Detailed information for compound 16203

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 359.395 | Formula: C19H22FN3O3
  • H donors: 2 H acceptors: 3 LogP: 0.54 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1c(F)c(cc2c1c(=O)c(cn2C1CC1)C(=O)O)N1CCC(C1)N
  • InChi: 1S/C19H22FN3O3/c1-2-12-16-14(7-15(17(12)20)22-6-5-10(21)8-22)23(11-3-4-11)9-13(18(16)24)19(25)26/h7,9-11H,2-6,8,21H2,1H3,(H,25,26)
  • InChiKey: LKNVLXARJIDGMB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis G protein coupled receptor 139 0.0075 0.0168 0.0693
Echinococcus multilocularis allatostatin A receptor 0.0075 0.0168 0.0693
Trichomonas vaginalis CMGC family protein kinase 0.0107 0.0259 0.3141
Brugia malayi Phosphoglycerate kinase 0.0173 0.0452 0.2852
Echinococcus granulosus eukaryotic translation initiation factor 4E 0.0035 0.005 0.0142
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0054 0.1077
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0024 0.0017 0.0058
Schistosoma mansoni chromobox protein 0.0071 0.0154 0.0728
Toxoplasma gondii hypothetical protein 0.0051 0.0097 0.2021
Brugia malayi nuclear receptor NHR-88 0.0024 0.0017 0.0075
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0143 0.1591
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.0815 1
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0035 0.0636
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0075 0.0168 0.0693
Toxoplasma gondii phosphofructokinase domain-containing protein 0.003 0.0035 0.0636
Mycobacterium tuberculosis Conserved protein 0.0037 0.0054 0.005
Echinococcus granulosus microtubule associated protein 2 0.0723 0.2057 0.6462
Schistosoma mansoni lamin 0.0056 0.0111 0.0516
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0143 0.1591
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0075 0.0168 0.0512
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0825 0.2353 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0024 0.0017 0.005
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0107 0.0259 0.2936
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0075 0.0168 0.1037
Trypanosoma cruzi cysteine peptidase, putative 0.0067 0.0143 0.1591
Brugia malayi hypothetical protein 0.0043 0.0073 0.0432
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0006 0.0019
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0054 0.021
Echinococcus multilocularis fmrfamide receptor 0.0075 0.0168 0.0693
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0054 0.0612
Brugia malayi neuropeptide F receptor 0.0075 0.0168 0.1037
Treponema pallidum recombinase A 0.011 0.0268 0.2403
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0317 0.0871 1
Echinococcus granulosus tm gpcr rhodopsin 0.0075 0.0168 0.0512
Brugia malayi hypoxia-induced factor 1 0.0154 0.0398 0.2505
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0064 0.0133 0.1479
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.0815 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0075 0.0168 0.0793
Mycobacterium tuberculosis Conserved protein 0.0037 0.0054 0.005
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0027 0.0026 0.0091
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0173 0.0452 0.4102
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0095 0.0578
Brugia malayi ORL1-like opioid receptor 0.0075 0.0168 0.1037
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0075 0.0168 0.0793
Loa Loa (eye worm) 6-phosphofructokinase 0.0111 0.027 0.1715
Brugia malayi GnHR receptor homolog 0.0075 0.0168 0.1037
Loa Loa (eye worm) hypothetical protein 0.0075 0.0168 0.1065
Brugia malayi ThiF family protein 0.0049 0.0091 0.0546
Loa Loa (eye worm) hypothetical protein 0.0043 0.0073 0.0462
Leishmania major eukaryotic translation initiation factor-like protein 0.0035 0.005 0.052
Loa Loa (eye worm) hypothetical protein 0.0035 0.0049 0.0309
Echinococcus multilocularis hexokinase type 2 0.0081 0.0184 0.0762
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.0815 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0024 0.0017 0.005
Echinococcus multilocularis muscleblind protein 0.0152 0.0391 0.1643
Echinococcus granulosus serotonin receptor 0.0075 0.0168 0.0512
Echinococcus granulosus tachykinin peptides receptor 99D 0.0075 0.0168 0.0512
Toxoplasma gondii eukaryotic initiation factor-4E, putative 0.0035 0.005 0.0976
Brugia malayi sodium-independent organic anion transporter family protein 0.0043 0.0073 0.0432
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.0077 0.0838
Schistosoma mansoni amine GPCR 0.0075 0.0168 0.0793
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0024 0.0017 0.0058
Schistosoma mansoni single-minded 0.005 0.0093 0.043
Chlamydia trachomatis replicative DNA helicase 0.0393 0.1094 1
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0026 0.0025 0.0231
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0035 0.0369
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0006 0.0002
Brugia malayi photoreceptor-specific nuclear receptor 0.0024 0.0017 0.0075
Echinococcus granulosus 6 phosphofructokinase 0.0111 0.027 0.0835
Schistosoma mansoni opsin-like receptor 0.0075 0.0168 0.0793
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0061 0.0125 0.0377
Schistosoma mansoni alpha-1 adrenergic receptor 0.0075 0.0168 0.0793
Brugia malayi hexokinase 0.0081 0.0184 0.1141
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0075 0.0168 0.0793
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0075 0.0168 0.0693
Loa Loa (eye worm) hypothetical protein 0.0075 0.0168 0.1065
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0054 0.0106 0.1166
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0024 0.0017 0.0037
Entamoeba histolytica hexokinase 2 0.0081 0.0184 0.2211
Echinococcus granulosus single minded 2 0.0037 0.0055 0.0159
Onchocerca volvulus 0.0075 0.0168 0.9027
Echinococcus multilocularis ecdysone induced protein 78C 0.0024 0.0017 0.005
Leishmania major eukaryotic translation initiation factor eIF-4E, putative 0.0035 0.005 0.052
Trypanosoma cruzi cysteine peptidase, putative 0.0067 0.0143 0.1591
Loa Loa (eye worm) hypothetical protein 0.0037 0.0054 0.0346
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.0017 0.0037
Echinococcus granulosus lamin dm0 0.0056 0.0111 0.0333
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0054 0.0455
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.0815 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0075 0.0168 0.0693
Echinococcus multilocularis rhodopsin orphan GPCR 0.0075 0.0168 0.0693
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0173 0.0452 0.1216
Brugia malayi Cytochrome P450 family protein 0.0023 0.0015 0.0066
Loa Loa (eye worm) hypothetical protein 0.0024 0.0017 0.0106
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0024 0.0017 0.0075
Schistosoma mansoni amine GPCR 0.0075 0.0168 0.0793
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0143 0.1591
Loa Loa (eye worm) phosphofructokinase 0.0111 0.027 0.1715
Echinococcus multilocularis hexokinase 0.0081 0.0184 0.0762
Loa Loa (eye worm) hypothetical protein 0.0027 0.0026 0.0167
Loa Loa (eye worm) hypothetical protein 0.0075 0.0168 0.1065
Echinococcus granulosus rhodopsin orphan GPCR 0.0075 0.0168 0.0512
Echinococcus granulosus zinc finger protein 0.002 0.0006 0.0003
Schistosoma mansoni serine/threonine protein kinase 0.0107 0.0259 0.1239
Brugia malayi hypothetical protein 0.0075 0.0168 0.1037
Loa Loa (eye worm) hypothetical protein 0.0075 0.0168 0.1065
Schistosoma mansoni neuropeptide receptor 0.0075 0.0168 0.0793
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0107 0.0259 0.1646
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0024 0.0017 0.0106
Mycobacterium ulcerans phosphoglycerate kinase 0.0173 0.0452 0.411
Trichomonas vaginalis phosphofructokinase, putative 0.0111 0.027 0.3275
Brugia malayi steroid hormone receptor 0.0024 0.0017 0.0075
Leishmania major mitochondrial DNA polymerase beta 0.0317 0.0871 1
Trichomonas vaginalis phosphofructokinase, putative 0.0111 0.027 0.3275
Loa Loa (eye worm) hypothetical protein 0.0075 0.0168 0.1065
Echinococcus granulosus muscleblind protein 0.0152 0.0391 0.1215
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0014 0.003
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.015 0.0385 0.4385
Loa Loa (eye worm) hypothetical protein 0.0075 0.0168 0.1065
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0075 0.0168 0.0512
Echinococcus granulosus neuropeptide s receptor 0.0558 0.1574 0.4941
Loa Loa (eye worm) hypothetical protein 0.0075 0.0168 0.1065
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0035 0.005 0.0556
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0075 0.0168 0.0512
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0054 0.005
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0111 0.027 0.0265
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0024 0.0017 0.0075
Schistosoma mansoni opsin-like receptor 0.0075 0.0168 0.0793
Brugia malayi ecdysteroid receptor 0.0024 0.0017 0.0075
Loa Loa (eye worm) twinkle helicase 0.0112 0.0275 0.1748
Schistosoma mansoni RAR-like nuclear receptor 0.0024 0.0017 0.0058
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0024 0.0017 0.0037
Loa Loa (eye worm) neuropeptide F receptor 0.0075 0.0168 0.1065
Schistosoma mansoni hypothetical protein 0.0035 0.0049 0.0214
Echinococcus multilocularis mitogen activated protein kinase 0.0107 0.0259 0.1083
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0006 0.0017
Giardia lamblia Flap structure-specific endonuclease 0.0026 0.0025 0.0247
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0107 0.0259 0.2936
Loa Loa (eye worm) hypothetical protein 0.0075 0.0168 0.1065
Loa Loa (eye worm) hypothetical protein 0.0043 0.0073 0.0462
Echinococcus granulosus allatostatin A receptor 0.0075 0.0168 0.0512
Schistosoma mansoni ubiquitin-activating enzyme E1b 0.0032 0.0042 0.018
Onchocerca volvulus 0.0075 0.0168 0.9027
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0075 0.0168 0.0693
Loa Loa (eye worm) TYRA-2 protein 0.0075 0.0168 0.1065
Echinococcus multilocularis hexokinase 0.0081 0.0184 0.0762
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0024 0.0017 0.0075
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0075 0.0168 0.0793
Loa Loa (eye worm) hypothetical protein 0.004 0.0063 0.0403
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0558 0.1574 1
Entamoeba histolytica hexokinase 1 0.0081 0.0184 0.2211
Trypanosoma brucei ubiquitin-activating enzyme E1, putative 0.0032 0.0042 0.0425
Echinococcus granulosus SUMO activating enzyme subunit 1 0.0049 0.0091 0.027
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0024 0.0017 0.0075
Onchocerca volvulus 0.0043 0.0073 0.3349
Echinococcus multilocularis organic anion transporting polypeptide 30B 0.0043 0.0073 0.0289
Loa Loa (eye worm) hypothetical protein 0.0024 0.0017 0.0106
Entamoeba histolytica Flap nuclease, putative 0.0026 0.0025 0.0247
Loa Loa (eye worm) hexokinase 0.0025 0.0021 0.0132
Echinococcus granulosus organic anion transporting polypeptide 30B 0.0043 0.0073 0.0214
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0056 0.0111 0.0703
Echinococcus granulosus fmrfamide receptor 0.0075 0.0168 0.0512
Schistosoma mansoni microtubule-associated protein tau 0.0723 0.2057 1
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0145 0.0371 0.3363
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0143 0.1591
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0143 0.1591
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0054 0.0346
Schistosoma mansoni amine GPCR 0.0075 0.0168 0.0793
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0035 0.0369
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0024 0.0017 0.0075
Echinococcus granulosus rhodopsin orphan GPCR 0.0075 0.0168 0.0512
Brugia malayi G-protein coupled receptor 0.0075 0.0168 0.1037
Echinococcus multilocularis serotonin receptor 0.0075 0.0168 0.0693
Schistosoma mansoni biogenic amine receptor 0.0075 0.0168 0.0793
Loa Loa (eye worm) hypothetical protein 0.0043 0.0073 0.0462
Loa Loa (eye worm) hypothetical protein 0.0043 0.0073 0.0462
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.003 0.0035 0.0369
Echinococcus multilocularis rhodopsin orphan GPCR 0.0075 0.0168 0.0693
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0075 0.0168 0.0793
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0045 0.0077 0.0838
Brugia malayi Serotonin receptor 0.0075 0.0168 0.1037
Echinococcus multilocularis hexokinase 0.0081 0.0184 0.0762
Loa Loa (eye worm) hexokinase 0.0081 0.0184 0.1168
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0173 0.0452 0.5528
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0173 0.0452 1
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0054 0.0572
Echinococcus multilocularis rhodopsin orphan GPCR 0.0075 0.0168 0.0693
Onchocerca volvulus 0.0043 0.0073 0.3349
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0064 0.0133 0.1479
Echinococcus granulosus neuropeptide receptor 0.0075 0.0168 0.0512
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0024 0.0017 0.0106
Loa Loa (eye worm) hypothetical protein 0.0075 0.0168 0.1065
Echinococcus granulosus hexokinase 0.0081 0.0184 0.0564
Schistosoma mansoni neuropeptide F-like receptor 0.0075 0.0168 0.0793
Loa Loa (eye worm) hypothetical protein 0.0075 0.0168 0.1065
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0006 0.0019
Onchocerca volvulus 0.0075 0.0168 0.9027
Onchocerca volvulus 0.0075 0.0168 0.9027
Giardia lamblia Kinase, CMGC MAPK 0.0107 0.0259 0.3141
Giardia lamblia Fructose-bisphosphate aldolase 0.0297 0.0815 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0108 0.0684
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0054 0.005
Plasmodium falciparum phosphoglycerate kinase 0.0173 0.0452 1
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0075 0.0168 0.0793
Brugia malayi translation initiation factor 4E 0.0035 0.005 0.0287
Onchocerca volvulus Heterochromatin protein 1 homolog 0.004 0.0063 0.2797
Mycobacterium tuberculosis RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)]. 0.3163 0.9174 0.9173
Onchocerca volvulus 0.0037 0.0054 0.2256
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0075 0.0168 0.1065
Loa Loa (eye worm) hypothetical protein 0.0024 0.0017 0.0106
Loa Loa (eye worm) hypothetical protein 0.0075 0.0168 0.1065
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.003 0.0035 0.0369
Schistosoma mansoni hypothetical protein 0.0075 0.0168 0.0793
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.015 0.0385 0.4385
Schistosoma mansoni intermediate filament proteins 0.0056 0.0111 0.0516
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0006 0.0019
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0006 0.0017
Loa Loa (eye worm) hypothetical protein 0.0075 0.0168 0.1065
Treponema pallidum fructose-bisphosphate aldolase 0.0297 0.0815 0.7431
Leishmania major ubiquitin-activating enzyme-like protein 0.0032 0.0042 0.0425
Trypanosoma cruzi DNA repair protein, putative 0.0034 0.0046 0.0477
Plasmodium falciparum SUMO-activating enzyme subunit 1 0.0049 0.0091 0.1889
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0014 0.0047
Loa Loa (eye worm) hypothetical protein 0.0075 0.0168 0.1065
Echinococcus multilocularis neuropeptide s receptor 0.0558 0.1574 0.6683
Echinococcus multilocularis Solute carrier organic anion transporter family 0.0043 0.0073 0.0289
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0024 0.0017 0.0106
Echinococcus granulosus neuropeptide receptor 0.0075 0.0168 0.0512
Echinococcus granulosus rhodopsin orphan GPCR 0.0075 0.0168 0.0512
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0024 0.0017 0.0075
Echinococcus granulosus orexin receptor type 2 0.0075 0.0168 0.0512
Schistosoma mansoni biogenic amine (5HT) receptor 0.0075 0.0168 0.0793
Loa Loa (eye worm) hexokinase 0.0051 0.0096 0.0609
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0026 0.0025 0.0415
Brugia malayi MAP kinase sur-1 0.0107 0.0259 0.1621
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.0128 0.0811
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0075 0.0168 0.0693
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0054 0.005
Leishmania major hexokinase, putative 0.0081 0.0184 0.2067
Brugia malayi G-protein coupled receptor 0.0075 0.0168 0.1037
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0075 0.0168 0.1065
Echinococcus granulosus flap endonuclease 1 0.0026 0.0025 0.0063
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0075 0.0168 0.0512
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0005 0.0031
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0009 0.0056
Mycobacterium ulcerans hypothetical protein 0.0167 0.0434 0.394
Schistosoma mansoni phosphoglycerate kinase 0.0173 0.0452 0.2181
Brugia malayi Muscleblind-like protein 0.0152 0.0391 0.2459
Onchocerca volvulus 0.0043 0.0073 0.3349
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0075 0.0168 0.0512
Echinococcus granulosus mitogen activated protein kinase 3 0.0107 0.0259 0.0801
Onchocerca volvulus Neuropeptide F receptor homolog 0.0075 0.0168 0.9027
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0076 0.0171 0.1915
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.006 0.0122 0.0499
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0075 0.0168 0.0793
Loa Loa (eye worm) hypothetical protein 0.0075 0.0168 0.1065
Toxoplasma gondii hexokinase 0.0081 0.0184 0.3979
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0173 0.0452 0.5528
Mycobacterium ulcerans recombinase A 0.011 0.0268 0.2413
Brugia malayi hypothetical protein 0.0075 0.0168 0.1037
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0026 0.0025 0.0231
Toxoplasma gondii ABC1 family protein 0.0037 0.0054 0.1077
Trichomonas vaginalis CMGC family protein kinase 0.0107 0.0259 0.3141
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0031
Echinococcus multilocularis rhodopsin orphan GPCR 0.0075 0.0168 0.0693
Brugia malayi Melatonin receptor type 1A 0.0075 0.0168 0.1037
Loa Loa (eye worm) hypothetical protein 0.0051 0.0095 0.0607
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0173 0.0452 0.5168
Echinococcus multilocularis fmrfamide receptor 0.0075 0.0168 0.0693
Schistosoma mansoni neuropeptide receptor 0.0075 0.0168 0.0793
Onchocerca volvulus 0.0075 0.0168 0.9027
Onchocerca volvulus 0.0037 0.0055 0.2308
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0145 0.0371 0.0968
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0075 0.0168 0.0693
Trypanosoma brucei phosphoglycerate kinase, putative 0.0064 0.0133 0.1479
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0111 0.027 0.0659
Brugia malayi follicle stimulating hormone receptor 0.0558 0.1574 1
Wolbachia endosymbiont of Brugia malayi replicative DNA helicase 0.0393 0.1094 1
Onchocerca volvulus 0.0031 0.0038 0.13
Entamoeba histolytica phosphofructokinase, putative 0.0111 0.027 0.3275
Echinococcus granulosus somatostatin receptor 0.0075 0.0168 0.0512
Mycobacterium leprae PROBABLE REPLICATIVE DNA HELICASE DNAB replicative DNA helicase 0.0393 0.1094 0.3176
Loa Loa (eye worm) hypothetical protein 0.0075 0.0168 0.1065
Echinococcus granulosus g-protein coupled receptor 0.0075 0.0168 0.0512
Echinococcus multilocularis sex peptide receptor 0.0075 0.0168 0.0693
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0027 0.0026 0.0068
Loa Loa (eye worm) hypothetical protein 0.0043 0.0073 0.0462
Brugia malayi Dopamine receptor 0.0075 0.0168 0.1037
Loa Loa (eye worm) hypothetical protein 0.0072 0.0157 0.1
Brugia malayi cytoplasmic intermediate filament protein 0.003 0.0035 0.0192
Toxoplasma gondii phosphofructokinase PFKII 0.003 0.0035 0.0636
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0075 0.0168 0.0793
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0006 0.0019
Mycobacterium leprae Conserved hypothetical protein 0.1159 0.3327 1
Echinococcus multilocularis phosphoglycerate kinase 1 0.0173 0.0452 0.1906
Loa Loa (eye worm) hypothetical protein 0.0075 0.0168 0.1065
Plasmodium falciparum SUMO-activating enzyme subunit 2 0.0032 0.0042 0.0792
Schistosoma mansoni lamin 0.0056 0.0111 0.0516
Trichomonas vaginalis chromobox protein, putative 0.0071 0.0154 0.1845
Schistosoma mansoni eukaryotic translation initiation factor 4e 0.0035 0.005 0.022
Echinococcus multilocularis muscleblind protein 1 0.0152 0.0391 0.1643
Echinococcus granulosus peptide allatostatin:somatostatin 0.0075 0.0168 0.0512
Echinococcus granulosus biogenic amine 5HT receptor 0.0075 0.0168 0.0512
Loa Loa (eye worm) hypothetical protein 0.0075 0.0168 0.1065
Brugia malayi Dopamine receptor protein 2 0.0075 0.0168 0.1037
Brugia malayi nuclear hormone receptor 0.0024 0.0017 0.0075
Brugia malayi hypothetical protein 0.0075 0.0168 0.1037
Loa Loa (eye worm) hypothetical protein 0.0037 0.0054 0.0346
Loa Loa (eye worm) hypothetical protein 0.0075 0.0168 0.1065
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0111 0.027 0.3062
Brugia malayi Bromodomain containing protein 0.0039 0.0061 0.0359
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0107 0.0259 0.2936
Treponema pallidum phosphoglycerate kinase 0.0173 0.0452 0.4102
Echinococcus multilocularis neuropeptide receptor 0.0075 0.0168 0.0693
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0024 0.0017 0.0075
Schistosoma mansoni thyroid hormone receptor 0.0024 0.0017 0.0058
Schistosoma mansoni Replicative DNA helicase 0.0393 0.1094 0.5306
Trypanosoma brucei phosphoglycerate kinase 0.0064 0.0133 0.1479
Onchocerca volvulus Putative organic anion transporter 0.0043 0.0073 0.3349
Echinococcus multilocularis lamin dm0 0.0056 0.0111 0.0451
Echinococcus granulosus rhodopsin orphan GPCR 0.0075 0.0168 0.0512
Treponema pallidum replicative DNA helicase (dnaB) 0.0393 0.1094 1
Wolbachia endosymbiont of Brugia malayi recombinase A 0.011 0.0268 0.2403
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0024 0.0017 0.0037
Loa Loa (eye worm) hypothetical protein 0.0075 0.0168 0.1065
Echinococcus granulosus tm gpcr rhodopsin 0.0075 0.0168 0.0512
Echinococcus granulosus rhodopsin orphan GPCR 0.0075 0.0168 0.0512
Loa Loa (eye worm) hypothetical protein 0.0075 0.0168 0.1065
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0035 0.0636
Loa Loa (eye worm) hypothetical protein 0.0075 0.0168 0.1065
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0024 0.0017 0.0075
Loa Loa (eye worm) hypothetical protein 0.0075 0.0168 0.1065
Mycobacterium ulcerans hypothetical protein 0.0037 0.0054 0.0455
Schistosoma mansoni biogenic amine receptor 0.0075 0.0168 0.0793
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0075 0.0168 0.0693
Onchocerca volvulus Putative organic anion transporter 0.0043 0.0073 0.3349
Schistosoma mansoni adenoreceptor 0.0075 0.0168 0.0793
Onchocerca volvulus 0.0043 0.0073 0.3349
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0054 0.0211
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0075 0.0168 0.0793
Loa Loa (eye worm) hypothetical protein 0.0043 0.0074 0.0471
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0063 0.0724
Toxoplasma gondii 6-phosphofructokinase 0.003 0.0035 0.0636
Toxoplasma gondii transporter, major facilitator family protein 0.0043 0.0073 0.1487
Loa Loa (eye worm) hypothetical protein 0.0039 0.0061 0.039
Loa Loa (eye worm) hypothetical protein 0.0024 0.0017 0.0106
Echinococcus granulosus Solute carrier organic anion transporter family 0.0043 0.0073 0.0214
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0024 0.0017 0.0075
Echinococcus multilocularis g protein coupled receptor 0.0075 0.0168 0.0693
Brugia malayi hypothetical protein 0.0167 0.0436 0.2746
Schistosoma mansoni organic anion transporter 0.0043 0.0073 0.0331
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0054 0.0241
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0054 0.0612
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0006 0.0005
Loa Loa (eye worm) hypothetical protein 0.0075 0.0168 0.1065
Brugia malayi hexokinase type II 0.0026 0.0023 0.0114
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.0035 0.005 0.0556
Schistosoma mansoni myosin xvIII 0.0075 0.0168 0.0793
Loa Loa (eye worm) hypothetical protein 0.0037 0.0054 0.0346
Schistosoma mansoni phosphoglycerate kinase 0.0173 0.0452 0.2181
Brugia malayi hypothetical protein 0.0075 0.0168 0.1037
Echinococcus multilocularis chromobox protein 1 0.0071 0.0154 0.0636
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.0815 1
Schistosoma mansoni hypothetical protein 0.0054 0.0106 0.0491
Trypanosoma cruzi major cysteine proteinase, putative 0.0053 0.0101 0.1109
Loa Loa (eye worm) hypothetical protein 0.0075 0.0168 0.1065
Loa Loa (eye worm) translation initiation factor 4E 0.0035 0.005 0.0317
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0107 0.0259 0.2936
Entamoeba histolytica phosphofructokinase, putative 0.0111 0.027 0.3275
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0107 0.0259 0.5667
Echinococcus multilocularis zinc finger protein 0.002 0.0006 0.0004
Loa Loa (eye worm) 6-phosphofructokinase 0.0111 0.027 0.1715
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0064 0.0133 0.1479
Schistosoma mansoni nuclear hormone receptor 0.0024 0.0017 0.0058
Onchocerca volvulus 0.0075 0.0168 0.9027
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0006 0.0006
Onchocerca volvulus 0.0081 0.0184 1
Echinococcus granulosus sumo-activating enzyme subunit 2 0.0032 0.0042 0.0116
Echinococcus multilocularis transfer RNA-Lys 0.0037 0.0055 0.0215
Loa Loa (eye worm) hypothetical protein 0.0075 0.0168 0.1065
Brugia malayi PHD-finger family protein 0.0025 0.0021 0.0106
Echinococcus granulosus tm gpcr rhodopsin 0.0075 0.0168 0.0512
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0075 0.0168 0.0693
Schistosoma mansoni hypothetical protein 0.0075 0.0168 0.0793
Mycobacterium ulcerans beta-lactamase 0.0037 0.0054 0.0455
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0006 0.0014
Schistosoma mansoni sumo-1-activating enzyme E1a 0.0045 0.0077 0.0354
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0143 0.1591
Onchocerca volvulus 0.0043 0.0073 0.3349
Loa Loa (eye worm) hypothetical protein 0.0075 0.0168 0.1065
Loa Loa (eye worm) G-protein coupled receptor 0.0075 0.0168 0.1065
Echinococcus multilocularis rhodopsin orphan GPCR 0.0075 0.0168 0.0693
Trypanosoma brucei hexokinase, putative 0.0081 0.0184 0.2067
Echinococcus granulosus neuropeptide receptor A26 0.0558 0.1574 0.4941
Loa Loa (eye worm) hypothetical protein 0.0037 0.0054 0.0346
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0024 0.0017 0.0058
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0143 0.1591
Leishmania major phosphoglycerate kinase B, cytosolic 0.0173 0.0452 0.5168
Brugia malayi larval opioid receptor 0.0075 0.0168 0.1037
Loa Loa (eye worm) hypothetical protein 0.0041 0.0068 0.0435
Echinococcus multilocularis somatostatin receptor 0.0075 0.0168 0.0693
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0054 0.0156
Schistosoma mansoni steroid hormone receptor ad4bp 0.0024 0.0017 0.0058
Loa Loa (eye worm) hypothetical protein 0.0075 0.0168 0.1065
Echinococcus multilocularis neuropeptide FF receptor 2 0.0075 0.0168 0.0693
Echinococcus granulosus neuropeptides capa receptor 0.0075 0.0168 0.0512
Onchocerca volvulus 0.0081 0.0184 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0024 0.0017 0.0106
Loa Loa (eye worm) hypothetical protein 0.0075 0.0168 0.1065
Schistosoma mansoni neuropeptide f receptor 76f 0.0075 0.0168 0.0793
Toxoplasma gondii ThiF family protein 0.0032 0.0042 0.0792
Loa Loa (eye worm) hypothetical protein 0.0037 0.0054 0.0346
Echinococcus multilocularis G-protein coupled receptor, putative 0.0075 0.0168 0.0693
Chlamydia trachomatis recombinase RecA 0.011 0.0268 0.22
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0054 0.005
Loa Loa (eye worm) sodium-independent organic anion transporter 0.0043 0.0073 0.0462
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0054 0.0612
Echinococcus granulosus hexokinase 0.0081 0.0184 0.0564
Schistosoma mansoni biogenic amine (5HT) receptor 0.0075 0.0168 0.0793
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0061 0.0126 0.1396
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0035 0.0636
Onchocerca volvulus 0.0075 0.0168 0.9027
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0054 0.0572
Mycobacterium ulcerans replicative DNA helicase DnaB 0.0393 0.1094 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0167 0.0434 0.0429
Schistosoma mansoni bromodomain containing protein 0.0064 0.0135 0.0636
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0054 0.005
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0143 0.1591
Plasmodium vivax hexokinase, putative 0.0081 0.0184 0.3979
Onchocerca volvulus 0.0075 0.0168 0.9027
Echinococcus granulosus rhodopsin orphan GPCR 0.0075 0.0168 0.0512
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0024 0.0017 0.0037
Loa Loa (eye worm) hypothetical protein 0.0024 0.0017 0.0106
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.0017 0.005
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.0815 1
Echinococcus granulosus hypothetical protein 0.0075 0.0168 0.0512
Onchocerca volvulus 0.0081 0.0184 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0015 0.0097
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0095 0.0578
Echinococcus multilocularis FTZ F1 alpha 0.0024 0.0017 0.005
Loa Loa (eye worm) ThiF family protein 0.0032 0.0042 0.0265
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0145 0.0371 0.0366
Plasmodium falciparum hexokinase 0.0081 0.0184 0.3979
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0054 0.0612
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0143 0.1591
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0075 0.0168 0.0693
Trypanosoma brucei recA bacterial DNA recombination protein, putative 0.0034 0.0046 0.0477
Loa Loa (eye worm) hypothetical protein 0.0075 0.0168 0.1065
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0035 0.0369
Loa Loa (eye worm) hypoxia-induced factor 1 0.0154 0.0398 0.2528
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0075 0.0168 0.0793
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0024 0.0017 0.0037
Echinococcus granulosus rhodopsin orphan GPCR 0.0075 0.0168 0.0512
Loa Loa (eye worm) G-protein coupled receptor 0.0075 0.0168 0.1065
Schistosoma mansoni jumonji/arid domain-containing protein 0.0062 0.0128 0.0599
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0035 0.0369
Loa Loa (eye worm) hypothetical protein 0.0043 0.0073 0.0462
Echinococcus granulosus hexokinase type 2 0.0081 0.0184 0.0564
Brugia malayi Phosphoglycerate kinase 0.0064 0.0133 0.0816
Plasmodium vivax phosphoglycerate kinase, putative 0.0173 0.0452 1
Brugia malayi Serotonin receptor 0.0075 0.0168 0.1037
Giardia lamblia Phosphoglycerate kinase 0.0173 0.0452 0.5528
Echinococcus granulosus 7TM GPCR rhodopsin 0.0075 0.0168 0.0512
Trypanosoma brucei hexokinase 0.0081 0.0184 0.2067
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0006 0.001
Mycobacterium ulcerans lipase LipD 0.0037 0.0054 0.0455
Echinococcus granulosus neuropeptide Y receptor 0.0075 0.0168 0.0512
Loa Loa (eye worm) hypothetical protein 0.0173 0.0452 0.2874
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0075 0.0168 0.0693
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0061 0.0125 0.051
Loa Loa (eye worm) hypothetical protein 0.0075 0.0168 0.1065
Schistosoma mansoni growth hormone secretagogue receptor 0.0075 0.0168 0.0793
Schistosoma mansoni coup transcription factor 0.0024 0.0017 0.0058
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0075 0.0168 0.9027
Brugia malayi Dopamine receptor protein 1 0.0075 0.0168 0.1037
Loa Loa (eye worm) hypothetical protein 0.0075 0.0168 0.1065
Loa Loa (eye worm) intermediate filament protein 0.0056 0.0111 0.0703
Schistosoma mansoni 6-phosphofructokinase 0.0111 0.027 0.1292
Brugia malayi Tachykinin-like peptides receptor 99D 0.0075 0.0168 0.1037
Trichomonas vaginalis CMGC family protein kinase 0.0107 0.0259 0.3141
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0006 0.004
Onchocerca volvulus 0.0075 0.0168 0.9027
Echinococcus granulosus mitogen activated protein kinase 0.0107 0.0259 0.0801
Echinococcus multilocularis 6 phosphofructokinase 0.0111 0.027 0.1129
Chlamydia trachomatis phosphoglycerate kinase 0.0173 0.0452 0.3944
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0054 0.0572
Plasmodium vivax flap endonuclease 1, putative 0.0026 0.0025 0.0415
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.003 0.0306
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.015 0.0385 0.4385
Trypanosoma brucei protein kinase, putative 0.0107 0.0259 0.2936
Echinococcus multilocularis neuropeptides capa receptor 0.0075 0.0168 0.0693
Trypanosoma brucei phosphoglycerate kinase 0.0173 0.0452 0.5168
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.0815 1
Onchocerca volvulus 0.0075 0.0168 0.9027
Brugia malayi Intermediate filament tail domain containing protein 0.0056 0.0111 0.0675
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.0017 0.005
Plasmodium vivax SUMO-activating enzyme subunit 2, putative 0.0032 0.0042 0.0792
Echinococcus granulosus lysine specific demethylase 5A 0.0062 0.0128 0.0387
Loa Loa (eye worm) hypothetical protein 0.0075 0.0168 0.1065
Loa Loa (eye worm) melatonin receptor type 1A 0.0075 0.0168 0.1065
Brugia malayi sulfakinin receptor protein 0.0075 0.0168 0.1037
Trypanosoma cruzi hexokinase, putative 0.0081 0.0184 0.2067
Echinococcus granulosus G protein coupled receptor 139 0.0075 0.0168 0.0512
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0143 0.1591
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0024 0.0017 0.0058
Echinococcus multilocularis musashi 0.0056 0.0111 0.0451
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0075 0.0168 0.1037
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0054 0.005
Trichomonas vaginalis chromobox protein, putative 0.0071 0.0154 0.1845
Leishmania major cathepsin L-like protease 0.0067 0.0143 0.1591
Echinococcus multilocularis serotonin receptor 0.0075 0.0168 0.0693
Onchocerca volvulus 0.0075 0.0168 0.9027
Schistosoma mansoni amine GPCR 0.0075 0.0168 0.0793
Echinococcus granulosus g protein coupled receptor 0.0075 0.0168 0.0512
Plasmodium falciparum flap endonuclease 1 0.0026 0.0025 0.0415
Brugia malayi beta-lactamase family protein 0.0037 0.0054 0.0316
Echinococcus granulosus neuropeptide Y receptor 0.0075 0.0168 0.0512
Loa Loa (eye worm) hypothetical protein 0.0075 0.0168 0.1065
Loa Loa (eye worm) hypothetical protein 0.0049 0.0091 0.0576
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0024 0.0017 0.0058
Echinococcus multilocularis neuropeptide Y receptor 0.0075 0.0168 0.0693
Brugia malayi bHLH-PAS transcription factor 0.0037 0.0055 0.0321
Trypanosoma cruzi ubiquitin-activating enzyme, putative 0.0032 0.0042 0.0425
Loa Loa (eye worm) heterochromatin protein 1 0.0071 0.0154 0.098
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0075 0.0168 0.0793
Brugia malayi hypothetical protein 0.0075 0.0168 0.1037
Onchocerca volvulus 0.0075 0.0168 0.9027
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0075 0.0168 0.0793
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0075 0.0168 0.1065
Echinococcus granulosus sex peptide receptor 0.0075 0.0168 0.0512
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0054 0.0316
Loa Loa (eye worm) hypothetical protein 0.0075 0.0168 0.1065
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0107 0.0259 0.2936
Echinococcus multilocularis orexin receptor type 2 0.0075 0.0168 0.0693
Onchocerca volvulus 0.0037 0.0054 0.2256
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0054 0.005
Brugia malayi RE15519p 0.0075 0.0168 0.1037
Brugia malayi Heterochromatin protein 1 0.0071 0.0154 0.0952
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0297 0.0815 1
Brugia malayi Bromodomain containing protein 0.0076 0.017 0.1053
Loa Loa (eye worm) steroid hormone receptor 0.0024 0.0017 0.0106
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0024 0.0017 0.0075
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0076 0.0171 0.1915
Echinococcus multilocularis thyroid hormone receptor alpha 0.0024 0.0017 0.005
Onchocerca volvulus 0.0056 0.0111 0.5623
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0075 0.0168 0.0693
Brugia malayi beta-lactamase 0.0037 0.0054 0.0316
Trypanosoma cruzi cysteine peptidase, putative 0.0067 0.0143 0.1591
Trypanosoma cruzi hexokinase, putative 0.0081 0.0184 0.2067
Brugia malayi AKH receptor 0.0075 0.0168 0.1037
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0063 0.0724
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0035 0.005 0.0556
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0297 0.0815 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0023 0.0144
Schistosoma mansoni biogenic amine receptor 0.0075 0.0168 0.0793
Schistosoma mansoni 6-phosphofructokinase 0.0111 0.027 0.1292
Echinococcus multilocularis chromobox protein 1 0.0071 0.0154 0.0636
Loa Loa (eye worm) hypothetical protein 0.0024 0.0017 0.0106
Brugia malayi putative neuropeptide receptor 0.0075 0.0168 0.1037
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0075 0.0168 0.0793
Trichomonas vaginalis flap endonuclease-1, putative 0.0026 0.0025 0.0247
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0107 0.0259 0.2936
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.003 0.0035 0.0261
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-1 0.0035 0.005 0.052
Echinococcus granulosus chromobox protein 1 0.0071 0.0154 0.047
Echinococcus granulosus ecdysone induced protein 78C 0.0024 0.0017 0.0037
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0111 0.027 0.2425
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.0035 0.005 0.0556
Schistosoma mansoni neuropeptide F-like receptor 0.0075 0.0168 0.0793
Schistosoma mansoni ap endonuclease 0.002 0.0006 0.0007
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0075 0.0168 0.0793
Brugia malayi ThiF family protein 0.0032 0.0042 0.0235
Trypanosoma cruzi ubiquitin-activating enzyme, putative 0.0028 0.0029 0.0274
Echinococcus multilocularis g protein coupled receptor 0.0075 0.0168 0.0693
Loa Loa (eye worm) hypothetical protein 0.0075 0.0168 0.1065
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0075 0.0168 0.0693
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0024 0.0017 0.0075
Echinococcus granulosus dro:myosuppressin receptor 0.0075 0.0168 0.0512
Schistosoma mansoni hexokinase 0.0081 0.0184 0.0872
Schistosoma mansoni flap endonuclease-1 0.0024 0.0017 0.0061
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0035 0.0369
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0095 0.0607
Echinococcus granulosus g protein coupled receptor 0.0075 0.0168 0.0512
Loa Loa (eye worm) hypothetical protein 0.0075 0.0168 0.1065
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0054 0.0241
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0024 0.0017 0.0106
Echinococcus multilocularis neuropeptide Y receptor 0.0075 0.0168 0.0693
Brugia malayi Hexokinase family protein 0.0081 0.0184 0.1141
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0045 0.0077 0.0838
Mycobacterium ulcerans 6-phosphofructokinase 0.0111 0.027 0.2435
Echinococcus multilocularis neuropeptide receptor 0.0075 0.0168 0.0693
Leishmania major eukaryotic translation initiation factor-like 0.0035 0.005 0.052
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0024 0.0017 0.0075
Onchocerca volvulus 0.0037 0.0054 0.2256
Loa Loa (eye worm) beta-lactamase 0.0037 0.0054 0.0346
Schistosoma mansoni hypothetical protein 0.0075 0.0168 0.0793
Mycobacterium tuberculosis Conserved protein 0.0037 0.0054 0.005
Leishmania major hexokinase, putative 0.0081 0.0184 0.2067
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0075 0.0168 0.0793
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0173 0.0452 0.5168
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.0072 0.3323
Echinococcus multilocularis mitogen activated protein kinase 3 0.0107 0.0259 0.1083
Trichomonas vaginalis CMGC family protein kinase 0.0107 0.0259 0.3141
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0075 0.0168 0.1065
Brugia malayi hypothetical protein 0.0075 0.0168 0.1037
Loa Loa (eye worm) hypothetical protein 0.0075 0.0168 0.1065
Echinococcus granulosus hexokinase 0.0081 0.0184 0.0564
Schistosoma mansoni sumo-1-activating enzyme E1a 0.0049 0.0091 0.0418
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0111 0.027 0.3062
Loa Loa (eye worm) hypothetical protein 0.0031 0.0038 0.0244
Onchocerca volvulus Putative organic anion transporter 0.0043 0.0073 0.3349
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0075 0.0168 0.1037
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0024 0.0017 0.0106
Leishmania major phosphoglycerate kinase C, glycosomal 0.0173 0.0452 0.5168
Onchocerca volvulus 0.0075 0.0168 0.9027
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0035 0.0636
Leishmania major cathepsin L-like protease 0.0067 0.0143 0.1591
Brugia malayi putative neuropeptide receptor NPR1 0.0075 0.0168 0.1037
Trypanosoma cruzi DNA repair protein, putative 0.0034 0.0046 0.0477
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0075 0.0168 0.0793
Echinococcus multilocularis SUMO activating enzyme subunit 2 0.0032 0.0042 0.0157
Onchocerca volvulus 0.0075 0.0168 0.9027
Mycobacterium leprae RECA PROTEIN (RECOMBINASE A) [CONTAINS: Mle RECA INTEIN]. 0.011 0.0268 0.0652
Schistosoma mansoni zinc finger protein 0.002 0.0006 0.0004
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.0077 0.0838
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0054 0.0612
Echinococcus granulosus lamin 0.0056 0.0111 0.0333
Brugia malayi hypothetical protein 0.0075 0.0168 0.1037
Brugia malayi Steroid receptor seven-up type 2 0.0024 0.0017 0.0075
Entamoeba histolytica phosphofructokinase, putative 0.0111 0.027 0.3275
Onchocerca volvulus 0.0075 0.0168 0.9027
Schistosoma mansoni opsin-like receptor 0.0075 0.0168 0.0793
Brugia malayi neuropeptide F receptor 0.0075 0.0168 0.1037
Trichomonas vaginalis esterase, putative 0.0037 0.0054 0.0612
Onchocerca volvulus 0.0075 0.0168 0.9027
Loa Loa (eye worm) hypothetical protein 0.0026 0.0023 0.0148
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0143 0.1591
Echinococcus granulosus g protein coupled receptor 0.0075 0.0168 0.0512
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0075 0.0168 0.0793
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0317 0.0871 1
Brugia malayi intermediate filament protein 0.0056 0.0111 0.0675
Echinococcus multilocularis g protein coupled receptor 0.0075 0.0168 0.0693
Loa Loa (eye worm) hexokinase 0.0081 0.0184 0.1168
Echinococcus multilocularis lamin 0.0056 0.0111 0.0451
Loa Loa (eye worm) hypothetical protein 0.0152 0.0391 0.2482
Echinococcus granulosus alpha 1A adrenergic receptor 0.0075 0.0168 0.0512
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0024 0.0017 0.005
Echinococcus granulosus intermediate filament protein 0.0056 0.0111 0.0333
Loa Loa (eye worm) hypothetical protein 0.0055 0.0109 0.0691
Echinococcus granulosus biogenic amine 5HT receptor 0.0075 0.0168 0.0512
Loa Loa (eye worm) hypothetical protein 0.0056 0.0111 0.0703
Loa Loa (eye worm) hypothetical protein 0.0075 0.0168 0.1065
Loa Loa (eye worm) hypothetical protein 0.0037 0.0054 0.0346
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0024 0.0017 0.0058
Schistosoma mansoni retinoic acid receptor RXR 0.0024 0.0017 0.0058
Loa Loa (eye worm) hypothetical protein 0.0043 0.0073 0.0462
Schistosoma mansoni histamine h1 receptor 0.0075 0.0168 0.0793
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0072 0.0832
Schistosoma mansoni hypothetical protein 0.0075 0.0168 0.0793
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0075 0.0168 0.0793
Brugia malayi jmjC domain containing protein 0.0062 0.0128 0.0783
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0317 0.0871 1
Echinococcus multilocularis SUMO activating enzyme subunit 1 0.0049 0.0091 0.0365
Loa Loa (eye worm) hypothetical protein 0.0075 0.0168 0.1065
Echinococcus multilocularis neuropeptides capa receptor 0.0075 0.0168 0.0693
Echinococcus multilocularis g-protein coupled receptor 0.0075 0.0168 0.0693
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.003 0.0035 0.0222
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0075 0.0168 0.1037
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0054 0.0455
Loa Loa (eye worm) flap endonuclease-1 0.0026 0.0025 0.0158
Loa Loa (eye worm) hypothetical protein 0.0075 0.0168 0.1065
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0035 0.0369
Brugia malayi G protein-coupled receptor 0.0075 0.0168 0.1037
Schistosoma mansoni organic anion transporter 0.0043 0.0073 0.0331
Echinococcus granulosus 7tm_1 domain containing protein 0.0075 0.0168 0.0512
Leishmania major ATP-dependent phosphofructokinase 0.0111 0.027 0.3062
Schistosoma mansoni neuropeptide receptor 0.0075 0.0168 0.0793
Leishmania major cathepsin L-like protease 0.0067 0.0143 0.1591
Brugia malayi PAS domain containing protein 0.005 0.0093 0.0562
Trichomonas vaginalis 6-phosphofructokinase, putative 0.003 0.0035 0.0369
Schistosoma mansoni hypothetical protein 0.0021 0.0009 0.0019
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0006 0.0017
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0049 0.0279
Trypanosoma brucei Eukaryotic translation initiation factor 4E-1 0.0035 0.005 0.052
Echinococcus granulosus FTZ F1 alpha 0.0024 0.0017 0.0037
Echinococcus multilocularis dro:myosuppressin receptor 0.0075 0.0168 0.0693
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0075 0.0168 0.0793
Brugia malayi sodium-independent organic anion transporter family protein 0.0043 0.0073 0.0432
Loa Loa (eye worm) hypothetical protein 0.0075 0.0168 0.1065
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0014 0.0041
Echinococcus granulosus neuropeptide FF receptor 2 0.0075 0.0168 0.0512
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0072 0.0832
Brugia malayi 6-phosphofructokinase 0.0111 0.027 0.169
Trypanosoma cruzi MFS transporter, putative 0.0043 0.0073 0.0783
Brugia malayi sodium-independent organic anion transporter family protein 0.0043 0.0073 0.0432
Loa Loa (eye worm) neuropeptide F receptor 0.0075 0.0168 0.1065
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.003 0.0306
Echinococcus multilocularis microtubule associated protein 2 0.0723 0.2057 0.8741
Brugia malayi hypothetical protein 0.0075 0.0168 0.1037
Echinococcus multilocularis flap endonuclease 1 0.0026 0.0025 0.0085
Brugia malayi Flap endonuclease-1 0.0026 0.0025 0.0127
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0035 0.005 0.0556
Echinococcus multilocularis rhodopsin orphan GPCR 0.0075 0.0168 0.0693
Schistosoma mansoni neuropeptide receptor 0.0075 0.0168 0.0793
Loa Loa (eye worm) hypothetical protein 0.0152 0.0391 0.2482
Brugia malayi hypothetical protein 0.0075 0.0168 0.1037
Schistosoma mansoni aryl hydrocarbon receptor 0.005 0.0093 0.043
Loa Loa (eye worm) hypothetical protein 0.0026 0.0023 0.0148
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0026 0.0025 0.0231
Mycobacterium ulcerans putative regulatory protein 0.0037 0.0055 0.0463
Onchocerca volvulus Hexokinase homolog 0.0051 0.0096 0.4734
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0173 0.0452 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0024 0.0017 0.005
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0076 0.0171 0.1915
Brugia malayi prostaglandin transporter 0.0043 0.0073 0.0432
Trypanosoma cruzi cruzipain precursor, putative 0.0067 0.0143 0.1591
Brugia malayi Hexokinase family protein 0.0025 0.0021 0.0101
Treponema pallidum hexokinase (hxk) 0.0081 0.0184 0.1632
Loa Loa (eye worm) hypothetical protein 0.0024 0.0017 0.0106
Trichomonas vaginalis phosphofructokinase, putative 0.0111 0.027 0.3275
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-1 0.0035 0.005 0.052
Loa Loa (eye worm) hexokinase type II 0.0081 0.0184 0.1168
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0075 0.0168 0.0693
Brugia malayi Hexokinase family protein 0.0051 0.0096 0.058
Loa Loa (eye worm) hypothetical protein 0.0026 0.0023 0.0144
Echinococcus granulosus phosphoglycerate kinase 1 0.0173 0.0452 0.1409
Entamoeba histolytica phosphoglycerate kinase, putative 0.0173 0.0452 0.5528
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0075 0.0168 0.0793
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0075 0.0168 0.0793
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0024 0.0017 0.0075
Echinococcus multilocularis eukaryotic translation initiation factor 4E 0.0035 0.005 0.0192
Schistosoma mansoni thyroid hormone receptor 0.0024 0.0017 0.0058
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0107 0.0259 0.2936
Trypanosoma brucei phosphoglycerate kinase 0.0173 0.0452 0.5168
Loa Loa (eye worm) hypothetical protein 0.0075 0.0168 0.1065
Echinococcus granulosus Solute carrier family 22 5 0.1108 0.3181 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.0815 1
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0035 0.005 0.0556
Loa Loa (eye worm) hypothetical protein 0.0024 0.0017 0.0106
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0075 0.0168 0.0512
Brugia malayi hypothetical protein 0.0075 0.0168 0.1037
Echinococcus granulosus neuropeptides capa receptor 0.0075 0.0168 0.0512
Onchocerca volvulus 0.0075 0.0168 0.9027
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0234 0.063 0.0625
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0173 0.0452 0.0448
Echinococcus multilocularis rhodopsin orphan GPCR 0.0075 0.0168 0.0693
Trichomonas vaginalis phosphofructokinase, putative 0.0111 0.027 0.3275
Brugia malayi beta-lactamase family protein 0.0037 0.0054 0.0316
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0075 0.0168 0.0693
Schistosoma mansoni ap endonuclease 0.002 0.0006 0.0007
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0075 0.0168 0.0693
Loa Loa (eye worm) hypothetical protein 0.0075 0.0168 0.1065
Loa Loa (eye worm) hypothetical protein 0.0075 0.0168 0.1065
Leishmania major hypothetical protein, conserved 0.0037 0.0054 0.0572
Onchocerca volvulus 0.0056 0.0111 0.5623
Plasmodium vivax ubiquitin activating enzyme, putative 0.0049 0.0091 0.1889
Echinococcus multilocularis lysine specific demethylase 5A 0.006 0.0122 0.0499
Brugia malayi chromobox protein homolog 3 0.004 0.0063 0.0373
Brugia malayi hypothetical protein 0.0043 0.0073 0.0432
Schistosoma mansoni chromobox protein 0.0071 0.0154 0.0728
Brugia malayi phosphofructokinase 0.0111 0.027 0.169
Schistosoma mansoni jumonji/arid domain-containing protein 0.0062 0.0128 0.0599
Loa Loa (eye worm) hypothetical protein 0.0075 0.0168 0.1065
Schistosoma mansoni jumonji domain containing protein 0.006 0.0122 0.0571
Brugia malayi G protein-coupled receptor F59B2.13 0.0075 0.0168 0.1037
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0006 0.0017
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.006 0.0122 0.0369
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.0017 0.0037
Brugia malayi 6-phosphofructokinase 0.0111 0.027 0.169
Schistosoma mansoni amine GPCR 0.0075 0.0168 0.0793
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0075 0.0168 0.0793
Brugia malayi jmjC domain containing protein 0.006 0.0122 0.0747
Echinococcus granulosus chromobox protein 1 0.0071 0.0154 0.047
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0075 0.0168 0.1037
Echinococcus multilocularis neuropeptide receptor A26 0.0558 0.1574 0.6683
Loa Loa (eye worm) hypothetical protein 0.0167 0.0436 0.2768
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0024 0.0017 0.0106
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0054 0.0155
Toxoplasma gondii hypothetical protein 0.0049 0.0091 0.1889
Brugia malayi Nuclear hormone receptor-like 1 0.0024 0.0017 0.0075
Trypanosoma brucei hexokinase 0.0081 0.0184 0.2067
Onchocerca volvulus 0.0051 0.0096 0.4734

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 46 ug ml-1 Mammalian cell cytotoxicity test in chinese hamster V79 cells (clonogenic cytotoxicity) ChEMBL. 1469702
MIC (functional) = 0.4 ug ml-1 Antibacterial activity was determined against gram negative organism, E. coli(vogel) ChEMBL. 2002456
MIC (functional) = 0.4 ug ml-1 Antibacterial activity was determined against gram negative organism, E. coli(vogel) ChEMBL. 2002456
MIC (functional) = 0.8 ug ml-1 Antibacterial activity against gram negative organism, Escherichia cloacae (MA2646) ChEMBL. 2002456
MIC (functional) = 1.6 ug ml-1 Antibacterial activity was determined against gram negative organism, K. pneumonia(MGH-2) ChEMBL. 2002456
MIC (functional) = 1.6 ug ml-1 Antibacterial activity was determined against gram positive organism, S. pneumoniae (SV-1) ChEMBL. 2002456
MIC (functional) = 1.81 ug ml-1 Antibacterial activity against five Gram-negative bacteria ChEMBL. 1469702
MIC (functional) > 2.71 ug ml-1 Antibacterial activity against five Gram-positive bacteria targeting topoisomerase II (DNA gyrase B GyrB) ChEMBL. 1469702
MIC (functional) > 2.71 ug ml-1 Antibacterial activity against five Gram-positive bacteria targeting topoisomerase II (DNA gyrase B GyrB) ChEMBL. 1469702
MIC (functional) = 3.1 ug ml-1 Antibacterial activity was determined against gram positive organism, S. aureus (UC76) ChEMBL. 2002456
MIC (functional) = 3.1 ug ml-1 Antibacterial activity was determined against gram positive organism, S. pyogenes (C203) ChEMBL. 2002456
MIC (functional) = 6.3 ug ml-1 Antibacterial activity was determined against gram negative organism, P. rettgeri. (M1771) ChEMBL. 2002456
MIC (functional) = 12.5 ug ml-1 Antibacterial activity was determined against gram negative organism, P. aeruginosa (UI-18) ChEMBL. 2002456
MIC (functional) = 12.5 ug ml-1 Antibacterial activity was determined against gram positive organism, S. aureus (H228) ChEMBL. 2002456
MIC (functional) = 25 ug ml-1 Antibacterial activity was determined against gram positive organism, S. faecalis (MGH-2) ChEMBL. 2002456
Ratio (functional) = 2.09 MIC ratio measured as the mean MICs of gram-negative bacteria ChEMBL. 2002456
Ratio (functional) = 5.45 MIC ratio measured as the mean MICs of gram-positive bacteria ChEMBL. 2002456

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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