Detailed information for compound 1611395

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 373.487 | Formula: C25H27NO2
  • H donors: 1 H acceptors: 0 LogP: 4.88 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: C(NCC1CCC(O1)(c1ccccc1)c1ccccc1)COc1ccccc1
  • InChi: 1S/C25H27NO2/c1-4-10-21(11-5-1)25(22-12-6-2-7-13-22)17-16-24(28-25)20-26-18-19-27-23-14-8-3-9-15-23/h1-15,24,26H,16-20H2
  • InChiKey: STDDNPFGFREFHT-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0157 0.1742 0.1739
Toxoplasma gondii target of rapamycin (TOR), putative 0.0617 0.7085 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0491 0.5619 0.5882
Loa Loa (eye worm) phosphatidylinositol 3 0.0278 0.315 0.3295
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.003 0.0268 0.0276
Trypanosoma cruzi target of rapamycin kinase 3 0.0661 0.759 0.7944
Onchocerca volvulus Serine\/threonine kinase homolog 0.0093 0.1002 1
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0054 0.0542 1
Schistosoma mansoni voltage-gated potassium channel 0.0011 0.0043 0.0041
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.083 0.9553 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.003 0.0268 0.0264
Leishmania major phosphatidylinositol kinase, putative 0.0054 0.0541 0.0561
Loa Loa (eye worm) hypothetical protein 0.0008 0.0015 0.0011
Loa Loa (eye worm) hypothetical protein 0.0095 0.1019 0.1063
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0049 0.0047
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0111 0.1212 0.1264
Plasmodium vivax hypothetical protein, conserved 0.0016 0.011 0.1956
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0049 0.0047
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0157 0.1742 0.182
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0093 0.1002 0.0998
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0054 0.0541 0.0563
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0049 0.0047
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0093 0.1002 0.1045
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0054 0.0541 0.0563
Trichomonas vaginalis PIKK family atypical protein kinase 0.0278 0.315 0.3298
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0054 0.0541 0.0757
Trypanosoma brucei PAB1-binding protein , putative 0.0053 0.053 0.055
Brugia malayi exodeoxyribonuclease III family protein 0.0017 0.0119 0.0121
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.003 0.0268 0.0276
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0054 0.0541 0.0563
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0054 0.0541 0.0561
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0054 0.0542 0.0564
Loa Loa (eye worm) hypothetical protein 0.0011 0.0049 0.0047
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0121 0.1328 0.1325
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0049 0.0047
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0054 0.0541 0.0561
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0278 0.315 0.3295
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0157 0.1742 0.182
Loa Loa (eye worm) G protein alpha subunit 3 0.0008 0.0015 0.0011
Loa Loa (eye worm) glutaminase 0.0306 0.3469 0.3628
Trichomonas vaginalis PIKK family atypical protein kinase 0.0223 0.2505 0.2622
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0274 0.0282
Trichomonas vaginalis PIKK family atypical protein kinase 0.083 0.9553 1
Echinococcus granulosus Smad4 0.0008 0.001 0.0006
Loa Loa (eye worm) Smad1 0.0008 0.001 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0278 0.315 0.3298
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0017 0.0119 0.0121
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0054 0.0542 0.155
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0054 0.0541 0.0538
Schistosoma mansoni transcription factor LCR-F1 0.0068 0.0714 0.0743
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0049 0.0047
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0017 0.0119 0.0121
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0054 0.0541 0.0563
Trichomonas vaginalis PIKK family atypical protein kinase 0.0278 0.315 0.3298
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0049 0.0047
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0054 0.0541 0.9986
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0054 0.0541 0.0567
Loa Loa (eye worm) hypothetical protein 0.0011 0.0049 0.0047
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0054 0.0541 0.0561
Entamoeba histolytica hypothetical protein 0.0054 0.0541 0.0561
Brugia malayi MH2 domain containing protein 0.0114 0.1245 0.1299
Trypanosoma cruzi polo-like protein kinase, putative 0.0093 0.1002 0.1044
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0054 0.0542 0.0562
Toxoplasma gondii histone deacetylase SIR2 0.0016 0.011 0.0148
Echinococcus multilocularis Smad4 0.0008 0.001 0.0006
Loa Loa (eye worm) hypothetical protein 0.0295 0.3338 0.3491
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0157 0.1742 0.1819
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0054 0.0541 0.0561
Echinococcus granulosus chromatin regulatory protein sir2 0.0111 0.1212 0.1265
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0049 0.0047
Onchocerca volvulus 0.0008 0.0015 0.0093
Brugia malayi G-protein alpha subunit 0.0008 0.0015 0.0011
Trichomonas vaginalis PIKK family atypical protein kinase 0.0491 0.5619 0.5882
Leishmania major phosphatidylinositol 4-kinase, putative 0.0054 0.0541 0.0561
Entamoeba histolytica hypothetical protein 0.0068 0.0714 0.0742
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0456 0.0477
Onchocerca volvulus 0.003 0.0274 0.2692
Trichomonas vaginalis PIKK family atypical protein kinase 0.0496 0.5676 0.5942
Treponema pallidum exodeoxyribonuclease (exoA) 0.0017 0.0119 0.2122
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0157 0.1742 0.182
Giardia lamblia Transcriptional regulator, Sir2 family 0.0016 0.011 0.011
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0054 0.0541 0.0567
Loa Loa (eye worm) hypothetical protein 0.0065 0.0671 0.0699
Loa Loa (eye worm) hypothetical protein 0.0011 0.0049 0.0047
Schistosoma mansoni immunophilin 0.0046 0.0456 0.0474
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0054 0.0541 0.0567
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0054 0.0541 0.0561
Schistosoma mansoni immunophilin 0.0054 0.0542 0.0564
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.083 0.9553 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.019 0.2129 0.2225
Trichomonas vaginalis PIKK family atypical protein kinase 0.0157 0.1742 0.1823
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-33 0.0007 0.0005 0.0002
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0049 0.0047
Trichomonas vaginalis PIKK family atypical protein kinase 0.0617 0.7085 0.7416
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0016 0.011 0.0116
Echinococcus multilocularis smad 0.0008 0.001 0.0006
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0054 0.0541 0.0561
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0054 0.0541 0.0567
Loa Loa (eye worm) phosphatidylinositol 3 0.0054 0.0541 0.0563
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0054 0.0542 0.0538
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0049 0.0047
Brugia malayi nuclear hormone receptor 0.0011 0.0049 0.0047
Trichomonas vaginalis ap endonuclease, putative 0.0017 0.0119 0.0125
Entamoeba histolytica hypothetical protein 0.0054 0.0541 0.0561
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0037 0.0345 0.0341
Schistosoma mansoni hypothetical protein 0.003 0.0268 0.0276
Loa Loa (eye worm) hypothetical protein 0.0011 0.0049 0.0047
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0049 0.0047
Trichomonas vaginalis PIKK family atypical protein kinase 0.083 0.9553 1
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0054 0.0542 0.0567
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0049 0.0045
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0011 0.0049 0.0436
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0037 0.0345 0.0357
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0157 0.1742 0.182
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0007 0.0004 0.0004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0278 0.315 0.3298
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0049 0.0047
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0049 0.0045
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0016 0.011 0.0116
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0049 0.0047
Loa Loa (eye worm) phosphatidylinositol 3 0.0054 0.0541 0.0563
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0541 0.0567
Toxoplasma gondii LsmAD domain-containing protein 0.0053 0.053 0.0742
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.0008 0.0015 0.0011
Trichomonas vaginalis PIKK family atypical protein kinase 0.0539 0.6174 0.6462
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0008 0.0015 0.0011
Trichomonas vaginalis PIKK family atypical protein kinase 0.0448 0.5114 0.5353
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0049 0.0045
Schistosoma mansoni chromatin regulatory protein sir2 0.0111 0.1212 0.1265
Echinococcus granulosus dnaJ subfamily B 0.0434 0.496 0.519
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0008 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0295 0.3338 0.3491
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.083 0.9553 1
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0111 0.1212 0.1264
Echinococcus multilocularis serine protein kinase ATM 0.0157 0.1742 0.1739
Schistosoma mansoni trimeric G-protein alpha o subunit 0.0008 0.0015 0.0011
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0049 0.0047
Mycobacterium tuberculosis Transcriptional regulatory protein 0.0016 0.011 0.1959
Brugia malayi hypothetical protein 0.0053 0.053 0.0551
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0024 0.0194 0.019
Giardia lamblia Hypothetical protein 0.0054 0.0541 0.0561
Echinococcus multilocularis dnaJ subfamily B 0.0434 0.496 0.4958
Loa Loa (eye worm) hypothetical protein 0.0011 0.0049 0.0047
Loa Loa (eye worm) transcriptional regulator 0.0111 0.1212 0.1265
Schistosoma mansoni chromatin regulatory protein sir2 0.0016 0.011 0.0111
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0016 0.011 0.0116
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0049 0.0047
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0054 0.0541 0.0757
Leishmania major sir2-family protein-like protein 0.0016 0.011 0.011
Echinococcus multilocularis expressed protein 0.0008 0.0015 0.0011
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0046 0.0456 0.0453
Schistosoma mansoni hypothetical protein 0.003 0.0268 0.0276
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0049 0.0045
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.083 0.9553 1
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0054 0.0541 0.0757
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.1002 0.1049
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-13, BmFKBP-13 0.0007 0.0005 0.0002
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0054 0.0541 0.9986
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0054 0.0542 0.0564
Schistosoma mansoni cpg binding protein 0.0032 0.0294 0.0304
Trichomonas vaginalis fk506-binding protein, putative 0.0007 0.0005 0.0006
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.0054 0.0542 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0017 0.0119 0.0119
Schistosoma mansoni chromatin regulatory protein sir2 0.0016 0.011 0.0111
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.0008 0.0015 0.0011
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0054 0.0541 0.0563
Loa Loa (eye worm) phosphatidylinositol 3 0.0054 0.0541 0.0563
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-30 0.0007 0.0005 0.0002
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0011 0.0043 0.0041
Brugia malayi NAD-dependent deacetylase SIRT1 0.0016 0.011 0.0111
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.083 0.9553 1
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0008 0.0015 0.0011
Entamoeba histolytica hypothetical protein 0.0068 0.0714 0.0742
Schistosoma mansoni chromatin regulatory protein sir2 0.0111 0.1212 0.1265
Brugia malayi glutaminase DH11.1 0.0306 0.3469 0.3628
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0029 0.0026
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0054 0.0541 0.0563
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0008 0.0015 0.0011
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0049 0.0047
Onchocerca volvulus 0.0011 0.0049 0.0436
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.003 0.0268 0.0276
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0054 0.0541 0.0561
Schistosoma mansoni hypothetical protein 0.0121 0.1328 0.1387
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0103 0.112 0.1168
Trichomonas vaginalis PIKK family atypical protein kinase 0.066 0.7582 0.7937
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0049 0.0047
Trypanosoma brucei SIR2-like protein 4, putative 0.0016 0.011 0.011
Giardia lamblia GTOR 0.083 0.9553 1
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0111 0.1212 0.1269
Loa Loa (eye worm) hypothetical protein 0.0016 0.011 0.0111
Schistosoma mansoni coup transcription factor 0.0011 0.0049 0.0047
Schistosoma mansoni GTP-binding protein alpha subunit 0.0008 0.0015 0.0011
Plasmodium falciparum transcriptional regulatory protein sir2b 0.0016 0.011 0.1956
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0054 0.0541 0.0561
Leishmania major NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe 0.0016 0.011 0.011
Schistosoma mansoni ap endonuclease 0.0017 0.0119 0.0121
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0095 0.1019 0.1063
Echinococcus multilocularis 0.0007 0.0005 0.0001
Loa Loa (eye worm) phosphatidylinositol 3 0.0054 0.0541 0.0563
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0049 0.0047
Loa Loa (eye worm) hypothetical protein 0.0053 0.053 0.0551
Trypanosoma cruzi polo-like protein kinase, putative 0.0093 0.1002 0.1044
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.0054 0.0542 1
Brugia malayi MH1 domain containing protein 0.0008 0.001 0.0006
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0054 0.0541 0.0563
Onchocerca volvulus 0.0008 0.0015 0.0093
Echinococcus multilocularis fk506 binding protein 0.0054 0.0542 0.0538
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0008 0.0015 0.0011
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0049 0.0045
Trypanosoma brucei polo-like protein kinase 0.0093 0.1002 0.1044
Plasmodium falciparum transcriptional regulatory protein sir2a 0.0016 0.011 0.1956
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0054 0.0542 0.0562
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.0008 0.0015 0.0011
Trichomonas vaginalis GTP-binding protein (q) alpha-11 subunit, gna11, putative 0.0008 0.0015 0.0015
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0054 0.0542 0.0562
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0054 0.0541 0.9986
Schistosoma mansoni chromatin regulatory protein sir2 0.0016 0.011 0.0111
Schistosoma mansoni voltage-gated potassium channel 0.0011 0.0043 0.0041
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0054 0.0541 0.0567
Trichomonas vaginalis PIKK family atypical protein kinase 0.083 0.9553 1
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0054 0.0541 0.9986
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0054 0.0541 0.0563
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0007 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0121 0.1328 0.1387
Loa Loa (eye worm) hypothetical protein 0.003 0.0268 0.0276
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0054 0.0541 0.0563
Schistosoma mansoni smad 0.0008 0.001 0.0006
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0049 0.0047
Schistosoma mansoni hypothetical protein 0.003 0.0268 0.0276
Giardia lamblia Sirtuin type 2 0.0016 0.011 0.011
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.083 0.9553 0.9553
Schistosoma mansoni smad1 5 8 and 0.0008 0.001 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0496 0.5676 0.5942
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0049 0.0047
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.0016 0.011 0.0111
Plasmodium vivax hypothetical protein, conserved 0.0054 0.0541 0.9986
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0054 0.0542 0.0564
Leishmania major hypothetical protein, conserved 0.0053 0.053 0.055
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0054 0.0541 0.0561
Trichomonas vaginalis PIKK family atypical protein kinase 0.066 0.7582 0.7937
Brugia malayi latrophilin 2 splice variant baaae 0.0065 0.0671 0.0699
Schistosoma mansoni hypothetical protein 0.0065 0.0671 0.0699
Trichomonas vaginalis PIKK family atypical protein kinase 0.0157 0.1742 0.1823
Brugia malayi Smad1 0.0008 0.001 0.0006
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.001 0.0006
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.001 0.0006
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0054 0.0541 0.0561
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0049 0.0045
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0011 0.0043 0.0041
Echinococcus granulosus voltage gated potassium channel 0.0011 0.0043 0.0041
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0017 0.0119 0.2122
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0008 0.0004
Echinococcus granulosus cpg binding protein 0.0032 0.0294 0.0304
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0175 0.195 0.2747
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.0008 0.0015 0.0011
Schistosoma mansoni ap endonuclease 0.0017 0.0119 0.0121
Entamoeba histolytica hypothetical protein 0.0068 0.0714 0.0742
Onchocerca volvulus Protein ultraspiracle homolog 0.0011 0.0049 0.0436
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0054 0.0542 0.0564
Schistosoma mansoni hypothetical protein 0.003 0.0268 0.0276
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0028 0.0025
Schistosoma mansoni voltage-gated potassium channel 0.004 0.0384 0.0398
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0008 0.0015 0.0011
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0054 0.0541 0.0561
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.003 0.0268 0.0264
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0157 0.1742 0.1819
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0054 0.0541 0.0567
Echinococcus granulosus serine protein kinase ATM 0.0157 0.1742 0.182
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0016 0.011 0.0116
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.083 0.9553 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.003 0.0268 0.0276
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0049 0.0047
Trichomonas vaginalis PIKK family atypical protein kinase 0.0617 0.7085 0.7416
Brugia malayi hypothetical protein 0.0008 0.0015 0.0011
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0456 0.0477
Plasmodium vivax hypothetical protein 0.0054 0.0541 0.9986
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0049 0.0047
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0054 0.0541 0.0563
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0049 0.0047
Loa Loa (eye worm) hypothetical protein 0.0008 0.0015 0.0011
Leishmania major peptidylprolyl isomerase-like protein 0.0054 0.0542 0.0562
Schistosoma mansoni kinase 0.0047 0.047 0.0488
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0008 0.0015 0.0011
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0049 0.0047
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0049 0.0047
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0054 0.0541 0.0563
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0054 0.0541 0.0567
Schistosoma mansoni immunophilin 0.0054 0.0542 0.0564
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.0008 0.0015 0.0011
Echinococcus multilocularis FK506 binding protein 8, 38 kDa 0.0007 0.0005 0.0001
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0278 0.315 0.3294
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.0016 0.011 0.0106
Echinococcus granulosus FK506 binding protein 2 0.0007 0.0005 0.0002
Brugia malayi Latrophilin receptor protein 2 0.003 0.0268 0.0276
Leishmania major fk506-binding protein 1-like protein 0.0054 0.0542 0.0562
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.0008 0.0015 0.0011
Entamoeba histolytica serine/threonine protein kinase, putative 0.0093 0.1002 0.1044
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0008 0.0015 0.0011
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0049 0.0047
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.019 0.2129 0.2225
Loa Loa (eye worm) glutaminase 2 0.0306 0.3469 0.3628
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0008 0.0015 0.0011
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0054 0.0541 0.0757
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0054 0.0541 0.0561
Trichomonas vaginalis PIKK family atypical protein kinase 0.0448 0.5122 0.5361
Entamoeba histolytica hypothetical protein 0.0054 0.0541 0.0561
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0054 0.0541 0.9986
Trichomonas vaginalis PIKK family atypical protein kinase 0.0448 0.5114 0.5353
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0016 0.011 0.011
Trichomonas vaginalis ap endonuclease, putative 0.0017 0.0119 0.0125
Entamoeba histolytica NAD-dependent deacetylase 1, putative 0.0016 0.011 0.011
Trichomonas vaginalis PIKK family atypical protein kinase 0.0157 0.1742 0.1823
Trichomonas vaginalis G protein (olf) alpha subunit, gnal, putative 0.0008 0.0015 0.0015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0617 0.7085 0.7416
Schistosoma mansoni GTP-binding protein alpha subunit 0.0008 0.0015 0.0011
Loa Loa (eye worm) transcriptional regulator 0.0016 0.011 0.0111
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0016 0.011 0.0116
Loa Loa (eye worm) hypothetical protein 0.0008 0.0015 0.0011
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0054 0.0541 0.0538
Brugia malayi hypothetical protein 0.0034 0.0314 0.0325
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.019 0.2129 0.2225
Schistosoma mansoni smad1 5 8 and 0.0008 0.001 0.0006
Schistosoma mansoni voltage-gated potassium channel 0.004 0.0384 0.0398
Trichomonas vaginalis fk506-binding protein, putative 0.0007 0.0005 0.0006
Brugia malayi transcriptional regulator, Sir2 family protein 0.0016 0.011 0.0111
Loa Loa (eye worm) hypothetical protein 0.0007 0.0005 0.0002
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0054 0.0541 0.0563
Brugia malayi serine/threonine-protein kinase plk-2 0.0093 0.1002 0.1045
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.083 0.9553 1
Trichomonas vaginalis glutaminase, putative 0.0306 0.3469 0.3631
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0111 0.1212 0.1264
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0016 0.011 0.0116
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.0008 0.0015 0.0011
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0049 0.0047
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0049 0.0047
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.0016 0.011 0.0111
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0017 0.0119 0.0329
Echinococcus multilocularis GPCR, family 2 0.003 0.0268 0.0264
Mycobacterium ulcerans Sir2-like regulatory protein 0.0016 0.011 0.0303
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.0111 0.1212 0.1265
Loa Loa (eye worm) hypothetical protein 0.0008 0.0015 0.0011
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.053 0.055
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0054 0.0541 0.0538
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0024 0.0194 0.0199
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0278 0.315 0.3295
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0029 0.0025
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.001 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0496 0.5676 0.5942
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0016 0.011 0.0116
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0054 0.0542 0.0564
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0054 0.0541 0.0563
Toxoplasma gondii FATC domain-containing protein 0.0157 0.1742 0.2453
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0005 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0049 0.0047
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0054 0.0541 0.0561
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0054 0.0541 0.0563
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.001 0.0006
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0049 0.0045
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0054 0.0542 0.0567
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-13 0.0007 0.0005 0.0002
Loa Loa (eye worm) hypothetical protein 0.0169 0.1883 0.1968
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0017 0.0119 0.0115
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-30, BmFKBP-30 0.0007 0.0005 0.0002
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0049 0.0047
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.0008 0.0015 0.0011
Schistosoma mansoni cpg binding protein 0.003 0.0274 0.0282
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0054 0.0541 0.0567
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0008 0.0004
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0054 0.0542 0.0562
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0278 0.315 0.3294
Schistosoma mansoni hypothetical protein 0.0434 0.496 0.519
Brugia malayi MH1 domain containing protein 0.0008 0.001 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0448 0.5122 0.5361
Loa Loa (eye worm) phosphatidylinositol 3 0.0054 0.0541 0.0563
Loa Loa (eye worm) hypothetical protein 0.0157 0.1742 0.182
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0049 0.0047
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0054 0.0541 0.0563
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0157 0.1742 0.1819
Loa Loa (eye worm) hypothetical protein 0.0175 0.195 0.2038
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.1002 0.1049
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0017 0.0119 0.0119
Echinococcus multilocularis chromatin regulatory protein sir2 0.0111 0.1212 0.1208
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0157 0.1742 0.1819
Leishmania major hypothetical protein, conserved 0.0054 0.0541 0.0561
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0016 0.011 0.0111
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0541 0.0567
Loa Loa (eye worm) hypothetical protein 0.0054 0.0541 0.0563
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0049 0.0047
Trichomonas vaginalis PIKK family atypical protein kinase 0.0617 0.7085 0.7416
Trichomonas vaginalis PIKK family atypical protein kinase 0.0448 0.5122 0.5361
Onchocerca volvulus 0.0054 0.0541 0.5378
Loa Loa (eye worm) hypothetical protein 0.0032 0.0289 0.0299
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0017 0.0119 0.0119
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0016 0.011 0.011
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0046 0.0456 0.0474
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.0008 0.0015 0.0011
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.019 0.2129 0.2225
Loa Loa (eye worm) sirtuin 4 0.0016 0.011 0.0111
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0054 0.0541 0.0563
Trichomonas vaginalis PIKK family atypical protein kinase 0.0709 0.8145 0.8526
Schistosoma mansoni fk506 binding protein 0.0007 0.0005 0.0002
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0049 0.0047
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0008 0.0015 0.0011
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.083 0.9553 1
Brugia malayi MH2 domain containing protein 0.0008 0.001 0.0006
Loa Loa (eye worm) hypothetical protein 0.0054 0.0541 0.0563
Schistosoma mansoni hypothetical protein 0.0054 0.0541 0.0563
Entamoeba histolytica hypothetical protein 0.0068 0.0714 0.0742
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0111 0.1212 0.1269
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0093 0.1002 0.1044
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0121 0.1328 0.1387
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0037 0.0345 0.0357
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.0016 0.011 0.0106
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0011 0.0043 0.0039
Brugia malayi hypothetical protein 0.0068 0.0714 0.0743
Echinococcus multilocularis cpg binding protein 0.0032 0.0294 0.029
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0661 0.759 0.7944
Brugia malayi MH2 domain containing protein 0.0008 0.001 0.0006
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0008 0.0015 0.0015
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0054 0.0541 0.0567
Brugia malayi steroid hormone receptor 0.0011 0.0049 0.0047
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.1002 0.1049
Brugia malayi CXXC zinc finger family protein 0.003 0.0274 0.0282
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0068 0.0714 0.0743
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0049 0.0047
Schistosoma mansoni chromatin regulatory protein sir2 0.0111 0.1212 0.1265
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.083 0.9553 1
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0054 0.0542 0.0564
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.019 0.2129 0.2225
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.0008 0.0015 0.0011
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0054 0.0541 0.0757
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0054 0.0541 0.9986
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0054 0.0541 0.0567
Toxoplasma gondii histone deacetylase SIR2-like 0.0016 0.011 0.0148
Plasmodium vivax ataxin-2 like protein, putative 0.0053 0.053 0.9782
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0054 0.0541 0.0561
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0068 0.0714 0.071
Echinococcus multilocularis Zinc finger, PHD finger 0.0054 0.0541 0.0538
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0016 0.011 0.011
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0054 0.0541 0.9986
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0054 0.0541 0.0538
Loa Loa (eye worm) hypothetical protein 0.0011 0.0049 0.0047
Echinococcus multilocularis muscleblind protein 0.0295 0.3338 0.3335
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0049 0.0047
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0095 0.1019 0.1063
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0008 0.0004
Schistosoma mansoni hypothetical protein 0.0068 0.0714 0.0743
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.083 0.9553 1
Loa Loa (eye worm) phosphatidylinositol kinase 0.0054 0.0541 0.0563
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0093 0.1002 0.1045
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0008 0.0015 0.0011
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0054 0.0542 0.0562
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0017 0.0119 0.0119
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0008 0.0015 0.0015
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0278 0.315 0.3294
Entamoeba histolytica hypothetical protein 0.0054 0.0541 0.0561
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0054 0.0541 0.0563
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0008 0.0015 0.0011
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0054 0.0541 0.0561
Echinococcus granulosus muscleblind protein 0.0295 0.3338 0.3491
Loa Loa (eye worm) transcriptional regulator 0.0016 0.011 0.0111
Schistosoma mansoni fkbp-rapamycin associated protein 0.0157 0.1742 0.182
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0054 0.0541 0.0563
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0008 0.0015 0.0011
Giardia lamblia NAD-dependent histone deacetylase Sir2 0.0016 0.011 0.011
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0049 0.0045
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0054 0.0541 0.0561
Entamoeba histolytica hypothetical protein 0.0157 0.1742 0.1819
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0017 0.0119 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.053 0.055
Schistosoma mansoni GTP-binding protein (I) alpha subunit gnai 0.0008 0.0015 0.0011
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.0008 0.0015 0.0011
Brugia malayi Calcitonin receptor-like protein seb-1 0.0095 0.1019 0.1063
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0054 0.0541 0.0563
Echinococcus multilocularis voltage gated potassium channel 0.0011 0.0043 0.0039
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0037 0.0345 0.0357
Giardia lamblia Hypothetical protein 0.0111 0.1212 0.1264
Giardia lamblia Kinase, PLK 0.0093 0.1002 0.1044
Brugia malayi transcriptional regulator, Sir2 family protein 0.0111 0.1212 0.1265
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0008 0.0015 0.0011
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.1002 0.1049
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0278 0.315 0.3294
Trichomonas vaginalis PIKK family atypical protein kinase 0.0448 0.5114 0.5353
Leishmania major phosphatidylinositol kinase related protein, putative 0.0054 0.0541 0.0561
Leishmania major phosphatidylinositol 3-kinase, putative 0.0278 0.315 0.3294
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0054 0.0541 0.0561
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0054 0.0541 0.0561
Entamoeba histolytica hypothetical protein, conserved 0.0016 0.011 0.011
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0008 0.0015 0.0011
Leishmania major hypothetical protein, unknown function 0.0054 0.0541 0.0561
Trichomonas vaginalis PIKK family atypical protein kinase 0.0448 0.5122 0.5361
Trichomonas vaginalis immunophilin, putative 0.0054 0.0542 0.0567
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0008 0.0015 0.0011
Loa Loa (eye worm) hypothetical protein 0.0011 0.0049 0.0047
Mycobacterium ulcerans glutaminase 0.0306 0.3469 1
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0054 0.0542 0.0562
Plasmodium vivax NAD-dependent deacetylase, putative 0.0016 0.011 0.1956
Schistosoma mansoni hypothetical protein 0.0024 0.0194 0.0199
Loa Loa (eye worm) phosphatidylinositol 3 0.083 0.9553 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0317 0.0332
Trichomonas vaginalis GTP-binding protein (O) alpha subunit, gnao, putative 0.0008 0.0015 0.0015
Brugia malayi nuclear receptor NHR-88 0.0011 0.0049 0.0047
Loa Loa (eye worm) hypothetical protein 0.0011 0.0049 0.0047
Echinococcus multilocularis muscleblind protein 1 0.0295 0.3338 0.3335
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0049 0.0047
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0054 0.0541 0.0561
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.1002 0.1049
Trichomonas vaginalis PIKK family atypical protein kinase 0.0557 0.6382 0.668
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0049 0.0047
Brugia malayi Muscleblind-like protein 0.0295 0.3338 0.3491
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.0008 0.0015 0.0011
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0049 0.0047
Trichomonas vaginalis PIKK family atypical protein kinase 0.066 0.7582 0.7937
Chlamydia trachomatis peptidyl-prolyl cis-trans isomerase 0.0007 0.0005 0.5
Echinococcus granulosus expressed protein 0.0008 0.0015 0.0011
Schistosoma mansoni smad1 5 8 and 0.0008 0.001 0.0006
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0393 0.4476 0.4682
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0049 0.0047
Trichomonas vaginalis PIKK family atypical protein kinase 0.0103 0.112 0.1173
Loa Loa (eye worm) transcription factor SMAD2 0.0114 0.1245 0.1299
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0345 0.3921 0.4101
Loa Loa (eye worm) FKBP5 protein 0.0054 0.0542 0.0564
Brugia malayi transcriptional regulator, Sir2 family protein 0.0016 0.011 0.0111
Trypanosoma brucei Silent information regulator 2 related protein 1 0.0111 0.1212 0.1264
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0017 0.0119 0.0119
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0049 0.0047
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0005 0.0006
Leishmania major silent information regulator 2, putative 0.0111 0.1212 0.1264
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0054 0.0541 0.0561
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0049 0.0047
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0317 0.0332
Loa Loa (eye worm) hypothetical protein 0.0008 0.0015 0.0011
Schistosoma mansoni glutaminase 0.0306 0.3469 0.3628
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0054 0.0541 0.0563
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0008 0.0015 0.0011
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0054 0.0542 0.0562
Schistosoma mansoni cpg binding protein 0.0032 0.0294 0.0304
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0049 0.0047
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0661 0.759 0.7944
Trichomonas vaginalis conserved hypothetical protein 0.0103 0.112 0.1173
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.019 0.2129 0.2225
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.019 0.2129 0.2126
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.0111 0.1212 0.1208
Trichomonas vaginalis fk506-binding protein, putative 0.0054 0.0542 0.0567
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0054 0.0541 0.0567
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.0054 0.0542 0.0562
Onchocerca volvulus 0.0008 0.0015 0.0093
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0016 0.011 0.0106
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0054 0.0541 0.0563
Trichomonas vaginalis PIKK family atypical protein kinase 0.0617 0.7085 0.7416
Trichomonas vaginalis PIKK family atypical protein kinase 0.0617 0.7085 0.7416
Onchocerca volvulus 0.0054 0.0541 0.5378
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0049 0.0047
Entamoeba histolytica protein kinase rad3, putative 0.0157 0.1742 0.1819
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0054 0.0541 0.0561
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0278 0.315 0.3294
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0278 0.315 0.3295
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0054 0.0541 0.0563
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0054 0.0541 0.0538
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.001 0.0006
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0029 0.0026
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.019 0.2129 0.2126
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.083 0.9553 1
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0016 0.011 0.0116
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.001 0.0006
Trichomonas vaginalis fk506 binding protein, putative 0.0007 0.0005 0.0006
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0054 0.0542 0.0562
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0054 0.0541 0.0538
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0049 0.0047
Giardia lamblia Phosphatidylinositol 4-kinase 0.0054 0.0541 0.0561
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0054 0.0541 0.0561
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0054 0.0542 0.0562
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.0008 0.0015 0.0011
Brugia malayi ecdysteroid receptor 0.0011 0.0049 0.0047
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0278 0.315 0.3148
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0017 0.0119 0.2122
Trypanosoma brucei Silent information regulator 2 related protein 3 0.0016 0.011 0.011
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0054 0.0541 0.0567
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.059 0.0826
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0008 0.0004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0617 0.7085 0.7416
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0054 0.0541 0.0563
Leishmania major phosphatidylinositol 3-kinase, putative 0.0054 0.0541 0.0561
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.001 0.0006
Loa Loa (eye worm) hypothetical protein 0.0011 0.0043 0.0041
Trichomonas vaginalis PIKK family atypical protein kinase 0.066 0.7582 0.7937
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.1002 0.1049
Schistosoma mansoni serine/threonine protein kinase 0.0093 0.1002 0.1045
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0049 0.0047
Loa Loa (eye worm) hypothetical protein 0.0103 0.112 0.1169
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0049 0.0045
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0017 0.0119 0.2126
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.1002 0.1049
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0008 0.0004
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0008 0.0015 0.0011
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0008 0.0015 0.0011
Mycobacterium ulcerans NAD-dependent deacetylase 0.0016 0.011 0.0303
Onchocerca volvulus Bile acid receptor homolog 0.0011 0.0049 0.0436
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0017 0.0119 0.0119
Trichomonas vaginalis conserved hypothetical protein 0.0175 0.195 0.2041
Echinococcus granulosus GPCR family 2 0.003 0.0268 0.0276
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.053 0.9782
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0008 0.0015 0.0011
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0008 0.0015 0.0015
Toxoplasma gondii exonuclease III APE 0.0017 0.0119 0.0161
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0016 0.011 0.0116
Brugia malayi FAT domain containing protein 0.0121 0.1328 0.1387
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0054 0.0541 0.0567
Schistosoma mansoni hypothetical protein 0.0007 0.0005 0.0002
Echinococcus granulosus smad 0.0008 0.001 0.0006
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-33, BmFKBP-33 0.0007 0.0005 0.0002
Echinococcus multilocularis 0.0054 0.0541 0.0538
Schistosoma mansoni Smad4 0.0008 0.001 0.0006
Mycobacterium leprae conserved hypothetical protein 0.0054 0.0541 1
Trichomonas vaginalis GTP-binding protein (z) alpha subunit, gnaz, putative 0.0008 0.0015 0.0015
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0054 0.0541 0.0561
Trichomonas vaginalis PIKK family atypical protein kinase 0.066 0.7582 0.7937
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0065 0.0671 0.0698
Mycobacterium tuberculosis Conserved hypothetical protein 0.0054 0.0541 1
Schistosoma mansoni chromatin regulatory protein sir2 0.0016 0.011 0.0111
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0049 0.0047
Trichomonas vaginalis conserved hypothetical protein 0.0121 0.1328 0.1391
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0054 0.0541 0.0561
Loa Loa (eye worm) MH2 domain-containing protein 0.0114 0.1245 0.1299
Entamoeba histolytica G protein alpha subunit, putative 0.0008 0.0015 0.001
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0054 0.0541 0.0561
Trichomonas vaginalis PIKK family atypical protein kinase 0.0278 0.315 0.3298
Echinococcus granulosus FK506 binding protein 8 38 kDa 0.0007 0.0005 0.0002
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.053 0.9782
Loa Loa (eye worm) hypothetical protein 0.0046 0.0456 0.0474
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0111 0.1212 0.1264
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.019 0.2129 0.2225

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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