Detailed information for compound 1645590

Basic information

Technical information
  • TDR Targets ID: 1645590
  • Name: Neuro_000176
  • MW: 478.532 | Formula: C25H34O9
  • H donors: 4 H acceptors: 6 LogP: 0.35 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1OC2C(OC(=O)C=C(C)C)C3C(=CC(C(C3(C3C42C(C1)C(C)C(C3(OC4)O)O)C)O)O)C
  • InChi: 1S/C25H34O9/c1-10(2)6-15(27)33-18-17-11(3)7-14(26)20(30)23(17,5)22-24-9-32-25(22,31)19(29)12(4)13(24)8-16(28)34-21(18)24/h6-7,12-14,17-22,26,29-31H,8-9H2,1-5H3
  • InChiKey: GHYBVLUUZDLXRW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • SENECIOYLCHAPARRIN, 6-ALPHA- (B815099K220)
  • Picras-3-ene-2,16-dione, 11,20-epoxy-1,11,12-trihydroxy-6-[(3-methyl-1-oxo-2-butenyl)oxy]-, (6.alpha.,11.beta.,12.alpha.)-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0185 0.0766
Loa Loa (eye worm) hypothetical protein 0.0035 0.0185 0.0349
Echinococcus multilocularis thioredoxin glutathione reductase 0.0041 0.0235 0.0324
Echinococcus multilocularis transient receptor potential gamma protein 0.0109 0.0833 0.115
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0026 0.0104 0.1735
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0054 0.0087
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0016 0.0016 0.0062
Loa Loa (eye worm) hypothetical protein 0.0081 0.0592 0.1186
Brugia malayi Cache domain containing protein 0.0169 0.1361 0.279
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0185 0.0198
Onchocerca volvulus 0.008 0.0578 0.279
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0018 0.0038 0.0481
Loa Loa (eye worm) hypothetical protein 0.0081 0.0592 0.1186
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0054 0.0073
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0181 0.0248
Mycobacterium ulcerans glutaminase 0.0288 0.2408 0.2407
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0075 0.0102
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0054 0.0057
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0366 0.3089 0.504
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0185 0.0255
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0039 0.0219 0.3688
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0054 0.1664
Echinococcus granulosus JmjC domain containing protein 4 0.0018 0.0038 0.0052
Chlamydia trachomatis protoporphyrinogen oxidase 0.0081 0.0592 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0054 0.1664
Brugia malayi Calcitonin receptor-like protein seb-1 0.0109 0.0832 0.1705
Trichomonas vaginalis AGC family protein kinase 0.0102 0.0777 0.3224
Brugia malayi latrophilin 2 splice variant baaae 0.0074 0.0531 0.1087
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0018 0.0041 0.0043
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0185 0.0766
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0025 0.01 0.1667
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0185 0.3118
Loa Loa (eye worm) hypothetical protein 0.0035 0.0185 0.0349
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0156 0.0253
Schistosoma mansoni hypothetical protein 0.0074 0.0531 0.0864
Schistosoma mansoni jumonji/arid domain-containing protein 0.007 0.0492 0.0801
Treponema pallidum 76K protein 0.0016 0.0016 1
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0185 0.0198
Brugia malayi Cytochrome P450 family protein 0.0018 0.0041 0.0082
Loa Loa (eye worm) hypothetical protein 0.0032 0.0156 0.0288
Echinococcus granulosus muscleblind protein 0.0299 0.2505 0.3461
Brugia malayi Zona pellucida-like domain containing protein 0.0016 0.0016 0.0031
Echinococcus multilocularis geminin 0.0371 0.3135 0.4332
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0185 0.0184
Mycobacterium ulcerans oxidoreductase 0.0081 0.0592 0.0591
Schistosoma mansoni hypothetical protein 0.0016 0.0016 0.0024
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0054 0.0053
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0326 0.4185
Schistosoma mansoni lipoxygenase 0.0087 0.0642 0.1047
Brugia malayi von Willebrand factor type A domain containing protein 0.0016 0.0016 0.0031
Plasmodium vivax ataxin-2 like protein, putative 0.0051 0.0326 0.4185
Schistosoma mansoni hypothetical protein 0.0018 0.0041 0.0065
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0018 0.0041 0.004
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0018 0.0041 0.004
Brugia malayi Cytochrome P450 family protein 0.0078 0.0567 0.116
Schistosoma mansoni rotamase 0.0035 0.019 0.0308
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0054 0.0897
Toxoplasma gondii von Willebrand factor type A domain-containing protein 0.0016 0.0016 0.0193
Echinococcus multilocularis indoleamine 2,3 dioxygenase 2 0.0569 0.4874 0.6735
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0156 0.1994
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0145 0.1849
Onchocerca volvulus 0.0081 0.0592 0.2861
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0054 0.1664
Loa Loa (eye worm) jmjC domain-containing protein 0.0018 0.0038 0.0046
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0075 0.0151
Echinococcus granulosus Polycystic kidney disease protein 0.0021 0.0062 0.0084
Echinococcus multilocularis lysine specific demethylase 6a 0.0018 0.0038 0.0052
Trichomonas vaginalis guanylate cyclase, putative 0.0025 0.01 0.0409
Echinococcus granulosus TRP transient receptor potential channel 0.004 0.0234 0.0322
Brugia malayi Importin beta-1 subunit 0.003 0.0145 0.0294
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0185 0.2375
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0018 0.0041 0.004
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0156 0.0253
Loa Loa (eye worm) doublecortin family protein 0.0021 0.0062 0.0094
Echinococcus granulosus lysine specific histone demethylase 1A 0.0081 0.0592 0.0817
Entamoeba histolytica Ran family GTPase 0.0022 0.0075 0.019
Schistosoma mansoni tar DNA-binding protein 0.0063 0.043 0.07
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0099 0.0745 0.1028
Echinococcus granulosus snurportin 1 0.0323 0.271 0.3744
Loa Loa (eye worm) cytochrome P450 0.0018 0.0041 0.0051
Loa Loa (eye worm) cytochrome P450 family protein 0.0078 0.0567 0.1133
Mycobacterium tuberculosis Conserved protein 0.0035 0.0185 0.0198
Leishmania major DNA polymerase kappa, putative 0.002 0.0054 0.0897
Echinococcus granulosus short transient receptor potential channel 6 0.0072 0.051 0.0704
Brugia malayi von Willebrand factor type A domain containing protein 0.0016 0.0016 0.0031
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0014 0.0001 0.0037
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0145 0.4438
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0094 0.1579
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0025 0.01 0.1667
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0181 0.0369
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0025 0.01 0.0136
Brugia malayi PAS domain containing protein 0.0097 0.0727 0.1489
Echinococcus granulosus RUN 0.0021 0.0062 0.0084
Loa Loa (eye worm) hepatopoietin HPO2 0.0039 0.0219 0.0418
Leishmania major hypothetical protein, conserved 0.0051 0.0326 0.5494
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0062 0.0084
Schistosoma mansoni hypothetical protein 0.0034 0.0181 0.0293
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0185 0.0301
Brugia malayi von Willebrand Factor 0.0016 0.0016 0.0031
Schistosoma mansoni transcription factor LCR-F1 0.0072 0.051 0.083
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0072 0.051 0.0703
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0054 0.022
Schistosoma mansoni hypothetical protein 0.0323 0.271 0.4422
Schistosoma mansoni polycystin 1-related 0.0021 0.0062 0.0099
Loa Loa (eye worm) hypothetical protein 0.0035 0.0185 0.0349
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0081 0.0592 0.0965
Leishmania major GTP-binding protein, putative 0.0022 0.0075 0.1243
Mycobacterium ulcerans putative regulatory protein 0.0071 0.0507 0.0505
Onchocerca volvulus 0.0032 0.0156 0.0694
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0018 0.0041 0.004
Brugia malayi CXXC zinc finger family protein 0.0032 0.0162 0.0329
Brugia malayi von Willebrand factor type A domain containing protein 0.0016 0.0016 0.0031
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0018 0.0041 0.004
Echinococcus granulosus tar DNA binding protein 0.0063 0.043 0.0592
Brugia malayi hypothetical protein 0.0021 0.0062 0.0125
Onchocerca volvulus 0.0035 0.0185 0.0841
Leishmania major DNA polymerase eta, putative 0.002 0.0054 0.0897
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0075 0.1243
Loa Loa (eye worm) hypothetical protein 0.0037 0.0202 0.0383
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0162 0.03
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0054 0.0897
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0062 0.0084
Brugia malayi hypothetical protein 0.0016 0.0016 0.0031
Schistosoma mansoni jumonji domain containing protein 0.0068 0.0476 0.0775
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0054 0.1664
Loa Loa (eye worm) TAR-binding protein 0.0063 0.043 0.0852
Entamoeba histolytica hypothetical protein 0.0072 0.051 0.1598
Schistosoma mansoni hypothetical protein 0.0034 0.0181 0.0293
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0039 0.0219 0.6726
Plasmodium falciparum LCCL domain-containing protein 0.0021 0.0062 0.0782
Schistosoma mansoni phd/f-box containing protein 0.0018 0.0038 0.0061
Leishmania major hypothetical protein, conserved 0.0035 0.0185 0.3118
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0018 0.0041 0.004
Trichomonas vaginalis adenylate cyclase, putative 0.0025 0.01 0.0409
Leishmania major hypothetical protein, conserved 0.0039 0.0219 0.3688
Toxoplasma gondii ABC1 family protein 0.0035 0.0185 0.2375
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0185 0.0301
Echinococcus granulosus dna polymerase eta 0.002 0.0054 0.0073
Brugia malayi beta-lactamase family protein 0.0035 0.0185 0.0378
Echinococcus multilocularis jun protein 0.0101 0.0769 0.1061
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0075 0.1243
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0025 0.01 0.0136
Schistosoma mansoni hypothetical protein 0.0197 0.1608 0.2622
Trypanosoma brucei unspecified product 0.002 0.0054 0.1664
Echinococcus multilocularis GPCR, family 2 0.0034 0.0181 0.0248
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0018 0.0041 0.004
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0039 0.0219 0.281
Schistosoma mansoni serine-rich repeat protein 0.0197 0.1608 0.2622
Brugia malayi Muscleblind-like protein 0.0299 0.2505 0.5138
Brugia malayi amine oxidase, flavin-containing family protein 0.0081 0.0592 0.1213
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0075 0.0947
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0185 0.0255
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0054 0.1664
Giardia lamblia Kinase, NEK 0.0102 0.0777 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0234 0.0449
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0081 0.0592 0.0817
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0018 0.0041 0.004
Brugia malayi hypoxia-induced factor 1 0.0299 0.2502 0.5132
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0091 0.068 0.0731
Toxoplasma gondii histone lysine-specific demethylase 0.0081 0.0592 0.7617
Schistosoma mansoni hypothetical protein 0.0034 0.0181 0.0293
Plasmodium falciparum thrombospondin-related anonymous protein 0.0016 0.0016 0.0193
Loa Loa (eye worm) hypothetical protein 0.0068 0.0478 0.0952
Echinococcus granulosus lysine specific demethylase 5A 0.007 0.0492 0.0678
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0075 0.0947
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.01 0.0409
Trichomonas vaginalis guanylate cyclase, putative 0.0025 0.01 0.0409
Schistosoma mansoni hypothetical protein 0.0371 0.3135 0.5116
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0018 0.0041 0.0043
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0054 0.0897
Loa Loa (eye worm) hypothetical protein 0.0018 0.0038 0.0046
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0054 0.0897
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0018 0.0041 0.0043
Brugia malayi RNA binding protein 0.0063 0.043 0.088
Schistosoma mansoni aryl hydrocarbon receptor 0.0097 0.0727 0.1185
Echinococcus multilocularis transfer RNA-Lys 0.0071 0.0507 0.0699
Schistosoma mansoni hypothetical protein 0.0023 0.008 0.0128
Mycobacterium leprae Possible regulatory protein 0.0025 0.01 0.0805
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0039 0.0219 0.0301
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0054 0.0053
Echinococcus multilocularis transient receptor potential ion channel A 0.0105 0.0801 0.1106
Loa Loa (eye worm) hypothetical protein 0.0081 0.0592 0.1186
Brugia malayi jmjC domain containing protein 0.0068 0.0476 0.0974
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0054 0.1664
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0026 0.0104 0.1735
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0054 0.0897
Echinococcus granulosus geminin 0.0371 0.3135 0.4332
Brugia malayi hypothetical protein 0.0072 0.051 0.1043
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0099 0.0745 0.1214
Plasmodium vivax circumsporozoite- and TRAP-related protein, putative 0.0016 0.0016 0.0193
Toxoplasma gondii LsmAD domain-containing protein 0.0051 0.0326 0.4185
Plasmodium vivax SET domain protein, putative 0.0032 0.0156 0.1994
Toxoplasma gondii Erv1 / Alr family protein 0.0039 0.0219 0.281
Toxoplasma gondii Erv1 / Alr family protein 0.0039 0.0219 0.281
Onchocerca volvulus 0.0071 0.0507 0.2435
Brugia malayi cytochrome P450 0.0018 0.0041 0.0082
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0018 0.0041 0.0043
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0018 0.0041 0.004
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0039 0.0219 0.281
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0054 0.1664
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0054 0.022
Brugia malayi von Willebrand factor type A domain containing protein 0.0016 0.0016 0.0031
Schistosoma mansoni ran 0.0022 0.0075 0.012
Echinococcus multilocularis expressed protein 0.0035 0.019 0.026
Schistosoma mansoni DNA polymerase eta 0.002 0.0054 0.0087
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0156 0.0253
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0101 0.0769 0.1061
Brugia malayi jmjC domain containing protein 0.0018 0.0038 0.0077
Loa Loa (eye worm) glutaminase 2 0.0288 0.2408 0.4924
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0018 0.0041 0.0043
Mycobacterium leprae Probable lipase LipE 0.0035 0.0185 0.1982
Mycobacterium tuberculosis Possible oxidoreductase 0.0081 0.0592 0.0636
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0018 0.0041 0.1259
Schistosoma mansoni importin beta-1 0.003 0.0145 0.0234
Schistosoma mansoni cytochrome P450 0.0018 0.0041 0.0065
Echinococcus multilocularis collagen alpha 1(VII) chain 0.0016 0.0016 0.0021
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0091 0.068 0.8774
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0185 0.0349
Echinococcus multilocularis tar DNA binding protein 0.0063 0.043 0.0592
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0181 0.0248
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0018 0.0038 0.1181
Mycobacterium ulcerans hypothetical protein 0.0035 0.0185 0.0184
Mycobacterium tuberculosis Conserved hypothetical protein 0.0081 0.0592 0.0636
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0091 0.068 0.0731
Brugia malayi TAR-binding protein 0.0063 0.043 0.088
Plasmodium vivax von Willebrand factor A domain-related protein, putative 0.0016 0.0016 0.0193
Echinococcus multilocularis JmjC domain containing protein 4 0.0018 0.0038 0.0052
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0081 0.0592 0.7617
Onchocerca volvulus 0.0035 0.0185 0.0841
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0039 0.0219 0.0301
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.008 0.0109
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.043 0.0852
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0081 0.0592 0.7617
Leishmania major hypothetical protein, conserved 0.0018 0.0038 0.0631
Echinococcus granulosus lysine specific histone demethylase 1A 0.0081 0.0592 0.0817
Schistosoma mansoni transient receptor potential channel 0.0072 0.051 0.0831
Plasmodium vivax thioredoxin reductase, putative 0.004 0.0231 0.2957
Plasmodium falciparum von Willebrand factor A domain-related protein 0.0016 0.0016 0.0193
Onchocerca volvulus 0.0245 0.203 1
Plasmodium falciparum circumsporozoite- and TRAP-related protein 0.0016 0.0016 0.0193
Leishmania major cytochrome p450-like protein 0.0018 0.0041 0.0674
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0326 0.5494
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0075 0.0102
Echinococcus multilocularis aryl hydrocarbon receptor 0.0025 0.01 0.0136
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0054 0.0109
Toxoplasma gondii histone lysine methyltransferase SET1 0.0062 0.0424 0.545
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0099 0.0745 0.1028
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0156 0.0214
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0054 0.1664
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0075 0.0947
Echinococcus multilocularis dna polymerase kappa 0.002 0.0054 0.0073
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0054 0.0057
Loa Loa (eye worm) hypothetical protein 0.0081 0.0592 0.1186
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0018 0.0041 0.0043
Echinococcus granulosus collagen alpha 1VII chain 0.0016 0.0016 0.0021
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0018 0.0041 0.0043
Schistosoma mansoni transient receptor potential channel 0.0109 0.0833 0.1358
Schistosoma mansoni rab6-interacting 0.0021 0.0062 0.0099
Brugia malayi hypothetical protein 0.0033 0.0168 0.0342
Brugia malayi indoleamine 2,3-dioxygenase 0.0569 0.4874 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0223 0.1834 0.1974
Loa Loa (eye worm) hypothetical protein 0.0299 0.2505 0.5123
Loa Loa (eye worm) hypothetical protein 0.0035 0.0185 0.0349
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0035 0.019 0.0357
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0035 0.0182 0.3063
Trypanosoma brucei trypanothione reductase 0.004 0.0231 0.7077
Echinococcus multilocularis muscleblind protein 1 0.0299 0.2505 0.3461
Loa Loa (eye worm) hypothetical protein 0.0051 0.0326 0.0638
Echinococcus multilocularis voltage dependent calcium channel subunit 0.0839 0.7236 1
Loa Loa (eye worm) beta-lactamase 0.0035 0.0185 0.0349
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0109 0.0832 0.1705
Loa Loa (eye worm) jmjC domain-containing protein 0.0018 0.0038 0.0046
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0099 0.0745 0.15
Brugia malayi Doublecortin family protein 0.0021 0.0062 0.0125
Trypanosoma cruzi cytochrome P450, putative 0.0018 0.0041 0.0674
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.002 0.0055 0.0074
Loa Loa (eye worm) cytochrome P450 family protein 0.0018 0.0041 0.0051
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0018 0.0041 0.0043
Echinococcus multilocularis dna polymerase eta 0.002 0.0054 0.0073
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0181 0.0339
Echinococcus granulosus importin subunit beta 1 0.003 0.0145 0.0198
Echinococcus multilocularis TRP (transient receptor potential) channel 0.004 0.0234 0.0322
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0099 0.0745 0.1214
Trichomonas vaginalis ran, putative 0.0022 0.0075 0.0305
Toxoplasma gondii microneme protein MIC2 0.0016 0.0016 0.0193
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0081 0.0592 0.7617
Echinococcus granulosus cytochrome P450 2K1 0.0018 0.0041 0.0055
Onchocerca volvulus 0.0021 0.0062 0.0227
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0109 0.0832 0.168
Echinococcus multilocularis short transient receptor potential channel 6 0.0072 0.051 0.0704
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0018 0.0041 0.004
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0018 0.0041 0.004
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0014 0.0001 0.0037
Leishmania major UDP-galactopyranose mutase 0.0081 0.0592 1
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.043 0.088
Schistosoma mansoni lipoxygenase 0.0124 0.0971 0.1582
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0184 0.1497 0.2442
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0025 0.01 0.0409
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0081 0.0592 0.7563
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0018 0.0041 0.004
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0185 0.0198
Mycobacterium tuberculosis Probable reductase 0.0091 0.068 0.0731
Brugia malayi jmjC domain containing protein 0.0018 0.0038 0.0077
Schistosoma mansoni hypothetical protein 0.0034 0.0181 0.0293
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0145 0.4438
Echinococcus granulosus microtubule associated protein 2 0.0712 0.6127 0.8467
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0062 0.0084
Loa Loa (eye worm) cytochrome P450 family protein 0.0018 0.0041 0.0051
Brugia malayi Cytochrome P450 family protein 0.0018 0.0041 0.0082
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.004 0.0231 0.0247
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0099 0.0745 0.1028
Loa Loa (eye worm) CYP4Cod1 0.0018 0.0041 0.0051
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0014 0.0001 0.5
Brugia malayi von Willebrand factor type A domain containing protein 0.0016 0.0016 0.0031
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0185 0.3118
Echinococcus granulosus short transient receptor potential channel 6 0.0072 0.051 0.0704
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0018 0.0041 0.0043
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0185 0.0198
Echinococcus granulosus transient receptor potential ion channel A 0.0105 0.0801 0.1106
Schistosoma mansoni tar DNA-binding protein 0.0063 0.043 0.07
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0068 0.0476 0.0656
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0014 0.0001 0.5
Toxoplasma gondii thioredoxin reductase 0.004 0.0231 0.2957
Trypanosoma cruzi UDP-galactopyranose mutase 0.0081 0.0592 1
Schistosoma mansoni hypothetical protein 0.0016 0.0016 0.0024
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0018 0.0041 0.004
Loa Loa (eye worm) RNA binding protein 0.0063 0.043 0.0852
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0156 0.0214
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0326 0.4185
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0025 0.01 0.0409
Schistosoma mansoni hypothetical protein 0.0072 0.051 0.083
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0099 0.0745 0.1527
Schistosoma mansoni hypothetical protein 0.0021 0.0062 0.0099
Giardia lamblia DINP protein human, muc B family 0.002 0.0054 0.0683
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0094 0.0388
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0216 0.177 0.361
Echinococcus multilocularis snurportin 1 0.0323 0.271 0.3744
Echinococcus granulosus jumonji domain containing 1A 0.0018 0.0038 0.0052
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0185 0.0184
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0018 0.0041 0.004
Echinococcus multilocularis Polycystic kidney disease protein 0.0021 0.0062 0.0084
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0054 0.0087
Echinococcus granulosus expressed protein 0.0035 0.019 0.026
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0185 0.1982
Brugia malayi hypothetical protein 0.0324 0.2722 0.5584
Mycobacterium tuberculosis Probable oxidoreductase 0.0102 0.077 0.0828
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0018 0.0041 0.0043
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0075 0.229
Brugia malayi SWIRM domain containing protein 0.0081 0.0592 0.1213
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0014 0.0001 0.0037
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0018 0.0038 0.0631
Schistosoma mansoni hypothetical protein 0.0458 0.3898 0.6362
Leishmania major cytochrome p450-like protein 0.0018 0.0041 0.0674
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0018 0.0041 0.0043
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0326 0.5494
Plasmodium vivax JmjC domain containing protein 0.0018 0.0038 0.0481
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0156 0.0214
Treponema pallidum hypothetical protein 0.0016 0.0016 1
Echinococcus multilocularis importin subunit beta 1 0.003 0.0145 0.0198
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0018 0.0041 0.004
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0035 0.0182 0.3063
Trypanosoma brucei cytochrome P450, putative 0.0018 0.0041 0.1259
Loa Loa (eye worm) hypothetical protein 0.002 0.0054 0.0078
Schistosoma mansoni single-minded 0.0097 0.0727 0.1185
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0035 0.0182 0.3063
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0018 0.0041 0.0043
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0124 0.0971 0.134
Plasmodium vivax importin-beta 2, putative 0.003 0.0145 0.1849
Entamoeba histolytica hypothetical protein 0.0025 0.0094 0.0254
Brugia malayi bHLH-PAS transcription factor 0.0071 0.0507 0.1037
Loa Loa (eye worm) hypothetical protein 0.0368 0.3103 0.6355
Brugia malayi von Willebrand factor type A domain containing protein 0.0016 0.0016 0.0031
Schistosoma mansoni hypothetical protein 0.0371 0.3135 0.5116
Loa Loa (eye worm) hypothetical protein 0.0035 0.0185 0.0349
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0083 0.0609 0.7839
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0054 0.1664
Echinococcus granulosus transient receptor potential gamma protein 0.0109 0.0833 0.115
Echinococcus multilocularis RUN 0.0021 0.0062 0.0084
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0018 0.0041 0.0043
Onchocerca volvulus 0.0021 0.0062 0.0227
Loa Loa (eye worm) hypoxia-induced factor 1 0.0299 0.2502 0.5117
Schistosoma mansoni loxhd1 0.0021 0.0062 0.0099
Plasmodium vivax hypothetical protein, conserved 0.0016 0.0016 0.0193
Plasmodium vivax hypothetical protein, conserved 0.0081 0.0592 0.7617
Schistosoma mansoni cpg binding protein 0.0034 0.0178 0.0288
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0026 0.0104 0.1735
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0124 0.0971 0.134
Plasmodium vivax hypothetical protein, conserved 0.0081 0.0592 0.7617
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0054 0.0073
Loa Loa (eye worm) glutathione reductase 0.004 0.0231 0.0442
Echinococcus granulosus voltage dependent calcium channel subunit 0.0839 0.7236 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0054 0.1664
Echinococcus multilocularis microtubule associated protein 2 0.0712 0.6127 0.8467
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0018 0.0041 0.004
Loa Loa (eye worm) hypothetical protein 0.0074 0.0531 0.1059
Echinococcus multilocularis jumonji domain containing 1A 0.0018 0.0038 0.0052
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0181 0.0248
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0075 0.0947
Leishmania major protein kinase, putative 0.0026 0.0104 0.1735
Schistosoma mansoni phosphatidylserine receptor 0.0018 0.0038 0.0061
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0025 0.01 0.1667
Echinococcus multilocularis short transient receptor potential channel 6 0.0072 0.051 0.0704
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0018 0.0038 0.0481
Leishmania major cytochrome p450-like protein 0.0018 0.0041 0.0674
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.002 0.0055 0.0074
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0018 0.0038 0.0631
Entamoeba histolytica hypothetical protein 0.0072 0.051 0.1598
Loa Loa (eye worm) hypothetical protein 0.0109 0.0832 0.168
Loa Loa (eye worm) hypothetical protein 0.0169 0.1361 0.2768
Trypanosoma cruzi UDP-galactopyranose mutase 0.0081 0.0592 1
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0018 0.0041 0.0043
Loa Loa (eye worm) jmjC domain-containing protein 0.0018 0.0038 0.0046
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0018 0.0041 0.0043
Schistosoma mansoni hypothetical protein 0.0569 0.4874 0.7955
Loa Loa (eye worm) hypothetical protein 0.0081 0.0592 0.1186
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0075 0.012
Brugia malayi glutathione reductase 0.004 0.0231 0.0471
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0054 0.0897
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.01 0.0409
Brugia malayi von Willebrand factor type A domain containing protein 0.0016 0.0016 0.0031
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.019 0.0783
Brugia malayi hypothetical protein 0.0021 0.0062 0.0125
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0102 0.077 1
Schistosoma mansoni microtubule-associated protein tau 0.0712 0.6127 1
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0054 0.0109
Schistosoma mansoni protein phosphatase 2C 0.0018 0.0038 0.0061
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0018 0.0041 0.0674
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0081 0.0592 0.0965
Loa Loa (eye worm) hypothetical protein 0.0034 0.0181 0.0339
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0181 0.0369
Schistosoma mansoni amine oxidase 0.0081 0.0592 0.0965
Giardia lamblia Kinase, NEK 0.0102 0.0777 1
Entamoeba histolytica hypothetical protein 0.0072 0.051 0.1598
Mycobacterium tuberculosis Probable dehydrogenase 0.0091 0.068 0.0731
Brugia malayi Zona pellucida-like domain containing protein 0.0016 0.0016 0.0031
Onchocerca volvulus 0.0035 0.0185 0.0841
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0035 0.0182 0.5592
Brugia malayi jmjC domain containing protein 0.007 0.0492 0.1007
Echinococcus multilocularis lysine specific demethylase 5A 0.0068 0.0476 0.0656
Trypanosoma cruzi cytochrome P450, putative 0.0018 0.0041 0.0674
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0072 0.051 0.0703
Trypanosoma cruzi trypanothione reductase, putative 0.004 0.0231 0.3882
Plasmodium vivax glutathione reductase, putative 0.004 0.0231 0.2957
Echinococcus granulosus jun protein 0.0101 0.0769 0.1061
Trichomonas vaginalis glutaminase, putative 0.0288 0.2408 1
Schistosoma mansoni tar DNA-binding protein 0.0063 0.043 0.07
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0025 0.01 0.0409
Echinococcus granulosus GPCR family 2 0.0034 0.0181 0.0248
Echinococcus multilocularis 0.0081 0.0592 0.0817
Brugia malayi beta-lactamase 0.0035 0.0185 0.0378
Echinococcus multilocularis protoporphyrinogen oxidase 0.0081 0.0592 0.0817
Mycobacterium ulcerans lipase LipD 0.0035 0.0185 0.0184
Schistosoma mansoni rab6-interacting 0.0021 0.0062 0.0099
Echinococcus granulosus single minded 2 0.0071 0.0507 0.0699
Mycobacterium ulcerans monoamine oxidase 0.0081 0.0592 0.0591
Brugia malayi bZIP transcription factor family protein 0.0101 0.0769 0.1576
Brugia malayi Pre-SET motif family protein 0.0032 0.0156 0.0318
Schistosoma mansoni hypothetical protein 0.0569 0.4874 0.7955
Loa Loa (eye worm) hypothetical protein 0.0035 0.0185 0.0349
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0102 0.077 0.0828
Plasmodium falciparum importin beta, putative 0.003 0.0145 0.1849
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0185 0.0378
Plasmodium falciparum NIMA related kinase 1 0.0102 0.0777 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0102 0.077 0.0828
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0368 0.3103 1
Toxoplasma gondii peptidylprolyl isomerase 0.0035 0.0182 0.2333
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0069 0.0488 0.0795
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0018 0.0041 0.0043
Brugia malayi Augmenter of liver regeneration 0.0039 0.0219 0.0447
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0185 0.5692
Echinococcus multilocularis muscleblind protein 0.0299 0.2505 0.3461
Brugia malayi hypothetical protein 0.0051 0.0326 0.0666
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0018 0.0041 0.004
Mycobacterium ulcerans dehydrogenase 0.0081 0.0592 0.0591
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0156 0.0253
Plasmodium falciparum protoporphyrinogen oxidase 0.0081 0.0592 0.7617
Leishmania major importin beta-1 subunit, putative 0.0025 0.0094 0.1579
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0091 0.068 0.0731
Loa Loa (eye worm) hypothetical protein 0.0299 0.2505 0.5123
Echinococcus granulosus indoleamine 23 dioxygenase 2 0.0569 0.4874 0.6735
Echinococcus granulosus voltage dependent calcium channel subunit 0.0381 0.3225 0.4456
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0101 0.0769 0.1061
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0099 0.0745 0.1214
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0054 0.1664
Schistosoma mansoni transient receptor potential channel 0.0072 0.051 0.0831
Plasmodium falciparum JmjC domain-containing protein, putative 0.0018 0.0038 0.0481
Trichomonas vaginalis STE family protein kinase 0.0102 0.0777 0.3224
Toxoplasma gondii NIMA-related protein kinase NIMA1 0.0102 0.0777 1
Brugia malayi glutaminase DH11.1 0.0288 0.2408 0.494
Mycobacterium ulcerans beta-lactamase 0.0035 0.0185 0.0184
Trypanosoma brucei PAB1-binding protein , putative 0.0051 0.0326 1
Loa Loa (eye worm) hypothetical protein 0.0109 0.0833 0.1682
Brugia malayi beta-lactamase family protein 0.0035 0.0185 0.0378
Brugia malayi hypothetical protein 0.008 0.0578 0.1184
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0054 0.1664
Leishmania major protein kinase, putative 0.0026 0.0104 0.1735
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0039 0.0219 0.3688
Entamoeba histolytica hypothetical protein 0.0072 0.051 0.1598
Loa Loa (eye worm) jmjC domain-containing protein 0.007 0.0492 0.0979
Brugia malayi jmjC domain containing protein 0.0018 0.0038 0.0077
Schistosoma mansoni amine oxidase 0.0081 0.0592 0.0965
Loa Loa (eye worm) hypothetical protein 0.0018 0.0038 0.0046
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0185 0.0198
Plasmodium falciparum thioredoxin reductase 0.004 0.0231 0.2957
Loa Loa (eye worm) indoleamine 2,3-dioxygenase 0.0569 0.4874 1
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0018 0.0041 0.0043
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0181 0.0248
Loa Loa (eye worm) hypothetical protein 0.0324 0.2722 0.557
Echinococcus granulosus lysine specific demethylase 6a 0.0018 0.0038 0.0052
Echinococcus granulosus thioredoxin glutathione reductase 0.0041 0.0235 0.0324
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0081 0.0592 0.7617
Echinococcus granulosus dna polymerase kappa 0.002 0.0054 0.0073
Schistosoma mansoni tar DNA-binding protein 0.0063 0.043 0.07
Echinococcus multilocularis phd:f box containing protein 0.0018 0.0038 0.0052
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0039 0.0219 0.3688
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0035 0.0182 0.0538
Echinococcus multilocularis 0.0018 0.0041 0.0055
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0368 0.3103 1
Brugia malayi von Willebrand factor type A domain containing protein 0.0016 0.0016 0.0031
Schistosoma mansoni hypothetical protein 0.0082 0.0602 0.0981
Trichomonas vaginalis rotamase, putative 0.0035 0.019 0.0783
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0185 0.0198
Echinococcus granulosus cpg binding protein 0.0034 0.0178 0.0244
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0094 0.0388
Loa Loa (eye worm) thioredoxin reductase 0.004 0.0231 0.0442
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.01 0.0409
Loa Loa (eye worm) hypothetical protein 0.0081 0.0592 0.1186
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0068 0.0476 0.0656
Schistosoma mansoni ran 0.0022 0.0075 0.012
Giardia lamblia Kinase, NEK 0.0102 0.0777 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0054 0.0078
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0018 0.0041 0.004
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.1154 1 1
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.008 0.0109
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0014 0.0001 0.0037
Brugia malayi Cytochrome P450 family protein 0.0018 0.0041 0.0082
Trichomonas vaginalis set domain proteins, putative 0.0245 0.203 0.8429
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0026 0.0104 0.1735
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0025 0.01 0.0172
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0025 0.01 0.0409
Plasmodium vivax thrombospondin-related anonymous protein 0.0016 0.0016 0.0193
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0018 0.0041 0.0043
Plasmodium vivax dynein-related AAA-type ATPase, putative 0.0016 0.0016 0.0193
Echinococcus granulosus aryl hydrocarbon receptor 0.0025 0.01 0.0136
Schistosoma mansoni transient receptor potential channel 4 0.0109 0.0833 0.1358
Schistosoma mansoni jun-related protein 0.0082 0.0602 0.0981
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0099 0.0745 0.1028
Loa Loa (eye worm) hypothetical protein 0.0099 0.0745 0.1499
Brugia malayi hypothetical protein 0.0081 0.0592 0.1213
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0018 0.0038 0.0061
Brugia malayi Transient-receptor-potential like protein 0.004 0.0234 0.0478
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0018 0.0041 0.004
Echinococcus multilocularis cpg binding protein 0.0034 0.0178 0.0244
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0018 0.0041 0.004
Loa Loa (eye worm) glutaminase 0.0288 0.2408 0.4924
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0323 0.271 0.5545
Loa Loa (eye worm) hypothetical protein 0.0021 0.0062 0.0094
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0025 0.01 0.1667
Loa Loa (eye worm) hypothetical protein 0.0025 0.01 0.0172
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0018 0.0041 0.004
Schistosoma mansoni cpg binding protein 0.0032 0.0162 0.0262
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.014 0.0192
Onchocerca volvulus 0.0025 0.01 0.0415
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0185 0.0766
Trichomonas vaginalis rotamase, putative 0.0035 0.0182 0.0752
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0018 0.0041 0.0674
Schistosoma mansoni jumonji domain containing protein 0.0018 0.0038 0.0061
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0018 0.0041 0.0674
Brugia malayi jmjC domain containing protein 0.0018 0.0038 0.0077
Loa Loa (eye worm) hypothetical protein 0.0018 0.0038 0.0046
Schistosoma mansoni tar DNA-binding protein 0.0063 0.043 0.07
Brugia malayi Immunoglobulin I-set domain containing protein 0.0016 0.0016 0.0031
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0185 0.0198
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0018 0.0041 0.0043
Brugia malayi Thioredoxin reductase 0.004 0.0231 0.0471
Toxoplasma gondii cytochrome p450 superfamily protein 0.0018 0.0041 0.0514
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0081 0.0592 0.0591
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0091 0.068 0.0731
Echinococcus granulosus phd:f box containing protein 0.0018 0.0038 0.0052
Schistosoma mansoni cpg binding protein 0.0034 0.0178 0.0288
Mycobacterium tuberculosis Conserved protein 0.0035 0.0185 0.0198
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0016 0.0016 0.0031
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0094 0.0388
Onchocerca volvulus 0.0032 0.0162 0.0723
Brugia malayi RNA, U transporter 1 0.0086 0.0633 0.1298
Echinococcus multilocularis voltage dependent calcium channel subunit 0.0381 0.3225 0.4456
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0054 0.0123
Mycobacterium tuberculosis Conserved protein 0.0035 0.0185 0.0198
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0018 0.0041 0.0043
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0054 0.1664
Echinococcus granulosus dnaJ subfamily B 0.0458 0.3898 0.5387
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0185 0.0766
Schistosoma mansoni glutaminase 0.0288 0.2408 0.393
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0062 0.0084
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0018 0.0041 0.0674
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0035 0.019 0.0387
Plasmodium vivax multidomain scavenger receptor, putative 0.0021 0.0062 0.0782
Echinococcus multilocularis dnaJ subfamily B 0.0458 0.3898 0.5387
Plasmodium falciparum glutathione reductase 0.004 0.0231 0.2957
Leishmania major trypanothione reductase 0.004 0.0231 0.3882
Schistosoma mansoni jumonji/arid domain-containing protein 0.007 0.0492 0.0801
Loa Loa (eye worm) hypothetical protein 0.003 0.0145 0.0265
Trichomonas vaginalis esterase, putative 0.0035 0.0185 0.0766
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0185 0.0766
Loa Loa (eye worm) hypothetical protein 0.0021 0.0062 0.0094
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0054 0.1664
Plasmodium vivax NIMA-related protein kinase (Pfnek-1), putative 0.0102 0.0777 1
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.1073 0.9287 1
Brugia malayi Pre-SET motif family protein 0.0216 0.177 0.363
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0025 0.01 0.0409

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -7.903 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the P388 Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -7.6 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -7.599 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -7.543 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -7.332 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -7.258 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -7.214 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -6.413 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.635 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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