TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 348.195 | Formula: C15H14BrN3O2
H donors: 2 H acceptors: 1 LogP: 2.15 Rotable bonds: 1
Rule of 5 violations (Lipinski): 1
SMILES: Brc1ccc2c(c1)c1nc([nH]c(=O)c1o2)C1CCNCC1
InChi: 1S/C15H14BrN3O2/c16-9-1-2-11-10(7-9)12-13(21-11)15(20)19-14(18-12)8-3-5-17-6-4-8/h1-2,7-8,17H,3-6H2,(H,18,19,20)
InChiKey: GVUXAQWOKREQBF-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	casein kinase 2, beta polypeptide		References
Homo sapiens	Pim-1 proto-oncogene, serine/threonine kinase	Starlite/ChEMBL	References
Homo sapiens	cell division cycle 7	Starlite/ChEMBL	References
Homo sapiens	casein kinase 2, alpha 1 polypeptide		References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trichomonas vaginalis	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Schistosoma japonicum	ko:K03115 casein kinase 2, beta polypeptide, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Toxoplasma gondii	casein kinase ii regulatory subunit protein	Get druggable targets OG5_126846	All targets in OG5_126846
Plasmodium vivax	unspecified product	Get druggable targets OG5_126901	All targets in OG5_126901
Leishmania braziliensis	casein kinase II, putative	Get druggable targets OG5_126901	All targets in OG5_126901
Trichomonas vaginalis	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Loa Loa (eye worm)	CMGC/CK2 protein kinase	Get druggable targets OG5_126901	All targets in OG5_126901
Leishmania braziliensis	protein kinase ck2 regulatory subunit, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Candida albicans	Casein kinase II, regulatory (beta-prime) subunit	Get druggable targets OG5_126846	All targets in OG5_126846
Trichomonas vaginalis	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Leishmania infantum	protein kinase ck2 regulatory subunit, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Plasmodium vivax	casein kinase 2, alpha subunit, putative	Get druggable targets OG5_126901	All targets in OG5_126901
Trichomonas vaginalis	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Plasmodium berghei	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Plasmodium knowlesi	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Trichomonas vaginalis	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Plasmodium yoelii	casein kinase ii beta chain	Get druggable targets OG5_126846	All targets in OG5_126846
Trichomonas vaginalis	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Schistosoma japonicum	ko:K04702 proto-oncogene serine/threonine-protein kinase Pim-1, putative	Get druggable targets OG5_134863	All targets in OG5_134863
Trypanosoma congolense	Casein kinase II subunit beta, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Trypanosoma brucei	Casein kinase II	Get druggable targets OG5_126901	All targets in OG5_126901
Cryptosporidium parvum	casein kinase II, alpha subunit, putative	Get druggable targets OG5_126901	All targets in OG5_126901
Entamoeba histolytica	casein kinase, putative	Get druggable targets OG5_126901	All targets in OG5_126901
Trichomonas vaginalis	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Schistosoma japonicum	ko:K03115 casein kinase 2, beta polypeptide, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Candida albicans	protein serine/threonine kinase	Get druggable targets OG5_129189	All targets in OG5_129189
Theileria parva	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Trichomonas vaginalis	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Plasmodium knowlesi	casein kinase 2, alpha subunit, putative	Get druggable targets OG5_126901	All targets in OG5_126901
Trypanosoma congolense	casein kinase II, putative	Get druggable targets OG5_126901	All targets in OG5_126901
Echinococcus multilocularis	casein kinase ii subunit alpha	Get druggable targets OG5_126901	All targets in OG5_126901
Loa Loa (eye worm)	CAMK/PIM protein kinase	Get druggable targets OG5_134863	All targets in OG5_134863
Echinococcus multilocularis	casein kinase ii subunit beta	Get druggable targets OG5_126846	All targets in OG5_126846
Plasmodium falciparum	casein kinase 2, alpha subunit	Get druggable targets OG5_126901	All targets in OG5_126901
Trypanosoma cruzi	casein kinase II, putative	Get druggable targets OG5_126901	All targets in OG5_126901
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126901	All targets in OG5_126901
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_134863	All targets in OG5_134863
Schistosoma japonicum	ko:K02214 cell division control protein CDC7, putative	Get druggable targets OG5_129189	All targets in OG5_129189
Onchocerca volvulus	Serine\/threonine protein kinase homolog	Get druggable targets OG5_134863	All targets in OG5_134863
Leishmania mexicana	protein kinase ck2 regulatory subunit, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Leishmania donovani	casein kinase II, putative	Get druggable targets OG5_126901	All targets in OG5_126901
Trichomonas vaginalis	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_129189	All targets in OG5_129189
Onchocerca volvulus		Get druggable targets OG5_129189	All targets in OG5_129189
Plasmodium falciparum	casein kinase II beta chain	Get druggable targets OG5_126846	All targets in OG5_126846
Entamoeba histolytica	casein kinase II regulatory subunit family protein	Get druggable targets OG5_126846	All targets in OG5_126846
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_129189	All targets in OG5_129189
Candida albicans	Casein kinase II, regulatory (beta) subunit	Get druggable targets OG5_126846	All targets in OG5_126846
Plasmodium knowlesi	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Neospora caninum	YOR039Wp-like protein, related	Get druggable targets OG5_126846	All targets in OG5_126846
Entamoeba histolytica	casein kinase II regulatory subunit family protein	Get druggable targets OG5_126846	All targets in OG5_126846
Giardia lamblia	Kinase, CDC7	Get druggable targets OG5_129189	All targets in OG5_129189
Entamoeba histolytica	casein kinase II regulatory subunit family protein	Get druggable targets OG5_126846	All targets in OG5_126846
Theileria parva	casein kinase II, alpha chain	Get druggable targets OG5_126901	All targets in OG5_126901
Candida albicans	likely protein kinase similar to S. cerevisiae CKA1 (YIL035C) alpha subunit of protein kinase 2, aka casein kinase II	Get druggable targets OG5_126901	All targets in OG5_126901
Toxoplasma gondii	CMGC kinase, CK2 family	Get druggable targets OG5_126901	All targets in OG5_126901
Echinococcus granulosus	casein kinase ii subunit beta	Get druggable targets OG5_126846	All targets in OG5_126846
Candida albicans	Casein kinase II, regulatory (beta) subunit	Get druggable targets OG5_126846	All targets in OG5_126846
Plasmodium berghei	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Trypanosoma brucei	Casein kinase II subunit beta, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Leishmania donovani	Casein kinase II subunit beta, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Loa Loa (eye worm)	CAMK/PIM protein kinase	Get druggable targets OG5_134863	All targets in OG5_134863
Trichomonas vaginalis	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Cryptosporidium hominis	protein kinase domain	Get druggable targets OG5_126901	All targets in OG5_126901
Loa Loa (eye worm)	Csnk2b protein	Get druggable targets OG5_126846	All targets in OG5_126846
Candida albicans	Casein kinase II alpha' subunit	Get druggable targets OG5_126901	All targets in OG5_126901
Theileria parva	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Trypanosoma cruzi	Casein kinase II subunit beta, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Echinococcus granulosus	CDC7 cell division cycle 7	Get druggable targets OG5_129189	All targets in OG5_129189
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126901	All targets in OG5_126901
Cryptosporidium parvum	putative casein kinase II regulatory subunit; besthit Pf 23508244	Get druggable targets OG5_126846	All targets in OG5_126846
Candida albicans	Casein kinase II, regulatory (beta-prime) subunit	Get druggable targets OG5_126846	All targets in OG5_126846
Trichomonas vaginalis	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Trichomonas vaginalis	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_129189	All targets in OG5_129189
Leishmania major	casein kinase II, putative	Get druggable targets OG5_126901	All targets in OG5_126901
Echinococcus granulosus	proto oncogene serine:threonine protein kinase	Get druggable targets OG5_134863	All targets in OG5_134863
Giardia lamblia	Kinase, CMGC CK2	Get druggable targets OG5_126901	All targets in OG5_126901
Onchocerca volvulus		Get druggable targets OG5_129189	All targets in OG5_129189
Trichomonas vaginalis	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Brugia malayi	Csnk2b protein	Get druggable targets OG5_126846	All targets in OG5_126846
Brugia malayi	Serine/threonine-protein kinase Pim-3	Get druggable targets OG5_134863	All targets in OG5_134863
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126901	All targets in OG5_126901
Babesia bovis	casein kinase II beta 4 subunit, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Brugia malayi	Protein kinase domain containing protein	Get druggable targets OG5_134863	All targets in OG5_134863
Brugia malayi	Protein kinase domain containing protein	Get druggable targets OG5_129189	All targets in OG5_129189
Echinococcus granulosus	casein kinase ii subunit alpha	Get druggable targets OG5_126901	All targets in OG5_126901
Babesia bovis	protein kinase CK2 regulatory subunit CK2B1	Get druggable targets OG5_126846	All targets in OG5_126846
Onchocerca volvulus	Casein kinase II subunit beta homolog	Get druggable targets OG5_126846	All targets in OG5_126846
Plasmodium yoelii	Protein kinase domain	Get druggable targets OG5_126901	All targets in OG5_126901
Babesia bovis	casein kinase II, alpha chain (CK II)	Get druggable targets OG5_126901	All targets in OG5_126901
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_129189	All targets in OG5_129189
Plasmodium berghei	casein kinase 2, alpha subunit	Get druggable targets OG5_126901	All targets in OG5_126901
Trypanosoma brucei gambiense	casein kinase II, putative	Get druggable targets OG5_126901	All targets in OG5_126901
Cryptosporidium parvum	putative protein kinase CK2 regulatory subunit CK2B1	Get druggable targets OG5_126846	All targets in OG5_126846
Entamoeba histolytica	protein kinase domain containing protein	Get druggable targets OG5_126901	All targets in OG5_126901
Candida albicans	protein serine/threonine kinase	Get druggable targets OG5_129189	All targets in OG5_129189
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126901	All targets in OG5_126901
Giardia lamblia	Casein kinase II beta chain	Get druggable targets OG5_126846	All targets in OG5_126846
Brugia malayi	Casein kinase II, alpha chain	Get druggable targets OG5_126901	All targets in OG5_126901
Plasmodium yoelii	protein kinase Ck2-beta	Get druggable targets OG5_126846	All targets in OG5_126846
Trichomonas vaginalis	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Neospora caninum	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Echinococcus multilocularis	proto oncogene serine:threonine protein kinase	Get druggable targets OG5_134863	All targets in OG5_134863
Schistosoma mansoni	protein kinase	Get druggable targets OG5_126901	All targets in OG5_126901
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126901	All targets in OG5_126901
Echinococcus multilocularis	CDC7 cell division cycle 7	Get druggable targets OG5_129189	All targets in OG5_129189
Schistosoma japonicum	Casein kinase II subunit beta, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126901	All targets in OG5_126901
Neospora caninum	hypothetical protein	Get druggable targets OG5_126901	All targets in OG5_126901
Trypanosoma brucei gambiense	protein kinase ck2 regulatory subunit, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Cryptosporidium hominis	protein kinase Ck2-beta	Get druggable targets OG5_126846	All targets in OG5_126846
Loa Loa (eye worm)	CDC7 protein kinase	Get druggable targets OG5_129189	All targets in OG5_129189
Schistosoma japonicum	ko:K03097 casein kinase 2, alpha polypeptide, putative	Get druggable targets OG5_126901	All targets in OG5_126901
Schistosoma mansoni	casein kinase II beta subunit	Get druggable targets OG5_126846	All targets in OG5_126846
Plasmodium vivax	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Leishmania mexicana	casein kinase II, putative	Get druggable targets OG5_126901	All targets in OG5_126901
Onchocerca volvulus	Casein kinase II subunit beta homolog	Get druggable targets OG5_126846	All targets in OG5_126846
Candida albicans	Casein kinase II alpha' subunit	Get druggable targets OG5_126901	All targets in OG5_126901
Leishmania infantum	casein kinase II, putative	Get druggable targets OG5_126901	All targets in OG5_126901
Trypanosoma cruzi	Casein kinase II subunit beta, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Plasmodium vivax	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Trichomonas vaginalis	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Toxoplasma gondii	ck2 beta subunit	Get druggable targets OG5_126846	All targets in OG5_126846
Leishmania major	protein kinase ck2 regulatory subunit, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126901	All targets in OG5_126901
Plasmodium falciparum	casein kinase II beta chain	Get druggable targets OG5_126846	All targets in OG5_126846

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma cruzi	casein kinase II, alpha chain, putative	casein kinase 2, alpha 1 polypeptide	391 aa	316 aa	51.3 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma brucei	beta tubulin	0.0139	0.0632	0.2336
Echinococcus multilocularis	tubulin alpha 3 chain	0.0258	0.1246	0.1459
Trypanosoma brucei	zeta tubulin, putative	0.006	0.0227	0.0814
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0258	0.1246	0.1459
Trichomonas vaginalis	tubulin beta chain, putative	0.0139	0.0632	0.4885
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0198	0.0935	0.7269
Toxoplasma gondii	CMGC kinase, CK2 family	0.0082	0.0341	0.124
Trypanosoma cruzi	UDP-galactopyranose mutase	0.002	0.0021	0.004
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0044	0.0144	0.1052
Trypanosoma cruzi	epsilon tubulin, putative	0.0139	0.0632	0.2336
Trichomonas vaginalis	tubulin epsilon chain, putative	0.006	0.0227	0.1703
Schistosoma mansoni	hypothetical protein	0.0032	0.0079	0.0205
Trichomonas vaginalis	CMGC family protein kinase	0.0082	0.0341	0.2594
Brugia malayi	glutaminase DH11.1	0.0265	0.1282	0.177
Echinococcus granulosus	tubulin subunit beta	0.0139	0.0632	0.1853
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0025	0.0045	0.1164
Leishmania major	beta tubulin	0.0139	0.0632	0.2336
Trypanosoma cruzi	alpha tubulin, putative	0.0258	0.1246	0.4643
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0021	0.0025	0.0044
Brugia malayi	Tubulin alpha chain	0.0258	0.1246	0.1719
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0013	0.0015
Trypanosoma brucei	alpha tubulin	0.0258	0.1246	0.4643
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0139	0.0631	0.1851
Echinococcus granulosus	Niemann Pick C1 protein	0.0104	0.0451	0.1313
Echinococcus multilocularis	Tubulin beta 2C chain	0.0139	0.0632	0.0734
Trypanosoma brucei	alpha tubulin	0.0258	0.1246	0.4643
Leishmania major	delta tubulin, putative	0.006	0.0227	0.0814
Echinococcus multilocularis	musashi	0.0026	0.0051	0.0048
Schistosoma mansoni	hypothetical protein	0.0068	0.0268	0.0769
Trypanosoma brucei	beta tubulin	0.0139	0.0632	0.2336
Schistosoma mansoni	hypothetical protein	0.0032	0.0079	0.0205
Echinococcus multilocularis		0.002	0.0021	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0146	0.0912
Schistosoma mansoni	tubulin subunit gamma	0.0139	0.0632	0.1853
Entamoeba histolytica	tubulin alpha-1 chain	0.0258	0.1246	1
Trichomonas vaginalis	tubulin beta chain, putative	0.0258	0.1246	0.9711
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0046	0.0132
Plasmodium falciparum	tubulin gamma chain	0.0139	0.0632	0.2336
Schistosoma mansoni	transient receptor potential channel 4	0.0097	0.0414	0.1203
Entamoeba histolytica	acyl-coA synthetase, putative	0.0025	0.0045	0.0281
Echinococcus multilocularis	tubulin alpha 1C chain	0.0258	0.1246	0.1459
Leishmania major	UDP-galactopyranose mutase	0.002	0.0021	0.004
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0025	0.0045	0.0249
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0032	0.0079	0.0081
Echinococcus granulosus	alpha tubulin	0.0258	0.1246	0.3683
Mycobacterium ulcerans	oxidoreductase	0.002	0.0021	0.0077
Echinococcus granulosus	Tubulin alpha 1 chain	0.0258	0.1246	0.3683
Mycobacterium ulcerans	monoamine oxidase	0.002	0.0021	0.0077
Echinococcus granulosus	tubulin subunit TubB	0.0258	0.1246	0.3683
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0045	0.0146	0.0912
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0032	0.0079	0.0205
Echinococcus granulosus	tubulin beta 4A class IVa	0.0139	0.0632	0.1853
Trypanosoma brucei	tubulin gamma chain	0.0139	0.0632	0.2336
Echinococcus granulosus	proto oncogene serine:threonine protein kinase	0.0194	0.0914	0.2692
Mycobacterium tuberculosis	Possible oxidoreductase	0.002	0.0021	0.0107
Entamoeba histolytica	casein kinase II regulatory subunit family protein	0.0044	0.0144	0.1084
Echinococcus multilocularis	expressed conserved protein	0.0097	0.0418	0.0482
Brugia malayi	Calcitonin receptor-like protein seb-1	0.01	0.0431	0.0595
Leishmania major	beta tubulin	0.0139	0.0632	0.2336
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0051	0.0275
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0047	0.0158	0.0217
Entamoeba histolytica	hypothetical protein	0.0038	0.0112	0.082
Leishmania major	hypothetical protein, conserved	0.0025	0.0046	0.0132
Schistosoma mansoni	tubulin subunit beta	0.0139	0.0632	0.1853
Echinococcus granulosus	tubulin epsilon chain	0.0139	0.0632	0.1853
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0032	0.0079	0.011
Plasmodium vivax	casein kinase II beta chain, putative	0.0044	0.0144	0.0503
Trichomonas vaginalis	CMGC family protein kinase	0.0082	0.0341	0.2594
Brugia malayi	Tubulin gamma chain	0.0139	0.0632	0.0872
Echinococcus granulosus	Tubulin alpha 1 chain	0.0258	0.1246	0.3683
Trichomonas vaginalis	importin beta-1, putative	0.0023	0.0036	0.0204
Brugia malayi	hypothetical protein	0.0025	0.0046	0.0063
Trypanosoma cruzi	Casein kinase II subunit beta, putative	0.0044	0.0144	0.0503
Loa Loa (eye worm)	tubulin alpha chain	0.0258	0.1246	0.8323
Schistosoma mansoni	hypothetical protein	0.0047	0.0158	0.0438
Leishmania major	alpha tubulin	0.0258	0.1246	0.4643
Leishmania major	telomerase reverse transcriptase, putative	0.0535	0.2671	1
Leishmania major	beta tubulin	0.0139	0.0632	0.2336
Echinococcus granulosus	tubulin alpha 3 chain	0.0258	0.1246	0.3683
Brugia malayi	AMP-binding enzyme family protein	0.0025	0.0045	0.0062
Brugia malayi	Tubulin alpha-2 chain	0.0258	0.1246	0.1719
Echinococcus multilocularis	sterol regulatory element binding protein	0.0045	0.0146	0.016
Echinococcus granulosus	TRP transient receptor potential channel	0.0036	0.0102	0.0272
Leishmania major	4-coumarate:coa ligase-like protein	0.0025	0.0045	0.013
Loa Loa (eye worm)	hypothetical protein	0.0179	0.0841	0.5596
Schistosoma mansoni	alpha tubulin	0.0258	0.1246	0.3683
Trypanosoma cruzi	beta tubulin, putative	0.0139	0.0632	0.2336
Echinococcus granulosus	tubulin alpha 1C chain	0.0258	0.1246	0.3683
Trichomonas vaginalis	CMGC family protein kinase	0.007	0.0277	0.2091
Trichomonas vaginalis	CMGC family protein kinase	0.0082	0.0341	0.2594
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0139	0.0632	0.4885
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0025	0.0045	0.0293
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0306	0.1494	1
Onchocerca volvulus	Serine\/threonine protein kinase homolog	0.0194	0.0914	0.0894
Brugia malayi	Tubulin alpha-2 chain	0.0258	0.1246	0.1719
Schistosoma mansoni	tubulin subunit alpha	0.006	0.0227	0.0646
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0139	0.0631	0.0734
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0025	0.0045	0.0249
Leishmania major	beta tubulin	0.0139	0.0632	0.2336
Echinococcus granulosus	tubulin alpha chain	0.0258	0.1246	0.3683
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0044	0.0144	0.1052
Echinococcus multilocularis	tubulin alpha chain	0.0258	0.1246	0.1459
Echinococcus multilocularis	tubulin alpha chain	0.0258	0.1246	0.1459
Plasmodium falciparum	tubulin epsilon chain, putative	0.0139	0.0632	0.2336
Loa Loa (eye worm)	tubulin alpha-2 chain	0.0258	0.1246	0.8323
Schistosoma mansoni	tar DNA-binding protein	0.0129	0.0579	0.1695
Echinococcus granulosus	lamin	0.0026	0.0051	0.0122
Loa Loa (eye worm)	tubulin gamma chain	0.0139	0.0632	0.4187
Leishmania major	alpha tubulin	0.0258	0.1246	0.4643
Brugia malayi	tubulin alpha-2 chain	0.0258	0.1246	0.1719
Echinococcus granulosus	transient receptor potential ion channel A	0.0093	0.0398	0.1154
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0025	0.0045	0.1164
Schistosoma mansoni	hypothetical protein	0.0043	0.0138	0.0379
Plasmodium falciparum	telomerase reverse transcriptase	0.0535	0.2671	1
Echinococcus multilocularis	casein kinase ii subunit beta	0.0044	0.0144	0.0158
Loa Loa (eye worm)	alpha-tubulin	0.0258	0.1246	0.8323
Trypanosoma brucei	beta tubulin	0.0139	0.0632	0.2336
Trypanosoma brucei	epsilon tubulin	0.0139	0.0632	0.2336
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0046	0.0238
Plasmodium vivax	ataxin-2 like protein, putative	0.0025	0.0046	0.0132
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0019	0.0013	0.0041
Toxoplasma gondii	beta-1 tubulin, putative	0.0139	0.0632	0.2336
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0139	0.0632	0.4885
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.0289	0.1403	1
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0025	0.0045	0.0281
Toxoplasma gondii	histone lysine-specific demethylase	0.002	0.0021	0.004
Brugia malayi	alpha-tubulin	0.0258	0.1246	0.1719
Brugia malayi	Intermediate filament tail domain containing protein	0.0026	0.0051	0.0071
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0036	0.0204
Trypanosoma cruzi	telomerase reverse transcriptase, putative	0.0535	0.2671	1
Toxoplasma gondii	beta tubulin	0.0139	0.0632	0.2336
Schistosoma mansoni	tubulin subunit delta	0.006	0.0227	0.0646
Toxoplasma gondii	LsmAD domain-containing protein	0.0025	0.0046	0.0132
Trypanosoma cruzi	casein kinase II, putative	0.0082	0.0341	0.124
Trichomonas vaginalis	tubulin beta chain, putative	0.0258	0.1246	0.9711
Mycobacterium ulcerans	hypothetical protein	0.0154	0.0711	0.5033
Echinococcus granulosus	transient receptor potential gamma protein	0.0097	0.0414	0.1203
Echinococcus granulosus	tubulin alpha chain	0.0258	0.1246	0.3683
Echinococcus granulosus	tubulin alpha chain	0.0258	0.1246	0.3683
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0021	0.0025	0.0056
Schistosoma mansoni	amine oxidase	0.002	0.0021	0.0032
Schistosoma mansoni	tubulin subunit beta	0.0139	0.0632	0.1853
Entamoeba histolytica	tubulin family protein	0.0139	0.0632	0.5031
Brugia malayi	RNA, U transporter 1	0.0082	0.0337	0.0465
Leishmania major	beta tubulin	0.0139	0.0632	0.2336
Echinococcus granulosus	snurportin 1	0.0306	0.1494	0.4425
Giardia lamblia	Casein kinase II beta chain	0.0044	0.0144	0.0503
Echinococcus granulosus	tubulin gamma 1 chain	0.0139	0.0632	0.1853
Loa Loa (eye worm)	tubulin beta-4 chain	0.0139	0.0632	0.4187
Echinococcus multilocularis	tubulin alpha 3 chain	0.0258	0.1246	0.1459
Loa Loa (eye worm)	hypothetical protein	0.002	0.0021	0.0072
Giardia lamblia	Kinase, CDC7	0.007	0.0277	0.1
Brugia malayi	Latrophilin receptor protein 2	0.0032	0.0079	0.011
Entamoeba histolytica	hypothetical protein	0.0038	0.0112	0.082
Brugia malayi	hypothetical protein	0.0038	0.0112	0.0154
Echinococcus multilocularis	peroxisome assembly protein 26	0.0258	0.1246	0.1459
Trichomonas vaginalis	tubulin gamma chain, putative	0.0139	0.0632	0.4885
Plasmodium vivax	hypothetical protein, conserved	0.002	0.0021	0.004
Plasmodium falciparum	lysine-specific histone demethylase 1, putative	0.002	0.0021	0.004
Echinococcus multilocularis	short transient receptor potential channel 6	0.0064	0.0246	0.0278
Schistosoma mansoni	alpha tubulin	0.0258	0.1246	0.3683
Toxoplasma gondii	alpha-tubulin I, putative	0.0258	0.1246	0.4643
Echinococcus multilocularis	protein patched	0.0045	0.0146	0.016
Echinococcus granulosus	casein kinase ii subunit beta	0.0044	0.0144	0.0399
Plasmodium vivax	tubulin gamma chain, putative	0.0139	0.0632	0.2336
Echinococcus multilocularis	beta tubulin	0.0139	0.0632	0.0734
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0079	0.0464
Loa Loa (eye worm)	CAMK/PIM protein kinase	0.0194	0.0914	0.6085
Trichomonas vaginalis	glutaminase, putative	0.0265	0.1282	1
Trichomonas vaginalis	conserved hypothetical protein	0.0045	0.0146	0.1064
Loa Loa (eye worm)	tubulin beta-1 chain	0.0139	0.0632	0.4187
Brugia malayi	Serine/threonine-protein kinase Pim-3	0.0194	0.0914	0.1261
Plasmodium vivax	tubulin epsilon chain, putative	0.0139	0.0632	0.2336
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.006	0.0227	0.0814
Plasmodium falciparum	tubulin delta chain, putative	0.006	0.0227	0.0814
Brugia malayi	Tubulin beta-1 chain	0.0139	0.0632	0.0872
Mycobacterium ulcerans	acyl-CoA synthetase	0.0025	0.0045	0.0249
Trypanosoma brucei	tubulin delta chain	0.006	0.0227	0.0814
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0032	0.0079	0.0081
Echinococcus multilocularis	importin subunit beta 1	0.0029	0.0064	0.0064
Loa Loa (eye worm)	beta-tubulin	0.0139	0.0632	0.4187
Loa Loa (eye worm)	tubulin alpha 2	0.0198	0.0935	0.623
Leishmania major	alpha tubulin	0.0258	0.1246	0.4643
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0139	0.0631	0.0734
Brugia malayi	Casein kinase II, alpha chain	0.0082	0.0341	0.047
Leishmania major	alpha tubulin	0.0258	0.1246	0.4643
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0044	0.0144	0.1052
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0102	0.0614
Echinococcus multilocularis	tubulin alpha 1C chain	0.0258	0.1246	0.1459
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0044	0.0144	0.1052
Echinococcus multilocularis	tubulin subunit TubB	0.0258	0.1246	0.1459
Echinococcus granulosus	Tubulin alpha 1 chain	0.0258	0.1246	0.3683
Mycobacterium tuberculosis	Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO)	0.0268	0.1299	1
Schistosoma mansoni	hypothetical protein	0.0038	0.0112	0.0302
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0139	0.0631	0.0871
Echinococcus multilocularis	snurportin 1	0.0306	0.1494	0.1753
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0139	0.0631	0.2332
Loa Loa (eye worm)	alpha-tubulin isotype 2	0.0198	0.0935	0.623
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0451	0.2967
Leishmania major	alpha tubulin	0.0258	0.1246	0.4643
Echinococcus multilocularis	Tubulin beta 2C chain	0.0139	0.0632	0.0734
Loa Loa (eye worm)	hypothetical protein	0.0229	0.1098	0.7328
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0293	0.1426	0.532
Trichomonas vaginalis	tubulin, putative	0.0079	0.0321	0.2443
Entamoeba histolytica	hypothetical protein	0.0038	0.0112	0.082
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0154	0.0711	0.5453
Leishmania major	beta tubulin	0.0139	0.0632	0.2336
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0044	0.0144	0.1052
Trichomonas vaginalis	tubulin alpha chain, putative	0.0079	0.0321	0.2443
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0021	0.0025	0.0056
Schistosoma mansoni	microtubule-associated protein tau	0.0669	0.3364	1
Schistosoma mansoni	Protoporphyrinogen oxidase chloroplast/mitochondrial precursor	0.002	0.0021	0.0032
Plasmodium falciparum	alpha tubulin 2	0.0258	0.1246	0.4643
Brugia malayi	Tubulin beta chain	0.0079	0.0321	0.0443
Onchocerca volvulus		0.0079	0.0321	0.0301
Schistosoma mansoni	lamin	0.0026	0.0051	0.0122
Trichomonas vaginalis	tubulin beta chain, putative	0.0258	0.1246	0.9711
Echinococcus multilocularis	GPCR, family 2	0.0032	0.0079	0.0081
Schistosoma mansoni	tubulin subunit beta	0.0139	0.0632	0.1853
Giardia lamblia	Beta tubulin	0.0139	0.0632	0.2336
Plasmodium falciparum	casein kinase II beta chain	0.0044	0.0144	0.0503
Echinococcus granulosus	Tubulin beta 2C chain	0.0139	0.0632	0.1853
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0045	0.0234
Loa Loa (eye worm)	alpha-tubulin	0.0258	0.1246	0.8323
Echinococcus granulosus	lysine specific histone demethylase 1A	0.002	0.0021	0.0032
Loa Loa (eye worm)	tubulin alpha 2	0.0119	0.053	0.3503
Brugia malayi	Importin beta-1 subunit	0.0029	0.0064	0.0089
Schistosoma mansoni	protein kinase	0.0082	0.0341	0.0984
Schistosoma mansoni	hypothetical protein	0.0043	0.0138	0.0379
Trichomonas vaginalis	tubulin alpha chain, putative	0.0139	0.0632	0.4885
Schistosoma mansoni	alpha tubulin	0.0258	0.1246	0.3683
Echinococcus multilocularis	tubulin gamma 1 chain	0.0139	0.0632	0.0734
Echinococcus granulosus	lamin dm0	0.0026	0.0051	0.0122
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0414	0.272
Brugia malayi	hypothetical protein	0.0229	0.1098	0.1515
Trypanosoma cruzi	zeta tubulin, putative	0.006	0.0227	0.0814
Plasmodium vivax	telomerase reverse transcriptase, putative	0.0535	0.2671	1
Echinococcus granulosus	survival motor neuron protein 1	0.0229	0.1098	0.3243
Echinococcus multilocularis	tubulin alpha chain	0.0258	0.1246	0.1459
Schistosoma mansoni	lamin	0.0026	0.0051	0.0122
Entamoeba histolytica	casein kinase II regulatory subunit family protein	0.0044	0.0144	0.1084
Brugia malayi	Csnk2b protein	0.0044	0.0144	0.0199
Onchocerca volvulus		0.0047	0.0158	0.0137
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0021	0.0025	0.0056
Echinococcus granulosus	Tubulin beta 2C chain	0.0139	0.0632	0.1853
Trichomonas vaginalis	tubulin, putative	0.006	0.0227	0.1703
Schistosoma mansoni	patched 1	0.0045	0.0146	0.0403
Echinococcus multilocularis	casein kinase ii subunit alpha	0.0082	0.0341	0.039
Entamoeba histolytica	casein kinase II regulatory subunit family protein	0.0044	0.0144	0.1084
Echinococcus multilocularis	tar DNA binding protein	0.0129	0.0579	0.0672
Trypanosoma brucei	zeta tubulin	0.006	0.0227	0.0814
Plasmodium vivax	tubulin beta chain, putative	0.0139	0.0632	0.2336
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0041	0.0129	0.0444
Mycobacterium ulcerans	cell division protein FtsZ	0.006	0.0227	0.1555
Onchocerca volvulus	Casein kinase II subunit beta homolog	0.0044	0.0144	0.0123
Loa Loa (eye worm)	glutaminase 2	0.0265	0.1282	0.8571
Trypanosoma cruzi	UDP-galactopyranose mutase	0.002	0.0021	0.004
Leishmania major	alpha tubulin	0.0258	0.1246	0.4643
Echinococcus granulosus	tubulin alpha 3 chain	0.0258	0.1246	0.3683
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0021	0.0025	0.0056
Echinococcus multilocularis	Tubulin beta 2C chain	0.0139	0.0632	0.0734
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0044	0.0144	0.1052
Brugia malayi	amine oxidase, flavin-containing family protein	0.002	0.0021	0.0029
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.005	0.0175	0.0619
Trypanosoma brucei	beta tubulin	0.0139	0.0632	0.2336
Toxoplasma gondii	hypothetical protein	0.0047	0.016	0.0562
Trypanosoma brucei	alpha tubulin, putative	0.0079	0.0321	0.1168
Brugia malayi	AMP-binding enzyme family protein	0.0025	0.0045	0.0062
Leishmania major	beta tubulin	0.0139	0.0632	0.2336
Brugia malayi	AMP-binding enzyme family protein	0.0025	0.0045	0.0062
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0044	0.0144	0.1052
Plasmodium vivax	tubulin alpha chain, putative	0.0258	0.1246	0.4643
Echinococcus multilocularis	microtubule associated protein 2	0.0669	0.3364	0.3963
Trichomonas vaginalis	tubulin beta-1 chain, putative	0.006	0.0227	0.1703
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0046	0.0132
Brugia malayi	latrophilin 2 splice variant baaae	0.0068	0.0268	0.0371
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0021	0.0025	0.0056
Leishmania major	casein kinase II, putative	0.0082	0.0341	0.124
Schistosoma mansoni	hypothetical protein	0.0032	0.0079	0.0205
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.01	0.0431	0.2836
Echinococcus multilocularis	Tubulin beta 2C chain	0.0139	0.0632	0.0734
Echinococcus granulosus	tubulin beta 1 chain	0.0139	0.0632	0.1853
Echinococcus granulosus	tubulin alpha 1C chain	0.0258	0.1246	0.3683
Schistosoma mansoni	casein kinase II beta subunit	0.0044	0.0144	0.0399
Plasmodium vivax	casein kinase II beta chain, putative	0.0044	0.0144	0.0503
Echinococcus granulosus	peroxisome assembly protein 26	0.0258	0.1246	0.3683
Echinococcus multilocularis	protein dispatched 1	0.0051	0.0178	0.0198
Plasmodium vivax	casein kinase 2, alpha subunit, putative	0.0082	0.0341	0.124
Trichomonas vaginalis	CMGC family protein kinase	0.007	0.0277	0.2091
Leishmania major	alpha tubulin	0.0258	0.1246	0.4643
Echinococcus granulosus	Niemann Pick C1 protein	0.0148	0.068	0.1997
Mycobacterium ulcerans	acyl-CoA synthetase	0.0025	0.0045	0.0249
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0025	0.0045	0.0281
Schistosoma mansoni	tubulin subunit beta	0.0139	0.0632	0.1853
Echinococcus granulosus	importin subunit beta 1	0.0029	0.0064	0.0161
Echinococcus granulosus	sterol regulatory element binding protein	0.0045	0.0146	0.0403
Loa Loa (eye worm)	tubulin alpha 2	0.0198	0.0935	0.623
Plasmodium vivax	hypothetical protein, conserved	0.002	0.0021	0.004
Mycobacterium leprae	cell division protein FtsZ	0.006	0.0227	1
Schistosoma mansoni	tar DNA-binding protein	0.0129	0.0579	0.1695
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0021	0.0025	0.0056
Brugia malayi	beta-tubulin, identical	0.0139	0.0632	0.0872
Entamoeba histolytica	Ran family GTPase	0.0021	0.0025	0.012
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0104	0.0451	0.3565
Trypanosoma cruzi	zeta tubulin, putative	0.006	0.0227	0.0814
Schistosoma mansoni	tubulin subunit alpha	0.0258	0.1246	0.3683
Leishmania major	4-coumarate:coa ligase-like protein	0.0025	0.0045	0.013
Loa Loa (eye worm)	CMGC/CK2 protein kinase	0.0082	0.0341	0.2224
Trypanosoma brucei	epsilon tubulin	0.0139	0.0632	0.2336
Echinococcus multilocularis	hypothetical protein	0.0258	0.1246	0.1459
Loa Loa (eye worm)	RNA binding protein	0.0129	0.0579	0.3831
Leishmania major	alpha tubulin	0.0258	0.1246	0.4643
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0258	0.1246	0.9711
Giardia lamblia	Alpha-tubulin	0.0258	0.1246	0.4643
Trypanosoma brucei	alpha tubulin	0.0258	0.1246	0.4643
Plasmodium vivax	tubulin alpha chain, putative	0.0258	0.1246	0.4643
Leishmania major	alpha tubulin	0.0258	0.1246	0.4643
Leishmania major	beta tubulin	0.0139	0.0632	0.2336
Trypanosoma cruzi	tubulin gamma chain	0.0139	0.0632	0.2336
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0139	0.0631	0.4184
Loa Loa (eye worm)	hypothetical protein	0.002	0.0021	0.0072
Schistosoma mansoni	tar DNA-binding protein	0.0129	0.0579	0.1695
Loa Loa (eye worm)	TAR-binding protein	0.0129	0.0579	0.3831
Brugia malayi	Tubulin alpha chain	0.006	0.0227	0.0314
Loa Loa (eye worm)	tubulin beta-2A chain	0.0139	0.0632	0.4187
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0044	0.0144	0.1052
Loa Loa (eye worm)	tubulin alpha-3 chain	0.0179	0.0841	0.5596
Loa Loa (eye worm)	CAMK/PIM protein kinase	0.0194	0.0914	0.6085
Plasmodium falciparum	importin beta, putative	0.0029	0.0064	0.0202
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0258	0.1246	0.9711
Schistosoma mansoni	hypothetical protein	0.0306	0.1494	0.4425
Mycobacterium ulcerans	acyl-CoA synthetase	0.0025	0.0045	0.0249
Trypanosoma brucei	alpha tubulin	0.0258	0.1246	0.4643
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0041	0.0129	0.0444
Plasmodium vivax	acyl-CoA synthetase, putative	0.0019	0.0013	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0013	0.0015
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0139	0.0631	0.2332
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.1662	0.8474	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0025	0.0045	0.0293
Brugia malayi	hypothetical protein	0.002	0.0021	0.0029
Entamoeba histolytica	protein kinase domain containing protein	0.0082	0.0341	0.2672
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0268	0.1738
Brugia malayi	Telomerase reverse transcriptase	0.1423	0.7246	1
Leishmania major	GTP-binding protein, putative	0.0021	0.0025	0.0056
Toxoplasma gondii	beta-tubulin, putative	0.0139	0.0632	0.2336
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0044	0.0144	0.1052
Echinococcus multilocularis	tubulin alpha	0.0139	0.0632	0.0734
Loa Loa (eye worm)	Csnk2b protein	0.0044	0.0144	0.0902
Echinococcus multilocularis	lamin	0.0026	0.0051	0.0048
Trichomonas vaginalis	tubulin, putative	0.0139	0.0632	0.4885
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0139	0.0631	0.1851
Echinococcus granulosus	short transient receptor potential channel 6	0.0064	0.0246	0.0701
Leishmania major	beta tubulin	0.0139	0.0632	0.2336
Brugia malayi	RNA recognition motif domain containing protein	0.0129	0.0579	0.0799
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0139	0.0631	0.1851
Brugia malayi	SWIRM domain containing protein	0.002	0.0021	0.0029
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0293	0.1426	0.532
Plasmodium falciparum	acyl-CoA synthetase	0.0019	0.0013	0.0008
Leishmania major	4-coumarate:coa ligase-like protein	0.0025	0.0045	0.013
Brugia malayi	Protein kinase domain containing protein	0.0194	0.0914	0.1261
Loa Loa (eye worm)	glutaminase	0.0265	0.1282	0.8571
Loa Loa (eye worm)	intermediate filament protein	0.0026	0.0051	0.0275
Echinococcus multilocularis	short transient receptor potential channel 6	0.0064	0.0246	0.0278
Loa Loa (eye worm)	BEN-1 protein	0.0139	0.0632	0.4187
Leishmania major	beta tubulin	0.0139	0.0632	0.2336
Trichomonas vaginalis	ran, putative	0.0021	0.0025	0.0117
Leishmania major	mitochondrial DNA polymerase beta	0.0293	0.1426	0.532
Schistosoma mansoni	transient receptor potential channel	0.0097	0.0414	0.1203
Schistosoma mansoni	hypothetical protein	0.0032	0.0079	0.0205
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0139	0.0631	0.1851
Schistosoma mansoni	tar DNA-binding protein	0.0129	0.0579	0.1695
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0258	0.1246	0.1459
Loa Loa (eye worm)	hypothetical protein	0.01	0.0431	0.2836
Treponema pallidum	cell division protein FtsZ	0.006	0.0227	1
Trichomonas vaginalis	CMGC family protein kinase	0.0082	0.0341	0.2594
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0045	0.0234
Trypanosoma brucei	beta tubulin	0.0139	0.0632	0.2336
Schistosoma mansoni	hypothetical protein	0.0043	0.0138	0.0379
Leishmania major	beta tubulin	0.0139	0.0632	0.2336
Leishmania major	alpha tubulin	0.0258	0.1246	0.4643
Giardia lamblia	Delta tubulin	0.006	0.0227	0.0814
Echinococcus multilocularis	tubulin beta 1 chain	0.0139	0.0632	0.0734
Echinococcus multilocularis	Tubulin beta 2C chain	0.0139	0.0632	0.0734
Schistosoma mansoni	ran	0.0021	0.0025	0.0044
Onchocerca volvulus		0.0026	0.0051	0.003
Schistosoma mansoni	intermediate filament proteins	0.0026	0.0051	0.0122
Schistosoma mansoni	tubulin subunit alpha	0.0258	0.1246	0.3683
Echinococcus multilocularis	transient receptor potential ion channel A	0.0093	0.0398	0.0457
Leishmania major	beta tubulin	0.0139	0.0632	0.2336
Schistosoma mansoni	amine oxidase	0.002	0.0021	0.0032
Trichomonas vaginalis	tubulin gamma chain, putative	0.0139	0.0632	0.4885
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0229	0.1473
Toxoplasma gondii	HEAT repeat-containing protein	0.0029	0.0064	0.0202
Toxoplasma gondii	alpha tubulin TUBA1	0.0258	0.1246	0.4643
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0045	0.0234
Echinococcus multilocularis	Niemann Pick C1 protein	0.0104	0.0451	0.052
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0179	0.0841	0.6529
Echinococcus multilocularis	tubulin epsilon chain	0.0139	0.0632	0.0734
Toxoplasma gondii	RNA-directed DNA polymerase	0.0535	0.2671	1
Echinococcus granulosus	CDC7 cell division cycle 7	0.007	0.0277	0.0793
Trichomonas vaginalis	CMGC family protein kinase	0.0082	0.0341	0.2594
Echinococcus multilocularis	survival motor neuron protein 1	0.0229	0.1098	0.1285
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0197	0.126
Trichomonas vaginalis	tubulin beta chain, putative	0.0258	0.1246	0.9711
Entamoeba histolytica	tubulin family protein	0.0139	0.0632	0.5031
Echinococcus granulosus	short transient receptor potential channel 6	0.0064	0.0246	0.0701
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0139	0.0632	0.2336
Loa Loa (eye worm)	BEN-1 protein	0.0139	0.0632	0.4187
Echinococcus granulosus	beta tubulin	0.0139	0.0632	0.1853
Loa Loa (eye worm)	CDC7 protein kinase	0.007	0.0277	0.1792
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0139	0.0631	0.1851
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0139	0.0631	0.2332
Chlamydia trachomatis	protoporphyrinogen oxidase	0.002	0.0021	1
Trypanosoma brucei	Casein kinase II subunit beta, putative	0.0044	0.0144	0.0503
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0023	0.0036	0.0097
Trypanosoma cruzi	telomerase reverse transcriptase, putative	0.0535	0.2671	1
Leishmania major	beta tubulin	0.0139	0.0632	0.2336
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0018	0.0011	0.0024
Trichomonas vaginalis	CMGC family protein kinase	0.0082	0.0341	0.2594
Brugia malayi	Protein kinase domain containing protein	0.007	0.0277	0.0382
Plasmodium falciparum	casein kinase II beta chain	0.0044	0.0144	0.0503
Leishmania major	beta tubulin	0.0139	0.0632	0.2336
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0258	0.1246	0.1459
Echinococcus multilocularis	TRP (transient receptor potential) channel	0.0036	0.0102	0.0108
Echinococcus granulosus	tubulin delta chain	0.006	0.0227	0.0646
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0025	0.0045	0.0249
Brugia malayi	RNA binding protein	0.0129	0.0579	0.0799
Brugia malayi	Cell division protein ftsZ	0.006	0.0227	0.0314
Leishmania major	beta tubulin	0.0139	0.0632	0.2336
Brugia malayi	tubulin alpha chain - mouse	0.0258	0.1246	0.1719
Trypanosoma brucei	telomerase reverse transcriptase	0.0535	0.2671	1
Trypanosoma brucei	Casein kinase II	0.0082	0.0341	0.124
Echinococcus multilocularis	tubulin delta chain	0.006	0.0227	0.0256
Trichomonas vaginalis	tubulin beta chain, putative	0.0079	0.0321	0.2443
Echinococcus granulosus	tubulin alpha chain	0.0258	0.1246	0.3683
Brugia malayi	CHE-14 protein	0.0045	0.0146	0.0201
Mycobacterium ulcerans	glutaminase	0.0265	0.1282	0.9132
Schistosoma mansoni	tubulin subunit beta	0.0139	0.0632	0.1853
Toxoplasma gondii	casein kinase ii regulatory subunit protein	0.0044	0.0144	0.0503
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0021	0.0025	0.01
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0041	0.0129	0.0444
Schistosoma mansoni	serine/threonine protein kinase	0.007	0.0277	0.0793
Plasmodium falciparum	protoporphyrinogen oxidase	0.002	0.0021	0.004
Toxoplasma gondii	histone lysine-specific demethylase LSD1/BHC110/KDMA1A	0.002	0.0021	0.004
Onchocerca volvulus		0.007	0.0277	0.0256
Trichomonas vaginalis	tubulin gamma chain, putative	0.0139	0.0632	0.4885
Echinococcus multilocularis	transient receptor potential gamma protein	0.0097	0.0414	0.0477
Echinococcus multilocularis	lysine specific histone demethylase 1A	0.002	0.0021	0.0013
Mycobacterium tuberculosis	Cell division protein FtsZ	0.006	0.0227	0.1702
Onchocerca volvulus	Casein kinase II subunit beta homolog	0.0044	0.0144	0.0123
Mycobacterium ulcerans	protoporphyrinogen oxidase	0.002	0.0021	0.0077
Plasmodium vivax	unspecified product	0.0082	0.0341	0.124
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0013	0.0015
Trichomonas vaginalis	conserved hypothetical protein	0.006	0.0227	0.1703
Plasmodium vivax	lysine-specific histone demethylase 1, putative	0.002	0.0021	0.004
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0064	0.0363
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0026	0.0051	0.0275
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0044	0.0144	0.1052
Trypanosoma brucei	importin beta-1 subunit, putative	0.0029	0.0064	0.0202
Onchocerca volvulus		0.0026	0.0051	0.003
Trichomonas vaginalis	CMGC family protein kinase	0.0082	0.0341	0.2594
Schistosoma mansoni	transcription factor LCR-F1	0.0038	0.0112	0.0302
Trypanosoma cruzi	tubulin delta chain	0.006	0.0227	0.0814
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0085	0.0502
Mycobacterium tuberculosis	Conserved hypothetical protein	0.002	0.0021	0.0107
Brugia malayi	Tubulin beta chain	0.006	0.0227	0.0314
Schistosoma mansoni	tubulin subunit alpha	0.0258	0.1246	0.3683
Schistosoma mansoni	Lysine-specific histone demethylase 1	0.002	0.0021	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0013	0.0015
Giardia lamblia	Gamma tubulin	0.0139	0.0632	0.2336
Loa Loa (eye worm)	hypothetical protein	0.002	0.0021	0.0072
Echinococcus granulosus	tubulin alpha	0.0139	0.0632	0.1853
Trypanosoma brucei	epsilon tubulin	0.0139	0.0632	0.2336
Brugia malayi	exodeoxyribonuclease III family protein	0.0018	0.0011	0.0015
Trichomonas vaginalis	tubulin alpha chain, putative	0.0079	0.0321	0.2443
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0021	0.0025	0.0056
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0293	0.1426	0.532
Trichomonas vaginalis	tubulin alpha chain, putative	0.0139	0.0632	0.4885
Echinococcus multilocularis	tubulin, beta 4A class IVa	0.0139	0.0632	0.0734
Schistosoma mansoni	ran	0.0021	0.0025	0.0044
Trypanosoma cruzi	tubulin delta chain	0.006	0.0227	0.0814
Trichomonas vaginalis	CMGC family protein kinase	0.007	0.0277	0.2091
Echinococcus granulosus	tar DNA binding protein	0.0129	0.0579	0.1695
Loa Loa (eye worm)	hypothetical protein	0.002	0.0021	0.0072
Trypanosoma brucei	importin beta-1 subunit, putative	0.0029	0.0064	0.0202
Entamoeba histolytica	hypothetical protein	0.0023	0.0036	0.021
Echinococcus multilocularis	tubulin subunit beta	0.0139	0.0632	0.0734
Schistosoma mansoni	tubulin subunit beta	0.0139	0.0632	0.1853
Echinococcus granulosus	expressed conserved protein	0.0097	0.0418	0.1216
Echinococcus granulosus	Tubulin beta 2C chain	0.0139	0.0632	0.1853
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0021	0.0025	0.0018
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0038	0.0112	0.012
Trichomonas vaginalis	conserved hypothetical protein	0.006	0.0227	0.1703
Schistosoma mansoni	glutaminase	0.0265	0.1282	0.3792
Loa Loa (eye worm)	tubulin alpha chain	0.0258	0.1246	0.8323
Leishmania major	alpha tubulin	0.0258	0.1246	0.4643
Echinococcus granulosus	casein kinase ii subunit alpha	0.0082	0.0341	0.0984
Loa Loa (eye worm)	hypothetical protein	0.002	0.0021	0.0072
Entamoeba histolytica	tubulin alpha chain, putative	0.0258	0.1246	1
Echinococcus granulosus	Protein patched homolog 1	0.0045	0.0146	0.0403
Schistosoma mansoni	hypothetical protein	0.0043	0.0138	0.0379
Echinococcus granulosus	microtubule associated protein 2	0.0669	0.3364	1
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0044	0.0144	0.1052
Giardia lamblia	Beta tubulin	0.0139	0.0632	0.2336
Loa Loa (eye worm)	hypothetical protein	0.0198	0.0935	0.623
Onchocerca volvulus		0.007	0.0277	0.0256
Giardia lamblia	Alpha-tubulin	0.0258	0.1246	0.4643
Brugia malayi	Niemann-Pick C1 protein precursor	0.0104	0.0451	0.0622
Loa Loa (eye worm)	hypothetical protein	0.0258	0.1246	0.8323
Trypanosoma brucei	PAB1-binding protein , putative	0.0025	0.0046	0.0132
Brugia malayi	intermediate filament protein	0.0026	0.0051	0.0071
Leishmania major	importin beta-1 subunit, putative	0.0023	0.0036	0.0097
Echinococcus granulosus	Tubulin beta 2C chain	0.0139	0.0632	0.1853
Plasmodium vivax	importin-beta 2, putative	0.0029	0.0064	0.0202
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0013	0.0015
Echinococcus multilocularis	protoporphyrinogen oxidase	0.002	0.0021	0.0013
Wolbachia endosymbiont of Brugia malayi	cell division protein FtsZ	0.006	0.0227	1
Schistosoma mansoni	tubulin subunit epsilon	0.0139	0.0632	0.1853
Echinococcus multilocularis	lamin dm0	0.0026	0.0051	0.0048
Echinococcus multilocularis	tubulin alpha chain	0.0258	0.1246	0.1459
Plasmodium falciparum	casein kinase 2, alpha subunit	0.0082	0.0341	0.124
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0049	0.0258
Entamoeba histolytica	hypothetical protein	0.0038	0.0112	0.082
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0044	0.0144	0.1052
Schistosoma mansoni	tubulin subunit beta	0.006	0.0227	0.0646
Echinococcus granulosus	intermediate filament protein	0.0026	0.0051	0.0122
Echinococcus granulosus	Tubulin beta 2C chain	0.0139	0.0632	0.1853
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0025	0.0045	0.0249
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0044	0.0144	0.1052
Brugia malayi	TAR-binding protein	0.0129	0.0579	0.0799
Echinococcus granulosus	beta tubulin	0.0139	0.0632	0.1853
Entamoeba histolytica	tubulin gamma chain	0.0139	0.0632	0.5031
Plasmodium falciparum	tubulin beta chain	0.0139	0.0632	0.2336
Trichomonas vaginalis	tubulin alpha chain, putative	0.0079	0.0321	0.2443
Leishmania major	beta tubulin	0.0139	0.0632	0.2336
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0036	0.0204
Echinococcus multilocularis	Niemann Pick C1 protein	0.0148	0.068	0.0791
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0032	0.0079	0.0464
Echinococcus multilocularis	proto oncogene serine:threonine protein kinase	0.0194	0.0914	0.1067
Loa Loa (eye worm)	tubulin beta chain	0.0139	0.0632	0.4187
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0032	0.0079	0.0205
Echinococcus granulosus	GPCR family 2	0.0032	0.0079	0.0205
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0079	0.0321	0.2443
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.0289	0.1403	1
Trichomonas vaginalis	tubulin, putative	0.0079	0.0321	0.2443
Trichomonas vaginalis	tubulin gamma chain, putative	0.006	0.0227	0.1703
Trypanosoma cruzi	epsilon tubulin, putative	0.0139	0.0632	0.2336
Plasmodium falciparum	alpha tubulin 1	0.0258	0.1246	0.4643
Giardia lamblia	Telomerase catalytic subunit	0.0535	0.2671	1
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0038	0.0112	0.0302
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0105	0.0459	0.1338
Schistosoma mansoni	serine/threonine protein kinase	0.0194	0.0914	0.2692
Leishmania major	epsilon tubulin, putative	0.0139	0.0632	0.2336
Trichomonas vaginalis	tubulin beta chain, putative	0.0258	0.1246	0.9711
Mycobacterium ulcerans	dehydrogenase	0.002	0.0021	0.0077
Echinococcus granulosus	tubulin alpha chain	0.0258	0.1246	0.3683
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.002	0.0021	0.004
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0021	0.0025	0.0035
Loa Loa (eye worm)	tubulin beta chain	0.006	0.0227	0.146
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0044	0.0144	0.1052
Schistosoma mansoni	transient receptor potential channel	0.0064	0.0246	0.0701
Leishmania major	zeta tubulin, putative	0.006	0.0227	0.0814
Loa Loa (eye worm)	hypothetical protein	0.002	0.0021	0.0072
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0258	0.1246	0.9711
Schistosoma mansoni	survival motor neuron protein	0.0047	0.0158	0.0438
Echinococcus multilocularis	beta tubulin	0.0139	0.0632	0.0734
Giardia lamblia	Epsilon tubulin	0.006	0.0227	0.0814
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0046	0.0132
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0019	0.0013	0.0016
Mycobacterium ulcerans	hypothetical protein	0.0025	0.0045	0.0249
Onchocerca volvulus		0.0025	0.0045	0.0024
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0041	0.0129	0.0444
Trichomonas vaginalis	tubulin beta chain, putative	0.0258	0.1246	0.9711
Giardia lamblia	Beta tubulin	0.0139	0.0632	0.2336
Toxoplasma gondii	ck2 beta subunit	0.0044	0.0144	0.0503
Echinococcus multilocularis	CDC7 cell division cycle 7	0.007	0.0277	0.0314
Schistosoma mansoni	transient receptor potential channel	0.0064	0.0246	0.0701
Plasmodium vivax	protoporphyrinogen oxidase, putative	0.002	0.0021	0.004
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0046	0.0132
Plasmodium vivax	delta tubulin, putative	0.006	0.0227	0.0814
Trypanosoma cruzi	Casein kinase II subunit beta, putative	0.0044	0.0144	0.0503
Leishmania major	beta tubulin	0.0139	0.0632	0.2336
Entamoeba histolytica	casein kinase, putative	0.0082	0.0341	0.2672
Leishmania major	protein kinase ck2 regulatory subunit, putative	0.0044	0.0144	0.0503
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.01	0.0431	0.0595
Leishmania major	alpha tubulin	0.0258	0.1246	0.4643
Schistosoma mansoni	importin beta-1	0.0029	0.0064	0.0161
Echinococcus multilocularis	tubulin alpha chain	0.0258	0.1246	0.1459
Echinococcus granulosus	lysine specific histone demethylase 1A	0.002	0.0021	0.0032
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0044	0.0144	0.1052
Leishmania major	gamma-tubulin	0.0139	0.0632	0.2336
Brugia malayi	Transient-receptor-potential like protein	0.0036	0.0102	0.014
Leishmania major	beta tubulin	0.0139	0.0632	0.2336
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.006	0.0227	0.0814
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0129	0.0579	0.3831
Schistosoma mansoni	tar DNA-binding protein	0.0129	0.0579	0.1695
Giardia lamblia	Kinase, CMGC CK2	0.0082	0.0341	0.124

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 6.2 nM	Inhibition of N-terminus Myc-tagged human CDC7 expressed in Escherichia coli by chemiluminescence assay in presence of ATP	ChEMBL.	22560567
IC50 (binding)	= 22 nM	Inhibition of N-terminus His-tagged human PIM1 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by chemiluminescence assay	ChEMBL.	22560567
IC50 (binding)	= 50 nM	Inhibition of human tertrameric CK2alphabeta holoenzyme using casein as substrate after 1 to 2 hrs by chemiluminescence assay in presence of 2 uM ATP	ChEMBL.	22560567
IC50 (binding)	= 1434 nM	Inhibition of CDC7 in human MDA-MB-231T cells assessed as inhibition of MCM2 phosphorylation at Ser53 after 4 hrs	ChEMBL.	22560567

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2030396

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1656940