Detailed information for compound 1572116

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 410.595 | Formula: C11H12ClIN4O3
  • H donors: 3 H acceptors: 4 LogP: 0.36 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: NC[C@H]1OC([C@@H]([C@@H]1O)O)n1cc(c2c1ncnc2Cl)I
  • InChi: 1S/C11H12ClIN4O3/c12-9-6-4(13)2-17(10(6)16-3-15-9)11-8(19)7(18)5(1-14)20-11/h2-3,5,7-8,11,18-19H,1,14H2/t5-,7-,8-,11?/m1/s1
  • InChiKey: QATUTGXCWAHTTP-YNJARDAQSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major hypothetical protein, conserved 0.0044 0.0183 0.0546
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0044 0.0183 0.0135
Brugia malayi Unc-112 related protein. 0.0016 0.0001 0.0001
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0305 0.1908 0.6222
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0044 0.0183 0.0201
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0019 0.0018 0.0053
Echinococcus multilocularis beta adrenergic receptor kinase 0.002 0.0024 0.0025
Echinococcus granulosus jumonji domain containing 1A 0.0019 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0166 0.0991 0.1078
Treponema pallidum NADH oxidase 0.0166 0.0989 0.2465
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0166 0.0989 1
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0166 0.0989 0.3196
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0044 0.0183 0.0201
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0585 0.3753 0.6051
Plasmodium falciparum glutathione reductase 0.0479 0.3056 1
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.002 0.0022 0.0023
Trypanosoma cruzi NADH dehydrogenase, putative 0.0044 0.0183 0.0596
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0084 0.0134
Brugia malayi hypothetical protein 0.0016 0.0001 0.0001
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.01 0.0555 0.0603
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0084 0.0134
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.002 0.0022 0.0021
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0044 0.0183 0.0546
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0044 0.0183 0.0546
Toxoplasma gondii PHD-finger domain-containing protein 0.0059 0.028 0.0864
Echinococcus multilocularis peregrin 0.0059 0.028 0.0308
Schistosoma mansoni glutamate synthase 0.0044 0.0183 0.0182
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0044 0.0183 0.0294
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0044 0.0183 0.1002
Brugia malayi hypothetical protein 0.002 0.0022 0.0024
Loa Loa (eye worm) PXA domain-containing protein 0.002 0.0022 0.0023
Echinococcus granulosus beta-adrenergic receptor kinase 0.002 0.0024 0.0025
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0024 0.0048 0.0047
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0022 0.0023
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0098 0.0539 0.1716
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0022 0.0023
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0022 0.0023
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0057 0.0267 0.0293
Schistosoma mansoni regulator of G protein signaling 0.002 0.0022 0.0021
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.0603 0.1603
Loa Loa (eye worm) hypothetical protein 0.002 0.0022 0.0023
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0166 0.0989 0.1089
Plasmodium falciparum thioredoxin reductase 0.0166 0.0989 0.3196
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0044 0.0183 0.0486
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0044 0.0183 0.0546
Schistosoma mansoni protein phosphatase 2C 0.0019 0.0018 0.0016
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0057 0.0267 0.0266
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0197 0.0213
Loa Loa (eye worm) hypothetical protein 0.0067 0.0337 0.0366
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0084 0.0134
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.1093 0.711 0.8958
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0166 0.0989 0.3196
Echinococcus granulosus nuclear factor of activated T cells 5 0.0073 0.0374 0.041
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0479 0.3056 0.3716
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.1093 0.711 0.8958
Loa Loa (eye worm) ICD-1 protein 0.0035 0.0126 0.0136
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0059 0.0137
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0044 0.0183 0.02
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.012 0.0687 0.0686
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0098 0.0539 0.1716
Trypanosoma brucei hypothetical protein, conserved 0.0044 0.0183 0.0546
Trypanosoma cruzi polo-like protein kinase, putative 0.0097 0.0532 0.1736
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.1093 0.711 0.8958
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0044 0.0183 0.0201
Onchocerca volvulus 0.005 0.022 0.0352
Echinococcus multilocularis regulator of G protein signaling 0.002 0.0022 0.0023
Brugia malayi Bromodomain containing protein 0.0059 0.028 0.0305
Echinococcus multilocularis jumonji domain containing protein 0.0082 0.0432 0.0475
Trypanosoma brucei NADH dehydrogenase 0.0044 0.0183 0.0546
Plasmodium falciparum thioredoxin reductase 0.0479 0.3056 1
Loa Loa (eye worm) TK/FAK protein kinase 0.1407 0.9182 1
Schistosoma mansoni hypothetical protein 0.0019 0.0019 0.0018
Brugia malayi jmjC domain containing protein 0.0192 0.1162 0.1266
Treponema pallidum oxidoreductase 0.0044 0.0183 0.027
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.0084 0.0221
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0166 0.0989 0.0988
Schistosoma mansoni regulator of G protein signaling 0.002 0.0022 0.0021
Schistosoma mansoni rotamase 0.01 0.0555 0.0553
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0097 0.0532 0.0585
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0052 0.0238 0.0775
Brugia malayi glutathione reductase 0.0479 0.3056 0.3329
Plasmodium vivax SET domain protein, putative 0.012 0.0687 0.2205
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0057 0.0267 0.0822
Loa Loa (eye worm) hypothetical protein 0.0027 0.0069 0.0073
Echinococcus granulosus thioredoxin glutathione reductase 0.0482 0.3073 0.3387
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0166 0.0989 0.3196
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0044 0.0183 0.0294
Trypanosoma brucei DNA polymerase kappa, putative 0.0158 0.0936 0.3021
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0044 0.0183 0.027
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0126 0.0201
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0166 0.0989 1
Giardia lamblia NADH oxidase lateral transfer candidate 0.0166 0.0989 0.2465
Mycobacterium tuberculosis Probable oxidoreductase 0.1215 0.7915 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.1093 0.711 0.8958
Schistosoma mansoni DNA polymerase eta 0.0183 0.11 0.1099
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0022 0.0034
Mycobacterium tuberculosis Conserved hypothetical protein 0.0131 0.076 0.0745
Loa Loa (eye worm) glutathione reductase 0.0479 0.3056 0.3328
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0192 0.1162 0.128
Trypanosoma brucei DNA polymerase IV, putative 0.0151 0.0892 0.2877
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0047 0.0201 0.1202
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0305 0.1908 0.6243
Loa Loa (eye worm) hypothetical protein 0.0101 0.0557 0.0606
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0092 0.0502 0.1596
Brugia malayi ImpB/MucB/SamB family protein 0.0131 0.076 0.0827
Trypanosoma brucei polo-like protein kinase 0.0097 0.0532 0.1692
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0044 0.0183 0.0294
Leishmania major basic transcription factor 3a, putative 0.0035 0.0126 0.0356
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0166 0.0989 0.3196
Brugia malayi Pre-SET motif family protein 0.012 0.0687 0.0749
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0022 0.0023
Schistosoma mansoni microtubule-associated protein tau 0.138 0.9008 0.9008
Toxoplasma gondii peptidylprolyl isomerase 0.0098 0.0539 0.1716
Brugia malayi polk-prov protein 0.0067 0.0337 0.0367
Loa Loa (eye worm) RGS-3 protein 0.002 0.0022 0.0023
Brugia malayi Moesin/ezrin/radixin homolog 1 0.0016 0.0001 0.0001
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0585 0.3753 0.6051
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0047 0.0201 0.0605
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0059 0.0137
Trypanosoma brucei transcription factor BTF3, putative 0.0035 0.0126 0.0356
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0158 0.0936 0.1507
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.01 0.0555 0.0604
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0022 0.0034
Onchocerca volvulus Alhambra homolog 0.0059 0.028 0.045
Brugia malayi serine/threonine-protein kinase plk-2 0.0097 0.0532 0.0579
Schistosoma mansoni intermediate filament proteins 0.0027 0.0069 0.0067
Mycobacterium ulcerans 6-phosphofructokinase 0.0108 0.0603 0.2728
Trypanosoma brucei unspecified product 0.0091 0.049 0.1556
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0166 0.0989 0.3233
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0059 0.028 0.0279
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0019 0.0018 0.0018
Brugia malayi Pre-SET motif family protein 0.0839 0.5436 0.592
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0084 0.0134
Trypanosoma brucei DNA polymerase kappa, putative 0.0158 0.0936 0.3021
Leishmania major NADH dehydrogenase, putative 0.0044 0.0183 0.0546
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0097 0.0532 0.0585
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0044 0.0183 0.0294
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0047 0.0201 0.0246
Mycobacterium ulcerans glutamate synthase subunit beta 0.0044 0.0183 0.0135
Brugia malayi Protein kinase domain containing protein 0.1407 0.9182 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0022 0.0023
Trypanosoma brucei DNA polymerase eta, putative 0.0183 0.11 0.3564
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0084 0.022
Treponema pallidum thioredoxin reductase (trxB) 0.0044 0.0183 0.027
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0116 0.0658 0.0724
Toxoplasma gondii thioredoxin reductase 0.0479 0.3056 1
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0044 0.0183 0.0546
Loa Loa (eye worm) hypothetical protein 0.002 0.0022 0.0023
Echinococcus multilocularis phd:f box containing protein 0.0019 0.0018 0.0018
Mycobacterium leprae conserved hypothetical protein 0.0047 0.0201 0.0023
Brugia malayi hypothetical protein 0.0025 0.0059 0.0064
Trypanosoma brucei DNA polymerase kappa, putative 0.0138 0.0803 0.2585
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0022 0.0023
Entamoeba histolytica deoxycytidyl transferase, putative 0.0131 0.076 0.2021
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0059 0.0137
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0044 0.0183 0.0135
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0044 0.0183 0.0546
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0044 0.0183 0.0546
Brugia malayi hypothetical protein 0.002 0.0022 0.0024
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0131 0.076 0.0836
Plasmodium vivax DNA repair protein REV1, putative 0.0041 0.0162 0.0474
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0024 0.0023
Trypanosoma brucei DNA polymerase kappa, putative 0.0158 0.0936 0.3021
Echinococcus multilocularis geminin 0.0339 0.2131 0.2347
Leishmania major mitochondrial DNA polymerase beta 0.0305 0.1908 0.6222
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0022 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0022 0.0034
Trypanosoma cruzi DNA polymerase kappa, putative 0.0158 0.0936 0.3058
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.1093 0.711 0.8958
Leishmania major hypothetical protein, conserved 0.0025 0.0059 0.0137
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0018
Leishmania major hypothetical protein, conserved 0.0044 0.0183 0.0546
Schistosoma mansoni DNA polymerase IV / kappa 0.0041 0.0162 0.016
Trypanosoma cruzi polo-like protein kinase, putative 0.0097 0.0532 0.1736
Schistosoma mansoni disulfide oxidoreductase 0.0044 0.0183 0.0182
Brugia malayi F/Y-rich N-terminus family protein 0.0024 0.0048 0.0053
Leishmania major peptidyl-prolyl cis-trans isomerase, putative 0.003 0.0094 0.0251
Schistosoma mansoni tyrosine kinase 0.139 0.9073 0.9073
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0041 0.0162 0.0474
Trypanosoma cruzi DNA polymerase eta, putative 0.0183 0.11 0.3598
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.0362 0.0361
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0197 0.0195
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0166 0.0989 0.3196
Brugia malayi MyTH4 domain containing protein 0.0016 0.0001 0.0001
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0047 0.0201 0.1294
Mycobacterium ulcerans hypothetical protein 0.0161 0.0954 0.4903
Brugia malayi PXA domain containing protein 0.002 0.0022 0.0024
Brugia malayi protein-tyrosine-phosphatase 0.0016 0.0001 0.0001
Echinococcus granulosus lysine specific demethylase 5A 0.0071 0.0362 0.0397
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0166 0.0989 0.3196
Brugia malayi jmjC domain containing protein 0.0019 0.0018 0.0019
Echinococcus granulosus dna polymerase eta 0.0183 0.11 0.1212
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0122 0.0698 0.076
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0138 0.0803 0.0802
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.012 0.0687 0.0757
Loa Loa (eye worm) hypothetical protein 0.002 0.0022 0.0023
Onchocerca volvulus 0.012 0.0687 0.1107
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0209 0.0335
Giardia lamblia Kinase, PLK 0.0097 0.0532 0.1219
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0532 0.0855
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0166 0.0989 0.5117
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0197 0.0195
Brugia malayi phosphofructokinase 0.0108 0.0603 0.0656
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0044 0.0183 0.0546
Leishmania major trypanothione reductase 0.0479 0.3056 1
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0166 0.0989 0.1042
Plasmodium falciparum glutathione reductase 0.0166 0.0989 0.3196
Echinococcus granulosus dna polymerase kappa 0.0158 0.0936 0.103
Echinococcus granulosus histone lysine methyltransferase setb 0.012 0.0687 0.0757
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0043 0.0176 0.0521
Trypanosoma brucei unspecified product 0.0091 0.049 0.1556
Trichomonas vaginalis glutathione reductase, putative 0.0166 0.0989 0.1593
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0047 0.0205 0.0617
Giardia lamblia Glutamate synthase 0.0044 0.0183 0.027
Loa Loa (eye worm) hypothetical protein 0.0183 0.11 0.1197
Echinococcus multilocularis PHD finger protein rhinoceros 0.0059 0.028 0.0308
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0044 0.0183 0.0486
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.1215 0.7915 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0839 0.5436 0.592
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0166 0.0989 0.3196
Echinococcus multilocularis dna polymerase eta 0.0183 0.11 0.1212
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0047 0.0201 0.0605
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0044 0.0183 0.0596
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0084 0.0134
Brugia malayi 6-phosphofructokinase 0.0108 0.0603 0.0656
Echinococcus multilocularis JmjC domain containing protein 4 0.0019 0.0018 0.0018
Trypanosoma cruzi DNA polymerase kappa, putative 0.0158 0.0936 0.3058
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0098 0.0539 0.176
Entamoeba histolytica transcription factor BTF3, putative 0.0035 0.0126 0.0332
Echinococcus granulosus glutamate synthase 0.0044 0.0183 0.0201
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0166 0.0989 0.3233
Mycobacterium ulcerans hypothetical protein 0.0044 0.0183 0.0135
Giardia lamblia DINP protein human, muc B family 0.0138 0.0803 0.196
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.0603 0.1603
Brugia malayi jmjC domain containing protein 0.0071 0.0362 0.0394
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0022 0.0021
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0585 0.3753 1
Plasmodium vivax glutathione reductase, putative 0.0479 0.3056 1
Trichomonas vaginalis glutamate synthase, putative 0.0044 0.0183 0.0294
Brugia malayi hypothetical protein 0.0016 0.0001 0.0001
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.003 0.0094 0.0303
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0176 0.0572
Entamoeba histolytica hypothetical protein 0.002 0.0022 0.0056
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0192 0.1162 0.128
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0585 0.3753 0.6051
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0057 0.0267 0.0108
Brugia malayi Ferm domain 0.0016 0.0001 0.0001
Loa Loa (eye worm) PHD-finger family protein 0.0059 0.028 0.0304
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.002 0.0024 0.0026
Trypanosoma brucei DNA polymerase kappa, putative 0.0158 0.0936 0.3021
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0018 0.0018
Brugia malayi GRP1 binding protein 0.0016 0.0001 0.0001
Schistosoma mansoni glutamate synthase 0.0044 0.0183 0.0182
Echinococcus multilocularis musashi 0.0027 0.0069 0.0074
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0059 0.0137
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0108 0.0603 0.0542
Echinococcus multilocularis lamin 0.0027 0.0069 0.0074
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0022 0.0024
Mycobacterium tuberculosis Probable reductase 0.1093 0.711 0.8958
Brugia malayi jmjC domain containing protein 0.0019 0.0018 0.0019
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0044 0.0183 0.0546
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0044 0.0183 0.0201
Giardia lamblia DNA damage repair protein 0.0041 0.0162 0.0211
Schistosoma mansoni axis inhibition protein axin 0.002 0.0022 0.0021
Leishmania major phosphopantetheinyl transferase-like protein 0.0047 0.0201 0.0605
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0024 0.0023
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0044 0.0183 0.0294
Schistosoma mansoni lamin 0.0027 0.0069 0.0067
Schistosoma mansoni hypothetical protein 0.0339 0.2131 0.213
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0044 0.0183 0.0294
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0166 0.0989 0.3196
Schistosoma mansoni cellular tumor antigen P53 0.005 0.022 0.0218
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0286 0.1778 0.2063
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0162 0.0525
Toxoplasma gondii PHD-finger domain-containing protein 0.0059 0.028 0.0864
Onchocerca volvulus 0.0166 0.0991 0.1595
Trichomonas vaginalis set domain proteins, putative 0.0955 0.6202 1
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0022 0.0034
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.082 0.5306 0.5847
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.012 0.0687 0.0686
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0176 0.0572
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0585 0.3753 0.6051
Schistosoma mansoni lamin 0.0027 0.0069 0.0067
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0044 0.0183 0.02
Echinococcus multilocularis tumor protein p63 0.0339 0.2128 0.2344
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0044 0.0183 0.0546
Echinococcus multilocularis L aminoadipate semialdehyde 0.0166 0.0991 0.1091
Entamoeba histolytica thioredoxin reductase, putative 0.0044 0.0183 0.0486
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0018
Toxoplasma gondii selenide, water dikinase 0.0044 0.0183 0.0546
Brugia malayi neurofibromatosis homolog protein 1 0.0016 0.0001 0.0001
Mycobacterium tuberculosis Conserved hypothetical protein 0.0161 0.0954 0.0997
Schistosoma mansoni regulator of G protein signaling 0.002 0.0022 0.0021
Echinococcus multilocularis microtubule associated protein 2 0.138 0.9008 0.9928
Trypanosoma cruzi DNA damage repair protein, putative 0.0041 0.0162 0.0525
Echinococcus multilocularis protein tyrosine kinase 0.139 0.9073 1
Trichomonas vaginalis rotamase, putative 0.0098 0.0539 0.0867
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0084 0.0134
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0166 0.0989 0.3196
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0108 0.0603 0.1413
Plasmodium vivax basic transcription factor 3b, putative 0.0035 0.0126 0.0356
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0044 0.0183 0.0546
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0126 0.0201
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0044 0.0183 0.0546
Plasmodium falciparum basic transcription factor 3b, putative 0.0035 0.0126 0.0356
Toxoplasma gondii NAC domain-containing protein 0.0035 0.0126 0.0356
Giardia lamblia Thioredoxin reductase 0.0044 0.0183 0.027
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0025 0.0059 0.0063
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0069 0.0075
Trypanosoma brucei DNA polymerase kappa, putative 0.0158 0.0936 0.3021
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.1215 0.7915 1
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0044 0.0183 0.0201
Wolbachia endosymbiont of Brugia malayi NADPH-dependent glutamate synthase beta chain 0.0044 0.0183 0.1002
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0286 0.1778 1
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0097 0.0532 0.1692
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0047 0.0201 0.0605
Echinococcus granulosus PHD finger protein rhinoceros 0.0059 0.028 0.0308
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0585 0.3753 0.6051
Giardia lamblia PHD finger protein 15 0.0059 0.028 0.0534
Loa Loa (eye worm) thioredoxin reductase 0.0479 0.3056 0.3328
Schistosoma mansoni hypothetical protein 0.0339 0.2131 0.213
Brugia malayi PHD-finger family protein 0.0019 0.0019 0.0021
Echinococcus granulosus peregrin 0.0059 0.028 0.0308
Echinococcus granulosus protein tyrosine kinase 0.139 0.9073 1
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.0603 0.097
Giardia lamblia Fructose-bisphosphate aldolase 0.0585 0.3753 1
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0084 0.022
Echinococcus granulosus lamin dm0 0.0027 0.0069 0.0074
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.002 0.0022 0.0023
Brugia malayi beta-NAC-like protein 0.0035 0.0126 0.0137
Echinococcus granulosus Regulator of G protein signaling 20 0.002 0.0022 0.0023
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0044 0.0183 0.0201
Trypanosoma cruzi trypanothione reductase, putative 0.0166 0.0989 0.3233
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0022 0.0024
Schistosoma mansoni phd/f-box containing protein 0.0019 0.0018 0.0016
Schistosoma mansoni hypothetical protein 0.0044 0.0183 0.0182
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0166 0.0989 1
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0098 0.0539 0.176
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0183 0.0596
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0197 0.0215
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0043 0.0176 0.0572
Brugia malayi A-kinase anchor protein 10, precursor 0.002 0.0022 0.0024
Mycobacterium ulcerans DNA polymerase IV 0.0158 0.0936 0.4787
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.002 0.0024 0.0025
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0069 0.0073
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0131 0.076 0.0758
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0305 0.1908 0.6243
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0044 0.0183 0.0294
Echinococcus granulosus expressed protein 0.0383 0.2418 0.2664
Echinococcus granulosus geminin 0.0339 0.2131 0.2347
Loa Loa (eye worm) 6-phosphofructokinase 0.0108 0.0603 0.0655
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0166 0.0989 0.1077
Plasmodium vivax hypothetical protein, conserved 0.0019 0.0019 0.0005
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0166 0.0989 0.5117
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0047 0.0201 0.0246
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0069 0.0073
Brugia malayi FERM domain 0.0016 0.0001 0.0001
Trypanosoma brucei DNA polymerase IV, putative 0.0158 0.0936 0.3021
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0166 0.0989 0.3233
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0022 0.0023
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0532 0.0855
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.002 0.0022 0.0023
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0044 0.0183 0.02
Echinococcus granulosus microtubule associated protein 2 0.138 0.9008 0.9928
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0044 0.0183 0.1002
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0197 0.0215
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.002 0.0024 0.0025
Loa Loa (eye worm) jmjC domain-containing protein 0.0121 0.0693 0.0754
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0057 0.0267 0.0654
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0019 0.0018 0.0016
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0018 0.0018
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0022 0.0023
Loa Loa (eye worm) MH2 domain-containing protein 0.0239 0.1469 0.1599
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0057 0.0267 0.0293
Echinococcus granulosus intermediate filament protein 0.0027 0.0069 0.0074
Brugia malayi AF-10 protein 0.0019 0.0019 0.0021
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0108 0.0603 0.0542
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.0603 0.097
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.012 0.0687 0.0686
Echinococcus granulosus 6 phosphofructokinase 0.0108 0.0603 0.0663
Toxoplasma gondii PHD-finger domain-containing protein 0.0019 0.0019 0.0005
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0197 0.0215
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.0126 0.0408
Echinococcus granulosus Solute carrier family 22 5 0.1024 0.6656 0.7336
Echinococcus granulosus lamin 0.0027 0.0069 0.0074
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0044 0.0183 0.0294
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0044 0.0183 0.0546
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0044 0.0183 0.0201
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0166 0.0989 0.3233
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.012 0.0687 0.0686
Echinococcus multilocularis 6 phosphofructokinase 0.0108 0.0603 0.0663
Trypanosoma brucei hypothetical protein, conserved 0.0041 0.0162 0.0474
Onchocerca volvulus 0.0027 0.0069 0.0109
Schistosoma mansoni regulator of G protein signaling 0.002 0.0022 0.0021
Chlamydia trachomatis thioredoxin reductase 0.0044 0.0183 0.1096
Mycobacterium ulcerans monoxygenase 0.0044 0.0183 0.0135
Loa Loa (eye worm) transcription factor SMAD2 0.0239 0.1469 0.1599
Trypanosoma brucei DNA polymerase kappa, putative 0.0158 0.0936 0.3021
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.003 0.0094 0.0251
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0532 0.0855
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0097 0.0532 0.0578
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0044 0.0183 0.0596
Echinococcus multilocularis expressed protein 0.01 0.0555 0.061
Trypanosoma brucei DNA polymerase kappa, putative 0.0097 0.0534 0.17
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0019 0.0019 0.0005
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0166 0.0989 0.3233
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0122 0.0698 0.076
Onchocerca volvulus 0.0956 0.6203 1
Onchocerca volvulus 0.0044 0.0183 0.0294
Toxoplasma gondii PPIC-type PPIASE domain-containing protein 0.003 0.0094 0.0251
Trypanosoma brucei DNA damage repair protein, putative 0.0041 0.0162 0.0474
Schistosoma mansoni 6-phosphofructokinase 0.0108 0.0603 0.0601
Brugia malayi regulator of G-protein signaling egl-10 0.002 0.0022 0.0024
Schistosoma mansoni regulator of G protein signaling 0.002 0.0022 0.0021
Loa Loa (eye worm) hypothetical protein 0.012 0.0687 0.0748
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0019 0.0019 0.0005
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0044 0.0183 0.0135
Schistosoma mansoni transcription factor btf3 0.0035 0.0126 0.0125
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0084 0.022
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0084 0.0134
Trypanosoma brucei DNA polymerase kappa, putative 0.0097 0.0534 0.17
Brugia malayi Thioredoxin reductase 0.0479 0.3056 0.3329
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0166 0.0989 0.3196
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0022 0.0023
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0044 0.0183 0.0486
Leishmania major DNA polymerase kappa, putative 0.0041 0.0162 0.0474
Brugia malayi PHD-finger family protein 0.0059 0.028 0.0305
Toxoplasma gondii hypothetical protein 0.0049 0.0218 0.0658
Trypanosoma brucei DNA polymerase kappa, putative 0.0158 0.0936 0.3021
Onchocerca volvulus 0.0027 0.0069 0.0109
Brugia malayi jmjC domain containing protein 0.0019 0.0018 0.0019
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0059 0.019
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0084 0.022
Plasmodium falciparum ferrodoxin reductase-like protein 0.0044 0.0183 0.0546
Brugia malayi Ferm domain 0.0016 0.0001 0.0001
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0197 0.0195
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0108 0.0603 0.1925
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0166 0.0989 0.3196
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0057 0.0267 0.0291
Toxoplasma gondii NADPH-glutathione reductase 0.0166 0.0989 0.3196
Loa Loa (eye worm) jmjC domain-containing protein 0.0071 0.0362 0.0393
Mycobacterium ulcerans DNA polymerase IV 0.0158 0.0936 0.4787
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0059 0.0137
Onchocerca volvulus Serine\/threonine kinase homolog 0.0097 0.0532 0.0855
Echinococcus granulosus jumonji domain containing protein 0.0082 0.0432 0.0475
Trypanosoma brucei DNA polymerase IV, putative 0.0158 0.0936 0.3021
Echinococcus multilocularis lamin dm0 0.0027 0.0069 0.0074
Echinococcus multilocularis jumonji domain containing 1A 0.0019 0.0018 0.0018
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.0603 0.1603
Trypanosoma brucei trypanothione reductase 0.0479 0.3056 1
Echinococcus multilocularis lysine specific demethylase 6a 0.0019 0.0018 0.0018
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0138 0.0803 0.2585
Trichomonas vaginalis conserved hypothetical protein 0.01 0.0555 0.0892
Echinococcus multilocularis dna polymerase kappa 0.0158 0.0936 0.103
Brugia malayi regulator of G-protein signaling rgs-7 0.002 0.0022 0.0024
Trichomonas vaginalis mercuric reductase, putative 0.0166 0.0989 0.1593
Loa Loa (eye worm) phosphofructokinase 0.0108 0.0603 0.0655
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0044 0.0183 0.0546
Brugia malayi hypothetical protein 0.0016 0.0001 0.0001
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0044 0.0183 0.0198
Trichomonas vaginalis rotamase, putative 0.01 0.0555 0.0892
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0019 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.002 0.0022 0.0023
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0166 0.0989 0.3233
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.0603 0.097
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0044 0.0183 0.0201
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0166 0.0989 0.3233
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0044 0.0183 0.0135
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0044 0.0183 0.0201
Schistosoma mansoni jumonji domain containing protein 0.0019 0.0018 0.0016
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0019 0.0018 0.0053
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0131 0.076 0.0826
Trypanosoma cruzi DNA damage repair protein, putative 0.0041 0.0162 0.0525
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0024 0.0023
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0057 0.0267 0.0654
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0144 0.0847 0.2728
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0585 0.3753 1
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0044 0.0183 0.0546
Brugia malayi GH28553p 0.0016 0.0001 0.0001
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0197 0.0215
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0044 0.0183 0.0546
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0044 0.0183 0.0135
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0044 0.0183 0.0294
Brugia malayi Talin 1 0.0016 0.0001 0.0001
Plasmodium vivax ferrodoxin reductase, putative 0.0044 0.0183 0.0546
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0166 0.0989 0.3233
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0044 0.0183 0.0486
Echinococcus multilocularis glutamate synthase 0.0044 0.0183 0.0201
Brugia malayi 6-phosphofructokinase 0.0108 0.0603 0.0656
Trypanosoma brucei DNA polymerase kappa, putative 0.0097 0.0534 0.17
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0019 0.0019 0.0005
Entamoeba histolytica hypothetical protein 0.0047 0.0201 0.0533
Mycobacterium ulcerans NADH dehydrogenase 0.0044 0.0183 0.0135
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0585 0.3753 0.6051
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.003 0.0094 0.0303
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0131 0.076 0.0836
Schistosoma mansoni terminal deoxycytidyl transferase 0.0131 0.076 0.0758
Schistosoma mansoni 6-phosphofructokinase 0.0108 0.0603 0.0601
Entamoeba histolytica hypothetical protein 0.002 0.0022 0.0056
Brugia malayi glutamate synthase 0.0044 0.0183 0.02
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0022 0.0021
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.012 0.0687 0.0757
Entamoeba histolytica hypothetical protein 0.002 0.0022 0.0056
Trichomonas vaginalis glutamate synthase, putative 0.0044 0.0183 0.0294
Loa Loa (eye worm) hypothetical protein 0.0044 0.0183 0.0198
Trypanosoma brucei DNA polymerase kappa, putative 0.0067 0.0337 0.1053
Echinococcus granulosus L aminoadipate semialdehyde 0.0166 0.0991 0.1091
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.0362 0.0361
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0044 0.0183 0.0201
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.0603 0.097
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0044 0.0183 0.0201
Leishmania major DNA polymerase kappa, putative 0.0138 0.0803 0.2585
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0532 0.0855
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0044 0.0183 0.0486
Echinococcus granulosus transcription factor btf3 0.0035 0.0126 0.0137
Loa Loa (eye worm) 6-phosphofructokinase 0.0108 0.0603 0.0655
Echinococcus granulosus JmjC domain containing protein 4 0.0019 0.0018 0.0018
Mycobacterium ulcerans ferredoxin reductase 0.0044 0.0183 0.0135
Trypanosoma brucei hypothetical protein, conserved 0.0041 0.0162 0.0474
Schistosoma mansoni serine/threonine protein kinase 0.0097 0.0532 0.053
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0183 0.0596
Schistosoma mansoni sulfide quinone reductase 0.0044 0.0183 0.0182
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0084 0.022
Loa Loa (eye worm) hypothetical protein 0.0026 0.0065 0.007
Trichomonas vaginalis apoptosis inducing factor, putative 0.0044 0.0183 0.0294
Schistosoma mansoni axis inhibition protein axin 0.002 0.0022 0.0021
Schistosoma mansoni kinase 0.0049 0.0217 0.0216
Loa Loa (eye worm) programmed cell death 8 0.0044 0.0183 0.0198
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0044 0.0183 0.0201
Trypanosoma brucei hypothetical protein, conserved 0.0047 0.0201 0.0605
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0166 0.0991 0.099
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0084 0.022
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0532 0.0855
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0053 0.0242 0.0262
Loa Loa (eye worm) hypothetical protein 0.005 0.022 0.0238
Entamoeba histolytica serine/threonine protein kinase, putative 0.0097 0.0532 0.1414
Schistosoma mansoni z-protein (S1r protein) 0.002 0.0022 0.0021
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0197 0.0214
Entamoeba histolytica hypothetical protein 0.0035 0.0126 0.0332
Plasmodium vivax thioredoxin reductase, putative 0.0479 0.3056 1
Leishmania major DNA polymerase eta, putative 0.0183 0.11 0.3564
Plasmodium falciparum phd finger protein, putative 0.0059 0.028 0.0864
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0084 0.022
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0166 0.0991 0.1079
Schistosoma mansoni sulfide quinone reductase 0.0044 0.0183 0.0182
Echinococcus multilocularis expressed protein 0.0383 0.2418 0.2664
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0585 0.3753 0.6051
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0166 0.0989 0.3196
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0166 0.0989 0.3196
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0022 0.0034
Treponema pallidum fructose-bisphosphate aldolase 0.0585 0.3753 1
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0532 0.0855
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0166 0.0989 0.1089
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0044 0.0183 0.0294
Brugia malayi MH2 domain containing protein 0.0239 0.1469 0.16
Echinococcus granulosus expressed protein 0.01 0.0555 0.061
Schistosoma mansoni hypothetical protein 0.0059 0.028 0.0279
Brugia malayi Ferm domain (protein4.1-ezrin-radixin-moesin) family protein 4-like 0.0016 0.0001 0.0001
Echinococcus multilocularis lysine specific demethylase 5A 0.0071 0.0362 0.0397
Echinococcus granulosus phd:f box containing protein 0.0019 0.0018 0.0018
Trichomonas vaginalis DNA polymerase eta, putative 0.0158 0.0936 0.1507
Trypanosoma brucei chrX additional, unordered contigs 0.0041 0.0162 0.0474
Echinococcus multilocularis transcription factor btf3 0.0035 0.0126 0.0137
Trypanosoma cruzi trypanothione reductase, putative 0.0479 0.3056 1
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0047 0.0201 0.0605
Trypanosoma brucei DNA polymerase kappa, putative 0.0158 0.0936 0.3021
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0022 0.0023
Schistosoma mansoni jumonji domain containing protein 0.0153 0.0901 0.09
Trypanosoma brucei DNA polymerase kappa, putative 0.0067 0.0337 0.1053
Echinococcus granulosus tumor protein p63 0.0339 0.2128 0.2344
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.0126 0.0408
Schistosoma mansoni glutamate synthase 0.0044 0.0183 0.0182
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0532 0.0855
Loa Loa (eye worm) hypothetical protein 0.0059 0.028 0.0304
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0585 0.3753 0.6051
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0286 0.1778 0.2063
Trypanosoma brucei DNA damage repair protein, putative 0.0041 0.0162 0.0474
Trypanosoma cruzi DNA polymerase kappa, putative 0.0158 0.0936 0.3058
Loa Loa (eye worm) hypothetical protein 0.002 0.0022 0.0023
Leishmania major DNA damage repair protein, putative 0.0041 0.0162 0.0474
Brugia malayi ImpB/MucB/SamB family protein 0.0183 0.11 0.1199
Trypanosoma cruzi DNA polymerase eta, putative 0.0092 0.0502 0.1641
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0144 0.0847 0.2728
Brugia malayi intermediate filament protein 0.0027 0.0069 0.0075
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.012 0.0687 0.2205
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0144 0.0847 0.2767
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0044 0.0183 0.0596
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0073 0.0374 0.041
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0047 0.0201 0.0319
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0044 0.0183 0.0135
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0044 0.0183 0.0596
Echinococcus multilocularis thioredoxin glutathione reductase 0.0482 0.3073 0.3387
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0047 0.0201 0.0023
Echinococcus granulosus axis inhibition protein axin 0.002 0.0022 0.0023
Loa Loa (eye worm) hypothetical protein 0.0019 0.0019 0.002
Leishmania major DNA polymerase eta, putative 0.0092 0.0502 0.1596
Mycobacterium tuberculosis Probable dehydrogenase 0.1093 0.711 0.8958
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0019 0.0019 0.0005
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.002 0.0022 0.0034
Brugia malayi PXA domain containing protein 0.002 0.0022 0.0024
Schistosoma mansoni phosphatidylserine receptor 0.0019 0.0018 0.0016
Leishmania major ATP-dependent phosphofructokinase 0.0108 0.0603 0.1925
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0166 0.0989 0.5117
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0108 0.0603 0.1968
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0126 0.0201
Brugia malayi jmjC domain containing protein 0.0019 0.0018 0.0019
Trypanosoma cruzi DNA polymerase kappa, putative 0.0158 0.0936 0.3058
Echinococcus granulosus axis inhibition protein axin 0.002 0.0022 0.0023
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0162 0.0525
Trypanosoma brucei unspecified product 0.0151 0.0892 0.2877
Plasmodium vivax hypothetical protein, conserved 0.0059 0.028 0.0864
Echinococcus multilocularis Regulator of G protein signaling 20 0.002 0.0022 0.0023
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0044 0.0183 0.0135
Plasmodium falciparum DNA repair protein REV1, putative 0.0041 0.0162 0.0474
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0044 0.0183 0.0596
Trypanosoma brucei DNA polymerase kappa, putative 0.0158 0.0936 0.3021
Entamoeba histolytica disulphide oxidoreductase, putative 0.0044 0.0183 0.0486
Echinococcus granulosus lysine specific demethylase 6a 0.0019 0.0018 0.0018
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.1215 0.7915 1
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0022 0.0034
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0209 0.0335
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0098 0.0539 0.1433
Leishmania major hypothetical protein, conserved 0.0044 0.0183 0.0546
Trypanosoma cruzi NADH dehydrogenase, putative 0.0044 0.0183 0.0596
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0059 0.019
Mycobacterium ulcerans dehydrogenase 0.0044 0.0183 0.0135

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 4 Concentration required for 50% inhibition of the adenosine kinase (AK) activity. ChEMBL. 15149648

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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