Detailed information for compound 159172

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 523.41 | Formula: C21H24N4O10P-
  • H donors: 4 H acceptors: 6 LogP: -1.96 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 2
  • SMILES: COC(=O)[C@H](OP(=O)(OCC1OC(C(C1O)O)n1ccc(nc1=O)N)[O-])Cc1c[nH]c2c1cccc2
  • InChi: 1S/C21H25N4O10P/c1-32-20(28)14(8-11-9-23-13-5-3-2-4-12(11)13)35-36(30,31)33-10-15-17(26)18(27)19(34-15)25-7-6-16(22)24-21(25)29/h2-7,9,14-15,17-19,23,26-27H,8,10H2,1H3,(H,30,31)(H2,22,24,29)/p-1/t14-,15?,17?,18?,19?/m0/s1
  • InChiKey: TWFYMPWIXONGKD-HKYYBYOSSA-M  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0047 0.0145 0.0388
Plasmodium falciparum serine repeat antigen 8 0.0159 0.0719 0.1925
Onchocerca volvulus 0.0307 0.1481 0.3943
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0047 0.0145 0.0388
Schistosoma mansoni cathepsin C 0.0159 0.0719 0.0726
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.0022 0.0014 0.0019
Giardia lamblia Cysteine protease 0.0159 0.0719 0.345
Plasmodium falciparum thioredoxin reductase 0.0047 0.0145 0.0388
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0313 0.1512 0.1512
Brugia malayi ImpB/MucB/SamB family protein 0.0102 0.0428 0.0589
Trichomonas vaginalis DNA polymerase eta, putative 0.0104 0.0434 0.111
Leishmania major T-complex protein 1, beta subunit, putative 0.0024 0.0023 0.0061
Plasmodium falciparum glutathione reductase 0.0047 0.0145 0.0388
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0159 0.0719 0.099
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0237 0.1122 0.1546
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0047 0.0145 0.0977
Trichomonas vaginalis conserved hypothetical protein 0.0159 0.0719 0.1838
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0022 0.0014 0.0014
Echinococcus multilocularis dna polymerase eta 0.0102 0.0428 0.0432
Trypanosoma brucei DNA polymerase kappa, putative 0.0104 0.0434 0.1162
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0159 0.0719 0.0726
Echinococcus multilocularis thioredoxin glutathione reductase 0.0138 0.0609 0.0616
Plasmodium vivax unspecified product 0.0237 0.1122 0.3006
Trypanosoma brucei DNA polymerase kappa, putative 0.0052 0.0167 0.0446
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0159 0.0719 0.1838
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0744 0.3734 0.9551
Echinococcus granulosus histone acetyltransferase KAT2B 0.0041 0.0114 0.0115
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0022 0.0014 0.0014
Plasmodium falciparum thioredoxin reductase 0.0137 0.0607 0.1624
Plasmodium falciparum cysteine proteinase falcipain 1 0.0396 0.1941 0.5198
Plasmodium vivax vivapain-3 0.0396 0.1941 0.5198
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0022 0.0014 0.0014
Trichomonas vaginalis bromodomain-containing protein, putative 0.0041 0.0114 0.029
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0047 0.0145 0.0282
Brugia malayi hypothetical protein 0.0052 0.0166 0.0229
Entamoeba histolytica cysteine proteinase, putative 0.0507 0.2512 0.6726
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0047 0.0145 0.0282
Loa Loa (eye worm) hypothetical protein 0.0159 0.0719 0.099
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.1014 0.5131 0.5185
Trypanosoma brucei importin beta-1 subunit, putative 0.0057 0.0192 0.0514
Schistosoma mansoni sodium/solute symporter 0.0037 0.0092 0.0093
Trichomonas vaginalis mercuric reductase, putative 0.0047 0.0145 0.037
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.019 0.051
Brugia malayi CXXC zinc finger family protein 0.0028 0.0044 0.006
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0159 0.0719 0.1925
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0024 0.0023 0.0061
Giardia lamblia Cathepsin B precursor 0.0423 0.2083 1
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0024 0.0023 0.0023
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0348 0.1692 0.1692
Trypanosoma brucei DNA damage repair protein, putative 0.0023 0.002 0.0054
Schistosoma mansoni Smad4 0.0024 0.0026 0.0026
Trypanosoma cruzi DNA polymerase kappa, putative 0.0104 0.0434 0.0846
Echinococcus granulosus short transient receptor potential channel 6 0.0062 0.0221 0.0223
Entamoeba histolytica cysteine protease, putative 0.0159 0.0719 0.1925
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0022 0.0014 0.0014
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0307 0.1481 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0047 0.0145 0.0388
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0042 0.0115 0.0308
Trypanosoma brucei importin beta-1 subunit, putative 0.0057 0.0192 0.0514
Entamoeba histolytica cysteine proteinase, putative 0.0396 0.1941 0.5198
Trichomonas vaginalis importin beta-1, putative 0.0046 0.0137 0.035
Trichomonas vaginalis glucosylceramidase, putative 0.051 0.2531 0.6473
Mycobacterium tuberculosis Conserved protein 0.0307 0.1481 0.1481
Echinococcus granulosus cathepsin L 0.0396 0.1941 0.1962
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0042 0.0115 0.0308
Giardia lamblia Cathepsin L-like protease 0.0159 0.0719 0.345
Trypanosoma brucei trypanothione reductase 0.0137 0.0607 0.1624
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0022 0.0014 0.0014
Echinococcus granulosus TRP transient receptor potential channel 0.0035 0.008 0.0081
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0744 0.3734 1
Plasmodium falciparum serine repeat antigen 4 0.0159 0.0719 0.1925
Schistosoma mansoni inositol transporter 0.0037 0.0092 0.0093
Brugia malayi Cathepsin L-like precursor 0.0744 0.3734 0.5143
Trichomonas vaginalis glucosylceramidase, putative 0.0778 0.391 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0744 0.3734 0.9551
Loa Loa (eye worm) hypothetical protein 0.0237 0.1122 0.1546
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0047 0.0145 0.0282
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.002 0.0054
Brugia malayi Papain family cysteine protease containing protein 0.0159 0.0719 0.099
Trichomonas vaginalis GTP-binding protein (z) alpha subunit, gnaz, putative 0.0022 0.0014 0.0036
Echinococcus granulosus muscleblind protein 0.0149 0.0669 0.0676
Echinococcus granulosus geminin 0.1938 0.9895 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0744 0.3734 0.9551
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0037 0.0092 0.0246
Brugia malayi Cathepsin L-like cysteine proteinase 0.0507 0.2512 0.346
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0022 0.0014 0.0036
Loa Loa (eye worm) hypothetical protein 0.0404 0.1985 0.2734
Trypanosoma cruzi DNA polymerase kappa, putative 0.0104 0.0434 0.0846
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.0022 0.0014 0.0019
Onchocerca volvulus 0.0744 0.3734 1
Mycobacterium ulcerans esterase/lipase LipP 0.0307 0.1481 1
Onchocerca volvulus 0.0159 0.0719 0.1894
Schistosoma mansoni DNA polymerase eta 0.0102 0.0428 0.0432
Echinococcus multilocularis short transient receptor potential channel 6 0.0062 0.0221 0.0223
Schistosoma mansoni eyes absent homolog 0.0095 0.0388 0.0392
Leishmania major cathepsin L-like protease 0.0744 0.3734 1
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0159 0.0719 0.345
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0022 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0507 0.2512 0.346
Loa Loa (eye worm) MH1 domain-containing protein 0.0024 0.0026 0.0036
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0047 0.0145 0.0282
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0047 0.0145 0.0146
Schistosoma mansoni glutaminase 0.0279 0.1337 0.1351
Trypanosoma cruzi DNA polymerase eta, putative 0.0102 0.0428 0.0834
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0137 0.0607 0.0607
Echinococcus multilocularis dna polymerase kappa 0.0104 0.0434 0.0438
Brugia malayi MH1 domain containing protein 0.0024 0.0026 0.0036
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0744 0.3734 1
Schistosoma mansoni cpg binding protein 0.003 0.0052 0.0053
Plasmodium falciparum serine repeat antigen 5 0.0159 0.0719 0.1925
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0396 0.1941 0.1962
Loa Loa (eye worm) hypothetical protein 0.0307 0.1481 0.204
Loa Loa (eye worm) hypothetical protein 0.0022 0.0014 0.0019
Echinococcus granulosus dna polymerase kappa 0.0104 0.0434 0.0438
Plasmodium vivax serine-repeat antigen (SERA) 0.0159 0.0719 0.1925
Giardia lamblia Hypothetical protein 0.0159 0.0719 0.345
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0075 0.0287 0.029
Loa Loa (eye worm) latrophilin receptor protein 2 0.0404 0.1985 0.2734
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0507 0.2512 0.6424
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0203 0.0545
Loa Loa (eye worm) hypothetical protein 0.0507 0.2512 0.346
Toxoplasma gondii cathepsin B 0.0423 0.2083 0.5579
Loa Loa (eye worm) hypothetical protein 0.0159 0.0719 0.099
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0554 0.2756 0.2785
Entamoeba histolytica cysteine protease, putative 0.0396 0.1941 0.5198
Schistosoma mansoni hypothetical protein 0.0111 0.047 0.0475
Trypanosoma cruzi DNA damage repair protein, putative 0.0023 0.002 0.0039
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0515 0.2557 0.2584
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0024 0.0026 0.0026
Echinococcus granulosus cathepsin L 0.0159 0.0719 0.0726
Entamoeba histolytica hypothetical protein 0.0111 0.047 0.1258
Loa Loa (eye worm) Smad1 0.0024 0.0026 0.0036
Loa Loa (eye worm) glutathione reductase 0.0137 0.0607 0.0836
Entamoeba histolytica cysteine protease, putative 0.0396 0.1941 0.5198
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0159 0.0719 0.1838
Brugia malayi hypothetical protein 0.0022 0.0014 0.0019
Entamoeba histolytica hypothetical protein 0.0159 0.0719 0.1925
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0778 0.391 0.5385
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0042 0.0115 0.0224
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0023 0.002 0.0054
Plasmodium vivax vivapain-2 0.0744 0.3734 1
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0047 0.0145 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0744 0.3734 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0138 0.0609 0.0616
Onchocerca volvulus Cathepsin F homolog 0.0744 0.3734 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1014 0.5131 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0313 0.1512 0.1512
Trypanosoma cruzi hypothetical protein, conserved 0.0307 0.1481 0.2886
Echinococcus granulosus snurportin 1 0.0605 0.302 0.3052
Echinococcus multilocularis Smad4 0.0024 0.0026 0.0026
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0047 0.0145 0.0282
Entamoeba histolytica cysteine protease, putative 0.0744 0.3734 1
Toxoplasma gondii preprocathepsin c precursor, putative 0.0159 0.0719 0.1925
Plasmodium falciparum importin beta, putative 0.0057 0.0192 0.0514
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0159 0.0719 0.099
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0047 0.0145 0.0388
Entamoeba histolytica cysteine protease, putative 0.0159 0.0719 0.1925
Giardia lamblia Cathepsin L precursor 0.0159 0.0719 0.345
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0515 0.2557 0.3522
Schistosoma mansoni transient receptor potential channel 0.0062 0.0221 0.0223
Giardia lamblia Cathepsin L precursor 0.0159 0.0719 0.345
Trypanosoma cruzi major cysteine proteinase, putative 0.0159 0.0719 0.1401
Echinococcus granulosus TGF beta signal transducer SmadC 0.0024 0.0026 0.0026
Brugia malayi MH2 domain containing protein 0.0024 0.0026 0.0036
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0019 0.002
Entamoeba histolytica hypothetical protein 0.0046 0.0137 0.0366
Loa Loa (eye worm) acetyltransferase 0.0141 0.0626 0.0863
Leishmania major cathepsin L-like protease 0.0744 0.3734 1
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0022 0.0014 0.0014
Echinococcus multilocularis transient receptor potential ion channel A 0.0091 0.0369 0.0373
Brugia malayi hypothetical protein 0.0095 0.0388 0.0534
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0047 0.0145 0.0388
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0159 0.0719 0.1838
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0166 0.0446
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0159 0.0719 0.1925
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0042 0.0115 0.0308
Brugia malayi Cathepsin L-like precursor 0.0507 0.2512 0.346
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0159 0.0719 0.345
Trichomonas vaginalis glutathione reductase, putative 0.0047 0.0145 0.037
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0159 0.0719 0.0726
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0159 0.0719 0.1838
Echinococcus multilocularis short transient receptor potential channel 6 0.0062 0.0221 0.0223
Trypanosoma cruzi DNA polymerase kappa, putative 0.0104 0.0434 0.0846
Leishmania major hypothetical protein, conserved 0.0307 0.1481 0.3966
Onchocerca volvulus 0.0037 0.0092 0.021
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.0022 0.0014 0.0019
Leishmania major cathepsin L-like protease 0.0744 0.3734 1
Trichomonas vaginalis D-aminoacylase, putative 0.0307 0.1481 0.3788
Loa Loa (eye worm) hypothetical protein 0.0307 0.1481 0.204
Plasmodium falciparum serine repeat antigen 9 0.0159 0.0719 0.1925
Leishmania major hypothetical protein, conserved 0.0052 0.0166 0.0446
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.0022 0.0014 0.0019
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0024 0.0023 0.0023
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0022 0.0014 0.0014
Echinococcus multilocularis cysteine protease 0.0744 0.3734 0.3773
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0041 0.0114 0.029
Echinococcus granulosus Smad4 0.0024 0.0026 0.0026
Giardia lamblia Hypothetical protein 0.0159 0.0719 0.345
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0307 0.1481 0.1496
Echinococcus granulosus histone acetyltransferase KAT2B 0.0137 0.0606 0.0612
Brugia malayi cathepsin Z-like cysteine proteinase 0.0159 0.0719 0.099
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0022 0.0014 0.0014
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0396 0.1941 0.1962
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0035 0.008 0.011
Brugia malayi Smad1 0.0024 0.0026 0.0036
Brugia malayi beta-lactamase family protein 0.0307 0.1481 0.204
Brugia malayi Cathepsin L-like precursor 0.0237 0.1122 0.1546
Echinococcus granulosus cpg binding protein 0.003 0.0052 0.0053
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0022 0.0014 0.0014
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0307 0.1481 0.204
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0159 0.0719 0.1925
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0022 0.0014 0.0014
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0744 0.3734 1
Plasmodium vivax ataxin-2 like protein, putative 0.0052 0.0166 0.0446
Trypanosoma brucei DNA polymerase kappa, putative 0.0104 0.0434 0.1162
Trichomonas vaginalis conserved hypothetical protein 0.0159 0.0719 0.1838
Loa Loa (eye worm) glutaminase 2 0.0279 0.1337 0.1841
Schistosoma mansoni transient receptor potential channel 4 0.0094 0.0385 0.0389
Loa Loa (eye worm) hypothetical protein 0.0744 0.3734 0.5143
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0022 0.0014 0.0014
Trypanosoma brucei DNA polymerase kappa, putative 0.0052 0.0167 0.0446
Giardia lamblia Cathepsin B precursor 0.0159 0.0719 0.345
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0396 0.1941 0.4965
Echinococcus multilocularis importin subunit beta 1 0.0057 0.0192 0.0194
Loa Loa (eye worm) hypothetical protein 0.0307 0.1481 0.204
Mycobacterium tuberculosis Probable lipase LipD 0.0307 0.1481 0.1481
Brugia malayi MH2 domain containing protein 0.0024 0.0026 0.0036
Echinococcus granulosus cathepsin l cysteine peptidase 0.0744 0.3734 0.3773
Plasmodium vivax vivapain-1 0.0396 0.1941 0.5198
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0307 0.1481 0.1481
Plasmodium vivax DNA repair protein REV1, putative 0.0023 0.002 0.0054
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0042 0.0115 0.0224
Toxoplasma gondii cathepsin CPL 0.0744 0.3734 1
Schistosoma mansoni cpg binding protein 0.0028 0.0044 0.0044
Onchocerca volvulus Cathepsin L homolog 0.0744 0.3734 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0744 0.3734 0.9551
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0744 0.3734 0.9551
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0744 0.3734 1
Plasmodium vivax vivapain-2 0.0744 0.3734 1
Onchocerca volvulus 0.0507 0.2512 0.6714
Trichomonas vaginalis esterase, putative 0.0307 0.1481 0.3788
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0047 0.0145 0.0977
Brugia malayi Papain family cysteine protease containing protein 0.0396 0.1941 0.2674
Entamoeba histolytica cysteine protease, putative 0.0396 0.1941 0.5198
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0035 0.008 0.011
Brugia malayi cathepsin Z-like cysteine proteinase 0.0159 0.0719 0.099
Trypanosoma cruzi cysteine proteinase, putative 0.0396 0.1941 0.3783
Loa Loa (eye worm) cytochrome P450 family protein 0.0031 0.0058 0.0079
Echinococcus granulosus tumor protein p63 0.0664 0.3325 0.336
Schistosoma mansoni smad1 5 8 and 0.0024 0.0026 0.0026
Trichomonas vaginalis glucosylceramidase, putative 0.0538 0.2672 0.6836
Brugia malayi beta-lactamase 0.0307 0.1481 0.204
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0159 0.0719 0.1838
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0024 0.0023 0.0061
Brugia malayi acetyltransferase, GNAT family protein 0.0141 0.0626 0.0863
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0744 0.3734 1
Echinococcus granulosus transient receptor potential ion channel A 0.0091 0.0369 0.0373
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0047 0.0145 0.0388
Mycobacterium ulcerans DNA polymerase IV 0.0104 0.0434 0.293
Echinococcus granulosus cathepsin b 0.1014 0.5131 0.5185
Leishmania major cysteine peptidase A (CPA) 0.0744 0.3734 1
Schistosoma mansoni transient receptor potential channel 0.0094 0.0385 0.0389
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0159 0.0719 0.1838
Schistosoma mansoni hypothetical protein 0.1938 0.9895 1
Brugia malayi beta-lactamase family protein 0.0307 0.1481 0.204
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0047 0.0145 0.0146
Entamoeba histolytica cysteine protease, putative 0.0396 0.1941 0.5198
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0047 0.0145 0.0145
Echinococcus multilocularis geminin 0.1938 0.9895 1
Loa Loa (eye worm) cathepsin B 0.0423 0.2083 0.287
Plasmodium falciparum serine repeat antigen 6 0.0159 0.0719 0.1925
Brugia malayi hypothetical protein 0.0033 0.0072 0.0099
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0024 0.0023 0.0023
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0096 0.0459
Loa Loa (eye worm) hypothetical protein 0.0338 0.1642 0.2262
Trypanosoma brucei unspecified product 0.0052 0.0167 0.0447
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0313 0.1512 0.1512
Trichomonas vaginalis glucosylceramidase, putative 0.051 0.2531 0.6473
Schistosoma mansoni inositol transporter 0.0037 0.0092 0.0093
Trypanosoma cruzi DNA polymerase kappa, putative 0.0104 0.0434 0.0846
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0159 0.0719 0.0726
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0515 0.2557 0.2584
Schistosoma mansoni hypothetical protein 0.0023 0.0019 0.002
Echinococcus multilocularis beta LACTamase domain containing family member 0.0307 0.1481 0.1496
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0159 0.0719 0.1838
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1014 0.5131 0.5185
Echinococcus granulosus sodium:glucose cotransporter 0.0037 0.0092 0.0093
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0044 0.006
Trichomonas vaginalis glucosylceramidase, putative 0.051 0.2531 0.6473
Giardia lamblia NADH oxidase lateral transfer candidate 0.0047 0.0145 0.0695
Brugia malayi Transient-receptor-potential like protein 0.0035 0.008 0.0111
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0605 0.302 0.416
Loa Loa (eye worm) hypothetical protein 0.0094 0.0385 0.053
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0145 0.0282
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0024 0.0023 0.0023
Mycobacterium ulcerans DNA polymerase IV 0.0104 0.0434 0.293
Giardia lamblia Cathepsin L precursor 0.0159 0.0719 0.345
Trichomonas vaginalis glucosylceramidase, putative 0.0778 0.391 1
Entamoeba histolytica cysteine protease, putative 0.0396 0.1941 0.5198
Schistosoma mansoni importin beta-1 0.0057 0.0192 0.0194
Loa Loa (eye worm) hypothetical protein 0.0873 0.4404 0.6066
Entamoeba histolytica hypothetical protein 0.0111 0.047 0.1258
Mycobacterium tuberculosis Probable lipase LipE 0.0307 0.1481 0.1481
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0423 0.2083 0.406
Loa Loa (eye worm) hypothetical protein 0.0022 0.0014 0.0019
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0404 0.1985 0.2734
Trichomonas vaginalis D-aminoacylase, putative 0.0307 0.1481 0.3788
Giardia lamblia Cathepsin B precursor 0.0159 0.0719 0.345
Entamoeba histolytica cysteine proteinase, putative 0.0396 0.1941 0.5198
Loa Loa (eye worm) hypothetical protein 0.0149 0.0669 0.0922
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0307 0.1481 0.1481
Loa Loa (eye worm) hypothetical protein 0.0087 0.0349 0.048
Echinococcus multilocularis cysteine protease 0.0744 0.3734 0.3773
Trichomonas vaginalis penicillin-binding protein, putative 0.0307 0.1481 0.3788
Mycobacterium tuberculosis Probable oxidoreductase 0.0348 0.1692 0.1692
Schistosoma mansoni hypothetical protein 0.0404 0.1985 0.2006
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0159 0.0719 0.1838
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0744 0.3734 0.9551
Echinococcus granulosus dna polymerase eta 0.0102 0.0428 0.0432
Toxoplasma gondii HEAT repeat-containing protein 0.0057 0.0192 0.0514
Schistosoma mansoni cathepsin F (C01 family) 0.0507 0.2512 0.2538
Trypanosoma cruzi hypothetical protein, conserved 0.0307 0.1481 0.2886
Loa Loa (eye worm) hypothetical protein 0.0307 0.1481 0.204
Onchocerca volvulus 0.0028 0.0044 0.008
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0024 0.0023 0.0058
Trypanosoma brucei DNA polymerase kappa, putative 0.0104 0.0434 0.1162
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0744 0.3734 1
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.0022 0.0014 0.0014
Trypanosoma brucei DNA polymerase IV, putative 0.0104 0.0434 0.1162
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0348 0.1692 0.1692
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0159 0.0719 0.1838
Toxoplasma gondii LsmAD domain-containing protein 0.0052 0.0166 0.0446
Giardia lamblia DINP protein human, muc B family 0.0082 0.0324 0.1554
Loa Loa (eye worm) hypothetical protein 0.0307 0.1481 0.204
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0744 0.3734 0.9551
Trypanosoma brucei DNA damage repair protein, putative 0.0023 0.002 0.0054
Brugia malayi MH2 domain containing protein 0.0359 0.1749 0.2409
Loa Loa (eye worm) pigment dispersing factor receptor c 0.1278 0.6489 0.8938
Trichomonas vaginalis glucosylceramidase, putative 0.0538 0.2672 0.6836
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0022 0.0014 0.0036
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0515 0.2557 0.2584
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0744 0.3734 0.9551
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0159 0.0719 0.1925
Brugia malayi Sodium:solute symporter family protein 0.0037 0.0092 0.0127
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0046 0.0137 0.035
Trichomonas vaginalis glutaminase, putative 0.0279 0.1337 0.3419
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0744 0.3734 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0159 0.0719 0.1838
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0041 0.0114 0.0304
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0404 0.1985 0.2006
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0024 0.0023 0.0023
Entamoeba histolytica cysteine proteinase, putative 0.0396 0.1941 0.5198
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0423 0.2083 0.5329
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0396 0.1941 0.1962
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0159 0.0719 0.1838
Giardia lamblia Cysteine protease 0.0159 0.0719 0.345
Leishmania major importin beta-1 subunit, putative 0.0046 0.0137 0.0366
Brugia malayi GH02984p 0.0338 0.1642 0.2262
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0047 0.0145 0.0146
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0507 0.2512 0.4895
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0159 0.0719 0.1838
Loa Loa (eye worm) hypothetical protein 0.0237 0.1122 0.1546
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0037 0.0092 0.0093
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0019 0.002
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0047 0.0145 0.0388
Brugia malayi Calcitonin receptor-like protein seb-1 0.1278 0.6489 0.8938
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0203 0.0545
Plasmodium falciparum serine repeat antigen 1 0.0159 0.0719 0.1925
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.0022 0.0014 0.0019
Brugia malayi MH1 domain containing protein 0.0024 0.0026 0.0036
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0159 0.0719 0.1838
Trypanosoma cruzi trypanothione reductase, putative 0.0137 0.0607 0.1182
Loa Loa (eye worm) MH2 domain-containing protein 0.0024 0.0026 0.0036
Trypanosoma cruzi cysteine peptidase, putative 0.0744 0.3734 0.7278
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0159 0.0719 0.0726
Loa Loa (eye worm) T-complex protein 1 0.0024 0.0023 0.0031
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0313 0.1512 0.1478
Trypanosoma cruzi importin beta-1 subunit, putative 0.0046 0.0137 0.0267
Schistosoma mansoni high-affinity choline transporter 0.0338 0.1642 0.166
Giardia lamblia Cathepsin B precursor 0.0159 0.0719 0.345
Echinococcus granulosus beta LACTamase domain containing family member 0.0307 0.1481 0.1496
Onchocerca volvulus 0.0097 0.0401 0.1041
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0744 0.3734 0.9551
Loa Loa (eye worm) hypothetical protein 0.1427 0.726 1
Trichomonas vaginalis D-aminoacylase, putative 0.0307 0.1481 0.3788
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0159 0.0719 0.1838
Plasmodium vivax serine-repeat antigen (SERA) 0.0159 0.0719 0.1925
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0744 0.3734 0.9551
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0041 0.0114 0.0304
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0047 0.0145 0.0199
Loa Loa (eye worm) hypothetical protein 0.0159 0.0719 0.099
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0047 0.0145 0.0388
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0042 0.0115 0.0308
Loa Loa (eye worm) hypothetical protein 0.0052 0.0166 0.0229
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0159 0.0719 0.1925
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0141 0.0626 0.0633
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0042 0.0115 0.0552
Trichomonas vaginalis glucosylceramidase, putative 0.051 0.2531 0.6473
Trichomonas vaginalis glucosylceramidase, putative 0.0778 0.391 1
Trypanosoma cruzi DNA damage repair protein, putative 0.0023 0.002 0.0039
Trypanosoma brucei PAB1-binding protein , putative 0.0052 0.0166 0.0446
Brugia malayi Papain family cysteine protease containing protein 0.0159 0.0719 0.099
Onchocerca volvulus Cathepsin L homolog 0.0159 0.0719 0.1894
Echinococcus multilocularis solute carrier family 5 0.0037 0.0092 0.0093
Echinococcus granulosus high affinity choline transporter 1 0.0338 0.1642 0.166
Leishmania major cathepsin L-like protease 0.0744 0.3734 1
Schistosoma mansoni cathepsin B (C01 family) 0.0159 0.0719 0.0726
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0024 0.0023 0.0044
Trichomonas vaginalis glucosylceramidase, putative 0.0778 0.391 1
Echinococcus multilocularis tumor protein p63 0.0664 0.3325 0.336
Entamoeba histolytica hypothetical protein 0.0111 0.047 0.1258
Entamoeba histolytica cysteine protease, putative 0.0396 0.1941 0.5198
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0159 0.0719 0.1925
Giardia lamblia TCP-1 chaperonin subunit beta 0.0024 0.0023 0.0109
Brugia malayi Cathepsin L-like precursor 0.0507 0.2512 0.346
Entamoeba histolytica cysteine protease, putative 0.0396 0.1941 0.5198
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.0022 0.0014 0.0019
Echinococcus multilocularis snurportin 1 0.0605 0.302 0.3052
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0159 0.0719 0.345
Trypanosoma brucei DNA polymerase kappa, putative 0.0104 0.0434 0.1162
Trichomonas vaginalis ran, putative 0.0042 0.0115 0.0294
Brugia malayi hypothetical protein 0.0111 0.047 0.0647
Plasmodium vivax hypothetical protein, conserved 0.0307 0.1481 0.3966
Giardia lamblia Cysteine protease 0.0159 0.0719 0.345
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0159 0.0719 0.1838
Schistosoma mansoni cellular tumor antigen P53 0.0097 0.0401 0.0405
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0042 0.0115 0.0158
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0744 0.3734 0.9551
Entamoeba histolytica cysteine proteinase 2 0.0396 0.1941 0.5198
Echinococcus granulosus cathepsin L cysteine protease 0.0396 0.1941 0.1962
Entamoeba histolytica cysteine proteinase, putative 0.0744 0.3734 1
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0047 0.0145 0.0388
Schistosoma mansoni smad1 5 8 and 0.0024 0.0026 0.0026
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.002 0.0039
Leishmania major trypanothione reductase 0.0137 0.0607 0.1624
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0159 0.0719 0.0726
Leishmania major GTP-binding protein, putative 0.0042 0.0115 0.0308
Brugia malayi glutaminase DH11.1 0.0279 0.1337 0.1841
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0022 0.0014 0.0014
Trypanosoma cruzi cysteine peptidase, putative 0.0744 0.3734 0.7278
Brugia malayi T-complex protein 1, beta subunit 0.0024 0.0023 0.0031
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.0022 0.0014 0.0019
Entamoeba histolytica cysteine proteinase, putative 0.0744 0.3734 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0744 0.3734 0.9551
Giardia lamblia DNA damage repair protein 0.0023 0.002 0.0096
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0744 0.3734 1
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0159 0.0719 0.1925
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0778 0.391 0.5385
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0396 0.1941 0.5198
Brugia malayi Thioredoxin reductase 0.0137 0.0607 0.0836
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.003 0.0056 0.0151
Brugia malayi Papain family cysteine protease containing protein 0.0744 0.3734 0.5143
Entamoeba histolytica cysteine protease, putative 0.0396 0.1941 0.5198
Trichomonas vaginalis GTP-binding protein (O) alpha subunit, gnao, putative 0.0022 0.0014 0.0036
Echinococcus multilocularis cathepsin b 0.1014 0.5131 0.5185
Brugia malayi latrophilin 2 splice variant baaae 0.0873 0.4404 0.6066
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0159 0.0719 0.1925
Plasmodium vivax thioredoxin reductase, putative 0.0137 0.0607 0.1624
Schistosoma mansoni cathepsin F (C01 family) 0.0744 0.3734 0.3773
Loa Loa (eye worm) hypothetical protein 0.0037 0.0092 0.0127
Loa Loa (eye worm) hypothetical protein 0.0307 0.1481 0.204
Echinococcus multilocularis GPCR, family 2 0.0404 0.1985 0.2006
Echinococcus multilocularis cathepsin L cysteine protease 0.0744 0.3734 0.3773
Giardia lamblia Cathepsin B precursor 0.0159 0.0719 0.345
Plasmodium falciparum T-complex protein 1 subunit beta 0.0024 0.0023 0.0061
Trichomonas vaginalis chaperonin, putative 0.0024 0.0023 0.0058
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.1427 0.726 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0203 0.0545
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0166 0.0446
Brugia malayi cathepsin L-like cysteine proteinase 0.0159 0.0719 0.099
Mycobacterium ulcerans hypothetical protein 0.0307 0.1481 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0515 0.2557 0.2584
Echinococcus multilocularis cathepsin L 0.0159 0.0719 0.0726
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0096 0.0256
Giardia lamblia Cysteine protease 0.0159 0.0719 0.345
Leishmania major DNA polymerase eta, putative 0.0102 0.0428 0.1145
Onchocerca volvulus 0.0744 0.3734 1
Brugia malayi Cytochrome P450 family protein 0.0031 0.0058 0.0079
Schistosoma mansoni hypothetical protein 0.0404 0.1985 0.2006
Loa Loa (eye worm) thioredoxin reductase 0.0137 0.0607 0.0836
Leishmania major cathepsin L-like protease 0.0744 0.3734 1
Mycobacterium tuberculosis Conserved protein 0.0307 0.1481 0.1481
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0744 0.3734 0.9551
Loa Loa (eye worm) hypothetical protein 0.0052 0.0167 0.023
Brugia malayi cathepsin F-like cysteine proteinase 0.0237 0.1122 0.1546
Trypanosoma brucei DNA polymerase IV, putative 0.0104 0.0434 0.1162
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.0022 0.0014 0.0019
Brugia malayi Muscleblind-like protein 0.0149 0.0669 0.0922
Echinococcus granulosus cathepsin l1 0.0507 0.2512 0.2538
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0022 0.0014 0.0019
Schistosoma mansoni transient receptor potential channel 0.0062 0.0221 0.0223
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0423 0.2083 0.2105
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0022 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0149 0.0669 0.0922
Onchocerca volvulus 0.0744 0.3734 1
Mycobacterium ulcerans beta-lactamase 0.0307 0.1481 1
Brugia malayi G-protein alpha subunit 0.0022 0.0014 0.0019
Schistosoma mansoni ran 0.0042 0.0115 0.0116
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0104 0.0434 0.111
Brugia malayi Papain family cysteine protease containing protein 0.0396 0.1941 0.2674
Echinococcus granulosus sodium:myo inositol cotransporter 0.0037 0.0092 0.0093
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0022 0.0014 0.0014
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.0022 0.0014 0.0014
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0744 0.3734 0.9551
Onchocerca volvulus 0.0307 0.1481 0.3943
Entamoeba histolytica G protein alpha subunit, putative 0.0022 0.0014 0.0037
Schistosoma mansoni GTP-binding protein alpha subunit 0.0022 0.0014 0.0014
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0744 0.3734 0.9551
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0744 0.3734 0.3773
Schistosoma mansoni GTP-binding protein alpha subunit 0.0022 0.0014 0.0014
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1014 0.5131 0.5185
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0159 0.0719 0.1838
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0022 0.0014 0.0014
Schistosoma mansoni hypothetical protein 0.0404 0.1985 0.2006
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0159 0.0719 0.1925
Trypanosoma brucei DNA polymerase eta, putative 0.0102 0.0428 0.1145
Toxoplasma gondii cathepsin CPC2 0.0159 0.0719 0.1925
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0166 0.0324
Plasmodium falciparum serine repeat antigen 3 0.0159 0.0719 0.1925
Echinococcus multilocularis cpg binding protein 0.003 0.0052 0.0053
Brugia malayi cathepsin L-like precursor 0.0507 0.2512 0.346
Entamoeba histolytica cysteine protease, putative 0.0159 0.0719 0.1925
Mycobacterium tuberculosis Conserved protein 0.0307 0.1481 0.1481
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0141 0.0626 0.0633
Entamoeba histolytica cysteine protease, putative 0.0159 0.0719 0.1925
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0159 0.0719 0.0726
Mycobacterium ulcerans glutaminase 0.0279 0.1337 0.9028
Brugia malayi fibroinase precursor 0.0159 0.0719 0.099
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0047 0.0145 0.0977
Brugia malayi Cathepsin L-like precursor 0.0744 0.3734 0.5143
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0159 0.0719 0.0726
Giardia lamblia Cathepsin L precursor 0.0159 0.0719 0.345
Trichomonas vaginalis glucosylceramidase, putative 0.0778 0.391 1
Echinococcus granulosus mothers against decapentaplegic 5 0.0024 0.0026 0.0026
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.002 0.0054
Echinococcus granulosus importin subunit beta 1 0.0057 0.0192 0.0194
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0159 0.0719 0.1925
Entamoeba histolytica cysteine protease, putative 0.0396 0.1941 0.5198
Onchocerca volvulus 0.0744 0.3734 1
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0159 0.0719 0.1925
Treponema pallidum NADH oxidase 0.0047 0.0145 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.008 0.0111
Schistosoma mansoni smad 0.0024 0.0026 0.0026
Trichomonas vaginalis glucosylceramidase, putative 0.051 0.2531 0.6473
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.0022 0.0014 0.0019
Trypanosoma cruzi major cysteine proteinase, putative 0.0159 0.0719 0.1401
Toxoplasma gondii ABC1 family protein 0.0307 0.1481 0.3966
Entamoeba histolytica deoxycytidyl transferase, putative 0.0075 0.0287 0.0769
Schistosoma mansoni trimeric G-protein alpha o subunit 0.0022 0.0014 0.0014
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0075 0.0287 0.029
Giardia lamblia Encystation-specific protease 0.0159 0.0719 0.345
Echinococcus multilocularis cathepsin L cysteine protease 0.0744 0.3734 0.3773
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0159 0.0719 0.0726
Loa Loa (eye worm) hypothetical protein 0.0022 0.0014 0.0019
Leishmania major DNA polymerase kappa, putative 0.0082 0.0324 0.0867
Giardia lamblia Cathepsin B precursor 0.0159 0.0719 0.345
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0042 0.0115 0.0116
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0037 0.0092 0.0093
Schistosoma mansoni hypothetical protein 0.1938 0.9895 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0014 0.0019
Giardia lamblia Cathepsin L precursor 0.0159 0.0719 0.345
Mycobacterium tuberculosis Probable hydrolase 0.0307 0.1481 0.1481
Trypanosoma brucei DNA polymerase kappa, putative 0.0104 0.0434 0.1162
Echinococcus granulosus cysteine protease 0.0396 0.1941 0.1962
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0237 0.1122 0.1546
Brugia malayi Importin beta-1 subunit 0.0057 0.0192 0.0265
Entamoeba histolytica cysteine protease, putative 0.0159 0.0719 0.1925
Echinococcus granulosus solute carrier family 5 0.0037 0.0092 0.0093
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0515 0.2557 0.2584
Echinococcus granulosus cathepsin L cysteine proteinase 0.0744 0.3734 0.3773
Brugia malayi cathepsin L precursor 0.0159 0.0719 0.099
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0744 0.3734 1
Toxoplasma gondii cathepsin CPC1 0.0159 0.0719 0.1925
Loa Loa (eye worm) hypothetical protein 0.0032 0.0064 0.0088
Entamoeba histolytica cysteine protease, putative 0.0396 0.1941 0.5198
Trypanosoma cruzi cysteine peptidase, putative 0.0237 0.1122 0.2187
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0159 0.0719 0.1925
Brugia malayi Cathepsin L-like precursor 0.0744 0.3734 0.5143
Echinococcus multilocularis expressed protein 0.0022 0.0014 0.0014
Trypanosoma brucei DNA polymerase IV, putative 0.0097 0.0398 0.1065
Schistosoma mansoni ran 0.0042 0.0115 0.0116
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0075 0.0287 0.0396
Echinococcus multilocularis cathepsin L 0.0396 0.1941 0.1962
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0159 0.0719 0.099
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0307 0.1481 0.204
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0051 0.0161 0.043
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0744 0.3734 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0396 0.1941 0.4965
Schistosoma mansoni GTP-binding protein (I) alpha subunit gnai 0.0022 0.0014 0.0014
Entamoeba histolytica cysteine protease, putative 0.0159 0.0719 0.1925
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0744 0.3734 0.9551
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0313 0.1512 0.1512
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0159 0.0719 0.1838
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0348 0.1692 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0744 0.3734 0.9551
Schistosoma mansoni terminal deoxycytidyl transferase 0.0075 0.0287 0.029
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0037 0.0092 0.0093
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0307 0.1481 0.1496
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0111 0.047 0.0475
Brugia malayi Latrophilin receptor protein 2 0.0404 0.1985 0.2734
Trichomonas vaginalis glucosylceramidase, putative 0.0778 0.391 1
Trypanosoma cruzi cruzipain precursor, putative 0.0237 0.1122 0.2187
Entamoeba histolytica cysteine protease, putative 0.0396 0.1941 0.5198
Leishmania major DNA damage repair protein, putative 0.0023 0.002 0.0054
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0744 0.3734 1
Plasmodium vivax importin-beta 2, putative 0.0057 0.0192 0.0514
Leishmania major cathepsin L-like protease 0.0744 0.3734 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0047 0.0145 0.0282
Loa Loa (eye worm) cysteine protease 0.0744 0.3734 0.5143
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0024 0.0023 0.0061
Trypanosoma brucei chrX additional, unordered contigs 0.0023 0.002 0.0054
Entamoeba histolytica cysteine protease, putative 0.0396 0.1941 0.5198
Trichomonas vaginalis penicillin-binding protein, putative 0.0307 0.1481 0.3788
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0744 0.3734 0.9551
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0024 0.0026 0.0026
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0159 0.0719 0.345
Trypanosoma brucei DNA polymerase kappa, putative 0.0104 0.0434 0.1162
Trypanosoma brucei cysteine peptidase C (CPC) 0.0423 0.2083 0.5579
Echinococcus granulosus smad 0.0024 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0159 0.0719 0.099
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0111 0.047 0.0475
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0047 0.0145 0.0388
Loa Loa (eye worm) hypothetical protein 0.0095 0.0388 0.0534
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0404 0.1985 0.2006
Mycobacterium tuberculosis Conserved hypothetical protein 0.0075 0.0287 0.0287
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0307 0.1481 0.1481
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0396 0.1941 0.3783
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0159 0.0719 0.0726
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0744 0.3734 1
Leishmania major cathepsin L-like protease 0.0744 0.3734 1
Schistosoma mansoni smad1 5 8 and 0.0024 0.0026 0.0026
Entamoeba histolytica hypothetical protein 0.0111 0.047 0.1258
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0744 0.3734 0.9551
Loa Loa (eye worm) hypothetical protein 0.0095 0.0388 0.0534
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0047 0.0145 0.5
Echinococcus multilocularis mothers against decapentaplegic 5 0.0024 0.0026 0.0026
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0744 0.3734 0.5143
Entamoeba histolytica Ran family GTPase 0.0042 0.0115 0.0308
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0046 0.0137 0.035
Brugia malayi Papain family cysteine protease containing protein 0.0159 0.0719 0.099
Onchocerca volvulus 0.0744 0.3734 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0047 0.0145 0.0282
Echinococcus granulosus cathepsin l1 0.0744 0.3734 0.3773
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0047 0.0145 0.0388
Trypanosoma brucei DNA polymerase kappa, putative 0.0104 0.0434 0.1162
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0035 0.008 0.0081
Echinococcus granulosus GPCR family 2 0.0404 0.1985 0.2006
Mycobacterium ulcerans lipase LipD 0.0307 0.1481 1
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0022 0.0014 0.0036
Plasmodium falciparum serine repeat antigen 2 0.0159 0.0719 0.1925
Trypanosoma brucei DNA polymerase kappa, putative 0.0104 0.0434 0.1162
Loa Loa (eye worm) hypothetical protein 0.0507 0.2512 0.346
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0554 0.2756 0.2785
Mycobacterium ulcerans hypothetical protein 0.0023 0.002 0.0136
Trichomonas vaginalis glucosylceramidase, putative 0.051 0.2531 0.6473
Onchocerca volvulus 0.0307 0.1481 0.3943
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0159 0.0719 0.1925
Leishmania major DNA polymerase eta, putative 0.0051 0.0161 0.043
Toxoplasma gondii thioredoxin reductase 0.0137 0.0607 0.1624
Trypanosoma brucei unspecified product 0.0097 0.0398 0.1065
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.0022 0.0014 0.0019
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0047 0.0145 0.0388
Trichomonas vaginalis glucosylceramidase, putative 0.051 0.2531 0.6473
Plasmodium vivax unspecified product 0.0396 0.1941 0.5198
Plasmodium vivax unspecified product 0.0159 0.0719 0.1925
Trypanosoma brucei DNA polymerase kappa, putative 0.0104 0.0434 0.1162
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0396 0.1941 0.5198
Brugia malayi RNA, U transporter 1 0.0161 0.0731 0.1007
Schistosoma mansoni cathepsin S (C01 family) 0.0159 0.0719 0.0726
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0744 0.3734 0.9551
Trypanosoma cruzi cysteine peptidase, putative 0.0744 0.3734 0.7278
Brugia malayi cathepsin F-like cysteine proteinase 0.0159 0.0719 0.099
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0075 0.0287 0.029
Loa Loa (eye worm) hypothetical protein 0.0059 0.0204 0.0282
Entamoeba histolytica cysteine proteinase, putative 0.0396 0.1941 0.5198
Brugia malayi Cathepsin L-like precursor 0.0744 0.3734 0.5143
Plasmodium falciparum cysteine proteinase falcipain 3 0.0744 0.3734 1
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0096 0.0256
Brugia malayi cathepsin B-like cysteine proteinase 0.1014 0.5131 0.7067
Trichomonas vaginalis G protein (olf) alpha subunit, gnal, putative 0.0022 0.0014 0.0036
Trypanosoma brucei DNA polymerase kappa, putative 0.0082 0.0324 0.0867
Loa Loa (eye worm) hypothetical protein 0.0022 0.0014 0.0019
Brugia malayi Cathepsin L-like precursor 0.0744 0.3734 0.5143
Toxoplasma gondii NADPH-glutathione reductase 0.0047 0.0145 0.0388
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0022 0.0014 0.0014
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0744 0.3734 0.9551
Brugia malayi T-complex protein 1, beta subunit 0.0024 0.0023 0.0031
Plasmodium falciparum glutathione reductase 0.0137 0.0607 0.1624
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0159 0.0719 0.1925
Echinococcus multilocularis smad 0.0024 0.0026 0.0026
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0515 0.2557 0.2584
Toxoplasma gondii t-complex protein beta subunit 0.0024 0.0023 0.0061
Echinococcus granulosus transient receptor potential gamma protein 0.0094 0.0385 0.0389
Loa Loa (eye worm) glutaminase 0.0279 0.1337 0.1841
Echinococcus granulosus expressed protein 0.0022 0.0014 0.0014
Schistosoma mansoni cpg binding protein 0.003 0.0052 0.0053
Echinococcus multilocularis high affinity choline transporter 1 0.0338 0.1642 0.166
Trypanosoma cruzi cruzipain precursor, putative 0.0744 0.3734 0.7278
Trypanosoma cruzi cysteine proteinase, putative 0.0396 0.1941 0.3783
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0042 0.0115 0.0158
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0159 0.0719 0.099
Trypanosoma cruzi cysteine protease, putative 0.0396 0.1941 0.3783
Loa Loa (eye worm) G protein alpha subunit 3 0.0022 0.0014 0.0019
Loa Loa (eye worm) hypothetical protein 0.1014 0.5131 0.7067
Echinococcus multilocularis transient receptor potential gamma protein 0.0094 0.0385 0.0389
Loa Loa (eye worm) hypothetical protein 0.0159 0.0719 0.099
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0744 0.3734 0.9551
Schistosoma mansoni hypothetical protein 0.0605 0.302 0.3052
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0087 0.0349 0.0933
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0022 0.0014 0.0019
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0507 0.2512 0.6424
Entamoeba histolytica cysteine proteinase 1, putative 0.0396 0.1941 0.5198
Loa Loa (eye worm) hypothetical protein 0.0102 0.0428 0.0589
Loa Loa (eye worm) ctsf protein 0.0744 0.3734 0.5143
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0744 0.3734 0.9551
Loa Loa (eye worm) beta-lactamase 0.0307 0.1481 0.204
Schistosoma mansoni cathepsin F (C01 family) 0.0744 0.3734 0.3773
Onchocerca volvulus Cathepsin L homolog 0.0744 0.3734 1
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0423 0.2083 0.5579
Loa Loa (eye worm) fibroinase 0.0744 0.3734 0.5143
Echinococcus multilocularis muscleblind protein 1 0.0149 0.0669 0.0676
Echinococcus multilocularis cathepsin b 0.1014 0.5131 0.5185
Echinococcus multilocularis muscleblind protein 0.0149 0.0669 0.0676
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0087 0.0349 0.0933
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0159 0.0719 0.1925
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0744 0.3734 0.9551
Trypanosoma brucei hypothetical protein, conserved 0.0307 0.1481 0.3966
Echinococcus granulosus GTP binding nuclear protein Ran 0.0042 0.0115 0.0116
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0082 0.0324 0.0324
Giardia lamblia Cathepsin B precursor 0.0423 0.2083 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0047 0.0145 0.0282
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.002 0.0039
Brugia malayi ImpB/MucB/SamB family protein 0.0075 0.0287 0.0396
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0744 0.3734 0.5143
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.0022 0.0014 0.0019
Onchocerca volvulus Glucosylceramidase homolog 0.051 0.2531 0.6765
Mycobacterium tuberculosis Probable reductase 0.0313 0.1512 0.1512
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0047 0.0145 0.0388
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0082 0.0324 0.0867
Schistosoma mansoni hypothetical protein 0.0873 0.4404 0.4451
Loa Loa (eye worm) MH2 domain-containing protein 0.0359 0.1749 0.2409
Leishmania major DNA polymerase kappa, putative 0.0023 0.002 0.0054
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1014 0.5131 0.5185
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.0205 0.0207
Loa Loa (eye worm) hypothetical protein 0.0097 0.0401 0.0553
Echinococcus granulosus short transient receptor potential channel 6 0.0062 0.0221 0.0223
Giardia lamblia Cathepsin L precursor 0.0159 0.0719 0.345
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0313 0.1512 0.1512
Trypanosoma brucei unspecified product 0.0052 0.0167 0.0447
Brugia malayi Cathepsin L-like precursor 0.0744 0.3734 0.5143
Mycobacterium tuberculosis Probable esterase LipL 0.0307 0.1481 0.1481
Schistosoma mansoni cathepsin s 0.0237 0.1122 0.1134
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0515 0.2557 0.3522
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0744 0.3734 0.9551
Schistosoma mansoni DNA polymerase IV / kappa 0.0023 0.002 0.002
Giardia lamblia Cathepsin B precursor 0.0423 0.2083 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.0192 0.0265
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0041 0.0114 0.0304
Brugia malayi polk-prov protein 0.0052 0.0167 0.023
Leishmania major cathepsin L-like protease 0.0744 0.3734 1
Onchocerca volvulus 0.0744 0.3734 1
Trichomonas vaginalis GTP-binding protein (q) alpha-11 subunit, gna11, putative 0.0022 0.0014 0.0036
Echinococcus granulosus cathepsin b 0.1014 0.5131 0.5185
Trypanosoma cruzi cysteine peptidase, putative 0.0396 0.1941 0.3783
Loa Loa (eye worm) transcription factor SMAD2 0.0359 0.1749 0.2409
Plasmodium falciparum serine repeat antigen 7 0.0159 0.0719 0.1925
Schistosoma mansoni hypothetical protein 0.0404 0.1985 0.2006
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0022 0.0014 0.0036
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0515 0.2557 0.2584
Plasmodium falciparum DNA repair protein REV1, putative 0.0023 0.002 0.0054
Echinococcus granulosus sodium:glucose cotransporter 2 0.0037 0.0092 0.0093
Loa Loa (eye worm) hypothetical protein 0.0237 0.1122 0.1546
Schistosoma mansoni transcription factor LCR-F1 0.0111 0.047 0.0475
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0744 0.3734 0.3773
Brugia malayi glutathione reductase 0.0137 0.0607 0.0836
Plasmodium vivax glutathione reductase, putative 0.0137 0.0607 0.1624
Loa Loa (eye worm) hypothetical protein 0.0159 0.0719 0.099
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0047 0.0145 1
Trypanosoma cruzi cysteine peptidase, putative 0.0744 0.3734 0.7278
Trypanosoma cruzi DNA polymerase eta, putative 0.0051 0.0161 0.0313
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0166 0.0324
Entamoeba histolytica cysteine protease, putative 0.0396 0.1941 0.5198
Onchocerca volvulus 0.0744 0.3734 1
Giardia lamblia Cathepsin L-like protease 0.0159 0.0719 0.345
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0037 0.0092 0.0093

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) = 0.305 uM In vitro concentration required for 50% inhibition of growth of human leukemia cell line CCRF-CEM with hPAP (0.2 unit/mL) ChEMBL. 11597404
GI50 (functional) = 195 uM In vitro concentration required for 50% inhibition of growth of human leukemia cell line CCRF-CEM without hPAP (0.2 unit/mL) ChEMBL. 11597404
Ratio (functional) = 639 Ratio of GI50 without hPAP/ GI50 with hPAP ChEMBL. 11597404

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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