Detailed information for compound 1721608

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 465.489 | Formula: C27H25F2NO4
  • H donors: 1 H acceptors: 1 LogP: 5.62 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(c(c1)F)Nc1ccc2c(c1)CCc1c(C2=O)ccc(c1)OC[C@@H]1COC(O1)(C)C
  • InChi: 1S/C27H25F2NO4/c1-27(2)33-15-21(34-27)14-32-20-7-9-23-17(12-20)4-3-16-11-19(6-8-22(16)26(23)31)30-25-10-5-18(28)13-24(25)29/h5-13,21,30H,3-4,14-15H2,1-2H3/t21-/m1/s1
  • InChiKey: BSJHGNQUVPKGIL-OAQYLSRUSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens mitogen-activated protein kinase 14 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase Get druggable targets OG5_128610 All targets in OG5_128610
Leishmania donovani mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Trypanosoma brucei gambiense mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Trypanosoma brucei mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Brugia malayi P38 map kinase family protein 2 Get druggable targets OG5_128610 All targets in OG5_128610
Leishmania infantum mitogen-activated protein kinase 3, putative,map kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Schistosoma japonicum ko:K04441 p38 MAP kinase, putative Get druggable targets OG5_128610 All targets in OG5_128610
Candida albicans MAP kinase involved in osmoregulation Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus multilocularis mitogen activated protein kinase 14 Get druggable targets OG5_128610 All targets in OG5_128610
Trypanosoma congolense mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Trypanosoma cruzi mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Candida albicans MAP kinase involved in osmoregulation Get druggable targets OG5_128610 All targets in OG5_128610
Leishmania mexicana mitogen-activated protein kinase 3, putative,map kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus multilocularis mitogen activated protein kinase 14 Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus granulosus mitogen activated protein kinase 14 Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus granulosus mitogen activated protein kinase 11 Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus multilocularis mitogen activated protein kinase 11 Get druggable targets OG5_128610 All targets in OG5_128610
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Trypanosoma cruzi mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus multilocularis mitogen activated protein kinase 11 Get druggable targets OG5_128610 All targets in OG5_128610
Leishmania braziliensis mitogen-activated protein kinase 3, putative,map kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 mitogen-activated protein kinase 14 360 aa 336 aa 33.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0111 0.0238
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0376 0.464 0.4637
Schistosoma mansoni hypothetical protein 0.0019 0.0039 0.0084
Echinococcus multilocularis alpha 1A adrenergic receptor 0.009 0.0952 0.0947
Loa Loa (eye worm) hypothetical protein 0.0019 0.0038 0.0071
Schistosoma mansoni cathepsin F (C01 family) 0.0038 0.0283 0.0687
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.009 0.0952 0.0947
Loa Loa (eye worm) sodium-independent organic anion transporter 0.0027 0.015 0.0313
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.0472 0.4425
Echinococcus multilocularis Blood coagulation inhibitor, Disintegrin 0.0112 0.1241 0.1237
Echinococcus multilocularis rhodopsin orphan GPCR 0.009 0.0952 0.0947
Trypanosoma brucei cytochrome P450, putative 0.0037 0.0278 0.0611
Echinococcus granulosus rhodopsin orphan GPCR 0.009 0.0952 0.1263
Leishmania major cytochrome p450-like protein 0.0037 0.0278 0.0611
Echinococcus granulosus glycine receptor subunit beta 0.0024 0.0111 0.0142
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0004
Onchocerca volvulus 0.0052 0.0472 0.1705
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0037 0.0278 0.5672
Echinococcus granulosus orexin receptor type 2 0.009 0.0952 0.1263
Onchocerca volvulus 0.0027 0.015 0.0523
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0045 0.0374 0.091
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0016 0.0007 0.0011
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0024 0.0111 0.0249
Echinococcus multilocularis histone deacetylase 6 0.0166 0.193 0.1926
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0472 0.4425
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0052 0.0461 0.102
Echinococcus granulosus peptide allatostatin:somatostatin 0.009 0.0952 0.1263
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0472 0.4425
Brugia malayi ORL1-like opioid receptor 0.009 0.0952 0.2128
Toxoplasma gondii cytochrome p450 superfamily protein 0.0019 0.0039 0.0165
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0098 0.1057 0.2598
Echinococcus multilocularis g-protein coupled receptor 0.009 0.0952 0.0947
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0175 0.2048 0.7492
Onchocerca volvulus 0.009 0.0952 0.3468
Loa Loa (eye worm) hypothetical protein 0.0024 0.0111 0.023
Echinococcus multilocularis rhodopsin orphan GPCR 0.009 0.0952 0.0947
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0016 0.0007 0.0005
Schistosoma mansoni hypothetical protein 0.0032 0.021 0.0507
Brugia malayi hypothetical protein 0.009 0.0952 0.2128
Onchocerca volvulus Cathepsin L homolog 0.0052 0.0472 0.1705
Echinococcus granulosus tm gpcr rhodopsin 0.009 0.0952 0.1263
Entamoeba histolytica cysteine proteinase, putative 0.0052 0.0472 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0472 0.4425
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0418 0.102
Trypanosoma cruzi cysteine peptidase, putative 0.0052 0.0472 0.1044
Echinococcus granulosus GPCR family 2 0.0032 0.021 0.0274
Loa Loa (eye worm) hypothetical protein 0.009 0.0952 0.2046
Echinococcus granulosus glycine receptor subunit beta 0.0024 0.0111 0.0142
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.009 0.0952 0.0947
Schistosoma mansoni hypothetical protein 0.0331 0.4054 1
Echinococcus multilocularis Smad4 0.0017 0.001 0.0005
Echinococcus granulosus agrin 0.0019 0.0038 0.0044
Echinococcus granulosus mitogen activated protein kinase 14 0.0152 0.1754 0.2334
Echinococcus granulosus glycine receptor subunit alpha 1 0.0024 0.0111 0.0142
Giardia lamblia Cathepsin B precursor 0.0098 0.1057 1
Brugia malayi Dopamine receptor 0.009 0.0952 0.2128
Loa Loa (eye worm) hypothetical protein 0.0024 0.0111 0.023
Onchocerca volvulus 0.0098 0.1056 0.3848
Schistosoma mansoni follistatin 0.0019 0.0038 0.0081
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0111 0.0542
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0019 0.0038 0.0085
Leishmania major cathepsin L-like protease 0.0052 0.0472 0.1044
Loa Loa (eye worm) hypothetical protein 0.009 0.0952 0.2046
Echinococcus granulosus subfamily M12B unassigned peptidase 0.0018 0.0027 0.0029
Entamoeba histolytica cysteine proteinase, putative 0.0031 0.0196 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0472 0.4425
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0024 0.0111 0.0106
Schistosoma mansoni nAChR subunit 0.0024 0.0111 0.0263
Schistosoma mansoni hypothetical protein 0.009 0.0952 0.2339
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0152 0.1754 0.3915
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0004
Echinococcus granulosus nAChR subunit 0.0024 0.0111 0.0142
Schistosoma mansoni hypothetical protein 0.0032 0.021 0.0507
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.0472 0.4425
Echinococcus granulosus neuropeptide Y receptor 0.009 0.0952 0.1263
Echinococcus multilocularis cysteine protease 0.0052 0.0472 0.0467
Loa Loa (eye worm) cytochrome P450 family protein 0.008 0.0822 0.1765
Echinococcus granulosus cathepsin b 0.028 0.3402 0.4532
Loa Loa (eye worm) hypothetical protein 0.0024 0.0111 0.023
Entamoeba histolytica cysteine protease, putative 0.0031 0.0196 0.4054
Trypanosoma cruzi histone deacetylase, putative 0.0166 0.193 0.4308
Echinococcus multilocularis neuropeptide Y receptor 0.009 0.0952 0.0947
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.0472 0.4425
Trypanosoma cruzi cysteine peptidase, putative 0.0052 0.0472 0.1044
Echinococcus multilocularis neuropeptide Y receptor 0.009 0.0952 0.0947
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0024 0.0111 0.0249
Schistosoma mansoni amine GPCR 0.009 0.0952 0.2339
Loa Loa (eye worm) hypothetical protein 0.009 0.0952 0.2046
Brugia malayi G protein-coupled receptor 0.009 0.0952 0.2128
Schistosoma mansoni cathepsin C 0.0016 0.0007 0.0005
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0052 0.0472 0.1044
Echinococcus granulosus cathepsin L cysteine proteinase 0.0052 0.0472 0.0623
Schistosoma mansoni rhodopsin-like orphan GPCR 0.009 0.0952 0.2339
Loa Loa (eye worm) hypothetical protein 0.009 0.0952 0.2046
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0024 0.0111 0.023
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.009 0.0952 0.0947
Trypanosoma cruzi major cysteine proteinase, putative 0.0016 0.0007 0.0005
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0024 0.0111 0.0106
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0016 0.0007 0.0005
Echinococcus granulosus tachykinin peptides receptor 99D 0.0376 0.464 0.6184
Brugia malayi Papain family cysteine protease containing protein 0.0031 0.0196 0.0437
Plasmodium falciparum cysteine repeat modular protein 1 0.0035 0.0251 0.1267
Loa Loa (eye worm) hypothetical protein 0.0186 0.2187 0.4714
Leishmania major hypothetical protein, conserved 0.0024 0.0111 0.0238
Echinococcus multilocularis g protein coupled receptor 0.009 0.0952 0.0947
Loa Loa (eye worm) hypothetical protein 0.0098 0.1056 0.227
Loa Loa (eye worm) hypothetical protein 0.009 0.0952 0.2046
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.028 0.3402 0.8389
Schistosoma mansoni cathepsin F (C01 family) 0.0052 0.0472 0.1152
Onchocerca volvulus 0.009 0.0952 0.3468
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0007 0.0016
Echinococcus multilocularis agrin 0.0019 0.0038 0.0033
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0325 0.3977 0.9809
Loa Loa (eye worm) hypothetical protein 0.009 0.0952 0.2046
Loa Loa (eye worm) neuropeptide F receptor 0.009 0.0952 0.2046
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.028 0.3402 0.8389
Echinococcus granulosus neuropeptide receptor A26 0.009 0.0952 0.1263
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0024 0.0111 0.0249
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0052 0.0461 1
Onchocerca volvulus Putative organic anion transporter 0.0027 0.015 0.0523
Echinococcus multilocularis 0.0019 0.0039 0.0034
Leishmania major cathepsin L-like protease 0.0052 0.0472 0.1044
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0152 0.1754 0.3915
Echinococcus granulosus neuropeptide s receptor 0.009 0.0952 0.1263
Echinococcus multilocularis follistatin 0.0019 0.0038 0.0033
Loa Loa (eye worm) kazal-type serine protease inhibitor domain-containing protein 0.0019 0.0038 0.0071
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0472 0.4425
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.009 0.0952 0.2339
Loa Loa (eye worm) CYP4Cod1 0.0037 0.0278 0.059
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.009 0.0952 0.2339
Brugia malayi Serotonin/octopamine receptor family protein 7 0.009 0.0952 0.2128
Schistosoma mansoni hypothetical protein 0.0032 0.021 0.0507
Echinococcus granulosus adam 17 protease 0.0197 0.2328 0.31
Onchocerca volvulus 0.009 0.0952 0.3468
Loa Loa (eye worm) cytochrome P450 0.0019 0.0039 0.0073
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0052 0.0472 0.1044
Echinococcus granulosus rhodopsin orphan GPCR 0.009 0.0952 0.1263
Echinococcus granulosus histone deacetylase 0.0166 0.193 0.2568
Brugia malayi Cathepsin L-like precursor 0.0052 0.0472 0.1054
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0152 0.1754 0.3915
Brugia malayi Cation transporter family protein 0.0024 0.0111 0.0249
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.009 0.0952 0.3468
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.0007 0.0004
Echinococcus granulosus calpain A 0.0045 0.0374 0.0492
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0024 0.0111 0.0106
Onchocerca volvulus 0.009 0.0952 0.3468
Echinococcus granulosus G protein coupled receptor 139 0.009 0.0952 0.1263
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0007 0.0016
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0016 0.0007 0.0005
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0019 0.0038 0.016
Schistosoma mansoni rhodopsin-like orphan GPCR 0.009 0.0952 0.2339
Echinococcus granulosus smad 0.0017 0.001 0.0007
Schistosoma mansoni rhodopsin-like orphan GPCR 0.009 0.0952 0.2339
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0016 0.0007 0.0011
Leishmania major cathepsin L-like protease 0.0052 0.0472 0.1044
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0024 0.0111 0.023
Toxoplasma gondii cathepsin CPL 0.0052 0.0472 0.2416
Echinococcus granulosus alpha 1A adrenergic receptor 0.009 0.0952 0.1263
Loa Loa (eye worm) ACC-1 protein 0.0024 0.0111 0.023
Loa Loa (eye worm) hypothetical protein 0.028 0.3402 0.7338
Echinococcus granulosus biogenic amine 5HT receptor 0.009 0.0952 0.1263
Onchocerca volvulus 0.0228 0.2732 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0472 0.4425
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0052 0.0472 0.4425
Loa Loa (eye worm) hypothetical protein 0.0024 0.0111 0.023
Schistosoma mansoni opsin-like receptor 0.009 0.0952 0.2339
Brugia malayi prolyl oligopeptidase family protein 0.013 0.1466 0.3278
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0472 0.4425
Brugia malayi hypothetical protein 0.0024 0.0111 0.0249
Echinococcus multilocularis disintegrin and metalloproteinase 0.0018 0.0027 0.0021
Loa Loa (eye worm) MH2 domain-containing protein 0.0243 0.2926 0.6309
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0016 0.0007 0.0005
Plasmodium vivax histone deacetylase, putative 0.0166 0.193 1
Schistosoma mansoni nAChR subunit 0.0024 0.0111 0.0263
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.009 0.0952 0.0947
Echinococcus multilocularis cathepsin L 0.0016 0.0007 0.0002
Loa Loa (eye worm) hypothetical protein 0.0019 0.0038 0.0071
Echinococcus granulosus histone deacetylase 7 0.0166 0.193 0.2568
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0052 0.0472 0.1044
Loa Loa (eye worm) hypothetical protein 0.0027 0.015 0.0313
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.0472 0.4425
Brugia malayi MH2 domain containing protein 0.0017 0.001 0.0023
Loa Loa (eye worm) hypothetical protein 0.0027 0.015 0.0313
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0024 0.0111 0.0249
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0024 0.0111 0.0142
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0016 0.0007 0.0004
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0098 0.1056 0.2595
Loa Loa (eye worm) hypothetical protein 0.009 0.0952 0.2046
Onchocerca volvulus Putative organic anion transporter 0.0027 0.015 0.0523
Loa Loa (eye worm) hypothetical protein 0.009 0.0952 0.2046
Echinococcus multilocularis histone deacetylase 6 0.0166 0.193 0.1926
Echinococcus granulosus rhodopsin orphan GPCR 0.009 0.0952 0.1263
Leishmania major cathepsin L-like protease 0.0052 0.0472 0.1044
Brugia malayi putative neuropeptide receptor NPR1 0.009 0.0952 0.2128
Brugia malayi calpain family protein 1 0.0043 0.0349 0.0779
Onchocerca volvulus 0.0087 0.0915 0.333
Trypanosoma brucei prolyl oligopeptidase, putative 0.0052 0.0461 0.102
Echinococcus multilocularis organic anion transporting polypeptide 30B 0.0027 0.015 0.0145
Onchocerca volvulus Cathepsin L homolog 0.0052 0.0472 0.1705
Brugia malayi G-protein coupled receptor 0.009 0.0952 0.2128
Loa Loa (eye worm) hypothetical protein 0.009 0.0952 0.2046
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0116 0.1291 1
Brugia malayi Dopamine receptor protein 1 0.009 0.0952 0.2128
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0016 0.0007 0.0011
Brugia malayi calpain 7 0.0016 0.0005 0.0011
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.021 0.0274
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0007 0.0016
Echinococcus granulosus histone deacetylase 6 0.0166 0.193 0.2568
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0363 0.4473 1
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0251 0.055
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0045 0.0374 0.0369
Brugia malayi Cytochrome P450 family protein 0.008 0.0822 0.1838
Leishmania major hypothetical protein, conserved 0.0035 0.0251 0.055
Echinococcus granulosus tm gpcr rhodopsin 0.009 0.0952 0.1263
Loa Loa (eye worm) hypothetical protein 0.009 0.0952 0.2046
Loa Loa (eye worm) hypothetical protein 0.0024 0.0111 0.023
Brugia malayi prostaglandin transporter 0.0027 0.015 0.0335
Loa Loa (eye worm) hypothetical protein 0.009 0.0952 0.2046
Brugia malayi cathepsin L-like precursor 0.0038 0.0283 0.0634
Brugia malayi cathepsin B-like cysteine proteinase 0.028 0.3402 0.7604
Leishmania major histone deacetylase, putative 0.0166 0.193 0.4308
Schistosoma mansoni cytochrome P450 0.0019 0.0039 0.0084
Loa Loa (eye worm) hypothetical protein 0.009 0.0952 0.2046
Brugia malayi Cathepsin L-like cysteine proteinase 0.0038 0.0283 0.0634
Brugia malayi sodium-independent organic anion transporter family protein 0.0027 0.015 0.0335
Loa Loa (eye worm) hypothetical protein 0.009 0.0952 0.2046
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0031 0.0196 0.1794
Brugia malayi Cytochrome P450 family protein 0.0037 0.0278 0.0622
Echinococcus granulosus glycine receptor subunit alpha 1 0.0024 0.0111 0.0142
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0111 0.0238
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0031 0.0196 0.047
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0031 0.0196 0.047
Onchocerca volvulus Neuropeptide F receptor homolog 0.009 0.0952 0.3468
Trypanosoma brucei prolyl endopeptidase 0.013 0.1466 0.327
Schistosoma mansoni rhodopsin-like orphan GPCR 0.009 0.0952 0.2339
Brugia malayi putative neuropeptide receptor 0.009 0.0952 0.2128
Entamoeba histolytica cysteine proteinase, putative 0.0031 0.0196 0.4054
Trypanosoma cruzi histone deacetylase, putative 0.0166 0.193 0.4308
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0052 0.0472 0.1044
Brugia malayi Calcitonin receptor-like protein seb-1 0.0102 0.1103 0.2467
Leishmania major cathepsin L-like protease 0.0052 0.0472 0.1044
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0052 0.0472 0.1044
Schistosoma mansoni opsin-like receptor 0.009 0.0952 0.2339
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0024 0.0111 0.0142
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0111 0.0542
Echinococcus multilocularis neuropeptide FF receptor 2 0.009 0.0952 0.0947
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0325 0.3977 0.5299
Echinococcus granulosus hypothetical protein 0.009 0.0952 0.1263
Schistosoma mansoni biogenic amine (dopamine) receptor 0.009 0.0952 0.2339
Brugia malayi cytochrome P450 0.0019 0.0039 0.0087
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.009 0.0952 0.2046
Plasmodium falciparum cysteine proteinase falcipain 3 0.0052 0.0472 0.2416
Echinococcus multilocularis mitogen activated protein kinase 14 0.0152 0.1754 0.175
Loa Loa (eye worm) hypothetical protein 0.0166 0.193 0.4158
Loa Loa (eye worm) hypothetical protein 0.0019 0.0038 0.0071
Schistosoma mansoni nAChR subunit 0.0024 0.0111 0.0263
Schistosoma mansoni neuropeptide receptor 0.009 0.0952 0.2339
Echinococcus multilocularis tissue type plasminogen activator 0.0035 0.0251 0.0246
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.021 0.0444
Onchocerca volvulus Putative nachr subunit 0.0024 0.0111 0.0383
Echinococcus multilocularis histone deacetylase 6 0.0166 0.193 0.1926
Echinococcus granulosus neuropeptides capa receptor 0.009 0.0952 0.1263
Echinococcus granulosus rhodopsin orphan GPCR 0.009 0.0952 0.1263
Brugia malayi sodium-independent organic anion transporter family protein 0.0027 0.015 0.0335
Loa Loa (eye worm) agrin synaptic family protein 0.0019 0.0038 0.0071
Echinococcus multilocularis orexin receptor type 2 0.009 0.0952 0.0947
Echinococcus granulosus sex peptide receptor 0.009 0.0952 0.1263
Echinococcus multilocularis glycine receptor subunit beta 0.0024 0.0111 0.0106
Onchocerca volvulus Cathepsin F homolog 0.0052 0.0472 0.1705
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0024 0.0111 0.0263
Brugia malayi Cathepsin L-like precursor 0.0052 0.0472 0.1054
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0024 0.0111 0.0249
Schistosoma mansoni hypothetical protein 0.009 0.0952 0.2339
Loa Loa (eye worm) hypothetical protein 0.0038 0.0283 0.0601
Loa Loa (eye worm) hypothetical protein 0.0024 0.0111 0.023
Brugia malayi cathepsin L precursor 0.0016 0.0007 0.0016
Loa Loa (eye worm) hypothetical protein 0.0027 0.015 0.0313
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0019 0.0038 0.0085
Leishmania major histone deacetylase, putative 0.0166 0.193 0.4308
Trypanosoma cruzi major cysteine proteinase, putative 0.0016 0.0007 0.0005
Loa Loa (eye worm) cytochrome P450 family protein 0.0037 0.0278 0.059
Brugia malayi Histone deacetylase family protein 0.0166 0.193 0.4314
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0019 0.0039 0.0076
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0018 0.0027 0.0053
Schistosoma mansoni hypothetical protein 0.0331 0.4054 1
Onchocerca volvulus Prolyl endopeptidase homolog 0.013 0.1466 0.5356
Onchocerca volvulus 0.0024 0.0111 0.0383
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.009 0.0952 0.1263
Brugia malayi P38 map kinase family protein 2 0.0152 0.1754 0.3922
Echinococcus granulosus allatostatin A receptor 0.0228 0.2732 0.3638
Brugia malayi hypothetical protein 0.009 0.0952 0.2128
Schistosoma mansoni cathepsin F (C01 family) 0.0052 0.0472 0.1152
Trypanosoma brucei C-8 sterol isomerase, putative 0.0363 0.4473 1
Echinococcus granulosus cathepsin l1 0.0038 0.0283 0.0371
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0052 0.0472 0.4425
Echinococcus multilocularis mitogen activated protein kinase 14 0.0152 0.1754 0.175
Loa Loa (eye worm) hypothetical protein 0.0166 0.193 0.4158
Onchocerca volvulus 0.009 0.0952 0.3468
Schistosoma mansoni biogenic amine receptor 0.009 0.0952 0.2339
Toxoplasma gondii prolyl endopeptidase 0.013 0.1466 0.7589
Trypanosoma brucei histone deacetylase 3 0.0166 0.193 0.4308
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0052 0.0472 0.1008
Echinococcus multilocularis calpain A 0.0045 0.0374 0.0369
Loa Loa (eye worm) hypothetical protein 0.009 0.0952 0.2046
Loa Loa (eye worm) hypothetical protein 0.0102 0.1103 0.2373
Plasmodium vivax unspecified product 0.0016 0.0007 0.0011
Brugia malayi Cathepsin L-like precursor 0.0038 0.0283 0.0634
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0019 0.0038 0.016
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.009 0.0952 0.2339
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0004
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0325 0.3977 0.3974
Onchocerca volvulus 0.0038 0.0283 0.1014
Loa Loa (eye worm) hypothetical protein 0.0019 0.0038 0.0071
Trypanosoma cruzi cysteine peptidase, putative 0.0052 0.0472 0.1044
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.009 0.0952 0.2339
Plasmodium falciparum histone deacetylase, putative 0.0166 0.193 1
Echinococcus granulosus g protein coupled receptor 0.009 0.0952 0.1263
Loa Loa (eye worm) hypothetical protein 0.0018 0.0027 0.0046
Echinococcus multilocularis smad 0.0017 0.001 0.0005
Loa Loa (eye worm) cysteine protease 0.0052 0.0472 0.1008
Loa Loa (eye worm) calpain family protein 1 0.0043 0.0349 0.0742
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.009 0.0952 0.2339
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0024 0.0111 0.023
Schistosoma mansoni myosin xvIII 0.009 0.0952 0.2339
Brugia malayi GnHR receptor homolog 0.009 0.0952 0.2128
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0472 0.4425
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0031 0.0197 0.0475
Brugia malayi larval opioid receptor 0.009 0.0952 0.2128
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0019 0.0038 0.0085
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0052 0.0472 0.0467
Trypanosoma cruzi oligopeptidase b 0.0052 0.0461 0.102
Schistosoma mansoni neuropeptide f receptor 76f 0.009 0.0952 0.2339
Schistosoma mansoni cathepsin S (C01 family) 0.0016 0.0007 0.0005
Plasmodium vivax serine-repeat antigen (SERA) 0.0016 0.0007 0.0011
Schistosoma mansoni Smad4 0.0017 0.001 0.0013
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0052 0.0461 0.102
Brugia malayi cathepsin L-like cysteine proteinase 0.0016 0.0007 0.0016
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0024 0.0111 0.0249
Loa Loa (eye worm) TYRA-2 protein 0.009 0.0952 0.2046
Brugia malayi Smad1 0.0017 0.001 0.0023
Entamoeba histolytica cysteine protease, putative 0.0031 0.0196 0.4054
Echinococcus multilocularis mitogen activated protein kinase 11 0.0152 0.1754 0.175
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0152 0.1754 0.3915
Entamoeba histolytica cysteine protease, putative 0.0031 0.0196 0.4054
Trypanosoma cruzi MFS transporter, putative 0.0027 0.015 0.0324
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0016 0.0007 0.0016
Brugia malayi sodium-independent organic anion transporter family protein 0.0027 0.015 0.0335
Leishmania major cathepsin L-like protease 0.0052 0.0472 0.1044
Echinococcus multilocularis mitogen activated protein kinase 11 0.0152 0.1754 0.175
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.0472 0.4425
Echinococcus granulosus histone deacetylase 6 0.0166 0.193 0.2568
Loa Loa (eye worm) TK/ROR protein kinase 0.0035 0.0251 0.0531
Trypanosoma cruzi cytochrome P450, putative 0.0037 0.0278 0.0611
Trypanosoma cruzi cysteine peptidase, putative 0.0052 0.0472 0.1044
Brugia malayi hypothetical protein 0.009 0.0952 0.2128
Echinococcus granulosus rhodopsin orphan GPCR 0.009 0.0952 0.1263
Echinococcus granulosus cathepsin l cysteine peptidase 0.0052 0.0472 0.0623
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0052 0.0472 0.1044
Schistosoma mansoni biogenic amine receptor 0.009 0.0952 0.2339
Loa Loa (eye worm) melatonin receptor type 1A 0.009 0.0952 0.2046
Echinococcus multilocularis Solute carrier organic anion transporter family 0.0027 0.015 0.0145
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.009 0.0952 0.2046
Brugia malayi follicle stimulating hormone receptor 0.009 0.0952 0.2128
Plasmodium vivax histone deacetylase 2, putative 0.0166 0.193 1
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0024 0.0111 0.0106
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0024 0.0111 0.023
Loa Loa (eye worm) hypothetical protein 0.0024 0.0111 0.023
Echinococcus multilocularis adam 17 protease 0.0179 0.2099 0.2095
Brugia malayi Kringle domain containing protein 0.0035 0.0251 0.0561
Echinococcus granulosus cathepsin L 0.0031 0.0196 0.0254
Echinococcus multilocularis histone deacetylase 0.0166 0.193 0.1926
Schistosoma mansoni opsin-like receptor 0.009 0.0952 0.2339
Loa Loa (eye worm) hypothetical protein 0.0024 0.0111 0.023
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.013 0.1466 0.3609
Onchocerca volvulus 0.0052 0.0472 0.1705
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0016 0.0007 0.0011
Brugia malayi MH2 domain containing protein 0.0243 0.2926 0.654
Loa Loa (eye worm) hypothetical protein 0.009 0.0952 0.2046
Echinococcus multilocularis neuropeptide receptor 0.009 0.0952 0.0947
Loa Loa (eye worm) cytochrome P450 family protein 0.0037 0.0278 0.059
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0111 0.0552
Echinococcus granulosus g protein coupled receptor 0.009 0.0952 0.1263
Echinococcus granulosus Blood coagulation inhibitor Disintegrin 0.0112 0.1241 0.165
Echinococcus granulosus serotonin receptor 0.009 0.0952 0.1263
Schistosoma mansoni amine GPCR 0.009 0.0952 0.2339
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0152 0.1754 0.3779
Schistosoma mansoni histamine h1 receptor 0.009 0.0952 0.2339
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.0472 0.4425
Brugia malayi MH2 domain containing protein 0.0017 0.001 0.0023
Loa Loa (eye worm) cathepsin B 0.0098 0.1057 0.2272
Plasmodium vivax unspecified product 0.0031 0.0196 0.0989
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.009 0.0952 0.0947
Loa Loa (eye worm) hypothetical protein 0.009 0.0952 0.2046
Echinococcus multilocularis somatostatin receptor 0.009 0.0952 0.0947
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0019 0.0039 0.0076
Brugia malayi calpain family protein 1 0.0043 0.0349 0.0779
Brugia malayi Histone deacetylase family protein 0.0166 0.193 0.4314
Entamoeba histolytica cysteine protease, putative 0.0031 0.0196 0.4054
Onchocerca volvulus 0.0024 0.0111 0.0383
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.001 0.0013
Onchocerca volvulus 0.0052 0.0472 0.1705
Schistosoma mansoni histone deacetylase 4 5 0.0166 0.193 0.4754
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.009 0.0952 0.1263
Onchocerca volvulus 0.0052 0.0472 0.1705
Loa Loa (eye worm) hypothetical protein 0.0175 0.2048 0.4414
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0098 0.1056 0.2595
Loa Loa (eye worm) hypothetical protein 0.0024 0.0111 0.023
Loa Loa (eye worm) hypothetical protein 0.0043 0.0349 0.0742
Schistosoma mansoni rhodopsin-like orphan GPCR 0.009 0.0952 0.2339
Brugia malayi Cytochrome P450 family protein 0.0037 0.0278 0.0622
Echinococcus multilocularis neuropeptides capa receptor 0.009 0.0952 0.0947
Leishmania major cathepsin L-like protease 0.0052 0.0472 0.1044
Entamoeba histolytica cysteine protease, putative 0.0031 0.0196 0.4054
Echinococcus multilocularis serotonin receptor 0.009 0.0952 0.0947
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.001 0.0007
Echinococcus multilocularis fmrfamide receptor 0.009 0.0952 0.0947
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.0418 0.0935
Schistosoma mansoni hypothetical protein 0.009 0.0952 0.2339
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0024 0.0111 0.0142
Onchocerca volvulus 0.0035 0.0251 0.0894
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0031 0.0196 0.1794
Echinococcus multilocularis fmrfamide receptor 0.009 0.0952 0.0947
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.0472 0.4425
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0472 0.4425
Onchocerca volvulus 0.0027 0.0141 0.049
Brugia malayi Disintegrin family protein 0.0018 0.0027 0.0059
Loa Loa (eye worm) G-protein coupled receptor 0.009 0.0952 0.2046
Brugia malayi hypothetical protein 0.009 0.0952 0.2128
Schistosoma mansoni growth hormone secretagogue receptor 0.009 0.0952 0.2339
Trypanosoma cruzi cysteine protease, putative 0.0031 0.0196 0.0426
Loa Loa (eye worm) hypothetical protein 0.0038 0.0283 0.0601
Brugia malayi Cathepsin L-like precursor 0.0038 0.0283 0.0634
Trypanosoma cruzi cysteine proteinase, putative 0.0031 0.0196 0.0426
Schistosoma mansoni organic anion transporter 0.0027 0.015 0.0357
Echinococcus multilocularis allatostatin A receptor 0.0228 0.2732 0.2728
Brugia malayi Cathepsin L-like precursor 0.0052 0.0472 0.1054
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0019 0.0038 0.016
Loa Loa (eye worm) hypothetical protein 0.0024 0.0111 0.023
Loa Loa (eye worm) ACC-1 protein 0.0024 0.0111 0.023
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0024 0.0111 0.0106
Echinococcus granulosus glycine receptor subunit alpha 1 0.0024 0.0111 0.0142
Loa Loa (eye worm) hypothetical protein 0.009 0.0952 0.2046
Brugia malayi gonadotropin-releasing hormone receptor 2 0.009 0.0952 0.2128
Onchocerca volvulus 0.009 0.0952 0.3468
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0472 0.4425
Echinococcus granulosus somatostatin receptor 0.009 0.0952 0.1263
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0019 0.0038 0.0085
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0024 0.0111 0.0249
Schistosoma mansoni nAChR subunit 0.0024 0.0111 0.0263
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.009 0.0952 0.1263
Echinococcus granulosus a disintegrin and metalloproteinase with 0.0084 0.0884 0.1173
Loa Loa (eye worm) hypothetical protein 0.0052 0.0472 0.1008
Giardia lamblia Cathepsin B precursor 0.0098 0.1057 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.0007 0.0004
Echinococcus granulosus organic anion transporting polypeptide 30B 0.0027 0.015 0.0193
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0004
Loa Loa (eye worm) hypothetical protein 0.0024 0.0111 0.023
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0019 0.0038 0.016
Loa Loa (eye worm) hypothetical protein 0.0032 0.021 0.0444
Loa Loa (eye worm) hypothetical protein 0.0024 0.0111 0.023
Loa Loa (eye worm) reprolysin 0.0018 0.0027 0.0046
Echinococcus granulosus 7TM GPCR rhodopsin 0.009 0.0952 0.1263
Onchocerca volvulus 0.0024 0.0111 0.0383
Toxoplasma gondii histone deacetylase HDAC1 0.0166 0.193 1
Brugia malayi secreted modular calcium-binding protein 1 0.0019 0.0038 0.0085
Brugia malayi hypothetical protein 0.009 0.0952 0.2128
Echinococcus multilocularis rhodopsin orphan GPCR 0.009 0.0952 0.0947
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0472 0.4425
Leishmania major oligopeptidase b 0.0052 0.0461 0.102
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0024 0.0111 0.0263
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0052 0.0472 0.1044
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.009 0.0952 0.2128
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0016 0.0007 0.0011
Echinococcus granulosus cathepsin l1 0.0052 0.0472 0.0623
Loa Loa (eye worm) LGC-31 protein 0.0024 0.0111 0.023
Schistosoma mansoni nAChR subunit 0.0024 0.0111 0.0263
Schistosoma mansoni adenoreceptor 0.009 0.0952 0.2339
Loa Loa (eye worm) hypothetical protein 0.009 0.0952 0.2046
Schistosoma mansoni biogenic amine (5HT) receptor 0.009 0.0952 0.2339
Echinococcus multilocularis cysteine protease 0.0052 0.0472 0.0467
Schistosoma mansoni neuropeptide F-like receptor 0.009 0.0952 0.2339
Loa Loa (eye worm) hypothetical protein 0.009 0.0952 0.2046
Brugia malayi RE15519p 0.009 0.0952 0.2128
Loa Loa (eye worm) hypothetical protein 0.009 0.0952 0.2046
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0004
Brugia malayi Protein kinase domain containing protein 0.0035 0.0251 0.0561
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0418 0.0551
Loa Loa (eye worm) hypothetical protein 0.0024 0.0111 0.023
Loa Loa (eye worm) hypothetical protein 0.0069 0.069 0.148
Entamoeba histolytica cysteine proteinase, putative 0.0052 0.0472 1
Trypanosoma cruzi cytochrome P450, putative 0.0037 0.0278 0.0611
Echinococcus granulosus rhodopsin orphan GPCR 0.009 0.0952 0.1263
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0052 0.0472 0.2416
Loa Loa (eye worm) hypothetical protein 0.009 0.0952 0.2046
Echinococcus multilocularis neuropeptide s receptor 0.009 0.0952 0.0947
Loa Loa (eye worm) ctsf protein 0.0052 0.0472 0.1008
Schistosoma mansoni nAChR subunit 0.0024 0.0111 0.0263
Schistosoma mansoni biogenic amine (5HT) receptor 0.009 0.0952 0.2339
Echinococcus granulosus tissue type plasminogen activator 0.0035 0.0251 0.0328
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0052 0.0461 0.3369
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.0472 0.4425
Brugia malayi hypothetical protein 0.009 0.0952 0.2128
Echinococcus multilocularis GPCR, family 2 0.0032 0.021 0.0205
Entamoeba histolytica cysteine protease, putative 0.0031 0.0196 0.4054
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.009 0.0952 0.0947
Brugia malayi Melatonin receptor type 1A 0.009 0.0952 0.2128
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0016 0.0007 0.0005
Schistosoma mansoni smad1 5 8 and 0.0017 0.001 0.0013
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0024 0.0111 0.0249
Echinococcus multilocularis adam 0.0031 0.0197 0.0192
Trypanosoma brucei histone deacetylase 4 0.0166 0.193 0.4308
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0052 0.0472 0.1044
Echinococcus granulosus geminin 0.0331 0.4054 0.5402
Loa Loa (eye worm) hypothetical protein 0.013 0.1466 0.3157
Echinococcus granulosus fmrfamide receptor 0.009 0.0952 0.1263
Onchocerca volvulus 0.009 0.0952 0.3468
Schistosoma mansoni neuropeptide receptor 0.009 0.0952 0.2339
Loa Loa (eye worm) hypothetical protein 0.0024 0.0111 0.023
Brugia malayi N-terminal motif family protein 0.0175 0.2048 0.4579
Brugia malayi cathepsin F-like cysteine proteinase 0.0016 0.0007 0.0016
Loa Loa (eye worm) hypothetical protein 0.0027 0.015 0.0313
Entamoeba histolytica cysteine protease, putative 0.0031 0.0196 0.4054
Loa Loa (eye worm) hypothetical protein 0.0098 0.1056 0.227
Onchocerca volvulus 0.009 0.0952 0.3468
Schistosoma mansoni agrin 0.0019 0.0038 0.0081
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.001 0.0005
Echinococcus multilocularis neuropeptides capa receptor 0.009 0.0952 0.0947
Echinococcus multilocularis cathepsin b 0.028 0.3402 0.3398
Echinococcus granulosus neuropeptides capa receptor 0.009 0.0952 0.1263
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0052 0.0472 0.1044
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0016 0.0007 0.0011
Echinococcus granulosus cathepsin L 0.0016 0.0007 0.0003
Loa Loa (eye worm) hypothetical protein 0.0376 0.4634 1
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0024 0.0111 0.0142
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0052 0.0472 0.2416
Plasmodium vivax serine-repeat antigen (SERA) 0.0016 0.0007 0.0011
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.001 0.0007
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0019 0.0039 0.0076
Trypanosoma cruzi histone deacetylase, putative 0.0166 0.193 0.4308
Echinococcus granulosus cathepsin b 0.028 0.3402 0.4532
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.013 0.1466 0.327
Brugia malayi G-protein coupled receptor 0.009 0.0952 0.2128
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0031 0.0196 0.047
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0052 0.0461 0.102
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0102 0.1103 0.2467
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.001 0.0005
Schistosoma mansoni smad1 5 8 and 0.0017 0.001 0.0013
Onchocerca volvulus 0.0024 0.0111 0.0383
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.001 0.0011
Echinococcus granulosus Solute carrier organic anion transporter family 0.0027 0.015 0.0193
Trypanosoma brucei oligopeptidase b 0.0052 0.0461 0.102
Loa Loa (eye worm) hypothetical protein 0.009 0.0952 0.2046
Toxoplasma gondii protease inhibitor PI2 0.0019 0.0038 0.016
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0024 0.0111 0.0249
Loa Loa (eye worm) hypothetical protein 0.009 0.0952 0.2046
Toxoplasma gondii transporter, major facilitator family protein 0.0027 0.015 0.0742
Echinococcus multilocularis dro:myosuppressin receptor 0.009 0.0952 0.0947
Loa Loa (eye worm) hypothetical protein 0.009 0.0952 0.2046
Schistosoma mansoni biogenic amine (dopamine) receptor 0.009 0.0952 0.2339
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.021 0.0205
Schistosoma mansoni organic anion transporter 0.0027 0.015 0.0357
Leishmania major cysteine peptidase A (CPA) 0.0052 0.0472 0.1044
Loa Loa (eye worm) hypothetical protein 0.0024 0.0111 0.023
Giardia lamblia Cathepsin B precursor 0.0098 0.1057 1
Echinococcus multilocularis nAChR subunit 0.0024 0.0111 0.0106
Echinococcus multilocularis rhodopsin orphan GPCR 0.009 0.0952 0.0947
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0052 0.0472 0.1008
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0045 0.0374 0.0492
Echinococcus granulosus cathepsin L cysteine protease 0.0031 0.0196 0.0254
Loa Loa (eye worm) hypothetical protein 0.0024 0.0111 0.023
Entamoeba histolytica cysteine proteinase 1, putative 0.0031 0.0196 0.4054
Brugia malayi SPARC precursor 0.0019 0.0038 0.0085
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.009 0.0952 0.0947
Loa Loa (eye worm) hypothetical protein 0.009 0.0952 0.2046
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.013 0.1466 0.3609
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.009 0.0952 0.0947
Brugia malayi hypothetical protein 0.009 0.0952 0.2128
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0035 0.0251 0.1277
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.0418 0.0892
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0043 0.0349 0.0848
Plasmodium falciparum histone deacetylase 2 0.0166 0.193 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0036 0.0068
Echinococcus granulosus biogenic amine 5HT receptor 0.009 0.0952 0.1263
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0052 0.0461 0.102
Brugia malayi Cytochrome P450 family protein 0.0019 0.0039 0.0087
Onchocerca volvulus 0.009 0.0952 0.3468
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0098 0.1057 0.2354
Onchocerca volvulus 0.0024 0.0111 0.0383
Loa Loa (eye worm) hypothetical protein 0.0027 0.015 0.0313
Leishmania major cytochrome p450-like protein 0.0019 0.0039 0.0076
Trypanosoma cruzi oligopeptidase b 0.0052 0.0461 0.102
Trypanosoma cruzi cysteine peptidase, putative 0.0031 0.0196 0.0426
Trypanosoma cruzi prolyl endopeptidase 0.013 0.1466 0.327
Brugia malayi AKH receptor 0.009 0.0952 0.2128
Onchocerca volvulus 0.0019 0.0038 0.0113
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0418 0.0551
Plasmodium vivax vivapain-2 0.0052 0.0472 0.2424
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0472 0.4425
Brugia malayi cathepsin Z-like cysteine proteinase 0.0016 0.0007 0.0016
Echinococcus multilocularis cathepsin L cysteine protease 0.0052 0.0472 0.0467
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.009 0.0952 0.2128
Brugia malayi Serotonin receptor 0.009 0.0952 0.2128
Entamoeba histolytica cysteine protease, putative 0.0031 0.0196 0.4054
Schistosoma mansoni neuropeptide F-like receptor 0.009 0.0952 0.2339
Trypanosoma cruzi cysteine proteinase, putative 0.0031 0.0196 0.0426
Onchocerca volvulus 0.009 0.0952 0.3468
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0418 0.102
Brugia malayi Papain family cysteine protease containing protein 0.0052 0.0472 0.1054
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0016 0.0007 0.0005
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0024 0.0111 0.0249
Echinococcus multilocularis expressed protein 0.0019 0.0038 0.0033
Echinococcus multilocularis sex peptide receptor 0.009 0.0952 0.0947
Entamoeba histolytica cysteine protease, putative 0.0031 0.0196 0.4054
Loa Loa (eye worm) hypothetical protein 0.009 0.0952 0.2046
Echinococcus multilocularis rhodopsin orphan GPCR 0.009 0.0952 0.0947
Entamoeba histolytica cysteine proteinase, putative 0.0031 0.0196 0.4054
Echinococcus multilocularis neuropeptide receptor 0.009 0.0952 0.0947
Brugia malayi Cathepsin L-like precursor 0.0052 0.0472 0.1054
Entamoeba histolytica cysteine protease, putative 0.0031 0.0196 0.4054
Brugia malayi neuropeptide F receptor 0.009 0.0952 0.2128
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0019 0.0039 0.0076
Brugia malayi hypothetical protein 0.009 0.0952 0.2128
Brugia malayi Papain family cysteine protease containing protein 0.0031 0.0196 0.0437
Loa Loa (eye worm) hypothetical protein 0.0035 0.0251 0.0531
Echinococcus multilocularis cathepsin L cysteine protease 0.0052 0.0472 0.0467
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.009 0.0952 0.2339
Brugia malayi Cation transporter family protein 0.0024 0.0111 0.0249
Schistosoma mansoni hypothetical protein 0.009 0.0952 0.2339
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0024 0.0111 0.0142
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0024 0.0111 0.0263
Brugia malayi Latrophilin receptor protein 2 0.0032 0.021 0.047
Schistosoma mansoni cathepsin B (C01 family) 0.0016 0.0007 0.0005
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0024 0.0111 0.0249
Schistosoma mansoni biogenic amine (dopamine) receptor 0.009 0.0952 0.2339
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0024 0.0111 0.0142
Onchocerca volvulus 0.0024 0.0111 0.0383
Plasmodium falciparum cysteine proteinase falcipain 1 0.0031 0.0196 0.0979
Onchocerca volvulus 0.009 0.0952 0.3468
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.028 0.3402 0.8389
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.021 0.0205
Loa Loa (eye worm) hypothetical protein 0.0032 0.0203 0.0428
Loa Loa (eye worm) hypothetical protein 0.009 0.0952 0.2046
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0031 0.0196 0.0426
Echinococcus granulosus dro:myosuppressin receptor 0.009 0.0952 0.1263
Entamoeba histolytica cysteine protease, putative 0.0031 0.0196 0.4054
Loa Loa (eye worm) hypothetical protein 0.009 0.0952 0.2046
Onchocerca volvulus 0.0027 0.015 0.0523
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.0018 0.0027 0.0021
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0111 0.0238
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0024 0.0111 0.0142
Entamoeba histolytica cysteine protease, putative 0.0031 0.0196 0.4054
Loa Loa (eye worm) hypothetical protein 0.0363 0.4473 0.9653
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.0472 0.4425
Echinococcus granulosus cytochrome P450 2K1 0.0019 0.0039 0.0045
Toxoplasma gondii kringle domain-containing protein 0.0035 0.0251 0.1267
Plasmodium vivax vivapain-3 0.0031 0.0196 0.0989
Schistosoma mansoni neuropeptide receptor 0.009 0.0952 0.2339
Echinococcus multilocularis neuropeptide receptor A26 0.009 0.0952 0.0947
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.009 0.0952 0.2128
Loa Loa (eye worm) neuropeptide F receptor 0.009 0.0952 0.2046
Loa Loa (eye worm) hypothetical protein 0.0027 0.015 0.0313
Schistosoma mansoni amine GPCR 0.009 0.0952 0.2339
Schistosoma mansoni rhodopsin-like orphan GPCR 0.009 0.0952 0.2339
Loa Loa (eye worm) hypothetical protein 0.009 0.0952 0.2046
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0024 0.0111 0.0263
Loa Loa (eye worm) hypothetical protein 0.009 0.0952 0.2046
Echinococcus granulosus neuropeptide Y receptor 0.009 0.0952 0.1263
Echinococcus multilocularis rhodopsin orphan GPCR 0.009 0.0952 0.0947
Brugia malayi hypothetical protein 0.0027 0.015 0.0335
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0098 0.1057 1
Echinococcus multilocularis G protein coupled receptor 139 0.009 0.0952 0.0947
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0016 0.0007 0.0011
Echinococcus multilocularis rhodopsin orphan GPCR 0.009 0.0952 0.0947
Onchocerca volvulus 0.0027 0.015 0.0523
Loa Loa (eye worm) hypothetical protein 0.009 0.0952 0.2046
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0472 0.4425
Echinococcus granulosus histone deacetylase 6 0.0166 0.193 0.2568
Schistosoma mansoni smad 0.0017 0.001 0.0013
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0024 0.0111 0.023
Loa Loa (eye worm) hypothetical protein 0.009 0.0952 0.2046
Schistosoma mansoni dihydroceramide desaturase 0.0018 0.0027 0.0053
Loa Loa (eye worm) hypothetical protein 0.009 0.0952 0.2046
Leishmania major C-8 sterol isomerase-like protein 0.0363 0.4473 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0141 0.0293
Schistosoma mansoni alpha-1 adrenergic receptor 0.009 0.0952 0.2339
Loa Loa (eye worm) transcription factor SMAD2 0.0243 0.2926 0.6309
Loa Loa (eye worm) hypothetical protein 0.0024 0.0111 0.023
Entamoeba histolytica cysteine protease, putative 0.0052 0.0472 1
Loa Loa (eye worm) calpain family protein 1 0.0032 0.0203 0.0428
Loa Loa (eye worm) hypothetical protein 0.0027 0.015 0.0313
Brugia malayi hypothetical protein 0.009 0.0952 0.2128
Echinococcus granulosus cysteine protease 0.0031 0.0196 0.0254
Brugia malayi Cathepsin L-like precursor 0.0052 0.0472 0.1054
Echinococcus granulosus adam 0.0031 0.0197 0.0256
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0363 0.4473 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.009 0.0952 0.0947
Onchocerca volvulus 0.009 0.0952 0.3468
Mycobacterium tuberculosis Probable peptidase 0.0052 0.0461 0.3369
Echinococcus granulosus mitogen activated protein kinase 11 0.0152 0.1754 0.2334
Onchocerca volvulus 0.0027 0.015 0.0523
Onchocerca volvulus 0.009 0.0952 0.3468
Onchocerca volvulus 0.0027 0.015 0.0523
Loa Loa (eye worm) hypothetical protein 0.009 0.0952 0.2046
Loa Loa (eye worm) hypothetical protein 0.009 0.0952 0.2046
Brugia malayi metalloprotease disintegrin 16 with thrombospondin type I motif 0.0084 0.0884 0.1976
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0045 0.0374 0.091
Schistosoma mansoni histone deacetylase hda2 0.0166 0.193 0.4754
Schistosoma mansoni smad1 5 8 and 0.0017 0.001 0.0013
Brugia malayi hypothetical protein 0.0027 0.015 0.0335
Plasmodium vivax vivapain-2 0.0052 0.0472 0.2424
Loa Loa (eye worm) hypothetical protein 0.0024 0.0111 0.023
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.009 0.0952 0.1263
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0016 0.0007 0.0005
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0024 0.0111 0.0106
Schistosoma mansoni nAChR subunit 0.0024 0.0111 0.0263
Loa Loa (eye worm) fibroinase 0.0052 0.0472 0.1008
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.069 0.1543
Echinococcus multilocularis histone deacetylase 7 0.0166 0.193 0.1926
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.009 0.0952 0.2046
Brugia malayi cathepsin Z-like cysteine proteinase 0.0016 0.0007 0.0016
Loa Loa (eye worm) hypothetical protein 0.009 0.0952 0.2046
Schistosoma mansoni hypothetical protein 0.0069 0.069 0.1692
Brugia malayi Trypsin family protein 0.0098 0.1056 0.236
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0016 0.0007 0.0011
Trypanosoma brucei cysteine peptidase C (CPC) 0.0098 0.1057 0.2354
Brugia malayi neuropeptide F receptor 0.009 0.0952 0.2128
Echinococcus multilocularis a disintegrin and metalloproteinase with 0.0084 0.0884 0.0879
Loa Loa (eye worm) hypothetical protein 0.009 0.0952 0.2046
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0052 0.0472 0.0467
Entamoeba histolytica cysteine proteinase, putative 0.0038 0.0283 0.5946
Echinococcus multilocularis g protein coupled receptor 0.009 0.0952 0.0947
Schistosoma mansoni biogenic amine receptor 0.009 0.0952 0.2339
Echinococcus granulosus g protein coupled receptor 0.009 0.0952 0.1263
Leishmania major cytochrome p450-like protein 0.0019 0.0039 0.0076
Schistosoma mansoni neuropeptide receptor 0.009 0.0952 0.2339
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0016 0.0007 0.0011
Schistosoma mansoni hypothetical protein 0.0035 0.0251 0.0607
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.028 0.3402 0.7602
Onchocerca volvulus 0.0052 0.0472 0.1705
Brugia malayi Tachykinin-like peptides receptor 99D 0.009 0.0952 0.2128
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0024 0.0111 0.0263
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0228 0.2732 0.6734
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0038 0.0283 0.0623
Echinococcus multilocularis G-protein coupled receptor, putative 0.009 0.0952 0.0947
Brugia malayi Serotonin receptor 0.009 0.0952 0.2128
Loa Loa (eye worm) G-protein coupled receptor 0.009 0.0952 0.2046
Brugia malayi hypothetical protein 0.0031 0.0197 0.0441
Loa Loa (eye worm) Smad1 0.0017 0.001 0.0011
Echinococcus granulosus follistatin 0.0019 0.0038 0.0044
Onchocerca volvulus 0.0052 0.0472 0.1705
Brugia malayi excitatory GABA receptor EXP-1A 0.0024 0.0111 0.0249
Loa Loa (eye worm) hypothetical protein 0.0024 0.0111 0.023
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0052 0.0472 0.1044
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0098 0.1057 0.2354
Echinococcus multilocularis g protein coupled receptor 0.009 0.0952 0.0947
Echinococcus granulosus neuropeptide receptor 0.009 0.0952 0.1263
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.021 0.0274
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.009 0.0952 0.2339
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0418 0.102
Onchocerca volvulus 0.009 0.0952 0.3468
Brugia malayi fibroinase precursor 0.0016 0.0007 0.0016
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.009 0.0952 0.2339
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0024 0.0111 0.0263
Schistosoma mansoni rhodopsin-like orphan GPCR 0.009 0.0952 0.2339
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0024 0.0111 0.0106
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0418 0.0413
Brugia malayi Cathepsin L-like precursor 0.0052 0.0472 0.1054
Loa Loa (eye worm) hypothetical protein 0.009 0.0952 0.2046
Loa Loa (eye worm) hypothetical protein 0.009 0.0952 0.2046
Echinococcus granulosus 7tm_1 domain containing protein 0.009 0.0952 0.1263
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0024 0.0111 0.0106
Echinococcus multilocularis calpain family protein 1, d 0.0032 0.0203 0.0198
Loa Loa (eye worm) hypothetical protein 0.009 0.0952 0.2046
Trypanosoma cruzi cruzipain precursor, putative 0.0052 0.0472 0.1044
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0024 0.0111 0.0249
Brugia malayi Cation transporter family protein 0.0024 0.0111 0.0249
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0016 0.0007 0.0005
Echinococcus granulosus rhodopsin orphan GPCR 0.009 0.0952 0.1263
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0031 0.0196 0.0426
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0598 0.75 0.7498
Loa Loa (eye worm) hypothetical protein 0.0038 0.0283 0.0601
Brugia malayi hypothetical protein 0.009 0.0952 0.2128
Echinococcus granulosus tm gpcr rhodopsin 0.0598 0.75 1
Brugia malayi Dopamine receptor protein 2 0.009 0.0952 0.2128
Entamoeba histolytica cysteine protease, putative 0.0031 0.0196 0.4054
Echinococcus granulosus Smad4 0.0017 0.001 0.0007
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.001 0.0011
Echinococcus granulosus g-protein coupled receptor 0.009 0.0952 0.1263
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.028 0.3402 0.8389
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0004
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0418 0.0413
Schistosoma mansoni rhodopsin-like orphan GPCR 0.009 0.0952 0.2339
Plasmodium vivax vivapain-1 0.0031 0.0196 0.0989
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0024 0.0111 0.0249
Brugia malayi MH1 domain containing protein 0.0017 0.001 0.0023
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0024 0.0111 0.0249
Loa Loa (eye worm) hypothetical protein 0.009 0.0952 0.2046
Loa Loa (eye worm) hypothetical protein 0.0038 0.0286 0.0607
Schistosoma mansoni rhodopsin-like orphan GPCR 0.009 0.0952 0.2339
Entamoeba histolytica cysteine proteinase 2 0.0031 0.0196 0.4054
Echinococcus multilocularis cathepsin b 0.028 0.3402 0.3398
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0024 0.0111 0.0249
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0024 0.0111 0.0249
Loa Loa (eye worm) histone deacetylase 0.0166 0.193 0.4158
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0102 0.1103 0.2373
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0024 0.0111 0.0142
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0024 0.0111 0.0106
Trypanosoma brucei histone deacetylase, putative 0.0166 0.193 0.4308
Echinococcus multilocularis prolyl endopeptidase 0.013 0.1466 0.1462
Loa Loa (eye worm) histone deacetylase 7A 0.0166 0.193 0.4158
Onchocerca volvulus Putative organic anion transporter 0.0027 0.015 0.0523
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0016 0.0007 0.0005
Loa Loa (eye worm) hypothetical protein 0.009 0.0952 0.2046
Schistosoma mansoni ADAM17 peptidase (M12 family) 0.0179 0.2099 0.5172
Echinococcus multilocularis rhodopsin orphan GPCR 0.009 0.0952 0.0947
Echinococcus granulosus disintegrin and metalloproteinase 0.0018 0.0027 0.0029
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0024 0.0111 0.023
Schistosoma mansoni hypothetical protein 0.0032 0.021 0.0507
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0019 0.0039 0.0076
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.009 0.0952 0.0947
Echinococcus granulosus neuropeptide receptor 0.009 0.0952 0.1263
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.009 0.0952 0.2046
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.021 0.047
Brugia malayi G protein-coupled receptor F59B2.13 0.009 0.0952 0.2128
Onchocerca volvulus 0.009 0.0952 0.3468
Echinococcus multilocularis serotonin receptor 0.009 0.0952 0.0947
Schistosoma mansoni histone deacetylase 4 5 0.0166 0.193 0.4754
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0283 0.2631
Leishmania major cathepsin L-like protease 0.0052 0.0472 0.1044
Brugia malayi MH1 domain containing protein 0.0017 0.001 0.0023
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0018 0.0027 0.0053
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0472 0.4425
Schistosoma mansoni amine GPCR 0.009 0.0952 0.2339
Echinococcus multilocularis cathepsin L 0.0031 0.0196 0.019
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0052 0.0461 1
Echinococcus multilocularis geminin 0.0331 0.4054 0.4051
Loa Loa (eye worm) hypothetical protein 0.0228 0.2732 0.589
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0052 0.0472 0.1044
Toxoplasma gondii cathepsin B 0.0098 0.1057 0.546
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0283 0.2631
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0016 0.0007 0.0011
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0031 0.0196 0.0426
Onchocerca volvulus 0.009 0.0952 0.3468
Schistosoma mansoni ADAMTS5 peptidase (M12 family) 0.0084 0.0884 0.2171
Loa Loa (eye worm) hypothetical protein 0.0024 0.0111 0.023
Echinococcus granulosus neuropeptide FF receptor 2 0.009 0.0952 0.1263
Onchocerca volvulus 0.0052 0.0472 0.1705
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0024 0.0111 0.0106
Loa Loa (eye worm) hypothetical protein 0.009 0.0952 0.2046
Schistosoma mansoni amine GPCR 0.009 0.0952 0.2339
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0111 0.0542
Loa Loa (eye worm) hypothetical protein 0.009 0.0952 0.2046
Echinococcus multilocularis glycine receptor subunit beta 0.0024 0.0111 0.0106
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.009 0.0952 0.1263
Brugia malayi sulfakinin receptor protein 0.009 0.0952 0.2128
Entamoeba histolytica cysteine proteinase, putative 0.0031 0.0196 0.4054
Echinococcus granulosus prolyl endopeptidase 0.013 0.1466 0.195
Loa Loa (eye worm) follicle stimulating hormone receptor 0.009 0.0952 0.2046

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.36 uM Inhibition of p38alpha by immunosorbent based kinase assay ChEMBL. 22676210
IC50 (binding) = 123 uM Inhibition of p38alpha-dependent TNFalpha production in human whole blood ChEMBL. 22676210
Inhibition (binding) Inhibition of PLK1 at 10 uM ChEMBL. 22676210
Inhibition (binding) Inhibition of AuroraB at 10 uM ChEMBL. 22676210
Inhibition (binding) Inhibition of ARK5 at 10 uM ChEMBL. 22676210
Inhibition (binding) Inhibition of SAK at 10 uM ChEMBL. 22676210
Inhibition (binding) Inhibition of MET at 10 uM ChEMBL. 22676210
Inhibition (binding) Inhibition of TRKB at 10 uM ChEMBL. 22676210
Inhibition (binding) Inhibition of AKT1 at 10 uM ChEMBL. 22676210
Inhibition (binding) Inhibition of SRC at 10 uM ChEMBL. 22676210
Inhibition (binding) Inhibition of CK2alpha1 at 10 uM ChEMBL. 22676210

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.