TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 466.488 | Formula: C27H22N4O4
H donors: 1 H acceptors: 5 LogP: 3.98 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1)COc1ccc(cc1)c1cc(C(=O)O)c2c(n1)n(nc2)Cc1ccncc1
InChi: 1S/C27H22N4O4/c1-34-21-6-2-19(3-7-21)17-35-22-8-4-20(5-9-22)25-14-23(27(32)33)24-15-29-31(26(24)30-25)16-18-10-12-28-13-11-18/h2-15H,16-17H2,1H3,(H,32,33)
InChiKey: VLJKVRTVGWWMSD-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0028	0.0029
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0028	0.0029
Schistosoma mansoni	hypothetical protein	0.0012	0.0002	0.0002
Plasmodium vivax	ataxin-2 like protein, putative	0.0026	0.0104	0.013
Mycobacterium tuberculosis	Probable esterase LipL	0.0037	0.0177	0.0943
Echinococcus multilocularis	E3 ubiquitin protein ligase MYLIP	0.0015	0.0028	0.0028
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0049	0.0268	0.0453
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0028	0.0047
Schistosoma mansoni	hypothetical protein	0.0016	0.0029	0.003
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0015	0.0025
Brugia malayi	brahma associated protein 60 kDa	0.0849	0.5931	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0049	0.0263	0.0264
Schistosoma mansoni	RNA binding protein	0.0302	0.2058	0.2068
Schistosoma mansoni	smad1 5 8 and	0.0025	0.0093	0.0093
Giardia lamblia	Protein 21.1	0.0015	0.0028	1
Schistosoma mansoni	transcription factor LCR-F1	0.0037	0.0183	0.0184
Onchocerca volvulus		0.0849	0.5931	1
Echinococcus granulosus	mothers against decapentaplegic 5	0.0025	0.0093	0.0093
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.004	0.0199	0.0199
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0015	0.0028	0.0088
Brugia malayi	F/Y-rich N-terminus family protein	0.002	0.0064	0.0108
Leishmania major	hypothetical protein, conserved	0.0302	0.2058	1
Trypanosoma brucei	Zinc finger, C3HC4 type (RING finger), putative	0.0015	0.0028	0.0088
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0017	0.004	0.004
Onchocerca volvulus	Huntingtin homolog	0.0121	0.0778	0.1271
Schistosoma mansoni	hypothetical protein	0.0015	0.0028	0.0028
Leishmania major	hypothetical protein, conserved	0.0015	0.0028	0.0088
Loa Loa (eye worm)	bromodomain containing protein	0.0018	0.0044	0.0075
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0049	0.0268	0.0453
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0989	0.1667
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0028	0.0029
Brugia malayi	Bromodomain containing protein	0.0078	0.0474	0.08
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0158	0.0266
Giardia lamblia	Protein 21.1	0.0015	0.0028	1
Brugia malayi	YY1-associated factor 2	0.0302	0.2058	0.3469
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0263	0.0444
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0177	0.0819
Trypanosoma brucei	DNA repair protein, putative	0.0015	0.0028	0.0088
Trichomonas vaginalis	ankyrin, putative	0.0015	0.0028	0.0029
Trypanosoma cruzi	Zn-finger in Ran binding protein and others, putative	0.0302	0.2058	1
Leishmania major	hypothetical protein, conserved	0.0302	0.2058	1
Trypanosoma cruzi	isocitrate dehydrogenase, putative	0.0016	0.0032	0.0111
Onchocerca volvulus		0.0302	0.2058	0.3438
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0036	0.0174	0.0174
Schistosoma mansoni	hypothetical protein	0.0015	0.0027	0.0028
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0016	0.0032	0.0032
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0302	0.2058	0.3469
Echinococcus multilocularis	Nuclear pore complex protein Nup153	0.0302	0.2058	0.2058
Trypanosoma cruzi	hypothetical protein, conserved	0.0302	0.2058	1
Trichomonas vaginalis	ion channel nompc, putative	0.0015	0.0028	0.0029
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0025	0.0093	0.0093
Onchocerca volvulus	Ubiquitin thioesterase ZRANB1 homolog	0.0302	0.2058	0.3438
Giardia lamblia	Protein 21.1	0.0015	0.0028	1
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0015	0.0028	0.0088
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0061	0.0349	0.0349
Brugia malayi	CXXC zinc finger family protein	0.0057	0.0324	0.0545
Giardia lamblia	Protein 21.1	0.0015	0.0028	1
Loa Loa (eye worm)	RING finger protein 20	0.0015	0.0028	0.0047
Brugia malayi	SWIB/MDM2 domain containing protein	0.0849	0.5931	1
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0025	0.0093	0.0093
Leishmania major	hypothetical protein, conserved	0.0015	0.0028	0.0088
Brugia malayi	Latrophilin receptor protein 2	0.0016	0.0029	0.005
Echinococcus multilocularis	SWI:SNF matrix associated	0.0849	0.5931	0.5931
Giardia lamblia	Protein 21.1	0.0015	0.0028	1
Echinococcus granulosus	fetal alzheimer antigen falz	0.0026	0.0102	0.0102
Loa Loa (eye worm)	SWIB/MDM2 domain-containing protein	0.0849	0.5931	1
Chlamydia trachomatis	SWIB complex protein	0.0849	0.5931	0.5
Loa Loa (eye worm)	hypothetical protein	0.0302	0.2058	0.3469
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0028	0.0029
Trypanosoma brucei	PAB1-binding protein , putative	0.0026	0.0104	0.0462
Leishmania major	hypothetical protein, conserved	0.0015	0.0028	0.0088
Trypanosoma cruzi	hypothetical protein, conserved	0.0302	0.2058	1
Entamoeba histolytica	hypothetical protein	0.0037	0.0183	1
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0049	0.0263	0.0263
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0061	0.0349	1
Schistosoma mansoni	zinc finger protein	0.0023	0.0081	0.0081
Echinococcus granulosus	cell growth regulator with ring finger domain	0.0015	0.0028	0.0028
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0016	0.0029	0.0029
Echinococcus multilocularis	dnaJ subfamily B	0.0814	0.5683	0.5683
Brugia malayi	Cytochrome P450 family protein	0.0013	0.001	0.0016
Onchocerca volvulus	Huntingtin homolog	0.0121	0.0778	0.1271
Mycobacterium ulcerans	esterase/lipase LipP	0.0037	0.0177	0.495
Schistosoma mansoni	fusion	0.0302	0.2058	0.2068
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0028	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0028	0.0047
Echinococcus multilocularis	ring finger protein 113a	0.0015	0.0028	0.0028
Giardia lamblia	Protein 21.1	0.0015	0.0028	1
Schistosoma mansoni	zinc finger protein	0.0015	0.0028	0.0028
Leishmania major	hypothetical protein, conserved	0.0015	0.0028	0.0088
Echinococcus multilocularis	SWI:SNF matrix associated	0.0849	0.5931	0.5931
Brugia malayi	Pre-SET motif family protein	0.0212	0.1423	0.2399
Brugia malayi	PHD-finger family protein	0.0028	0.0119	0.02
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0015	0.0028	0.0029
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0037	0.0177	0.0943
Giardia lamblia	Protein 21.1	0.0015	0.0028	1
Echinococcus multilocularis	E3 ubiquitin protein ligase mib1	0.0015	0.0028	0.0028
Trypanosoma cruzi	Zinc finger, C3HC4 type (RING finger), putative	0.0015	0.0028	0.0088
Trypanosoma cruzi	mitochondrial RNA binding complex 1 subunit, putative	0.0302	0.2058	1
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0028	0.0029
Trypanosoma cruzi	PAB1-binding protein , putative	0.0026	0.0104	0.0462
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0015	0.0028	0.0088
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0028	0.0029
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0212	0.1423	0.2399
Leishmania major	hypothetical protein	0.0015	0.0028	0.0088
Brugia malayi	RING finger protein 20	0.0015	0.0028	0.0047
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0028	0.0029
Trichomonas vaginalis	cell cycle control protein cwf24, putative	0.0015	0.0028	0.0029
Echinococcus multilocularis	GPCR, family 2	0.0016	0.0029	0.0029
Giardia lamblia	Kinase, NEK	0.0015	0.0028	1
Schistosoma mansoni	smad1 5 8 and	0.0025	0.0093	0.0093
Trypanosoma brucei	Zinc finger, C3HC4 type (RING finger) containing protein, putative	0.0015	0.0028	0.0088
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0177	0.0282
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0037	0.0183	0.0183
Leishmania major	hypothetical protein, conserved	0.0015	0.0028	0.0088
Schistosoma mansoni	zinc finger protein	0.0015	0.0027	0.0028
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0032	0.0142	0.0142
Schistosoma mansoni	peter pan-related	0.0015	0.0028	0.0028
Plasmodium vivax	isocitrate dehydrogenase [NADP], mitochondrial, putative	0.0016	0.0032	0.0008
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0037	0.0181	0.0287
Echinococcus granulosus	neuropeptide s receptor	0.0462	0.3193	0.3193
Schistosoma mansoni	hypothetical protein	0.0021	0.0065	0.0066
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0032	0.0142	0.0194
Leishmania major	hypothetical protein, conserved	0.0015	0.0028	0.0088
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0057	0.0324	0.0545
Leishmania major	hypothetical protein, conserved	0.0037	0.0177	0.0819
Leishmania major	hypothetical protein, conserved	0.0302	0.2058	1
Trichomonas vaginalis	ubiquitin-protein ligase BRE1, putative	0.0015	0.0028	0.0029
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0122	0.0785	0.0789
Brugia malayi	hypothetical protein	0.0037	0.0183	0.0309
Echinococcus granulosus	smad	0.0025	0.0093	0.0093
Leishmania major	hypothetical protein, conserved	0.0015	0.0028	0.0088
Trypanosoma brucei	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0015	0.0028	0.0088
Echinococcus granulosus	SWI:SNF matrix associated	0.0849	0.5931	0.5931
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0015	0.0028	0.0088
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0016	0.0029	0.0029
Leishmania major	hypothetical protein, conserved	0.0015	0.0028	0.0088
Schistosoma mansoni	hypothetical protein	0.0037	0.0183	0.0184
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0015	0.0028	0.0029
Brugia malayi	hypothetical protein	0.0015	0.0028	0.0047
Trypanosoma brucei	hypothetical protein, conserved	0.0302	0.2058	1
Mycobacterium tuberculosis	Probable lipase LipD	0.0037	0.0177	0.0943
Chlamydia trachomatis	DNA topoisomerase I	0.0849	0.5931	0.5
Giardia lamblia	Protein 21.1	0.0015	0.0028	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0177	0.0299
Toxoplasma gondii	ABC1 family protein	0.0037	0.0177	0.0254
Schistosoma mansoni	rnf5	0.0015	0.0028	0.0028
Leishmania major	hypothetical protein, conserved	0.0302	0.2058	1
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0037	0.0177	0.0299
Brugia malayi	beta-lactamase family protein	0.0037	0.0177	0.0299
Echinococcus granulosus	ring finger protein 170	0.0015	0.0028	0.0028
Trypanosoma cruzi	hypothetical protein, conserved	0.0015	0.0028	0.0088
Brugia malayi	Cytochrome P450 family protein	0.0013	0.001	0.0016
Brugia malayi	Hypothetical RING finger protein C16C10.7 in chromosome III	0.0015	0.0028	0.0047
Giardia lamblia	Protein 21.1	0.0015	0.0028	1
Schistosoma mansoni	Smad4	0.0025	0.0093	0.0093
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0029	0.005
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0015	0.0028	0.0088
Schistosoma mansoni	hypothetical protein	0.0169	0.1118	0.1124
Trypanosoma cruzi	Zinc finger, C3HC4 type (RING finger), putative	0.0015	0.0028	0.0088
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0177	0.0299
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0037	0.0177	0.495
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0177	0.0299
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0017	0.004	0.004
Schistosoma mansoni	microtubule-associated protein tau	0.1417	0.9951	1
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0016	0.0032	0.0111
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0037	0.0181	0.0287
Echinococcus granulosus	E3 ubiquitin protein ligase mib1	0.0015	0.0028	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0778	0.1312
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0016	0.0032	0.0032
Mycobacterium ulcerans	lipase LipD	0.0037	0.0177	0.495
Echinococcus granulosus	neuropeptide receptor A26	0.0462	0.3193	0.3193
Trypanosoma cruzi	ISWI complex protein	0.0015	0.0027	0.0087
Giardia lamblia	Protein 21.1	0.0015	0.0028	1
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0268	0.0453
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0016	0.0032	0.0032
Giardia lamblia	Protein 21.1	0.0015	0.0028	1
Loa Loa (eye worm)	cytochrome P450 family protein	0.0013	0.001	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0302	0.2058	0.3469
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0028	0.0029
Brugia malayi	MH2 domain containing protein	0.0361	0.2474	0.4171
Schistosoma mansoni	cellular tumor antigen P53	0.0208	0.1394	0.1401
Giardia lamblia	Ser/Thr protein kinase	0.0015	0.0028	1
Onchocerca volvulus		0.0208	0.1394	0.2315
Brugia malayi	Smad1	0.0025	0.0093	0.0157
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0036	0.0174	0.0174
Brugia malayi	Zinc finger, C2H2 type family protein	0.0015	0.0028	0.0047
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0037	0.0177	0.0943
Onchocerca volvulus		0.0037	0.0177	0.0254
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0302	0.2058	0.3469
Trypanosoma brucei	hypothetical protein, conserved	0.0037	0.0177	0.0819
Echinococcus multilocularis	SWI:SNF matrix associated	0.0849	0.5931	0.5931
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0015	0.0028	0.0088
Giardia lamblia	Protein 21.1	0.0015	0.0028	1
Schistosoma mansoni	smad	0.0025	0.0093	0.0093
Schistosoma mansoni	hypothetical protein	0.0016	0.0029	0.003
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0016	0.0029	0.005
Trypanosoma cruzi	Ankyrin repeats (3 copies)/Zinc finger, C3HC4 type (RING finger), putative	0.0015	0.0028	0.0088
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0015	0.0028	0.0088
Mycobacterium tuberculosis	Probable lipase LipE	0.0037	0.0177	0.0943
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0019	0.0052	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0028	0.0047
Brugia malayi	hypothetical protein	0.0015	0.0028	0.0047
Schistosoma mansoni	hypothetical protein	0.0849	0.5931	0.596
Loa Loa (eye worm)	histone methyltransferase	0.0019	0.0052	0.0088
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0037	0.0177	0.0299
Schistosoma mansoni	hypothetical protein	0.0016	0.0029	0.003
Brugia malayi	B-box zinc finger family protein	0.0015	0.0028	0.0047
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0061	0.0349	1
Loa Loa (eye worm)	brahma associated protein	0.0849	0.5931	1
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0016	0.0032	0.0111
Entamoeba histolytica	hypothetical protein	0.0037	0.0183	1
Leishmania major	hypothetical protein, conserved	0.0026	0.0104	0.0462
Giardia lamblia	Protein 21.1	0.0015	0.0028	1
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0028	0.0029
Trichomonas vaginalis	hypothetical protein	0.0015	0.0028	0.0029
Onchocerca volvulus		0.0302	0.2058	0.3438
Schistosoma mansoni	mind bomb	0.0015	0.0028	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0302	0.2058	0.3469
Mycobacterium tuberculosis	Conserved protein	0.0037	0.0177	0.0943
Mycobacterium leprae	Probable lipase LipE	0.0037	0.0177	0.5
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0012	0.0002	0.0002
Trichomonas vaginalis	set domain proteins, putative	0.0242	0.1629	0.2734
Loa Loa (eye worm)	MH2 domain-containing protein	0.0361	0.2474	0.4171
Mycobacterium tuberculosis	Conserved protein	0.0037	0.0177	0.0943
Trypanosoma cruzi	mitochondrial RNA binding complex 1 subunit, putative	0.0302	0.2058	1
Echinococcus granulosus	beta LACTamase domain containing family member	0.0037	0.0177	0.0177
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0015	0.0027	0.0027
Plasmodium falciparum	ataxin-2 like protein, putative	0.0026	0.0104	0.013
Giardia lamblia	Protein 21.1	0.0015	0.0028	1
Loa Loa (eye worm)	MH2 domain-containing protein	0.0025	0.0093	0.0157
Brugia malayi	hypothetical protein	0.0015	0.0028	0.0047
Onchocerca volvulus		0.0032	0.0142	0.0194
Trypanosoma brucei	Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative	0.0015	0.0028	0.0088
Leishmania major	DNA repair protein-like protein	0.0015	0.0028	0.0088
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0015	0.0028	0.0088
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0028	0.0047
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0015	0.0028	0.0029
Schistosoma mansoni	voltage-gated potassium channel	0.0043	0.0225	0.0226
Echinococcus multilocularis	RING finger and transmembrane domain containing protein	0.0015	0.0028	0.0028
Echinococcus granulosus	Smad4	0.0025	0.0093	0.0093
Mycobacterium tuberculosis	Probable hydrolase	0.0037	0.0177	0.0943
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0026	0.0102	0.0102
Echinococcus multilocularis	E3 ubiquitin protein ligase LRSAM1	0.0015	0.0028	0.0028
Trypanosoma cruzi	Zinc finger, C3HC4 type (RING finger)/EF-hand domain pair, putative	0.0015	0.0028	0.0088
Trypanosoma brucei	Zn-finger in Ran binding protein and others/FYVE zinc finger, putative	0.0302	0.2058	1
Schistosoma mansoni	smad1 5 8 and	0.0025	0.0093	0.0093
Onchocerca volvulus		0.0302	0.2058	0.3438
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0245	0.0412
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0049	0.0263	0.0264
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0026	0.0102	0.0102
Loa Loa (eye worm)	PHD-finger family protein	0.0021	0.0065	0.011
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0028	0.0029
Trypanosoma cruzi	hypothetical protein	0.0015	0.0028	0.0088
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0177	0.0299
Trypanosoma brucei	mitochondrial RNA binding complex 1 subunit	0.0302	0.2058	1
Echinococcus granulosus	geminin	0.0169	0.1118	0.1118
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0016	0.0032	0.0032
Trypanosoma brucei	isocitrate dehydrogenase, putative	0.0016	0.0032	0.0111
Trypanosoma brucei	SNF2 family N-terminal domain/Ring finger domain containing protein, putative	0.0015	0.0028	0.0088
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0025	0.0093	0.0093
Echinococcus multilocularis	isocitrate dehydrogenase	0.0016	0.0032	0.0032
Trypanosoma cruzi	Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative	0.0015	0.0028	0.0088
Mycobacterium leprae	conserved hypothetical protein	0.0037	0.0177	0.5
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0016	0.0032	0.0111
Trypanosoma cruzi	Zinc finger, C3HC4 type (RING finger), putative	0.0015	0.0028	0.0088
Echinococcus granulosus	histone lysine methyltransferase setb	0.0049	0.0263	0.0263
Giardia lamblia	Protein 21.1	0.0015	0.0028	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0302	0.2058	1
Toxoplasma gondii	ran binding protein	0.0302	0.2058	0.3438
Toxoplasma gondii	LsmAD domain-containing protein	0.0026	0.0104	0.013
Leishmania major	hypothetical protein, unknown function	0.0015	0.0028	0.0088
Brugia malayi	hypothetical protein	0.0017	0.0038	0.0065
Giardia lamblia	Protein 21.1	0.0015	0.0028	1
Echinococcus granulosus	E3 ubiquitin protein ligase Bre1	0.0015	0.0028	0.0028
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0028	0.0029
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0233	0.1571	1
Echinococcus multilocularis	E3 ubiquitin protein ligase Bre1	0.0015	0.0028	0.0028
Brugia malayi	Neuralized family protein	0.0015	0.0028	0.0047
Trichomonas vaginalis	ankyrin 2,3/unc44, putative	0.0015	0.0028	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0028	0.0047
Echinococcus multilocularis	cpg binding protein	0.0062	0.036	0.036
Echinococcus granulosus	dnaJ subfamily B	0.0814	0.5683	0.5683
Trichomonas vaginalis	ankyrin, putative	0.0015	0.0028	0.0029
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0177	0.0819
Trypanosoma brucei	ring finger containing protein	0.0015	0.0028	0.0088
Mycobacterium ulcerans	hypothetical protein	0.0037	0.0177	0.495
Echinococcus granulosus	zinc finger protein Ran binding	0.0302	0.2058	0.2058
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0028	0.0047
Toxoplasma gondii	Zn-finger in Ran binding protein and others domain-containing protein	0.0302	0.2058	0.3438
Schistosoma mansoni	bromodomain containing protein	0.0067	0.0391	0.0393
Brugia malayi	beta-lactamase family protein	0.0037	0.0177	0.0299
Schistosoma mansoni	TRABID protein (C64 family)	0.0302	0.2058	0.2068
Trypanosoma brucei	Zinc finger, C3HC4 type (RING finger), putative	0.0015	0.0028	0.0088
Giardia lamblia	Protein 21.1	0.0015	0.0028	1
Echinococcus multilocularis	geminin	0.0169	0.1118	0.1118
Plasmodium falciparum	ataxin-2 like protein, putative	0.0026	0.0104	0.013
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0016	0.0029	0.0029
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0302	0.2058	0.3469
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0028	0.0047
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0028	0.0029
Echinococcus granulosus	zinc finger protein	0.0023	0.0081	0.0081
Echinococcus multilocularis	ring finger protein 170	0.0015	0.0028	0.0028
Echinococcus granulosus	ring finger protein 113a	0.0015	0.0028	0.0028
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0015	0.0027	0.0027
Schistosoma mansoni	cpg binding protein	0.0062	0.036	0.0362
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0811	0.5659	0.5659
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0049	0.0268	0.0453
Trypanosoma cruzi	Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative	0.0015	0.0028	0.0088
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0061	0.0349	0.0349
Toxoplasma gondii	isocitrate dehydrogenase	0.0016	0.0032	0.0008
Trichomonas vaginalis	sex-determining protein fem-1, putative	0.0015	0.0028	0.0029
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0029	0.0125	0.0125
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0015	0.0027	0.0027
Echinococcus granulosus	Upstream activation factor subunit UAF30	0.0849	0.5931	0.5931
Brugia malayi	MH2 domain containing protein	0.0025	0.0093	0.0157
Brugia malayi	Isocitrate dehydrogenase	0.0016	0.0032	0.0054
Trypanosoma brucei	Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative	0.0015	0.0028	0.0088
Trypanosoma cruzi	hypothetical protein, conserved	0.0015	0.0028	0.0088
Giardia lamblia	Protein 21.1	0.0015	0.0028	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0015	0.0028	0.0088
Schistosoma mansoni	hypothetical protein	0.0015	0.0028	0.0028
Trypanosoma cruzi	Zinc finger, C3HC4 type (RING finger)/EF-hand domain pair, putative	0.0015	0.0028	0.0088
Trypanosoma cruzi	Zinc finger, C3HC4 type (RING finger), putative	0.0015	0.0028	0.0088
Schistosoma mansoni	aldehyde dehydrogenase	0.0061	0.0349	0.035
Onchocerca volvulus		0.0037	0.0177	0.0254
Giardia lamblia	Protein 21.1	0.0015	0.0028	1
Echinococcus granulosus	RING finger protein 185	0.0015	0.0028	0.0028
Schistosoma mansoni	hypothetical protein	0.0169	0.1118	0.1124
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0015	0.0028	0.0088
Onchocerca volvulus		0.0302	0.2058	0.3438
Leishmania major	hypothetical protein, conserved	0.0015	0.0028	0.0088
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0028	0.0029
Schistosoma mansoni	zinc finger protein	0.0302	0.2058	0.2068
Trypanosoma cruzi	Zn-finger in Ran binding protein and others, putative	0.0302	0.2058	1
Trypanosoma cruzi	PAB1-binding protein , putative	0.0026	0.0104	0.0462
Trypanosoma brucei	Zinc finger, C3HC4 type (RING finger), putative	0.0015	0.0028	0.0088
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0028	0.0029
Brugia malayi	hypothetical protein	0.0026	0.0104	0.0176
Trichomonas vaginalis	ubiquitin-protein ligase BRE1, putative	0.0015	0.0028	0.0029
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0028	0.0029
Trypanosoma brucei	Zinc finger, C3HC4 type (RING finger), putative	0.0015	0.0028	0.0088
Brugia malayi	MH2 domain containing protein	0.0025	0.0093	0.0157
Loa Loa (eye worm)	MH1 domain-containing protein	0.0025	0.0093	0.0157
Toxoplasma gondii	isocitrate dehydrogenase	0.0016	0.0032	0.0008
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0019	0.0052	0.0052
Schistosoma mansoni	inhibitor of apoptosis 1 diap1	0.0015	0.0028	0.0028
Leishmania major	hypothetical protein, conserved	0.0015	0.0028	0.0088
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0028	0.0029
Giardia lamblia	Protein 21.1	0.0015	0.0028	1
Echinococcus multilocularis	Upstream activation factor subunit UAF30	0.0849	0.5931	0.5931
Echinococcus multilocularis	ring and YY1 binding protein	0.0302	0.2058	0.2058
Trypanosoma cruzi	Zinc finger, C3HC4 type (RING finger), putative	0.0015	0.0028	0.0088
Schistosoma mansoni	hypothetical protein	0.0849	0.5931	0.596
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0025	0.0093	0.0093
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0028	0.0047
Trypanosoma cruzi	Zn-finger in Ran binding protein and others/FYVE zinc finger, putative	0.0302	0.2058	1
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0015	0.0027	0.0027
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0142	0.0143
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0028	0.0029
Entamoeba histolytica	hypothetical protein	0.0037	0.0183	1
Plasmodium vivax	SWIB/MDM2 domain-containing protein, putative	0.0849	0.5931	1
Plasmodium vivax	SET domain protein, putative	0.0032	0.0142	0.0194
Loa Loa (eye worm)	hypothetical protein	0.0208	0.1394	0.2351
Loa Loa (eye worm)	nuclear factor I	0.0014	0.0015	0.0025
Trypanosoma cruzi	Zinc finger, C3HC4 type (RING finger), putative	0.0015	0.0028	0.0088
Echinococcus multilocularis	neuropeptide receptor A26	0.0462	0.3193	0.3193
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0028	0.0029
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0028	0.0029
Echinococcus granulosus	Nuclear pore complex protein Nup153	0.0302	0.2058	0.2058
Leishmania major	hypothetical protein, conserved	0.0302	0.2058	1
Onchocerca volvulus		0.0037	0.0177	0.0254
Schistosoma mansoni	voltage-gated potassium channel	0.0043	0.0225	0.0226
Onchocerca volvulus		0.0057	0.0324	0.0501
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0191	0.0322
Echinococcus multilocularis	zinc finger protein	0.0023	0.0081	0.0081
Echinococcus granulosus	methyl CpG binding domain protein 2	0.0017	0.004	0.004
Brugia malayi	Bromodomain containing protein	0.0038	0.0191	0.0322
Echinococcus granulosus	cpg binding protein	0.0062	0.036	0.036
Mycobacterium ulcerans	beta-lactamase	0.0037	0.0177	0.495
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0016	0.0032	0.0032
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0028	0.0029
Echinococcus multilocularis	methyl CpG binding domain protein 2	0.0017	0.004	0.004
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.004	0.0199	0.0199
Plasmodium falciparum	SWIB/MDM2 domain-containing protein	0.0849	0.5931	1
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0016	0.0029	0.0029
Echinococcus granulosus	ring and YY1 binding protein	0.0302	0.2058	0.2058
Echinococcus granulosus	Zinc finger RanBP2 type	0.0302	0.2058	0.2058
Schistosoma mansoni	hypothetical protein	0.0015	0.0028	0.0028
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0028	0.0029
Trichomonas vaginalis	penicillin-binding protein, putative	0.0037	0.0177	0.0282
Entamoeba histolytica	hypothetical protein	0.0037	0.0183	1
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0028	0.0029
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0028	0.0029
Giardia lamblia	Protein 21.1	0.0015	0.0028	1
Trypanosoma cruzi	Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative	0.0015	0.0028	0.0088
Trypanosoma brucei	Ankyrin repeats (3 copies)/Zinc finger, C3HC4 type (RING finger), putative	0.0015	0.0028	0.0088
Loa Loa (eye worm)	beta-lactamase	0.0037	0.0177	0.0299
Brugia malayi	Pre-SET motif family protein	0.0032	0.0142	0.024
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0177	0.0299
Leishmania major	hypothetical protein, conserved	0.0015	0.0027	0.0087
Schistosoma mansoni	hypothetical protein	0.0016	0.0029	0.003
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.004	0.0199	0.0336
Schistosoma mansoni	ring finger protein 151	0.0015	0.0028	0.0028
Brugia malayi	RING zinc finger protein	0.0015	0.0028	0.0047
Leishmania major	hypothetical protein, conserved	0.0015	0.0028	0.0088
Loa Loa (eye worm)	Smad1	0.0025	0.0093	0.0157
Schistosoma mansoni	cpg binding protein	0.0057	0.0324	0.0325
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.004	0.0199	0.0336
Brugia malayi	isocitrate dehydrogenase	0.0016	0.0032	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0421	0.071
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.0177	0.0178
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0028	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0302	0.2058	0.3469
Trypanosoma cruzi	hypothetical protein	0.0015	0.0028	0.0088
Schistosoma mansoni	brg-1 associated factor	0.0849	0.5931	0.596
Trypanosoma cruzi	Zinc finger, C3HC4 type (RING finger), putative	0.0015	0.0028	0.0088
Loa Loa (eye worm)	cytochrome P450 family protein	0.0013	0.001	0.0016
Toxoplasma gondii	SWIB/MDM2 domain-containing protein	0.0849	0.5931	1
Trichomonas vaginalis	conserved hypothetical protein	0.0849	0.5931	1
Schistosoma mansoni	hypothetical protein	0.0849	0.5931	0.596
Trypanosoma cruzi	hypothetical protein, conserved	0.0015	0.0028	0.0088
Plasmodium vivax	hypothetical protein, conserved	0.0037	0.0177	0.0254
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0015	0.0028	0.0088
Plasmodium vivax	hypothetical protein, conserved	0.0849	0.5931	1
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0028	0.0029
Brugia malayi	Zinc finger protein 183 homolog	0.0015	0.0028	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0302	0.2058	0.3469
Echinococcus multilocularis	Zinc finger, RanBP2 type	0.0302	0.2058	0.2058
Mycobacterium tuberculosis	Conserved protein	0.0037	0.0177	0.0943
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.0158	0.0266
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0037	0.0177	0.0177
Echinococcus multilocularis	smad	0.0025	0.0093	0.0093
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0028	0.0029
Trypanosoma cruzi	hypothetical protein, conserved	0.0015	0.0028	0.0088
Brugia malayi	hypothetical protein	0.0151	0.0989	0.1667
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0177	0.0282
Schistosoma mansoni	hypothetical protein	0.0034	0.0158	0.0159
Echinococcus granulosus	RING finger and transmembrane domain containing protein	0.0015	0.0028	0.0028
Schistosoma mansoni	hypothetical protein	0.0814	0.5683	0.5711
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0037	0.0177	0.0943
Toxoplasma gondii	aldehyde dehydrogenase	0.0061	0.0349	0.0544
Trichomonas vaginalis	esterase, putative	0.0037	0.0177	0.0282
Echinococcus multilocularis		0.0015	0.0028	0.0028
Brugia malayi	hypothetical protein	0.0015	0.0028	0.0047
Echinococcus granulosus	GPCR family 2	0.0016	0.0029	0.0029
Giardia lamblia	Protein 21.1	0.0015	0.0028	1
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0162	0.0273
Echinococcus multilocularis	RING finger protein 185	0.0015	0.0028	0.0028
Trypanosoma brucei	hypothetical protein, conserved	0.0302	0.2058	1
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0112	0.071	0.1156
Trichomonas vaginalis	ubiquitin-protein ligase BRE1, putative	0.0015	0.0028	0.0029
Trypanosoma brucei	Zinc finger, C3HC4 type (RING finger), putative	0.0015	0.0028	0.0088
Trypanosoma cruzi	Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative	0.0015	0.0028	0.0088
Trypanosoma cruzi	WLM domain containing protein, putative	0.0302	0.2058	1
Trypanosoma cruzi	ISWI complex protein	0.0015	0.0027	0.0087
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0208	0.0351
Brugia malayi	MH1 domain containing protein	0.0025	0.0093	0.0157
Brugia malayi	MH1 domain containing protein	0.0025	0.0093	0.0157
Leishmania major	hypothetical protein, conserved	0.0015	0.0028	0.0088
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.0177	0.0178
Trichomonas vaginalis	ankyrin repeat domain protein, putative	0.0015	0.0028	0.0029
Loa Loa (eye worm)	RiNg Finger protein family member	0.0015	0.0028	0.0047
Giardia lamblia	Protein 21.1	0.0015	0.0028	1
Plasmodium falciparum	zinc finger Ran-binding domain-containing protein 2, putative	0.0302	0.2058	0.3438
Trypanosoma cruzi	hypothetical protein, conserved	0.0015	0.0028	0.0088
Onchocerca volvulus		0.0151	0.0989	0.1628
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0015	0.0028	0.0088
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0028	0.0029
Trichomonas vaginalis	penicillin-binding protein, putative	0.0037	0.0177	0.0282
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	0.0016	0.0032	0.0008
Echinococcus multilocularis	zinc finger protein Ran binding	0.0302	0.2058	0.2058
Schistosoma mansoni	cpg binding protein	0.0062	0.036	0.0362
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0028	0.0047
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0015	0.0027	0.0027
Schistosoma mansoni	serine/threonine protein kinase	0.0015	0.0028	0.0028
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0016	0.0032	0.0032
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0061	0.0349	0.2056
Echinococcus granulosus	E3 ubiquitin protein ligase LRSAM1	0.0015	0.0028	0.0028
Echinococcus multilocularis	microtubule associated protein 2	0.1417	0.9951	0.9951
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0302	0.2058	0.3469
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0016	0.0029	0.005
Trypanosoma brucei	Zinc finger, C3HC4 type (RING finger), putative	0.0015	0.0028	0.0088
Trypanosoma cruzi	Ankyrin repeats (3 copies)/Zinc finger, C3HC4 type (RING finger), putative	0.0015	0.0028	0.0088
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0032	0.0142	0.0143
Brugia malayi	MH1 domain containing protein	0.0014	0.0015	0.0025
Brugia malayi	beta-lactamase	0.0037	0.0177	0.0299
Toxoplasma gondii	DNA topoisomerase domain-containing protein	0.0849	0.5931	1
Brugia malayi	hypothetical protein	0.0015	0.0028	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0104	0.0176
Brugia malayi	brahma associated protein 60 kDa	0.0849	0.5931	1
Leishmania major	hypothetical protein, conserved	0.0015	0.0028	0.0088
Trichomonas vaginalis	ankyrin, putative	0.0015	0.0028	0.0029
Echinococcus granulosus	E3 ubiquitin protein ligase MYLIP	0.0015	0.0028	0.0028
Schistosoma mansoni	hypothetical protein	0.0302	0.2058	0.2068
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0037	0.0183	0.0183
Trypanosoma cruzi	WLM domain containing protein, putative	0.0302	0.2058	1
Echinococcus multilocularis	neuropeptide s receptor	0.0462	0.3193	0.3193
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0778	0.1312
Loa Loa (eye worm)	CYP4Cod1	0.0013	0.001	0.0016
Loa Loa (eye worm)	transcription factor SMAD2	0.0361	0.2474	0.4171
Schistosoma mansoni	peter pan-related	0.0015	0.0028	0.0028
Brugia malayi	hypothetical protein	0.0015	0.0028	0.0047
Trypanosoma brucei	Zinc finger, C3HC4 type (RING finger), putative	0.0015	0.0028	0.0088
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0177	0.0299
Brugia malayi	MH1 domain containing protein	0.0014	0.0015	0.0025
Trypanosoma brucei	ISWI complex protein	0.0015	0.0027	0.0087
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0063	0.0366	0.0366
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0016	0.0032	0.0054
Schistosoma mansoni	aldehyde dehydrogenase	0.0061	0.0349	0.035
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0061	0.0349	1
Echinococcus granulosus	E3 ubiquitin protein ligase RNF146	0.0015	0.0028	0.0028
Echinococcus multilocularis	Smad4	0.0025	0.0093	0.0093
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0177	0.0282
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0063	0.0366	0.0366
Echinococcus granulosus	microtubule associated protein 2	0.1417	0.9951	0.9951
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0012	0.0002	0.0002
Onchocerca volvulus		0.0242	0.1629	0.2713
Brugia malayi	hypothetical protein	0.0121	0.0778	0.1312
Plasmodium falciparum	SWIB/MDM2 domain-containing protein	0.0849	0.5931	1
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0061	0.0349	0.1656
Trypanosoma brucei	predicted zinc finger protein	0.0015	0.0028	0.0088
Trypanosoma cruzi	hypothetical protein, conserved	0.0015	0.0028	0.0088

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2324556

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1725382