Detailed information for compound 1654131

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 408.45 | Formula: C22H24N4O4
  • H donors: 2 H acceptors: 5 LogP: 4.09 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: C[C@H]1CCCC[C@H]1Oc1nc(N)c2c(n1)n(ccc2=O)Cc1ccc(cc1)C(=O)O
  • InChi: 1S/C22H24N4O4/c1-13-4-2-3-5-17(13)30-22-24-19(23)18-16(27)10-11-26(20(18)25-22)12-14-6-8-15(9-7-14)21(28)29/h6-11,13,17H,2-5,12H2,1H3,(H,28,29)(H2,23,24,25)/t13-,17+/m0/s1
  • InChiKey: UFTMWQKGUWOVBN-SUMWQHHRSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0028 0.022 0.0648
Trichomonas vaginalis set domain proteins, putative 0.0233 0.2558 0.8056
Schistosoma mansoni hypothetical protein 0.0208 0.2276 0.2983
Mycobacterium ulcerans glycyl-tRNA synthetase 0.0012 0.0029 0.0053
Brugia malayi glutathione reductase 0.0037 0.0319 0.1079
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0101 0.1045 0.1369
Trypanosoma brucei glucose transporter, putative 0.0065 0.0634 0.3403
Schistosoma mansoni serine/threonine protein kinase 0.0064 0.0624 0.0818
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0081 0.0819 0.2417
Echinococcus granulosus carbonic anhydrase 0.0081 0.0819 0.1074
Echinococcus multilocularis Threonyl tRNA synthetase, C 0.0012 0.0029 0.0038
Onchocerca volvulus 0.0029 0.023 0.0646
Trichomonas vaginalis sugar transporter, putative 0.0029 0.023 0.0685
Mycobacterium tuberculosis Probable dehydrogenase 0.0085 0.0863 0.3406
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0571 0.2236
Loa Loa (eye worm) hypothetical protein 0.0051 0.0476 0.1403
Trichomonas vaginalis ran, putative 0.0021 0.0136 0.0388
Loa Loa (eye worm) hypothetical protein 0.0015 0.0069 0.0205
Leishmania major hypothetical protein, conserved 0.001 0.0014 0.0073
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0029 0.023 0.1235
Entamoeba histolytica Ran family GTPase 0.0021 0.0136 0.034
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.0379 0.0497
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0064 0.0625 0.0625
Loa Loa (eye worm) glutathione reductase 0.0037 0.0319 0.0942
Onchocerca volvulus 0.0029 0.023 0.0646
Trichomonas vaginalis sugar transporter, putative 0.0029 0.023 0.0685
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.022 0.0332
Plasmodium vivax sugar transporter, putative 0.0029 0.023 0.023
Brugia malayi Cam kinase protein 1 0.0064 0.0624 0.2109
Giardia lamblia Lysyl-tRNA synthetase 0.0047 0.0427 0.1265
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0306 0.0927
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.004 0.0347 0.1336
Brugia malayi hypothetical protein 0.0015 0.0069 0.0234
Leishmania major lysyl-tRNA synthetase, putative 0.0047 0.0427 0.2291
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0009 0.0001 0.0007
Schistosoma mansoni protein kinase 0.0064 0.0624 0.0818
Plasmodium vivax hexose transporter 0.0208 0.2276 0.2276
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0064 0.0624 0.0818
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0094 0.0971 0.3839
Echinococcus granulosus solute carrier family 22 0.0029 0.023 0.0301
Entamoeba histolytica hypothetical protein 0.0023 0.0161 0.0418
Echinococcus granulosus peregrin 0.0032 0.026 0.0341
Echinococcus multilocularis solute carrier family 22 0.0029 0.023 0.0301
Loa Loa (eye worm) hypothetical protein 0.0047 0.0427 0.1259
Trichomonas vaginalis sugar transporter, putative 0.0029 0.023 0.0685
Treponema pallidum NADH oxidase 0.0013 0.0042 0.0041
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.1818 0.5715
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0013 0.0042 0.0097
Brugia malayi hypothetical protein 0.0029 0.023 0.0777
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0063 0.061 0.206
Brugia malayi PHD-finger family protein 0.0028 0.022 0.0742
Trichomonas vaginalis sugar transporter, putative 0.0029 0.023 0.0685
Loa Loa (eye worm) hypothetical protein 0.0012 0.0029 0.0086
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0028 0.022 0.0288
Echinococcus multilocularis glycyl tRNA synthetase 0.0012 0.0029 0.0038
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0319 0.1715
Brugia malayi hypothetical protein 0.012 0.1269 0.4286
Brugia malayi probable proline-trna synthetase - fission yeast, putative 0.0012 0.0029 0.0099
Schistosoma mansoni hypothetical protein 0.0009 0.0001 0.0002
Echinococcus multilocularis carbonic anhydrase 0.0081 0.0819 0.1074
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0064 0.0624 0.3353
Schistosoma mansoni carbonic anhydrase 0.0081 0.0819 0.1074
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0221 0.0653
Trichomonas vaginalis sugar transporter, putative 0.0029 0.023 0.0685
Trypanosoma cruzi hexose transporter 0.0065 0.0634 0.3403
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0136 0.0402
Echinococcus granulosus synaptic vesicle 2 protein 0.0029 0.023 0.0301
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0282 0.0953
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0136 0.0731
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0013 0.0042 0.0055
Brugia malayi major facilitator superfamily protein 0.0029 0.023 0.0777
Loa Loa (eye worm) hypothetical protein 0.0029 0.023 0.0679
Toxoplasma gondii sugar transporter ST2 0.0029 0.023 0.0347
Onchocerca volvulus 0.0029 0.023 0.0646
Trichomonas vaginalis esterase, putative 0.0036 0.0304 0.0919
Onchocerca volvulus 0.0029 0.023 0.0646
Onchocerca volvulus 0.0233 0.2558 1
Schistosoma mansoni hypothetical protein 0.0081 0.0819 0.1074
Onchocerca volvulus Huntingtin homolog 0.012 0.1269 0.4819
Schistosoma mansoni glycyl-tRNA synthetase 0.0012 0.0029 0.0038
Onchocerca volvulus 0.0029 0.023 0.0646
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0304 0.1632
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0218 0.0285
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0237 0.0311
Trichomonas vaginalis sugar transporter, putative 0.0029 0.023 0.0685
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0093 0.0958 0.1255
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0081 0.0819 0.2768
Echinococcus multilocularis cpg binding protein 0.003 0.024 0.0314
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0113 0.0382
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0144 0.154 0.2018
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0181 0.0181
Schistosoma mansoni hypothetical protein 0.0034 0.0282 0.037
Loa Loa (eye worm) hypothetical protein 0.0101 0.1045 0.3083
Loa Loa (eye worm) hypothetical protein 0.0081 0.0819 0.2417
Echinococcus granulosus solute carrier family 22 0.0029 0.023 0.0301
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0013 0.0042 0.0227
Plasmodium falciparum importin beta, putative 0.0029 0.0223 0.0223
Brugia malayi acetyltransferase, GNAT family protein 0.0144 0.154 0.5204
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0306 0.0927
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.023 0.0685
Plasmodium falciparum hexose transporter 0.0208 0.2276 0.2276
Loa Loa (eye worm) hypothetical protein 0.003 0.0237 0.07
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0571 0.0748
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0032 0.0263 0.1684
Brugia malayi RNA, U transporter 1 0.0081 0.0826 0.279
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0306 0.3389 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0237 0.0358
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0237 0.0311
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.022 0.0332
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0081 0.0821 0.252
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0013 0.0042 0.0227
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.004 0.0347 0.1336
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0094 0.0971 0.3839
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0063 0.061 0.1887
Schistosoma mansoni ran 0.0021 0.0136 0.0178
Schistosoma mansoni hypothetical protein 0.0306 0.3389 0.4441
Echinococcus granulosus General substrate transporter 0.0179 0.1941 0.2544
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0306 0.0401
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0013 0.0042 0.0227
Trichomonas vaginalis sugar transporter, putative 0.0029 0.023 0.0685
Loa Loa (eye worm) hypothetical protein 0.0064 0.0624 0.1842
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0304 0.0919
Trichomonas vaginalis sugar transporter, putative 0.0029 0.023 0.0685
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0029 0.023 0.0735
Mycobacterium leprae Probable lipase LipE 0.0036 0.0304 0.1958
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0304 0.1165
Onchocerca volvulus Putative transporter 0.0029 0.023 0.0646
Treponema pallidum fructose-bisphosphate aldolase 0.0287 0.3172 1
Echinococcus granulosus dnaJ subfamily B 0.0406 0.4537 0.5946
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.0319 0.0319
Echinococcus multilocularis General substrate transporter 0.0179 0.1941 0.2544
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.2826 0.8906
Leishmania major glucose transporter/membrane transporter D2, putative 0.0065 0.0634 0.3403
Loa Loa (eye worm) hypothetical protein 0.0029 0.023 0.0679
Echinococcus multilocularis lysyl tRNA synthetase 0.0047 0.0427 0.0559
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0015 0.0069 0.0234
Plasmodium vivax importin-beta 2, putative 0.0029 0.0223 0.0223
Entamoeba histolytica hypothetical protein 0.0047 0.0427 0.1265
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0064 0.0625 0.0943
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0013 0.0042 0.0097
Schistosoma mansoni glutaminase 0.0268 0.296 0.3878
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0304 0.0919
Trichomonas vaginalis sugar transporter, putative 0.0029 0.023 0.0685
Plasmodium falciparum phd finger protein, putative 0.0028 0.022 0.022
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0571 0.1892
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0237 0.0311
Echinococcus granulosus snurportin 1 0.0306 0.3389 0.4441
Trypanosoma brucei Aminoacyl-tRNA editing domain containing protein, putative 0.001 0.0014 0.0073
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0306 0.0462
Loa Loa (eye worm) PHD-finger family protein 0.0028 0.022 0.0648
Loa Loa (eye worm) hypothetical protein 0.0011 0.002 0.0059
Echinococcus multilocularis GPCR, family 2 0.0016 0.0074 0.0097
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0237 0.0311
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0307 0.0402
Onchocerca volvulus 0.0029 0.023 0.0646
Schistosoma mansoni hypothetical protein 0.0168 0.1818 0.2383
Trypanosoma cruzi hexose transporter, putative 0.0035 0.0299 0.1605
Trichomonas vaginalis sugar transporter, putative 0.0029 0.023 0.0685
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0064 0.0625 0.0625
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0306 0.1645
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.0379 0.0572
Trypanosoma brucei glucose transporter 1E 0.0065 0.0634 0.3403
Trichomonas vaginalis sugar transporter, putative 0.0029 0.023 0.0685
Brugia malayi hypothetical protein 0.0029 0.023 0.0777
Echinococcus granulosus histone acetyltransferase KAT2B 0.014 0.1494 0.1958
Trypanosoma brucei carbonic anhydrase-like protein 0.0172 0.1862 1
Brugia malayi Importin beta-1 subunit 0.0029 0.0223 0.0752
Onchocerca volvulus Huntingtin homolog 0.012 0.1269 0.4819
Schistosoma mansoni sodium/chloride dependent transporter 0.0015 0.0069 0.0091
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0074 0.0251
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.014 0.1496 1
Trichomonas vaginalis sugar transporter, putative 0.0029 0.023 0.0685
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0461 0.1558
Trichomonas vaginalis glucose transporter, putative 0.0065 0.0634 0.1963
Onchocerca volvulus 0.0029 0.023 0.0646
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0074 0.0097
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.0379 0.1157
Echinococcus granulosus glycyl tRNA synthetase 0.0012 0.0029 0.0038
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0094 0.0971 0.6456
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.125 0.3689
Giardia lamblia Sugar-proton symporter 0.0029 0.023 0.0639
Brugia malayi beta-lactamase family protein 0.0036 0.0304 0.1027
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0306 0.0882
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0304 0.0304
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0015 0.0069 0.0234
Giardia lamblia Fructose-bisphosphate aldolase 0.0287 0.3172 1
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.0379 0.0379
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.3172 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0042 0.0227
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0304 0.1958
Schistosoma mansoni lysyl-tRNA synthetase 0.0047 0.0427 0.0559
Schistosoma mansoni hypothetical protein 0.0011 0.0024 0.0031
Echinococcus granulosus carbonic anhydrase II 0.0172 0.1862 0.244
Mycobacterium ulcerans threonyl-tRNA synthetase 0.0012 0.0029 0.0053
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0015 0.0069 0.0091
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0013 0.0042 0.0055
Schistosoma mansoni glucose transporter 0.0029 0.023 0.0301
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0063 0.061 0.4021
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0011 0.0019 0.0024
Brugia malayi hypothetical protein 0.0029 0.023 0.0777
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0306 0.1645
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0017 0.0095 0.0124
Echinococcus multilocularis snurportin 1 0.0306 0.3389 0.4441
Trypanosoma brucei glucose transporter, putative 0.0065 0.0634 0.3403
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0029 0.023 0.0301
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0073 0.0728 0.3909
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0306 0.1645
Leishmania major protein kinase, putative 0.0064 0.0624 0.3353
Mycobacterium ulcerans beta-lactamase 0.0036 0.0304 0.0985
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0063 0.061 0.0799
Plasmodium falciparum carbonic anhydrase 0.0081 0.0819 0.0819
Loa Loa (eye worm) hypothetical protein 0.0029 0.023 0.0679
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0015 0.0069 0.0105
Trichomonas vaginalis sugar transporter, putative 0.0029 0.023 0.0685
Plasmodium vivax glycine--tRNA ligase, putative 0.0012 0.0029 0.0029
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0571 0.0748
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0047 0.0427 0.1402
Mycobacterium ulcerans integral membrane transport protein 0.0029 0.023 0.0735
Echinococcus multilocularis calcium dependent protein kinase 0.006 0.0579 0.0759
Mycobacterium ulcerans hypothetical protein 0.0036 0.0304 0.0985
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0015 0.0069 0.0091
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0304 0.1165
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0085 0.0863 0.3406
Loa Loa (eye worm) hypothetical protein 0.0029 0.023 0.0679
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0136 0.0178
Plasmodium vivax CDK-related protein kinase 6, putative 0.0884 1 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.023 0.0679
Toxoplasma gondii PHD-finger domain-containing protein 0.0009 0.0001 0.0002
Leishmania major glucose transporter, lmgt1 0.0065 0.0634 0.3403
Plasmodium vivax SET domain protein, putative 0.003 0.0237 0.0237
Plasmodium falciparum mitogen-activated protein kinase 2 0.0337 0.3742 0.3742
Trichomonas vaginalis myo-inositol transporter, putative 0.0029 0.023 0.0685
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0063 0.061 0.0799
Echinococcus granulosus jumonji domain containing protein 0.004 0.0347 0.0454
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.3172 1
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0161 0.0863
Schistosoma mansoni protein kinase 0.0064 0.0624 0.0818
Schistosoma mansoni sodium/chloride dependent transporter 0.0015 0.0069 0.0091
Trypanosoma brucei THT1 - hexose transporter, putative 0.0065 0.0634 0.3403
Trichomonas vaginalis sugar transporter, putative 0.0029 0.023 0.0685
Plasmodium falciparum calcium-dependent protein kinase 5 0.0064 0.0625 0.0625
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.1922 0.6043
Leishmania major GTP-binding protein, putative 0.0021 0.0136 0.0731
Trypanosoma brucei THT1 - hexose transporter, putative 0.0065 0.0634 0.3403
Loa Loa (eye worm) hypothetical protein 0.0081 0.0819 0.2417
Trypanosoma brucei glucose transporter, putative 0.0065 0.0634 0.3403
Loa Loa (eye worm) hypothetical protein 0.0036 0.0304 0.0897
Schistosoma mansoni ran 0.0021 0.0136 0.0178
Trichomonas vaginalis sugar transporter, putative 0.0065 0.0634 0.1963
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0208 0.2276 0.2983
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0015 0.0069 0.0091
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0013 0.0042 0.0115
Schistosoma mansoni cpg binding protein 0.003 0.024 0.0314
Loa Loa (eye worm) hypothetical protein 0.0081 0.0821 0.2423
Loa Loa (eye worm) hypothetical protein 0.0029 0.023 0.0679
Brugia malayi PHD-finger family protein 0.0011 0.002 0.0067
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0063 0.061 0.1847
Onchocerca volvulus 0.0036 0.0304 0.0943
Schistosoma mansoni inositol monophosphatase 0.0036 0.0306 0.0401
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0015 0.0069 0.0091
Plasmodium falciparum thioredoxin reductase 0.0013 0.0042 0.0042
Plasmodium falciparum calcium-dependent protein kinase 2 0.0064 0.0625 0.0625
Toxoplasma gondii lysine-tRNA ligase 0.0047 0.0427 0.0644
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0015 0.0069 0.0091
Trypanosoma cruzi hexose transporter, putative 0.0065 0.0634 0.3403
Trypanosoma brucei glucose transporter, putative 0.0065 0.0634 0.3403
Brugia malayi hypothetical protein 0.0016 0.008 0.027
Trichomonas vaginalis glucose transporter, putative 0.0029 0.023 0.0685
Treponema pallidum prolyl-tRNA synthetase 0.0022 0.0148 0.0377
Loa Loa (eye worm) hypothetical protein 0.0029 0.023 0.0679
Onchocerca volvulus 0.0029 0.023 0.0646
Schistosoma mansoni sodium-dependent amino acid transporter 0.0015 0.0069 0.0091
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0012 0.0029 0.0157
Mycobacterium ulcerans epoxide hydrolase EphA 0.0165 0.1781 0.5998
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0064 0.0625 0.0943
Plasmodium vivax hypothetical protein, conserved 0.0011 0.0021 0.0021
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0013 0.0042 0.0064
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0339 0.0339
Echinococcus granulosus PHD finger protein rhinoceros 0.0028 0.022 0.0288
Trypanosoma cruzi hexose transporter, putative 0.0065 0.0634 0.3403
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0161 0.0465
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.1818 0.5715
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0161 0.0465
Brugia malayi CXXC zinc finger family protein 0.0029 0.0221 0.0747
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0042 0.0227
Loa Loa (eye worm) hypothetical protein 0.0034 0.0282 0.0832
Echinococcus granulosus serotonin transporter 0.0015 0.0069 0.0091
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0013 0.0042 0.0042
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0136 0.046
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0042 0.0227
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0304 0.0897
Onchocerca volvulus 0.0029 0.023 0.0646
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0172 0.1862 0.6292
Loa Loa (eye worm) hypothetical protein 0.0029 0.023 0.0679
Echinococcus granulosus sodium and chloride dependent glycine 0.0015 0.0069 0.0091
Echinococcus multilocularis PHD finger protein rhinoceros 0.0028 0.022 0.0288
Leishmania major hypothetical protein, conserved 0.0029 0.023 0.1235
Trypanosoma brucei sugar transporter, putative 0.0029 0.023 0.1235
Schistosoma mansoni carbonic anhydrase-related 0.0081 0.0819 0.1074
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0042 0.0227
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0304 0.1632
Schistosoma mansoni hypothetical protein 0.0168 0.1818 0.2383
Brugia malayi beta-lactamase family protein 0.0036 0.0304 0.1027
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0015 0.0069 0.0234
Onchocerca volvulus 0.0029 0.023 0.0646
Loa Loa (eye worm) acetyltransferase 0.0144 0.154 0.4545
Toxoplasma gondii protein kinase, putative 0.0589 0.6622 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0038 0.0325 0.0426
Brugia malayi threonyl-tRNA synthetase, cytoplasmic 0.0012 0.0029 0.0099
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0634 0.1963
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0073 0.0728 0.3909
Chlamydia trachomatis proline--tRNA ligase 0.0022 0.0148 0.2978
Toxoplasma gondii glycyl-tRNA synthetase 0.0012 0.0029 0.0044
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0337 0.3742 0.3742
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0085 0.0863 0.5728
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0237 0.0311
Trichomonas vaginalis CAMK family protein kinase 0.0064 0.0624 0.1934
Leishmania major trypanothione reductase 0.0037 0.0319 0.1715
Loa Loa (eye worm) hypothetical protein 0.0036 0.0304 0.0897
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0064 0.0624 0.1842
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0181 0.0974
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0029 0.023 0.023
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0307 0.0402
Brugia malayi Inositol-1 0.0036 0.0306 0.1035
Echinococcus granulosus cpg binding protein 0.003 0.024 0.0314
Trichomonas vaginalis sugar transporter, putative 0.0029 0.023 0.0685
Plasmodium falciparum glutathione reductase 0.0037 0.0319 0.0319
Echinococcus granulosus Threonyl tRNA synthetase C 0.0012 0.0029 0.0038
Trichomonas vaginalis sugar transporter, putative 0.0029 0.023 0.0685
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0073 0.0728 0.3909
Mycobacterium tuberculosis Conserved protein 0.0036 0.0304 0.1165
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0073 0.0728 0.1099
Onchocerca volvulus Alhambra homolog 0.0028 0.022 0.0604
Plasmodium falciparum amino acid transporter, putative 0.0015 0.0069 0.0069
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0306 0.0993
Trichomonas vaginalis glutaminase, putative 0.0268 0.296 0.9329
Plasmodium falciparum lysine--tRNA ligase 0.0047 0.0427 0.0427
Mycobacterium tuberculosis Probable oxidoreductase 0.0094 0.0971 0.3839
Trichomonas vaginalis sugar transporter, putative 0.0029 0.023 0.0685
Echinococcus granulosus importin subunit beta 1 0.0029 0.0223 0.0292
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0013 0.0042 0.0055
Trichomonas vaginalis conserved hypothetical protein 0.0208 0.2276 0.7164
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.2826 0.8906
Brugia malayi hypothetical protein 0.0025 0.0181 0.0613
Plasmodium falciparum transporter, putative 0.0015 0.0069 0.0069
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0136 0.0178
Trichomonas vaginalis sugar transporter, putative 0.0029 0.023 0.0685
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0013 0.0042 0.0042
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0304 0.0985
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0304 0.1165
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0015 0.0069 0.0105
Echinococcus multilocularis solute carrier family 22 0.0029 0.023 0.0301
Chlamydia trachomatis lysine--tRNA ligase 0.0047 0.0427 1
Trichomonas vaginalis sugar transporter, putative 0.0029 0.023 0.0685
Brugia malayi lysyl-tRNA synthetase 0.0047 0.0427 0.1442
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0014 0.0073
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0172 0.1862 0.5495
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0013 0.0042 0.0097
Trichomonas vaginalis sugar transporter, putative 0.0029 0.023 0.0685
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0565 0.1668
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0081 0.0819 0.2768
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0136 0.0731
Leishmania major glucose transporter, lmgt2 0.0065 0.0634 0.3403
Echinococcus granulosus solute carrier family 22 0.0029 0.023 0.0301
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0172 0.1862 1
Mycobacterium ulcerans lipase LipD 0.0036 0.0304 0.0985
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0011 0.0019 0.0024
Echinococcus granulosus microtubule associated protein 2 0.0677 0.7631 1
Trichomonas vaginalis sugar transporter, putative 0.0029 0.023 0.0685
Entamoeba histolytica protein kinase, putative 0.0064 0.0624 0.1894
Brugia malayi Sugar transporter family protein 0.0208 0.2276 0.769
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.3172 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0069 0.0205
Schistosoma mansoni inositol monophosphatase 0.0036 0.0306 0.0401
Loa Loa (eye worm) sugar transporter 0.0208 0.2276 0.6716
Loa Loa (eye worm) major facilitator superfamily transporter 0.0029 0.023 0.0679
Onchocerca volvulus Glucosylceramidase homolog 0.0168 0.1818 0.7029
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0064 0.0624 0.0818
Loa Loa (eye worm) hypothetical protein 0.005 0.0461 0.1361
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0073 0.0728 0.3909
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0304 0.1165
Plasmodium falciparum proline--tRNA ligase 0.0073 0.0728 0.0728
Loa Loa (eye worm) hypothetical protein 0.0015 0.0069 0.0205
Leishmania major glucose transporter, lmgt3 0.0065 0.0634 0.3403
Trichomonas vaginalis sugar transporter, putative 0.0029 0.023 0.0685
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0047 0.0427 0.2787
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0029 0.023 0.0868
Trichomonas vaginalis sugar transporter, putative 0.0029 0.023 0.0685
Loa Loa (eye worm) histone methyltransferase 0.001 0.0008 0.0025
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0208 0.2276 0.2983
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0571 0.0862
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0013 0.0042 0.0227
Plasmodium falciparum glutathione reductase 0.0013 0.0042 0.0042
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0208 0.2276 0.2983
Trichomonas vaginalis glucose transporter, putative 0.0065 0.0634 0.1963
Giardia lamblia Prolyl-tRNA synthetase 0.0063 0.061 0.1847
Loa Loa (eye worm) hypothetical protein 0.0029 0.023 0.0679
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0009 0.0001 0.0007
Schistosoma mansoni sugar transporter 0.0029 0.023 0.0301
Echinococcus granulosus lysyl tRNA synthetase 0.0047 0.0427 0.0559
Toxoplasma gondii hypothetical protein 0.0015 0.0069 0.0105
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0257 0.2826 0.834
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0136 0.0206
Brugia malayi Major Facilitator Superfamily protein 0.0029 0.023 0.0777
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0085 0.0863 0.3406
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0029 0.023 0.0735
Trypanosoma brucei trypanothione reductase 0.0037 0.0319 0.1715
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0093 0.0958 0.1255
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0304 0.0919
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0014 0.0073
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0013 0.0042 0.0143
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0101 0.1045 0.1369
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.0009 0.0003 0.0014
Leishmania major carbonic anhydrase-like protein 0.0172 0.1862 1
Trypanosoma brucei glucose transporter, putative 0.0065 0.0634 0.3403
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0257 0.2826 0.9549
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0571 0.1892
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0304 0.0919
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0063 0.061 0.206
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0172 0.1862 0.244
Onchocerca volvulus 0.0029 0.023 0.0646
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0287 0.3172 1
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0073 0.0728 0.3909
Trichomonas vaginalis mercuric reductase, putative 0.0013 0.0042 0.0091
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0161 0.0465
Onchocerca volvulus 0.003 0.0237 0.0674
Plasmodium falciparum thioredoxin reductase 0.0037 0.0319 0.0319
Trypanosoma cruzi Aminoacyl-tRNA editing domain containing protein, putative 0.001 0.0014 0.0073
Schistosoma mansoni sugar transporter 0.0029 0.023 0.0301
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0064 0.0625 0.0943
Trichomonas vaginalis sugar transporter, putative 0.0029 0.023 0.0685
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0064 0.0624 0.0818
Brugia malayi Sugar transporter family protein 0.0029 0.023 0.0777
Plasmodium falciparum calcium-dependent protein kinase 1 0.0064 0.0625 0.0625
Schistosoma mansoni sugar transporter 0.0029 0.023 0.0301
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0136 0.0731
Schistosoma mansoni lysyl-tRNA synthetase 0.0047 0.0427 0.0559
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.014 0.1496 0.5947
Schistosoma mansoni carbonic anhydrase-related 0.0081 0.0819 0.1074
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0306 0.0927
Brugia malayi Pre-SET motif family protein 0.0205 0.2235 0.7553
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0461 0.1558
Trichomonas vaginalis sugar transporter, putative 0.0065 0.0634 0.1963
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.0565 0.0854
Onchocerca volvulus 0.0029 0.0221 0.061
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0319 0.0942
Echinococcus granulosus GPCR family 2 0.0016 0.0074 0.0097
Schistosoma mansoni hypothetical protein 0.0016 0.0074 0.0097
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0304 0.0398
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0064 0.0624 0.0818
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0013 0.0042 0.0042
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0571 0.1892
Trypanosoma brucei glycyl-tRNA synthetase, putative 0.0012 0.0029 0.0157
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0015 0.0069 0.0091
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0008 0.0011
Trichomonas vaginalis sugar transporter, putative 0.0029 0.023 0.0685
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.0307 0.0904
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0136 0.034
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0029 0.023 0.0868
Trypanosoma brucei glucose transporter, putative 0.0065 0.0634 0.3403
Loa Loa (eye worm) hypothetical protein 0.012 0.1269 0.3744
Loa Loa (eye worm) major facilitator superfamily transporter 0.0029 0.023 0.0679
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0347 0.0454
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0015 0.0069 0.0234
Toxoplasma gondii sugar transporter ST3 0.0029 0.023 0.0347
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0237 0.0311
Trichomonas vaginalis sugar transporter, putative 0.0029 0.023 0.0685
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0081 0.0819 0.2768
Brugia malayi AF-10 protein 0.0009 0.0001 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.023 0.0685
Trypanosoma cruzi hexose transporter, putative 0.0029 0.023 0.1235
Trichomonas vaginalis sugar transporter, putative 0.0029 0.023 0.0685
Trichomonas vaginalis sugar transporter, putative 0.0029 0.023 0.0685
Toxoplasma gondii NADPH-glutathione reductase 0.0013 0.0042 0.0064
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.1922 0.6043
Trypanosoma brucei glucose transporter 2A 0.0065 0.0634 0.3403
Loa Loa (eye worm) hypothetical protein 0.0063 0.061 0.1799
Toxoplasma gondii sugar transporter ST1 0.0029 0.023 0.0347
Mycobacterium tuberculosis Probable reductase 0.0085 0.0863 0.3406
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0223 0.1195
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0064 0.0625 0.0625
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0029 0.023 0.0301
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0172 0.1862 0.6292
Giardia lamblia NADH oxidase lateral transfer candidate 0.0013 0.0042 0.0041
Loa Loa (eye worm) hypothetical protein 0.0063 0.061 0.1799
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0081 0.0819 0.2768
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0172 0.1862 1
Trichomonas vaginalis sugar transporter, putative 0.0029 0.023 0.0685
Schistosoma mansoni hypothetical protein 0.0028 0.022 0.0288
Loa Loa (eye worm) hypothetical protein 0.0029 0.0223 0.0657
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0306 0.1645
Schistosoma mansoni protein kinase 0.0064 0.0624 0.0818
Echinococcus multilocularis synaptic vesicle 2 protein 0.0029 0.023 0.0301
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0208 0.2276 0.2983
Schistosoma mansoni glucose transport protein 0.0208 0.2276 0.2983
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0208 0.2276 0.2983
Echinococcus multilocularis microtubule associated protein 2 0.0677 0.7631 1
Echinococcus multilocularis dnaJ subfamily B 0.0406 0.4537 0.5946
Trypanosoma brucei threonyl-tRNA synthetase, putative 0.0012 0.0029 0.0157
Leishmania major hypothetical protein, conserved 0.0036 0.0304 0.1632
Loa Loa (eye worm) hypothetical protein 0.0049 0.0451 0.1332
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0013 0.0042 0.0042
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.2826 0.8906
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0634 0.1963
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0461 0.1361
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0024 0.0031
Loa Loa (eye worm) hypothetical protein 0.0036 0.0304 0.0897
Trichomonas vaginalis sugar transporter, putative 0.0029 0.023 0.0685
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.023 0.0685
Loa Loa (eye worm) norepinephrine transporter 0.0015 0.0069 0.0205
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0081 0.0819 0.2768
Loa Loa (eye worm) hypothetical protein 0.0015 0.0069 0.0205
Schistosoma mansoni sodium/chloride dependent transporter 0.0019 0.0115 0.0151
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0042 0.0227
Brugia malayi MH2 domain containing protein 0.0119 0.125 0.4224
Echinococcus multilocularis solute carrier family 22 0.0029 0.023 0.0301
Loa Loa (eye worm) threonyl-tRNA synthetase 0.0012 0.0029 0.0086
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0205 0.2235 0.6597
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.3172 1
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0172 0.1862 0.244
Brugia malayi jmjC domain containing protein 0.0036 0.0307 0.1036
Loa Loa (eye worm) hypothetical protein 0.0036 0.0304 0.0897
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.1818 0.5715
Leishmania major hypothetical protein, conserved 0.0025 0.0181 0.0974
Brugia malayi glutaminase DH11.1 0.0268 0.296 1
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0063 0.061 0.0799
Toxoplasma gondii hypothetical protein 0.0081 0.0819 0.1237
Brugia malayi beta-lactamase 0.0036 0.0304 0.1027
Loa Loa (eye worm) hypothetical protein 0.0029 0.023 0.0679
Loa Loa (eye worm) glutaminase 2 0.0268 0.296 0.8734
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0208 0.2276 0.2983
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0022 0.0148 0.0455
Loa Loa (eye worm) hypothetical protein 0.0029 0.023 0.0679
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0101 0.1045 0.1369
Brugia malayi Thioredoxin reductase 0.0037 0.0319 0.1079
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0223 0.0292
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0144 0.154 0.2018
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0306 1
Leishmania major threonyl-tRNA synthetase, putative 0.0012 0.0029 0.0157
Echinococcus multilocularis sodium and chloride dependent glycine 0.0015 0.0069 0.0091
Trypanosoma cruzi trypanothione reductase, putative 0.0013 0.0042 0.0227
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0015 0.0069 0.0205
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0181 0.0274
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.014 0.1496 0.5031
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0015 0.0069 0.101
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0304 0.0985
Toxoplasma gondii transporter, major facilitator family protein 0.0029 0.023 0.0347
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0304 0.1165
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0228 0.2506 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0069 0.0205
Schistosoma mansoni hypothetical protein 0.0406 0.4537 0.5946
Schistosoma mansoni importin beta-1 0.0029 0.0223 0.0292
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0013 0.0042 0.0227
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0571 0.3066
Schistosoma mansoni hypothetical protein 0.0016 0.0074 0.0097
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0042 0.0227
Loa Loa (eye worm) hypothetical protein 0.0015 0.0069 0.0205
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0009 0.0003 0.0011
Onchocerca volvulus 0.0029 0.023 0.0646
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0599 0.0785
Trypanosoma brucei THT1 - hexose transporter, putative 0.0065 0.0634 0.3403
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0015 0.0069 0.0091
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0047 0.0427 0.1402
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0074 0.0097
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0181 0.0974
Echinococcus multilocularis thioredoxin glutathione reductase 0.0038 0.0325 0.0426
Toxoplasma gondii thioredoxin reductase 0.0037 0.0319 0.0482
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0304 0.0398
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0101 0.1045 0.1369
Schistosoma mansoni glucose transport protein 0.0208 0.2276 0.2983
Schistosoma mansoni jumonji domain containing protein 0.0074 0.0739 0.0969
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0304 0.1632
Brugia malayi Pre-SET motif family protein 0.003 0.0237 0.0801
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0208 0.2276 0.2983
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0571 0.0748
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0026 0.0188 0.0556
Loa Loa (eye worm) inositol-1 0.0036 0.0306 0.0904
Loa Loa (eye worm) hypothetical protein 0.0016 0.0074 0.0219
Loa Loa (eye worm) carbonic anhydrase 3 0.0172 0.1862 0.5495
Mycobacterium tuberculosis Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase) 0.0165 0.1781 0.7091
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.0319 0.1227
Plasmodium vivax glutathione reductase, putative 0.0037 0.0319 0.0319
Plasmodium vivax proline--tRNA ligase, putative 0.0073 0.0728 0.0728
Brugia malayi major facilitator superfamily protein 0.0029 0.023 0.0777
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0013 0.0042 0.0327
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0304 0.1165
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0064 0.0624 0.0818
Echinococcus multilocularis carbonic anhydrase 0.0081 0.0819 0.1074
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0074 0.0097
Onchocerca volvulus 0.0036 0.0304 0.0943
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0306 0.0401
Schistosoma mansoni cpg binding protein 0.003 0.024 0.0314
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0024 0.0031
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0064 0.0624 0.0818
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0013 0.0042 0.0227
Plasmodium falciparum protein kinase 7 0.0589 0.6622 0.6622
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0029 0.023 0.7249
Loa Loa (eye worm) hypothetical protein 0.0036 0.0304 0.0897
Loa Loa (eye worm) hypothetical protein 0.0029 0.023 0.0679
Entamoeba histolytica protein kinase, putative 0.0064 0.0624 0.1894
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0047 0.0427 0.2291
Toxoplasma gondii hypothetical protein 0.0015 0.0069 0.0105
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0013 0.0042 0.0227
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0337 0.3742 0.5652
Plasmodium vivax hypothetical protein, conserved 0.0015 0.0069 0.0069
Loa Loa (eye worm) beta-lactamase 0.0036 0.0304 0.0897
Schistosoma mansoni sugar transporter 0.0029 0.023 0.0301
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0223 0.1195
Mycobacterium leprae Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) 0.0012 0.0029 0.0105
Loa Loa (eye worm) hypothetical protein 0.012 0.1269 0.3744
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0011 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0015 0.0069 0.0205
Echinococcus multilocularis lysine specific demethylase 5A 0.0034 0.0288 0.0377
Trichomonas vaginalis sugar transport protein, putative 0.0029 0.023 0.0685
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0181 0.0181
Plasmodium falciparum calcium-dependent protein kinase 4 0.0064 0.0625 0.0625
Loa Loa (eye worm) glutaminase 0.0268 0.296 0.8734
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0064 0.0624 0.0818
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0063 0.061 0.0799
Loa Loa (eye worm) serotonin transporter b 0.0015 0.0069 0.0205
Brugia malayi Sugar transporter family protein 0.0029 0.023 0.0777
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0208 0.2276 0.2983
Echinococcus multilocularis peregrin 0.0032 0.026 0.0341
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0013 0.0042 0.047
Trichomonas vaginalis sugar transporter, putative 0.0029 0.023 0.0685
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0015 0.0069 0.0205
Loa Loa (eye worm) hypothetical protein 0.0101 0.1045 0.3083
Loa Loa (eye worm) solute carrier family 6 member 4 0.0015 0.0069 0.0205
Echinococcus multilocularis geminin 0.0168 0.1818 0.2383
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0339 0.0985
Brugia malayi Bromodomain containing protein 0.0032 0.026 0.0878
Plasmodium vivax calcium-dependent protein kinase, putative 0.0064 0.0625 0.0625
Giardia lamblia Hexose transporter 0.0029 0.023 0.0639
Onchocerca volvulus 0.0029 0.023 0.0646
Trypanosoma cruzi Aminoacyl-tRNA editing domain containing protein, putative 0.001 0.0014 0.0073
Trypanosoma cruzi sugar transporter, putative 0.0029 0.023 0.1235
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0085 0.0863 0.3406
Onchocerca volvulus 0.0029 0.023 0.0646
Loa Loa (eye worm) hypothetical protein 0.0029 0.023 0.0679
Trichomonas vaginalis sugar transporter, putative 0.0029 0.023 0.0685
Plasmodium falciparum threonine--tRNA ligase 0.0012 0.0029 0.0029
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0041 0.0361 0.1101
Toxoplasma gondii facilitative glucose transporter GT1 0.0208 0.2276 0.3437
Schistosoma mansoni glucose transport protein 0.0208 0.2276 0.2983
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0339 0.0985
Loa Loa (eye worm) hypothetical protein 0.0015 0.0069 0.0205
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0304 0.1165
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0304 0.0398
Loa Loa (eye worm) hypothetical protein 0.0029 0.023 0.0679
Echinococcus multilocularis sodium and chloride dependent glycine 0.0015 0.0069 0.0091
Toxoplasma gondii ABC1 family protein 0.0036 0.0304 0.0459
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0064 0.0624 0.0818
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0101 0.1045 0.1369
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0015 0.0069 0.0091
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.1818 0.5715
Trypanosoma cruzi hexose transporter, putative 0.0065 0.0634 0.3403
Leishmania major hypothetical protein, conserved 0.001 0.0014 0.0073
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.0379 0.1157
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.3172 1
Leishmania major importin beta-1 subunit, putative 0.0023 0.0161 0.0863
Echinococcus granulosus calcium dependent protein kinase 0.006 0.0579 0.0759
Loa Loa (eye worm) sugar transporter 0.0029 0.023 0.0679
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.1818 0.5715
Loa Loa (eye worm) glycyl-tRNA synthetase 0.0012 0.0029 0.0086
Loa Loa (eye worm) hypothetical protein 0.0081 0.0819 0.2417
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.3172 1
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0136 0.0136
Treponema pallidum sodium- and chloride- dependent transporter 0.0015 0.0069 0.0128
Schistosoma mansoni hypothetical protein 0.0016 0.0074 0.0097
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0223 0.0336
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0237 0.0311
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0015 0.0069 0.0091
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0181 0.0181
Echinococcus granulosus geminin 0.0168 0.1818 0.2383
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.125 0.3689
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0074 0.0219
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0015 0.0069 0.0105
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0013 0.0042 0.0227
Schistosoma mansoni cpg binding protein 0.0029 0.0221 0.029
Echinococcus granulosus solute carrier family 22 0.0029 0.023 0.0301
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0304 0.1027
Mycobacterium tuberculosis Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) 0.0012 0.0029 0.0063
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0008 0.0011
Mycobacterium tuberculosis Conserved protein 0.0036 0.0304 0.1165
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0013 0.0042 0.0227
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0047 0.0427 0.1308
Trichomonas vaginalis sugar transporter, putative 0.0065 0.0634 0.1963
Brugia malayi glycyl-tRNA synthetase 0.0012 0.0029 0.0099
Plasmodium vivax amine transporter, putative 0.0015 0.0069 0.0069
Onchocerca volvulus 0.0029 0.023 0.0646
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.023 0.0685
Echinococcus multilocularis serotonin transporter 0.0015 0.0069 0.0091
Plasmodium vivax hypothetical protein, conserved 0.0028 0.022 0.022
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.2826 0.8906
Trypanosoma cruzi glucose transporter, putative 0.0029 0.023 0.1235
Loa Loa (eye worm) hypothetical protein 0.0029 0.023 0.0679
Trichomonas vaginalis glutathione reductase, putative 0.0013 0.0042 0.0091
Trypanosoma brucei glucose transporter, putative 0.0065 0.0634 0.3403
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0013 0.0042 0.0227
Mycobacterium ulcerans sugar transporter 0.0029 0.023 0.0735
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0571 0.0748
Schistosoma mansoni microtubule-associated protein tau 0.0677 0.7631 1
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0013 0.0042 0.047
Toxoplasma gondii YbaK/proline-tRNA ligase associated domain-containing protein 0.001 0.0014 0.0021
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0009 0.0003 0.0011
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0015 0.0069 0.0091
Mycobacterium ulcerans glutaminase 0.0268 0.296 1
Echinococcus multilocularis carbonic anhydrase II 0.0172 0.1862 0.244
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0047 0.0427 0.2291
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.3172 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0181 0.0535
Brugia malayi Major Facilitator Superfamily protein 0.0029 0.023 0.0777
Loa Loa (eye worm) hypothetical protein 0.0036 0.0304 0.0897
Echinococcus granulosus carbonic anhydrase 0.0081 0.0819 0.1074
Echinococcus granulosus Sugar transporter ERD6 protein 0.0029 0.023 0.0301
Trypanosoma brucei glucose transporter, putative 0.0065 0.0634 0.3403
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0081 0.0821 0.252
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0015 0.0069 0.0234
Onchocerca volvulus 0.0029 0.023 0.0646
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.023 0.0685
Brugia malayi jmjC domain containing protein 0.0093 0.0958 0.3236
Trichomonas vaginalis threonyl-tRNA synthetase, putative 0.0012 0.0029 0.0049
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0181 0.0974
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0015 0.0069 0.0091
Toxoplasma gondii threonyl-tRNA synthetase family protein 0.0012 0.0029 0.0044
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0287 0.3172 1
Echinococcus multilocularis carbonic anhydrase 0.0081 0.0819 0.1074
Plasmodium falciparum calcium-dependent protein kinase 3 0.0064 0.0625 0.0625
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0304 0.0919
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0064 0.0624 0.1842
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0009 0.0001 0.0002
Brugia malayi Major Facilitator Superfamily protein 0.0029 0.023 0.0777
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0263 0.1001
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0012 0.0029 0.0157
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0136 0.0136
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.1818 0.5715
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.0379 0.0572
Trichomonas vaginalis sugar transporter, putative 0.0029 0.023 0.0685
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0085 0.0863 0.3406
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0304 0.0398
Echinococcus granulosus lysine specific demethylase 5A 0.0036 0.0307 0.0402
Trichomonas vaginalis sugar transporter, putative 0.0029 0.023 0.0685
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.2826 0.8906
Plasmodium vivax threonine--tRNA ligase, putative 0.0012 0.0029 0.0029
Schistosoma mansoni carbonic anhydrase-related 0.0081 0.0819 0.1074
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.004 0.0347 0.2246
Leishmania major myo-inositol/proton symporter (MIT) 0.0029 0.023 0.1235
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.3172 1
Plasmodium vivax lysine--tRNA ligase, putative 0.0047 0.0427 0.0427
Echinococcus granulosus carbonic anhydrase 0.0081 0.0819 0.1074
Onchocerca volvulus 0.0036 0.0304 0.0943
Echinococcus multilocularis solute carrier family 22 0.0029 0.023 0.0301
Trichomonas vaginalis sugar transporter, putative 0.0029 0.023 0.0685
Echinococcus granulosus sodium and chloride dependent glycine 0.0015 0.0069 0.0091
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0064 0.0624 0.2109
Schistosoma mansoni hypothetical protein 0.0016 0.0074 0.0097
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0074 0.0097
Giardia lamblia PHD finger protein 15 0.0028 0.022 0.0606
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0074 0.0251
Mycobacterium tuberculosis Conserved protein 0.0036 0.0304 0.1165
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.1818 0.5715
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.2826 0.8906

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) Antibacterial activity against wild-type Escherichia coli ChEMBL. 22560470

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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