Detailed information for compound 1657048

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 681.596 | Formula: C29H32F9N7O2
  • H donors: 1 H acceptors: 4 LogP: 7.34 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 2
  • SMILES: NCCn1nnc(n1)N([C@H]1C[C@@H](C(C)C)N(c2c1cc(cc2)C(F)(F)F)C(=O)OC(C)C)Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F
  • InChi: 1S/C29H32F9N7O2/c1-15(2)23-13-24(21-12-18(27(30,31)32)5-6-22(21)45(23)26(46)47-16(3)4)43(25-40-42-44(41-25)8-7-39)14-17-9-19(28(33,34)35)11-20(10-17)29(36,37)38/h5-6,9-12,15-16,23-24H,7-8,13-14,39H2,1-4H3/t23-,24-/m0/s1
  • InChiKey: JCAHFVDJQHMHDN-ZEQRLZLVSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cholesteryl ester transfer protein, plasma Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni cpg binding protein 0.006 0.014 0.0227
Loa Loa (eye worm) tubulin alpha-2 chain 0.0264 0.0767 0.5911
Loa Loa (eye worm) tubulin gamma chain 0.0142 0.0392 0.3022
Loa Loa (eye worm) hypothetical protein 0.0017 0.0008 0.0065
Loa Loa (eye worm) BEN-1 protein 0.0142 0.0392 0.3022
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0036 0.0278
Chlamydia trachomatis oxoacyl-ACP synthase III 0.0308 0.0899 1
Schistosoma mansoni transient receptor potential channel 0.0101 0.0265 0.043
Toxoplasma gondii hypothetical protein 0.0049 0.0106 0.0394
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0192 0.0546 0.0887
Giardia lamblia Epsilon tubulin 0.0062 0.0145 0.0456
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0063 0.0189
Loa Loa (eye worm) tubulin alpha-3 chain 0.0184 0.052 0.4006
Giardia lamblia Beta tubulin 0.0142 0.0392 0.138
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0108 0.0301
Onchocerca volvulus 0.0272 0.0791 0.0791
Plasmodium vivax hypothetical protein, conserved 0.0083 0.0211 0.0781
Brugia malayi LBP / BPI / CETP family, N-terminal domain containing protein 0.0041 0.008 0.011
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0087 0.0221 0.0821
Brugia malayi alpha-tubulin 0.0264 0.0767 0.1057
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0083 0.0211 1
Echinococcus granulosus microtubule associated protein 2 0.202 0.6157 1
Echinococcus granulosus intermediate filament protein 0.0026 0.0036 0.0058
Brugia malayi Augmenter of liver regeneration 0.0034 0.0058 0.008
Mycobacterium ulcerans cell division protein FtsZ 0.0062 0.0145 0.0404
Leishmania major alpha tubulin 0.0264 0.0767 0.2842
Trypanosoma brucei beta tubulin 0.0142 0.0392 0.1453
Echinococcus multilocularis neuropeptide receptor A26 0.0451 0.1341 0.1732
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0083 0.0211 0.0781
Mycobacterium ulcerans fatty-acid-CoA ligase 0.005 0.0108 0.0301
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.0308 0.0899 1
Trypanosoma cruzi tubulin gamma chain 0.0142 0.0392 0.1453
Echinococcus granulosus tubulin beta 4A class IVa 0.0142 0.0392 0.0637
Echinococcus multilocularis peroxisome assembly protein 26 0.0264 0.0767 0.0991
Leishmania major alpha tubulin 0.0264 0.0767 0.2842
Leishmania major beta tubulin 0.0142 0.0392 0.1453
Plasmodium falciparum telomerase reverse transcriptase 0.0894 0.2699 1
Loa Loa (eye worm) hypothetical protein 0.0437 0.1298 1
Schistosoma mansoni tubulin subunit gamma 0.0142 0.0392 0.0637
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0052 0.0116 0.0429
Echinococcus granulosus snurportin 1 0.032 0.0937 0.1521
Echinococcus granulosus alpha tubulin 0.0264 0.0767 0.1246
Trypanosoma cruzi tubulin delta chain 0.0062 0.0145 0.0537
Trichomonas vaginalis tubulin epsilon chain, putative 0.0264 0.0767 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0108 0.0324
Onchocerca volvulus 0.0017 0.0008 0.0008
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0062 0.0145 0.1889
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.0311 0.24
Brugia malayi Hypothetical tyrosinase-like protein F21C3.2 in chromosome I 0.0272 0.0791 0.109
Echinococcus multilocularis tubulin alpha 3 chain 0.0264 0.0767 0.0991
Leishmania major beta tubulin 0.0142 0.0392 0.1453
Brugia malayi LBP/BPI 0.0017 0.0008 0.0012
Schistosoma mansoni tubulin subunit epsilon 0.0142 0.0392 0.0637
Loa Loa (eye worm) hypothetical protein 0.0272 0.0791 0.6094
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0023 0.0085
Brugia malayi RNA recognition motif domain containing protein 0.0071 0.0174 0.024
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0023 0.0031
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.01 0.1306
Entamoeba histolytica acyl-coA synthetase, putative 0.005 0.0108 0.1406
Trypanosoma cruzi epsilon tubulin, putative 0.0142 0.0392 0.1453
Echinococcus multilocularis 0.0083 0.0211 0.0272
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0174 0.0283
Brugia malayi LBP / BPI / CETP family, C-terminal domain containing protein 0.0041 0.008 0.011
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0192 0.0546 0.0887
Trypanosoma brucei epsilon tubulin 0.0142 0.0392 0.1453
Echinococcus granulosus Tubulin alpha 1 chain 0.0264 0.0767 0.1246
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0065 0.0156 0.0202
Echinococcus multilocularis muscleblind protein 1 0.0437 0.1298 0.1676
Echinococcus granulosus Tubulin alpha 1 chain 0.0264 0.0767 0.1246
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.005 0.0108 0.5115
Echinococcus granulosus Tubulin beta 2C chain 0.0142 0.0392 0.0637
Echinococcus granulosus tubulin delta chain 0.0062 0.0145 0.0235
Echinococcus multilocularis Tubulin beta 2C chain 0.0142 0.0392 0.0506
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.032 0.0937 0.7218
Schistosoma mansoni hypothetical protein 0.0065 0.0156 0.0254
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0018 0.0009 0.0012
Loa Loa (eye worm) hypothetical protein 0.0037 0.0069 0.0534
Echinococcus granulosus Tubulin beta 2C chain 0.0142 0.0392 0.0637
Onchocerca volvulus 0.0041 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.0083 0.0211 0.1624
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0305 0.0892 0.3304
Leishmania major alpha tubulin 0.0264 0.0767 0.2842
Plasmodium falciparum alpha tubulin 1 0.0264 0.0767 0.2842
Leishmania major zeta tubulin, putative 0.0062 0.0145 0.0537
Plasmodium vivax delta tubulin, putative 0.0062 0.0145 0.0537
Schistosoma mansoni tubulin subunit beta 0.0142 0.0392 0.0637
Echinococcus multilocularis Niemann Pick C1 protein 0.011 0.0293 0.0379
Schistosoma mansoni transient receptor potential channel 0.0067 0.016 0.026
Loa Loa (eye worm) tubulin alpha chain 0.0264 0.0767 0.5911
Echinococcus multilocularis Tubulin beta 2C chain 0.0142 0.0392 0.0506
Entamoeba histolytica acyl-CoA synthetase, putative 0.005 0.0108 0.1406
Echinococcus granulosus tubulin epsilon chain 0.0142 0.0392 0.0637
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.011 0.0293 0.3821
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0034 0.0058 0.0216
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0037 0.0069 0.0193
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0083 0.0211 0.0342
Brugia malayi hypothetical protein 0.0017 0.0008 0.0012
Echinococcus multilocularis microtubule associated protein 2 0.202 0.6157 0.7951
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0081 0.0202 0.2639
Loa Loa (eye worm) alpha-tubulin 0.0264 0.0767 0.5911
Schistosoma mansoni tubulin subunit delta 0.0062 0.0145 0.0235
Loa Loa (eye worm) tubulin beta-2A chain 0.0142 0.0392 0.3022
Echinococcus granulosus TRP transient receptor potential channel 0.0037 0.007 0.0114
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0083 0.0211 0.0781
Loa Loa (eye worm) hypothetical protein 0.0037 0.0069 0.0534
Echinococcus multilocularis short transient receptor potential channel 6 0.0067 0.016 0.0206
Trichomonas vaginalis importin beta-1, putative 0.0024 0.003 0.0388
Echinococcus granulosus short transient receptor potential channel 6 0.0067 0.016 0.026
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0207 0.0591 0.4551
Echinococcus granulosus importin subunit beta 1 0.003 0.0047 0.0077
Loa Loa (eye worm) tubulin beta chain 0.0062 0.0145 0.1117
Echinococcus granulosus Tubulin beta 2C chain 0.0142 0.0392 0.0637
Loa Loa (eye worm) tubulin alpha chain 0.0264 0.0767 0.5911
Echinococcus granulosus lamin dm0 0.0026 0.0036 0.0058
Loa Loa (eye worm) tyrosinase 1 0.0272 0.0791 0.6094
Leishmania major delta tubulin, putative 0.0062 0.0145 0.0537
Echinococcus granulosus tar DNA binding protein 0.0071 0.0174 0.0283
Echinococcus granulosus muscleblind protein 0.0437 0.1298 0.2108
Loa Loa (eye worm) tubulin alpha 2 0.0203 0.0577 0.4449
Trichomonas vaginalis tubulin epsilon chain, putative 0.0142 0.0392 0.5112
Trichomonas vaginalis tubulin, putative 0.0081 0.0202 0.2639
Loa Loa (eye worm) hypothetical protein 0.0058 0.0133 0.1024
Brugia malayi Tubulin beta chain 0.0081 0.0202 0.0279
Brugia malayi Cell division protein ftsZ 0.0062 0.0145 0.02
Echinococcus granulosus Niemann Pick C1 protein 0.011 0.0293 0.0476
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0065 0.0156 0.0202
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0144 0.0398 0.1476
Trichomonas vaginalis tubulin gamma chain, putative 0.0062 0.0145 0.1889
Trichomonas vaginalis tubulin epsilon chain, putative 0.0062 0.0145 0.1889
Onchocerca volvulus 0.0041 0.008 0.008
Brugia malayi Latrophilin receptor protein 2 0.0065 0.0156 0.0215
Brugia malayi Importin beta-1 subunit 0.003 0.0047 0.0065
Echinococcus granulosus tubulin subunit TubB 0.0264 0.0767 0.1246
Leishmania major alpha tubulin 0.0264 0.0767 0.2842
Loa Loa (eye worm) hypothetical protein 0.0083 0.0211 0.1624
Toxoplasma gondii RNA-directed DNA polymerase 0.0894 0.2699 1
Echinococcus multilocularis tubulin alpha chain 0.0264 0.0767 0.0991
Loa Loa (eye worm) beta-tubulin 0.0142 0.0392 0.3022
Schistosoma mansoni tubulin subunit beta 0.0142 0.0392 0.0637
Schistosoma mansoni hypothetical protein 0.0046 0.0095 0.0154
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0065 0.0156 0.0254
Trypanosoma brucei alpha tubulin 0.0264 0.0767 0.2842
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0272 0.0791 0.109
Trypanosoma cruzi tubulin delta chain 0.0062 0.0145 0.0537
Brugia malayi Transient-receptor-potential like protein 0.0037 0.007 0.0097
Toxoplasma gondii Erv1 / Alr family protein 0.0034 0.0058 0.0216
Giardia lamblia Beta tubulin 0.0142 0.0392 0.138
Echinococcus granulosus transient receptor potential ion channel A 0.0097 0.0254 0.0413
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0145 0.1889
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.005 0.0108 0.5115
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0023 0.0176
Schistosoma mansoni alpha tubulin 0.0264 0.0767 0.1246
Entamoeba histolytica tubulin gamma chain 0.0142 0.0392 0.5112
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.005 0.0108 0.0301
Onchocerca volvulus 0.0041 0.008 0.008
Loa Loa (eye worm) BEN-1 protein 0.0142 0.0392 0.3022
Schistosoma mansoni hypothetical protein 0.0046 0.0095 0.0154
Echinococcus multilocularis GPCR, family 2 0.0065 0.0156 0.0202
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0192 0.0546 0.0887
Leishmania major alpha tubulin 0.0264 0.0767 0.2842
Echinococcus multilocularis tubulin alpha 1C chain 0.0264 0.0767 0.0991
Loa Loa (eye worm) tubulin beta-1 chain 0.0142 0.0392 0.3022
Plasmodium falciparum tubulin delta chain, putative 0.0062 0.0145 0.0537
Loa Loa (eye worm) hypothetical protein 0.0026 0.0035 0.0266
Brugia malayi AMP-binding enzyme family protein 0.005 0.0108 0.0149
Giardia lamblia Gamma tubulin 0.0142 0.0392 0.138
Loa Loa (eye worm) hypothetical protein 0.0017 0.0008 0.0065
Echinococcus granulosus GPCR family 2 0.0065 0.0156 0.0254
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0023 0.0085
Echinococcus multilocularis tubulin alpha chain 0.0264 0.0767 0.0991
Brugia malayi LBP / BPI / CETP family, C-terminal domain containing protein 0.0023 0.0027 0.0037
Leishmania major alpha tubulin 0.0264 0.0767 0.2842
Entamoeba histolytica hypothetical protein 0.0024 0.003 0.0388
Echinococcus multilocularis tubulin alpha 1C chain 0.0264 0.0767 0.0991
Brugia malayi AMP-binding enzyme family protein 0.005 0.0108 0.0149
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0079 0.0102
Leishmania major hypothetical protein, conserved 0.0026 0.0036 0.0132
Brugia malayi ShTK domain containing protein 0.0272 0.0791 0.109
Entamoeba histolytica fatty acid elongase, putative 0.004 0.0078 0.1014
Plasmodium vivax tubulin epsilon chain, putative 0.0142 0.0392 0.1453
Plasmodium falciparum acyl-CoA synthetase 0.0037 0.0069 0.0257
Brugia malayi latrophilin 2 splice variant baaae 0.0141 0.039 0.0537
Schistosoma mansoni tubulin subunit beta 0.0142 0.0392 0.0637
Schistosoma mansoni hypothetical protein 0.0065 0.0156 0.0254
Plasmodium vivax beta-ketoacyl-acyl carrier protein synthase III precursor, putative 0.0308 0.0899 0.3332
Leishmania major alpha tubulin 0.0264 0.0767 0.2842
Mycobacterium ulcerans hypothetical protein 0.005 0.0108 0.0301
Onchocerca volvulus 0.0023 0.0027 0.0027
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0083 0.0211 0.0272
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0087 0.0322
Echinococcus multilocularis geminin 0.0171 0.0481 0.0621
Trichomonas vaginalis tubulin alpha chain, putative 0.0081 0.0202 0.2639
Plasmodium falciparum tubulin beta chain 0.0142 0.0392 0.1453
Echinococcus multilocularis beta tubulin 0.0142 0.0392 0.0506
Trypanosoma cruzi alpha tubulin, putative 0.0264 0.0767 0.2842
Echinococcus granulosus tubulin gamma 1 chain 0.0142 0.0392 0.0637
Schistosoma mansoni tubulin subunit alpha 0.0264 0.0767 0.1246
Loa Loa (eye worm) hypothetical protein 0.0034 0.006 0.0462
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0308 0.0899 0.2509
Loa Loa (eye worm) hypothetical protein 0.0023 0.0027 0.0206
Loa Loa (eye worm) ShTK domain-containing protein 0.0272 0.0791 0.6094
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0037 0.0069 0.0208
Leishmania major beta tubulin 0.0142 0.0392 0.1453
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.005 0.0108 0.0324
Schistosoma mansoni hypothetical protein 0.032 0.0937 0.1521
Echinococcus granulosus tubulin subunit beta 0.0142 0.0392 0.0637
Echinococcus multilocularis expressed conserved protein 0.0103 0.0273 0.0352
Schistosoma mansoni tubulin subunit beta 0.0062 0.0145 0.0235
Echinococcus multilocularis musashi 0.0026 0.0036 0.0047
Echinococcus multilocularis tubulin alpha chain 0.0264 0.0767 0.0991
Onchocerca volvulus Huntingtin homolog 0.012 0.0323 0.0323
Trypanosoma brucei beta tubulin 0.0142 0.0392 0.1453
Trypanosoma brucei alpha tubulin, putative 0.0081 0.0202 0.075
Trichomonas vaginalis tubulin beta chain, putative 0.0264 0.0767 1
Trypanosoma brucei beta tubulin 0.0142 0.0392 0.1453
Trichomonas vaginalis tubulin, putative 0.0081 0.0202 0.2639
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0142 0.0392 0.0506
Trypanosoma brucei alpha tubulin 0.0264 0.0767 0.2842
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0036 0.005
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0036 0.0132
Leishmania major beta tubulin 0.0142 0.0392 0.1453
Plasmodium vivax tubulin alpha chain, putative 0.0264 0.0767 0.2842
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0083 0.0211 0.0781
Onchocerca volvulus 0.005 0.0108 0.0108
Brugia malayi Tubulin alpha-2 chain 0.0264 0.0767 0.1057
Loa Loa (eye worm) hypothetical protein 0.005 0.0108 0.0831
Brugia malayi AMP-binding enzyme family protein 0.005 0.0108 0.0149
Loa Loa (eye worm) hypothetical protein 0.0083 0.0211 0.1624
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0036 0.0132
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0272 0.0791 0.109
Echinococcus multilocularis dnaJ subfamily B 0.0811 0.2445 0.3158
Entamoeba histolytica tubulin family protein 0.0142 0.0392 0.5112
Leishmania major beta tubulin 0.0142 0.0392 0.1453
Echinococcus granulosus Tubulin beta 2C chain 0.0142 0.0392 0.0637
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0062 0.0145 0.0537
Leishmania major alpha tubulin 0.0264 0.0767 0.2842
Toxoplasma gondii histone lysine methyltransferase SET1 0.0108 0.0286 0.1061
Loa Loa (eye worm) hypothetical protein 0.0184 0.052 0.4006
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0034 0.0058 0.0216
Plasmodium vivax importin-beta 2, putative 0.003 0.0047 0.0175
Trichomonas vaginalis tubulin beta chain, putative 0.0264 0.0767 1
Echinococcus granulosus tubulin alpha chain 0.0264 0.0767 0.1246
Trichomonas vaginalis tubulin gamma chain, putative 0.0142 0.0392 0.5112
Loa Loa (eye worm) hypothetical protein 0.0101 0.0265 0.2039
Schistosoma mansoni alpha tubulin 0.0264 0.0767 0.1246
Toxoplasma gondii alpha-tubulin I, putative 0.0264 0.0767 0.2842
Trypanosoma brucei telomerase reverse transcriptase 0.0894 0.2699 1
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0034 0.0058 0.0095
Loa Loa (eye worm) LBP/BPI/CETP family domain-containing protein 0.0041 0.008 0.0616
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0063 0.0189
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0174 0.0283
Trypanosoma brucei tubulin gamma chain 0.0142 0.0392 0.1453
Onchocerca volvulus 0.0026 0.0036 0.0036
Onchocerca volvulus 0.0272 0.0791 0.0791
Trichomonas vaginalis ran, putative 0.0022 0.0023 0.0298
Plasmodium falciparum tubulin gamma chain 0.0142 0.0392 0.1453
Echinococcus granulosus neuropeptide s receptor 0.0451 0.1341 0.2178
Plasmodium vivax acyl-CoA synthetase, putative 0.0037 0.0069 0.0257
Plasmodium falciparum tubulin epsilon chain, putative 0.0142 0.0392 0.1453
Loa Loa (eye worm) hypothetical protein 0.0037 0.007 0.0542
Brugia malayi hypothetical protein 0.0017 0.0007 0.001
Echinococcus granulosus Niemann Pick C1 protein 0.0157 0.0438 0.0712
Loa Loa (eye worm) hypothetical protein 0.0023 0.0027 0.0206
Loa Loa (eye worm) hypothetical protein 0.0037 0.0069 0.0534
Brugia malayi Common central domain of tyrosinase family protein 0.0272 0.0791 0.109
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0207 0.0591 0.0814
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0894 0.2699 1
Schistosoma mansoni cpg binding protein 0.006 0.014 0.0227
Brugia malayi hypothetical protein 0.004 0.0079 0.0108
Treponema pallidum cell division protein FtsZ 0.0062 0.0145 0.5
Mycobacterium tuberculosis 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) 0.0308 0.0899 0.2701
Loa Loa (eye worm) tubulin alpha 2 0.0122 0.033 0.2544
Schistosoma mansoni tubulin subunit beta 0.0142 0.0392 0.0637
Onchocerca volvulus 0.0041 0.008 0.008
Entamoeba histolytica tubulin alpha chain, putative 0.0264 0.0767 1
Echinococcus multilocularis Tubulin alpha 1 chain 0.0264 0.0767 0.0991
Onchocerca volvulus 0.0272 0.0791 0.0791
Schistosoma mansoni hypothetical protein 0.0171 0.0481 0.0781
Giardia lamblia Alpha-tubulin 0.0264 0.0767 0.2781
Trichomonas vaginalis tubulin, putative 0.0142 0.0392 0.5112
Loa Loa (eye worm) ShTK domain-containing protein 0.0272 0.0791 0.6094
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0062 0.0145 0.0537
Entamoeba histolytica hypothetical protein 0.004 0.0079 0.1026
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0192 0.0546 0.0705
Leishmania major beta tubulin 0.0142 0.0392 0.1453
Entamoeba histolytica hypothetical protein 0.004 0.0079 0.1026
Giardia lamblia Telomerase catalytic subunit 0.0894 0.2699 1
Echinococcus multilocularis short transient receptor potential channel 6 0.0067 0.016 0.0206
Echinococcus multilocularis tubulin alpha chain 0.0264 0.0767 0.0991
Onchocerca volvulus 0.0272 0.0791 0.0791
Loa Loa (eye worm) hypothetical protein 0.011 0.0293 0.2259
Trypanosoma brucei beta tubulin 0.0142 0.0392 0.1453
Echinococcus granulosus tubulin alpha chain 0.0264 0.0767 0.1246
Leishmania major beta tubulin 0.0142 0.0392 0.1453
Loa Loa (eye worm) hypothetical protein 0.0017 0.0008 0.0065
Loa Loa (eye worm) hypothetical protein 0.0083 0.0211 0.1624
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0023 0.0085
Loa Loa (eye worm) hypothetical protein 0.0264 0.0767 0.5911
Leishmania major 4-coumarate:coa ligase-like protein 0.005 0.0108 0.04
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0065 0.0156 0.0254
Echinococcus granulosus tubulin alpha 1C chain 0.0264 0.0767 0.1246
Entamoeba histolytica fatty acid elongase, putative 0.004 0.0078 0.1014
Loa Loa (eye worm) hypothetical protein 0.0037 0.0069 0.0534
Loa Loa (eye worm) hypothetical protein 0.0272 0.0791 0.6094
Brugia malayi tubulin alpha-2 chain 0.0264 0.0767 0.1057
Leishmania major beta tubulin 0.0142 0.0392 0.1453
Trichomonas vaginalis tubulin beta chain, putative 0.0264 0.0767 1
Plasmodium vivax telomerase reverse transcriptase, putative 0.0894 0.2699 1
Brugia malayi MH2 domain containing protein 0.0116 0.0311 0.0429
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.005 0.0108 0.0301
Brugia malayi LBP / BPI / CETP family, N-terminal domain containing protein 0.0041 0.008 0.011
Schistosoma mansoni hypothetical protein 0.0046 0.0095 0.0154
Trypanosoma brucei alpha tubulin 0.0264 0.0767 0.2842
Mycobacterium ulcerans monoamine oxidase 0.0083 0.0211 0.0588
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0192 0.0546 0.0887
Loa Loa (eye worm) hypothetical protein 0.0023 0.0027 0.0206
Leishmania major importin beta-1 subunit, putative 0.0024 0.003 0.011
Plasmodium vivax tubulin beta chain, putative 0.0142 0.0392 0.1453
Echinococcus granulosus sterol regulatory element binding protein 0.0047 0.01 0.0163
Trichomonas vaginalis tubulin beta chain, putative 0.0264 0.0767 1
Echinococcus multilocularis tubulin epsilon chain 0.0142 0.0392 0.0506
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0083 0.0211 0.0342
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0034 0.0058 0.0216
Onchocerca volvulus 0.0041 0.008 0.008
Schistosoma mansoni tyrosinase precursor 0.0272 0.0791 0.1284
Schistosoma mansoni hypothetical protein 0.004 0.0079 0.0128
Echinococcus multilocularis tubulin alpha 3 chain 0.0264 0.0767 0.0991
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0203 0.0577 0.7527
Schistosoma mansoni tubulin subunit alpha 0.0062 0.0145 0.0235
Echinococcus granulosus cpg binding protein 0.006 0.014 0.0227
Schistosoma mansoni microtubule-associated protein tau 0.202 0.6157 1
Brugia malayi Tubulin alpha chain 0.0264 0.0767 0.1057
Loa Loa (eye worm) latrophilin receptor protein 2 0.0065 0.0156 0.1204
Echinococcus multilocularis muscleblind protein 0.0437 0.1298 0.1676
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0305 0.0892 0.3304
Trichomonas vaginalis tubulin beta chain, putative 0.0264 0.0767 1
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0036 0.0132
Brugia malayi Niemann-Pick C1 protein precursor 0.011 0.0293 0.0404
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0008 0.011
Leishmania major 4-coumarate:coa ligase-like protein 0.005 0.0108 0.04
Plasmodium falciparum protoporphyrinogen oxidase 0.0083 0.0211 0.0781
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0034 0.0058 0.0216
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0023 0.003
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0023 0.0085
Leishmania major beta tubulin 0.0142 0.0392 0.1453
Schistosoma mansoni tubulin subunit alpha 0.0264 0.0767 0.1246
Brugia malayi Tubulin beta-1 chain 0.0142 0.0392 0.054
Schistosoma mansoni tubulin subunit beta 0.0142 0.0392 0.0637
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0034 0.0058 0.0075
Echinococcus granulosus Protein patched homolog 1 0.0047 0.01 0.0163
Loa Loa (eye worm) hypothetical protein 0.0083 0.0211 0.1624
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0142 0.0392 0.1453
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0036 0.0278
Echinococcus multilocularis importin subunit beta 1 0.003 0.0047 0.0061
Mycobacterium ulcerans oxidoreductase 0.0083 0.0211 0.0588
Mycobacterium tuberculosis Conserved hypothetical protein 0.0161 0.0449 0.1347
Echinococcus multilocularis tubulin beta 1 chain 0.0142 0.0392 0.0506
Echinococcus multilocularis transient receptor potential ion channel A 0.0097 0.0254 0.0328
Schistosoma mansoni hypothetical protein 0.0811 0.2445 0.3971
Loa Loa (eye worm) hepatopoietin HPO2 0.0034 0.0058 0.0449
Loa Loa (eye worm) LBP/BPI/CETP family domain-containing protein 0.0023 0.0027 0.0206
Echinococcus granulosus tubulin alpha 0.0142 0.0392 0.0637
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.003 0.011
Echinococcus granulosus Tubulin beta 2C chain 0.0142 0.0392 0.0637
Loa Loa (eye worm) hypothetical protein 0.003 0.0047 0.0363
Brugia malayi LBP / BPI / CETP family, C-terminal domain containing protein 0.0023 0.0027 0.0037
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0192 0.0546 0.0753
Schistosoma mansoni intermediate filament proteins 0.0026 0.0036 0.0058
Loa Loa (eye worm) RNA binding protein 0.0071 0.0174 0.1342
Trichomonas vaginalis tubulin epsilon chain, putative 0.0264 0.0767 1
Leishmania major 4-coumarate:coa ligase-like protein 0.005 0.0108 0.04
Schistosoma mansoni amine oxidase 0.0083 0.0211 0.0342
Onchocerca volvulus 0.0041 0.008 0.008
Trypanosoma cruzi zeta tubulin, putative 0.0062 0.0145 0.0537
Schistosoma mansoni patched 1 0.0047 0.01 0.0163
Echinococcus multilocularis protein dispatched 1 0.0054 0.0121 0.0156
Echinococcus multilocularis transient receptor potential gamma protein 0.0101 0.0265 0.0342
Onchocerca volvulus 0.0041 0.008 0.008
Echinococcus multilocularis sterol regulatory element binding protein 0.0047 0.01 0.0129
Brugia malayi intermediate filament protein 0.0026 0.0036 0.005
Echinococcus multilocularis tar DNA binding protein 0.0071 0.0174 0.0225
Schistosoma mansoni transient receptor potential channel 4 0.0101 0.0265 0.043
Brugia malayi LBP / BPI / CETP family, C-terminal domain containing protein 0.0023 0.0027 0.0037
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0036 0.0132
Onchocerca volvulus 0.0083 0.0211 0.0211
Schistosoma mansoni hypothetical protein 0.0141 0.039 0.0633
Trypanosoma brucei zeta tubulin, putative 0.0062 0.0145 0.0537
Brugia malayi hypothetical protein 0.0026 0.0036 0.0049
Echinococcus multilocularis protoporphyrinogen oxidase 0.0083 0.0211 0.0272
Loa Loa (eye worm) hypothetical protein 0.0026 0.0036 0.0274
Echinococcus multilocularis tubulin gamma 1 chain 0.0142 0.0392 0.0506
Plasmodium vivax tubulin gamma chain, putative 0.0142 0.0392 0.1453
Echinococcus granulosus transient receptor potential gamma protein 0.0101 0.0265 0.043
Trichomonas vaginalis tubulin beta chain, putative 0.0142 0.0392 0.5112
Loa Loa (eye worm) hypothetical protein 0.005 0.0108 0.0831
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0071 0.0174 0.1342
Trichomonas vaginalis tubulin alpha chain, putative 0.0142 0.0392 0.5112
Brugia malayi Tubulin beta chain 0.0062 0.0145 0.02
Echinococcus granulosus beta tubulin 0.0142 0.0392 0.0637
Echinococcus multilocularis lamin 0.0026 0.0036 0.0047
Plasmodium vivax tubulin alpha chain, putative 0.0264 0.0767 0.2842
Echinococcus multilocularis protein patched 0.0047 0.01 0.0129
Brugia malayi Tubulin gamma chain 0.0142 0.0392 0.054
Schistosoma mansoni tyrosinase precursor 0.0272 0.0791 0.1284
Echinococcus multilocularis Tubulin beta 2C chain 0.0142 0.0392 0.0506
Trypanosoma brucei tubulin delta chain 0.0062 0.0145 0.0537
Onchocerca volvulus Huntingtin homolog 0.012 0.0323 0.0323
Brugia malayi hypothetical protein 0.0023 0.0027 0.0037
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0083 0.0211 0.0588
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0145 0.1889
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0063 0.0189
Echinococcus granulosus lysine specific histone demethylase 1A 0.0083 0.0211 0.0342
Schistosoma mansoni lamin 0.0026 0.0036 0.0058
Giardia lamblia Delta tubulin 0.0062 0.0145 0.0456
Loa Loa (eye worm) tubulin alpha 2 0.0203 0.0577 0.4449
Brugia malayi F/Y-rich N-terminus family protein 0.0017 0.0009 0.0012
Schistosoma mansoni amine oxidase 0.0083 0.0211 0.0342
Leishmania major GTP-binding protein, putative 0.0022 0.0023 0.0085
Onchocerca volvulus 0.0057 0.013 0.013
Plasmodium falciparum beta-ketoacyl-ACP synthase III 0.0308 0.0899 0.3332
Entamoeba histolytica fatty acid elongase, putative 0.004 0.0078 0.1014
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0079 0.0128
Onchocerca volvulus 0.0023 0.0027 0.0027
Echinococcus multilocularis Tubulin alpha 1 chain 0.0264 0.0767 0.0991
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0063 0.0189
Schistosoma mansoni transient receptor potential channel 0.0067 0.016 0.026
Loa Loa (eye worm) hypothetical protein 0.0065 0.0156 0.1204
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0036 0.0132
Echinococcus multilocularis hypothetical protein 0.0264 0.0767 0.0991
Mycobacterium leprae cell division protein FtsZ 0.0062 0.0145 0.6874
Plasmodium falciparum importin beta, putative 0.003 0.0047 0.0175
Trichomonas vaginalis tubulin alpha chain, putative 0.0081 0.0202 0.2639
Loa Loa (eye worm) hypothetical protein 0.0026 0.0036 0.0278
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0083 0.0211 0.0781
Trichomonas vaginalis tubulin alpha chain, putative 0.0081 0.0202 0.2639
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0023 0.0037
Leishmania major mitochondrial DNA polymerase beta 0.0305 0.0892 0.3304
Echinococcus granulosus lamin 0.0026 0.0036 0.0058
Echinococcus granulosus tubulin alpha 1C chain 0.0264 0.0767 0.1246
Loa Loa (eye worm) CXXC zinc finger family protein 0.0057 0.013 0.1002
Plasmodium falciparum alpha tubulin 2 0.0264 0.0767 0.2842
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0894 0.2699 1
Leishmania major beta tubulin 0.0142 0.0392 0.1453
Echinococcus granulosus tubulin alpha chain 0.0264 0.0767 0.1246
Trypanosoma cruzi epsilon tubulin, putative 0.0142 0.0392 0.1453
Leishmania major beta tubulin 0.0142 0.0392 0.1453
Trypanosoma cruzi UDP-galactopyranose mutase 0.0083 0.0211 0.0781
Echinococcus granulosus neuropeptide receptor A26 0.0451 0.1341 0.2178
Chlamydia trachomatis protoporphyrinogen oxidase 0.0083 0.0211 0.1705
Entamoeba histolytica acyl-CoA synthetase, putative 0.005 0.0108 0.1406
Brugia malayi RNA, U transporter 1 0.0085 0.0217 0.0299
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0108 0.0301
Echinococcus granulosus tubulin alpha 3 chain 0.0264 0.0767 0.1246
Echinococcus multilocularis Tubulin beta 2C chain 0.0142 0.0392 0.0506
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0108 0.0301
Echinococcus granulosus peroxisome assembly protein 26 0.0264 0.0767 0.1246
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0192 0.0546 0.0887
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0034 0.0058 0.0216
Schistosoma mansoni hypothetical protein 0.0171 0.0481 0.0781
Loa Loa (eye worm) hypothetical protein 0.0203 0.0577 0.4449
Loa Loa (eye worm) hypothetical protein 0.0083 0.0211 0.1624
Echinococcus multilocularis tubulin delta chain 0.0062 0.0145 0.0187
Entamoeba histolytica tubulin family protein 0.0142 0.0392 0.5112
Toxoplasma gondii beta-tubulin, putative 0.0142 0.0392 0.1453
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0087 0.0322
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0174 0.0283
Brugia malayi Tubulin alpha chain 0.0062 0.0145 0.02
Loa Loa (eye worm) hypothetical protein 0.0037 0.0069 0.0534
Giardia lamblia Beta tubulin 0.0142 0.0392 0.138
Leishmania major epsilon tubulin, putative 0.0142 0.0392 0.1453
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0043 0.0087 0.0322
Toxoplasma gondii histone lysine-specific demethylase 0.0083 0.0211 0.0781
Brugia malayi Muscleblind-like protein 0.0437 0.1298 0.1788
Leishmania major alpha tubulin 0.0264 0.0767 0.2842
Entamoeba histolytica hypothetical protein 0.004 0.0079 0.1026
Loa Loa (eye worm) hypothetical protein 0.0023 0.0027 0.0206
Echinococcus granulosus dnaJ subfamily B 0.0811 0.2445 0.3971
Echinococcus granulosus tubulin alpha 3 chain 0.0264 0.0767 0.1246
Echinococcus multilocularis lamin dm0 0.0026 0.0036 0.0047
Echinococcus multilocularis tubulin subunit TubB 0.0264 0.0767 0.0991
Trichomonas vaginalis tubulin alpha chain, putative 0.0142 0.0392 0.5112
Trypanosoma cruzi UDP-galactopyranose mutase 0.0083 0.0211 0.0781
Leishmania major beta tubulin 0.0142 0.0392 0.1453
Brugia malayi Calcitonin receptor-like protein seb-1 0.0207 0.0591 0.0814
Loa Loa (eye worm) hypothetical protein 0.0063 0.015 0.1152
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0043 0.0087 0.0322
Mycobacterium ulcerans hypothetical protein 0.0161 0.0449 0.1251
Trypanosoma cruzi zeta tubulin, putative 0.0062 0.0145 0.0537
Trypanosoma brucei beta tubulin 0.0142 0.0392 0.1453
Schistosoma mansoni importin beta-1 0.003 0.0047 0.0077
Entamoeba histolytica fatty acid elongase, putative 0.004 0.0078 0.1014
Mycobacterium tuberculosis Conserved hypothetical protein 0.0083 0.0211 0.0633
Brugia malayi Telomerase reverse transcriptase 0.2378 0.7256 1
Loa Loa (eye worm) hypothetical protein 0.012 0.0323 0.2492
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.003 0.0388
Leishmania major beta tubulin 0.0142 0.0392 0.1453
Loa Loa (eye worm) LBP/BPI/CETP family domain-containing protein 0.0023 0.0027 0.0206
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.2536 0.7743 1
Brugia malayi CXXC zinc finger family protein 0.0057 0.013 0.0179
Giardia lamblia Alpha-tubulin 0.0264 0.0767 0.2781
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0079 0.0128
Brugia malayi hypothetical protein 0.0023 0.0027 0.0037
Brugia malayi CHE-14 protein 0.0047 0.01 0.0138
Leishmania major telomerase reverse transcriptase, putative 0.0894 0.2699 1
Echinococcus multilocularis snurportin 1 0.032 0.0937 0.121
Trichomonas vaginalis tubulin, putative 0.0062 0.0145 0.1889
Leishmania major beta tubulin 0.0142 0.0392 0.1453
Leishmania major alpha tubulin 0.0264 0.0767 0.2842
Leishmania major alpha tubulin 0.0264 0.0767 0.2842
Trichomonas vaginalis tubulin gamma chain, putative 0.0142 0.0392 0.5112
Brugia malayi TAR-binding protein 0.0071 0.0174 0.024
Loa Loa (eye worm) tubulin beta chain 0.0142 0.0392 0.3022
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0036 0.0132
Echinococcus granulosus tubulin beta 1 chain 0.0142 0.0392 0.0637
Leishmania major beta tubulin 0.0142 0.0392 0.1453
Toxoplasma gondii alpha tubulin TUBA1 0.0264 0.0767 0.2842
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0192 0.0546 0.4208
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0018 0.0009 0.0015
Brugia malayi tubulin alpha chain - mouse 0.0264 0.0767 0.1057
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0264 0.0767 1
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0305 0.0892 0.3304
Loa Loa (eye worm) alpha-tubulin 0.0264 0.0767 0.5911
Brugia malayi Tubulin alpha-2 chain 0.0264 0.0767 0.1057
Echinococcus granulosus beta tubulin 0.0142 0.0392 0.0637
Mycobacterium ulcerans beta-ketoacyl synthase-like protein 0.0308 0.0899 0.2509
Toxoplasma gondii beta tubulin 0.0142 0.0392 0.1453
Brugia malayi SWIRM domain containing protein 0.0083 0.0211 0.0291
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0112 0.0298 0.0485
Schistosoma mansoni tubulin subunit alpha 0.0264 0.0767 0.1246
Entamoeba histolytica fatty acid elongase, putative 0.004 0.0078 0.1014
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0047 0.0175
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0034 0.0058 0.0216
Leishmania major beta tubulin 0.0142 0.0392 0.1453
Onchocerca volvulus 0.0081 0.0202 0.0202
Trichomonas vaginalis tubulin gamma chain, putative 0.0142 0.0392 0.5112
Trypanosoma cruzi beta tubulin, putative 0.0142 0.0392 0.1453
Echinococcus granulosus tubulin alpha chain 0.0264 0.0767 0.1246
Schistosoma mansoni hypothetical protein 0.0065 0.0156 0.0254
Onchocerca volvulus 0.0026 0.0036 0.0036
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0047 0.01 0.0772
Loa Loa (eye worm) histone methyltransferase 0.0018 0.0009 0.0071
Echinococcus granulosus lysine specific histone demethylase 1A 0.0083 0.0211 0.0342
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0036 0.0132
Schistosoma mansoni cpg binding protein 0.0057 0.013 0.0211
Loa Loa (eye worm) hypothetical protein 0.0017 0.0008 0.0065
Loa Loa (eye worm) hypothetical protein 0.0207 0.0591 0.4551
Loa Loa (eye worm) hypothetical protein 0.0437 0.1298 1
Mycobacterium tuberculosis Cell division protein FtsZ 0.0062 0.0145 0.0435
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0047 0.0175
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.1182 0.3585 1
Trichomonas vaginalis tubulin beta chain, putative 0.0081 0.0202 0.2639
Loa Loa (eye worm) hypothetical protein 0.012 0.0323 0.2492
Trypanosoma brucei alpha tubulin 0.0264 0.0767 0.2842
Schistosoma mansoni hypothetical protein 0.0065 0.0156 0.0254
Plasmodium vivax hypothetical protein, conserved 0.0083 0.0211 0.0781
Entamoeba histolytica Ran family GTPase 0.0022 0.0023 0.0298
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0023 0.0085
Schistosoma mansoni ran 0.0022 0.0023 0.0037
Loa Loa (eye worm) TAR-binding protein 0.0071 0.0174 0.1342
Trichomonas vaginalis tubulin epsilon chain, putative 0.0142 0.0392 0.5112
Trypanosoma brucei epsilon tubulin 0.0142 0.0392 0.1453
Onchocerca volvulus 0.0041 0.008 0.008
Entamoeba histolytica tubulin alpha-1 chain 0.0264 0.0767 1
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0174 0.0283
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.005 0.0108 0.0301
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0272 0.0791 0.109
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0065 0.0156 0.0215
Leishmania major beta tubulin 0.0142 0.0392 0.1453
Loa Loa (eye worm) hypothetical protein 0.0023 0.0027 0.0206
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0192 0.0546 0.0705
Brugia malayi amine oxidase, flavin-containing family protein 0.0083 0.0211 0.0291
Echinococcus granulosus expressed conserved protein 0.0103 0.0273 0.0443
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.003 0.0388
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.1099 0.3329 1
Trypanosoma brucei zeta tubulin 0.0062 0.0145 0.0537
Toxoplasma gondii Erv1 / Alr family protein 0.0034 0.0058 0.0216
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0144 0.0398 0.1476
Echinococcus multilocularis beta tubulin 0.0142 0.0392 0.0506
Echinococcus granulosus geminin 0.0171 0.0481 0.0781
Schistosoma mansoni tubulin subunit beta 0.0142 0.0392 0.0637
Brugia malayi hypothetical protein 0.0083 0.0211 0.0291
Leishmania major UDP-galactopyranose mutase 0.0083 0.0211 0.0781
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0023 0.0085
Echinococcus multilocularis Tubulin beta 2C chain 0.0142 0.0392 0.0506
Echinococcus multilocularis Tubulin alpha 1 chain 0.0264 0.0767 0.0991
Echinococcus granulosus short transient receptor potential channel 6 0.0067 0.016 0.026
Echinococcus granulosus Tubulin alpha 1 chain 0.0264 0.0767 0.1246
Schistosoma mansoni ran 0.0022 0.0023 0.0037
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.0311 0.24
Echinococcus multilocularis tubulin alpha chain 0.0264 0.0767 0.0991
Mycobacterium ulcerans dehydrogenase 0.0083 0.0211 0.0588
Leishmania major beta tubulin 0.0142 0.0392 0.1453
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.1182 0.3585 1
Schistosoma mansoni alpha tubulin 0.0264 0.0767 0.1246
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0037 0.007 0.0091
Echinococcus multilocularis tubulin subunit beta 0.0142 0.0392 0.0506
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0308 0.0899 0.2509
Loa Loa (eye worm) hypothetical protein 0.0047 0.01 0.0772
Trypanosoma brucei epsilon tubulin 0.0142 0.0392 0.1453
Mycobacterium tuberculosis Possible oxidoreductase 0.0083 0.0211 0.0633
Schistosoma mansoni lamin 0.0026 0.0036 0.0058
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0121 0.0326 0.0529
Brugia malayi beta-tubulin, identical 0.0142 0.0392 0.054
Schistosoma mansoni hypothetical protein 0.0046 0.0095 0.0154
Leishmania major alpha tubulin 0.0264 0.0767 0.2842
Loa Loa (eye worm) hypothetical protein 0.0041 0.008 0.0616
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0047 0.0175
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0203 0.0577 0.4449
Echinococcus multilocularis tubulin alpha 0.0142 0.0392 0.0506
Echinococcus multilocularis Niemann Pick C1 protein 0.0157 0.0438 0.0566
Trichomonas vaginalis tubulin beta chain, putative 0.0264 0.0767 1
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0174 0.0283
Brugia malayi RNA binding protein 0.0071 0.0174 0.024
Leishmania major gamma-tubulin 0.0142 0.0392 0.1453
Echinococcus multilocularis cpg binding protein 0.006 0.014 0.0181
Entamoeba histolytica hypothetical protein 0.004 0.0079 0.1026
Brugia malayi hypothetical protein 0.012 0.0323 0.0446
Echinococcus granulosus tubulin alpha chain 0.0264 0.0767 0.1246
Loa Loa (eye worm) tubulin beta-4 chain 0.0142 0.0392 0.3022
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0144 0.0398 0.1476
Toxoplasma gondii beta-1 tubulin, putative 0.0142 0.0392 0.1453
Leishmania major hypothetical protein, conserved 0.0034 0.0058 0.0216
Echinococcus multilocularis neuropeptide s receptor 0.0451 0.1341 0.1732
Loa Loa (eye worm) hypothetical protein 0.005 0.0108 0.0831
Loa Loa (eye worm) hypothetical protein 0.0141 0.039 0.3002
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0184 0.052 0.6777

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 40 nM Inhibition of CETP in human plasma assessed as transfer of fluorescently labelled cholesteryl ester to VLDL by fluorimetry ChEMBL. 22543028

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.