Detailed information for compound 168824

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 433.162 | Formula: C17H17Cl4N5--
  • H donors: 2 H acceptors: 1 LogP: 4.7 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: NC(=NN=C1CC(Cc2c1c(C)ccn2)c1c(Cl)cccc1Cl)N.[Cl-].[Cl-]
  • InChi: 1S/C17H17Cl2N5.2ClH/c1-9-5-6-22-13-7-10(16-11(18)3-2-4-12(16)19)8-14(15(9)13)23-24-17(20)21;;/h2-6,10H,7-8H2,1H3,(H4,20,21,24);2*1H/p-2/b23-14+;;
  • InChiKey: UMHYKTSFXPAXJD-PQZUSRQGSA-L  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii ubiquitin-conjugating enzyme subfamily protein 0.004 0.0167 0.0289
Loa Loa (eye worm) hypothetical protein 0.0538 0.331 1
Loa Loa (eye worm) flap endonuclease-1 0.0026 0.0083 0.0225
Brugia malayi isocitrate dehydrogenase 0.0032 0.0122 0.0341
Trichomonas vaginalis glucosylceramidase, putative 0.0527 0.3238 1
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0019 0.0024
Schistosoma mansoni smad1 5 8 and 0.0016 0.0019 0.0024
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0032 0.0122 0.0113
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0248 0.0239
Loa Loa (eye worm) hypothetical protein 0.0098 0.0536 0.1596
Schistosoma mansoni hypothetical protein 0.0037 0.0153 0.0334
Echinococcus multilocularis musashi 0.0055 0.0265 0.0256
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0074 0.1456
Echinococcus granulosus intermediate filament protein 0.0055 0.0265 0.0594
Schistosoma mansoni RAR-like nuclear receptor 0.0031 0.0112 0.0239
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0112 0.0239
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0037 0.0153 0.0852
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0066 0.0057
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0112 0.0311
Trichomonas vaginalis glucosylceramidase, putative 0.0364 0.2214 0.6826
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0153 0.3277
Trichomonas vaginalis conserved hypothetical protein 0.0174 0.1016 0.3116
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0031 0.0112 0.0239
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0153 0.3432
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0044 0.0194 0.0185
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0112 0.0311
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0194 0.057
Loa Loa (eye worm) cytochrome P450 family protein 0.0046 0.0207 0.06
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0044 0.0194 0.0561
Brugia malayi Calcitonin receptor-like protein seb-1 0.031 0.1872 0.5643
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0062 0.0311 0.0701
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0031 0.0112 0.0311
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0031 0.0112 0.0492
Schistosoma mansoni flap endonuclease-1 0.0024 0.0067 0.0135
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0098 0.0536 0.1224
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0067 0.0175
Echinococcus multilocularis ubiquitin conjugating enzyme E2 N 0.004 0.0167 0.0158
Trichomonas vaginalis glucosylceramidase, putative 0.0527 0.3238 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0031 0.0112 0.0103
Loa Loa (eye worm) hypothetical protein 0.0054 0.0259 0.0756
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0026 0.0083 0.187
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0112 0.0239
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0027 0.0085 0.0076
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0037 0.0028
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0037 0.0833
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0038 0.0154 0.0337
Brugia malayi ubiquitin conjugating enzyme protein 13 0.004 0.0167 0.0479
Echinococcus granulosus flap endonuclease 1 0.0026 0.0083 0.0172
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0031 0.0112 0.0311
Brugia malayi CHE-14 protein 0.0044 0.0194 0.056
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0019 0.0031
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0056 0.0271 0.0262
Leishmania major hypothetical protein, conserved 0.0025 0.0074 0.0379
Echinococcus multilocularis protein patched 0.0044 0.0194 0.0185
Loa Loa (eye worm) phosphatidylinositol 3 0.0044 0.0194 0.0561
Echinococcus multilocularis histone acetyltransferase MYST2 0.0056 0.0271 0.0262
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0066 0.0132
Echinococcus multilocularis protein dispatched 1 0.005 0.0233 0.0224
Schistosoma mansoni bromodomain containing protein 0.0066 0.0335 0.0756
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0037 0.0083
Onchocerca volvulus 0.0055 0.0265 0.1225
Loa Loa (eye worm) hypothetical protein 0.0037 0.0153 0.0436
Plasmodium falciparum ubiquitin-conjugating enzyme E2 N, putative 0.004 0.0167 0.0581
Loa Loa (eye worm) hypothetical protein 0.0027 0.0085 0.023
Echinococcus granulosus ubiquitin conjugating enzyme E2 N 0.004 0.0167 0.0367
Brugia malayi ImpB/MucB/SamB family protein 0.0044 0.0195 0.0563
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0037 0.0833
Loa Loa (eye worm) hypothetical protein 0.0031 0.0112 0.0311
Trichomonas vaginalis glucosylceramidase, putative 0.0346 0.2096 0.6462
Loa Loa (eye worm) hypothetical protein 0.0102 0.0562 0.1675
Brugia malayi MH2 domain containing protein 0.0237 0.1413 0.4253
Entamoeba histolytica hypothetical protein 0.0037 0.0153 0.0685
Loa Loa (eye worm) hypothetical protein 0.0016 0.002 0.0033
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0031 0.0112 0.0103
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.0053 0.0134
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0031 0.0112 0.0311
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0019 0.0024
Entamoeba histolytica hypothetical protein 0.0037 0.0153 0.0685
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0031 0.0112 0.0239
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0037 0.0059
Loa Loa (eye worm) hypothetical protein 0.0031 0.0112 0.0311
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0098 0.0536 0.0527
Loa Loa (eye worm) hypothetical protein 0.0056 0.0271 0.0794
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0031 0.0112 0.0239
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0035 0.0138 0.3091
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0179 0.1049 0.4983
Leishmania major DNA polymerase kappa, putative 0.0019 0.0037 0.016
Echinococcus granulosus microtubule associated protein 2 0.0697 0.4313 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0037 0.0833
Onchocerca volvulus 0.0098 0.0532 0.2507
Schistosoma mansoni hypothetical protein 0.0098 0.0536 0.1224
Brugia malayi Niemann-Pick C1 protein precursor 0.0102 0.0562 0.1675
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0027 0.0085 0.0177
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0123 0.035
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0062 0.0311 0.0302
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0228 0.0509
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0015 0.001 0.0003
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0044 0.0194 0.4223
Loa Loa (eye worm) hypothetical protein 0.0031 0.0112 0.0311
Trypanosoma brucei ISWI complex protein 0.0016 0.0018 0.0411
Schistosoma mansoni retinoic acid receptor RXR 0.0031 0.0112 0.0239
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0138 0.0394
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0122 0.0666
Trypanosoma brucei unspecified product 0.0019 0.0037 0.0833
Trichomonas vaginalis glucosylceramidase, putative 0.0346 0.2096 0.6462
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0037 0.0616
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0018 0.003 0.0021
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0056 0.0271 0.0794
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0287 0.1729 1
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.014 0.0803 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.003 0.0104 0.0286
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0179 0.1047 0.3145
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.1729 0.5325
Leishmania major DNA polymerase eta, putative 0.0031 0.0113 0.0611
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0153 0.0442
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0019 0.0031
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0052 0.0248 0.0722
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0031 0.0112 0.0311
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0153 0.0334
Trypanosoma cruzi cytochrome P450, putative 0.0018 0.0033 0.0512
Onchocerca volvulus Glucosylceramidase homolog 0.0346 0.2096 1
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.004 0.0167 0.0479
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0037 0.0833
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0015 0.001 0.0003
Brugia malayi hypothetical protein 0.0025 0.0074 0.0196
Schistosoma mansoni patched 1 0.0044 0.0194 0.043
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0153 0.0442
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0032 0.0122 0.2561
Echinococcus multilocularis expressed conserved protein 0.0096 0.0523 0.0514
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0032 0.0122 0.0262
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0138 0.0394
Loa Loa (eye worm) intermediate filament protein 0.0055 0.0265 0.0775
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.003 0.0021
Plasmodium vivax 26S proteasome regulatory subunit RPN13, putative 0.0084 0.0446 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0287 0.1729 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0123 0.035
Echinococcus granulosus dna polymerase kappa 0.0019 0.0037 0.0065
Echinococcus multilocularis polycomb protein SCMH1 0.0049 0.0228 0.0219
Brugia malayi MH2 domain containing protein 0.0016 0.0019 0.0031
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0032 0.0122 0.1294
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.1729 0.5325
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0048 0.1085
Onchocerca volvulus Protein ultraspiracle homolog 0.0031 0.0112 0.0492
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0055 0.0265 0.0775
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0037 0.0616
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0097 0.0269
Loa Loa (eye worm) hypothetical protein 0.0016 0.002 0.0033
Trypanosoma cruzi ISWI complex protein 0.0016 0.0018 0.0184
Trypanosoma cruzi ISWI complex protein 0.0016 0.0018 0.0184
Echinococcus multilocularis zinc finger protein 0.002 0.0047 0.0037
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0194 0.1142 0.1134
Plasmodium vivax ubiquitin-conjugating enzyme E2 N, putative 0.004 0.0167 0.2514
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0044 0.0194 0.1099
Echinococcus granulosus zinc finger protein 0.002 0.0047 0.0087
Trichomonas vaginalis glucosylceramidase, putative 0.0527 0.3238 1
Loa Loa (eye worm) hypothetical protein 0.0179 0.1047 0.3145
Schistosoma mansoni cellular tumor antigen P53 0.0098 0.0532 0.1216
Echinococcus multilocularis sterol regulatory element binding protein 0.0044 0.0194 0.0185
Schistosoma mansoni hypothetical protein 0.0042 0.0184 0.0407
Trypanosoma brucei proteasome complex subunit Rpn13 ubiquitin receptor, putative 0.0084 0.0446 1
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0066 0.0132
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0098 0.0536 0.1224
Echinococcus granulosus lamin dm0 0.0055 0.0265 0.0594
Loa Loa (eye worm) latrophilin receptor protein 2 0.0098 0.0536 0.1596
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0122 0.2561
Echinococcus granulosus Smad4 0.0016 0.0019 0.0024
Brugia malayi hypothetical protein 0.0016 0.0018 0.0028
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0112 0.0239
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0038 0.0154 0.0145
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0037 0.0616
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0123 0.035
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0248 0.0554
Brugia malayi Intermediate filament tail domain containing protein 0.0055 0.0265 0.0775
Schistosoma mansoni hypothetical protein 0.0022 0.0053 0.0103
Brugia malayi photoreceptor-specific nuclear receptor 0.0031 0.0112 0.0311
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0031 0.0112 0.0311
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0153 0.0144
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0031 0.0112 0.0103
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0037 0.0153 0.0334
Echinococcus granulosus expressed conserved protein 0.0096 0.0523 0.1194
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0248 0.0554
Loa Loa (eye worm) hypothetical protein 0.0025 0.0074 0.0196
Loa Loa (eye worm) cytochrome P450 family protein 0.0018 0.0033 0.0071
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0248 0.0554
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0037 0.0833
Brugia malayi MH1 domain containing protein 0.0016 0.0019 0.0031
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0122 0.2733
Onchocerca volvulus Bile acid receptor homolog 0.0031 0.0112 0.0492
Loa Loa (eye worm) hypothetical protein 0.0031 0.0112 0.0311
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0248 0.0554
Echinococcus multilocularis dna polymerase eta 0.0044 0.0195 0.0186
Schistosoma mansoni hypothetical protein 0.0042 0.0184 0.0407
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.002 0.0033
Loa Loa (eye worm) hypothetical protein 0.0044 0.0194 0.056
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0037 0.0065
Trypanosoma cruzi target of rapamycin kinase 3 0.0035 0.0138 0.2928
Giardia lamblia Fructose-bisphosphate aldolase 0.0287 0.1729 1
Trypanosoma cruzi proteasome complex subunit Rpn13 ubiquitin receptor, putative 0.0084 0.0446 1
Toxoplasma gondii target of rapamycin (TOR), putative 0.0033 0.0123 0.0153
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0019 0.001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0123 0.035
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0228 0.0509
Echinococcus granulosus ubiquitin specific protease 41 0.0037 0.0153 0.0334
Leishmania major cytochrome p450-like protein 0.0018 0.0033 0.0133
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0026 0.0083 0.1677
Echinococcus multilocularis tumor protein p63 0.0666 0.4119 0.4113
Schistosoma mansoni microtubule-associated protein tau 0.0697 0.4313 1
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0044 0.0194 0.1099
Plasmodium falciparum 26S proteasome regulatory subunit RPN13, putative 0.028 0.1685 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0153 0.0334
Loa Loa (eye worm) hypothetical protein 0.0074 0.0384 0.1134
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0083 0.0225
Echinococcus granulosus Niemann Pick C1 protein 0.0146 0.0839 0.1928
Loa Loa (eye worm) hypothetical protein 0.0054 0.0256 0.0749
Brugia malayi hypothetical protein 0.0016 0.002 0.0033
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.1729 0.5325
Echinococcus granulosus polycomb protein SCMH1 0.0049 0.0228 0.0509
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0067 0.0175
Echinococcus granulosus ecdysone induced protein 78C 0.0031 0.0112 0.0239
Loa Loa (eye worm) hypothetical protein 0.0026 0.0079 0.0211
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0037 0.0085
Brugia malayi Latrophilin receptor protein 2 0.0098 0.0536 0.1596
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0026 0.0083 0.0436
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0037 0.0065
Echinococcus multilocularis FTZ F1 alpha 0.0031 0.0112 0.0103
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0083 0.0225
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0098 0.0536 0.1596
Loa Loa (eye worm) hypothetical protein 0.0031 0.0112 0.0311
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.014 0.0803 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0138 0.0394
Loa Loa (eye worm) hypothetical protein 0.031 0.1872 0.5643
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0031 0.0112 0.0311
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0034 0.0075
Trypanosoma brucei proteasome complex subunit Rpn13 ubiquitin receptor, putative 0.0084 0.0446 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.0199 0.0574
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0112 0.0103
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0153 0.0334
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0037 0.0833
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0074 0.1654
Echinococcus granulosus dna polymerase eta 0.0044 0.0195 0.0432
Echinococcus granulosus adhesion regulating molecule 1 0.0538 0.331 0.767
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0122 0.0113
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0049 0.0228 0.105
Schistosoma mansoni intermediate filament proteins 0.0055 0.0265 0.0594
Echinococcus granulosus SAM and MBT domain containing protein 0.0049 0.0228 0.0509
Echinococcus multilocularis lamin 0.0055 0.0265 0.0256
Loa Loa (eye worm) MH2 domain-containing protein 0.0237 0.1413 0.4253
Echinococcus multilocularis adhesion regulating molecule 1 0.0538 0.331 0.3304
Echinococcus granulosus Niemann Pick C1 protein 0.0102 0.0562 0.1285
Giardia lamblia GTOR 0.0044 0.0194 0.0929
Brugia malayi Isocitrate dehydrogenase 0.0032 0.0122 0.0341
Echinococcus granulosus geminin 0.0364 0.2215 0.5126
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.1729 0.5325
Brugia malayi N-terminal motif family protein 0.0179 0.1049 0.3151
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0081 0.022
Schistosoma mansoni lamin 0.0055 0.0265 0.0594
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0153 0.3277
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0031 0.0112 0.0239
Schistosoma mansoni smad1 5 8 and 0.0016 0.0019 0.0024
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0037 0.0153 0.0436
Echinococcus multilocularis flap endonuclease 1 0.0026 0.0083 0.0074
Brugia malayi nuclear receptor RXR 0.0016 0.002 0.0033
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.004 0.0167 0.0486
Schistosoma mansoni hypothetical protein 0.0098 0.0536 0.1224
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0032 0.0122 0.0299
Echinococcus multilocularis thyroid hormone receptor alpha 0.0031 0.0112 0.0103
Schistosoma mansoni smad 0.0016 0.0019 0.0024
Loa Loa (eye worm) hypothetical protein 0.0044 0.0195 0.0563
Schistosoma mansoni hypothetical protein 0.0212 0.1253 0.2891
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0031 0.0112 0.0239
Brugia malayi Cytochrome P450 family protein 0.0018 0.0033 0.0071
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0153 0.0334
Loa Loa (eye worm) hypothetical protein 0.0016 0.002 0.0033
Echinococcus granulosus histone lysine methyltransferase setb 0.0018 0.003 0.0048
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.002 0.0026
Trypanosoma brucei ubiquitin-protein ligase, putative 0.004 0.0167 0.3752
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0037 0.0085
Trichomonas vaginalis glucosylceramidase, putative 0.0527 0.3238 1
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.004 0.0167 0.3604
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0031 0.0112 0.0239
Trichomonas vaginalis glucosylceramidase, putative 0.0346 0.2096 0.6462
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0032 0.0122 0.0262
Echinococcus multilocularis geminin 0.0364 0.2215 0.2208
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.014 0.0803 0.5
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0052 0.0248 0.0722
Entamoeba histolytica hypothetical protein 0.0037 0.0153 0.0685
Brugia malayi nuclear hormone receptor 0.0031 0.0112 0.0311
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0035 0.0138 0.0762
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0019 0.0024
Brugia malayi Ubiquitin conjugating enzyme protein 13 0.004 0.0167 0.0479
Loa Loa (eye worm) hypothetical protein 0.0179 0.1049 0.3151
Loa Loa (eye worm) CYP4Cod1 0.0018 0.0033 0.0071
Loa Loa (eye worm) MBCTL1 0.0056 0.0271 0.0794
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0037 0.0833
Echinococcus granulosus FTZ F1 alpha 0.0031 0.0112 0.0239
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0031 0.0112 0.0311
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0016 0.002 0.0033
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0031 0.0112 0.0311
Schistosoma mansoni hypothetical protein 0.0098 0.0536 0.1224
Entamoeba histolytica ubiquitin-conjugating enzyme family protein 0.004 0.0167 0.0769
Trichomonas vaginalis glucosylceramidase, putative 0.0527 0.3238 1
Giardia lamblia Flap structure-specific endonuclease 0.0026 0.0083 0.0273
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0112 0.0311
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.004 0.0167 0.0486
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.003 0.0048
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0031 0.0112 0.0239
Echinococcus multilocularis GPCR, family 2 0.0098 0.0536 0.0527
Echinococcus multilocularis isocitrate dehydrogenase 0.0032 0.0122 0.0113
Loa Loa (eye worm) cytochrome P450 family protein 0.0018 0.0033 0.0071
Echinococcus granulosus tumor protein p63 0.0666 0.4119 0.9549
Brugia malayi ecdysteroid receptor 0.0031 0.0112 0.0311
Trichomonas vaginalis glucosylceramidase, putative 0.0346 0.2096 0.6462
Loa Loa (eye worm) hypothetical protein 0.0049 0.0228 0.0664
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0098 0.0536 0.0527
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0527 0.3238 0.9783
Schistosoma mansoni hypothetical protein 0.0364 0.2215 0.5126
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.003 0.0048
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0031 0.0112 0.0311
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0112 0.0311
Brugia malayi MH2 domain containing protein 0.0016 0.0019 0.0031
Schistosoma mansoni smad1 5 8 and 0.0016 0.0019 0.0024
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0031 0.0112 0.0239
Schistosoma mansoni hypothetical protein 0.03 0.1806 0.4176
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0018 0.0032 0.0728
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.003 0.0048
Schistosoma mansoni zinc finger protein 0.0016 0.0018 0.0021
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0044 0.0194 0.4356
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0527 0.3238 0.9783
Schistosoma mansoni lamin 0.0055 0.0265 0.0594
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0067 0.0175
Brugia malayi Bromodomain containing protein 0.0078 0.0412 0.122
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0044 0.0194 0.043
Brugia malayi Cytochrome P450 family protein 0.0018 0.0033 0.0071
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0037 0.016
Toxoplasma gondii adhesion regulating molecule region protein, putative 0.0538 0.331 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0138 0.0394
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0103 0.0288
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0248 0.0239
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0037 0.0833
Echinococcus multilocularis ecdysone induced protein 78C 0.0031 0.0112 0.0103
Brugia malayi Steroid receptor seven-up type 2 0.0031 0.0112 0.0311
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0083 0.0225
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0112 0.0311
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0104 0.0572 0.1308
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0015 0.001 0.0231
Onchocerca volvulus 0.0031 0.0112 0.0492
Loa Loa (eye worm) hypothetical protein 0.0016 0.002 0.0033
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0122 0.0149
Echinococcus granulosus sterol regulatory element binding protein 0.0044 0.0194 0.043
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.1729 0.5325
Trichomonas vaginalis glucosylceramidase, putative 0.0346 0.2096 0.6462
Plasmodium vivax flap endonuclease 1, putative 0.0026 0.0083 0.0259
Schistosoma mansoni hypothetical protein 0.0098 0.0536 0.1224
Echinococcus multilocularis smad 0.0016 0.0019 0.001
Trichomonas vaginalis flap endonuclease-1, putative 0.0026 0.0083 0.0226
Echinococcus multilocularis ubiquitin specific protease 41 0.0037 0.0153 0.0144
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0015 0.001 0.0001
Schistosoma mansoni hypothetical protein 0.0016 0.0018 0.0021
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0031 0.0112 0.0239
Echinococcus granulosus histone acetyltransferase MYST2 0.0056 0.0271 0.0609
Loa Loa (eye worm) hypothetical protein 0.0043 0.0186 0.0536
Brugia malayi mbt repeat family protein 0.0049 0.0228 0.0664
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.004 0.0167 0.3604
Schistosoma mansoni adhesion regulating molecule 1 (110 kD cell membrane glycoprotein) 0.0538 0.331 0.767
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0037 0.0833
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0123 0.035
Schistosoma mansoni hypothetical protein 0.0042 0.0184 0.0407
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0044 0.0194 0.4223
Brugia malayi Adhesion regulating molecule conserved region family protein 0.0538 0.331 1
Brugia malayi hypothetical protein 0.0016 0.002 0.0033
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0015 0.001 0.0003
Schistosoma mansoni hypothetical protein 0.0364 0.2215 0.5126
Plasmodium falciparum flap endonuclease 1 0.0026 0.0083 0.006
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0016 0.002 0.0026
Trypanosoma cruzi proteasome complex subunit Rpn13 ubiquitin receptor, putative 0.0084 0.0446 1
Trypanosoma brucei DNA polymerase eta, putative 0.0044 0.0195 0.4374
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0194 0.1142 0.2632
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0031 0.0112 0.0239
Brugia malayi MH1 domain containing protein 0.0016 0.0019 0.0031
Leishmania major hypothetical protein, conserved 0.028 0.1685 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0031 0.0112 0.0311
Schistosoma mansoni coup transcription factor 0.0031 0.0112 0.0239
Brugia malayi mbt repeat family protein 0.0049 0.0228 0.0664
Echinococcus granulosus GPCR family 2 0.0098 0.0536 0.1224
Trichomonas vaginalis glucosylceramidase, putative 0.0364 0.2214 0.6826
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.002 0.0033
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0032 0.0122 0.1107
Entamoeba histolytica Flap nuclease, putative 0.0026 0.0083 0.0273
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0112 0.0239
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0049 0.0228 0.0509
Brugia malayi PHD-finger family protein 0.0026 0.0082 0.022
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0044 0.0194 0.056
Loa Loa (eye worm) hypothetical protein 0.004 0.017 0.0488
Loa Loa (eye worm) phosphatidylinositol 3 0.0015 0.001 0.0003
Trypanosoma cruzi DNA polymerase eta, putative 0.0044 0.0195 0.424
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0037 0.0153 0.0685
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0194 0.057
Echinococcus multilocularis Niemann Pick C1 protein 0.0102 0.0562 0.0554
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0067 0.0175
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0044 0.0194 0.0929
Echinococcus granulosus lamin 0.0055 0.0265 0.0594
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0031 0.0112 0.0311
Brugia malayi Cytochrome P450 family protein 0.0046 0.0207 0.06
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0044 0.0194 0.0929
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0031 0.0112 0.0311
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0081 0.022
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0016 0.002 0.0026
Brugia malayi Bromodomain containing protein 0.004 0.017 0.0487
Brugia malayi cytoplasmic intermediate filament protein 0.003 0.0104 0.0286
Schistosoma mansoni myelin transcription factor 1 myt1 0.0056 0.0271 0.0609
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0026 0.0083 0.003
Loa Loa (eye worm) hypothetical protein 0.0212 0.1253 0.3769
Loa Loa (eye worm) hypothetical protein 0.0026 0.0079 0.0211
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0067 0.0175
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0153 0.0442
Loa Loa (eye worm) mbt repeat family protein 0.0049 0.0228 0.0664
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0122 0.0149
Trichomonas vaginalis glucosylceramidase, putative 0.0346 0.2096 0.6462
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0031 0.0112 0.0311
Schistosoma mansoni nuclear hormone receptor 0.0031 0.0112 0.0239
Onchocerca volvulus 0.0055 0.0265 0.1225
Echinococcus multilocularis lamin dm0 0.0055 0.0265 0.0256
Loa Loa (eye worm) hypothetical protein 0.0031 0.0112 0.0311
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0248 0.0554
Schistosoma mansoni steroid hormone receptor ad4bp 0.0031 0.0112 0.0239
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0037 0.0833
Brugia malayi intermediate filament protein 0.0055 0.0265 0.0775
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0019 0.001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0123 0.035
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0015 0.001 0.0231
Brugia malayi Nuclear hormone receptor-like 1 0.0031 0.0112 0.0311
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0112 0.0103
Loa Loa (eye worm) transcription factor SMAD2 0.0237 0.1413 0.4253
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.1729 0.5325
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0074 0.1456
Brugia malayi hypothetical protein 0.0037 0.0153 0.0436
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0102 0.0562 0.3103
Treponema pallidum fructose-bisphosphate aldolase 0.0287 0.1729 0.5
Trichomonas vaginalis glucosylceramidase, putative 0.0527 0.3238 1
Loa Loa (eye worm) steroid hormone receptor 0.0031 0.0112 0.0311
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0154 0.0444
Onchocerca volvulus Proteasomal ubiquitin receptor ADRM1 homolog 0.0342 0.2071 0.988
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0031 0.0112 0.0311
Schistosoma mansoni hypothetical protein 0.0042 0.0184 0.0407
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0037 0.0833
Trypanosoma cruzi proteasome complex subunit Rpn13 ubiquitin receptor, putative 0.0084 0.0446 1
Schistosoma mansoni DNA polymerase eta 0.0044 0.0195 0.0432
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.1729 0.5325
Trichomonas vaginalis glucosylceramidase, putative 0.0346 0.2096 0.6462
Schistosoma mansoni Smad4 0.0016 0.0019 0.0024
Loa Loa (eye worm) hypothetical protein 0.0098 0.0532 0.1585
Echinococcus multilocularis SAM and MBT domain containing protein 0.0049 0.0228 0.0219
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0037 0.0153 0.0334
Brugia malayi latrophilin 2 splice variant baaae 0.0212 0.1253 0.3769
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0037 0.0028
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0153 0.0144
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0037 0.0616
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0032 0.0122 0.2733
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.003 0.0048
Leishmania major hypothetical protein, conserved 0.0016 0.0018 0.0048
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.004 0.0167 0.0479
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0194 0.057
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0037 0.0083
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0031 0.0112 0.0239
Trypanosoma cruzi DNA polymerase eta, putative 0.0031 0.0113 0.2347
Brugia malayi Smad1 0.0016 0.0019 0.0031
Loa Loa (eye worm) Smad1 0.0016 0.0019 0.0031
Loa Loa (eye worm) pigment dispersing factor receptor c 0.031 0.1872 0.5643
Echinococcus multilocularis Niemann Pick C1 protein 0.0146 0.0839 0.083
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0037 0.0833
Loa Loa (eye worm) hypothetical protein 0.0018 0.003 0.0063
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0031 0.0113 0.012
Trypanosoma brucei cytochrome P450, putative 0.0018 0.0033 0.0731
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0138 0.0394
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0112 0.0311
Brugia malayi Flap endonuclease-1 0.0026 0.0083 0.0225
Entamoeba histolytica hypothetical protein 0.0037 0.0153 0.0685
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0194 0.057
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0037 0.0833
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.031 0.1872 0.5643
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0031 0.0112 0.0103
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0044 0.0194 0.4356
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0044 0.0194 0.043
Loa Loa (eye worm) hypothetical protein 0.0016 0.002 0.0033
Echinococcus granulosus Protein patched homolog 1 0.0044 0.0194 0.043
Trypanosoma cruzi proteasome complex subunit Rpn13 ubiquitin receptor, putative 0.0084 0.0446 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0067 0.0175
Trypanosoma cruzi cytochrome P450, putative 0.0018 0.0033 0.0512
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0123 0.035
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.003 0.0048
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0122 0.0113
Schistosoma mansoni zinc finger protein 0.002 0.0047 0.0087
Echinococcus multilocularis microtubule associated protein 2 0.0697 0.4313 0.4308
Leishmania major DNA polymerase eta, putative 0.0044 0.0195 0.1103
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0037 0.0059
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0037 0.0065
Loa Loa (eye worm) isocitrate dehydrogenase 0.0032 0.0122 0.0341
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0067 0.0175
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.1729 0.5325
Schistosoma mansoni ubiquitin conjugating enzyme 13 0.004 0.0167 0.0367
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0153 0.0144
Onchocerca volvulus 0.0049 0.0228 0.105
Brugia malayi nuclear receptor NHR-88 0.0031 0.0112 0.0311
Leishmania major ubiquitin-conjugating enzyme e2, putative 0.004 0.0167 0.0938
Loa Loa (eye worm) hypothetical protein 0.0031 0.0112 0.0311
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0037 0.0153 0.0685
Echinococcus granulosus smad 0.0016 0.0019 0.0024
Echinococcus multilocularis Smad4 0.0016 0.0019 0.001
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0122 0.0113
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0056 0.0271 0.0609
Loa Loa (eye worm) hypothetical protein 0.0031 0.0112 0.0311
Brugia malayi steroid hormone receptor 0.0031 0.0112 0.0311
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0016 0.002 0.0011
Loa Loa (eye worm) hypothetical protein 0.0055 0.0265 0.0775

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = 23 % In vitro inhibition of acid induced swelling in rat platelets by 50% as a measure of NHE inhibition ChEMBL. 12086486

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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