Detailed information for compound 1628791

Basic information

Technical information
  • TDR Targets ID: 1628791
  • Name: N-phenyl-N-[1-(2-thiophen-2-ylethyl)piperidin -4-yl]propanamide
  • MW: 342.498 | Formula: C20H26N2OS
  • H donors: 0 H acceptors: 1 LogP: 4.02 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC(=O)N(c1ccccc1)C1CCN(CC1)CCc1cccs1
  • InChi: 1S/C20H26N2OS/c1-2-20(23)22(17-7-4-3-5-8-17)18-10-13-21(14-11-18)15-12-19-9-6-16-24-19/h3-9,16,18H,2,10-15H2,1H3
  • InChiKey: YMRFZDHYDKZXPA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-phenyl-N-[1-[2-(2-thienyl)ethyl]-4-piperidyl]propanamide
  • N-phenyl-N-[1-[2-(2-thienyl)ethyl]-4-piperidinyl]propanamide
  • N-phenyl-N-[1-[2-(2-thienyl)ethyl]-4-piperidyl]propionamide
  • 1165-22-6
  • AIDS-143926
  • 5-22-08-00089 (Beilstein Handbook Reference)
  • BRN 0495808
  • DEA No. 9835
  • N-(1-(beta-(2-Thienyl)ethyl)-4-piperidyl)propioanilide
  • N-Phenyl-N-(1-((2-thienyl)ethyl)-4-piperidinyl)propanamide
  • Propionanilide, N-(1-(2-(2-thienyl)ethyl)-4-piperidyl)-
  • Thiofentanyl
  • NCI60_022700
  • AIDS143926
  • N-Phenyl-N-(1-(2-(2-thienyl)ethyl)-4-piperidinyl)propanamide
  • NSC665714

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0041 0.039 0.039
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0039 0.0354 0.0521
Schistosoma mansoni protein kinase 0.0039 0.0354 0.0521
Trichomonas vaginalis AGC family protein kinase 0.0048 0.0493 0.0493
Loa Loa (eye worm) hypothetical protein 0.0041 0.039 0.039
Trypanosoma brucei Serine/threonine-protein kinase NEK21, putative 0.0048 0.0493 0.0493
Brugia malayi Variant SH3 domain containing protein 0.0041 0.039 0.039
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0112 0.1467 0.2162
Echinococcus multilocularis pleckstrin y domain containing family A 0.0041 0.039 0.0575
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0025 0.0141 1
Schistosoma mansoni serine/threonine protein kinase 0.0217 0.3075 0.4529
Trichomonas vaginalis AGC family protein kinase 0.0259 0.3705 0.3705
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0039 0.0357 0.7235
Trypanosoma cruzi PH domain containing protein, putative 0.0041 0.039 0.0575
Plasmodium falciparum calcium-dependent protein kinase 4 0.0039 0.0354 0.05
Echinococcus granulosus calcium dependent protein kinase 0.0032 0.025 0.0369
Plasmodium falciparum proline--tRNA ligase 0.0039 0.0357 0.0504
Echinococcus granulosus beta 1 syntrophin 0.0041 0.039 0.0575
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0025 0.0141 0.0141
Trypanosoma cruzi NIMA-related kinase, putative 0.0048 0.0493 0.0727
Trichomonas vaginalis ribosomal protein S6 kinase, 90kD, polypeptide, putative 0.0048 0.0493 0.0493
Entamoeba histolytica protein kinase, putative 0.0039 0.0354 0.0216
Entamoeba histolytica hypothetical protein 0.0041 0.039 0.0253
Brugia malayi PH domain containing protein 0.0041 0.039 0.039
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0039 0.0357 0.0526
Toxoplasma gondii facilitative glucose transporter GT1 0.0112 0.1467 0.1566
Leishmania major folate/biopterin transporter, putative 0.0048 0.0493 1
Giardia lamblia Lysyl-tRNA synthetase 0.0025 0.0141 0.0229
Trypanosoma cruzi serine/threonine-protein kinase NRKB, putative 0.0048 0.0493 0.0727
Entamoeba histolytica protein kinase, putative 0.0048 0.0493 0.0357
Echinococcus granulosus oxysterol binding protein 1 0.0041 0.039 0.0575
Schistosoma mansoni glucose transport protein 0.0112 0.1467 0.2162
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0041 0.039 0.0253
Leishmania major glucose transporter/membrane transporter D2, putative 0.0035 0.0289 0.5866
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0048 0.0493 1
Leishmania major serine/threonine-protein kinase a, putative 0.0048 0.0493 1
Loa Loa (eye worm) uncoordinated protein 104 0.0041 0.039 0.039
Loa Loa (eye worm) hypothetical protein 0.0041 0.039 0.039
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0048 0.0493 0.0727
Plasmodium vivax oxysterol-binding protein/PH domain containing protein 0.0041 0.039 0.0551
Brugia malayi Protein kinase domain containing protein 0.0217 0.3075 0.3075
Toxoplasma gondii protein kinase, putative 0.0321 0.4655 0.4968
Trypanosoma brucei glucose transporter, putative 0.0035 0.0289 0.0289
Plasmodium falciparum calcium-dependent protein kinase 5 0.0039 0.0354 0.05
Brugia malayi PH domain containing protein 0.0041 0.039 0.039
Loa Loa (eye worm) RhoGEF domain-containing protein 0.0041 0.039 0.039
Echinococcus multilocularis beta 1 syntrophin 0.0041 0.039 0.0575
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0021 0.0084 1
Trichomonas vaginalis protein transport protein sec7, putative 0.0041 0.039 0.039
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.039 0.039
Trichomonas vaginalis AGC family protein kinase 0.0048 0.0493 0.0493
Loa Loa (eye worm) hypothetical protein 0.0034 0.0272 0.0272
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.039 0.039
Toxoplasma gondii hypothetical protein 0.0041 0.039 0.0416
Echinococcus granulosus Pleckstrin y 0.0041 0.039 0.0575
Echinococcus multilocularis oxysterol binding protein 3 0.0041 0.039 0.0575
Loa Loa (eye worm) hypothetical protein 0.0041 0.039 0.039
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0034 0.0272 0.0133
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0034 0.0272 0.0272
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.039 0.039
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0039 0.0354 0.0378
Entamoeba histolytica hypothetical protein 0.0041 0.039 0.0253
Trypanosoma cruzi serine/threonine protein kinase, putative 0.0048 0.0493 0.0727
Entamoeba histolytica hypothetical protein, conserved 0.0041 0.039 0.0253
Loa Loa (eye worm) hypothetical protein 0.0217 0.3075 0.3075
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0041 0.039 0.0253
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0034 0.0272 0.0272
Onchocerca volvulus 0.0041 0.039 1
Echinococcus multilocularis Arf GAP and Pleckstrin domain containing protein 0.0041 0.039 0.0575
Plasmodium falciparum oxysterol-binding protein, putative 0.0041 0.039 0.0551
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0041 0.039 0.0253
Echinococcus granulosus arf GAP with coiled coil ANK repeat and PH 0.0041 0.039 0.0575
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0185 0.259 0.3659
Entamoeba histolytica protein kinase, putative 0.0039 0.0354 0.0216
Echinococcus granulosus type II inositol 34 bisphosphate 4 phosphatase 0.0041 0.039 0.0575
Entamoeba histolytica PH domain containing protein 0.0041 0.039 0.0253
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0112 0.1467 0.2162
Echinococcus granulosus protein kinase c iota type 0.0217 0.3075 0.4529
Trichomonas vaginalis conserved hypothetical protein 0.0112 0.1467 0.1467
Echinococcus multilocularis arf GAP with SH3 domain, ANK repeat and PH 0.0041 0.039 0.0575
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0039 0.0354 0.0521
Onchocerca volvulus Protein melted homolog 0.0041 0.039 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.039 0.039
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0112 0.1467 0.2162
Echinococcus granulosus serine/threonine protein kinase 0.0461 0.6789 1
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.039 0.039
Entamoeba histolytica PH domain containing protein kinase, putative 0.0461 0.6789 0.6743
Echinococcus granulosus dynamin 1 0.0041 0.039 0.0575
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0041 0.039 0.0253
Trypanosoma cruzi PH domain containing protein, putative 0.0041 0.039 0.0575
Echinococcus multilocularis General substrate transporter 0.0096 0.1227 0.1808
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.0048 0.0493 0.0727
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0041 0.039 0.0253
Brugia malayi p70 ribosomal S6 kinase beta 0.063 0.937 0.937
Entamoeba histolytica PH domain containing protein kinase, putative 0.0048 0.0493 0.0357
Echinococcus multilocularis collagen type iv alpha 3 binding protein 0.0041 0.039 0.0575
Echinococcus granulosus myotubularin protein 13 0.0041 0.039 0.0575
Schistosoma mansoni hypothetical protein 0.0041 0.039 0.0575
Echinococcus granulosus Oxysterol binding protein 11 0.0041 0.039 0.0575
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0217 0.3075 0.3075
Plasmodium vivax hexose transporter 0.0112 0.1467 0.2073
Brugia malayi Cytohesin 3 0.0041 0.039 0.039
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0217 0.3075 0.4529
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.063 0.937 0.937
Echinococcus multilocularis type II inositol 3,4 bisphosphate 4 phosphatase 0.0041 0.039 0.0575
Trichomonas vaginalis AGC family protein kinase 0.0048 0.0493 0.0493
Brugia malayi Syntrophin-1 0.0041 0.039 0.039
Leishmania major protein kinase, putative 0.0048 0.0493 1
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0041 0.039 0.0253
Schistosoma mansoni syntrophin 0.0041 0.039 0.0575
Schistosoma mansoni serine/threonine protein kinase 0.0217 0.3075 0.4529
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0413 0.6055 0.8919
Trichomonas vaginalis AGC family protein kinase 0.0671 1 1
Schistosoma mansoni serine/threonine-protein kinase 0.0461 0.6789 1
Schistosoma mansoni dynamin 0.0041 0.039 0.0575
Trypanosoma brucei THT1 - hexose transporter, putative 0.0035 0.0289 0.0289
Plasmodium falciparum acylated pleckstrin-homology domain-containing protein, putative 0.0041 0.039 0.0551
Trypanosoma brucei glucose transporter, putative 0.0035 0.0289 0.0289
Plasmodium falciparum calcium-dependent protein kinase 2 0.0039 0.0354 0.05
Trypanosoma cruzi ADP-ribosylation factor family, putative 0.0041 0.039 0.0575
Onchocerca volvulus Abnormal cell migration protein 10 homolog 0.0041 0.039 1
Brugia malayi PH domain containing protein 0.0041 0.039 0.039
Entamoeba histolytica protein kinase, putative 0.063 0.937 0.9361
Trichomonas vaginalis centaurin/arf, putative 0.0041 0.039 0.039
Trichomonas vaginalis centaurin alpha, putative 0.0041 0.039 0.039
Trypanosoma brucei glucose transporter 1E 0.0035 0.0289 0.0289
Echinococcus granulosus Glutaredoxin protein 5 0.0413 0.6055 0.8919
Echinococcus granulosus pleckstrin y domain containing family A 0.0041 0.039 0.0575
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0041 0.039 0.0253
Loa Loa (eye worm) hypothetical protein 0.0041 0.039 0.039
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0034 0.0272 0.0401
Trichomonas vaginalis centaurin/arf, putative 0.0041 0.039 0.039
Echinococcus multilocularis pdz domain containing protein 0.0041 0.039 0.0575
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0039 0.0357 0.0381
Schistosoma mansoni serine/threonine protein kinase 0.0217 0.3075 0.4529
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0041 0.039 0.0253
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0289 0.0289
Echinococcus multilocularis dynamin 1 0.0041 0.039 0.0575
Schistosoma mansoni growth factor receptor-bound protein 0.0041 0.039 0.0575
Trichomonas vaginalis kinesin light chain, putative 0.0041 0.039 0.039
Schistosoma mansoni protein kinase 0.0039 0.0354 0.0521
Entamoeba histolytica hypothetical protein 0.0041 0.039 0.0253
Entamoeba histolytica protein kinase, putative 0.0048 0.0493 0.0357
Trichomonas vaginalis AGC family protein kinase 0.0217 0.3075 0.3075
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0048 0.0493 0.0727
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0041 0.039 0.0253
Entamoeba histolytica hypothetical protein 0.0048 0.0493 0.0357
Trichomonas vaginalis protein transport protein sec7, putative 0.0041 0.039 0.039
Echinococcus multilocularis oxysterol binding protein 1 0.0041 0.039 0.0575
Schistosoma mansoni protein kinase 0.0039 0.0354 0.0521
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0039 0.0354 0.0378
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0039 0.0354 0.0521
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0048 0.0493 0.0727
Loa Loa (eye worm) PH domain-containing protein 0.0041 0.039 0.039
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0041 0.039 0.039
Onchocerca volvulus outspread protein homolog 0.0041 0.039 1
Trypanosoma cruzi PH domain containing protein, putative 0.0041 0.039 0.0575
Plasmodium falciparum mitogen-activated protein kinase 2 0.0185 0.259 0.3659
Onchocerca volvulus 0.0041 0.039 1
Toxoplasma gondii AtPH1 family protein 0.0041 0.039 0.0416
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0041 0.039 0.0253
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0112 0.1467 0.2162
Onchocerca volvulus 0.0041 0.039 1
Plasmodium vivax CDK-related protein kinase 6, putative 0.048 0.7078 1
Schistosoma mansoni zinc finger protein 0.0041 0.039 0.0575
Brugia malayi lysyl-tRNA synthetase 0.0025 0.0141 0.0141
Echinococcus multilocularis oxysterol binding protein 9 0.0041 0.039 0.0575
Schistosoma mansoni serine/threonine protein kinase 0.0217 0.3075 0.4529
Echinococcus multilocularis cytohesin 1 0.0041 0.039 0.0575
Brugia malayi GTPase-activator protein for Ras-like GTPase containing protein 0.0041 0.039 0.039
Trypanosoma brucei glucose transporter, putative 0.0035 0.0289 0.0289
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0039 0.0354 0.0521
Entamoeba histolytica protein kinase, putative 0.0048 0.0493 0.0357
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.039 0.039
Onchocerca volvulus Putative neuronal RhoA GEF protein 0.0041 0.039 1
Brugia malayi PH domain containing protein 0.0041 0.039 0.039
Schistosoma mansoni oxysterol-binding protein 1 0.0041 0.039 0.0575
Trypanosoma brucei NEK family Serine/threonine-protein kinase, putative 0.0048 0.0493 0.0493
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0039 0.0354 0.05
Trypanosoma cruzi hexose transporter 0.0035 0.0289 0.0426
Trichomonas vaginalis AGC family protein kinase 0.0048 0.0493 0.0493
Trypanosoma cruzi hypothetical protein 0.0041 0.039 0.0575
Echinococcus multilocularis Pleckstrin domain containing protein, family B 0.0041 0.039 0.0575
Brugia malayi PH domain containing protein 0.0041 0.039 0.039
Trichomonas vaginalis ankyrin 2,3/unc44, putative 0.0041 0.039 0.039
Trypanosoma cruzi hexose transporter, putative 0.0035 0.0289 0.0426
Echinococcus multilocularis Oxysterol binding protein 11 0.0041 0.039 0.0575
Onchocerca volvulus 0.0041 0.039 1
Entamoeba histolytica PH domain containing protein kinase, putative 0.0461 0.6789 0.6743
Plasmodium vivax hypothetical protein, conserved 0.0041 0.039 0.0551
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0039 0.0354 0.0521
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.039 0.039
Toxoplasma gondii AGC kinase 0.063 0.937 1
Schistosoma mansoni zinc finger protein 0.0041 0.039 0.0575
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0041 0.039 0.0551
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0034 0.0272 0.0401
Loa Loa (eye worm) AGC/AKT protein kinase 0.0671 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.039 0.039
Giardia lamblia Kinase, AGC PKA 0.0419 0.6159 1
Brugia malayi hypothetical protein 0.0041 0.039 0.039
Trichomonas vaginalis AGC family protein kinase 0.0048 0.0493 0.0493
Entamoeba histolytica pleckstrin homology (PH) domain containing protein 0.0041 0.039 0.0253
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0048 0.0493 0.0727
Trichomonas vaginalis CAMK family protein kinase 0.0039 0.0354 0.0354
Echinococcus granulosus nervana 2 0.0413 0.6055 0.8919
Loa Loa (eye worm) AGC/NDR protein kinase 0.0217 0.3075 0.3075
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0025 0.0141 0.0141
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0039 0.0354 0.0521
Trichomonas vaginalis AGC family protein kinase 0.0048 0.0493 0.0493
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0217 0.3075 0.4529
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0034 0.0272 0.0401
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.039 0.039
Echinococcus multilocularis arf GAP with coiled coil, ANK repeat and PH 0.0041 0.039 0.0575
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0039 0.0354 0.0378
Brugia malayi Plekhf2 protein 0.0041 0.039 0.039
Brugia malayi Cadps2 protein 0.0041 0.039 0.039
Echinococcus multilocularis serine threonine protein kinase 0.0217 0.3075 0.4529
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0041 0.039 0.0253
Trichomonas vaginalis AGC family protein kinase 0.0671 1 1
Echinococcus granulosus FERM and pleckstrin domain containing protein 0.0041 0.039 0.0575
Echinococcus granulosus protein kinase C gamma type 0.0217 0.3075 0.4529
Trichomonas vaginalis centaurin beta, putative 0.0041 0.039 0.039
Loa Loa (eye worm) hypothetical protein 0.0025 0.0141 0.0141
Entamoeba histolytica PH domain containing protein kinase, putative 0.0048 0.0493 0.0357
Loa Loa (eye worm) hypothetical protein 0.0041 0.039 0.039
Trypanosoma brucei glucose transporter, putative 0.0035 0.0289 0.0289
Echinococcus multilocularis serine:threonine protein kinase N2 0.0217 0.3075 0.4529
Leishmania major hypothetical protein, conserved 0.0041 0.039 0.7904
Echinococcus granulosus Pleckstrin y 0.0041 0.039 0.0575
Leishmania major glucose transporter, lmgt2 0.0035 0.0289 0.5866
Trypanosoma cruzi PH domain containing protein, putative 0.0041 0.039 0.0575
Trypanosoma brucei PH domain containing protein, putative 0.0041 0.039 0.039
Entamoeba histolytica protein kinase, putative 0.0217 0.3075 0.2975
Entamoeba histolytica protein kinase, putative 0.0048 0.0493 0.0357
Trichomonas vaginalis glucose transporter, putative 0.0035 0.0289 0.0289
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0025 0.0141 0.0208
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0039 0.0354 0.05
Trichomonas vaginalis AGC family protein kinase 0.0671 1 1
Trichomonas vaginalis AGC family protein kinase 0.0048 0.0493 0.0493
Echinococcus multilocularis ras specific guanine nucleotide releasing factor 0.0041 0.039 0.0575
Brugia malayi Pleckstrin Homology Domain 0.0041 0.039 0.039
Trichomonas vaginalis AGC family protein kinase 0.0671 1 1
Schistosoma mansoni glucose transport protein 0.0112 0.1467 0.2162
Brugia malayi PH domain containing protein 0.0041 0.039 0.039
Schistosoma mansoni hypothetical protein 0.0041 0.039 0.0575
Echinococcus granulosus Rho GTPase activating protein 24 0.0041 0.039 0.0575
Echinococcus granulosus oxysterol binding protein 9 0.0041 0.039 0.0575
Echinococcus granulosus ras specific guanine nucleotide releasing factor 0.0041 0.039 0.0575
Entamoeba histolytica PH domain containing protein 0.0041 0.039 0.0253
Brugia malayi MAX-1A 0.0041 0.039 0.039
Entamoeba histolytica hypothetical protein 0.0041 0.039 0.0253
Echinococcus granulosus calcium dependent secretion activator 1 0.0041 0.039 0.0575
Trichomonas vaginalis AGC family protein kinase 0.0048 0.0493 0.0493
Giardia lamblia Prolyl-tRNA synthetase 0.0034 0.0272 0.0442
Loa Loa (eye worm) hypothetical protein 0.0041 0.039 0.039
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0025 0.0141 0.3046
Brugia malayi Variant SH3 domain containing protein 0.0041 0.039 0.039
Schistosoma mansoni centaurin alpha 0.0041 0.039 0.0575
Entamoeba histolytica p21-activated kinase 0.0048 0.0493 0.0357
Trichomonas vaginalis sugar transporter, putative 0.0035 0.0289 0.0289
Schistosoma mansoni atypical protein kinase C 0.0217 0.3075 0.4529
Plasmodium falciparum protein kinase 6 0.048 0.7078 1
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.039 0.039
Toxoplasma gondii calcium dependent protein kinase CDPK7 0.0048 0.0493 0.0527
Loa Loa (eye worm) syntrophin-1 0.0041 0.039 0.039
Schistosoma mansoni serine/threonine kinase 0.0217 0.3075 0.4529
Schistosoma mansoni dynamin 0.0041 0.039 0.0575
Leishmania major protein kinase, putative 0.0048 0.0493 1
Loa Loa (eye worm) sugar transporter 0.0112 0.1467 0.1467
Echinococcus multilocularis actin binding protein anillin 0.0041 0.039 0.0575
Toxoplasma gondii lysine-tRNA ligase 0.0025 0.0141 0.0151
Onchocerca volvulus 0.0041 0.039 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.039 0.039
Echinococcus granulosus cytohesin 1 0.0041 0.039 0.0575
Echinococcus multilocularis GRB2 associated binding protein 3 0.0041 0.039 0.0575
Entamoeba histolytica ARF GTPase activating protein, putative 0.0041 0.039 0.0253
Schistosoma mansoni hypothetical protein 0.0041 0.039 0.0575
Plasmodium vivax PH domain containing protein 0.0041 0.039 0.0551
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0039 0.0354 0.0521
Plasmodium falciparum calcium-dependent protein kinase 1 0.0039 0.0354 0.05
Plasmodium falciparum lysine--tRNA ligase 0.0025 0.0141 0.0199
Toxoplasma gondii Oxysterol-binding protein 0.0041 0.039 0.0416
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0112 0.1467 0.2162
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0039 0.0354 0.0354
Loa Loa (eye worm) hypothetical protein 0.0041 0.039 0.039
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0016 0 0.5
Plasmodium vivax calcium-dependent protein kinase 7, putative 0.0048 0.0493 0.0697
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.0041 0.039 0.0575
Toxoplasma gondii protein kinase domain-containing protein 0.0048 0.0493 0.0527
Echinococcus multilocularis DCC interacting protein 13 beta 0.0041 0.039 0.0575
Echinococcus multilocularis FERM and pleckstrin domain containing protein 0.0041 0.039 0.0575
Schistosoma mansoni serine/threonine protein kinase 0.0217 0.3075 0.4529
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0289 0.0289
Trichomonas vaginalis AGC family protein kinase 0.0217 0.3075 0.3075
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0041 0.039 0.0551
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0461 0.6789 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.039 0.039
Schistosoma mansoni lysyl-tRNA synthetase 0.0025 0.0141 0.0208
Loa Loa (eye worm) AGC/PKN protein kinase 0.0217 0.3075 0.3075
Onchocerca volvulus Putative zinc finger protein 0.0041 0.039 1
Trichomonas vaginalis centaurin gamma, putative 0.0041 0.039 0.039
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0039 0.0354 0.0354
Echinococcus multilocularis Pleckstrin y 0.0041 0.039 0.0575
Echinococcus multilocularis protein kinase c epsilon type 0.0217 0.3075 0.4529
Trypanosoma cruzi hexose transporter, putative 0.0019 0.0049 0.0073
Leishmania major glucose transporter, lmgt1 0.0035 0.0289 0.5866
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0041 0.039 0.0253
Loa Loa (eye worm) oxysterol binding protein 0.0041 0.039 0.039
Trypanosoma cruzi hypothetical protein 0.0041 0.039 0.0575
Trichomonas vaginalis AGC family protein kinase 0.0048 0.0493 0.0493
Schistosoma mansoni development and differentiation-enhancing factor ddef 0.0041 0.039 0.0575
Leishmania major glucose transporter, lmgt3 0.0035 0.0289 0.5866
Trichomonas vaginalis AGC family protein kinase 0.0048 0.0493 0.0493
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0025 0.0141 1
Echinococcus multilocularis nervana 2 0.0413 0.6055 0.8919
Echinococcus multilocularis Rho GTPase activating protein 24 0.0041 0.039 0.0575
Trypanosoma cruzi hypothetical protein 0.0041 0.039 0.0575
Trichomonas vaginalis development and differentiation-enhancing factor, ddef, putative 0.0041 0.039 0.039
Plasmodium falciparum protein kinase 7 0.0321 0.4655 0.6577
Loa Loa (eye worm) hypothetical protein 0.0041 0.039 0.039
Echinococcus granulosus serine:threonine protein kinase N2 0.0217 0.3075 0.4529
Leishmania major protein kinase, putative,serine/threonine protein kinase, putative 0.0048 0.0493 1
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0354 0.0521
Brugia malayi Uncoordinated protein 104 0.0041 0.039 0.039
Plasmodium falciparum calcium-dependent protein kinase 7 0.0048 0.0493 0.0697
Echinococcus multilocularis Ras associated and pleckstrin y 0.0041 0.039 0.0575
Echinococcus granulosus serine threonine protein kinase nrc 0.0419 0.6159 0.9072
Echinococcus multilocularis serine:threonine protein kinase 38 0.0217 0.3075 0.4529
Plasmodium falciparum PH domain-containing protein, putative 0.0041 0.039 0.0551
Echinococcus granulosus protein kinase c epsilon type 0.0217 0.3075 0.4529
Brugia malayi GTP-ase activating protein for Arf containing protein 0.0041 0.039 0.039
Trypanosoma cruzi Protein kinase B 0.0461 0.6789 1
Schistosoma mansoni hypothetical protein 0.0112 0.1467 0.2162
Echinococcus granulosus Pleckstrin domain containing protein family B 0.0041 0.039 0.0575
Schistosoma mansoni glucose transport protein 0.0112 0.1467 0.2162
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0039 0.0354 0.05
Schistosoma mansoni hypothetical protein 0.0041 0.039 0.0575
Trypanosoma brucei protein kinase, putative 0.0048 0.0493 0.0493
Trichomonas vaginalis sugar transporter, putative 0.0035 0.0289 0.0289
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0217 0.3075 0.4529
Entamoeba histolytica protein kinase 2, putative 0.0419 0.6159 0.6104
Trichomonas vaginalis alpha chimerin, putative 0.0041 0.039 0.039
Leishmania major lysyl-tRNA synthetase, putative 0.0025 0.0141 0.2858
Entamoeba histolytica protein kinase, putative 0.0671 1 1
Brugia malayi protein kinase C II. 0.0217 0.3075 0.3075
Loa Loa (eye worm) hypothetical protein 0.0027 0.0176 0.0176
Brugia malayi probable spectrin beta chain 0.0041 0.039 0.039
Brugia malayi Dynamin 0.0041 0.039 0.039
Schistosoma mansoni oxysterol-binding protein 1 0.0041 0.039 0.0575
Trypanosoma brucei serine/threonine-protein kinase NRKB, putative 0.0048 0.0493 0.0493
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0217 0.3075 0.4529
Trichomonas vaginalis AGC family protein kinase 0.0048 0.0493 0.0493
Schistosoma mansoni rho gtpase activating protein 0.0041 0.039 0.0575
Schistosoma mansoni vav2 0.0041 0.039 0.0575
Brugia malayi Oxysterol-binding protein 0.0041 0.039 0.039
Trichomonas vaginalis guanyl-nucleotide exchange factor, putative 0.0041 0.039 0.039
Onchocerca volvulus 0.0041 0.039 1
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.039 0.039
Leishmania major protein kinase, putative 0.0039 0.0354 0.7164
Trypanosoma cruzi NIMA-related kinase, putative 0.0048 0.0493 0.0727
Echinococcus multilocularis calcium dependent protein kinase 0.0032 0.025 0.0369
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.039 0.039
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.039 0.039
Trichomonas vaginalis AGC family protein kinase 0.0217 0.3075 0.3075
Echinococcus granulosus lysyl tRNA synthetase 0.0025 0.0141 0.0208
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0039 0.0357 0.0357
Trypanosoma brucei glucose transporter, putative 0.0035 0.0289 0.0289
Trypanosoma brucei serine/threonine-protein kinase NrkA 0.0048 0.0493 0.0493
Plasmodium falciparum calcium-dependent protein kinase 3 0.0039 0.0354 0.05
Loa Loa (eye worm) hypothetical protein 0.0039 0.0354 0.0354
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0039 0.0354 0.0521
Echinococcus multilocularis protein kinase c iota type 0.0217 0.3075 0.4529
Trichomonas vaginalis 3-phosphoinositide dependent protein kinase-1, putative 0.0048 0.0493 0.0493
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.039 0.039
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0217 0.3075 0.4529
Echinococcus multilocularis lysyl tRNA synthetase 0.0025 0.0141 0.0208
Loa Loa (eye worm) hypothetical protein 0.0041 0.039 0.039
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0021 0.0084 1
Loa Loa (eye worm) Plekhf2 protein 0.0041 0.039 0.039
Loa Loa (eye worm) hypothetical protein 0.0041 0.039 0.039
Echinococcus multilocularis Glutaredoxin protein 5 0.0413 0.6055 0.8919
Loa Loa (eye worm) rho-GTPase-activating 0.0041 0.039 0.039
Brugia malayi TBC domain containing protein 0.0041 0.039 0.039
Trichomonas vaginalis AGC family protein kinase 0.0671 1 1
Trypanosoma brucei rac serine-threonine kinase, putative 0.0671 1 1
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0217 0.3075 0.4529
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0217 0.3075 0.3075
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0217 0.3075 0.3075
Trichomonas vaginalis sugar transporter, putative 0.0035 0.0289 0.0289
Trypanosoma cruzi hypothetical protein 0.0041 0.039 0.0575
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0041 0.039 0.0253
Schistosoma mansoni serine/threonine protein kinase 0.0217 0.3075 0.4529
Trypanosoma brucei THT1 - hexose transporter, putative 0.0035 0.0289 0.0289
Plasmodium falciparum hexose transporter 0.0112 0.1467 0.2073
Entamoeba histolytica PH domain containing protein kinase, putative 0.0048 0.0493 0.0357
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0034 0.0272 0.0272
Schistosoma mansoni myotubularin-related protein 0.0041 0.039 0.0575
Plasmodium vivax calcium-dependent protein kinase, putative 0.0039 0.0354 0.05
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0039 0.0354 0.0354
Trichomonas vaginalis AGC family protein kinase 0.0048 0.0493 0.0493
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0039 0.0357 0.7235
Loa Loa (eye worm) hypothetical protein 0.0041 0.039 0.039
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0041 0.039 0.0253
Brugia malayi PH domain containing protein 0.0041 0.039 0.039
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0185 0.259 0.2764
Trichomonas vaginalis AGC family protein kinase 0.0048 0.0493 0.0493
Loa Loa (eye worm) hypothetical protein 0.0041 0.039 0.039
Trichomonas vaginalis AGC family protein kinase 0.0048 0.0493 0.0493
Trypanosoma cruzi hypothetical protein 0.0041 0.039 0.0575
Trypanosoma cruzi hexose transporter, putative 0.0035 0.0289 0.0426
Brugia malayi PH domain containing protein 0.0041 0.039 0.039
Echinococcus granulosus GRB2 associated binding protein 3 0.0041 0.039 0.0575
Toxoplasma gondii phosphatidylinositol transfer protein 0.0041 0.039 0.0416
Echinococcus multilocularis serine:threonine protein kinase N2 0.0217 0.3075 0.4529
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0217 0.3075 0.3075
Schistosoma mansoni phosphoinositol 4-phosphate adaptor protein 0.0041 0.039 0.0575
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0419 0.6159 0.8701
Entamoeba histolytica PH domain containing protein kinase, putative 0.0048 0.0493 0.0357
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0039 0.0354 0.0354
Schistosoma mansoni serine/threonine protein kinase 0.0217 0.3075 0.4529
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.039 0.039
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0419 0.6159 0.9072
Loa Loa (eye worm) cytohesin 3 0.0041 0.039 0.039
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0112 0.1467 0.2162
Echinococcus multilocularis Pleckstrin y 0.0041 0.039 0.0575
Echinococcus granulosus General substrate transporter 0.0096 0.1227 0.1808
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.021 0.2971 0.2971
Echinococcus granulosus collagen type iv alpha 3 binding protein 0.0041 0.039 0.0575
Schistosoma mansoni lysyl-tRNA synthetase 0.0025 0.0141 0.0208
Schistosoma mansoni hypothetical protein 0.0041 0.039 0.0575
Entamoeba histolytica protein kinase, putative 0.0048 0.0493 0.0357
Brugia malayi Dynamin 0.0041 0.039 0.039
Schistosoma mansoni goodpasture antigen-binding protein 0.0041 0.039 0.0575
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0112 0.1467 0.2162
Echinococcus granulosus NDR protein kinase 0.0217 0.3075 0.4529
Echinococcus granulosus pdz domain containing protein 0.0041 0.039 0.0575
Echinococcus granulosus Arf GAP and Pleckstrin domain containing protein 0.0041 0.039 0.0575
Trichomonas vaginalis hypothetical protein 0.0041 0.039 0.039
Brugia malayi Protein kinase domain containing protein 0.0217 0.3075 0.3075
Trypanosoma cruzi hexose transporter, putative 0.0035 0.0289 0.0426
Brugia malayi GTP-ase activating protein for Arf containing protein 0.0041 0.039 0.039
Trichomonas vaginalis AGC family protein kinase 0.0671 1 1
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0041 0.039 0.039
Schistosoma mansoni guanyl-nucleotide exchange factor 0.0041 0.039 0.0575
Brugia malayi PH domain containing protein 0.0041 0.039 0.039
Leishmania major hypothetical protein, conserved 0.0041 0.039 0.7904
Trichomonas vaginalis AGC family protein kinase 0.0048 0.0493 0.0493
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.0041 0.039 0.039
Echinococcus granulosus Pleckstrin y 0.0041 0.039 0.0575
Trypanosoma brucei glucose transporter, putative 0.0035 0.0289 0.0289
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0112 0.1467 0.2162
Trypanosoma brucei glucose transporter, putative 0.0035 0.0289 0.0289
Entamoeba histolytica PH domain containing protein 0.0041 0.039 0.0253
Entamoeba histolytica protein kinase, putative 0.0671 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.039 0.039
Onchocerca volvulus 0.0041 0.039 1
Trypanosoma brucei glucose transporter 2A 0.0035 0.0289 0.0289
Echinococcus granulosus oxysterol binding protein 3 0.0041 0.039 0.0575
Brugia malayi Hr1 repeat family protein 0.0217 0.3075 0.3075
Loa Loa (eye worm) hypothetical protein 0.0034 0.0272 0.0272
Trichomonas vaginalis ankyrin repeat and FYVE domain containing protein, putative 0.0041 0.039 0.039
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0419 0.6159 0.9072
Loa Loa (eye worm) hypothetical protein 0.0041 0.039 0.039
Entamoeba histolytica hypothetical protein 0.0041 0.039 0.0253
Echinococcus multilocularis Pleckstrin y 0.0041 0.039 0.0575
Brugia malayi Sugar transporter family protein 0.0112 0.1467 0.1467
Echinococcus granulosus DCC interacting protein 13 beta 0.0041 0.039 0.0575
Loa Loa (eye worm) hypothetical protein 0.0041 0.039 0.039
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0022 0.0094 0.0094
Toxoplasma gondii hypothetical protein 0.0041 0.039 0.0416
Trichomonas vaginalis AGC family protein kinase 0.0048 0.0493 0.0493
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0413 0.6055 0.8919
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0034 0.0272 1
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0041 0.039 0.0575
Echinococcus granulosus arf GAP with SH3 domain ANK repeat and PH 0.0041 0.039 0.0575
Trichomonas vaginalis AGC family protein kinase 0.0048 0.0493 0.0493
Echinococcus multilocularis myotubularin protein 13 0.0041 0.039 0.0575
Trichomonas vaginalis glucose transporter, putative 0.0035 0.0289 0.0289
Trypanosoma brucei glucose transporter, putative 0.0035 0.0289 0.0289
Trypanosoma cruzi hypothetical protein 0.0041 0.039 0.0575
Trichomonas vaginalis AGC family protein kinase 0.0048 0.0493 0.0493
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0041 0.039 0.039
Schistosoma mansoni serine/threonine-protein kinase 0.0461 0.6789 1
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0217 0.3075 0.4529
Echinococcus granulosus nervana 2 0.0413 0.6055 0.8919
Trypanosoma cruzi hypothetical protein 0.0041 0.039 0.0575
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0034 0.0272 0.0401
Plasmodium vivax conserved Plasmodium protein, unknown function 0.0041 0.039 0.0551
Loa Loa (eye worm) hypothetical protein 0.0041 0.039 0.039
Brugia malayi Oxysterol binding protein 0.0041 0.039 0.039
Schistosoma mansoni goodpasture antigen-binding protein 0.0041 0.039 0.0575
Chlamydia trachomatis lysine--tRNA ligase 0.0025 0.0141 0.5
Trichomonas vaginalis AGC family protein kinase 0.0671 1 1
Plasmodium vivax proline--tRNA ligase, putative 0.0039 0.0357 0.0504
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.039 0.039
Echinococcus multilocularis calcium dependent secretion activator 1 0.0041 0.039 0.0575
Brugia malayi Cam kinase protein 1 0.0039 0.0354 0.0354
Echinococcus multilocularis nervana 2 0.0413 0.6055 0.8919
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.0041 0.039 0.039
Plasmodium vivax lysine--tRNA ligase, putative 0.0025 0.0141 0.0199
Schistosoma mansoni rhogef and pleckstrin domain protein 0.0041 0.039 0.0575
Trichomonas vaginalis AGC family protein kinase 0.0048 0.0493 0.0493
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0419 0.6159 0.9072
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.039 0.039
Echinococcus granulosus Protein kinase C brain isozyme 0.0217 0.3075 0.4529
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0419 0.6159 0.8701
Plasmodium falciparum phosphatidylinositol transfer protein, putative 0.0041 0.039 0.0551
Loa Loa (eye worm) hypothetical protein 0.0041 0.039 0.039
Entamoeba histolytica hypothetical protein 0.0048 0.0493 0.0357
Echinococcus multilocularis rac serine:threonine kinase 0.0461 0.6789 1
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0048 0.0493 0.0727
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0039 0.0357 0.0526
Trypanosoma brucei THT1 - hexose transporter, putative 0.0035 0.0289 0.0289
Trichomonas vaginalis AGC family protein kinase 0.0048 0.0493 0.0493

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 0.03 mg kg-1 Antinociceptive activity in sc dosed mouse by tail flick test ChEMBL. 24360563
GI50 (functional) -4.267 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.045 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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