Detailed information for compound 172245

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 302.371 | Formula: C16H22N4O2
  • H donors: 2 H acceptors: 2 LogP: 1.86 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc2nc(cnc2cc1OC)NC1CCCC(C1)N
  • InChi: 1S/C16H22N4O2/c1-21-14-7-12-13(8-15(14)22-2)20-16(9-18-12)19-11-5-3-4-10(17)6-11/h7-11H,3-6,17H2,1-2H3,(H,19,20)
  • InChiKey: VCHKFHNYXXARNR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0009 0.0044 0.0026
Loa Loa (eye worm) hypothetical protein 0.0016 0.0111 0.0111
Leishmania major hypothetical protein, conserved 0.0403 0.3537 1
Trypanosoma cruzi Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.0021 0.015 0.0376
Giardia lamblia Protein 21.1 0.0021 0.015 1
Loa Loa (eye worm) hypothetical protein 0.0005 0.001 0.001
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0021 0.015 0.0376
Trichomonas vaginalis ankyrin 2,3/unc44, putative 0.0021 0.015 0.0136
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0016 0.0111 0.0094
Echinococcus multilocularis expressed protein 0.0007 0.0028 0.0011
Echinococcus multilocularis Niemann Pick C1 protein 0.0079 0.0666 0.065
Leishmania major hypothetical protein, conserved 0.0021 0.015 0.0376
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0016 0.0111 0.0111
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.015 0.0136
Entamoeba histolytica hypothetical protein 0.0029 0.0223 0.3171
Brugia malayi Patched related family protein 10 0.0005 0.001 0.001
Echinococcus granulosus nuclear receptor nhr 48 0.0008 0.0036 0.0018
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0021 0.015 0.0376
Echinococcus granulosus expressed protein 0.0007 0.0028 0.0011
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.1133 1 1
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0008 0.0036 0.0018
Trypanosoma brucei predicted zinc finger protein 0.0021 0.015 0.0376
Brugia malayi AMP-binding enzyme family protein 0.0006 0.0017 0.0017
Brugia malayi isocitrate dehydrogenase 0.0013 0.008 0.008
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0021 0.015 0.0376
Mycobacterium ulcerans hypothetical protein 0.0019 0.0136 0.3115
Brugia malayi RNA recognition motif domain containing protein 0.0051 0.0417 0.0417
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0016 0.0111 0.0094
Brugia malayi YY1-associated factor 2 0.0403 0.3537 0.3537
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0016 0.0111 0.0111
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0013 0.008 0.0063
Schistosoma mansoni RNA binding protein 0.0403 0.3537 0.3525
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0021 0.015 0.0376
Entamoeba histolytica zinc finger domain containing protein 0.0021 0.015 0.2038
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0031 0.0014
Loa Loa (eye worm) hypothetical protein 0.0005 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0005 0.001 0.001
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0049 0.04 0.0383
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0006 0.0017 0.0177
Trichomonas vaginalis ubiquitin-protein ligase BRE1, putative 0.0021 0.015 0.0136
Entamoeba histolytica hypothetical protein 0.0021 0.015 0.2038
Brugia malayi AMP-binding enzyme family protein 0.0019 0.0136 0.0136
Onchocerca volvulus 0.0403 0.3537 0.353
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.015 0.0136
Loa Loa (eye worm) hypothetical protein 0.0005 0.001 0.001
Brugia malayi hypothetical protein 0.0021 0.015 0.015
Schistosoma mansoni Smad4 0.0007 0.0026 0.0008
Schistosoma mansoni patched 1 0.0034 0.0268 0.0251
Plasmodium vivax acetyl-CoA synthetase, putative 0.0006 0.0017 0.0007
Echinococcus multilocularis E3 ubiquitin protein ligase LRSAM1 0.0021 0.015 0.0132
Leishmania major hypothetical protein, conserved 0.0021 0.015 0.0376
Trichomonas vaginalis ankyrin, putative 0.0021 0.015 0.0136
Brugia malayi Patched family protein 0.0005 0.001 0.001
Brugia malayi Patched protein homolog 1 0.0005 0.001 0.001
Onchocerca volvulus 0.0403 0.3537 0.353
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0016 0.0111 0.0111
Schistosoma mansoni hypothetical protein 0.1133 1 1
Onchocerca volvulus 0.1133 1 1
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0021 0.015 0.0376
Chlamydia trachomatis DNA topoisomerase I 0.1133 1 1
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0008 0.0036 0.0018
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0026 0.0203 1
Loa Loa (eye worm) TAR-binding protein 0.0051 0.0417 0.0417
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0016 0.0111 0.0111
Echinococcus granulosus E3 ubiquitin protein ligase MYLIP 0.0021 0.015 0.0132
Loa Loa (eye worm) hypothetical protein 0.0189 0.1645 0.1645
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.015 0.0376
Loa Loa (eye worm) hypothetical protein 0.0021 0.015 0.015
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0014 0.0094 0.2
Brugia malayi Patched family protein 0.0005 0.001 0.001
Brugia malayi Smad1 0.0007 0.0026 0.0026
Onchocerca volvulus 0.004 0.0319 0.0309
Brugia malayi hypothetical protein 0.0021 0.015 0.015
Schistosoma mansoni RAR-like nuclear receptor 0.0016 0.0111 0.0094
Schistosoma mansoni zinc finger protein 0.0021 0.015 0.0132
Giardia lamblia Protein 21.1 0.0021 0.015 1
Echinococcus multilocularis ring finger protein 170 0.0021 0.015 0.0132
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0403 0.3537 0.3537
Loa Loa (eye worm) hypothetical protein 0.0021 0.015 0.015
Onchocerca volvulus 0.0021 0.015 0.0139
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0019 0.0134 0.3055
Schistosoma mansoni smad1 5 8 and 0.0007 0.0026 0.0008
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0019 0.0136 0.6416
Loa Loa (eye worm) hypothetical protein 0.0016 0.0111 0.0111
Onchocerca volvulus 0.0023 0.0172 0.0161
Loa Loa (eye worm) hypothetical protein 0.0005 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0021 0.015 0.015
Schistosoma mansoni apoferritin-2 0.0007 0.0028 0.0011
Loa Loa (eye worm) hypothetical protein 0.0008 0.0036 0.0036
Schistosoma mansoni ring finger protein 151 0.0021 0.015 0.0132
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.015 0.0376
Trypanosoma brucei hypothetical protein, conserved 0.0019 0.0134 0.0331
Echinococcus granulosus FTZ F1 alpha 0.0016 0.0111 0.0094
Loa Loa (eye worm) hypothetical protein 0.0005 0.001 0.001
Toxoplasma gondii Bardet-Biedl syndrome 5, putative 0.0021 0.015 0.0139
Trypanosoma brucei SNF2 family N-terminal domain/Ring finger domain containing protein, putative 0.0021 0.015 0.0376
Loa Loa (eye worm) hypothetical protein 0.0016 0.0111 0.0111
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0006 0.0017 0.0177
Brugia malayi Niemann-Pick C1 protein precursor 0.0079 0.0666 0.0666
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0006 0.0017 0.0007
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0021 0.015 0.0376
Brugia malayi Patched family protein 0.0005 0.001 0.001
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0016 0.0111 0.0111
Brugia malayi Patched family protein 0.0005 0.001 0.001
Plasmodium falciparum E3 ubiquitin-protein ligase, putative 0.0021 0.015 0.0139
Loa Loa (eye worm) hypothetical protein 0.0009 0.0044 0.0044
Trypanosoma cruzi WLM domain containing protein, putative 0.0403 0.3537 1
Echinococcus granulosus RING finger and transmembrane domain containing protein 0.0021 0.015 0.0132
Schistosoma mansoni tar DNA-binding protein 0.0051 0.0417 0.04
Giardia lamblia Protein 21.1 0.0021 0.015 1
Echinococcus granulosus sterol regulatory element binding protein 0.0034 0.0268 0.0251
Onchocerca volvulus 0.0067 0.0558 0.0548
Loa Loa (eye worm) histone methyltransferase 0.0007 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0005 0.001 0.001
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0007 0.0028 0.0454
Brugia malayi hypothetical protein 0.0021 0.015 0.015
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0019 0.0136 0.3115
Echinococcus multilocularis tar DNA binding protein 0.0051 0.0417 0.04
Schistosoma mansoni nuclear receptor nhr-48 0.0008 0.0036 0.0018
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0009 0.0044 0.0044
Trypanosoma cruzi hypothetical protein 0.0021 0.015 0.0376
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.015 0.0136
Loa Loa (eye worm) MH2 domain-containing protein 0.0096 0.0815 0.0815
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0006 0.0017 0.0177
Giardia lamblia Protein 21.1 0.0021 0.015 1
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0013 0.008 0.0178
Brugia malayi nuclear hormone receptor 0.0008 0.0036 0.0036
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0021 0.015 0.0376
Schistosoma mansoni hypothetical protein 0.0033 0.0257 0.024
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0008 0.0036 0.0018
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger) containing protein, putative 0.0021 0.015 0.0376
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0006 0.0017 0.0177
Toxoplasma gondii isocitrate dehydrogenase 0.0013 0.008 0.007
Echinococcus multilocularis sterol regulatory element binding protein 0.0034 0.0268 0.0251
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0016 0.0111 0.0094
Echinococcus granulosus SWI:SNF matrix associated 0.1133 1 1
Trichomonas vaginalis antibiotic synthetase, putative 0.0006 0.0017 0.0003
Trichomonas vaginalis antibiotic synthetase, putative 0.0006 0.0017 0.0003
Echinococcus multilocularis SWI:SNF matrix associated 0.1133 1 1
Schistosoma mansoni peter pan-related 0.0021 0.015 0.0132
Loa Loa (eye worm) inositol-1 0.003 0.023 0.023
Trichomonas vaginalis ubiquitin-protein ligase BRE1, putative 0.0021 0.015 0.0136
Echinococcus multilocularis Nuclear pore complex protein Nup153 0.0403 0.3537 0.3525
Brugia malayi MH2 domain containing protein 0.0007 0.0026 0.0026
Schistosoma mansoni hypothetical protein 0.0039 0.031 0.0293
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.015 0.0136
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0021 0.015 0.0376
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.003 0.023 0.5576
Brugia malayi Patched family protein 0.0005 0.001 0.001
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.015 0.0136
Leishmania major hypothetical protein, conserved 0.0021 0.015 0.0376
Brugia malayi hypothetical protein 0.0008 0.0036 0.0036
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0016 0.0111 0.0111
Schistosoma mansoni smad 0.0007 0.0026 0.0008
Echinococcus multilocularis thyroid hormone receptor alpha 0.0016 0.0111 0.0094
Schistosoma mansoni coup transcription factor 0.0016 0.0111 0.0094
Trichomonas vaginalis ankyrin, putative 0.0021 0.015 0.0136
Brugia malayi Patched family protein 0.0005 0.001 0.001
Schistosoma mansoni brg-1 associated factor 0.1133 1 1
Brugia malayi B-box zinc finger family protein 0.0021 0.015 0.015
Schistosoma mansoni ferritin 0.0007 0.0028 0.0011
Onchocerca volvulus 0.0008 0.0036 0.0025
Giardia lamblia Protein 21.1 0.0021 0.015 1
Brugia malayi hypothetical protein 0.0005 0.001 0.001
Brugia malayi Patched family protein 0.0005 0.001 0.001
Plasmodium vivax E3 ubiquitin-protein ligase, putative 0.0021 0.015 0.0139
Echinococcus multilocularis Smad4 0.0007 0.0026 0.0008
Toxoplasma gondii helicase, putative 0.0021 0.015 0.0139
Echinococcus granulosus Upstream activation factor subunit UAF30 0.1133 1 1
Brugia malayi hypothetical protein 0.0005 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.004 0.0319 0.0319
Loa Loa (eye worm) nuclear hormone receptor 0.0008 0.0036 0.0036
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0013 0.008 0.0063
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0016 0.0111 0.0094
Toxoplasma gondii aldehyde dehydrogenase 0.0049 0.0399 0.0389
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0016 0.0111 0.0094
Trypanosoma brucei mitochondrial RNA binding complex 1 subunit 0.0403 0.3537 1
Echinococcus granulosus survival motor neuron protein 1 0.0189 0.1645 0.163
Brugia malayi Patched family protein 0.0005 0.001 0.001
Schistosoma mansoni hypothetical protein 0.0403 0.3537 0.3525
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0019 0.0134 0.0124
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.015 0.0136
Onchocerca volvulus 0.0016 0.0111 0.0101
Echinococcus granulosus Nuclear hormone receptor HR96 0.0008 0.0036 0.0018
Schistosoma mansoni hypothetical protein 0.0021 0.015 0.0132
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0403 0.3537 1
Giardia lamblia Kinase, NEK 0.0021 0.015 1
Echinococcus multilocularis smad 0.0007 0.0026 0.0008
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0008 0.0036 0.0018
Toxoplasma gondii hypothetical protein 0.0021 0.015 0.0139
Echinococcus multilocularis Zinc finger, RanBP2 type 0.0403 0.3537 0.3525
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0006 0.0019 0.0001
Brugia malayi hypothetical protein 0.0008 0.0036 0.0036
Echinococcus granulosus ring and YY1 binding protein 0.0403 0.3537 0.3525
Echinococcus granulosus Niemann Pick C1 protein 0.0113 0.0966 0.095
Entamoeba histolytica zinc finger domain containing protein 0.0021 0.015 0.2038
Loa Loa (eye worm) steroid hormone receptor 0.0016 0.0111 0.0111
Schistosoma mansoni ferritin 0.0007 0.0028 0.0011
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0039 0.031 0.031
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0013 0.008 0.0063
Loa Loa (eye worm) hypothetical protein 0.0008 0.0036 0.0036
Onchocerca volvulus Protein neuralized homolog 0.0021 0.015 0.0139
Loa Loa (eye worm) hypothetical protein 0.0008 0.0036 0.0036
Echinococcus multilocularis mothers against decapentaplegic 5 0.0007 0.0026 0.0008
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0019 0.0134 0.5238
Loa Loa (eye worm) hypothetical protein 0.0021 0.015 0.015
Trichomonas vaginalis ubiquitin-protein ligase BRE1, putative 0.0021 0.015 0.0136
Brugia malayi Patched family protein 0.0005 0.001 0.001
Schistosoma mansoni nuclear receptor 0.0008 0.0036 0.0018
Entamoeba histolytica hypothetical protein 0.0029 0.0223 0.3171
Echinococcus multilocularis E3 ubiquitin protein ligase MYLIP 0.0021 0.015 0.0132
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0016 0.0111 0.0111
Echinococcus multilocularis isocitrate dehydrogenase 0.0013 0.008 0.0063
Brugia malayi AMP-binding enzyme family protein 0.0019 0.0136 0.0136
Loa Loa (eye worm) hypothetical protein 0.0403 0.3537 0.3537
Trichomonas vaginalis myo inositol monophosphatase, putative 0.003 0.023 0.0216
Loa Loa (eye worm) hypothetical protein 0.0403 0.3537 0.3537
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0019 0.0134 0.3178
Loa Loa (eye worm) hypothetical protein 0.0079 0.0666 0.0666
Echinococcus multilocularis zinc finger protein Ran binding 0.0403 0.3537 0.3525
Loa Loa (eye worm) hypothetical protein 0.0005 0.001 0.001
Echinococcus multilocularis inositol monophosphatase 1 0.003 0.023 0.0213
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0111 0.0111
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0016 0.0111 0.0111
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.015 0.0136
Plasmodium vivax RING zinc finger protein, putative 0.0021 0.015 0.0139
Onchocerca volvulus Ubiquitin thioesterase ZRANB1 homolog 0.0403 0.3537 0.353
Echinococcus granulosus ecdysone induced protein 78C 0.0016 0.0111 0.0094
Schistosoma mansoni cellular tumor antigen P53 0.004 0.0319 0.0302
Loa Loa (eye worm) isocitrate dehydrogenase 0.0013 0.008 0.008
Schistosoma mansoni ferritin light chain 0.0007 0.0028 0.0011
Brugia malayi nuclear receptor NHR-88 0.0008 0.0036 0.0036
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0007 0.0028 0.0454
Loa Loa (eye worm) patched family protein 0.0005 0.001 0.001
Chlamydia trachomatis SWIB complex protein 0.1133 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.015 0.0136
Onchocerca volvulus 0.0021 0.015 0.0139
Mycobacterium ulcerans bacterioferritin BfrA 0.0007 0.0028 0.0282
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0008 0.0036 0.0018
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0016 0.0111 0.0111
Giardia lamblia Protein 21.1 0.0021 0.015 1
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.015 0.0136
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.015 0.0376
Brugia malayi MH1 domain containing protein 0.0007 0.0026 0.0026
Leishmania major hypothetical protein, conserved 0.0403 0.3537 1
Leishmania major hypothetical protein, conserved 0.0021 0.015 0.0376
Loa Loa (eye worm) hypothetical protein 0.0005 0.001 0.001
Schistosoma mansoni ferritin 0.0007 0.0028 0.0011
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.0136 0.3115
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0016 0.0111 0.0094
Leishmania major hypothetical protein, conserved 0.0021 0.015 0.0376
Echinococcus multilocularis nuclear receptor nhr 48 0.0008 0.0036 0.0018
Loa Loa (eye worm) RING finger protein 20 0.0021 0.015 0.015
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.003 0.023 0.0604
Loa Loa (eye worm) hypothetical protein 0.0005 0.001 0.001
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.015 0.0136
Brugia malayi RING zinc finger protein 0.0021 0.015 0.015
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0019 0.0134 0.0041
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.015 0.0136
Echinococcus multilocularis ring finger protein 113a 0.0021 0.015 0.0132
Loa Loa (eye worm) hypothetical protein 0.0005 0.001 0.001
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger)/EF-hand domain pair, putative 0.0021 0.015 0.0376
Brugia malayi hypothetical protein 0.0029 0.0223 0.0223
Onchocerca volvulus 0.0403 0.3537 0.353
Echinococcus granulosus L aminoadipate semialdehyde 0.0067 0.0558 0.0541
Brugia malayi MH1 domain containing protein 0.0007 0.0026 0.0026
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0021 0.015 0.0136
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0016 0.0111 0.0111
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0008 0.0036 0.0036
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.015 0.0136
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0268 0.0254
Loa Loa (eye worm) hypothetical protein 0.0034 0.0268 0.0268
Loa Loa (eye worm) oxidoreductase 0.0006 0.0017 0.0017
Trichomonas vaginalis hypothetical protein 0.0021 0.015 0.0136
Schistosoma mansoni hypothetical protein 0.0328 0.2868 0.2856
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0008 0.0036 0.0018
Loa Loa (eye worm) hypothetical protein 0.0014 0.0094 0.0094
Trypanosoma brucei hypothetical protein, conserved 0.0403 0.3537 1
Trypanosoma brucei UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0021 0.015 0.0376
Loa Loa (eye worm) hypothetical protein 0.0021 0.015 0.015
Echinococcus multilocularis protein patched 0.0034 0.0268 0.0251
Leishmania major DNA repair protein-like protein 0.0021 0.015 0.0376
Brugia malayi F/Y-rich N-terminus family protein 0.0007 0.003 0.003
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0021 0.015 0.0376
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.003 0.023 0.0604
Loa Loa (eye worm) hypothetical protein 0.0014 0.0094 0.0094
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.015 0.0136
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0021 0.015 0.0376
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0021 0.015 0.0376
Plasmodium vivax zinc finger protein, putative 0.0021 0.015 0.0139
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0021 0.015 0.0376
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0016 0.0111 0.0101
Brugia malayi nuclear hormone receptor family member nhr-6 0.0008 0.0036 0.0036
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0013 0.008 0.007
Onchocerca volvulus 0.0019 0.0136 0.0126
Echinococcus granulosus E3 ubiquitin protein ligase mib1 0.0021 0.015 0.0132
Toxoplasma gondii isocitrate dehydrogenase 0.0013 0.008 0.007
Brugia malayi protein C24B5.3 0.0005 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0005 0.001 0.001
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.1133 1 1
Giardia lamblia Protein 21.1 0.0021 0.015 1
Echinococcus multilocularis 0.0021 0.015 0.0132
Schistosoma mansoni smad1 5 8 and 0.0007 0.0026 0.0008
Giardia lamblia Protein 21.1 0.0021 0.015 1
Schistosoma mansoni cpg binding protein 0.0023 0.0172 0.0155
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0067 0.0558 0.0541
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0021 0.015 0.0376
Loa Loa (eye worm) hypothetical protein 0.0005 0.001 0.001
Onchocerca volvulus RING finger protein 141 homolog 0.0021 0.015 0.0139
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0006 0.0017 0.0177
Trichomonas vaginalis ferritin, putative 0.0007 0.0028 0.0014
Plasmodium vivax E3 ubiquitin-protein ligase RNF5, putative 0.0021 0.015 0.0139
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0026 0.0203 0.4947
Brugia malayi nuclear hormone receptor family member odr-7 0.0008 0.0036 0.0036
Toxoplasma gondii RING zinc finger protein 0.0021 0.015 0.0139
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0019 0.0134 0.0124
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.015 0.0136
Plasmodium falciparum E3 ubiquitin-protein ligase RNF5, putative 0.0021 0.015 0.0139
Entamoeba histolytica zinc finger domain containing protein 0.0021 0.015 0.2038
Brugia malayi nuclear hormone receptor 0.0016 0.0111 0.0111
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0016 0.0111 0.0111
Brugia malayi Patched family protein 0.0005 0.001 0.001
Schistosoma mansoni hypothetical protein 0.0021 0.015 0.0132
Schistosoma mansoni cpg binding protein 0.0024 0.0183 0.0166
Loa Loa (eye worm) hypothetical protein 0.0006 0.0017 0.0017
Brugia malayi hypothetical protein 0.0005 0.001 0.001
Echinococcus multilocularis dnaJ subfamily B 0.0328 0.2868 0.2856
Mycobacterium ulcerans bacterioferritin BfrB 0.0007 0.0028 0.0282
Loa Loa (eye worm) hypothetical protein 0.0005 0.001 0.001
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0013 0.008 0.1792
Echinococcus granulosus inositol monophosphatase 1 0.003 0.023 0.0213
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0006 0.0017 0.0177
Echinococcus multilocularis RING finger protein 185 0.0021 0.015 0.0132
Brugia malayi Nuclear hormone receptor-like 1 0.0009 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0005 0.001 0.001
Leishmania major 4-coumarate:coa ligase-like protein 0.0019 0.0136 0.0337
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0006 0.0019 0.0001
Echinococcus granulosus tumor protein p63 0.0271 0.2364 0.235
Schistosoma mansoni hypothetical protein 0.0029 0.0223 0.0206
Loa Loa (eye worm) patched family protein 0.0005 0.001 0.001
Brugia malayi Zinc finger protein 183 homolog 0.0021 0.015 0.015
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.1133 1 1
Echinococcus multilocularis ferritin 0.0007 0.0028 0.0011
Entamoeba histolytica myo-inositol monophosphatase, putative 0.003 0.023 0.3276
Entamoeba histolytica zinc finger domain containing protein 0.0021 0.015 0.2038
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0008 0.0036 0.0018
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0021 0.015 0.0376
Trypanosoma cruzi Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.0021 0.015 0.0376
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0019 0.0136 0.6416
Echinococcus multilocularis FTZ F1 alpha 0.0016 0.0111 0.0094
Plasmodium vivax hypothetical protein, conserved 0.1133 1 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0029 0.0223 0.0206
Toxoplasma gondii Zn-finger in Ran binding protein and others domain-containing protein 0.0403 0.3537 0.353
Brugia malayi tailless protein 0.0008 0.0036 0.0036
Schistosoma mansoni transcription factor LCR-F1 0.0029 0.0223 0.0206
Loa Loa (eye worm) hypothetical protein 0.0009 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0005 0.001 0.001
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0019 0.0134 0.0124
Schistosoma mansoni inositol monophosphatase 0.003 0.023 0.0213
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0013 0.008 0.0063
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0007 0.0026 0.0008
Echinococcus granulosus ring finger protein 113a 0.0021 0.015 0.0132
Brugia malayi Patched family protein 0.0005 0.001 0.001
Echinococcus granulosus smad 0.0007 0.0026 0.0008
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0006 0.0017 0.0007
Loa Loa (eye worm) hypothetical protein 0.0021 0.015 0.015
Loa Loa (eye worm) hypothetical protein 0.0005 0.001 0.001
Echinococcus granulosus expressed conserved protein 0.0074 0.0624 0.0607
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0403 0.3537 1
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0007 0.0026 0.0008
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0016 0.0111 0.0094
Loa Loa (eye worm) hypothetical protein 0.0014 0.0094 0.0094
Entamoeba histolytica hypothetical protein 0.0019 0.0134 0.1795
Echinococcus granulosus Niemann Pick C1 protein 0.0079 0.0666 0.065
Schistosoma mansoni steroid hormone receptor ad4bp 0.0016 0.0111 0.0094
Giardia lamblia Protein 21.1 0.0021 0.015 1
Leishmania major hypothetical protein 0.0021 0.015 0.0376
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0403 0.3537 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0008 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0019 0.0136 0.0136
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0034 0.0268 0.0268
Giardia lamblia Protein 21.1 0.0021 0.015 1
Entamoeba histolytica zinc finger domain containing protein 0.0021 0.015 0.2038
Leishmania major hypothetical protein, conserved 0.0403 0.3537 1
Leishmania major hypothetical protein, conserved 0.0021 0.015 0.0376
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0013 0.008 0.0178
Plasmodium vivax acyl-CoA synthetase, putative 0.0014 0.0094 0.0083
Loa Loa (eye worm) hypothetical protein 0.0019 0.0136 0.0136
Brugia malayi TAR-binding protein 0.0051 0.0417 0.0417
Loa Loa (eye worm) hypothetical protein 0.0009 0.0044 0.0044
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.015 0.0136
Schistosoma mansoni nuclear hormone receptor 0.0008 0.0036 0.0018
Loa Loa (eye worm) hypothetical protein 0.0008 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0016 0.0111 0.0111
Schistosoma mansoni rnf5 0.0021 0.015 0.0132
Schistosoma mansoni zinc finger protein 0.0403 0.3537 0.3525
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0006 0.0017 0.0177
Plasmodium vivax DNA repair protein RAD5, putative 0.0021 0.015 0.0139
Schistosoma mansoni TRABID protein (C64 family) 0.0403 0.3537 0.3525
Brugia malayi hypothetical protein 0.0009 0.0044 0.0044
Echinococcus granulosus TGF beta signal transducer SmadC 0.0007 0.0026 0.0008
Toxoplasma gondii hypothetical protein 0.0021 0.015 0.0139
Loa Loa (eye worm) RiNg Finger protein family member 0.0021 0.015 0.015
Leishmania major hypothetical protein, conserved 0.0403 0.3537 1
Brugia malayi Hypothetical RING finger protein C16C10.7 in chromosome III 0.0021 0.015 0.015
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0008 0.0036 0.0018
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0019 0.0136 0.3115
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.1133 1 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0094 0.0094
Loa Loa (eye worm) hypothetical protein 0.0005 0.001 0.001
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0136 0.3237
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0016 0.0111 0.0111
Brugia malayi conserved hypotetical protein 0.0008 0.0036 0.0036
Giardia lamblia Protein 21.1 0.0021 0.015 1
Entamoeba histolytica SPRY domain protein 0.0021 0.015 0.2038
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0008 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0005 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0005 0.001 0.001
Brugia malayi MH2 domain containing protein 0.0007 0.0026 0.0026
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0013 0.008 0.0063
Loa Loa (eye worm) patched family protein 0.0005 0.001 0.001
Schistosoma mansoni mind bomb 0.0021 0.015 0.0132
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0016 0.0111 0.0094
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.015 0.0136
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.015 0.0136
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger)/EF-hand domain pair, putative 0.0021 0.015 0.0376
Leishmania major hypothetical protein, conserved 0.0021 0.015 0.0376
Loa Loa (eye worm) hypothetical protein 0.0008 0.0036 0.0036
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0021 0.015 0.0136
Onchocerca volvulus Protein ultraspiracle homolog 0.0016 0.0111 0.0101
Trypanosoma brucei hypothetical protein, conserved 0.0403 0.3537 1
Trichomonas vaginalis cell cycle control protein cwf24, putative 0.0021 0.015 0.0136
Trypanosoma cruzi hypothetical protein, conserved 0.0403 0.3537 1
Schistosoma mansoni ferritin light chain 0.0007 0.0028 0.0011
Brugia malayi Steroid receptor seven-up type 2 0.0016 0.0111 0.0111
Echinococcus granulosus ring finger protein 170 0.0021 0.015 0.0132
Schistosoma mansoni apoferritin-2 0.0007 0.0028 0.0011
Onchocerca volvulus Bile acid receptor homolog 0.0016 0.0111 0.0101
Loa Loa (eye worm) hypothetical protein 0.0005 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0019 0.0136 0.0136
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0021 0.015 0.0376
Loa Loa (eye worm) hypothetical protein 0.0016 0.0111 0.0111
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0021 0.015 0.0376
Brugia malayi ecdysone receptor 0.0008 0.0036 0.0036
Mycobacterium ulcerans acyl-CoA synthetase 0.0019 0.0136 0.3115
Schistosoma mansoni retinoic acid receptor RXR 0.0016 0.0111 0.0094
Onchocerca volvulus 0.0021 0.015 0.0139
Schistosoma mansoni nuclear receptor 0.0008 0.0036 0.0018
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.015 0.0136
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0016 0.0111 0.0094
Loa Loa (eye worm) hypothetical protein 0.0008 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0005 0.001 0.001
Echinococcus multilocularis SWI:SNF matrix associated 0.1133 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.015 0.0136
Schistosoma mansoni hypothetical protein 0.0033 0.0257 0.024
Loa Loa (eye worm) transcription factor SMAD2 0.0096 0.0815 0.0815
Echinococcus multilocularis Niemann Pick C1 protein 0.0113 0.0966 0.095
Schistosoma mansoni thyroid hormone receptor 0.0016 0.0111 0.0094
Giardia lamblia Protein 21.1 0.0021 0.015 1
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.015 0.0136
Giardia lamblia Protein 21.1 0.0021 0.015 1
Brugia malayi hypothetical protein 0.0009 0.0044 0.0044
Trichomonas vaginalis inositol monophosphatase, putative 0.003 0.023 0.0216
Loa Loa (eye worm) hypothetical protein 0.0005 0.001 0.001
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0049 0.0399 1
Schistosoma mansoni peter pan-related 0.0021 0.015 0.0132
Onchocerca volvulus 0.0039 0.031 0.03
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.003 0.023 0.0604
Brugia malayi Isocitrate dehydrogenase 0.0013 0.008 0.008
Toxoplasma gondii propionate-CoA ligase 0.0006 0.0017 0.0007
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0029 0.0223 0.0206
Loa Loa (eye worm) hypothetical protein 0.0005 0.001 0.001
Echinococcus granulosus Protein patched homolog 1 0.0034 0.0268 0.0251
Brugia malayi Patched family protein 0.0005 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0005 0.001 0.001
Leishmania major hypothetical protein, conserved 0.0021 0.015 0.0376
Plasmodium falciparum zinc finger Ran-binding domain-containing protein 2, putative 0.0403 0.3537 0.353
Echinococcus multilocularis survival motor neuron protein 1 0.0189 0.1645 0.163
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0006 0.0019 0.0001
Trypanosoma brucei Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.0021 0.015 0.0376
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0006 0.0017 0.0177
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0016 0.0111 0.0094
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0016 0.0111 0.0094
Brugia malayi Patched family protein 0.0005 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0403 0.3537 0.3537
Loa Loa (eye worm) hypothetical protein 0.0009 0.0044 0.0044
Leishmania major hypothetical protein, conserved 0.0403 0.3537 1
Schistosoma mansoni hypothetical protein 0.0021 0.015 0.0132
Echinococcus multilocularis E3 ubiquitin protein ligase mib1 0.0021 0.015 0.0132
Echinococcus multilocularis expressed conserved protein 0.0074 0.0624 0.0607
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0013 0.0087 0.1965
Loa Loa (eye worm) hypothetical protein 0.0005 0.001 0.001
Leishmania major hypothetical protein, conserved 0.0021 0.015 0.0376
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0051 0.0417 0.0417
Brugia malayi MH2 domain containing protein 0.0096 0.0815 0.0815
Echinococcus granulosus E3 ubiquitin protein ligase Bre1 0.0021 0.015 0.0132
Trypanosoma brucei Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0403 0.3537 1
Brugia malayi nuclear receptor NHR-67 0.0008 0.0036 0.0036
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0016 0.0111 0.0111
Plasmodium falciparum acyl-CoA synthetase 0.0014 0.0094 0.0083
Toxoplasma gondii hypothetical protein 0.0021 0.015 0.0139
Echinococcus granulosus E3 ubiquitin protein ligase LRSAM1 0.0021 0.015 0.0132
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0049 0.0399 0.0382
Echinococcus multilocularis ring and YY1 binding protein 0.0403 0.3537 0.3525
Loa Loa (eye worm) hypothetical protein 0.0005 0.001 0.001
Onchocerca volvulus 0.0403 0.3537 0.353
Echinococcus multilocularis cpg binding protein 0.0024 0.0183 0.0166
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0016 0.0111 0.0094
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0016 0.0111 0.0111
Leishmania major hypothetical protein, conserved 0.0021 0.015 0.0376
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0079 0.0666 1
Brugia malayi Patched family protein 0.0005 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0005 0.001 0.001
Brugia malayi nuclear receptor RXR 0.0009 0.0044 0.0044
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0021 0.015 0.0376
Echinococcus granulosus dnaJ subfamily B 0.0328 0.2868 0.2856
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.015 0.0136
Leishmania major phosphopantetheinyl transferase-like protein 0.0019 0.0134 0.0331
Loa Loa (eye worm) hypothetical protein 0.0016 0.0111 0.0111
Giardia lamblia Protein 21.1 0.0021 0.015 1
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.015 0.0376
Toxoplasma gondii hypothetical protein 0.0021 0.015 0.0139
Echinococcus multilocularis protein dispatched 1 0.0039 0.031 0.0293
Brugia malayi hypothetical protein 0.0021 0.015 0.015
Brugia malayi Nuclear hormone receptor E75 0.0008 0.0036 0.0036
Echinococcus granulosus Nuclear pore complex protein Nup153 0.0403 0.3537 0.3525
Toxoplasma gondii zinc finger, C3HC4 type (RING finger) domain-containing protein 0.0021 0.015 0.0139
Brugia malayi Nuclear hormone receptor E75 0.0008 0.0036 0.0036
Giardia lamblia Protein 21.1 0.0021 0.015 1
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0013 0.008 0.0178
Giardia lamblia Ser/Thr protein kinase 0.0021 0.015 1
Brugia malayi Patched family protein 0.0005 0.001 0.001
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0016 0.0111 0.0094
Echinococcus granulosus cell growth regulator with ring finger domain 0.0021 0.015 0.0132
Brugia malayi hypothetical protein 0.0005 0.001 0.001
Entamoeba histolytica zinc finger domain containing protein 0.0021 0.015 0.2038
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.015 0.0136
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0006 0.0017 0.0177
Loa Loa (eye worm) hypothetical protein 0.0021 0.015 0.015
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0021 0.015 0.0376
Loa Loa (eye worm) Smad1 0.0007 0.0026 0.0026
Schistosoma mansoni ferritin 0.0007 0.0028 0.0011
Echinococcus granulosus Nuclear hormone receptor HR96 0.0008 0.0036 0.0018
Loa Loa (eye worm) hypothetical protein 0.0005 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0067 0.0558 0.0558
Trypanosoma cruzi Ankyrin repeats (3 copies)/Zinc finger, C3HC4 type (RING finger), putative 0.0021 0.015 0.0376
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0008 0.0036 0.0025
Loa Loa (eye worm) hypothetical protein 0.0014 0.0094 0.0094
Echinococcus granulosus Zinc finger RanBP2 type 0.0403 0.3537 0.3525
Leishmania major hypothetical protein, conserved 0.0021 0.015 0.0376
Onchocerca volvulus 0.0006 0.0017 0.0007
Toxoplasma gondii zinc finger, C3HC4 type (RING finger) domain-containing protein 0.0021 0.015 0.0139
Toxoplasma gondii SWI2/SNF2-containing protein RAD5 0.0021 0.015 0.0139
Brugia malayi ecdysteroid receptor 0.0016 0.0111 0.0111
Leishmania major 4-coumarate:coa ligase-like protein 0.0019 0.0136 0.0337
Toxoplasma gondii histone lysine methyltransferase SET1 0.0044 0.0354 0.0344
Brugia malayi Inositol-1 0.003 0.023 0.023
Entamoeba histolytica acyl-coA synthetase, putative 0.0019 0.0136 0.183
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.015 0.0376
Trypanosoma cruzi hypothetical protein 0.0021 0.015 0.0376
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.015 0.0136
Echinococcus granulosus thyroid hormone receptor alpha 0.0008 0.0036 0.0018
Plasmodium falciparum trophozoite exported protein 1 0.0021 0.015 0.0139
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0021 0.015 0.0376
Loa Loa (eye worm) hypothetical protein 0.0008 0.0036 0.0036
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0021 0.015 0.0136
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.015 0.0136
Loa Loa (eye worm) hypothetical protein 0.0008 0.0036 0.0036
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0021 0.015 0.0376
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.1133 1 1
Giardia lamblia Protein 21.1 0.0021 0.015 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0335 0.0335
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0016 0.0111 0.0094
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0006 0.0019 0.0001
Brugia malayi Zinc finger, C2H2 type family protein 0.0021 0.015 0.015
Mycobacterium ulcerans aldehyde dehydrogenase 0.0049 0.0399 1
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0403 0.3537 0.3537
Brugia malayi CHE-14 protein 0.0034 0.0268 0.0268
Loa Loa (eye worm) hypothetical protein 0.0008 0.0036 0.0036
Trichomonas vaginalis sex-determining protein fem-1, putative 0.0021 0.015 0.0136
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0021 0.015 0.0376
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0019 0.0136 0.3115
Loa Loa (eye worm) patched family protein 0.0005 0.001 0.001
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0008 0.0036 0.0025
Entamoeba histolytica acyl-CoA synthetase, putative 0.0019 0.0136 0.183
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0067 0.0558 0.0558
Plasmodium falciparum RING zinc finger protein, putative 0.0021 0.015 0.0139
Trichomonas vaginalis ion channel nompc, putative 0.0021 0.015 0.0136
Loa Loa (eye worm) MH2 domain-containing protein 0.0007 0.0026 0.0026
Brugia malayi RING finger protein 20 0.0021 0.015 0.015
Onchocerca volvulus 0.0008 0.0036 0.0025
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.015 0.0376
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0016 0.0111 0.0111
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0009 0.0044 0.0026
Brugia malayi hypothetical protein 0.0189 0.1645 0.1645
Giardia lamblia Protein 21.1 0.0021 0.015 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.0036 0.0036
Schistosoma mansoni smad1 5 8 and 0.0007 0.0026 0.0008
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0013 0.0087 0.1965
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0014 0.0094 0.2142
Schistosoma mansoni cpg binding protein 0.0024 0.0183 0.0166
Brugia malayi brahma associated protein 60 kDa 0.1133 1 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0111 0.0111
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0016 0.0111 0.0094
Trypanosoma cruzi Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.0021 0.015 0.0376
Onchocerca volvulus 0.0021 0.015 0.0139
Leishmania major hypothetical protein, conserved 0.0021 0.015 0.0376
Entamoeba histolytica zinc finger domain containing protein 0.0021 0.015 0.2038
Mycobacterium ulcerans aldehyde dehydrogenase 0.0049 0.0399 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0019 0.0136 0.3115
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0006 0.0017 0.0017
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0013 0.008 0.007
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0403 0.3537 1
Brugia malayi AMP-binding enzyme family protein 0.0006 0.0017 0.0017
Schistosoma mansoni hypothetical protein 0.1133 1 1
Onchocerca volvulus 0.0006 0.0017 0.0007
Giardia lamblia Protein 21.1 0.0021 0.015 1
Brugia malayi AMP-binding enzyme family protein 0.0019 0.0136 0.0136
Mycobacterium leprae conserved hypothetical protein 0.0019 0.0134 0.6291
Giardia lamblia Protein 21.1 0.0021 0.015 1
Brugia malayi CXXC zinc finger family protein 0.0023 0.0172 0.0172
Giardia lamblia Protein 21.1 0.0021 0.015 1
Loa Loa (eye worm) hypothetical protein 0.0403 0.3537 0.3537
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0007 0.0028 0.0581
Schistosoma mansoni aldehyde dehydrogenase 0.0049 0.0399 0.0382
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0016 0.0111 0.0111
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0021 0.015 0.0376
Trichomonas vaginalis ankyrin repeat domain protein, putative 0.0021 0.015 0.0136
Echinococcus multilocularis L aminoadipate semialdehyde 0.0067 0.0558 0.0541
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0006 0.0017 0.0017
Schistosoma mansoni thyroid hormone receptor 0.0016 0.0111 0.0094
Echinococcus granulosus zinc finger protein Ran binding 0.0403 0.3537 0.3525
Echinococcus multilocularis ecdysone induced protein 78C 0.0016 0.0111 0.0094
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0019 0.0134 0.0124
Echinococcus granulosus ferritin 0.0007 0.0028 0.0011
Leishmania major hypothetical protein, conserved 0.0021 0.015 0.0376
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0013 0.008 0.0063
Onchocerca volvulus 0.0006 0.0017 0.0007
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0021 0.015 0.0376
Mycobacterium ulcerans aldehyde dehydrogenase 0.0049 0.0399 1
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.1133 1 1
Echinococcus granulosus Smad4 0.0007 0.0026 0.0008
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0049 0.0399 0.1083
Entamoeba histolytica acyl-CoA synthetase, putative 0.0019 0.0136 0.183
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0049 0.0399 0.0382
Loa Loa (eye worm) patched family protein 0.0005 0.001 0.001
Loa Loa (eye worm) RNA binding protein 0.0051 0.0417 0.0417
Loa Loa (eye worm) brahma associated protein 0.1133 1 1
Onchocerca volvulus 0.0021 0.015 0.0139
Brugia malayi RNA binding protein 0.0051 0.0417 0.0417
Schistosoma mansoni niemann-pick C1 (NPC1) 0.008 0.0677 0.0661
Loa Loa (eye worm) hypothetical protein 0.0005 0.001 0.001
Brugia malayi photoreceptor-specific nuclear receptor 0.0016 0.0111 0.0111
Loa Loa (eye worm) hypothetical protein 0.0021 0.015 0.015
Brugia malayi nuclear receptor NHR-88 0.0016 0.0111 0.0111
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.015 0.0136
Loa Loa (eye worm) nuclear receptor NHR-67 0.0008 0.0036 0.0036
Entamoeba histolytica hypothetical protein 0.0021 0.015 0.2038
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0013 0.008 0.0178
Trypanosoma brucei ring finger containing protein 0.0021 0.015 0.0376
Schistosoma mansoni tar DNA-binding protein 0.0051 0.0417 0.04
Brugia malayi steroid hormone receptor 0.0016 0.0111 0.0111
Trypanosoma brucei Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.0021 0.015 0.0376
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0006 0.0017 0.0177
Mycobacterium ulcerans acyl-CoA synthetase 0.0019 0.0136 0.3115
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0013 0.008 0.0178
Trypanosoma cruzi WLM domain containing protein, putative 0.0403 0.3537 1
Schistosoma mansoni tar DNA-binding protein 0.0051 0.0417 0.04
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0111 0.0094
Echinococcus granulosus mixed lineage leukemia protein mll 0.0006 0.0019 0.0001
Loa Loa (eye worm) hypothetical protein 0.0008 0.0036 0.0036
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0019 0.0134 1
Loa Loa (eye worm) hypothetical protein 0.0005 0.001 0.001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0016 0.0111 0.0111
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0013 0.0087 0.1965
Brugia malayi Nuclear hormone receptor-like 1 0.0009 0.0044 0.0044
Trypanosoma cruzi hypothetical protein, conserved 0.0403 0.3537 1
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0403 0.3537 0.3537
Trypanosoma cruzi hypothetical protein, conserved 0.0403 0.3537 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.003 0.023 0.0216
Loa Loa (eye worm) hypothetical protein 0.0009 0.0044 0.0044
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.015 0.0136
Echinococcus granulosus mothers against decapentaplegic 5 0.0007 0.0026 0.0008
Loa Loa (eye worm) hypothetical protein 0.0006 0.0017 0.0017
Brugia malayi hypothetical protein 0.0021 0.015 0.015
Brugia malayi SWIB/MDM2 domain containing protein 0.1133 1 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0008 0.0036 0.0018
Brugia malayi Myosin head containing protein 0.0005 0.001 0.001
Brugia malayi nuclear receptor RXR 0.0008 0.0036 0.0036
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.003 0.023 1
Echinococcus granulosus RING finger protein 185 0.0021 0.015 0.0132
Toxoplasma gondii ran binding protein 0.0403 0.3537 0.353
Echinococcus multilocularis tumor protein p63 0.0271 0.2364 0.235
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0016 0.0111 0.0111
Trichomonas vaginalis conserved hypothetical protein 0.1133 1 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0016 0.0111 0.0094
Trypanosoma brucei DNA repair protein, putative 0.0021 0.015 0.0376
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0021 0.015 0.0376
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0016 0.0111 0.0094
Schistosoma mansoni inositol monophosphatase 0.003 0.023 0.0213
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.1133 1 1
Schistosoma mansoni hypothetical protein 0.1133 1 1
Loa Loa (eye worm) DR-78 0.0008 0.0036 0.0036
Leishmania major hypothetical protein, unknown function 0.0021 0.015 0.0376
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.065 0.5717 0.571
Giardia lamblia Protein 21.1 0.0021 0.015 1
Echinococcus multilocularis SWI:SNF matrix associated 0.1133 1 1
Schistosoma mansoni nuclear hormone receptor 0.0016 0.0111 0.0094
Entamoeba histolytica zinc finger domain containing protein 0.0021 0.015 0.2038
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.003 0.023 0.022
Schistosoma mansoni survival motor neuron protein 0.0039 0.031 0.0293
Loa Loa (eye worm) hypothetical protein 0.0021 0.015 0.015
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.015 0.0376
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.003 0.023 0.0604
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0016 0.0111 0.0111
Trypanosoma cruzi Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0403 0.3537 1
Schistosoma mansoni tar DNA-binding protein 0.0051 0.0417 0.04
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0019 0.0134 0.3055
Schistosoma mansoni hypothetical protein 0.0033 0.0257 0.024
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0006 0.0017 0.0017
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0016 0.0111 0.0111
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0031 0.0014
Schistosoma mansoni zinc finger protein 0.0008 0.0036 0.0018
Echinococcus multilocularis RING finger and transmembrane domain containing protein 0.0021 0.015 0.0132
Schistosoma mansoni inhibitor of apoptosis 1 diap1 0.0021 0.015 0.0132
Trypanosoma brucei Ankyrin repeats (3 copies)/Zinc finger, C3HC4 type (RING finger), putative 0.0021 0.015 0.0376
Echinococcus granulosus E3 ubiquitin protein ligase RNF146 0.0021 0.015 0.0132
Loa Loa (eye worm) hypothetical protein 0.0005 0.001 0.001
Giardia lamblia Protein 21.1 0.0021 0.015 1
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0006 0.0017 0.0177
Brugia malayi Patched related family protein 4 0.0005 0.001 0.001
Brugia malayi orphan nuclear receptor NR2E1 0.0008 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0021 0.015 0.015
Trypanosoma cruzi Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.0021 0.015 0.0376
Entamoeba histolytica hypothetical protein 0.0029 0.0223 0.3171
Schistosoma mansoni hypothetical protein 0.0033 0.0257 0.024
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.015 0.0132
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.015 0.0136
Brugia malayi hypothetical protein 0.0021 0.015 0.015
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0013 0.0087 0.1965
Plasmodium vivax trophozoite exported protein 1, putative 0.0021 0.015 0.0139
Loa Loa (eye worm) hypothetical protein 0.0403 0.3537 0.3537
Brugia malayi protein C24B5.3 0.0005 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0016 0.0111 0.0111
Loa Loa (eye worm) MH1 domain-containing protein 0.0007 0.0026 0.0026
Brugia malayi Neuralized family protein 0.0021 0.015 0.015
Onchocerca volvulus 0.0006 0.0017 0.0007
Schistosoma mansoni tar DNA-binding protein 0.0051 0.0417 0.04
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0009 0.0044 0.0026
Schistosoma mansoni fusion 0.0403 0.3537 0.3525
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0019 0.0136 0.3237
Giardia lamblia Protein 21.1 0.0021 0.015 1
Brugia malayi AMP-binding enzyme family protein 0.0006 0.0017 0.0017
Echinococcus multilocularis E3 ubiquitin protein ligase Bre1 0.0021 0.015 0.0132
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0009 0.0044 0.0026
Echinococcus granulosus cpg binding protein 0.0024 0.0183 0.0166
Brugia malayi AMP-binding enzyme family protein 0.0006 0.0017 0.0017
Trypanosoma cruzi Ankyrin repeats (3 copies)/Zinc finger, C3HC4 type (RING finger), putative 0.0021 0.015 0.0376
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0006 0.0017 0.0007
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0016 0.0111 0.0094
Leishmania major 4-coumarate:coa ligase-like protein 0.0019 0.0136 0.0337
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0006 0.0017 0.0017
Brugia malayi Patched related family protein 12 0.0005 0.001 0.001
Onchocerca volvulus Putative RING finger protein 207 0.0021 0.015 0.0139
Schistosoma mansoni aldehyde dehydrogenase 0.0049 0.0399 0.0382
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0403 0.3537 0.3537
Entamoeba histolytica hypothetical protein 0.0029 0.0223 0.3171
Trichomonas vaginalis ankyrin, putative 0.0021 0.015 0.0136
Onchocerca volvulus 0.0021 0.015 0.0139
Schistosoma mansoni nuclear hormone receptor 0.0008 0.0036 0.0018
Echinococcus granulosus tar DNA binding protein 0.0051 0.0417 0.04
Loa Loa (eye worm) CXXC zinc finger family protein 0.0023 0.0172 0.0172
Plasmodium falciparum zinc finger protein, putative 0.0021 0.015 0.0139
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0021 0.015 0.0376

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) = -9 % Inhibition of Platelet-derived growth factor receptor at 1 uM ChEMBL. 12941342
Inhibition (binding) = -9 % Inhibition of Platelet-derived growth factor receptor at 1 uM ChEMBL. 12941342

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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