Detailed information for compound 1623221

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 350.823 | Formula: C15H15ClN4O2S
  • H donors: 4 H acceptors: 3 LogP: 1.88 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCc1cnc(c(c1/C=N/NC(=S)Nc1cccc(c1)Cl)O)C
  • InChi: 1S/C15H15ClN4O2S/c1-9-14(22)13(10(8-21)6-17-9)7-18-20-15(23)19-12-4-2-3-11(16)5-12/h2-7,21-22H,8H2,1H3,(H2,19,20,23)/b18-7+
  • InChiKey: YFJGFVLHZQRZCR-CNHKJKLMSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens chromobox homolog 1 Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed) iota Starlite/ChEMBL No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Homo sapiens bromodomain adjacent to zinc finger domain, 2B Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references
Homo sapiens l(3)mbt-like 1 (Drosophila) Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens tyrosyl-DNA phosphodiesterase 1 Starlite/ChEMBL No references
Homo sapiens huntingtin Starlite/ChEMBL No references
Homo sapiens RAB9A, member RAS oncogene family Starlite/ChEMBL No references
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Schistosoma japonicum hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma japonicum ko:K01549 ATP synthase [EC3.6.3.14], putative Get druggable targets OG5_131570 All targets in OG5_131570
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Echinococcus granulosus bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni hypothetical protein Get druggable targets OG5_130415 All targets in OG5_130415
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus granulosus endonuclease exonuclease phosphatase Get druggable targets OG5_130415 All targets in OG5_130415
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum Lethal(3)malignant brain tumor-like 4 protein, putative Get druggable targets OG5_130415 All targets in OG5_130415
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Brugia malayi Heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Brugia malayi Bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Brugia malayi hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania infantum tyrosyl-DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis endonuclease exonuclease phosphatase Get druggable targets OG5_130415 All targets in OG5_130415
Onchocerca volvulus Heterochromatin protein 1 homolog Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Echinococcus multilocularis bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus multilocularis transcription factor Dp 1 Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus granulosus transcription factor Dp 1 Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania donovani tyrosyl-DNA phosphodiesterase-like protein Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania braziliensis tyrosyl-DNA phosphodiesterase, putative;with=GeneDB:LinJ33_V3.3210 Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Trypanosoma congolense tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Leishmania mexicana tyrosyl-DNA phosphodiesterase-like protein Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma mansoni tyrosyl-DNA phosphodiesterase Get druggable targets OG5_129037 All targets in OG5_129037
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_129037 All targets in OG5_129037
Theileria parva hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Onchocerca volvulus Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma japonicum Conserved hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Schistosoma japonicum ko:K01113 phosphodiesterase/alkaline phosphatase D [EC3.1.4.1], putative Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma brucei gambiense tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma japonicum Cleft lip and palate transmembrane protein 1-like protein, putative Get druggable targets OG5_131570 All targets in OG5_131570
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Schistosoma japonicum expressed protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Chromobox protein homolog 5, putative Get druggable targets OG5_129545 All targets in OG5_129545
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Leishmania major tyrosyl-DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Loa Loa (eye worm) heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma mansoni bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Cryptosporidium parvum tyrosyl-DNA phodphodiesterase 1 (tdp1) Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma japonicum Lethal(3)malignant brain tumor-like 3 protein, putative Get druggable targets OG5_130415 All targets in OG5_130415
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative Get druggable targets OG5_129037 All targets in OG5_129037
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Plasmodium falciparum ras-related protein Rab-5B RAB9A, member RAS oncogene family 201 aa 165 aa 30.9 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) heterochromatin protein 1 0.0084 0.0745 0.3003
Loa Loa (eye worm) helicase 0.0014 0.0018 0.0071
Echinococcus granulosus dnaJ subfamily B 0.0494 0.4982 0.5867
Loa Loa (eye worm) hypothetical protein 0.0046 0.0354 0.1428
Echinococcus multilocularis cpg binding protein 0.0039 0.0278 0.0278
Mycobacterium leprae Probable lipase LipE 0.0043 0.0325 0.5
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.008 0.07 0.0824
Mycobacterium tuberculosis Conserved protein 0.0043 0.0325 0.0793
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0002 0.0002
Trypanosoma brucei DNA polymerase eta, putative 0.0023 0.0116 0.1136
Echinococcus multilocularis polycomb protein SCMH1 0.0058 0.0471 0.0471
Loa Loa (eye worm) hypothetical protein 0.0043 0.0325 0.1309
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0116 0.0789
Loa Loa (eye worm) hypothetical protein 0.0014 0.0018 0.0071
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0002 0.0006
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0075 0.065 0.0763
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0006
Echinococcus granulosus chromobox protein 2 0.0014 0.0018 0.0021
Brugia malayi Protein cec-1. 0.0014 0.0018 0.0065
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0002 0.0002
Schistosoma mansoni chromobox protein 0.0014 0.0018 0.0019
Echinococcus multilocularis Chromobox protein 3 0.0014 0.0018 0.0018
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0116 0.0789
Brugia malayi F/Y-rich N-terminus family protein 0.0014 0.0022 0.0084
Schistosoma mansoni DNA polymerase eta 0.0023 0.0116 0.0135
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0325 0.1088
Loa Loa (eye worm) hypothetical protein 0.0037 0.0258 0.1038
Brugia malayi PHD-finger family protein 0.0032 0.0207 0.0828
Brugia malayi beta-lactamase family protein 0.0043 0.0325 0.1304
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0006
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0014 0.0018 0.0019
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0116 0.0789
Trypanosoma cruzi DNA polymerase eta, putative 0.0023 0.0116 0.0789
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.0116 0.0789
Schistosoma mansoni zinc finger protein 0.0026 0.014 0.0163
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0325 0.1088
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0022 0.0099 0.0288
Onchocerca volvulus 0.0043 0.0325 0.1139
Echinococcus granulosus polycomb protein SCMH1 0.0058 0.0471 0.0555
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0252 0.2482 1
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0325 0.5
Loa Loa (eye worm) hypothetical protein 0.0043 0.0325 0.1309
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0633 1
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.008 0.07 0.2819
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0325 0.0793
Loa Loa (eye worm) hypothetical protein 0.0014 0.0018 0.0071
Loa Loa (eye worm) hypothetical protein 0.0085 0.0758 0.3056
Onchocerca volvulus 0.0014 0.0018 0.0057
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.2747 1
Trichomonas vaginalis chromobox protein, putative 0.0051 0.04 0.1354
Echinococcus multilocularis dna polymerase eta 0.0023 0.0116 0.0116
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0014 0.0018 0.0018
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0325 0.0383
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0002 0.0006
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.1366 0.5504
Brugia malayi beta-lactamase 0.0043 0.0325 0.1304
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0325 0.0381
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0066 0.0553 0.0553
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.0116 0.0349
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0057 0.0469 0.055
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0116 0.1136
Mycobacterium tuberculosis Conserved protein 0.0043 0.0325 0.0793
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0227 0.2222 0.2617
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0116 0.0135
Brugia malayi Bromodomain containing protein 0.0093 0.0832 0.3349
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0325 0.1304
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0002 0.0002
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0116 0.0463
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0022 0.0099 0.0288
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.4982 0.4982
Loa Loa (eye worm) hypothetical protein 0.0014 0.0018 0.0071
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.8491 0.8491
Brugia malayi beta-lactamase family protein 0.0043 0.0325 0.1304
Onchocerca volvulus Huntingtin homolog 0.0148 0.1405 0.4943
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0325 0.4083
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0325 0.1088
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0116 0.1136
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0002 0.0002
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.07 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0363 0.1463
Echinococcus granulosus chromobox protein 1 0.0084 0.0745 0.0878
Schistosoma mansoni chromobox protein 0.0014 0.0018 0.0019
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.008 0.07 0.2814
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0116 0.1136
Loa Loa (eye worm) hypothetical protein 0.0066 0.0553 0.223
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0116 0.0469
Schistosoma mansoni bromodomain containing protein 0.0078 0.0686 0.0806
Onchocerca volvulus 0.0014 0.0018 0.0057
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0051 0.0398 0.0467
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0002 0.0002
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0325 0.1088
Schistosoma mansoni cpg binding protein 0.0039 0.0278 0.0326
Loa Loa (eye worm) hypothetical protein 0.0053 0.0428 0.1726
Loa Loa (eye worm) hypothetical protein 0.0014 0.0018 0.0071
Echinococcus granulosus histone lysine methyltransferase setb 0.0057 0.0469 0.0552
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0002 0.0002
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0043 0.0324 0.0382
Brugia malayi Pre-SET motif family protein 0.0037 0.0256 0.1026
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0006
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.07 1
Schistosoma mansoni hypothetical protein 0.0014 0.0018 0.0019
Schistosoma mansoni cpg binding protein 0.0035 0.0234 0.0274
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0256 0.03
Trichomonas vaginalis esterase, putative 0.0043 0.0325 0.1088
Echinococcus multilocularis chromobox protein 1 0.0084 0.0745 0.0745
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0006
Echinococcus granulosus dna polymerase kappa 0.0023 0.0116 0.0137
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0018 0.0062 0.0071
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0006
Loa Loa (eye worm) CHromoDomain protein family member 0.0018 0.0062 0.025
Trichomonas vaginalis chromobox protein, putative 0.0084 0.0745 0.2577
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0047 0.0363 0.1273
Plasmodium vivax SET domain protein, putative 0.0037 0.0256 0.7754
Loa Loa (eye worm) hypothetical protein 0.0043 0.0325 0.1309
Leishmania major DNA polymerase kappa, putative 0.0023 0.0116 0.0789
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0002 0.0006
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.0633 0.8957
Loa Loa (eye worm) hypothetical protein 0.0148 0.1405 0.5661
Echinococcus multilocularis dna polymerase kappa 0.0023 0.0116 0.0116
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0325 0.0793
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0002 0.0002
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0116 0.1136
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.0116 0.0137
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.0116 0.1446
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0037 0.0256 0.0256
Brugia malayi M-phase phosphoprotein, mpp8 0.0014 0.0018 0.0065
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0058 0.0471 0.0553
Echinococcus granulosus chromobox protein 1 0.0084 0.0745 0.0878
Brugia malayi hypothetical protein 0.0014 0.0018 0.0065
Trichomonas vaginalis chromobox protein, putative 0.0051 0.04 0.1354
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.0633 0.1302
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0021 0.0088 0.0088
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0029 0.0177 0.0207
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0002 0.0002
Brugia malayi MH2 domain containing protein 0.0144 0.1366 0.5501
Loa Loa (eye worm) MBCTL1 0.0066 0.0553 0.223
Echinococcus multilocularis chromobox protein 2 0.0014 0.0018 0.0018
Toxoplasma gondii ABC1 family protein 0.0043 0.0325 0.0649
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0002 0.0002
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0325 0.0793
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0088 0.0102
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.0096 0.0387
Echinococcus granulosus fetal alzheimer antigen falz 0.0029 0.0177 0.0209
Toxoplasma gondii 1,3-beta-glucan synthase component protein 0.0471 0.4748 1
Mycobacterium ulcerans hypothetical protein 0.0043 0.0325 0.4033
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0325 0.4083
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.0633 0.0746
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0002 0.0002
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0037 0.0256 0.0504
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0002 0.0002
Echinococcus multilocularis transcription factor Dp 1 0.0046 0.0352 0.0352
Schistosoma mansoni hypothetical protein 0.035 0.3496 0.4116
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0325 0.4033
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0002 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0221 0.0719
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0116 0.0789
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0018 0.0062 0.0073
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0022 0.0099 0.0288
Loa Loa (eye worm) PHD-finger family protein 0.0025 0.0133 0.0536
Onchocerca volvulus 0.0287 0.2841 1
Brugia malayi CHD4 protein 0.0018 0.0062 0.0244
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0633 0.0744
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0116 0.1136
Echinococcus granulosus methyl CpG binding domain protein 2 0.0021 0.0088 0.0104
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.0116 0.0349
Onchocerca volvulus Huntingtin homolog 0.0148 0.1405 0.4943
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0066 0.0553 0.2225
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0002 0.0002
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0018 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0014 0.0018 0.0071
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0325 0.4033
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0633 1
Brugia malayi CXXC zinc finger family protein 0.0035 0.0234 0.0937
Loa Loa (eye worm) hypothetical protein 0.0058 0.0471 0.1898
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0055 0.0133
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0058 0.0471 0.1653
Brugia malayi chromobox protein homolog 3 0.0047 0.0363 0.1457
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0116 0.1136
Brugia malayi Heterochromatin protein 1 0.0084 0.0745 0.2999
Mycobacterium ulcerans beta-lactamase 0.0043 0.0325 0.4033
Brugia malayi mbt repeat family protein 0.0058 0.0471 0.1893
Loa Loa (eye worm) hypothetical protein 0.0043 0.0325 0.1309
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0002 0.0006
Schistosoma mansoni hypothetical protein 0.0494 0.4982 0.5867
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.0633 0.1966
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0074 0.0641 0.0755
Echinococcus granulosus Chromobox protein 3 0.0014 0.0018 0.0021
Echinococcus granulosus zinc finger protein 0.0026 0.014 0.0165
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0006
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0057 0.0469 0.0469
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0116 0.1136
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.1366 0.5504
Brugia malayi Pre-SET motif family protein 0.0252 0.2482 1
Onchocerca volvulus 0.0051 0.0398 0.1397
Onchocerca volvulus 0.0035 0.0234 0.0819
Schistosoma mansoni hypothetical protein 0.0018 0.0066 0.0076
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0002 0.0002
Leishmania major hypothetical protein, conserved 0.0043 0.0325 0.4083
Echinococcus multilocularis zinc finger protein 0.0026 0.014 0.014
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0022 0.0099 0.0288
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.0471 0.0553
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0061 0.0154
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0006
Echinococcus granulosus SAM and MBT domain containing protein 0.0058 0.0471 0.0555
Echinococcus granulosus dna polymerase eta 0.0023 0.0116 0.0137
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0325 0.0793
Loa Loa (eye worm) hypothetical protein 0.0014 0.0018 0.0071
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0325 0.0793
Schistosoma mansoni cpg binding protein 0.0039 0.0278 0.0326
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0014 0.0018 0.0021
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0002 0.0006
Onchocerca volvulus 0.0043 0.0325 0.1139
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0116 0.1136
Schistosoma mansoni myelin transcription factor 1 myt1 0.0066 0.0553 0.065
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0325 0.4306
Echinococcus granulosus cpg binding protein 0.0039 0.0278 0.0328
Loa Loa (eye worm) hypothetical protein 0.0148 0.1405 0.5661
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0014 0.0018 0.5
Trichomonas vaginalis set domain proteins, putative 0.0287 0.2841 1
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.008 0.07 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0002 0.0006
Trichomonas vaginalis chromobox protein, putative 0.0084 0.0745 0.2577
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0325 0.0325
Loa Loa (eye worm) hypothetical protein 0.0023 0.0116 0.0469
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0074 0.0641 0.0641
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0363 0.1223
Brugia malayi Associated with TFs and helicases family protein 0.0014 0.0018 0.0065
Toxoplasma gondii histone lysine methyltransferase SET1 0.007 0.0598 0.1227
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0221 0.0719
Trypanosoma brucei ISWI complex protein 0.0018 0.0066 0.0378
Loa Loa (eye worm) hypothetical protein 0.0057 0.0469 0.1889
Schistosoma mansoni hypothetical protein 0.0025 0.0133 0.0155
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0029 0.0177 0.0177
Schistosoma mansoni zinc finger protein 0.0018 0.0066 0.0076
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0002 0.0002
Echinococcus granulosus microtubule associated protein 2 0.0833 0.8491 1
Loa Loa (eye worm) mbt repeat family protein 0.0058 0.0471 0.1898
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0057 0.0469 0.055
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.8491 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0022 0.0099 0.0288
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0014 0.0018 0.0065
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0325 0.1309
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0234 0.0943
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0325 0.0381
Loa Loa (eye worm) hypothetical protein 0.0014 0.0018 0.0071
Brugia malayi SET domain containing protein 0.0016 0.0039 0.0152
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0002 0.0006
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0043 0.0324 0.0324
Loa Loa (eye worm) hypothetical protein 0.0043 0.0325 0.1309
Mycobacterium tuberculosis Conserved protein 0.0043 0.0325 0.0793
Brugia malayi hypothetical protein 0.0148 0.1405 0.5659
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0116 0.1136
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0325 1
Mycobacterium ulcerans lipase LipD 0.0043 0.0325 0.4033
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0022 0.0099 0.0288
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0633 1
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.0471 0.0553
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0116 0.1136
Schistosoma mansoni chromobox protein 0.0084 0.0745 0.0876
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0002 0.0002
Echinococcus multilocularis Chromo domain 0.0014 0.0018 0.0018
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0066 0.0553 0.0652
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0002 0.0002
Echinococcus granulosus Chromo domain 0.0014 0.0018 0.0021
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0002 0.0002
Echinococcus multilocularis chromobox protein 1 0.0084 0.0745 0.0745
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0116 0.0135
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.0116 0.0116
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0014 0.0018 0.0019
Trypanosoma brucei unspecified product 0.0023 0.0116 0.1136
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0002 0.0006
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0325 0.1088
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0325 0.0793
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0088 0.0102
Echinococcus multilocularis SAM and MBT domain containing protein 0.0058 0.0471 0.0471
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0061 0.0154
Brugia malayi Bromodomain containing protein 0.0046 0.0354 0.1419
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0363 0.1223
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.008 0.07 1
Onchocerca volvulus 0.0058 0.0471 0.1653
Echinococcus granulosus transcription factor Dp 1 0.0046 0.0352 0.0415
Brugia malayi mbt repeat family protein 0.0058 0.0471 0.1893
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0014 0.0018 0.0019
Echinococcus multilocularis histone acetyltransferase MYST2 0.0066 0.0553 0.0553
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0116 0.1136
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0051 0.04 0.1403
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0116 0.1136
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0633 0.0744
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0116 0.0463
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.008 0.07 0.0822
Brugia malayi Valyl-tRNA synthetase 0.0014 0.0018 0.0065
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.008 0.07 0.07
Plasmodium falciparum heterochromatin protein 1 0.0014 0.0018 0.5
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0022 0.0099 0.0288
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0022 0.0099 0.0288
Onchocerca volvulus 0.0037 0.0258 0.0902
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0234 0.0276
Loa Loa (eye worm) hypothetical protein 0.0049 0.0384 0.1547
Echinococcus granulosus histone acetyltransferase MYST2 0.0066 0.0553 0.0652
Onchocerca volvulus 0.0043 0.0325 0.1139
Schistosoma mansoni chromobox protein 0.0084 0.0745 0.0876
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0227 0.2222 0.2222
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.0633 0.0633
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0006
Loa Loa (eye worm) hypothetical protein 0.0043 0.0325 0.1309
Loa Loa (eye worm) beta-lactamase 0.0043 0.0325 0.1309
Leishmania major DNA polymerase eta, putative 0.0023 0.0116 0.0789
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0116 0.1136
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0325 0.0793
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.07 1
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0014 0.0018 0.5
Giardia lamblia DINP protein human, muc B family 0.0023 0.0116 0.5

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.8526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 2.8184 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 3.5481 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 3.6611 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.9433 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 7.9433 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (binding) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] ChEMBL. No reference
Potency (functional) 14.7157 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 19.9526 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 21.1923 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 37.933 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 44.6684 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 50.1187 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 58.4789 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of mutant isocitrate dehydrogenase 1 (IDH1): qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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