Detailed information for compound 168824

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 433.162 | Formula: C17H17Cl4N5--
  • H donors: 2 H acceptors: 1 LogP: 4.7 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: NC(=NN=C1CC(Cc2c1c(C)ccn2)c1c(Cl)cccc1Cl)N.[Cl-].[Cl-]
  • InChi: 1S/C17H17Cl2N5.2ClH/c1-9-5-6-22-13-7-10(16-11(18)3-2-4-12(16)19)8-14(15(9)13)23-24-17(20)21;;/h2-6,10H,7-8H2,1H3,(H4,20,21,24);2*1H/p-2/b23-14+;;
  • InChiKey: UMHYKTSFXPAXJD-PQZUSRQGSA-L  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi hypothetical protein 0.0025 0.0074 0.0196
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0098 0.0536 0.1224
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0112 0.0239
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0066 0.0132
Echinococcus multilocularis ubiquitin specific protease 41 0.0037 0.0153 0.0144
Schistosoma mansoni hypothetical protein 0.0042 0.0184 0.0407
Loa Loa (eye worm) hypothetical protein 0.0054 0.0256 0.0749
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.1729 0.5325
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0031 0.0112 0.0311
Echinococcus granulosus lamin dm0 0.0055 0.0265 0.0594
Echinococcus granulosus expressed conserved protein 0.0096 0.0523 0.1194
Brugia malayi Latrophilin receptor protein 2 0.0098 0.0536 0.1596
Trichomonas vaginalis glucosylceramidase, putative 0.0364 0.2214 0.6826
Echinococcus multilocularis adhesion regulating molecule 1 0.0538 0.331 0.3304
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0062 0.0311 0.0701
Echinococcus granulosus SAM and MBT domain containing protein 0.0049 0.0228 0.0509
Trichomonas vaginalis glucosylceramidase, putative 0.0346 0.2096 0.6462
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0123 0.035
Trichomonas vaginalis glucosylceramidase, putative 0.0346 0.2096 0.6462
Loa Loa (eye worm) hypothetical protein 0.0031 0.0112 0.0311
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0248 0.0554
Onchocerca volvulus 0.0049 0.0228 0.105
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0037 0.0833
Entamoeba histolytica hypothetical protein 0.0037 0.0153 0.0685
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0031 0.0112 0.0103
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0038 0.0154 0.0145
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0194 0.1142 0.1134
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0032 0.0122 0.0113
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0194 0.057
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0037 0.0083
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0026 0.0083 0.187
Plasmodium vivax 26S proteasome regulatory subunit RPN13, putative 0.0084 0.0446 1
Trichomonas vaginalis conserved hypothetical protein 0.0174 0.1016 0.3116
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0248 0.0554
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.002 0.0033
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0026 0.0083 0.1677
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0194 0.057
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0018 0.0032 0.0728
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.1729 0.5325
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.003 0.0104 0.0286
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0287 0.1729 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0037 0.0616
Echinococcus granulosus sterol regulatory element binding protein 0.0044 0.0194 0.043
Trichomonas vaginalis glucosylceramidase, putative 0.0527 0.3238 1
Echinococcus granulosus GPCR family 2 0.0098 0.0536 0.1224
Brugia malayi MH2 domain containing protein 0.0237 0.1413 0.4253
Schistosoma mansoni smad1 5 8 and 0.0016 0.0019 0.0024
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0248 0.0239
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0123 0.035
Echinococcus granulosus histone lysine methyltransferase setb 0.0018 0.003 0.0048
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0031 0.0112 0.0103
Echinococcus granulosus Smad4 0.0016 0.0019 0.0024
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0031 0.0113 0.012
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0031 0.0112 0.0311
Loa Loa (eye worm) hypothetical protein 0.0031 0.0112 0.0311
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0048 0.1085
Giardia lamblia GTOR 0.0044 0.0194 0.0929
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0037 0.0028
Brugia malayi hypothetical protein 0.0037 0.0153 0.0436
Loa Loa (eye worm) hypothetical protein 0.0018 0.003 0.0063
Onchocerca volvulus Proteasomal ubiquitin receptor ADRM1 homolog 0.0342 0.2071 0.988
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0049 0.0228 0.105
Loa Loa (eye worm) hypothetical protein 0.0026 0.0079 0.0211
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0153 0.3432
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.0053 0.0134
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0153 0.0144
Brugia malayi steroid hormone receptor 0.0031 0.0112 0.0311
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0122 0.0113
Brugia malayi Bromodomain containing protein 0.004 0.017 0.0487
Leishmania major DNA polymerase kappa, putative 0.0019 0.0037 0.016
Brugia malayi ImpB/MucB/SamB family protein 0.0044 0.0195 0.0563
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0228 0.0509
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0037 0.0059
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0037 0.0065
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0112 0.0311
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0067 0.0175
Echinococcus multilocularis Smad4 0.0016 0.0019 0.001
Echinococcus multilocularis thyroid hormone receptor alpha 0.0031 0.0112 0.0103
Loa Loa (eye worm) isocitrate dehydrogenase 0.0032 0.0122 0.0341
Brugia malayi Niemann-Pick C1 protein precursor 0.0102 0.0562 0.1675
Echinococcus multilocularis expressed conserved protein 0.0096 0.0523 0.0514
Trypanosoma cruzi ISWI complex protein 0.0016 0.0018 0.0184
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0052 0.0248 0.0722
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0044 0.0194 0.1099
Loa Loa (eye worm) hypothetical protein 0.0098 0.0532 0.1585
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0067 0.0175
Loa Loa (eye worm) hypothetical protein 0.0031 0.0112 0.0311
Trypanosoma cruzi DNA polymerase eta, putative 0.0031 0.0113 0.2347
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0019 0.001
Loa Loa (eye worm) hypothetical protein 0.0031 0.0112 0.0311
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.003 0.0048
Loa Loa (eye worm) steroid hormone receptor 0.0031 0.0112 0.0311
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0037 0.0833
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0037 0.0833
Brugia malayi nuclear receptor RXR 0.0016 0.002 0.0033
Loa Loa (eye worm) intermediate filament protein 0.0055 0.0265 0.0775
Schistosoma mansoni hypothetical protein 0.03 0.1806 0.4176
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0016 0.002 0.0033
Trichomonas vaginalis glucosylceramidase, putative 0.0346 0.2096 0.6462
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0031 0.0112 0.0103
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0019 0.0024
Brugia malayi Bromodomain containing protein 0.0078 0.0412 0.122
Loa Loa (eye worm) hypothetical protein 0.0026 0.0079 0.0211
Brugia malayi N-terminal motif family protein 0.0179 0.1049 0.3151
Trypanosoma cruzi target of rapamycin kinase 3 0.0035 0.0138 0.2928
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0037 0.0833
Schistosoma mansoni coup transcription factor 0.0031 0.0112 0.0239
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0112 0.0311
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0037 0.0833
Loa Loa (eye worm) hypothetical protein 0.0056 0.0271 0.0794
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0098 0.0536 0.0527
Loa Loa (eye worm) hypothetical protein 0.0179 0.1047 0.3145
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0123 0.035
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.014 0.0803 0.5
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0056 0.0271 0.0794
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0044 0.0194 0.4356
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0037 0.0153 0.0334
Brugia malayi Steroid receptor seven-up type 2 0.0031 0.0112 0.0311
Brugia malayi Cytochrome P450 family protein 0.0046 0.0207 0.06
Echinococcus granulosus adhesion regulating molecule 1 0.0538 0.331 0.767
Brugia malayi Calcitonin receptor-like protein seb-1 0.031 0.1872 0.5643
Brugia malayi PHD-finger family protein 0.0026 0.0082 0.022
Schistosoma mansoni hypothetical protein 0.0042 0.0184 0.0407
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0083 0.0225
Schistosoma mansoni zinc finger protein 0.0016 0.0018 0.0021
Schistosoma mansoni hypothetical protein 0.0098 0.0536 0.1224
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0019 0.0031
Loa Loa (eye worm) hypothetical protein 0.0016 0.002 0.0033
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.002 0.0026
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0031 0.0112 0.0239
Echinococcus multilocularis protein patched 0.0044 0.0194 0.0185
Leishmania major ubiquitin-conjugating enzyme e2, putative 0.004 0.0167 0.0938
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0031 0.0112 0.0311
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0123 0.035
Echinococcus granulosus ubiquitin conjugating enzyme E2 N 0.004 0.0167 0.0367
Brugia malayi MH1 domain containing protein 0.0016 0.0019 0.0031
Echinococcus multilocularis lamin 0.0055 0.0265 0.0256
Loa Loa (eye worm) hypothetical protein 0.0102 0.0562 0.1675
Trypanosoma brucei proteasome complex subunit Rpn13 ubiquitin receptor, putative 0.0084 0.0446 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0031 0.0112 0.0239
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0112 0.0103
Brugia malayi Smad1 0.0016 0.0019 0.0031
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0015 0.001 0.0001
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0031 0.0112 0.0311
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0032 0.0122 0.0299
Echinococcus multilocularis zinc finger protein 0.002 0.0047 0.0037
Trypanosoma cruzi cytochrome P450, putative 0.0018 0.0033 0.0512
Loa Loa (eye worm) latrophilin receptor protein 2 0.0098 0.0536 0.1596
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0122 0.0666
Entamoeba histolytica hypothetical protein 0.0037 0.0153 0.0685
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0037 0.0059
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0031 0.0112 0.0239
Plasmodium falciparum 26S proteasome regulatory subunit RPN13, putative 0.028 0.1685 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0031 0.0112 0.0239
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0083 0.0225
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.004 0.0167 0.0479
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0032 0.0122 0.2561
Schistosoma mansoni Smad4 0.0016 0.0019 0.0024
Echinococcus granulosus dna polymerase kappa 0.0019 0.0037 0.0065
Brugia malayi CHE-14 protein 0.0044 0.0194 0.056
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0037 0.0616
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0037 0.0833
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0015 0.001 0.0231
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0037 0.0085
Schistosoma mansoni smad1 5 8 and 0.0016 0.0019 0.0024
Echinococcus multilocularis flap endonuclease 1 0.0026 0.0083 0.0074
Trichomonas vaginalis glucosylceramidase, putative 0.0364 0.2214 0.6826
Toxoplasma gondii adhesion regulating molecule region protein, putative 0.0538 0.331 1
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0034 0.0075
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0031 0.0112 0.0311
Echinococcus multilocularis Niemann Pick C1 protein 0.0102 0.0562 0.0554
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0044 0.0194 0.4223
Schistosoma mansoni smad 0.0016 0.0019 0.0024
Trichomonas vaginalis glucosylceramidase, putative 0.0346 0.2096 0.6462
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0112 0.0311
Brugia malayi cytoplasmic intermediate filament protein 0.003 0.0104 0.0286
Echinococcus multilocularis Niemann Pick C1 protein 0.0146 0.0839 0.083
Brugia malayi ecdysteroid receptor 0.0031 0.0112 0.0311
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0031 0.0112 0.0239
Onchocerca volvulus Bile acid receptor homolog 0.0031 0.0112 0.0492
Trypanosoma brucei proteasome complex subunit Rpn13 ubiquitin receptor, putative 0.0084 0.0446 1
Echinococcus multilocularis ubiquitin conjugating enzyme E2 N 0.004 0.0167 0.0158
Loa Loa (eye worm) hypothetical protein 0.0031 0.0112 0.0311
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0074 0.1654
Loa Loa (eye worm) hypothetical protein 0.0212 0.1253 0.3769
Loa Loa (eye worm) phosphatidylinositol 3 0.0044 0.0194 0.0561
Schistosoma mansoni RAR-like nuclear receptor 0.0031 0.0112 0.0239
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0037 0.0616
Toxoplasma gondii ubiquitin-conjugating enzyme subfamily protein 0.004 0.0167 0.0289
Echinococcus granulosus ecdysone induced protein 78C 0.0031 0.0112 0.0239
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0194 0.057
Trypanosoma cruzi proteasome complex subunit Rpn13 ubiquitin receptor, putative 0.0084 0.0446 1
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.003 0.0021
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0153 0.0334
Echinococcus multilocularis histone acetyltransferase MYST2 0.0056 0.0271 0.0262
Trypanosoma brucei ISWI complex protein 0.0016 0.0018 0.0411
Brugia malayi nuclear receptor NHR-88 0.0031 0.0112 0.0311
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0153 0.0442
Loa Loa (eye worm) transcription factor SMAD2 0.0237 0.1413 0.4253
Leishmania major hypothetical protein, conserved 0.028 0.1685 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0122 0.0113
Schistosoma mansoni intermediate filament proteins 0.0055 0.0265 0.0594
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0015 0.001 0.0231
Brugia malayi MH2 domain containing protein 0.0016 0.0019 0.0031
Echinococcus multilocularis geminin 0.0364 0.2215 0.2208
Trypanosoma cruzi DNA polymerase eta, putative 0.0044 0.0195 0.424
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0527 0.3238 0.9783
Schistosoma mansoni hypothetical protein 0.0098 0.0536 0.1224
Entamoeba histolytica hypothetical protein 0.0037 0.0153 0.0685
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0026 0.0083 0.0436
Loa Loa (eye worm) hypothetical protein 0.0037 0.0153 0.0436
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0153 0.0144
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0056 0.0271 0.0262
Echinococcus granulosus polycomb protein SCMH1 0.0049 0.0228 0.0509
Trypanosoma cruzi ISWI complex protein 0.0016 0.0018 0.0184
Echinococcus granulosus zinc finger protein 0.002 0.0047 0.0087
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0032 0.0122 0.1294
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0031 0.0112 0.0311
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0067 0.0175
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0031 0.0112 0.0103
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0031 0.0112 0.0239
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0015 0.001 0.0003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0194 0.057
Echinococcus multilocularis GPCR, family 2 0.0098 0.0536 0.0527
Echinococcus multilocularis protein dispatched 1 0.005 0.0233 0.0224
Loa Loa (eye worm) MBCTL1 0.0056 0.0271 0.0794
Loa Loa (eye worm) cytochrome P450 family protein 0.0046 0.0207 0.06
Trypanosoma brucei unspecified product 0.0019 0.0037 0.0833
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0037 0.0083
Loa Loa (eye worm) cytochrome P450 family protein 0.0018 0.0033 0.0071
Echinococcus granulosus tumor protein p63 0.0666 0.4119 0.9549
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0044 0.0194 0.043
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0049 0.0228 0.0509
Brugia malayi Nuclear hormone receptor-like 1 0.0031 0.0112 0.0311
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.1729 0.5325
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0055 0.0265 0.0775
Loa Loa (eye worm) hypothetical protein 0.0049 0.0228 0.0664
Trichomonas vaginalis glucosylceramidase, putative 0.0346 0.2096 0.6462
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0122 0.0149
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.004 0.0167 0.0486
Schistosoma mansoni hypothetical protein 0.0098 0.0536 0.1224
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.003 0.0048
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0044 0.0194 0.4356
Loa Loa (eye worm) mbt repeat family protein 0.0049 0.0228 0.0664
Loa Loa (eye worm) hypothetical protein 0.0016 0.002 0.0033
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0044 0.0194 0.0561
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0032 0.0122 0.1107
Loa Loa (eye worm) hypothetical protein 0.0031 0.0112 0.0311
Schistosoma mansoni hypothetical protein 0.0037 0.0153 0.0334
Echinococcus granulosus microtubule associated protein 2 0.0697 0.4313 1
Brugia malayi Ubiquitin conjugating enzyme protein 13 0.004 0.0167 0.0479
Schistosoma mansoni steroid hormone receptor ad4bp 0.0031 0.0112 0.0239
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0037 0.0153 0.0436
Plasmodium vivax ubiquitin-conjugating enzyme E2 N, putative 0.004 0.0167 0.2514
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0122 0.2733
Leishmania major cytochrome p450-like protein 0.0018 0.0033 0.0133
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0037 0.0833
Brugia malayi Cytochrome P450 family protein 0.0018 0.0033 0.0071
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0122 0.0149
Brugia malayi Cytochrome P450 family protein 0.0018 0.0033 0.0071
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0098 0.0536 0.1596
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0037 0.0028
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0097 0.0269
Giardia lamblia Flap structure-specific endonuclease 0.0026 0.0083 0.0273
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.1729 0.5325
Loa Loa (eye worm) hypothetical protein 0.0016 0.002 0.0033
Echinococcus granulosus geminin 0.0364 0.2215 0.5126
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0032 0.0122 0.0262
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0037 0.0065
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0031 0.0112 0.0311
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0031 0.0112 0.0311
Schistosoma mansoni hypothetical protein 0.0016 0.0018 0.0021
Schistosoma mansoni patched 1 0.0044 0.0194 0.043
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0016 0.002 0.0026
Echinococcus granulosus histone acetyltransferase MYST2 0.0056 0.0271 0.0609
Echinococcus granulosus FTZ F1 alpha 0.0031 0.0112 0.0239
Onchocerca volvulus 0.0055 0.0265 0.1225
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0019 0.001
Brugia malayi mbt repeat family protein 0.0049 0.0228 0.0664
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0044 0.0194 0.0929
Brugia malayi MH2 domain containing protein 0.0016 0.0019 0.0031
Echinococcus multilocularis musashi 0.0055 0.0265 0.0256
Schistosoma mansoni retinoic acid receptor RXR 0.0031 0.0112 0.0239
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.003 0.0048
Echinococcus granulosus Niemann Pick C1 protein 0.0102 0.0562 0.1285
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0016 0.002 0.0026
Loa Loa (eye worm) hypothetical protein 0.0054 0.0259 0.0756
Loa Loa (eye worm) flap endonuclease-1 0.0026 0.0083 0.0225
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0153 0.0334
Trichomonas vaginalis glucosylceramidase, putative 0.0346 0.2096 0.6462
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0112 0.0239
Trypanosoma cruzi proteasome complex subunit Rpn13 ubiquitin receptor, putative 0.0084 0.0446 1
Schistosoma mansoni bromodomain containing protein 0.0066 0.0335 0.0756
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0153 0.3277
Onchocerca volvulus Protein ultraspiracle homolog 0.0031 0.0112 0.0492
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0031 0.0112 0.0239
Schistosoma mansoni adhesion regulating molecule 1 (110 kD cell membrane glycoprotein) 0.0538 0.331 0.767
Echinococcus granulosus smad 0.0016 0.0019 0.0024
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0037 0.0616
Schistosoma mansoni hypothetical protein 0.0042 0.0184 0.0407
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0031 0.0112 0.0239
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0031 0.0112 0.0239
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0026 0.0083 0.003
Onchocerca volvulus 0.0055 0.0265 0.1225
Brugia malayi latrophilin 2 splice variant baaae 0.0212 0.1253 0.3769
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0031 0.0112 0.0311
Loa Loa (eye worm) hypothetical protein 0.0179 0.1049 0.3151
Echinococcus granulosus dna polymerase eta 0.0044 0.0195 0.0432
Echinococcus multilocularis polycomb protein SCMH1 0.0049 0.0228 0.0219
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0067 0.0175
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0035 0.0138 0.3091
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0044 0.0194 0.1099
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0031 0.0112 0.0492
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0138 0.0394
Plasmodium falciparum ubiquitin-conjugating enzyme E2 N, putative 0.004 0.0167 0.0581
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0037 0.016
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0153 0.0144
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0067 0.0175
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0112 0.0239
Trypanosoma brucei DNA polymerase eta, putative 0.0044 0.0195 0.4374
Echinococcus multilocularis tumor protein p63 0.0666 0.4119 0.4113
Schistosoma mansoni hypothetical protein 0.0098 0.0536 0.1224
Brugia malayi nuclear hormone receptor 0.0031 0.0112 0.0311
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0138 0.0394
Giardia lamblia Fructose-bisphosphate aldolase 0.0287 0.1729 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0081 0.022
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0037 0.0833
Loa Loa (eye worm) hypothetical protein 0.031 0.1872 0.5643
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0015 0.001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0043 0.0186 0.0536
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0153 0.0442
Brugia malayi MH1 domain containing protein 0.0016 0.0019 0.0031
Trypanosoma cruzi proteasome complex subunit Rpn13 ubiquitin receptor, putative 0.0084 0.0446 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0052 0.0248 0.0722
Loa Loa (eye worm) hypothetical protein 0.0016 0.002 0.0033
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0123 0.035
Brugia malayi Flap endonuclease-1 0.0026 0.0083 0.0225
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0112 0.0311
Loa Loa (eye worm) hypothetical protein 0.0027 0.0085 0.023
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0031 0.0112 0.0311
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0037 0.0833
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0066 0.0132
Loa Loa (eye worm) hypothetical protein 0.0016 0.002 0.0033
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0037 0.0153 0.0685
Schistosoma mansoni hypothetical protein 0.0364 0.2215 0.5126
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0031 0.0112 0.0311
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0062 0.0311 0.0302
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.004 0.0167 0.3604
Echinococcus granulosus Protein patched homolog 1 0.0044 0.0194 0.043
Trichomonas vaginalis glucosylceramidase, putative 0.0527 0.3238 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0074 0.1456
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0228 0.0509
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.014 0.0803 1
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0032 0.0122 0.0262
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0112 0.0311
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0104 0.0572 0.1308
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0194 0.1142 0.2632
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0044 0.0194 0.043
Brugia malayi Intermediate filament tail domain containing protein 0.0055 0.0265 0.0775
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0248 0.0554
Trypanosoma brucei ubiquitin-protein ligase, putative 0.004 0.0167 0.3752
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0122 0.0113
Entamoeba histolytica ubiquitin-conjugating enzyme family protein 0.004 0.0167 0.0769
Brugia malayi Adhesion regulating molecule conserved region family protein 0.0538 0.331 1
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.004 0.0167 0.0479
Leishmania major DNA polymerase eta, putative 0.0031 0.0113 0.0611
Loa Loa (eye worm) hypothetical protein 0.0074 0.0384 0.1134
Echinococcus granulosus intermediate filament protein 0.0055 0.0265 0.0594
Loa Loa (eye worm) hypothetical protein 0.0538 0.331 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.1729 0.5325
Loa Loa (eye worm) hypothetical protein 0.0044 0.0194 0.056
Schistosoma mansoni nuclear hormone receptor 0.0031 0.0112 0.0239
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0044 0.0194 0.0185
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.1729 0.5325
Brugia malayi intermediate filament protein 0.0055 0.0265 0.0775
Schistosoma mansoni flap endonuclease-1 0.0024 0.0067 0.0135
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.004 0.0167 0.3604
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0138 0.0394
Schistosoma mansoni lamin 0.0055 0.0265 0.0594
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0037 0.0153 0.0334
Leishmania major hypothetical protein, conserved 0.0016 0.0018 0.0048
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0179 0.1047 0.3145
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0122 0.2561
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0019 0.0024
Loa Loa (eye worm) hypothetical protein 0.0045 0.0199 0.0574
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0031 0.0112 0.0239
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0044 0.0194 0.4223
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0037 0.0833
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0248 0.0239
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0038 0.0154 0.0337
Entamoeba histolytica Flap nuclease, putative 0.0026 0.0083 0.0273
Brugia malayi ubiquitin conjugating enzyme protein 13 0.004 0.0167 0.0479
Brugia malayi isocitrate dehydrogenase 0.0032 0.0122 0.0341
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0031 0.0112 0.0311
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0112 0.0311
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0103 0.0288
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.1729 0.5325
Echinococcus multilocularis isocitrate dehydrogenase 0.0032 0.0122 0.0113
Schistosoma mansoni hypothetical protein 0.0212 0.1253 0.2891
Trypanosoma cruzi cytochrome P450, putative 0.0018 0.0033 0.0512
Leishmania major DNA polymerase eta, putative 0.0044 0.0195 0.1103
Entamoeba histolytica hypothetical protein 0.0037 0.0153 0.0685
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0123 0.035
Echinococcus multilocularis lamin dm0 0.0055 0.0265 0.0256
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0138 0.0394
Echinococcus multilocularis sterol regulatory element binding protein 0.0044 0.0194 0.0185
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0123 0.035
Trypanosoma brucei cytochrome P450, putative 0.0018 0.0033 0.0731
Onchocerca volvulus 0.0031 0.0112 0.0492
Loa Loa (eye worm) pigment dispersing factor receptor c 0.031 0.1872 0.5643
Echinococcus granulosus Niemann Pick C1 protein 0.0146 0.0839 0.1928
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0018 0.003 0.0021
Loa Loa (eye worm) hypothetical protein 0.004 0.017 0.0488
Loa Loa (eye worm) Smad1 0.0016 0.0019 0.0031
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0015 0.001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0055 0.0265 0.0775
Brugia malayi hypothetical protein 0.0016 0.002 0.0033
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.1729 0.5325
Plasmodium vivax flap endonuclease 1, putative 0.0026 0.0083 0.0259
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0153 0.3277
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0027 0.0085 0.0076
Loa Loa (eye worm) hypothetical protein 0.0098 0.0536 0.1596
Schistosoma mansoni hypothetical protein 0.0364 0.2215 0.5126
Toxoplasma gondii target of rapamycin (TOR), putative 0.0033 0.0123 0.0153
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.014 0.0803 1
Schistosoma mansoni myelin transcription factor 1 myt1 0.0056 0.0271 0.0609
Echinococcus granulosus lamin 0.0055 0.0265 0.0594
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.003 0.0048
Leishmania major hypothetical protein, conserved 0.0025 0.0074 0.0379
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0044 0.0194 0.056
Trichomonas vaginalis glucosylceramidase, putative 0.0527 0.3238 1
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.004 0.0167 0.0486
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0037 0.0833
Echinococcus multilocularis smad 0.0016 0.0019 0.001
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0098 0.0536 0.1224
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0153 0.0334
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0037 0.0153 0.0852
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0112 0.0239
Loa Loa (eye worm) MH2 domain-containing protein 0.0237 0.1413 0.4253
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0037 0.0833
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0248 0.0554
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0527 0.3238 0.9783
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0037 0.0153 0.0685
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0083 0.0225
Trichomonas vaginalis glucosylceramidase, putative 0.0527 0.3238 1
Schistosoma mansoni microtubule-associated protein tau 0.0697 0.4313 1
Brugia malayi hypothetical protein 0.0016 0.0018 0.0028
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0067 0.0175
Loa Loa (eye worm) hypothetical protein 0.0031 0.0112 0.0311
Brugia malayi photoreceptor-specific nuclear receptor 0.0031 0.0112 0.0311
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0019 0.0024
Trichomonas vaginalis glucosylceramidase, putative 0.0527 0.3238 1
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0037 0.0085
Loa Loa (eye worm) hypothetical protein 0.0044 0.0195 0.0563
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0027 0.0085 0.0177
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0037 0.0065
Trypanosoma cruzi proteasome complex subunit Rpn13 ubiquitin receptor, putative 0.0084 0.0446 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0074 0.0196
Brugia malayi mbt repeat family protein 0.0049 0.0228 0.0664
Echinococcus granulosus flap endonuclease 1 0.0026 0.0083 0.0172
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0031 0.0112 0.0311
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0081 0.022
Schistosoma mansoni DNA polymerase eta 0.0044 0.0195 0.0432
Schistosoma mansoni hypothetical protein 0.0022 0.0053 0.0103
Onchocerca volvulus 0.0098 0.0532 0.2507
Echinococcus multilocularis ecdysone induced protein 78C 0.0031 0.0112 0.0103
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0248 0.0554
Trichomonas vaginalis glucosylceramidase, putative 0.0527 0.3238 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0112 0.0311
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0066 0.0057
Brugia malayi Isocitrate dehydrogenase 0.0032 0.0122 0.0341
Schistosoma mansoni zinc finger protein 0.002 0.0047 0.0087
Treponema pallidum fructose-bisphosphate aldolase 0.0287 0.1729 0.5
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0056 0.0271 0.0609
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0153 0.0442
Echinococcus multilocularis dna polymerase eta 0.0044 0.0195 0.0186
Loa Loa (eye worm) phosphatidylinositol 3 0.0015 0.001 0.0003
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0032 0.0122 0.2733
Echinococcus multilocularis microtubule associated protein 2 0.0697 0.4313 0.4308
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0037 0.0833
Onchocerca volvulus Glucosylceramidase homolog 0.0346 0.2096 1
Schistosoma mansoni lamin 0.0055 0.0265 0.0594
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0102 0.0562 0.3103
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0287 0.1729 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0031 0.0112 0.0239
Schistosoma mansoni hypothetical protein 0.0042 0.0184 0.0407
Trichomonas vaginalis glucosylceramidase, putative 0.0346 0.2096 0.6462
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0067 0.0175
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0179 0.1049 0.4983
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0112 0.0103
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.003 0.0048
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0098 0.0536 0.0527
Loa Loa (eye worm) CYP4Cod1 0.0018 0.0033 0.0071
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.002 0.0033
Echinococcus granulosus ubiquitin specific protease 41 0.0037 0.0153 0.0334
Schistosoma mansoni smad1 5 8 and 0.0016 0.0019 0.0024
Loa Loa (eye worm) cytochrome P450 family protein 0.0018 0.0033 0.0071
Brugia malayi hypothetical protein 0.0016 0.002 0.0033
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0031 0.0112 0.0311
Plasmodium falciparum flap endonuclease 1 0.0026 0.0083 0.006
Echinococcus multilocularis SAM and MBT domain containing protein 0.0049 0.0228 0.0219
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0153 0.0334
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.031 0.1872 0.5643
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0074 0.1456
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0138 0.0394
Schistosoma mansoni ubiquitin conjugating enzyme 13 0.004 0.0167 0.0367
Echinococcus multilocularis FTZ F1 alpha 0.0031 0.0112 0.0103
Trichomonas vaginalis flap endonuclease-1, putative 0.0026 0.0083 0.0226
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0035 0.0138 0.0762
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0044 0.0194 0.0929
Schistosoma mansoni cellular tumor antigen P53 0.0098 0.0532 0.1216
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0019 0.0031
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0016 0.002 0.0011
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0154 0.0444

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = 23 % In vitro inhibition of acid induced swelling in rat platelets by 50% as a measure of NHE inhibition ChEMBL. 12086486

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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