Detailed information for compound 1715876

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 465.489 | Formula: C27H25F2NO4
  • H donors: 1 H acceptors: 1 LogP: 5.62 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(c(c1)F)Nc1ccc2c(c1)CCc1c(C2=O)ccc(c1)OC[C@H]1COC(O1)(C)C
  • InChi: 1S/C27H25F2NO4/c1-27(2)33-15-21(34-27)14-32-20-7-9-23-17(12-20)4-3-16-11-19(6-8-22(16)26(23)31)30-25-10-5-18(28)13-24(25)29/h5-13,21,30H,3-4,14-15H2,1-2H3/t21-/m0/s1
  • InChiKey: BSJHGNQUVPKGIL-NRFANRHFSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens mitogen-activated protein kinase 14 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma cruzi mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Leishmania braziliensis mitogen-activated protein kinase 3, putative,map kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus multilocularis mitogen activated protein kinase 14 Get druggable targets OG5_128610 All targets in OG5_128610
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus multilocularis mitogen activated protein kinase 14 Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus granulosus mitogen activated protein kinase 11 Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus granulosus mitogen activated protein kinase 14 Get druggable targets OG5_128610 All targets in OG5_128610
Candida albicans MAP kinase involved in osmoregulation Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus multilocularis mitogen activated protein kinase 11 Get druggable targets OG5_128610 All targets in OG5_128610
Leishmania mexicana mitogen-activated protein kinase 3, putative,map kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus multilocularis mitogen activated protein kinase 11 Get druggable targets OG5_128610 All targets in OG5_128610
Trypanosoma cruzi mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Trypanosoma congolense mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Candida albicans MAP kinase involved in osmoregulation Get druggable targets OG5_128610 All targets in OG5_128610
Schistosoma japonicum ko:K04441 p38 MAP kinase, putative Get druggable targets OG5_128610 All targets in OG5_128610
Brugia malayi P38 map kinase family protein 2 Get druggable targets OG5_128610 All targets in OG5_128610
Leishmania infantum mitogen-activated protein kinase 3, putative,map kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Trypanosoma brucei mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Trypanosoma brucei gambiense mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Leishmania donovani mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase Get druggable targets OG5_128610 All targets in OG5_128610
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 mitogen-activated protein kinase 14 360 aa 336 aa 33.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.021 0.0274
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.009 0.0952 0.2339
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0418 0.102
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0098 0.1057 0.2354
Brugia malayi excitatory GABA receptor EXP-1A 0.0024 0.0111 0.0249
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0052 0.0472 0.1044
Loa Loa (eye worm) hypothetical protein 0.0024 0.0111 0.023
Echinococcus granulosus neuropeptide receptor 0.009 0.0952 0.1263
Echinococcus multilocularis g protein coupled receptor 0.009 0.0952 0.0947
Loa Loa (eye worm) G-protein coupled receptor 0.009 0.0952 0.2046
Brugia malayi Serotonin receptor 0.009 0.0952 0.2128
Brugia malayi hypothetical protein 0.0031 0.0197 0.0441
Echinococcus granulosus follistatin 0.0019 0.0038 0.0044
Onchocerca volvulus 0.0052 0.0472 0.1705
Loa Loa (eye worm) Smad1 0.0017 0.001 0.0011
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0024 0.0111 0.0263
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0228 0.2732 0.6734
Echinococcus multilocularis G-protein coupled receptor, putative 0.009 0.0952 0.0947
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0038 0.0283 0.0623
Schistosoma mansoni neuropeptide receptor 0.009 0.0952 0.2339
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0016 0.0007 0.0011
Onchocerca volvulus 0.0052 0.0472 0.1705
Brugia malayi Tachykinin-like peptides receptor 99D 0.009 0.0952 0.2128
Schistosoma mansoni hypothetical protein 0.0035 0.0251 0.0607
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.028 0.3402 0.7602
Echinococcus granulosus g protein coupled receptor 0.009 0.0952 0.1263
Schistosoma mansoni biogenic amine receptor 0.009 0.0952 0.2339
Leishmania major cytochrome p450-like protein 0.0019 0.0039 0.0076
Brugia malayi neuropeptide F receptor 0.009 0.0952 0.2128
Trypanosoma brucei cysteine peptidase C (CPC) 0.0098 0.1057 0.2354
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0052 0.0472 0.0467
Loa Loa (eye worm) hypothetical protein 0.009 0.0952 0.2046
Entamoeba histolytica cysteine proteinase, putative 0.0038 0.0283 0.5946
Echinococcus multilocularis g protein coupled receptor 0.009 0.0952 0.0947
Echinococcus multilocularis a disintegrin and metalloproteinase with 0.0084 0.0884 0.0879
Loa Loa (eye worm) hypothetical protein 0.009 0.0952 0.2046
Schistosoma mansoni hypothetical protein 0.0069 0.069 0.1692
Brugia malayi Trypsin family protein 0.0098 0.1056 0.236
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.009 0.0952 0.2046
Brugia malayi cathepsin Z-like cysteine proteinase 0.0016 0.0007 0.0016
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0016 0.0007 0.0011
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.009 0.0952 0.1263
Loa Loa (eye worm) hypothetical protein 0.0024 0.0111 0.023
Plasmodium vivax vivapain-2 0.0052 0.0472 0.2424
Schistosoma mansoni nAChR subunit 0.0024 0.0111 0.0263
Loa Loa (eye worm) fibroinase 0.0052 0.0472 0.1008
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.069 0.1543
Echinococcus multilocularis histone deacetylase 7 0.0166 0.193 0.1926
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0016 0.0007 0.0005
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0024 0.0111 0.0106
Schistosoma mansoni histone deacetylase hda2 0.0166 0.193 0.4754
Loa Loa (eye worm) hypothetical protein 0.009 0.0952 0.2046
Loa Loa (eye worm) hypothetical protein 0.009 0.0952 0.2046
Brugia malayi metalloprotease disintegrin 16 with thrombospondin type I motif 0.0084 0.0884 0.1976
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0045 0.0374 0.091
Brugia malayi hypothetical protein 0.0027 0.015 0.0335
Schistosoma mansoni smad1 5 8 and 0.0017 0.001 0.0013
Echinococcus granulosus adam 0.0031 0.0197 0.0256
Echinococcus granulosus mitogen activated protein kinase 11 0.0152 0.1754 0.2334
Mycobacterium tuberculosis Probable peptidase 0.0052 0.0461 0.3369
Onchocerca volvulus 0.0027 0.015 0.0523
Onchocerca volvulus 0.0027 0.015 0.0523
Onchocerca volvulus 0.009 0.0952 0.3468
Onchocerca volvulus 0.009 0.0952 0.3468
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0363 0.4473 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.009 0.0952 0.0947
Loa Loa (eye worm) hypothetical protein 0.0024 0.0111 0.023
Loa Loa (eye worm) calpain family protein 1 0.0032 0.0203 0.0428
Entamoeba histolytica cysteine protease, putative 0.0052 0.0472 1
Schistosoma mansoni alpha-1 adrenergic receptor 0.009 0.0952 0.2339
Loa Loa (eye worm) hypothetical protein 0.0027 0.0141 0.0293
Loa Loa (eye worm) transcription factor SMAD2 0.0243 0.2926 0.6309
Echinococcus granulosus cysteine protease 0.0031 0.0196 0.0254
Brugia malayi hypothetical protein 0.009 0.0952 0.2128
Brugia malayi Cathepsin L-like precursor 0.0052 0.0472 0.1054
Loa Loa (eye worm) hypothetical protein 0.0027 0.015 0.0313
Schistosoma mansoni dihydroceramide desaturase 0.0018 0.0027 0.0053
Loa Loa (eye worm) hypothetical protein 0.009 0.0952 0.2046
Leishmania major C-8 sterol isomerase-like protein 0.0363 0.4473 1
Loa Loa (eye worm) hypothetical protein 0.009 0.0952 0.2046
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0016 0.0007 0.0011
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0098 0.1057 1
Echinococcus multilocularis G protein coupled receptor 139 0.009 0.0952 0.0947
Onchocerca volvulus 0.0027 0.015 0.0523
Echinococcus multilocularis rhodopsin orphan GPCR 0.009 0.0952 0.0947
Brugia malayi hypothetical protein 0.0027 0.015 0.0335
Schistosoma mansoni smad 0.0017 0.001 0.0013
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0024 0.0111 0.023
Loa Loa (eye worm) hypothetical protein 0.009 0.0952 0.2046
Echinococcus granulosus histone deacetylase 6 0.0166 0.193 0.2568
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0472 0.4425
Schistosoma mansoni amine GPCR 0.009 0.0952 0.2339
Loa Loa (eye worm) hypothetical protein 0.0027 0.015 0.0313
Loa Loa (eye worm) neuropeptide F receptor 0.009 0.0952 0.2046
Echinococcus granulosus neuropeptide Y receptor 0.009 0.0952 0.1263
Loa Loa (eye worm) hypothetical protein 0.009 0.0952 0.2046
Echinococcus multilocularis rhodopsin orphan GPCR 0.009 0.0952 0.0947
Schistosoma mansoni rhodopsin-like orphan GPCR 0.009 0.0952 0.2339
Loa Loa (eye worm) hypothetical protein 0.009 0.0952 0.2046
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0024 0.0111 0.0263
Loa Loa (eye worm) hypothetical protein 0.0363 0.4473 0.9653
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.0472 0.4425
Toxoplasma gondii kringle domain-containing protein 0.0035 0.0251 0.1267
Echinococcus granulosus cytochrome P450 2K1 0.0019 0.0039 0.0045
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0024 0.0111 0.0142
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0111 0.0238
Entamoeba histolytica cysteine protease, putative 0.0031 0.0196 0.4054
Echinococcus multilocularis neuropeptide receptor A26 0.009 0.0952 0.0947
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.009 0.0952 0.2128
Plasmodium vivax vivapain-3 0.0031 0.0196 0.0989
Schistosoma mansoni neuropeptide receptor 0.009 0.0952 0.2339
Loa Loa (eye worm) follicle stimulating hormone receptor 0.009 0.0952 0.2046
Echinococcus granulosus prolyl endopeptidase 0.013 0.1466 0.195
Loa Loa (eye worm) hypothetical protein 0.009 0.0952 0.2046
Echinococcus multilocularis glycine receptor subunit beta 0.0024 0.0111 0.0106
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.009 0.0952 0.1263
Brugia malayi sulfakinin receptor protein 0.009 0.0952 0.2128
Entamoeba histolytica cysteine proteinase, putative 0.0031 0.0196 0.4054
Schistosoma mansoni ADAMTS5 peptidase (M12 family) 0.0084 0.0884 0.2171
Loa Loa (eye worm) hypothetical protein 0.0024 0.0111 0.023
Onchocerca volvulus 0.009 0.0952 0.3468
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0111 0.0542
Loa Loa (eye worm) hypothetical protein 0.009 0.0952 0.2046
Schistosoma mansoni amine GPCR 0.009 0.0952 0.2339
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0024 0.0111 0.0106
Onchocerca volvulus 0.0052 0.0472 0.1705
Echinococcus granulosus neuropeptide FF receptor 2 0.009 0.0952 0.1263
Echinococcus multilocularis geminin 0.0331 0.4054 0.4051
Loa Loa (eye worm) hypothetical protein 0.0228 0.2732 0.589
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0052 0.0461 1
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0016 0.0007 0.0011
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0031 0.0196 0.0426
Toxoplasma gondii cathepsin B 0.0098 0.1057 0.546
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0052 0.0472 0.1044
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0283 0.2631
Leishmania major cathepsin L-like protease 0.0052 0.0472 0.1044
Echinococcus multilocularis cathepsin L 0.0031 0.0196 0.019
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0472 0.4425
Brugia malayi MH1 domain containing protein 0.0017 0.001 0.0023
Schistosoma mansoni amine GPCR 0.009 0.0952 0.2339
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0018 0.0027 0.0053
Brugia malayi G protein-coupled receptor F59B2.13 0.009 0.0952 0.2128
Schistosoma mansoni hypothetical protein 0.0032 0.021 0.0507
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0019 0.0039 0.0076
Echinococcus granulosus neuropeptide receptor 0.009 0.0952 0.1263
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.021 0.047
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.009 0.0952 0.2046
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.009 0.0952 0.0947
Echinococcus multilocularis serotonin receptor 0.009 0.0952 0.0947
Schistosoma mansoni histone deacetylase 4 5 0.0166 0.193 0.4754
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0283 0.2631
Onchocerca volvulus 0.009 0.0952 0.3468
Loa Loa (eye worm) hypothetical protein 0.009 0.0952 0.2046
Echinococcus multilocularis rhodopsin orphan GPCR 0.009 0.0952 0.0947
Schistosoma mansoni ADAM17 peptidase (M12 family) 0.0179 0.2099 0.5172
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0016 0.0007 0.0005
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0024 0.0111 0.023
Echinococcus granulosus disintegrin and metalloproteinase 0.0018 0.0027 0.0029
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0102 0.1103 0.2373
Loa Loa (eye worm) histone deacetylase 0.0166 0.193 0.4158
Echinococcus multilocularis prolyl endopeptidase 0.013 0.1466 0.1462
Loa Loa (eye worm) histone deacetylase 7A 0.0166 0.193 0.4158
Onchocerca volvulus Putative organic anion transporter 0.0027 0.015 0.0523
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0024 0.0111 0.0106
Trypanosoma brucei histone deacetylase, putative 0.0166 0.193 0.4308
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0024 0.0111 0.0142
Entamoeba histolytica cysteine proteinase 2 0.0031 0.0196 0.4054
Schistosoma mansoni rhodopsin-like orphan GPCR 0.009 0.0952 0.2339
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0024 0.0111 0.0249
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0024 0.0111 0.0249
Echinococcus multilocularis cathepsin b 0.028 0.3402 0.3398
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0024 0.0111 0.0249
Brugia malayi MH1 domain containing protein 0.0017 0.001 0.0023
Plasmodium vivax vivapain-1 0.0031 0.0196 0.0989
Loa Loa (eye worm) hypothetical protein 0.009 0.0952 0.2046
Loa Loa (eye worm) hypothetical protein 0.0038 0.0286 0.0607
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0024 0.0111 0.0249
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0004
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.028 0.3402 0.8389
Schistosoma mansoni rhodopsin-like orphan GPCR 0.009 0.0952 0.2339
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0418 0.0413
Echinococcus granulosus Smad4 0.0017 0.001 0.0007
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.001 0.0011
Echinococcus granulosus g-protein coupled receptor 0.009 0.0952 0.1263
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0598 0.75 0.7498
Echinococcus granulosus rhodopsin orphan GPCR 0.009 0.0952 0.1263
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0031 0.0196 0.0426
Brugia malayi hypothetical protein 0.009 0.0952 0.2128
Echinococcus granulosus tm gpcr rhodopsin 0.0598 0.75 1
Brugia malayi Dopamine receptor protein 2 0.009 0.0952 0.2128
Entamoeba histolytica cysteine protease, putative 0.0031 0.0196 0.4054
Loa Loa (eye worm) hypothetical protein 0.0038 0.0283 0.0601
Echinococcus granulosus 7tm_1 domain containing protein 0.009 0.0952 0.1263
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0024 0.0111 0.0106
Echinococcus multilocularis calpain family protein 1, d 0.0032 0.0203 0.0198
Brugia malayi Cation transporter family protein 0.0024 0.0111 0.0249
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0016 0.0007 0.0005
Loa Loa (eye worm) hypothetical protein 0.009 0.0952 0.2046
Trypanosoma cruzi cruzipain precursor, putative 0.0052 0.0472 0.1044
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0024 0.0111 0.0249
Brugia malayi Cathepsin L-like precursor 0.0052 0.0472 0.1054
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0418 0.0413
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0024 0.0111 0.0106
Loa Loa (eye worm) hypothetical protein 0.009 0.0952 0.2046
Loa Loa (eye worm) hypothetical protein 0.009 0.0952 0.2046
Brugia malayi fibroinase precursor 0.0016 0.0007 0.0016
Onchocerca volvulus 0.009 0.0952 0.3468
Schistosoma mansoni rhodopsin-like orphan GPCR 0.009 0.0952 0.2339
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0024 0.0111 0.0263
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.009 0.0952 0.2339
Schistosoma mansoni agrin 0.0019 0.0038 0.0081
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.001 0.0005
Onchocerca volvulus 0.009 0.0952 0.3468
Echinococcus multilocularis neuropeptides capa receptor 0.009 0.0952 0.0947
Echinococcus multilocularis cathepsin b 0.028 0.3402 0.3398
Echinococcus granulosus neuropeptides capa receptor 0.009 0.0952 0.1263
Echinococcus granulosus fmrfamide receptor 0.009 0.0952 0.1263
Onchocerca volvulus 0.009 0.0952 0.3468
Schistosoma mansoni neuropeptide receptor 0.009 0.0952 0.2339
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0052 0.0472 0.1044
Loa Loa (eye worm) hypothetical protein 0.013 0.1466 0.3157
Echinococcus granulosus geminin 0.0331 0.4054 0.5402
Loa Loa (eye worm) hypothetical protein 0.0098 0.1056 0.227
Loa Loa (eye worm) hypothetical protein 0.0027 0.015 0.0313
Brugia malayi cathepsin F-like cysteine proteinase 0.0016 0.0007 0.0016
Entamoeba histolytica cysteine protease, putative 0.0031 0.0196 0.4054
Brugia malayi N-terminal motif family protein 0.0175 0.2048 0.4579
Loa Loa (eye worm) hypothetical protein 0.0024 0.0111 0.023
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.009 0.0952 0.0947
Brugia malayi Melatonin receptor type 1A 0.009 0.0952 0.2128
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0016 0.0007 0.0005
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.0472 0.4425
Entamoeba histolytica cysteine protease, putative 0.0031 0.0196 0.4054
Brugia malayi hypothetical protein 0.009 0.0952 0.2128
Echinococcus multilocularis GPCR, family 2 0.0032 0.021 0.0205
Trypanosoma brucei histone deacetylase 4 0.0166 0.193 0.4308
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0024 0.0111 0.0249
Schistosoma mansoni smad1 5 8 and 0.0017 0.001 0.0013
Echinococcus multilocularis adam 0.0031 0.0197 0.0192
Loa Loa (eye worm) ctsf protein 0.0052 0.0472 0.1008
Schistosoma mansoni nAChR subunit 0.0024 0.0111 0.0263
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0052 0.0461 0.3369
Echinococcus granulosus tissue type plasminogen activator 0.0035 0.0251 0.0328
Schistosoma mansoni biogenic amine (5HT) receptor 0.009 0.0952 0.2339
Trypanosoma cruzi cytochrome P450, putative 0.0037 0.0278 0.0611
Echinococcus granulosus rhodopsin orphan GPCR 0.009 0.0952 0.1263
Loa Loa (eye worm) hypothetical protein 0.0024 0.0111 0.023
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0418 0.0551
Entamoeba histolytica cysteine proteinase, putative 0.0052 0.0472 1
Loa Loa (eye worm) hypothetical protein 0.0069 0.069 0.148
Loa Loa (eye worm) hypothetical protein 0.009 0.0952 0.2046
Echinococcus multilocularis neuropeptide s receptor 0.009 0.0952 0.0947
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0052 0.0472 0.2416
Brugia malayi RE15519p 0.009 0.0952 0.2128
Loa Loa (eye worm) hypothetical protein 0.009 0.0952 0.2046
Schistosoma mansoni neuropeptide F-like receptor 0.009 0.0952 0.2339
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0004
Brugia malayi Protein kinase domain containing protein 0.0035 0.0251 0.0561
Loa Loa (eye worm) hypothetical protein 0.009 0.0952 0.2046
Loa Loa (eye worm) LGC-31 protein 0.0024 0.0111 0.023
Schistosoma mansoni nAChR subunit 0.0024 0.0111 0.0263
Schistosoma mansoni adenoreceptor 0.009 0.0952 0.2339
Schistosoma mansoni biogenic amine (5HT) receptor 0.009 0.0952 0.2339
Loa Loa (eye worm) hypothetical protein 0.009 0.0952 0.2046
Echinococcus multilocularis cysteine protease 0.0052 0.0472 0.0467
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0052 0.0472 0.1044
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0024 0.0111 0.0263
Echinococcus granulosus cathepsin l1 0.0052 0.0472 0.0623
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.009 0.0952 0.2128
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0016 0.0007 0.0011
Toxoplasma gondii histone deacetylase HDAC1 0.0166 0.193 1
Brugia malayi secreted modular calcium-binding protein 1 0.0019 0.0038 0.0085
Brugia malayi hypothetical protein 0.009 0.0952 0.2128
Onchocerca volvulus 0.0024 0.0111 0.0383
Echinococcus multilocularis rhodopsin orphan GPCR 0.009 0.0952 0.0947
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0472 0.4425
Echinococcus granulosus 7TM GPCR rhodopsin 0.009 0.0952 0.1263
Leishmania major oligopeptidase b 0.0052 0.0461 0.102
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0004
Echinococcus granulosus organic anion transporting polypeptide 30B 0.0027 0.015 0.0193
Loa Loa (eye worm) hypothetical protein 0.0024 0.0111 0.023
Giardia lamblia Cathepsin B precursor 0.0098 0.1057 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.0007 0.0004
Loa Loa (eye worm) reprolysin 0.0018 0.0027 0.0046
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0019 0.0038 0.016
Loa Loa (eye worm) hypothetical protein 0.0032 0.021 0.0444
Loa Loa (eye worm) hypothetical protein 0.0024 0.0111 0.023
Echinococcus granulosus somatostatin receptor 0.009 0.0952 0.1263
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0019 0.0038 0.0085
Schistosoma mansoni nAChR subunit 0.0024 0.0111 0.0263
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0024 0.0111 0.0249
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0472 0.4425
Loa Loa (eye worm) hypothetical protein 0.0052 0.0472 0.1008
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.009 0.0952 0.1263
Echinococcus granulosus a disintegrin and metalloproteinase with 0.0084 0.0884 0.1173
Loa Loa (eye worm) hypothetical protein 0.009 0.0952 0.2046
Echinococcus granulosus glycine receptor subunit alpha 1 0.0024 0.0111 0.0142
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0024 0.0111 0.0106
Onchocerca volvulus 0.009 0.0952 0.3468
Brugia malayi gonadotropin-releasing hormone receptor 2 0.009 0.0952 0.2128
Loa Loa (eye worm) ACC-1 protein 0.0024 0.0111 0.023
Loa Loa (eye worm) hypothetical protein 0.0024 0.0111 0.023
Brugia malayi Cathepsin L-like precursor 0.0038 0.0283 0.0634
Loa Loa (eye worm) hypothetical protein 0.0038 0.0283 0.0601
Trypanosoma cruzi cysteine proteinase, putative 0.0031 0.0196 0.0426
Echinococcus multilocularis allatostatin A receptor 0.0228 0.2732 0.2728
Brugia malayi Cathepsin L-like precursor 0.0052 0.0472 0.1054
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0019 0.0038 0.016
Schistosoma mansoni organic anion transporter 0.0027 0.015 0.0357
Brugia malayi hypothetical protein 0.009 0.0952 0.2128
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0472 0.4425
Brugia malayi Disintegrin family protein 0.0018 0.0027 0.0059
Onchocerca volvulus 0.0027 0.0141 0.049
Loa Loa (eye worm) G-protein coupled receptor 0.009 0.0952 0.2046
Trypanosoma cruzi cysteine protease, putative 0.0031 0.0196 0.0426
Schistosoma mansoni growth hormone secretagogue receptor 0.009 0.0952 0.2339
Onchocerca volvulus 0.0035 0.0251 0.0894
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0031 0.0196 0.1794
Echinococcus multilocularis fmrfamide receptor 0.009 0.0952 0.0947
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.0472 0.4425
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0031 0.0196 0.0426
Loa Loa (eye worm) hypothetical protein 0.009 0.0952 0.2046
Loa Loa (eye worm) hypothetical protein 0.0032 0.0203 0.0428
Echinococcus granulosus dro:myosuppressin receptor 0.009 0.0952 0.1263
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.0018 0.0027 0.0021
Onchocerca volvulus 0.0027 0.015 0.0523
Loa Loa (eye worm) hypothetical protein 0.009 0.0952 0.2046
Entamoeba histolytica cysteine protease, putative 0.0031 0.0196 0.4054
Plasmodium falciparum cysteine proteinase falcipain 1 0.0031 0.0196 0.0979
Onchocerca volvulus 0.0024 0.0111 0.0383
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.028 0.3402 0.8389
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.021 0.0205
Onchocerca volvulus 0.009 0.0952 0.3468
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0024 0.0111 0.0263
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0024 0.0111 0.0142
Brugia malayi Cation transporter family protein 0.0024 0.0111 0.0249
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.009 0.0952 0.2339
Schistosoma mansoni hypothetical protein 0.009 0.0952 0.2339
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0024 0.0111 0.0249
Schistosoma mansoni biogenic amine (dopamine) receptor 0.009 0.0952 0.2339
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0024 0.0111 0.0142
Brugia malayi Latrophilin receptor protein 2 0.0032 0.021 0.047
Schistosoma mansoni cathepsin B (C01 family) 0.0016 0.0007 0.0005
Brugia malayi hypothetical protein 0.009 0.0952 0.2128
Brugia malayi Papain family cysteine protease containing protein 0.0031 0.0196 0.0437
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0019 0.0039 0.0076
Brugia malayi neuropeptide F receptor 0.009 0.0952 0.2128
Echinococcus multilocularis cathepsin L cysteine protease 0.0052 0.0472 0.0467
Loa Loa (eye worm) hypothetical protein 0.0035 0.0251 0.0531
Loa Loa (eye worm) hypothetical protein 0.009 0.0952 0.2046
Echinococcus multilocularis expressed protein 0.0019 0.0038 0.0033
Echinococcus multilocularis sex peptide receptor 0.009 0.0952 0.0947
Entamoeba histolytica cysteine protease, putative 0.0031 0.0196 0.4054
Brugia malayi Cathepsin L-like precursor 0.0052 0.0472 0.1054
Entamoeba histolytica cysteine protease, putative 0.0031 0.0196 0.4054
Entamoeba histolytica cysteine proteinase, putative 0.0031 0.0196 0.4054
Echinococcus multilocularis rhodopsin orphan GPCR 0.009 0.0952 0.0947
Echinococcus multilocularis neuropeptide receptor 0.009 0.0952 0.0947
Entamoeba histolytica cysteine protease, putative 0.0031 0.0196 0.4054
Schistosoma mansoni neuropeptide F-like receptor 0.009 0.0952 0.2339
Onchocerca volvulus 0.009 0.0952 0.3468
Trypanosoma cruzi cysteine proteinase, putative 0.0031 0.0196 0.0426
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0016 0.0007 0.0005
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0024 0.0111 0.0249
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0418 0.102
Brugia malayi Papain family cysteine protease containing protein 0.0052 0.0472 0.1054
Echinococcus multilocularis cathepsin L cysteine protease 0.0052 0.0472 0.0467
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.009 0.0952 0.2128
Onchocerca volvulus 0.0019 0.0038 0.0113
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0418 0.0551
Plasmodium vivax vivapain-2 0.0052 0.0472 0.2424
Brugia malayi cathepsin Z-like cysteine proteinase 0.0016 0.0007 0.0016
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0472 0.4425
Brugia malayi Serotonin receptor 0.009 0.0952 0.2128
Trypanosoma cruzi oligopeptidase b 0.0052 0.0461 0.102
Loa Loa (eye worm) hypothetical protein 0.0027 0.015 0.0313
Leishmania major cytochrome p450-like protein 0.0019 0.0039 0.0076
Brugia malayi AKH receptor 0.009 0.0952 0.2128
Trypanosoma cruzi prolyl endopeptidase 0.013 0.1466 0.327
Trypanosoma cruzi cysteine peptidase, putative 0.0031 0.0196 0.0426
Onchocerca volvulus 0.009 0.0952 0.3468
Onchocerca volvulus 0.0024 0.0111 0.0383
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0098 0.1057 0.2354
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0035 0.0251 0.1277
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.0418 0.0892
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0043 0.0349 0.0848
Plasmodium falciparum histone deacetylase 2 0.0166 0.193 1
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.013 0.1466 0.3609
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.009 0.0952 0.0947
Brugia malayi hypothetical protein 0.009 0.0952 0.2128
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0052 0.0461 0.102
Brugia malayi Cytochrome P450 family protein 0.0019 0.0039 0.0087
Echinococcus granulosus biogenic amine 5HT receptor 0.009 0.0952 0.1263
Loa Loa (eye worm) hypothetical protein 0.0019 0.0036 0.0068
Entamoeba histolytica cysteine proteinase 1, putative 0.0031 0.0196 0.4054
Echinococcus granulosus cathepsin L cysteine protease 0.0031 0.0196 0.0254
Loa Loa (eye worm) hypothetical protein 0.0024 0.0111 0.023
Loa Loa (eye worm) hypothetical protein 0.009 0.0952 0.2046
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.009 0.0952 0.0947
Brugia malayi SPARC precursor 0.0019 0.0038 0.0085
Giardia lamblia Cathepsin B precursor 0.0098 0.1057 1
Echinococcus multilocularis nAChR subunit 0.0024 0.0111 0.0106
Leishmania major cysteine peptidase A (CPA) 0.0052 0.0472 0.1044
Loa Loa (eye worm) hypothetical protein 0.0024 0.0111 0.023
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0052 0.0472 0.1008
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0045 0.0374 0.0492
Echinococcus multilocularis rhodopsin orphan GPCR 0.009 0.0952 0.0947
Loa Loa (eye worm) hypothetical protein 0.009 0.0952 0.2046
Schistosoma mansoni biogenic amine (dopamine) receptor 0.009 0.0952 0.2339
Echinococcus multilocularis dro:myosuppressin receptor 0.009 0.0952 0.0947
Toxoplasma gondii transporter, major facilitator family protein 0.0027 0.015 0.0742
Loa Loa (eye worm) hypothetical protein 0.009 0.0952 0.2046
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.021 0.0205
Schistosoma mansoni organic anion transporter 0.0027 0.015 0.0357
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.001 0.0011
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0024 0.0111 0.0249
Echinococcus granulosus Solute carrier organic anion transporter family 0.0027 0.015 0.0193
Trypanosoma brucei oligopeptidase b 0.0052 0.0461 0.102
Loa Loa (eye worm) hypothetical protein 0.009 0.0952 0.2046
Toxoplasma gondii protease inhibitor PI2 0.0019 0.0038 0.016
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0031 0.0196 0.047
Brugia malayi G-protein coupled receptor 0.009 0.0952 0.2128
Trypanosoma cruzi histone deacetylase, putative 0.0166 0.193 0.4308
Echinococcus granulosus cathepsin b 0.028 0.3402 0.4532
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.013 0.1466 0.327
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.001 0.0005
Onchocerca volvulus 0.0024 0.0111 0.0383
Schistosoma mansoni smad1 5 8 and 0.0017 0.001 0.0013
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0052 0.0461 0.102
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0102 0.1103 0.2467
Echinococcus granulosus cathepsin L 0.0016 0.0007 0.0003
Loa Loa (eye worm) hypothetical protein 0.0376 0.4634 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0052 0.0472 0.1044
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0016 0.0007 0.0011
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.001 0.0007
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0019 0.0039 0.0076
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0024 0.0111 0.0142
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0052 0.0472 0.2416
Plasmodium vivax serine-repeat antigen (SERA) 0.0016 0.0007 0.0011
Trypanosoma cruzi cysteine peptidase, putative 0.0052 0.0472 0.1044
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.009 0.0952 0.2339
Plasmodium falciparum histone deacetylase, putative 0.0166 0.193 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0038 0.0071
Onchocerca volvulus 0.0038 0.0283 0.1014
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0325 0.3977 0.3974
Echinococcus granulosus g protein coupled receptor 0.009 0.0952 0.1263
Plasmodium vivax unspecified product 0.0016 0.0007 0.0011
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.009 0.0952 0.2339
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0004
Brugia malayi Cathepsin L-like precursor 0.0038 0.0283 0.0634
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0019 0.0038 0.016
Onchocerca volvulus 0.009 0.0952 0.3468
Schistosoma mansoni biogenic amine receptor 0.009 0.0952 0.2339
Toxoplasma gondii prolyl endopeptidase 0.013 0.1466 0.7589
Loa Loa (eye worm) hypothetical protein 0.0166 0.193 0.4158
Trypanosoma brucei histone deacetylase 3 0.0166 0.193 0.4308
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0052 0.0472 0.1008
Echinococcus multilocularis mitogen activated protein kinase 14 0.0152 0.1754 0.175
Loa Loa (eye worm) hypothetical protein 0.0102 0.1103 0.2373
Echinococcus multilocularis calpain A 0.0045 0.0374 0.0369
Loa Loa (eye worm) hypothetical protein 0.009 0.0952 0.2046
Brugia malayi hypothetical protein 0.009 0.0952 0.2128
Echinococcus granulosus allatostatin A receptor 0.0228 0.2732 0.3638
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0052 0.0472 0.4425
Trypanosoma brucei C-8 sterol isomerase, putative 0.0363 0.4473 1
Schistosoma mansoni cathepsin F (C01 family) 0.0052 0.0472 0.1152
Echinococcus granulosus cathepsin l1 0.0038 0.0283 0.0371
Onchocerca volvulus 0.0024 0.0111 0.0383
Onchocerca volvulus Prolyl endopeptidase homolog 0.013 0.1466 0.5356
Schistosoma mansoni hypothetical protein 0.0331 0.4054 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.009 0.0952 0.1263
Brugia malayi P38 map kinase family protein 2 0.0152 0.1754 0.3922
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0019 0.0039 0.0076
Brugia malayi Histone deacetylase family protein 0.0166 0.193 0.4314
Loa Loa (eye worm) cytochrome P450 family protein 0.0037 0.0278 0.059
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0018 0.0027 0.0053
Schistosoma mansoni hypothetical protein 0.009 0.0952 0.2339
Loa Loa (eye worm) hypothetical protein 0.0024 0.0111 0.023
Loa Loa (eye worm) hypothetical protein 0.0038 0.0283 0.0601
Brugia malayi cathepsin L precursor 0.0016 0.0007 0.0016
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0024 0.0111 0.0263
Onchocerca volvulus Cathepsin F homolog 0.0052 0.0472 0.1705
Brugia malayi Cathepsin L-like precursor 0.0052 0.0472 0.1054
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0024 0.0111 0.0249
Leishmania major histone deacetylase, putative 0.0166 0.193 0.4308
Trypanosoma cruzi major cysteine proteinase, putative 0.0016 0.0007 0.0005
Loa Loa (eye worm) hypothetical protein 0.0027 0.015 0.0313
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0019 0.0038 0.0085
Brugia malayi sodium-independent organic anion transporter family protein 0.0027 0.015 0.0335
Echinococcus granulosus rhodopsin orphan GPCR 0.009 0.0952 0.1263
Echinococcus multilocularis histone deacetylase 6 0.0166 0.193 0.1926
Echinococcus granulosus neuropeptides capa receptor 0.009 0.0952 0.1263
Echinococcus multilocularis glycine receptor subunit beta 0.0024 0.0111 0.0106
Echinococcus granulosus sex peptide receptor 0.009 0.0952 0.1263
Loa Loa (eye worm) agrin synaptic family protein 0.0019 0.0038 0.0071
Echinococcus multilocularis orexin receptor type 2 0.009 0.0952 0.0947
Loa Loa (eye worm) hypothetical protein 0.0166 0.193 0.4158
Loa Loa (eye worm) hypothetical protein 0.0019 0.0038 0.0071
Echinococcus multilocularis mitogen activated protein kinase 14 0.0152 0.1754 0.175
Schistosoma mansoni neuropeptide receptor 0.009 0.0952 0.2339
Echinococcus multilocularis tissue type plasminogen activator 0.0035 0.0251 0.0246
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.021 0.0444
Onchocerca volvulus Putative nachr subunit 0.0024 0.0111 0.0383
Schistosoma mansoni nAChR subunit 0.0024 0.0111 0.0263
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0111 0.0542
Echinococcus multilocularis neuropeptide FF receptor 2 0.009 0.0952 0.0947
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0024 0.0111 0.0142
Schistosoma mansoni opsin-like receptor 0.009 0.0952 0.2339
Schistosoma mansoni biogenic amine (dopamine) receptor 0.009 0.0952 0.2339
Brugia malayi cytochrome P450 0.0019 0.0039 0.0087
Plasmodium falciparum cysteine proteinase falcipain 3 0.0052 0.0472 0.2416
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.009 0.0952 0.2046
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0325 0.3977 0.5299
Echinococcus granulosus hypothetical protein 0.009 0.0952 0.1263
Entamoeba histolytica cysteine proteinase, putative 0.0031 0.0196 0.4054
Brugia malayi putative neuropeptide receptor 0.009 0.0952 0.2128
Trypanosoma cruzi histone deacetylase, putative 0.0166 0.193 0.4308
Brugia malayi Calcitonin receptor-like protein seb-1 0.0102 0.1103 0.2467
Leishmania major cathepsin L-like protease 0.0052 0.0472 0.1044
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0052 0.0472 0.1044
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0052 0.0472 0.1044
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0111 0.0238
Trypanosoma brucei prolyl endopeptidase 0.013 0.1466 0.327
Schistosoma mansoni rhodopsin-like orphan GPCR 0.009 0.0952 0.2339
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0031 0.0196 0.047
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0031 0.0196 0.047
Onchocerca volvulus Neuropeptide F receptor homolog 0.009 0.0952 0.3468
Loa Loa (eye worm) hypothetical protein 0.009 0.0952 0.2046
Leishmania major histone deacetylase, putative 0.0166 0.193 0.4308
Schistosoma mansoni cytochrome P450 0.0019 0.0039 0.0084
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0031 0.0196 0.1794
Echinococcus granulosus glycine receptor subunit alpha 1 0.0024 0.0111 0.0142
Brugia malayi Cytochrome P450 family protein 0.0037 0.0278 0.0622
Brugia malayi Cathepsin L-like cysteine proteinase 0.0038 0.0283 0.0634
Brugia malayi sodium-independent organic anion transporter family protein 0.0027 0.015 0.0335
Loa Loa (eye worm) hypothetical protein 0.009 0.0952 0.2046
Loa Loa (eye worm) hypothetical protein 0.0024 0.0111 0.023
Loa Loa (eye worm) hypothetical protein 0.009 0.0952 0.2046
Brugia malayi cathepsin L-like precursor 0.0038 0.0283 0.0634
Brugia malayi cathepsin B-like cysteine proteinase 0.028 0.3402 0.7604
Loa Loa (eye worm) hypothetical protein 0.009 0.0952 0.2046
Brugia malayi prostaglandin transporter 0.0027 0.015 0.0335
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0007 0.0016
Echinococcus granulosus histone deacetylase 6 0.0166 0.193 0.2568
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.021 0.0274
Brugia malayi calpain 7 0.0016 0.0005 0.0011
Brugia malayi Cytochrome P450 family protein 0.008 0.0822 0.1838
Leishmania major hypothetical protein, conserved 0.0035 0.0251 0.055
Echinococcus granulosus tm gpcr rhodopsin 0.009 0.0952 0.1263
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0251 0.055
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0363 0.4473 1
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0045 0.0374 0.0369
Loa Loa (eye worm) hypothetical protein 0.009 0.0952 0.2046
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0116 0.1291 1
Brugia malayi G-protein coupled receptor 0.009 0.0952 0.2128
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0016 0.0007 0.0011
Brugia malayi Dopamine receptor protein 1 0.009 0.0952 0.2128
Echinococcus multilocularis serotonin receptor 0.009 0.0952 0.0947
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.001 0.0007
Schistosoma mansoni hypothetical protein 0.009 0.0952 0.2339
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0024 0.0111 0.0142
Echinococcus multilocularis fmrfamide receptor 0.009 0.0952 0.0947
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.0418 0.0935
Entamoeba histolytica cysteine protease, putative 0.0031 0.0196 0.4054
Leishmania major cathepsin L-like protease 0.0052 0.0472 0.1044
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0098 0.1056 0.2595
Loa Loa (eye worm) hypothetical protein 0.0175 0.2048 0.4414
Loa Loa (eye worm) hypothetical protein 0.0024 0.0111 0.023
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.009 0.0952 0.1263
Onchocerca volvulus 0.0052 0.0472 0.1705
Brugia malayi Cytochrome P450 family protein 0.0037 0.0278 0.0622
Echinococcus multilocularis neuropeptides capa receptor 0.009 0.0952 0.0947
Loa Loa (eye worm) hypothetical protein 0.0043 0.0349 0.0742
Schistosoma mansoni rhodopsin-like orphan GPCR 0.009 0.0952 0.2339
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.001 0.0013
Brugia malayi calpain family protein 1 0.0043 0.0349 0.0779
Brugia malayi Histone deacetylase family protein 0.0166 0.193 0.4314
Onchocerca volvulus 0.0024 0.0111 0.0383
Entamoeba histolytica cysteine protease, putative 0.0031 0.0196 0.4054
Schistosoma mansoni histone deacetylase 4 5 0.0166 0.193 0.4754
Onchocerca volvulus 0.0052 0.0472 0.1705
Schistosoma mansoni histamine h1 receptor 0.009 0.0952 0.2339
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0152 0.1754 0.3779
Echinococcus granulosus serotonin receptor 0.009 0.0952 0.1263
Echinococcus granulosus Blood coagulation inhibitor Disintegrin 0.0112 0.1241 0.165
Schistosoma mansoni amine GPCR 0.009 0.0952 0.2339
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0019 0.0039 0.0076
Loa Loa (eye worm) hypothetical protein 0.009 0.0952 0.2046
Echinococcus multilocularis somatostatin receptor 0.009 0.0952 0.0947
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.0472 0.4425
Plasmodium vivax unspecified product 0.0031 0.0196 0.0989
Loa Loa (eye worm) cathepsin B 0.0098 0.1057 0.2272
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.009 0.0952 0.0947
Brugia malayi MH2 domain containing protein 0.0017 0.001 0.0023
Brugia malayi MH2 domain containing protein 0.0243 0.2926 0.654
Loa Loa (eye worm) hypothetical protein 0.009 0.0952 0.2046
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0016 0.0007 0.0011
Echinococcus multilocularis neuropeptide receptor 0.009 0.0952 0.0947
Onchocerca volvulus 0.0052 0.0472 0.1705
Echinococcus granulosus g protein coupled receptor 0.009 0.0952 0.1263
Loa Loa (eye worm) cytochrome P450 family protein 0.0037 0.0278 0.059
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0111 0.0552
Echinococcus granulosus cathepsin L 0.0031 0.0196 0.0254
Echinococcus multilocularis histone deacetylase 0.0166 0.193 0.1926
Echinococcus multilocularis adam 17 protease 0.0179 0.2099 0.2095
Brugia malayi Kringle domain containing protein 0.0035 0.0251 0.0561
Schistosoma mansoni opsin-like receptor 0.009 0.0952 0.2339
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.013 0.1466 0.3609
Loa Loa (eye worm) hypothetical protein 0.0024 0.0111 0.023
Plasmodium vivax histone deacetylase 2, putative 0.0166 0.193 1
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0024 0.0111 0.0106
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.009 0.0952 0.2046
Brugia malayi follicle stimulating hormone receptor 0.009 0.0952 0.2128
Loa Loa (eye worm) hypothetical protein 0.0024 0.0111 0.023
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0024 0.0111 0.023
Loa Loa (eye worm) melatonin receptor type 1A 0.009 0.0952 0.2046
Schistosoma mansoni biogenic amine receptor 0.009 0.0952 0.2339
Echinococcus multilocularis Solute carrier organic anion transporter family 0.0027 0.015 0.0145
Echinococcus granulosus cathepsin l cysteine peptidase 0.0052 0.0472 0.0623
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0052 0.0472 0.1044
Brugia malayi hypothetical protein 0.009 0.0952 0.2128
Echinococcus granulosus rhodopsin orphan GPCR 0.009 0.0952 0.1263
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.0472 0.4425
Echinococcus granulosus histone deacetylase 6 0.0166 0.193 0.2568
Trypanosoma cruzi cytochrome P450, putative 0.0037 0.0278 0.0611
Loa Loa (eye worm) TK/ROR protein kinase 0.0035 0.0251 0.0531
Echinococcus multilocularis mitogen activated protein kinase 11 0.0152 0.1754 0.175
Trypanosoma cruzi cysteine peptidase, putative 0.0052 0.0472 0.1044
Echinococcus multilocularis mitogen activated protein kinase 11 0.0152 0.1754 0.175
Entamoeba histolytica cysteine protease, putative 0.0031 0.0196 0.4054
Entamoeba histolytica cysteine protease, putative 0.0031 0.0196 0.4054
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0152 0.1754 0.3915
Brugia malayi Smad1 0.0017 0.001 0.0023
Brugia malayi sodium-independent organic anion transporter family protein 0.0027 0.015 0.0335
Leishmania major cathepsin L-like protease 0.0052 0.0472 0.1044
Trypanosoma cruzi MFS transporter, putative 0.0027 0.015 0.0324
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0016 0.0007 0.0016
Schistosoma mansoni cathepsin S (C01 family) 0.0016 0.0007 0.0005
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0024 0.0111 0.0249
Loa Loa (eye worm) TYRA-2 protein 0.009 0.0952 0.2046
Plasmodium vivax serine-repeat antigen (SERA) 0.0016 0.0007 0.0011
Schistosoma mansoni Smad4 0.0017 0.001 0.0013
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0052 0.0461 0.102
Brugia malayi cathepsin L-like cysteine proteinase 0.0016 0.0007 0.0016
Brugia malayi GnHR receptor homolog 0.009 0.0952 0.2128
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0031 0.0197 0.0475
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0472 0.4425
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0024 0.0111 0.023
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.009 0.0952 0.2339
Schistosoma mansoni myosin xvIII 0.009 0.0952 0.2339
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0052 0.0472 0.0467
Trypanosoma cruzi oligopeptidase b 0.0052 0.0461 0.102
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0019 0.0038 0.0085
Schistosoma mansoni neuropeptide f receptor 76f 0.009 0.0952 0.2339
Brugia malayi larval opioid receptor 0.009 0.0952 0.2128
Loa Loa (eye worm) hypothetical protein 0.0018 0.0027 0.0046
Loa Loa (eye worm) calpain family protein 1 0.0043 0.0349 0.0742
Echinococcus multilocularis smad 0.0017 0.001 0.0005
Loa Loa (eye worm) cysteine protease 0.0052 0.0472 0.1008
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.0472 0.4425
Echinococcus multilocularis neuropeptide Y receptor 0.009 0.0952 0.0947
Trypanosoma cruzi cysteine peptidase, putative 0.0052 0.0472 0.1044
Echinococcus multilocularis neuropeptide Y receptor 0.009 0.0952 0.0947
Schistosoma mansoni cathepsin C 0.0016 0.0007 0.0005
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0052 0.0472 0.1044
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0024 0.0111 0.0249
Schistosoma mansoni amine GPCR 0.009 0.0952 0.2339
Brugia malayi G protein-coupled receptor 0.009 0.0952 0.2128
Loa Loa (eye worm) hypothetical protein 0.009 0.0952 0.2046
Echinococcus granulosus cathepsin b 0.028 0.3402 0.4532
Loa Loa (eye worm) hypothetical protein 0.0024 0.0111 0.023
Echinococcus multilocularis cysteine protease 0.0052 0.0472 0.0467
Loa Loa (eye worm) cytochrome P450 family protein 0.008 0.0822 0.1765
Trypanosoma cruzi histone deacetylase, putative 0.0166 0.193 0.4308
Entamoeba histolytica cysteine protease, putative 0.0031 0.0196 0.4054
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0004
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0152 0.1754 0.3915
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.0472 0.4425
Echinococcus granulosus neuropeptide Y receptor 0.009 0.0952 0.1263
Echinococcus granulosus nAChR subunit 0.0024 0.0111 0.0142
Schistosoma mansoni hypothetical protein 0.0032 0.021 0.0507
Echinococcus granulosus subfamily M12B unassigned peptidase 0.0018 0.0027 0.0029
Schistosoma mansoni hypothetical protein 0.009 0.0952 0.2339
Entamoeba histolytica cysteine proteinase, putative 0.0031 0.0196 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0472 0.4425
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0024 0.0111 0.0106
Schistosoma mansoni nAChR subunit 0.0024 0.0111 0.0263
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0111 0.0542
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0019 0.0038 0.0085
Loa Loa (eye worm) hypothetical protein 0.009 0.0952 0.2046
Leishmania major cathepsin L-like protease 0.0052 0.0472 0.1044
Loa Loa (eye worm) hypothetical protein 0.0024 0.0111 0.023
Brugia malayi Dopamine receptor 0.009 0.0952 0.2128
Schistosoma mansoni follistatin 0.0019 0.0038 0.0081
Onchocerca volvulus 0.0098 0.1056 0.3848
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.009 0.0952 0.0947
Schistosoma mansoni hypothetical protein 0.0331 0.4054 1
Echinococcus multilocularis Smad4 0.0017 0.001 0.0005
Echinococcus granulosus agrin 0.0019 0.0038 0.0044
Echinococcus granulosus glycine receptor subunit alpha 1 0.0024 0.0111 0.0142
Giardia lamblia Cathepsin B precursor 0.0098 0.1057 1
Echinococcus granulosus mitogen activated protein kinase 14 0.0152 0.1754 0.2334
Echinococcus granulosus GPCR family 2 0.0032 0.021 0.0274
Trypanosoma cruzi cysteine peptidase, putative 0.0052 0.0472 0.1044
Entamoeba histolytica cysteine proteinase, putative 0.0052 0.0472 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0472 0.4425
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0418 0.102
Echinococcus granulosus glycine receptor subunit beta 0.0024 0.0111 0.0142
Loa Loa (eye worm) hypothetical protein 0.009 0.0952 0.2046
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0016 0.0007 0.0005
Echinococcus multilocularis rhodopsin orphan GPCR 0.009 0.0952 0.0947
Schistosoma mansoni hypothetical protein 0.0032 0.021 0.0507
Echinococcus granulosus tm gpcr rhodopsin 0.009 0.0952 0.1263
Brugia malayi hypothetical protein 0.009 0.0952 0.2128
Onchocerca volvulus Cathepsin L homolog 0.0052 0.0472 0.1705
Brugia malayi ORL1-like opioid receptor 0.009 0.0952 0.2128
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0472 0.4425
Toxoplasma gondii cytochrome p450 superfamily protein 0.0019 0.0039 0.0165
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0098 0.1057 0.2598
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0052 0.0461 0.102
Echinococcus multilocularis histone deacetylase 6 0.0166 0.193 0.1926
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0472 0.4425
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0024 0.0111 0.0249
Echinococcus granulosus peptide allatostatin:somatostatin 0.009 0.0952 0.1263
Loa Loa (eye worm) hypothetical protein 0.0024 0.0111 0.023
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0175 0.2048 0.7492
Onchocerca volvulus 0.009 0.0952 0.3468
Echinococcus multilocularis g-protein coupled receptor 0.009 0.0952 0.0947
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0045 0.0374 0.091
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0016 0.0007 0.0011
Echinococcus granulosus orexin receptor type 2 0.009 0.0952 0.1263
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0037 0.0278 0.5672
Onchocerca volvulus 0.0027 0.015 0.0523
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0004
Onchocerca volvulus 0.0052 0.0472 0.1705
Trypanosoma brucei cytochrome P450, putative 0.0037 0.0278 0.0611
Echinococcus multilocularis rhodopsin orphan GPCR 0.009 0.0952 0.0947
Leishmania major cytochrome p450-like protein 0.0037 0.0278 0.0611
Echinococcus granulosus glycine receptor subunit beta 0.0024 0.0111 0.0142
Echinococcus granulosus rhodopsin orphan GPCR 0.009 0.0952 0.1263
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.0472 0.4425
Echinococcus multilocularis Blood coagulation inhibitor, Disintegrin 0.0112 0.1241 0.1237
Schistosoma mansoni hypothetical protein 0.0019 0.0039 0.0084
Echinococcus multilocularis alpha 1A adrenergic receptor 0.009 0.0952 0.0947
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0111 0.0238
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0376 0.464 0.4637
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.009 0.0952 0.0947
Loa Loa (eye worm) sodium-independent organic anion transporter 0.0027 0.015 0.0313
Loa Loa (eye worm) hypothetical protein 0.0019 0.0038 0.0071
Schistosoma mansoni cathepsin F (C01 family) 0.0038 0.0283 0.0687
Brugia malayi calpain family protein 1 0.0043 0.0349 0.0779
Echinococcus granulosus rhodopsin orphan GPCR 0.009 0.0952 0.1263
Leishmania major cathepsin L-like protease 0.0052 0.0472 0.1044
Brugia malayi putative neuropeptide receptor NPR1 0.009 0.0952 0.2128
Trypanosoma brucei prolyl oligopeptidase, putative 0.0052 0.0461 0.102
Echinococcus multilocularis organic anion transporting polypeptide 30B 0.0027 0.015 0.0145
Onchocerca volvulus Cathepsin L homolog 0.0052 0.0472 0.1705
Onchocerca volvulus 0.0087 0.0915 0.333
Loa Loa (eye worm) hypothetical protein 0.0027 0.015 0.0313
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0024 0.0111 0.0249
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0024 0.0111 0.0142
Loa Loa (eye worm) hypothetical protein 0.009 0.0952 0.2046
Echinococcus multilocularis histone deacetylase 6 0.0166 0.193 0.1926
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0016 0.0007 0.0004
Onchocerca volvulus Putative organic anion transporter 0.0027 0.015 0.0523
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0098 0.1056 0.2595
Loa Loa (eye worm) hypothetical protein 0.009 0.0952 0.2046
Echinococcus multilocularis cathepsin L 0.0016 0.0007 0.0002
Loa Loa (eye worm) hypothetical protein 0.0019 0.0038 0.0071
Echinococcus granulosus histone deacetylase 7 0.0166 0.193 0.2568
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.009 0.0952 0.0947
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0052 0.0472 0.1044
Brugia malayi MH2 domain containing protein 0.0017 0.001 0.0023
Loa Loa (eye worm) hypothetical protein 0.0027 0.015 0.0313
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.0472 0.4425
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0472 0.4425
Brugia malayi prolyl oligopeptidase family protein 0.013 0.1466 0.3278
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0016 0.0007 0.0005
Schistosoma mansoni nAChR subunit 0.0024 0.0111 0.0263
Plasmodium vivax histone deacetylase, putative 0.0166 0.193 1
Brugia malayi hypothetical protein 0.0024 0.0111 0.0249
Loa Loa (eye worm) MH2 domain-containing protein 0.0243 0.2926 0.6309
Echinococcus multilocularis disintegrin and metalloproteinase 0.0018 0.0027 0.0021
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0472 0.4425
Onchocerca volvulus 0.0228 0.2732 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0111 0.023
Schistosoma mansoni opsin-like receptor 0.009 0.0952 0.2339
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0052 0.0472 0.4425
Toxoplasma gondii cathepsin CPL 0.0052 0.0472 0.2416
Echinococcus granulosus alpha 1A adrenergic receptor 0.009 0.0952 0.1263
Loa Loa (eye worm) hypothetical protein 0.028 0.3402 0.7338
Echinococcus granulosus biogenic amine 5HT receptor 0.009 0.0952 0.1263
Loa Loa (eye worm) ACC-1 protein 0.0024 0.0111 0.023
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0024 0.0111 0.023
Leishmania major cathepsin L-like protease 0.0052 0.0472 0.1044
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0016 0.0007 0.0005
Schistosoma mansoni rhodopsin-like orphan GPCR 0.009 0.0952 0.2339
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0019 0.0038 0.016
Echinococcus granulosus G protein coupled receptor 139 0.009 0.0952 0.1263
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0007 0.0016
Schistosoma mansoni rhodopsin-like orphan GPCR 0.009 0.0952 0.2339
Echinococcus granulosus smad 0.0017 0.001 0.0007
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0016 0.0007 0.0011
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0152 0.1754 0.3915
Brugia malayi Cation transporter family protein 0.0024 0.0111 0.0249
Echinococcus granulosus calpain A 0.0045 0.0374 0.0492
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0024 0.0111 0.0106
Onchocerca volvulus 0.009 0.0952 0.3468
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.0007 0.0004
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.009 0.0952 0.3468
Echinococcus granulosus rhodopsin orphan GPCR 0.009 0.0952 0.1263
Brugia malayi Cathepsin L-like precursor 0.0052 0.0472 0.1054
Echinococcus granulosus histone deacetylase 0.0166 0.193 0.2568
Loa Loa (eye worm) CYP4Cod1 0.0037 0.0278 0.059
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.009 0.0952 0.2339
Loa Loa (eye worm) kazal-type serine protease inhibitor domain-containing protein 0.0019 0.0038 0.0071
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0472 0.4425
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.009 0.0952 0.2339
Onchocerca volvulus 0.009 0.0952 0.3468
Loa Loa (eye worm) cytochrome P450 0.0019 0.0039 0.0073
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0052 0.0472 0.1044
Brugia malayi Serotonin/octopamine receptor family protein 7 0.009 0.0952 0.2128
Schistosoma mansoni hypothetical protein 0.0032 0.021 0.0507
Echinococcus granulosus adam 17 protease 0.0197 0.2328 0.31
Onchocerca volvulus Putative organic anion transporter 0.0027 0.015 0.0523
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0152 0.1754 0.3915
Echinococcus granulosus neuropeptide s receptor 0.009 0.0952 0.1263
Echinococcus multilocularis follistatin 0.0019 0.0038 0.0033
Echinococcus multilocularis 0.0019 0.0039 0.0034
Leishmania major cathepsin L-like protease 0.0052 0.0472 0.1044
Echinococcus granulosus neuropeptide receptor A26 0.009 0.0952 0.1263
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0024 0.0111 0.0249
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0052 0.0461 1
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.028 0.3402 0.8389
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0325 0.3977 0.9809
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0007 0.0016
Echinococcus multilocularis agrin 0.0019 0.0038 0.0033
Loa Loa (eye worm) hypothetical protein 0.009 0.0952 0.2046
Loa Loa (eye worm) neuropeptide F receptor 0.009 0.0952 0.2046
Loa Loa (eye worm) hypothetical protein 0.0098 0.1056 0.227
Loa Loa (eye worm) hypothetical protein 0.009 0.0952 0.2046
Leishmania major hypothetical protein, conserved 0.0024 0.0111 0.0238
Loa Loa (eye worm) hypothetical protein 0.0186 0.2187 0.4714
Echinococcus multilocularis g protein coupled receptor 0.009 0.0952 0.0947
Schistosoma mansoni cathepsin F (C01 family) 0.0052 0.0472 0.1152
Onchocerca volvulus 0.009 0.0952 0.3468
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.028 0.3402 0.8389
Echinococcus granulosus cathepsin L cysteine proteinase 0.0052 0.0472 0.0623
Loa Loa (eye worm) hypothetical protein 0.009 0.0952 0.2046
Schistosoma mansoni rhodopsin-like orphan GPCR 0.009 0.0952 0.2339
Echinococcus granulosus tachykinin peptides receptor 99D 0.0376 0.464 0.6184
Plasmodium falciparum cysteine repeat modular protein 1 0.0035 0.0251 0.1267
Brugia malayi Papain family cysteine protease containing protein 0.0031 0.0196 0.0437
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.009 0.0952 0.0947
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0024 0.0111 0.0106
Trypanosoma cruzi major cysteine proteinase, putative 0.0016 0.0007 0.0005
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0024 0.0111 0.023
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0016 0.0007 0.0005

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.02 uM Inhibition of p38alpha by immunosorbent based kinase assay ChEMBL. 22676210
IC50 (binding) = 170 uM Inhibition of p38alpha-dependent TNFalpha production in human whole blood ChEMBL. 22676210
Inhibition (binding) Inhibition of IGF1R at 10 uM ChEMBL. 22676210
Inhibition (binding) Inhibition of PRK1 at 10 uM ChEMBL. 22676210
Inhibition (binding) Inhibition of SRC at 10 uM ChEMBL. 22676210
Inhibition (binding) Inhibition of AXL at 10 uM ChEMBL. 22676210
Inhibition (binding) Inhibition of PLK1 at 10 uM ChEMBL. 22676210
Inhibition (binding) Inhibition of AKT1 at 10 uM ChEMBL. 22676210
Inhibition (binding) Inhibition of MET at 10 uM ChEMBL. 22676210
Inhibition (binding) Inhibition of TRKB at 10 uM ChEMBL. 22676210
Inhibition (binding) Inhibition of FAK at 10 uM ChEMBL. 22676210
Inhibition (binding) Inhibition of ARK5 at 10 uM ChEMBL. 22676210
Inhibition (binding) Inhibition of AuroraB at 10 uM ChEMBL. 22676210
Inhibition (binding) Inhibition of VEGFR2 at 10 uM ChEMBL. 22676210
Inhibition (binding) Inhibition of SAK at 10 uM ChEMBL. 22676210
Inhibition (binding) Inhibition of INSR at 10 uM ChEMBL. 22676210
Inhibition (binding) Inhibition of CK2alpha1 at 10 uM ChEMBL. 22676210

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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