Detailed information for compound 1656962

Basic information

Technical information
  • TDR Targets ID: 1656962
  • Name: propan-2-yl (2R,4S)-4-[[2-(2-aminoethyl)tetra zol-5-yl]-[[3,5-bis(trifluoromethyl)phenyl]me thyl]amino]-2-ethyl-6-(trifluoromethyl)-3,4-d ihydro-2H-quinoline-1-carboxylate
  • MW: 667.569 | Formula: C28H30F9N7O2
  • H donors: 1 H acceptors: 4 LogP: 6.9 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 2
  • SMILES: NCCn1nnc(n1)N([C@H]1C[C@@H](CC)N(c2c1cc(cc2)C(F)(F)F)C(=O)OC(C)C)Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F
  • InChi: 1S/C28H30F9N7O2/c1-4-20-13-23(21-12-17(26(29,30)31)5-6-22(21)44(20)25(45)46-15(2)3)42(24-39-41-43(40-24)8-7-38)14-16-9-18(27(32,33)34)11-19(10-16)28(35,36)37/h5-6,9-12,15,20,23H,4,7-8,13-14,38H2,1-3H3/t20-,23+/m1/s1
  • InChiKey: VKCTUQWVWVLYST-OFNKIYASSA-N  


Substructure search Similarity search

Network

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Synonyms

  • isopropyl (2R,4S)-4-[[2-(2-aminoethyl)tetrazol-5-yl]-[[3,5-bis(trifluoromethyl)phenyl]methyl]amino]-2-ethyl-6-(trifluoromethyl)-3,4-dihydro-2H-quinoline-1-carboxylate
  • (2R,4S)-4-[[2-(2-aminoethyl)-5-tetrazolyl]-[[3,5-bis(trifluoromethyl)phenyl]methyl]amino]-2-ethyl-6-(trifluoromethyl)-3,4-dihydro-2H-quinoline-1-carboxylic acid isopropyl ester
  • (2R,4S)-4-[[2-(2-aminoethyl)tetrazol-5-yl]-[3,5-bis(trifluoromethyl)benzyl]amino]-2-ethyl-6-(trifluoromethyl)-3,4-dihydro-2H-quinoline-1-carboxylic acid isopropyl ester
  • propan-2-yl (2R,4S)-4-[[2-(2-aminoethyl)-1,2,3,4-tetrazol-5-yl]-[[3,5-bis(trifluoromethyl)phenyl]methyl]amino]-2-ethyl-6-(trifluoromethyl)-3,4-dihydro-2H-quinoline-1-carboxylate

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cholesteryl ester transfer protein, plasma Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis tubulin alpha chain, putative 0.0081 0.0202 0.2639
Echinococcus multilocularis geminin 0.0171 0.0481 0.0621
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0083 0.0211 0.0272
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0087 0.0322
Onchocerca volvulus 0.0023 0.0027 0.0027
Mycobacterium ulcerans hypothetical protein 0.005 0.0108 0.0301
Plasmodium vivax beta-ketoacyl-acyl carrier protein synthase III precursor, putative 0.0308 0.0899 0.3332
Leishmania major alpha tubulin 0.0264 0.0767 0.2842
Schistosoma mansoni tubulin subunit beta 0.0142 0.0392 0.0637
Schistosoma mansoni hypothetical protein 0.0065 0.0156 0.0254
Plasmodium falciparum acyl-CoA synthetase 0.0037 0.0069 0.0257
Brugia malayi latrophilin 2 splice variant baaae 0.0141 0.039 0.0537
Entamoeba histolytica fatty acid elongase, putative 0.004 0.0078 0.1014
Plasmodium vivax tubulin epsilon chain, putative 0.0142 0.0392 0.1453
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0079 0.0102
Leishmania major hypothetical protein, conserved 0.0026 0.0036 0.0132
Brugia malayi ShTK domain containing protein 0.0272 0.0791 0.109
Echinococcus multilocularis tubulin alpha 1C chain 0.0264 0.0767 0.0991
Brugia malayi AMP-binding enzyme family protein 0.005 0.0108 0.0149
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0142 0.0392 0.0506
Trypanosoma brucei alpha tubulin 0.0264 0.0767 0.2842
Trichomonas vaginalis tubulin beta chain, putative 0.0264 0.0767 1
Trichomonas vaginalis tubulin, putative 0.0081 0.0202 0.2639
Trypanosoma brucei beta tubulin 0.0142 0.0392 0.1453
Trypanosoma brucei beta tubulin 0.0142 0.0392 0.1453
Trypanosoma brucei alpha tubulin, putative 0.0081 0.0202 0.075
Schistosoma mansoni tubulin subunit beta 0.0062 0.0145 0.0235
Onchocerca volvulus Huntingtin homolog 0.012 0.0323 0.0323
Echinococcus multilocularis musashi 0.0026 0.0036 0.0047
Echinococcus multilocularis tubulin alpha chain 0.0264 0.0767 0.0991
Echinococcus granulosus tubulin subunit beta 0.0142 0.0392 0.0637
Schistosoma mansoni hypothetical protein 0.032 0.0937 0.1521
Echinococcus multilocularis expressed conserved protein 0.0103 0.0273 0.0352
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.005 0.0108 0.0324
Leishmania major beta tubulin 0.0142 0.0392 0.1453
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0037 0.0069 0.0208
Loa Loa (eye worm) hypothetical protein 0.0023 0.0027 0.0206
Loa Loa (eye worm) ShTK domain-containing protein 0.0272 0.0791 0.6094
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0308 0.0899 0.2509
Loa Loa (eye worm) hypothetical protein 0.0034 0.006 0.0462
Echinococcus granulosus tubulin gamma 1 chain 0.0142 0.0392 0.0637
Schistosoma mansoni tubulin subunit alpha 0.0264 0.0767 0.1246
Trypanosoma cruzi alpha tubulin, putative 0.0264 0.0767 0.2842
Plasmodium falciparum tubulin beta chain 0.0142 0.0392 0.1453
Echinococcus multilocularis beta tubulin 0.0142 0.0392 0.0506
Entamoeba histolytica tubulin gamma chain 0.0142 0.0392 0.5112
Schistosoma mansoni alpha tubulin 0.0264 0.0767 0.1246
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0023 0.0176
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0145 0.1889
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.005 0.0108 0.5115
Echinococcus granulosus transient receptor potential ion channel A 0.0097 0.0254 0.0413
Giardia lamblia Beta tubulin 0.0142 0.0392 0.138
Trypanosoma cruzi tubulin delta chain 0.0062 0.0145 0.0537
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0272 0.0791 0.109
Brugia malayi Transient-receptor-potential like protein 0.0037 0.007 0.0097
Toxoplasma gondii Erv1 / Alr family protein 0.0034 0.0058 0.0216
Trypanosoma brucei alpha tubulin 0.0264 0.0767 0.2842
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0065 0.0156 0.0254
Brugia malayi LBP / BPI / CETP family, C-terminal domain containing protein 0.0023 0.0027 0.0037
Echinococcus multilocularis tubulin alpha chain 0.0264 0.0767 0.0991
Leishmania major alpha tubulin 0.0264 0.0767 0.2842
Entamoeba histolytica hypothetical protein 0.0024 0.003 0.0388
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0023 0.0085
Echinococcus granulosus GPCR family 2 0.0065 0.0156 0.0254
Loa Loa (eye worm) hypothetical protein 0.0017 0.0008 0.0065
Giardia lamblia Gamma tubulin 0.0142 0.0392 0.138
Brugia malayi AMP-binding enzyme family protein 0.005 0.0108 0.0149
Loa Loa (eye worm) tubulin beta-1 chain 0.0142 0.0392 0.3022
Plasmodium falciparum tubulin delta chain, putative 0.0062 0.0145 0.0537
Loa Loa (eye worm) hypothetical protein 0.0026 0.0035 0.0266
Leishmania major alpha tubulin 0.0264 0.0767 0.2842
Echinococcus multilocularis tubulin alpha 1C chain 0.0264 0.0767 0.0991
Schistosoma mansoni hypothetical protein 0.0046 0.0095 0.0154
Echinococcus multilocularis GPCR, family 2 0.0065 0.0156 0.0202
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0192 0.0546 0.0887
Loa Loa (eye worm) BEN-1 protein 0.0142 0.0392 0.3022
Onchocerca volvulus 0.0041 0.008 0.008
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.005 0.0108 0.0301
Echinococcus multilocularis short transient receptor potential channel 6 0.0067 0.016 0.0206
Onchocerca volvulus 0.0272 0.0791 0.0791
Echinococcus multilocularis tubulin alpha chain 0.0264 0.0767 0.0991
Entamoeba histolytica hypothetical protein 0.004 0.0079 0.1026
Giardia lamblia Telomerase catalytic subunit 0.0894 0.2699 1
Leishmania major beta tubulin 0.0142 0.0392 0.1453
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0192 0.0546 0.0705
Entamoeba histolytica hypothetical protein 0.004 0.0079 0.1026
Trichomonas vaginalis tubulin, putative 0.0142 0.0392 0.5112
Onchocerca volvulus 0.0272 0.0791 0.0791
Giardia lamblia Alpha-tubulin 0.0264 0.0767 0.2781
Schistosoma mansoni hypothetical protein 0.0171 0.0481 0.0781
Loa Loa (eye worm) ShTK domain-containing protein 0.0272 0.0791 0.6094
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0062 0.0145 0.0537
Echinococcus multilocularis Tubulin alpha 1 chain 0.0264 0.0767 0.0991
Entamoeba histolytica tubulin alpha chain, putative 0.0264 0.0767 1
Onchocerca volvulus 0.0041 0.008 0.008
Schistosoma mansoni tubulin subunit beta 0.0142 0.0392 0.0637
Loa Loa (eye worm) tubulin alpha 2 0.0122 0.033 0.2544
Mycobacterium tuberculosis 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) 0.0308 0.0899 0.2701
Treponema pallidum cell division protein FtsZ 0.0062 0.0145 0.5
Schistosoma mansoni cpg binding protein 0.006 0.014 0.0227
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0894 0.2699 1
Brugia malayi hypothetical protein 0.004 0.0079 0.0108
Trichomonas vaginalis tubulin beta chain, putative 0.0264 0.0767 1
Plasmodium vivax telomerase reverse transcriptase, putative 0.0894 0.2699 1
Leishmania major beta tubulin 0.0142 0.0392 0.1453
Brugia malayi tubulin alpha-2 chain 0.0264 0.0767 0.1057
Loa Loa (eye worm) hypothetical protein 0.0272 0.0791 0.6094
Loa Loa (eye worm) hypothetical protein 0.0037 0.0069 0.0534
Echinococcus granulosus tubulin alpha 1C chain 0.0264 0.0767 0.1246
Entamoeba histolytica fatty acid elongase, putative 0.004 0.0078 0.1014
Leishmania major 4-coumarate:coa ligase-like protein 0.005 0.0108 0.04
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0065 0.0156 0.0254
Loa Loa (eye worm) hypothetical protein 0.0264 0.0767 0.5911
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0023 0.0085
Loa Loa (eye worm) hypothetical protein 0.0017 0.0008 0.0065
Loa Loa (eye worm) hypothetical protein 0.0083 0.0211 0.1624
Echinococcus granulosus tubulin alpha chain 0.0264 0.0767 0.1246
Leishmania major beta tubulin 0.0142 0.0392 0.1453
Trypanosoma brucei beta tubulin 0.0142 0.0392 0.1453
Loa Loa (eye worm) hypothetical protein 0.011 0.0293 0.2259
Echinococcus granulosus tubulin alpha chain 0.0264 0.0767 0.1246
Trichomonas vaginalis tubulin beta chain, putative 0.0264 0.0767 1
Loa Loa (eye worm) hypothetical protein 0.0184 0.052 0.4006
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0034 0.0058 0.0216
Plasmodium vivax importin-beta 2, putative 0.003 0.0047 0.0175
Toxoplasma gondii histone lysine methyltransferase SET1 0.0108 0.0286 0.1061
Leishmania major alpha tubulin 0.0264 0.0767 0.2842
Leishmania major beta tubulin 0.0142 0.0392 0.1453
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0062 0.0145 0.0537
Echinococcus granulosus Tubulin beta 2C chain 0.0142 0.0392 0.0637
Echinococcus multilocularis dnaJ subfamily B 0.0811 0.2445 0.3158
Entamoeba histolytica tubulin family protein 0.0142 0.0392 0.5112
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0036 0.0132
Loa Loa (eye worm) hypothetical protein 0.0083 0.0211 0.1624
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0272 0.0791 0.109
Brugia malayi Tubulin alpha-2 chain 0.0264 0.0767 0.1057
Loa Loa (eye worm) hypothetical protein 0.005 0.0108 0.0831
Brugia malayi AMP-binding enzyme family protein 0.005 0.0108 0.0149
Onchocerca volvulus 0.005 0.0108 0.0108
Plasmodium vivax tubulin alpha chain, putative 0.0264 0.0767 0.2842
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0083 0.0211 0.0781
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0036 0.0132
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0036 0.005
Leishmania major beta tubulin 0.0142 0.0392 0.1453
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0207 0.0591 0.0814
Brugia malayi Common central domain of tyrosinase family protein 0.0272 0.0791 0.109
Loa Loa (eye worm) hypothetical protein 0.0023 0.0027 0.0206
Loa Loa (eye worm) hypothetical protein 0.0037 0.0069 0.0534
Brugia malayi hypothetical protein 0.0017 0.0007 0.001
Loa Loa (eye worm) hypothetical protein 0.0037 0.007 0.0542
Echinococcus granulosus Niemann Pick C1 protein 0.0157 0.0438 0.0712
Plasmodium falciparum tubulin epsilon chain, putative 0.0142 0.0392 0.1453
Plasmodium vivax acyl-CoA synthetase, putative 0.0037 0.0069 0.0257
Echinococcus granulosus neuropeptide s receptor 0.0451 0.1341 0.2178
Plasmodium falciparum tubulin gamma chain 0.0142 0.0392 0.1453
Trichomonas vaginalis ran, putative 0.0022 0.0023 0.0298
Onchocerca volvulus 0.0272 0.0791 0.0791
Onchocerca volvulus 0.0026 0.0036 0.0036
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0174 0.0283
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0063 0.0189
Trypanosoma brucei tubulin gamma chain 0.0142 0.0392 0.1453
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0034 0.0058 0.0095
Trypanosoma brucei telomerase reverse transcriptase 0.0894 0.2699 1
Loa Loa (eye worm) LBP/BPI/CETP family domain-containing protein 0.0041 0.008 0.0616
Schistosoma mansoni alpha tubulin 0.0264 0.0767 0.1246
Toxoplasma gondii alpha-tubulin I, putative 0.0264 0.0767 0.2842
Loa Loa (eye worm) hypothetical protein 0.0101 0.0265 0.2039
Trichomonas vaginalis tubulin gamma chain, putative 0.0142 0.0392 0.5112
Brugia malayi LBP / BPI / CETP family, C-terminal domain containing protein 0.0041 0.008 0.011
Trypanosoma cruzi epsilon tubulin, putative 0.0142 0.0392 0.1453
Echinococcus multilocularis 0.0083 0.0211 0.0272
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0174 0.0283
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.01 0.1306
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0023 0.0031
Entamoeba histolytica acyl-coA synthetase, putative 0.005 0.0108 0.1406
Brugia malayi RNA recognition motif domain containing protein 0.0071 0.0174 0.024
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0023 0.0085
Schistosoma mansoni tubulin subunit epsilon 0.0142 0.0392 0.0637
Loa Loa (eye worm) hypothetical protein 0.0272 0.0791 0.6094
Echinococcus multilocularis tubulin alpha 3 chain 0.0264 0.0767 0.0991
Leishmania major beta tubulin 0.0142 0.0392 0.1453
Brugia malayi LBP/BPI 0.0017 0.0008 0.0012
Brugia malayi Hypothetical tyrosinase-like protein F21C3.2 in chromosome I 0.0272 0.0791 0.109
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.0311 0.24
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0108 0.0324
Onchocerca volvulus 0.0017 0.0008 0.0008
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0062 0.0145 0.1889
Trypanosoma cruzi tubulin delta chain 0.0062 0.0145 0.0537
Trichomonas vaginalis tubulin epsilon chain, putative 0.0264 0.0767 1
Echinococcus granulosus alpha tubulin 0.0264 0.0767 0.1246
Echinococcus granulosus snurportin 1 0.032 0.0937 0.1521
Schistosoma mansoni hypothetical protein 0.0065 0.0156 0.0254
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.032 0.0937 0.7218
Echinococcus multilocularis Tubulin beta 2C chain 0.0142 0.0392 0.0506
Echinococcus granulosus tubulin delta chain 0.0062 0.0145 0.0235
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.005 0.0108 0.5115
Echinococcus granulosus Tubulin beta 2C chain 0.0142 0.0392 0.0637
Echinococcus multilocularis muscleblind protein 1 0.0437 0.1298 0.1676
Echinococcus granulosus Tubulin alpha 1 chain 0.0264 0.0767 0.1246
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0065 0.0156 0.0202
Echinococcus granulosus Tubulin alpha 1 chain 0.0264 0.0767 0.1246
Trypanosoma brucei epsilon tubulin 0.0142 0.0392 0.1453
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0192 0.0546 0.0887
Brugia malayi alpha-tubulin 0.0264 0.0767 0.1057
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0087 0.0221 0.0821
Brugia malayi LBP / BPI / CETP family, N-terminal domain containing protein 0.0041 0.008 0.011
Plasmodium vivax hypothetical protein, conserved 0.0083 0.0211 0.0781
Giardia lamblia Beta tubulin 0.0142 0.0392 0.138
Onchocerca volvulus 0.0272 0.0791 0.0791
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0108 0.0301
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0063 0.0189
Loa Loa (eye worm) tubulin alpha-3 chain 0.0184 0.052 0.4006
Giardia lamblia Epsilon tubulin 0.0062 0.0145 0.0456
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0192 0.0546 0.0887
Schistosoma mansoni transient receptor potential channel 0.0101 0.0265 0.043
Toxoplasma gondii hypothetical protein 0.0049 0.0106 0.0394
Loa Loa (eye worm) BEN-1 protein 0.0142 0.0392 0.3022
Chlamydia trachomatis oxoacyl-ACP synthase III 0.0308 0.0899 1
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0036 0.0278
Loa Loa (eye worm) hypothetical protein 0.0017 0.0008 0.0065
Loa Loa (eye worm) tubulin alpha-2 chain 0.0264 0.0767 0.5911
Loa Loa (eye worm) tubulin gamma chain 0.0142 0.0392 0.3022
Schistosoma mansoni cpg binding protein 0.006 0.014 0.0227
Schistosoma mansoni tubulin subunit gamma 0.0142 0.0392 0.0637
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0052 0.0116 0.0429
Loa Loa (eye worm) hypothetical protein 0.0437 0.1298 1
Plasmodium falciparum telomerase reverse transcriptase 0.0894 0.2699 1
Leishmania major alpha tubulin 0.0264 0.0767 0.2842
Leishmania major beta tubulin 0.0142 0.0392 0.1453
Echinococcus granulosus tubulin beta 4A class IVa 0.0142 0.0392 0.0637
Echinococcus multilocularis peroxisome assembly protein 26 0.0264 0.0767 0.0991
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.0308 0.0899 1
Trypanosoma cruzi tubulin gamma chain 0.0142 0.0392 0.1453
Mycobacterium ulcerans fatty-acid-CoA ligase 0.005 0.0108 0.0301
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0083 0.0211 0.0781
Echinococcus multilocularis neuropeptide receptor A26 0.0451 0.1341 0.1732
Mycobacterium ulcerans cell division protein FtsZ 0.0062 0.0145 0.0404
Leishmania major alpha tubulin 0.0264 0.0767 0.2842
Trypanosoma brucei beta tubulin 0.0142 0.0392 0.1453
Echinococcus granulosus microtubule associated protein 2 0.202 0.6157 1
Brugia malayi Augmenter of liver regeneration 0.0034 0.0058 0.008
Echinococcus granulosus intermediate filament protein 0.0026 0.0036 0.0058
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0083 0.0211 1
Brugia malayi Cell division protein ftsZ 0.0062 0.0145 0.02
Echinococcus granulosus Niemann Pick C1 protein 0.011 0.0293 0.0476
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0065 0.0156 0.0202
Brugia malayi Tubulin beta chain 0.0081 0.0202 0.0279
Loa Loa (eye worm) hypothetical protein 0.0058 0.0133 0.1024
Loa Loa (eye worm) tubulin alpha 2 0.0203 0.0577 0.4449
Trichomonas vaginalis tubulin, putative 0.0081 0.0202 0.2639
Trichomonas vaginalis tubulin epsilon chain, putative 0.0142 0.0392 0.5112
Echinococcus granulosus muscleblind protein 0.0437 0.1298 0.2108
Leishmania major delta tubulin, putative 0.0062 0.0145 0.0537
Echinococcus granulosus tar DNA binding protein 0.0071 0.0174 0.0283
Loa Loa (eye worm) tyrosinase 1 0.0272 0.0791 0.6094
Echinococcus granulosus lamin dm0 0.0026 0.0036 0.0058
Loa Loa (eye worm) tubulin alpha chain 0.0264 0.0767 0.5911
Loa Loa (eye worm) tubulin beta chain 0.0062 0.0145 0.1117
Echinococcus granulosus Tubulin beta 2C chain 0.0142 0.0392 0.0637
Echinococcus granulosus importin subunit beta 1 0.003 0.0047 0.0077
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0207 0.0591 0.4551
Trichomonas vaginalis importin beta-1, putative 0.0024 0.003 0.0388
Echinococcus granulosus short transient receptor potential channel 6 0.0067 0.016 0.026
Schistosoma mansoni tubulin subunit beta 0.0142 0.0392 0.0637
Schistosoma mansoni hypothetical protein 0.0046 0.0095 0.0154
Loa Loa (eye worm) beta-tubulin 0.0142 0.0392 0.3022
Echinococcus multilocularis tubulin alpha chain 0.0264 0.0767 0.0991
Toxoplasma gondii RNA-directed DNA polymerase 0.0894 0.2699 1
Loa Loa (eye worm) hypothetical protein 0.0083 0.0211 0.1624
Echinococcus granulosus tubulin subunit TubB 0.0264 0.0767 0.1246
Leishmania major alpha tubulin 0.0264 0.0767 0.2842
Brugia malayi Importin beta-1 subunit 0.003 0.0047 0.0065
Brugia malayi Latrophilin receptor protein 2 0.0065 0.0156 0.0215
Trichomonas vaginalis tubulin gamma chain, putative 0.0062 0.0145 0.1889
Trichomonas vaginalis tubulin epsilon chain, putative 0.0062 0.0145 0.1889
Onchocerca volvulus 0.0041 0.008 0.008
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0144 0.0398 0.1476
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.011 0.0293 0.3821
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0034 0.0058 0.0216
Echinococcus granulosus tubulin epsilon chain 0.0142 0.0392 0.0637
Echinococcus multilocularis Tubulin beta 2C chain 0.0142 0.0392 0.0506
Entamoeba histolytica acyl-CoA synthetase, putative 0.005 0.0108 0.1406
Echinococcus multilocularis Niemann Pick C1 protein 0.011 0.0293 0.0379
Schistosoma mansoni transient receptor potential channel 0.0067 0.016 0.026
Loa Loa (eye worm) tubulin alpha chain 0.0264 0.0767 0.5911
Plasmodium falciparum alpha tubulin 1 0.0264 0.0767 0.2842
Plasmodium vivax delta tubulin, putative 0.0062 0.0145 0.0537
Leishmania major zeta tubulin, putative 0.0062 0.0145 0.0537
Schistosoma mansoni tubulin subunit beta 0.0142 0.0392 0.0637
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0305 0.0892 0.3304
Leishmania major alpha tubulin 0.0264 0.0767 0.2842
Loa Loa (eye worm) hypothetical protein 0.0083 0.0211 0.1624
Onchocerca volvulus 0.0041 0.008 0.008
Echinococcus granulosus Tubulin beta 2C chain 0.0142 0.0392 0.0637
Loa Loa (eye worm) hypothetical protein 0.0037 0.0069 0.0534
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0018 0.0009 0.0012
Echinococcus multilocularis short transient receptor potential channel 6 0.0067 0.016 0.0206
Loa Loa (eye worm) hypothetical protein 0.0037 0.0069 0.0534
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0083 0.0211 0.0781
Echinococcus granulosus TRP transient receptor potential channel 0.0037 0.007 0.0114
Loa Loa (eye worm) tubulin beta-2A chain 0.0142 0.0392 0.3022
Schistosoma mansoni tubulin subunit delta 0.0062 0.0145 0.0235
Loa Loa (eye worm) alpha-tubulin 0.0264 0.0767 0.5911
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0081 0.0202 0.2639
Echinococcus multilocularis microtubule associated protein 2 0.202 0.6157 0.7951
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0083 0.0211 0.0342
Brugia malayi hypothetical protein 0.0017 0.0008 0.0012
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0037 0.0069 0.0193
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0192 0.0546 0.4208
Toxoplasma gondii alpha tubulin TUBA1 0.0264 0.0767 0.2842
Echinococcus granulosus tubulin beta 1 chain 0.0142 0.0392 0.0637
Leishmania major beta tubulin 0.0142 0.0392 0.1453
Loa Loa (eye worm) tubulin beta chain 0.0142 0.0392 0.3022
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0036 0.0132
Brugia malayi TAR-binding protein 0.0071 0.0174 0.024
Trichomonas vaginalis tubulin gamma chain, putative 0.0142 0.0392 0.5112
Leishmania major alpha tubulin 0.0264 0.0767 0.2842
Leishmania major alpha tubulin 0.0264 0.0767 0.2842
Leishmania major beta tubulin 0.0142 0.0392 0.1453
Trichomonas vaginalis tubulin, putative 0.0062 0.0145 0.1889
Leishmania major telomerase reverse transcriptase, putative 0.0894 0.2699 1
Echinococcus multilocularis snurportin 1 0.032 0.0937 0.121
Brugia malayi CHE-14 protein 0.0047 0.01 0.0138
Brugia malayi hypothetical protein 0.0023 0.0027 0.0037
Brugia malayi CXXC zinc finger family protein 0.0057 0.013 0.0179
Giardia lamblia Alpha-tubulin 0.0264 0.0767 0.2781
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0079 0.0128
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0047 0.01 0.0772
Onchocerca volvulus 0.0026 0.0036 0.0036
Schistosoma mansoni hypothetical protein 0.0065 0.0156 0.0254
Echinococcus granulosus tubulin alpha chain 0.0264 0.0767 0.1246
Trypanosoma cruzi beta tubulin, putative 0.0142 0.0392 0.1453
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0047 0.0175
Trichomonas vaginalis tubulin gamma chain, putative 0.0142 0.0392 0.5112
Leishmania major beta tubulin 0.0142 0.0392 0.1453
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0034 0.0058 0.0216
Onchocerca volvulus 0.0081 0.0202 0.0202
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0112 0.0298 0.0485
Schistosoma mansoni tubulin subunit alpha 0.0264 0.0767 0.1246
Entamoeba histolytica fatty acid elongase, putative 0.004 0.0078 0.1014
Brugia malayi SWIRM domain containing protein 0.0083 0.0211 0.0291
Echinococcus granulosus beta tubulin 0.0142 0.0392 0.0637
Toxoplasma gondii beta tubulin 0.0142 0.0392 0.1453
Mycobacterium ulcerans beta-ketoacyl synthase-like protein 0.0308 0.0899 0.2509
Brugia malayi Tubulin alpha-2 chain 0.0264 0.0767 0.1057
Loa Loa (eye worm) alpha-tubulin 0.0264 0.0767 0.5911
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0305 0.0892 0.3304
Brugia malayi tubulin alpha chain - mouse 0.0264 0.0767 0.1057
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0018 0.0009 0.0015
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0264 0.0767 1
Echinococcus multilocularis lamin dm0 0.0026 0.0036 0.0047
Echinococcus granulosus tubulin alpha 3 chain 0.0264 0.0767 0.1246
Echinococcus granulosus dnaJ subfamily B 0.0811 0.2445 0.3971
Loa Loa (eye worm) hypothetical protein 0.0023 0.0027 0.0206
Leishmania major alpha tubulin 0.0264 0.0767 0.2842
Entamoeba histolytica hypothetical protein 0.004 0.0079 0.1026
Brugia malayi Muscleblind-like protein 0.0437 0.1298 0.1788
Toxoplasma gondii histone lysine-specific demethylase 0.0083 0.0211 0.0781
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0043 0.0087 0.0322
Leishmania major epsilon tubulin, putative 0.0142 0.0392 0.1453
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.2536 0.7743 1
Leishmania major beta tubulin 0.0142 0.0392 0.1453
Loa Loa (eye worm) LBP/BPI/CETP family domain-containing protein 0.0023 0.0027 0.0206
Mycobacterium tuberculosis Conserved hypothetical protein 0.0083 0.0211 0.0633
Brugia malayi Telomerase reverse transcriptase 0.2378 0.7256 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.003 0.0388
Loa Loa (eye worm) hypothetical protein 0.012 0.0323 0.2492
Entamoeba histolytica fatty acid elongase, putative 0.004 0.0078 0.1014
Trypanosoma brucei beta tubulin 0.0142 0.0392 0.1453
Schistosoma mansoni importin beta-1 0.003 0.0047 0.0077
Mycobacterium ulcerans hypothetical protein 0.0161 0.0449 0.1251
Trypanosoma cruzi zeta tubulin, putative 0.0062 0.0145 0.0537
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0043 0.0087 0.0322
Loa Loa (eye worm) hypothetical protein 0.0063 0.015 0.1152
Brugia malayi Calcitonin receptor-like protein seb-1 0.0207 0.0591 0.0814
Leishmania major beta tubulin 0.0142 0.0392 0.1453
Trypanosoma cruzi UDP-galactopyranose mutase 0.0083 0.0211 0.0781
Trichomonas vaginalis tubulin alpha chain, putative 0.0142 0.0392 0.5112
Echinococcus multilocularis tubulin subunit TubB 0.0264 0.0767 0.0991
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0047 0.0175
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0203 0.0577 0.4449
Loa Loa (eye worm) hypothetical protein 0.0041 0.008 0.0616
Leishmania major alpha tubulin 0.0264 0.0767 0.2842
Schistosoma mansoni hypothetical protein 0.0046 0.0095 0.0154
Brugia malayi beta-tubulin, identical 0.0142 0.0392 0.054
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0121 0.0326 0.0529
Trypanosoma brucei epsilon tubulin 0.0142 0.0392 0.1453
Mycobacterium tuberculosis Possible oxidoreductase 0.0083 0.0211 0.0633
Schistosoma mansoni lamin 0.0026 0.0036 0.0058
Loa Loa (eye worm) hypothetical protein 0.0047 0.01 0.0772
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0308 0.0899 0.2509
Echinococcus multilocularis tubulin subunit beta 0.0142 0.0392 0.0506
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0037 0.007 0.0091
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0184 0.052 0.6777
Loa Loa (eye worm) hypothetical protein 0.005 0.0108 0.0831
Loa Loa (eye worm) hypothetical protein 0.0141 0.039 0.3002
Leishmania major hypothetical protein, conserved 0.0034 0.0058 0.0216
Echinococcus multilocularis neuropeptide s receptor 0.0451 0.1341 0.1732
Toxoplasma gondii beta-1 tubulin, putative 0.0142 0.0392 0.1453
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0144 0.0398 0.1476
Loa Loa (eye worm) tubulin beta-4 chain 0.0142 0.0392 0.3022
Echinococcus granulosus tubulin alpha chain 0.0264 0.0767 0.1246
Echinococcus multilocularis cpg binding protein 0.006 0.014 0.0181
Leishmania major gamma-tubulin 0.0142 0.0392 0.1453
Brugia malayi hypothetical protein 0.012 0.0323 0.0446
Entamoeba histolytica hypothetical protein 0.004 0.0079 0.1026
Brugia malayi RNA binding protein 0.0071 0.0174 0.024
Echinococcus multilocularis Niemann Pick C1 protein 0.0157 0.0438 0.0566
Trichomonas vaginalis tubulin beta chain, putative 0.0264 0.0767 1
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0174 0.0283
Echinococcus multilocularis tubulin alpha 0.0142 0.0392 0.0506
Leishmania major beta tubulin 0.0142 0.0392 0.1453
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0065 0.0156 0.0215
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0174 0.0283
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.005 0.0108 0.0301
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0272 0.0791 0.109
Entamoeba histolytica tubulin alpha-1 chain 0.0264 0.0767 1
Loa Loa (eye worm) TAR-binding protein 0.0071 0.0174 0.1342
Trypanosoma brucei epsilon tubulin 0.0142 0.0392 0.1453
Trichomonas vaginalis tubulin epsilon chain, putative 0.0142 0.0392 0.5112
Onchocerca volvulus 0.0041 0.008 0.008
Schistosoma mansoni ran 0.0022 0.0023 0.0037
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0023 0.0085
Trypanosoma brucei alpha tubulin 0.0264 0.0767 0.2842
Schistosoma mansoni hypothetical protein 0.0065 0.0156 0.0254
Entamoeba histolytica Ran family GTPase 0.0022 0.0023 0.0298
Plasmodium vivax hypothetical protein, conserved 0.0083 0.0211 0.0781
Loa Loa (eye worm) hypothetical protein 0.012 0.0323 0.2492
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.1182 0.3585 1
Trichomonas vaginalis tubulin beta chain, putative 0.0081 0.0202 0.2639
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0047 0.0175
Mycobacterium tuberculosis Cell division protein FtsZ 0.0062 0.0145 0.0435
Loa Loa (eye worm) hypothetical protein 0.0207 0.0591 0.4551
Loa Loa (eye worm) hypothetical protein 0.0017 0.0008 0.0065
Loa Loa (eye worm) hypothetical protein 0.0437 0.1298 1
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0036 0.0132
Echinococcus granulosus lysine specific histone demethylase 1A 0.0083 0.0211 0.0342
Schistosoma mansoni cpg binding protein 0.0057 0.013 0.0211
Loa Loa (eye worm) histone methyltransferase 0.0018 0.0009 0.0071
Schistosoma mansoni alpha tubulin 0.0264 0.0767 0.1246
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.1182 0.3585 1
Leishmania major beta tubulin 0.0142 0.0392 0.1453
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.0311 0.24
Echinococcus multilocularis tubulin alpha chain 0.0264 0.0767 0.0991
Mycobacterium ulcerans dehydrogenase 0.0083 0.0211 0.0588
Schistosoma mansoni ran 0.0022 0.0023 0.0037
Echinococcus multilocularis Tubulin alpha 1 chain 0.0264 0.0767 0.0991
Echinococcus granulosus short transient receptor potential channel 6 0.0067 0.016 0.026
Echinococcus granulosus Tubulin alpha 1 chain 0.0264 0.0767 0.1246
Echinococcus multilocularis Tubulin beta 2C chain 0.0142 0.0392 0.0506
Leishmania major UDP-galactopyranose mutase 0.0083 0.0211 0.0781
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0023 0.0085
Schistosoma mansoni tubulin subunit beta 0.0142 0.0392 0.0637
Echinococcus granulosus geminin 0.0171 0.0481 0.0781
Brugia malayi hypothetical protein 0.0083 0.0211 0.0291
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0144 0.0398 0.1476
Echinococcus multilocularis beta tubulin 0.0142 0.0392 0.0506
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.1099 0.3329 1
Trypanosoma brucei zeta tubulin 0.0062 0.0145 0.0537
Toxoplasma gondii Erv1 / Alr family protein 0.0034 0.0058 0.0216
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.003 0.0388
Brugia malayi amine oxidase, flavin-containing family protein 0.0083 0.0211 0.0291
Echinococcus granulosus expressed conserved protein 0.0103 0.0273 0.0443
Loa Loa (eye worm) hypothetical protein 0.0023 0.0027 0.0206
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0192 0.0546 0.0705
Brugia malayi LBP / BPI / CETP family, C-terminal domain containing protein 0.0023 0.0027 0.0037
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0192 0.0546 0.0753
Loa Loa (eye worm) hypothetical protein 0.003 0.0047 0.0363
Echinococcus granulosus tubulin alpha 0.0142 0.0392 0.0637
Echinococcus granulosus Tubulin beta 2C chain 0.0142 0.0392 0.0637
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.003 0.011
Loa Loa (eye worm) LBP/BPI/CETP family domain-containing protein 0.0023 0.0027 0.0206
Schistosoma mansoni hypothetical protein 0.0811 0.2445 0.3971
Loa Loa (eye worm) hepatopoietin HPO2 0.0034 0.0058 0.0449
Echinococcus multilocularis transient receptor potential ion channel A 0.0097 0.0254 0.0328
Mycobacterium tuberculosis Conserved hypothetical protein 0.0161 0.0449 0.1347
Echinococcus multilocularis tubulin beta 1 chain 0.0142 0.0392 0.0506
Mycobacterium ulcerans oxidoreductase 0.0083 0.0211 0.0588
Echinococcus multilocularis importin subunit beta 1 0.003 0.0047 0.0061
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0142 0.0392 0.1453
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0036 0.0278
Loa Loa (eye worm) hypothetical protein 0.0083 0.0211 0.1624
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0034 0.0058 0.0075
Echinococcus granulosus Protein patched homolog 1 0.0047 0.01 0.0163
Echinococcus multilocularis tubulin gamma 1 chain 0.0142 0.0392 0.0506
Echinococcus multilocularis protoporphyrinogen oxidase 0.0083 0.0211 0.0272
Loa Loa (eye worm) hypothetical protein 0.0026 0.0036 0.0274
Brugia malayi hypothetical protein 0.0026 0.0036 0.0049
Trypanosoma brucei zeta tubulin, putative 0.0062 0.0145 0.0537
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0036 0.0132
Onchocerca volvulus 0.0083 0.0211 0.0211
Schistosoma mansoni hypothetical protein 0.0141 0.039 0.0633
Echinococcus multilocularis tar DNA binding protein 0.0071 0.0174 0.0225
Brugia malayi intermediate filament protein 0.0026 0.0036 0.005
Schistosoma mansoni transient receptor potential channel 4 0.0101 0.0265 0.043
Brugia malayi LBP / BPI / CETP family, C-terminal domain containing protein 0.0023 0.0027 0.0037
Onchocerca volvulus 0.0041 0.008 0.008
Echinococcus multilocularis sterol regulatory element binding protein 0.0047 0.01 0.0129
Echinococcus multilocularis protein dispatched 1 0.0054 0.0121 0.0156
Echinococcus multilocularis transient receptor potential gamma protein 0.0101 0.0265 0.0342
Onchocerca volvulus 0.0041 0.008 0.008
Schistosoma mansoni patched 1 0.0047 0.01 0.0163
Trypanosoma cruzi zeta tubulin, putative 0.0062 0.0145 0.0537
Schistosoma mansoni amine oxidase 0.0083 0.0211 0.0342
Leishmania major 4-coumarate:coa ligase-like protein 0.005 0.0108 0.04
Trichomonas vaginalis tubulin epsilon chain, putative 0.0264 0.0767 1
Loa Loa (eye worm) RNA binding protein 0.0071 0.0174 0.1342
Schistosoma mansoni intermediate filament proteins 0.0026 0.0036 0.0058
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0203 0.0577 0.7527
Echinococcus multilocularis tubulin alpha 3 chain 0.0264 0.0767 0.0991
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0034 0.0058 0.0216
Onchocerca volvulus 0.0041 0.008 0.008
Schistosoma mansoni hypothetical protein 0.004 0.0079 0.0128
Schistosoma mansoni tyrosinase precursor 0.0272 0.0791 0.1284
Echinococcus multilocularis tubulin epsilon chain 0.0142 0.0392 0.0506
Trichomonas vaginalis tubulin beta chain, putative 0.0264 0.0767 1
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0083 0.0211 0.0342
Echinococcus granulosus sterol regulatory element binding protein 0.0047 0.01 0.0163
Plasmodium vivax tubulin beta chain, putative 0.0142 0.0392 0.1453
Leishmania major importin beta-1 subunit, putative 0.0024 0.003 0.011
Loa Loa (eye worm) hypothetical protein 0.0023 0.0027 0.0206
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0192 0.0546 0.0887
Mycobacterium ulcerans monoamine oxidase 0.0083 0.0211 0.0588
Trypanosoma brucei alpha tubulin 0.0264 0.0767 0.2842
Schistosoma mansoni hypothetical protein 0.0046 0.0095 0.0154
Brugia malayi LBP / BPI / CETP family, N-terminal domain containing protein 0.0041 0.008 0.011
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.005 0.0108 0.0301
Brugia malayi MH2 domain containing protein 0.0116 0.0311 0.0429
Schistosoma mansoni tubulin subunit beta 0.0142 0.0392 0.0637
Brugia malayi Tubulin beta-1 chain 0.0142 0.0392 0.054
Schistosoma mansoni tubulin subunit alpha 0.0264 0.0767 0.1246
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0023 0.0085
Leishmania major beta tubulin 0.0142 0.0392 0.1453
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0023 0.003
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0034 0.0058 0.0216
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0008 0.011
Leishmania major 4-coumarate:coa ligase-like protein 0.005 0.0108 0.04
Plasmodium falciparum protoporphyrinogen oxidase 0.0083 0.0211 0.0781
Brugia malayi Niemann-Pick C1 protein precursor 0.011 0.0293 0.0404
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0036 0.0132
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0305 0.0892 0.3304
Echinococcus multilocularis muscleblind protein 0.0437 0.1298 0.1676
Trichomonas vaginalis tubulin beta chain, putative 0.0264 0.0767 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0065 0.0156 0.1204
Brugia malayi Tubulin alpha chain 0.0264 0.0767 0.1057
Schistosoma mansoni microtubule-associated protein tau 0.202 0.6157 1
Echinococcus granulosus cpg binding protein 0.006 0.014 0.0227
Schistosoma mansoni tubulin subunit alpha 0.0062 0.0145 0.0235
Trypanosoma cruzi UDP-galactopyranose mutase 0.0083 0.0211 0.0781
Chlamydia trachomatis protoporphyrinogen oxidase 0.0083 0.0211 0.1705
Echinococcus granulosus neuropeptide receptor A26 0.0451 0.1341 0.2178
Leishmania major beta tubulin 0.0142 0.0392 0.1453
Leishmania major beta tubulin 0.0142 0.0392 0.1453
Echinococcus granulosus tubulin alpha chain 0.0264 0.0767 0.1246
Trypanosoma cruzi epsilon tubulin, putative 0.0142 0.0392 0.1453
Loa Loa (eye worm) CXXC zinc finger family protein 0.0057 0.013 0.1002
Plasmodium falciparum alpha tubulin 2 0.0264 0.0767 0.2842
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0894 0.2699 1
Echinococcus granulosus tubulin alpha 1C chain 0.0264 0.0767 0.1246
Leishmania major mitochondrial DNA polymerase beta 0.0305 0.0892 0.3304
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0023 0.0037
Echinococcus granulosus lamin 0.0026 0.0036 0.0058
Trichomonas vaginalis tubulin alpha chain, putative 0.0081 0.0202 0.2639
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0083 0.0211 0.0781
Mycobacterium leprae cell division protein FtsZ 0.0062 0.0145 0.6874
Trichomonas vaginalis tubulin alpha chain, putative 0.0081 0.0202 0.2639
Plasmodium falciparum importin beta, putative 0.003 0.0047 0.0175
Loa Loa (eye worm) hypothetical protein 0.0026 0.0036 0.0278
Echinococcus multilocularis hypothetical protein 0.0264 0.0767 0.0991
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0036 0.0132
Loa Loa (eye worm) hypothetical protein 0.0065 0.0156 0.1204
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0063 0.0189
Schistosoma mansoni transient receptor potential channel 0.0067 0.016 0.026
Echinococcus multilocularis Tubulin alpha 1 chain 0.0264 0.0767 0.0991
Loa Loa (eye worm) hypothetical protein 0.0037 0.0069 0.0534
Giardia lamblia Beta tubulin 0.0142 0.0392 0.138
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0087 0.0322
Brugia malayi Tubulin alpha chain 0.0062 0.0145 0.02
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0174 0.0283
Entamoeba histolytica tubulin family protein 0.0142 0.0392 0.5112
Toxoplasma gondii beta-tubulin, putative 0.0142 0.0392 0.1453
Echinococcus multilocularis tubulin delta chain 0.0062 0.0145 0.0187
Loa Loa (eye worm) hypothetical protein 0.0083 0.0211 0.1624
Loa Loa (eye worm) hypothetical protein 0.0203 0.0577 0.4449
Schistosoma mansoni hypothetical protein 0.0171 0.0481 0.0781
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0034 0.0058 0.0216
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0192 0.0546 0.0887
Echinococcus granulosus peroxisome assembly protein 26 0.0264 0.0767 0.1246
Echinococcus multilocularis Tubulin beta 2C chain 0.0142 0.0392 0.0506
Echinococcus granulosus tubulin alpha 3 chain 0.0264 0.0767 0.1246
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0108 0.0301
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0108 0.0301
Brugia malayi RNA, U transporter 1 0.0085 0.0217 0.0299
Entamoeba histolytica acyl-CoA synthetase, putative 0.005 0.0108 0.1406
Schistosoma mansoni tyrosinase precursor 0.0272 0.0791 0.1284
Echinococcus multilocularis Tubulin beta 2C chain 0.0142 0.0392 0.0506
Onchocerca volvulus Huntingtin homolog 0.012 0.0323 0.0323
Trypanosoma brucei tubulin delta chain 0.0062 0.0145 0.0537
Brugia malayi Tubulin gamma chain 0.0142 0.0392 0.054
Echinococcus multilocularis protein patched 0.0047 0.01 0.0129
Plasmodium vivax tubulin alpha chain, putative 0.0264 0.0767 0.2842
Echinococcus multilocularis lamin 0.0026 0.0036 0.0047
Echinococcus granulosus beta tubulin 0.0142 0.0392 0.0637
Brugia malayi Tubulin beta chain 0.0062 0.0145 0.02
Trichomonas vaginalis tubulin alpha chain, putative 0.0142 0.0392 0.5112
Loa Loa (eye worm) hypothetical protein 0.005 0.0108 0.0831
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0071 0.0174 0.1342
Trichomonas vaginalis tubulin beta chain, putative 0.0142 0.0392 0.5112
Echinococcus granulosus transient receptor potential gamma protein 0.0101 0.0265 0.043
Plasmodium vivax tubulin gamma chain, putative 0.0142 0.0392 0.1453
Entamoeba histolytica fatty acid elongase, putative 0.004 0.0078 0.1014
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0079 0.0128
Onchocerca volvulus 0.0023 0.0027 0.0027
Onchocerca volvulus 0.0057 0.013 0.013
Plasmodium falciparum beta-ketoacyl-ACP synthase III 0.0308 0.0899 0.3332
Leishmania major GTP-binding protein, putative 0.0022 0.0023 0.0085
Schistosoma mansoni amine oxidase 0.0083 0.0211 0.0342
Giardia lamblia Delta tubulin 0.0062 0.0145 0.0456
Loa Loa (eye worm) tubulin alpha 2 0.0203 0.0577 0.4449
Brugia malayi F/Y-rich N-terminus family protein 0.0017 0.0009 0.0012
Schistosoma mansoni lamin 0.0026 0.0036 0.0058
Echinococcus granulosus lysine specific histone demethylase 1A 0.0083 0.0211 0.0342
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0063 0.0189
Brugia malayi hypothetical protein 0.0023 0.0027 0.0037
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0145 0.1889
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0083 0.0211 0.0588

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 109 % Antiatherogenic activity in mouse human CETP/ApoA1 double transgenic model assessed as increase in HDL-c level at 30 mg/kg, po after 24 hrs relative to control ChEMBL. 22543028
IC50 (binding) = 29 nM Inhibition of CETP in human plasma assessed as transfer of fluorescently labelled cholesteryl ester to VLDL by fluorimetry ChEMBL. 22543028

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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