0.0084 0.0389
Brugia malayi Fibulin-1 precursor 0.0135 0.0472 0.1612
Brugia malayi nuclear hormone receptor family member odr-7 0.005 0.0122 0.0417
Brugia malayi beta-lactamase family protein 0.011 0.0368 0.1258
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.004 0.0084 0.0718
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0105 0.0348 0.1189
Entamoeba histolytica hypothetical protein 0.0147 0.0521 0.4446
Loa Loa (eye worm) hypothetical protein 0.0148 0.0524 0.179
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0041 0.0089 0.0089
Echinococcus granulosus peptidase Clp S14 family 0.0051 0.0129 0.0597
Echinococcus multilocularis neuropeptide s receptor 0.0468 0.1824 0.1824
Brugia malayi PAN domain containing protein 0.0097 0.0316 0.1079
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0135 0.0472 0.1612
Mycobacterium tuberculosis Conserved protein 0.011 0.0368 0.1324
Brugia malayi Nuclear hormone receptor-like 1 0.0105 0.0348 0.1189
Brugia malayi hypothetical protein 0.005 0.0122 0.0417
Brugia malayi EGF-like domain containing protein 0.0072 0.0213 0.0729
Entamoeba histolytica hypothetical protein 0.004 0.0084 0.0718
Echinococcus multilocularis neurogenic locus protein delta 0.0072 0.0213 0.0213
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.011 0.011
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0142 0.0499 0.0499
Schistosoma mansoni hypothetical protein 0.0142 0.0499 0.1704
Brugia malayi Nuclear hormone receptor E75 0.005 0.0122 0.0417
Loa Loa (eye worm) MH2 domain-containing protein 0.0242 0.0905 0.3092
Brugia malayi PAN domain containing protein 0.0097 0.0316 0.1079
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.0119 0.1656
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.011 0.0368 0.1258
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0105 0.0348 0.1189
Schistosoma mansoni hypothetical protein 0.0072 0.0213 0.0729
Brugia malayi Latrophilin receptor protein 2 0.0036 0.0066 0.0224
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0041 0.0098
Brugia malayi AMP-binding enzyme family protein 0.0049 0.0119 0.0406
Echinococcus granulosus expressed conserved protein 0.0289 0.1095 0.5061
Loa Loa (eye worm) hypothetical protein 0.0135 0.0472 0.1612
Loa Loa (eye worm) transcription factor SMAD2 0.0242 0.0905 0.3092
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0142 0.0499 0.2305
Loa Loa (eye worm) hypothetical protein 0.005 0.0122 0.0417
Loa Loa (eye worm) CXXC zinc finger family protein 0.0058 0.0158 0.0539
Loa Loa (eye worm) hypothetical protein 0.005 0.0122 0.0417
Loa Loa (eye worm) hypothetical protein 0.005 0.0122 0.0417
Echinococcus granulosus dnaJ subfamily B 0.0414 0.1604 0.7416
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0108 0.0367
Plasmodium vivax importin-beta 2, putative 0.003 0.0041 0.0568
Brugia malayi Steroid receptor seven-up type 2 0.0214 0.079 0.2698
Echinococcus multilocularis dedicator of cytokinesis protein 0.0068 0.0198 0.0198
Schistosoma mansoni patched 1 0.0132 0.0457 0.1561
Schistosoma mansoni hypothetical protein 0.0414 0.1604 0.5482
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.0119 0.1656
Echinococcus multilocularis protein jagged 2 0.0072 0.0213 0.0213
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0078 0.0239 0.0574
Schistosoma mansoni egf-like domain protein 0.0135 0.0472 0.1612
Schistosoma mansoni cpg binding protein 0.0062 0.0171 0.0585
Onchocerca volvulus Arrow homolog 0.0135 0.0472 0.1364
Echinococcus multilocularis protein jagged 1 0.0072 0.0213 0.0213
Schistosoma mansoni nuclear hormone receptor 0.005 0.0122 0.0417
Toxoplasma gondii histone lysine methyltransferase SET1 0.011 0.037 0.0888
Loa Loa (eye worm) hypothetical protein 0.0105 0.0348 0.1189
Loa Loa (eye worm) beta-lactamase 0.011 0.0368 0.1258
Brugia malayi hypothetical protein 0.0032 0.0051 0.0174
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0028 0.0096
Echinococcus multilocularis tar DNA binding protein 0.0389 0.1502 0.1502
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0055 0.0146 0.05
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0003 0.0011
Brugia malayi Kringle domain containing protein 0.0196 0.0718 0.2452
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.005 0.0122 0.0134
Loa Loa (eye worm) hypothetical protein 0.0072 0.0213 0.0729
Echinococcus multilocularis GPCR, family 2 0.0036 0.0066 0.0066
Schistosoma mansoni retinoic acid receptor RXR 0.0105 0.0348 0.1189
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0009 0.0031
Loa Loa (eye worm) hypothetical protein 0.004 0.0082 0.0281
Loa Loa (eye worm) hypothetical protein 0.0036 0.0069 0.0235
Schistosoma mansoni hypothetical protein 0.0077 0.0234 0.08
Loa Loa (eye worm) hypothetical protein 0.011 0.0368 0.1258
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0105 0.0348 0.1608
Onchocerca volvulus 0.0097 0.0316 0.0815
Brugia malayi nuclear receptor NHR-88 0.0105 0.0348 0.1189
Onchocerca volvulus 0.0072 0.0213 0.0455
Trypanosoma cruzi hypothetical protein, conserved 0.011 0.0368 0.5128
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0041 0.1107
Onchocerca volvulus 0.0597 0.2348 0.7966
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0108 0.0497
Schistosoma mansoni hypothetical protein 0.0072 0.0213 0.0729
Brugia malayi hypothetical protein 0.005 0.0122 0.0417
Leishmania major hypothetical protein, conserved 0.0196 0.0718 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0146 0.05
Schistosoma mansoni cercarial elastase (S01 family) 0.0142 0.0499 0.1704
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0036 0.0069 0.0247
Mycobacterium ulcerans beta-lactamase 0.011 0.0368 0.7382
Onchocerca volvulus 0.005 0.0122 0.0134
Schistosoma mansoni transcription factor LCR-F1 0.0147 0.0521 0.1779
Loa Loa (eye worm) hypothetical protein 0.0097 0.0316 0.1079
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0105 0.0348 0.1189
Brugia malayi Protein kinase domain containing protein 0.0196 0.0718 0.2452
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0003 0.0088
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0003 0.0012
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.005 0.0122 0.0417
Mycobacterium tuberculosis Probable esterase LipL 0.011 0.0368 0.1324
Schistosoma mansoni tar DNA-binding protein 0.0389 0.1502 0.5133
Mycobacterium tuberculosis Probable conserved lipoprotein 0.011 0.0368 0.1324
Brugia malayi RNA binding protein 0.0389 0.1502 0.5133
Loa Loa (eye worm) hypothetical protein 0.0072 0.0213 0.0729
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0135 0.0472 0.1612
Loa Loa (eye worm) hypothetical protein 0.003 0.0041 0.0139
Brugia malayi glutathione reductase 0.0046 0.0108 0.0367
Toxoplasma gondii PAN domain-containing protein 0.0097 0.0316 0.0759
Loa Loa (eye worm) hypothetical protein 0.0097 0.0316 0.1079
Entamoeba histolytica hypothetical protein 0.0147 0.0521 0.4446
Schistosoma mansoni cercarial elastase (S01 family) 0.0142 0.0499 0.1704
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.005 0.0122 0.0134
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0105 0.0347 0.1249
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0142 0.0499 0.1704
Echinococcus granulosus beta LACTamase domain containing family member 0.011 0.0368 0.1701
Loa Loa (eye worm) hypothetical protein 0.0196 0.0718 0.2452
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0003 0.0088
Echinococcus multilocularis Niemann Pick C1 protein 0.0439 0.1707 0.1707
Loa Loa (eye worm) hypothetical protein 0.004 0.0084 0.0287
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0119 0.2384
Echinococcus multilocularis beta LACTamase domain containing family member 0.011 0.0368 0.0368
Schistosoma mansoni slit 0.0072 0.0213 0.0729
Onchocerca volvulus 0.0097 0.0316 0.0815
Trichomonas vaginalis D-aminoacylase, putative 0.011 0.0368 0.8055
Echinococcus granulosus importin subunit beta 1 0.003 0.0041 0.0188
Loa Loa (eye worm) hypothetical protein 0.0072 0.0213 0.0729
Loa Loa (eye worm) hypothetical protein 0.0097 0.0316 0.1079
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0003 0.0088
Echinococcus multilocularis FTZ F1 alpha 0.0105 0.0348 0.0348
Brugia malayi Thioredoxin reductase 0.0046 0.0108 0.0367
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0108 0.0108
Loa Loa (eye worm) DR-78 0.005 0.0122 0.0417
Loa Loa (eye worm) hypothetical protein 0.0097 0.0316 0.1079
Schistosoma mansoni nuclear hormone receptor 0.005 0.0122 0.0417
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0119 0.2384
Brugia malayi PAN domain containing protein 0.0097 0.0316 0.1079
Schistosoma mansoni nuclear receptor nhr-48 0.005 0.0122 0.0417
Onchocerca volvulus 0.0072 0.0213 0.0455
Schistosoma mansoni lamin 0.0086 0.0269 0.0919
Brugia malayi Trypsin family protein 0.0142 0.0499 0.1704
Echinococcus multilocularis neurogenic locus notch protein 4 0.0072 0.0213 0.0213
Loa Loa (eye worm) hypothetical protein 0.0036 0.0069 0.0235
Schistosoma mansoni cercarial elastase (S01 family) 0.0142 0.0499 0.1704
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0078 0.0239 0.479
Echinococcus granulosus fibropellin Ia 0.0072 0.0213 0.0987
Onchocerca volvulus 0.005 0.0122 0.0134
Loa Loa (eye worm) hypothetical protein 0.005 0.0122 0.0417
Loa Loa (eye worm) hypothetical protein 0.0072 0.0213 0.0729
Chlamydia trachomatis DNA ligase 0.004 0.0084 0.0903
Schistosoma mansoni hypothetical protein 0.0127 0.0438 0.1495
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0041 0.1107
Loa Loa (eye worm) hypothetical protein 0.0036 0.0069 0.0235
Brugia malayi ecdysone receptor 0.005 0.0122 0.0417

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) 7.499 uM PubChem BioAssay. Luminescence-based cell-based high throughput dose response assay to identify inhibitors of COUP-TFII (NR2F2). (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) 28.481 uM PubChem BioAssay. Counterscreen for inhibitors of COUP-TFII (NR2F2): Luminescence-based cell-based high throughput dose response assay to identify inhibitors of the Herpes Virus Virion Protein 16 (VP16). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.1623 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.1623 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 4.4668 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 7.0795 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 8.1995 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 16.3601 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.3601 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.9526 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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