Detailed information for compound 1656953

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 438.478 | Formula: C26H22N4O3
  • H donors: 3 H acceptors: 4 LogP: 3.96 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1c2cc(ccc2c2c1cccc2)/C=c/1\[nH]c(=O)/c(=C/c2nc[nH]c2C(C)(C)C)/[nH]c1=O
  • InChi: 1S/C26H22N4O3/c1-26(2,3)23-19(27-13-28-23)12-21-25(33)29-20(24(32)30-21)11-14-8-9-16-15-6-4-5-7-17(15)22(31)18(16)10-14/h4-13H,1-3H3,(H,27,28)(H,29,33)(H,30,32)/b20-11-,21-12-
  • InChiKey: LSJZZVLXCPYLGK-ACXSEBCSSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus beta tubulin 0.0145 0.0589 0.2059
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0005 0.0001
Toxoplasma gondii beta tubulin 0.0145 0.0589 0.2165
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0005 0.0007
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.0046 0.0317
Treponema pallidum cell division protein FtsZ 0.0063 0.0235 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0005 0.0007
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0005 0.0039
Giardia lamblia Delta tubulin 0.0063 0.0235 0.0855
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0042 0.005
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0143 0.0581 0.0799
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0054 0.0183
Schistosoma mansoni intermediate filament proteins 0.0026 0.0076 0.0249
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0355
Giardia lamblia Beta tubulin 0.0145 0.0589 0.2168
Onchocerca volvulus 0.0011 0.0009 0.0004
Entamoeba histolytica tubulin family protein 0.0145 0.0589 0.5209
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0011 0.0009 0.0011
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0017 0.0024
Entamoeba histolytica tubulin family protein 0.0145 0.0589 0.5209
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0011 0.0009 0.0015
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0039
Echinococcus granulosus short transient receptor potential channel 6 0.0064 0.0239 0.0837
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.031 0.1301 1
Trypanosoma cruzi UDP-galactopyranose mutase 0.0021 0.0053 0.018
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0021 0.0053 0.018
Echinococcus granulosus intermediate filament protein 0.0026 0.0076 0.0265
Echinococcus granulosus importin subunit beta 1 0.0029 0.0087 0.0304
Loa Loa (eye worm) hypothetical protein 0.0026 0.0074 0.0573
Brugia malayi Tubulin beta chain 0.0082 0.0317 0.043
Trypanosoma cruzi zeta tubulin, putative 0.0063 0.0235 0.0852
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0009 0.0011
Schistosoma mansoni lamin 0.0026 0.0076 0.0249
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0041 0.026
Trichomonas vaginalis tubulin beta chain, putative 0.027 0.1127 1
Schistosoma mansoni hypothetical protein 0.0048 0.0171 0.0583
Trichomonas vaginalis tubulin epsilon chain, putative 0.0063 0.0235 0.2028
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0023 0.0025
Leishmania major beta tubulin 0.0145 0.0589 0.2165
Brugia malayi Tubulin beta chain 0.0063 0.0235 0.0317
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0042 0.0137
Brugia malayi Niemann-Pick C1 protein precursor 0.0107 0.0425 0.0579
Entamoeba histolytica fatty acid elongase, putative 0.004 0.0136 0.1174
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0042 0.0137
Brugia malayi Latrophilin receptor protein 2 0.0048 0.0171 0.0229
Brugia malayi hypothetical protein 0.0016 0.0033 0.0038
Trichomonas vaginalis tubulin alpha chain, putative 0.0082 0.0317 0.2765
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0009 0.0015
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0063 0.0218
Leishmania major hypothetical protein, conserved 0.0025 0.0071 0.0247
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0039
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0005 0.0007
Echinococcus multilocularis replication factor c subunit 1 0.0011 0.0009 0.0012
Loa Loa (eye worm) hypothetical protein 0.0013 0.0017 0.0133
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.022 0.0752
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0145 0.0589 0.2165
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0005 0.0001
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0071 0.0247
Loa Loa (eye worm) tubulin alpha chain 0.027 0.1127 0.8734
Entamoeba histolytica P-glycoprotein-2, putative 0.001 0.0008 0.0026
Schistosoma mansoni transient receptor potential channel 0.0097 0.0381 0.1318
Echinococcus multilocularis lamin dm0 0.0026 0.0076 0.0104
Loa Loa (eye worm) hypothetical protein 0.0021 0.0053 0.0412
Schistosoma mansoni tubulin subunit beta 0.0145 0.0589 0.2046
Brugia malayi glutaminase DH11.1 0.0266 0.1111 0.1525
Echinococcus granulosus multidrug resistance protein 1 0.001 0.0008 0.0026
Echinococcus granulosus Tubulin alpha 1 chain 0.027 0.1127 0.3938
Schistosoma mansoni tar DNA-binding protein 0.0131 0.0528 0.1833
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0063 0.0235 0.0852
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0021 0.0053 0.018
Leishmania major importin beta-1 subunit, putative 0.0023 0.0063 0.0218
Schistosoma mansoni ran 0.0021 0.0054 0.0173
Echinococcus granulosus Tubulin alpha 1 chain 0.027 0.1127 0.3938
Echinococcus granulosus tubulin gamma 1 chain 0.0145 0.0589 0.2059
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0071 0.0247
Loa Loa (eye worm) alpha-tubulin 0.027 0.1127 0.8734
Echinococcus granulosus snurportin 1 0.0307 0.129 0.4508
Plasmodium falciparum alpha tubulin 1 0.027 0.1127 0.4156
Trichomonas vaginalis tubulin, putative 0.0082 0.0317 0.2765
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0042 0.0253
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0146 0.0523
Giardia lamblia Alpha-tubulin 0.027 0.1127 0.4159
Brugia malayi multidrug resistance protein 3 0.001 0.0008 0.0004
Loa Loa (eye worm) hypothetical protein 0.0026 0.0074 0.0573
Schistosoma mansoni microtubule-associated protein tau 0.0671 0.2861 1
Plasmodium falciparum importin beta, putative 0.0029 0.0087 0.0305
Schistosoma mansoni coup transcription factor 0.001 0.0005 0.0001
Brugia malayi Tubulin gamma chain 0.0145 0.0589 0.0805
Loa Loa (eye worm) hypothetical protein 0.0011 0.0009 0.0068
Schistosoma mansoni tubulin subunit beta 0.0145 0.0589 0.2046
Loa Loa (eye worm) tubulin alpha 2 0.0125 0.05 0.3877
Mycobacterium ulcerans hypothetical protein 0.0159 0.0649 0.4969
Schistosoma mansoni topbp1 0.0011 0.0009 0.0015
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0054 0.0074
Loa Loa (eye worm) hypothetical protein 0.0061 0.0225 0.1747
Chlamydia trachomatis DNA ligase 0.0011 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0026 0.0076 0.0588
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.001 0.0008 0.0026
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0036 0.0118 0.0163
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0355
Echinococcus granulosus GPCR family 2 0.0048 0.0171 0.0598
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0042 0.0057
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0048 0.0171 0.0229
Trypanosoma brucei tubulin delta chain 0.0063 0.0235 0.0852
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0005 0.0007
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0042 0.0303
Echinococcus multilocularis tubulin alpha chain 0.027 0.1127 0.155
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0161 0.1371
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0039
Schistosoma mansoni hypothetical protein 0.0167 0.0684 0.2378
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0046 0.0161 0.1248
Entamoeba histolytica Ran family GTPase 0.0021 0.0054 0.044
Trypanosoma cruzi zeta tubulin, putative 0.0063 0.0235 0.0852
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0063 0.0235 0.0852
Chlamydia trachomatis oxoacyl-ACP synthase III 0.031 0.1301 1
Echinococcus multilocularis Tubulin beta 2C chain 0.0145 0.0589 0.081
Loa Loa (eye worm) hypothetical protein 0.0026 0.0074 0.0573
Echinococcus multilocularis Tubulin alpha 1 chain 0.027 0.1127 0.155
Toxoplasma gondii RNA-directed DNA polymerase 0.0635 0.2704 1
Echinococcus multilocularis tubulin epsilon chain 0.0145 0.0589 0.081
Brugia malayi hypothetical protein 0.023 0.0956 0.1311
Schistosoma mansoni tar DNA-binding protein 0.0131 0.0528 0.1833
Plasmodium vivax tubulin alpha chain, putative 0.027 0.1127 0.4156
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0042 0.0145
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0039
Schistosoma mansoni chromosome transmission fidelity factor 0.0011 0.0009 0.0015
Echinococcus granulosus tubulin alpha 1C chain 0.027 0.1127 0.3938
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0005 0.0007
Echinococcus multilocularis geminin 0.0167 0.0684 0.0941
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0059
Loa Loa (eye worm) tubulin alpha 2 0.0207 0.0855 0.6625
Leishmania major beta tubulin 0.0145 0.0589 0.2165
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0074 0.0618
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0005 0.0039
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0026 0.0074 0.0513
Echinococcus multilocularis short transient receptor potential channel 6 0.0064 0.0239 0.0329
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0074 0.0257
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0023 0.0061 0.0207
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0165 0.0221
Entamoeba histolytica hypothetical protein 0.0039 0.0132 0.1131
Leishmania major UDP-galactopyranose mutase 0.0021 0.0053 0.018
Echinococcus granulosus beta tubulin 0.0145 0.0589 0.2059
Onchocerca volvulus 0.0028 0.0084 0.0079
Echinococcus granulosus Tubulin beta 2C chain 0.0145 0.0589 0.2059
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0143 0.0581 0.4505
Schistosoma mansoni tubulin subunit epsilon 0.0145 0.0589 0.2046
Trypanosoma brucei beta tubulin 0.0145 0.0589 0.2165
Trypanosoma cruzi tubulin delta chain 0.0063 0.0235 0.0852
Plasmodium vivax tubulin gamma chain, putative 0.0145 0.0589 0.2165
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0021 0.0053 0.017
Loa Loa (eye worm) hypothetical protein 0.0036 0.0118 0.0916
Echinococcus granulosus Tubulin beta 2C chain 0.0145 0.0589 0.2059
Echinococcus multilocularis ATP binding cassette sub family G 0.001 0.0005 0.0006
Plasmodium falciparum multidrug resistance protein 1 0.001 0.0008 0.0011
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0048 0.0171 0.0598
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0074 0.0095
Leishmania major beta tubulin 0.0145 0.0589 0.2165
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0005 0.0007
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0143 0.0581 0.2018
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0143 0.0581 0.2018
Trichomonas vaginalis tubulin beta chain, putative 0.0082 0.0317 0.2765
Echinococcus multilocularis Tubulin beta 2C chain 0.0145 0.0589 0.081
Echinococcus granulosus tubulin alpha 3 chain 0.027 0.1127 0.3938
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.001 0.0008 0.0026
Brugia malayi TAR-binding protein 0.0131 0.0528 0.0721
Echinococcus multilocularis transient receptor potential gamma protein 0.0097 0.0381 0.0524
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0132 0.0444
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0074 0.0618
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.027 0.1127 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0009 0.0068
Plasmodium vivax multidrug resistance protein 1, putative 0.001 0.0008 0.0011
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0042 0.0285
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0005 0.0039
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0087 0.0305
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0009 0.0011
Giardia lamblia Beta tubulin 0.0145 0.0589 0.2168
Echinococcus granulosus tubulin delta chain 0.0063 0.0235 0.082
Schistosoma mansoni tubulin subunit delta 0.0063 0.0235 0.0805
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0042 0.0137
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0053 0.0352
Brugia malayi Pax transcription activation domain interacting protein 0.0011 0.0009 0.0005
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0063 0.0235 0.1747
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0087 0.0119
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0005 0.0001
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0005 0.0001
Echinococcus multilocularis 0.0021 0.0053 0.0073
Loa Loa (eye worm) hypothetical protein 0.0021 0.0053 0.0412
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0009 0.0015
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0009 0.0011
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0298 0.1249 0.9602
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0074 0.0535
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0143 0.0579 0.2128
Echinococcus multilocularis GPCR, family 2 0.0048 0.0171 0.0235
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0005 0.0001
Echinococcus granulosus cpg binding protein 0.003 0.0091 0.0317
Trypanosoma brucei beta tubulin 0.0145 0.0589 0.2165
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0005 0.0001
Loa Loa (eye worm) glutaminase 0.0266 0.1111 0.8611
Loa Loa (eye worm) hypothetical protein 0.0207 0.0855 0.6625
Schistosoma mansoni multidrug resistance protein 0.001 0.0008 0.001
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0071 0.0247
Schistosoma mansoni hypothetical protein 0.04 0.1688 0.5893
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0298 0.1249 0.9602
Entamoeba histolytica tubulin alpha-1 chain 0.027 0.1127 1
Mycobacterium ulcerans hypothetical protein 0.0026 0.0074 0.0535
Schistosoma mansoni amine oxidase 0.0021 0.0053 0.017
Brugia malayi hypothetical protein 0.0011 0.0009 0.0005
Trichomonas vaginalis tubulin beta chain, putative 0.027 0.1127 1
Plasmodium vivax tubulin beta chain, putative 0.0145 0.0589 0.2165
Leishmania major beta tubulin 0.0145 0.0589 0.2165
Entamoeba histolytica P-glycoprotein-2 0.001 0.0008 0.0026
Trypanosoma brucei beta tubulin 0.0145 0.0589 0.2165
Echinococcus multilocularis tar DNA binding protein 0.0131 0.0528 0.0727
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0042 0.0137
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0143 0.0581 0.2018
Echinococcus granulosus tubulin alpha chain 0.027 0.1127 0.3938
Schistosoma mansoni tubulin subunit beta 0.0145 0.0589 0.2046
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.001 0.0008 0.0011
Schistosoma mansoni alpha tubulin 0.027 0.1127 0.3928
Entamoeba histolytica tubulin alpha chain, putative 0.027 0.1127 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0005 0.0017
Schistosoma mansoni tubulin subunit alpha 0.027 0.1127 0.3928
Schistosoma mansoni alpha tubulin 0.027 0.1127 0.3928
Trichomonas vaginalis tubulin beta chain, putative 0.027 0.1127 1
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.001 0.0008 0.0026
Trichomonas vaginalis replication factor C large subunit, putative 0.0011 0.0009 0.0011
Entamoeba histolytica acyl-coA synthetase, putative 0.0026 0.0074 0.0618
Entamoeba histolytica fatty acid elongase, putative 0.004 0.0136 0.1174
Trichomonas vaginalis glutaminase, putative 0.0266 0.1111 0.9858
Toxoplasma gondii exonuclease III APE 0.0018 0.0042 0.0137
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0355
Loa Loa (eye worm) TAR-binding protein 0.0131 0.0528 0.4095
Loa Loa (eye worm) hypothetical protein 0.0056 0.0206 0.1595
Echinococcus granulosus lysine specific histone demethylase 1A 0.0021 0.0053 0.0186
Leishmania major beta tubulin 0.0145 0.0589 0.2165
Schistosoma mansoni tar DNA-binding protein 0.0131 0.0528 0.1833
Trichomonas vaginalis conserved hypothetical protein 0.0063 0.0235 0.2028
Echinococcus multilocularis transient receptor potential ion channel A 0.0094 0.0367 0.0505
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0021 0.0053 0.018
Echinococcus multilocularis tubulin alpha 3 chain 0.027 0.1127 0.155
Echinococcus multilocularis snurportin 1 0.0307 0.129 0.1774
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0071 0.0247
Schistosoma mansoni tubulin subunit alpha 0.0063 0.0235 0.0805
Leishmania major beta tubulin 0.0145 0.0589 0.2165
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0153 0.0622 0.085
Schistosoma mansoni ap endonuclease 0.0018 0.0042 0.0129
Mycobacterium tuberculosis 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) 0.031 0.1301 1
Echinococcus granulosus multidrug resistance protein 1 0.001 0.0008 0.0026
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0005 0.0007
Brugia malayi topoisomerase 0.0011 0.0009 0.0005
Schistosoma mansoni multidrug resistance protein 0.001 0.0008 0.001
Entamoeba histolytica P-glycoprotein-5 0.001 0.0008 0.0026
Loa Loa (eye worm) hypothetical protein 0.023 0.0956 0.741
Plasmodium vivax hypothetical protein, conserved 0.0021 0.0053 0.018
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.001 0.0008 0.0011
Entamoeba histolytica fatty acid elongase, putative 0.004 0.0136 0.1174
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0063 0.0498
Leishmania major beta tubulin 0.0145 0.0589 0.2165
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0153 0.0622 0.4818
Trypanosoma brucei zeta tubulin 0.0063 0.0235 0.0852
Echinococcus granulosus ATP binding cassette sub family G 0.001 0.0005 0.0016
Schistosoma mansoni hypothetical protein 0.0167 0.0684 0.2378
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0143 0.0579 0.2128
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0011 0.0009 0.0015
Leishmania major beta tubulin 0.0145 0.0589 0.2165
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1693 0.727 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0053 0.0412
Brugia malayi Telomerase reverse transcriptase 0.169 0.7258 1
Leishmania major delta tubulin, putative 0.0063 0.0235 0.0852
Echinococcus multilocularis expressed conserved protein 0.0101 0.0397 0.0546
Loa Loa (eye worm) hypothetical protein 0.0012 0.0015 0.0117
Plasmodium falciparum tubulin beta chain 0.0145 0.0589 0.2165
Echinococcus multilocularis ATP binding cassette sub family G 0.001 0.0005 0.0006
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.0046 0.0152
Echinococcus granulosus tubulin beta 1 chain 0.0145 0.0589 0.2059
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0087 0.0305
Onchocerca volvulus 0.001 0.0008 0.0003
Schistosoma mansoni thyroid hormone receptor 0.001 0.0005 0.0001
Brugia malayi Cell division protein ftsZ 0.0063 0.0235 0.0317
Leishmania major epsilon tubulin, putative 0.0145 0.0589 0.2165
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0042 0.0303
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0071 0.0247
Loa Loa (eye worm) multidrug resistance protein 3 0.001 0.0008 0.0059
Leishmania major alpha tubulin 0.027 0.1127 0.4156
Loa Loa (eye worm) hypothetical protein 0.0021 0.0053 0.0412
Schistosoma mansoni tar DNA-binding protein 0.0131 0.0528 0.1833
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0019 0.0046 0.0295
Trichomonas vaginalis tubulin gamma chain, putative 0.0145 0.0589 0.5196
Entamoeba histolytica hypothetical protein 0.0023 0.0063 0.0523
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0071 0.0247
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0005 0.0017
Schistosoma mansoni nuclear hormone receptor 0.001 0.0005 0.0001
Echinococcus granulosus Tubulin alpha 1 chain 0.027 0.1127 0.3938
Brugia malayi latrophilin 2 splice variant baaae 0.0104 0.0413 0.0563
Trypanosoma cruzi beta tubulin, putative 0.0145 0.0589 0.2165
Trichomonas vaginalis tubulin epsilon chain, putative 0.027 0.1127 1
Schistosoma mansoni tar DNA-binding protein 0.0131 0.0528 0.1833
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0048 0.0171 0.0235
Leishmania major beta tubulin 0.0145 0.0589 0.2165
Onchocerca volvulus 0.0026 0.0074 0.0069
Echinococcus granulosus transient receptor potential gamma protein 0.0097 0.0381 0.1332
Schistosoma mansoni ran 0.0021 0.0054 0.0173
Trypanosoma cruzi epsilon tubulin, putative 0.0145 0.0589 0.2165
Loa Loa (eye worm) tubulin beta-2A chain 0.0145 0.0589 0.4566
Echinococcus granulosus tubulin alpha chain 0.027 0.1127 0.3938
Schistosoma mansoni survival motor neuron protein 0.0047 0.0165 0.0562
Schistosoma mansoni tubulin subunit beta 0.0145 0.0589 0.2046
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.031 0.1301 1
Plasmodium vivax hypothetical protein, conserved 0.0021 0.0053 0.018
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.0074 0.0513
Loa Loa (eye worm) hypothetical protein 0.0107 0.0425 0.3296
Echinococcus granulosus tubulin subunit beta 0.0145 0.0589 0.2059
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0143 0.0581 0.2031
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0011 0.0009 0.0005
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0052 0.0186 0.0671
Trypanosoma brucei telomerase reverse transcriptase 0.0635 0.2704 1
Schistosoma mansoni hypothetical protein 0.0104 0.0413 0.143
Schistosoma mansoni alpha tubulin 0.027 0.1127 0.3928
Schistosoma mansoni hypothetical protein 0.0044 0.0154 0.0523
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.0011 0.0009 0.0032
Plasmodium vivax delta tubulin, putative 0.0063 0.0235 0.0852
Entamoeba histolytica hypothetical protein 0.0011 0.0009 0.0037
Schistosoma mansoni topbp1 0.0011 0.0009 0.0015
Echinococcus multilocularis Niemann Pick C1 protein 0.0153 0.0624 0.0858
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0302 0.1265 0.467
Echinococcus granulosus TRP transient receptor potential channel 0.0036 0.0118 0.0413
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0046 0.0295
Echinococcus granulosus nibrin 0.0011 0.0009 0.0031
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0041 0.026
Mycobacterium leprae cell division protein FtsZ 0.0063 0.0235 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0074 0.0535
Entamoeba histolytica fatty acid elongase, putative 0.004 0.0136 0.1174
Echinococcus multilocularis tubulin gamma 1 chain 0.0145 0.0589 0.081
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0005 0.0001
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.001 0.0008 0.0059
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0005 0.0017
Schistosoma mansoni hypothetical protein 0.0047 0.0165 0.0562
Onchocerca volvulus 0.0026 0.0076 0.0071
Toxoplasma gondii alpha tubulin TUBA1 0.027 0.1127 0.4156
Echinococcus multilocularis Tubulin beta 2C chain 0.0145 0.0589 0.081
Schistosoma mansoni hypothetical protein 0.0048 0.0171 0.0583
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0143 0.0579 0.2128
Brugia malayi SWIRM domain containing protein 0.0021 0.0053 0.0066
Brugia malayi tubulin alpha chain - mouse 0.027 0.1127 0.1546
Loa Loa (eye worm) hypothetical protein 0.0011 0.0009 0.0068
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0011 0.0009 0.0011
Echinococcus multilocularis tubulin delta chain 0.0063 0.0235 0.0323
Plasmodium falciparum tubulin epsilon chain, putative 0.0145 0.0589 0.2165
Echinococcus granulosus Tubulin beta 2C chain 0.0145 0.0589 0.2059
Brugia malayi beta-tubulin, identical 0.0145 0.0589 0.0805
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0005 0.0017
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0063 0.0235 0.2028
Trypanosoma brucei epsilon tubulin 0.0145 0.0589 0.2165
Loa Loa (eye worm) tubulin beta-1 chain 0.0145 0.0589 0.4566
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0005 0.0039
Echinococcus granulosus multidrug resistance protein 1 0.001 0.0008 0.0026
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0017 0.006
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0635 0.2704 1
Mycobacterium tuberculosis Possible oxidoreductase 0.0021 0.0053 0.0352
Entamoeba histolytica hypothetical protein 0.0039 0.0132 0.1131
Brugia malayi DKFZp564C0469 protein 0.0011 0.0009 0.0005
Toxoplasma gondii beta-tubulin, putative 0.0145 0.0589 0.2165
Mycobacterium ulcerans cell division protein FtsZ 0.0063 0.0235 0.1774
Brugia malayi RNA, U transporter 1 0.0082 0.0316 0.0429
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0207 0.0855 0.7569
Trypanosoma brucei epsilon tubulin 0.0145 0.0589 0.2165
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0635 0.2704 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0009 0.0068
Leishmania major alpha tubulin 0.027 0.1127 0.4156
Loa Loa (eye worm) hypothetical protein 0.0097 0.0381 0.2954
Echinococcus granulosus replication factor c subunit 1 0.0011 0.0009 0.0031
Schistosoma mansoni tubulin subunit beta 0.0063 0.0235 0.0805
Mycobacterium tuberculosis Conserved hypothetical protein 0.0159 0.0649 0.4958
Echinococcus multilocularis tubulin alpha chain 0.027 0.1127 0.155
Echinococcus granulosus Protein patched homolog 1 0.0046 0.0161 0.0563
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0005 0.0007
Schistosoma mansoni transient receptor potential channel 4 0.0097 0.0381 0.1318
Echinococcus multilocularis Tubulin alpha 1 chain 0.027 0.1127 0.155
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0076 0.0588
Entamoeba histolytica hypothetical protein 0.0039 0.0132 0.1131
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0009 0.0011
Echinococcus granulosus tubulin alpha chain 0.027 0.1127 0.3938
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0084 0.0649
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0051
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0302 0.1265 0.467
Schistosoma mansoni thyroid hormone receptor 0.001 0.0005 0.0001
Echinococcus multilocularis tubulin alpha 3 chain 0.027 0.1127 0.155
Trypanosoma cruzi tubulin gamma chain 0.0145 0.0589 0.2165
Trichomonas vaginalis tubulin gamma chain, putative 0.0063 0.0235 0.2028
Onchocerca volvulus 0.0047 0.0165 0.016
Toxoplasma gondii histone lysine-specific demethylase 0.0021 0.0053 0.018
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0048 0.0171 0.0598
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0011 0.0039
Loa Loa (eye worm) hypothetical protein 0.0025 0.0071 0.0552
Schistosoma mansoni lamin 0.0026 0.0076 0.0249
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0011 0.0015
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0005 0.0001
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.001 0.0008 0.001
Loa Loa (eye worm) hypothetical protein 0.0011 0.0009 0.0068
Leishmania major alpha tubulin 0.027 0.1127 0.4156
Trypanosoma brucei tubulin gamma chain 0.0145 0.0589 0.2165
Trichomonas vaginalis tubulin beta chain, putative 0.0145 0.0589 0.5196
Plasmodium vivax tubulin alpha chain, putative 0.027 0.1127 0.4156
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0146 0.0523
Schistosoma mansoni smdr2 0.001 0.0008 0.001
Brugia malayi Tubulin beta-1 chain 0.0145 0.0589 0.0805
Echinococcus multilocularis survival motor neuron protein 1 0.023 0.0956 0.1315
Plasmodium vivax tubulin epsilon chain, putative 0.0145 0.0589 0.2165
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0302 0.1265 0.467
Schistosoma mansoni hypothetical protein 0.0044 0.0154 0.0523
Schistosoma mansoni hypothetical protein 0.0039 0.0132 0.0444
Echinococcus multilocularis Tubulin beta 2C chain 0.0145 0.0589 0.081
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.001 0.0008 0.0026
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0074 0.0257
Leishmania major gamma-tubulin 0.0145 0.0589 0.2165
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0005 0.0001
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0307 0.129 1
Schistosoma mansoni glutaminase 0.0266 0.1111 0.3872
Trichomonas vaginalis tubulin alpha chain, putative 0.0145 0.0589 0.5196
Schistosoma mansoni cpg binding protein 0.0028 0.0084 0.0277
Trichomonas vaginalis ran, putative 0.0021 0.0054 0.0415
Entamoeba histolytica tubulin gamma chain 0.0145 0.0589 0.5209
Echinococcus granulosus tar DNA binding protein 0.0131 0.0528 0.1846
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0042 0.0137
Leishmania major alpha tubulin 0.027 0.1127 0.4156
Schistosoma mansoni transient receptor potential channel 0.0064 0.0239 0.0822
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0074 0.2885
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0011 0.0009 0.0011
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0076 0.0588
Leishmania major alpha tubulin 0.027 0.1127 0.4156
Echinococcus multilocularis tubulin beta 1 chain 0.0145 0.0589 0.081
Entamoeba histolytica P-glycoprotein 5, putative 0.001 0.0008 0.0026
Echinococcus multilocularis tubulin alpha chain 0.027 0.1127 0.155
Trypanosoma cruzi tubulin delta chain 0.0063 0.0235 0.0852
Mycobacterium ulcerans dehydrogenase 0.0021 0.0053 0.0374
Echinococcus granulosus ATP binding cassette sub family G 0.001 0.0005 0.0016
Echinococcus granulosus short transient receptor potential channel 6 0.0064 0.0239 0.0837
Loa Loa (eye worm) BEN-1 protein 0.0145 0.0589 0.4566
Brugia malayi tubulin alpha-2 chain 0.027 0.1127 0.1546
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0074 0.2885
Echinococcus granulosus alpha tubulin 0.027 0.1127 0.3938
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0005 0.0039
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0131 0.0528 0.4095
Echinococcus multilocularis Tubulin alpha 1 chain 0.027 0.1127 0.155
Loa Loa (eye worm) tubulin beta chain 0.0145 0.0589 0.4566
Plasmodium vivax beta-ketoacyl-acyl carrier protein synthase III precursor, putative 0.031 0.1301 0.4802
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0026 0.0074 0.0535
Trichomonas vaginalis conserved hypothetical protein 0.0063 0.0235 0.2028
Schistosoma mansoni importin beta-1 0.0029 0.0087 0.0288
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0143 0.0581 0.2031
Loa Loa (eye worm) hypothetical protein 0.0188 0.0772 0.5986
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.001 0.0008 0.0011
Echinococcus multilocularis short transient receptor potential channel 6 0.0064 0.0239 0.0329
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0039
Echinococcus multilocularis microtubule associated protein 2 0.0671 0.2861 0.3936
Plasmodium falciparum protoporphyrinogen oxidase 0.0021 0.0053 0.018
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0041 0.026
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.031 0.1301 1
Leishmania major beta tubulin 0.0145 0.0589 0.2165
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0005 0.0017
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0026 0.0074 0.0535
Echinococcus multilocularis dnaJ subfamily B 0.04 0.1688 0.2322
Mycobacterium ulcerans glutaminase 0.0266 0.1111 0.8534
Leishmania major beta tubulin 0.0145 0.0589 0.2165
Echinococcus granulosus peroxisome assembly protein 26 0.027 0.1127 0.3938
Brugia malayi ABC transporter family protein 0.001 0.0008 0.0004
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0355
Brugia malayi Transient-receptor-potential like protein 0.0036 0.0118 0.0156
Trypanosoma brucei beta tubulin 0.0145 0.0589 0.2165
Loa Loa (eye worm) hypothetical protein 0.0012 0.0015 0.0117
Echinococcus multilocularis sterol regulatory element binding protein 0.0046 0.0161 0.0222
Entamoeba histolytica P-glycoprotein-2 0.001 0.0008 0.0026
Echinococcus granulosus FTZ F1 alpha 0.001 0.0005 0.0017
Trichomonas vaginalis tubulin, putative 0.0145 0.0589 0.5196
Loa Loa (eye worm) latrophilin receptor protein 2 0.0048 0.0171 0.1326
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0132 0.046
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0146 0.0523
Trichomonas vaginalis tubulin alpha chain, putative 0.0082 0.0317 0.2765
Giardia lamblia Beta tubulin 0.0145 0.0589 0.2168
Echinococcus multilocularis multidrug resistance protein 1 0.001 0.0008 0.001
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0143 0.0581 0.0799
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0192 0.0694
Echinococcus multilocularis musashi 0.0026 0.0076 0.0104
Entamoeba histolytica hypothetical protein 0.0039 0.0132 0.1131
Schistosoma mansoni hypothetical protein 0.0048 0.0171 0.0583
Schistosoma mansoni hypothetical protein 0.0307 0.129 0.45
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.001 0.0008 0.001
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0042 0.145
Leishmania major alpha tubulin 0.027 0.1127 0.4156
Trypanosoma brucei zeta tubulin, putative 0.0063 0.0235 0.0852
Plasmodium falciparum telomerase reverse transcriptase 0.0635 0.2704 1
Brugia malayi Tubulin alpha chain 0.027 0.1127 0.1546
Trichomonas vaginalis tubulin beta chain, putative 0.027 0.1127 1
Brugia malayi Importin beta-1 subunit 0.0029 0.0087 0.0113
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0063 0.0498
Brugia malayi CXXC zinc finger family protein 0.0028 0.0084 0.0109
Echinococcus granulosus sterol regulatory element binding protein 0.0046 0.0161 0.0563
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.0046 0.0152
Echinococcus granulosus tubulin epsilon chain 0.0145 0.0589 0.2059
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0005 0.0017
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0071 0.0247
Trichomonas vaginalis tubulin epsilon chain, putative 0.0145 0.0589 0.5196
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0107 0.0425 0.3748
Leishmania major alpha tubulin 0.027 0.1127 0.4156
Loa Loa (eye worm) hypothetical protein 0.0021 0.0053 0.0412
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0054 0.0189
Loa Loa (eye worm) tubulin beta-4 chain 0.0145 0.0589 0.4566
Schistosoma mansoni DNA ligase IV 0.0011 0.0009 0.0015
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0082 0.0317 0.2765
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0054 0.0183
Loa Loa (eye worm) RNA binding protein 0.0131 0.0528 0.4095
Echinococcus granulosus lamin 0.0026 0.0076 0.0265
Schistosoma mansoni tubulin subunit beta 0.0145 0.0589 0.2046
Loa Loa (eye worm) hypothetical protein 0.0033 0.0104 0.0808
Schistosoma mansoni cpg binding protein 0.003 0.0091 0.0301
Brugia malayi Tubulin alpha-2 chain 0.027 0.1127 0.1546
Entamoeba histolytica P-glyco protein 6, putative 0.001 0.0008 0.0026
Schistosoma mansoni tubulin subunit gamma 0.0145 0.0589 0.2046
Schistosoma mansoni patched 1 0.0046 0.0161 0.0548
Trichomonas vaginalis tubulin, putative 0.0082 0.0317 0.2765
Trichomonas vaginalis tubulin epsilon chain, putative 0.027 0.1127 1
Plasmodium falciparum tubulin delta chain, putative 0.0063 0.0235 0.0852
Echinococcus granulosus tubulin subunit TubB 0.027 0.1127 0.3938
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0188 0.0772 0.6832
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0005 0.0017
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0132 0.0181
Echinococcus multilocularis tubulin alpha 1C chain 0.027 0.1127 0.155
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0039
Echinococcus granulosus microtubule associated protein 2 0.0671 0.2861 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0048 0.0171 0.0235
Brugia malayi amine oxidase, flavin-containing family protein 0.0021 0.0053 0.0066
Brugia malayi Tubulin alpha chain 0.0063 0.0235 0.0317
Giardia lamblia Replication factor C, subunit 1 0.0011 0.0009 0.0019
Echinococcus multilocularis protein patched 0.0046 0.0161 0.0222
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0054 0.0183
Giardia lamblia Epsilon tubulin 0.0063 0.0235 0.0855
Echinococcus multilocularis tubulin subunit beta 0.0145 0.0589 0.081
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0021 0.0053 0.1964
Schistosoma mansoni tubulin subunit beta 0.0145 0.0589 0.2046
Entamoeba histolytica fatty acid elongase, putative 0.004 0.0136 0.1174
Toxoplasma gondii alpha-tubulin I, putative 0.027 0.1127 0.4156
Leishmania major alpha tubulin 0.027 0.1127 0.4156
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0005 0.0007
Echinococcus granulosus Tubulin beta 2C chain 0.0145 0.0589 0.2059
Echinococcus multilocularis protoporphyrinogen oxidase 0.0021 0.0053 0.0073
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0021 0.0053 0.0374
Echinococcus granulosus Niemann Pick C1 protein 0.0107 0.0425 0.1486
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0054 0.0068
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0042 0.0137
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.001 0.0008 0.001
Leishmania major alpha tubulin 0.027 0.1127 0.4156
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0074 0.0257
Echinococcus multilocularis hypothetical protein 0.027 0.1127 0.155
Toxoplasma gondii hypothetical protein 0.0049 0.0173 0.0622
Trichomonas vaginalis tubulin, putative 0.0063 0.0235 0.2028
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0063 0.0498
Trichomonas vaginalis tubulin gamma chain, putative 0.0145 0.0589 0.5196
Schistosoma mansoni multidrug resistance protein 0.001 0.0008 0.001
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0074 0.0095
Brugia malayi hypothetical protein 0.0011 0.0009 0.0005
Loa Loa (eye worm) tubulin alpha-2 chain 0.027 0.1127 0.8734
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0054 0.0183
Plasmodium vivax replication factor C subunit 1, putative 0.0011 0.0009 0.0015
Echinococcus granulosus tubulin alpha 3 chain 0.027 0.1127 0.3938
Trichomonas vaginalis tubulin epsilon chain, putative 0.0145 0.0589 0.5196
Plasmodium falciparum alpha tubulin 2 0.027 0.1127 0.4156
Trypanosoma cruzi epsilon tubulin, putative 0.0145 0.0589 0.2165
Brugia malayi RNA binding protein 0.0131 0.0528 0.0721
Loa Loa (eye worm) hypothetical protein 0.027 0.1127 0.8734
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0059
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.001 0.0008 0.001
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0005 0.0017
Trypanosoma brucei alpha tubulin 0.027 0.1127 0.4156
Plasmodium falciparum tubulin gamma chain 0.0145 0.0589 0.2165
Echinococcus multilocularis protein dispatched 1 0.0052 0.0189 0.026
Toxoplasma gondii beta-1 tubulin, putative 0.0145 0.0589 0.2165
Echinococcus multilocularis tubulin subunit TubB 0.027 0.1127 0.155
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0087 0.0305
Loa Loa (eye worm) glutaminase 2 0.0266 0.1111 0.8611
Echinococcus granulosus expressed conserved protein 0.0101 0.0397 0.1388
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0041 0.026
Trypanosoma brucei beta tubulin 0.0145 0.0589 0.2165
Loa Loa (eye worm) hypothetical protein 0.0048 0.0171 0.1326
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0076 0.0098
Echinococcus granulosus tubulin alpha 0.0145 0.0589 0.2059
Leishmania major mitochondrial DNA polymerase beta 0.0302 0.1265 0.467
Onchocerca volvulus 0.0082 0.0317 0.0312
Echinococcus granulosus lysine specific histone demethylase 1A 0.0021 0.0053 0.0186
Leishmania major p-glycoprotein 0.001 0.0008 0.0011
Leishmania major beta tubulin 0.0145 0.0589 0.2165
Schistosoma mansoni transient receptor potential channel 0.0064 0.0239 0.0822
Echinococcus multilocularis beta tubulin 0.0145 0.0589 0.081
Schistosoma mansoni tubulin subunit alpha 0.027 0.1127 0.3928
Leishmania major alpha tubulin 0.027 0.1127 0.4156
Loa Loa (eye worm) hypothetical protein 0.0029 0.0087 0.0673
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0054 0.0187
Onchocerca volvulus 0.0021 0.0053 0.0048
Schistosoma mansoni hypothetical protein 0.0044 0.0154 0.0523
Loa Loa (eye worm) hypothetical protein 0.0153 0.0622 0.4818
Trichomonas vaginalis tubulin alpha chain, putative 0.0145 0.0589 0.5196
Echinococcus multilocularis nibrin 0.0011 0.0009 0.0012
Schistosoma mansoni cpg binding protein 0.003 0.0091 0.0301
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0074 0.0095
Loa Loa (eye worm) tubulin alpha 2 0.0207 0.0855 0.6625
Echinococcus granulosus Niemann Pick C1 protein 0.0153 0.0624 0.218
Echinococcus multilocularis Niemann Pick C1 protein 0.0107 0.0425 0.0585
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0042 0.0262
Echinococcus multilocularis cpg binding protein 0.003 0.0091 0.0125
Brugia malayi RNA recognition motif domain containing protein 0.0131 0.0528 0.0721
Brugia malayi CHE-14 protein 0.0046 0.0161 0.0215
Brugia malayi hypothetical protein 0.0025 0.0071 0.0091
Loa Loa (eye worm) BEN-1 protein 0.0145 0.0589 0.4566
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0074 0.0535
Schistosoma mansoni amine oxidase 0.0021 0.0053 0.017
Trichomonas vaginalis tubulin beta chain, putative 0.027 0.1127 1
Trypanosoma cruzi FHA domain containing protein, putative 0.0011 0.0009 0.0015
Echinococcus multilocularis tubulin alpha chain 0.027 0.1127 0.155
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0023 0.018
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0011 0.0009 0.0011
Schistosoma mansoni hypothetical protein 0.0044 0.0154 0.0523
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0011 0.0009 0.0037
Brugia malayi intermediate filament protein 0.0026 0.0076 0.0098
Entamoeba histolytica P-glycoprotein-1 0.001 0.0008 0.0026
Loa Loa (eye worm) tubulin gamma chain 0.0145 0.0589 0.4566
Trypanosoma brucei alpha tubulin 0.027 0.1127 0.4156
Giardia lamblia Alpha-tubulin 0.027 0.1127 0.4159
Brugia malayi alpha-tubulin 0.027 0.1127 0.1546
Echinococcus granulosus Tubulin beta 2C chain 0.0145 0.0589 0.2059
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0143 0.0581 0.0794
Leishmania major alpha tubulin 0.027 0.1127 0.4156
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0026 0.0074 0.0535
Echinococcus multilocularis Tubulin beta 2C chain 0.0145 0.0589 0.081
Leishmania major GTP-binding protein, putative 0.0021 0.0054 0.0183
Trypanosoma brucei alpha tubulin 0.027 0.1127 0.4156
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0277 0.1159 0.89
Loa Loa (eye worm) hypothetical protein 0.0104 0.0413 0.3202
Giardia lamblia Telomerase catalytic subunit 0.0635 0.2704 1
Onchocerca volvulus 0.0026 0.0076 0.0071
Mycobacterium ulcerans monoamine oxidase 0.0021 0.0053 0.0374
Brugia malayi hypothetical protein 0.0039 0.0132 0.0175
Echinococcus granulosus dnaJ subfamily B 0.04 0.1688 0.59
Mycobacterium ulcerans oxidoreductase 0.0021 0.0053 0.0374
Loa Loa (eye worm) hypothetical protein 0.0046 0.0161 0.1248
Echinococcus granulosus survival motor neuron protein 1 0.023 0.0956 0.3341
Echinococcus multilocularis peroxisome assembly protein 26 0.027 0.1127 0.155
Leishmania major beta tubulin 0.0145 0.0589 0.2165
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0021 0.0053 0.017
Giardia lamblia Gamma tubulin 0.0145 0.0589 0.2168
Loa Loa (eye worm) hypothetical protein 0.0026 0.0074 0.0571
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0039
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0146 0.0523
Echinococcus multilocularis ATP binding cassette sub family B 0.001 0.0007 0.0009
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0207 0.0855 0.6625
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0021 0.0053 0.0073
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0005 0.0039
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0011 0.0009 0.0015
Echinococcus multilocularis tubulin alpha 1C chain 0.027 0.1127 0.155
Loa Loa (eye worm) alpha-tubulin 0.027 0.1127 0.8734
Leishmania major beta tubulin 0.0145 0.0589 0.2165
Leishmania major zeta tubulin, putative 0.0063 0.0235 0.0852
Schistosoma mansoni hypothetical protein 0.0011 0.0011 0.0023
Echinococcus granulosus transient receptor potential ion channel A 0.0094 0.0367 0.1283
Echinococcus granulosus ATP binding cassette sub family G 0.001 0.0005 0.0016
Leishmania major beta tubulin 0.0145 0.0589 0.2165
Echinococcus multilocularis ATP binding cassette sub family G 0.001 0.0005 0.0006
Leishmania major telomerase reverse transcriptase, putative 0.0635 0.2704 1
Leishmania major alpha tubulin 0.027 0.1127 0.4156
Loa Loa (eye worm) tubulin alpha chain 0.027 0.1127 0.8734
Trypanosoma brucei epsilon tubulin 0.0145 0.0589 0.2165
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0054 0.0183
Echinococcus granulosus tubulin alpha 1C chain 0.027 0.1127 0.3938
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0042 0.0322
Loa Loa (eye worm) tubulin beta chain 0.0063 0.0235 0.1818
Echinococcus granulosus tubulin alpha chain 0.027 0.1127 0.3938
Echinococcus granulosus lamin dm0 0.0026 0.0076 0.0265
Trichomonas vaginalis tubulin beta chain, putative 0.027 0.1127 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0026 0.0074 0.0535
Echinococcus multilocularis lamin 0.0026 0.0076 0.0104
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0039
Schistosoma mansoni ap endonuclease 0.0018 0.0042 0.0129
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0042 0.014
Leishmania major beta tubulin 0.0145 0.0589 0.2165
Echinococcus granulosus tubulin alpha chain 0.027 0.1127 0.3938
Mycobacterium tuberculosis Cell division protein FtsZ 0.0063 0.0235 0.1755
Schistosoma mansoni tubulin subunit alpha 0.027 0.1127 0.3928
Trypanosoma cruzi alpha tubulin, putative 0.027 0.1127 0.4156
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0005 0.0039
Trichomonas vaginalis tubulin gamma chain, putative 0.0145 0.0589 0.5196
Loa Loa (eye worm) hypothetical protein 0.0011 0.0009 0.0068
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0355
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0054 0.0183
Echinococcus granulosus geminin 0.0167 0.0684 0.239
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.001 0.0008 0.001
Trypanosoma brucei alpha tubulin, putative 0.0082 0.0317 0.1157
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0005 0.0039
Mycobacterium ulcerans beta-ketoacyl synthase-like protein 0.031 0.1301 1
Leishmania major beta tubulin 0.0145 0.0589 0.2165
Echinococcus multilocularis beta tubulin 0.0145 0.0589 0.081
Plasmodium vivax importin-beta 2, putative 0.0029 0.0087 0.0305
Loa Loa (eye worm) beta-tubulin 0.0145 0.0589 0.4566
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0042 0.0329
Echinococcus multilocularis tubulin alpha chain 0.027 0.1127 0.155
Trypanosoma cruzi UDP-galactopyranose mutase 0.0021 0.0053 0.018
Plasmodium vivax telomerase reverse transcriptase, putative 0.0635 0.2704 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0053 0.0412
Chlamydia trachomatis protoporphyrinogen oxidase 0.0021 0.0053 0.0352
Schistosoma mansoni hypothetical protein 0.0048 0.0171 0.0583
Leishmania major beta tubulin 0.0145 0.0589 0.2165
Trichomonas vaginalis tubulin alpha chain, putative 0.0082 0.0317 0.2765
Loa Loa (eye worm) tubulin alpha-3 chain 0.0188 0.0772 0.5986
Trypanosoma brucei alpha tubulin 0.027 0.1127 0.4156
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0109 0.0432 0.1497
Brugia malayi Tubulin alpha-2 chain 0.027 0.1127 0.1546
Brugia malayi Calcitonin receptor-like protein seb-1 0.0153 0.0622 0.085
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0009 0.0011
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0054 0.0419
Echinococcus granulosus tubulin beta 4A class IVa 0.0145 0.0589 0.2059
Toxoplasma gondii ATPase, AAA family protein 0.0011 0.0009 0.0015
Echinococcus multilocularis multidrug resistance protein 1 0.001 0.0008 0.001
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0021 0.0053 0.018
Echinococcus multilocularis tubulin alpha 0.0145 0.0589 0.081
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.001 0.0007 0.0023
Plasmodium falciparum replication factor C subunit 1, putative 0.0011 0.0009 0.0015
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0145 0.0589 0.081
Plasmodium falciparum beta-ketoacyl-ACP synthase III 0.031 0.1301 0.4802
Brugia malayi hypothetical protein 0.0021 0.0053 0.0066

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 2800 nM Cytotoxicity against human HT-29 cells after 48 hrs by resazurin assay ChEMBL. 22727370

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 22727370

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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