Detailed information for compound 173012

Basic information

Technical information
  • TDR Targets ID: 173012
  • Name: (2E)-2-[(2,4-dimethoxyphenyl)methylidene]-3,4 -dihydronaphthalen-1-one
  • MW: 294.344 | Formula: C19H18O3
  • H donors: 0 H acceptors: 1 LogP: 4.03 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(OC)ccc1/C=C/1\CCc2c(C1=O)cccc2
  • InChi: 1S/C19H18O3/c1-21-16-10-9-14(18(12-16)22-2)11-15-8-7-13-5-3-4-6-17(13)19(15)20/h3-6,9-12H,7-8H2,1-2H3/b15-11+
  • InChiKey: FJDDRTSHMRZSMG-RVDMUPIBSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (2E)-2-[(2,4-dimethoxyphenyl)methylene]tetralin-1-one
  • (2E)-2-[(2,4-dimethoxyphenyl)methylene]-1-tetralinone
  • (2E)-2-(2,4-dimethoxybenzylidene)tetralin-1-one
  • 2-[(2,4-dimethoxyphenyl)methylidene]-3,4-dihydronaphthalen-1-one
  • 2-[(2,4-dimethoxyphenyl)methylene]tetralin-1-one
  • 2-[(2,4-dimethoxyphenyl)methylene]-1-tetralinone
  • 2-(2,4-dimethoxybenzylidene)tetralin-1-one
  • T0518-4106
  • ZINC00214611
  • AI-211/12452016

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0025 0.0038
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0025 0.0046
Schistosoma mansoni smad 0.0025 0.0058 0.0068
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0027 0.5
Giardia lamblia Protein 21.1 0.0018 0.0025 0.0001
Onchocerca volvulus 0.0356 0.1614 0.3438
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0025 0.0038
Entamoeba histolytica hypothetical protein 0.0036 0.0111 1
Leishmania major DNA repair protein-like protein 0.0018 0.0025 0.0038
Trypanosoma brucei DNA repair protein, putative 0.0018 0.0025 0.0038
Echinococcus granulosus E3 ubiquitin protein ligase mib1 0.0018 0.0025 0.0025
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.012 0.0943
Trypanosoma cruzi cytochrome P450, putative 0.0026 0.0061 0.0262
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.012 0.0251
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0025 0.0038
Echinococcus granulosus ring finger protein 170 0.0018 0.0025 0.0025
Schistosoma mansoni hypothetical protein 0.0069 0.0267 0.0381
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0025 0.0046
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0027 0.0017
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.012 0.0943
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0023 0.0046 0.0046
Schistosoma mansoni hypothetical protein 0.0036 0.0111 0.0148
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.085 0.3938 0.3938
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.006 0.0089
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0018 0.0025 0.0046
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.1001 0.4647 0.4647
Onchocerca volvulus 0.0038 0.012 0.0206
Echinococcus multilocularis survival motor neuron protein 1 0.0236 0.1052 0.1052
Leishmania major hypothetical protein, conserved 0.0018 0.0025 0.0038
Mycobacterium leprae conserved hypothetical protein 0.0038 0.012 0.5
Leishmania major hypothetical protein, conserved 0.0356 0.1614 1
Echinococcus granulosus lamin dm0 0.0026 0.0064 0.0064
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0025 0.0046
Schistosoma mansoni hypothetical protein 0.0356 0.1614 0.2402
Echinococcus granulosus GPCR family 2 0.0032 0.0091 0.0091
Loa Loa (eye worm) RING finger protein 20 0.0018 0.0025 0.0054
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0064 0.0239 0.1381
Brugia malayi beta-lactamase family protein 0.0038 0.012 0.0247
Brugia malayi RING zinc finger protein 0.0018 0.0025 0.0043
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0091 0.0091
Trypanosoma cruzi hypothetical protein, conserved 0.0356 0.1614 1
Giardia lamblia Protein 21.1 0.0018 0.0025 0.0001
Echinococcus granulosus Upstream activation factor subunit UAF30 0.1001 0.4647 0.4647
Echinococcus granulosus microtubule associated protein 2 0.1433 0.6681 0.6681
Echinococcus multilocularis geminin 0.0178 0.0775 0.0775
Toxoplasma gondii zinc finger, C3HC4 type (RING finger) domain-containing protein 0.0018 0.0025 0.0013
Schistosoma mansoni hypothetical protein 0.0854 0.3955 0.5912
Leishmania major hypothetical protein, conserved 0.0018 0.0025 0.0038
Loa Loa (eye worm) hypothetical protein 0.0038 0.012 0.0258
Toxoplasma gondii ran binding protein 0.0356 0.1614 0.3447
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0019 0.0019
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0025 0.0038
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0078 0.0308 0.0652
Schistosoma mansoni lamin 0.0026 0.0064 0.0078
Leishmania major hypothetical protein, conserved 0.0018 0.0025 0.0038
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0025 0.0058 0.0068
Echinococcus multilocularis ring finger protein 170 0.0018 0.0025 0.0025
Schistosoma mansoni hypothetical protein 0.1001 0.4647 0.695
Brugia malayi Neuralized family protein 0.0018 0.0025 0.0043
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0017 0.0021 0.0012
Brugia malayi Zinc finger, C2H2 type family protein 0.0018 0.0025 0.0043
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0025 0.0038
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0015 0.0013 0.0019
Trypanosoma cruzi WLM domain containing protein, putative 0.0356 0.1614 1
Giardia lamblia Protein 21.1 0.0018 0.0025 0.0001
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0027 0.0049
Loa Loa (eye worm) hypothetical protein 0.0018 0.0025 0.0054
Echinococcus multilocularis RING finger and transmembrane domain containing protein 0.0018 0.0025 0.0025
Schistosoma mansoni hypothetical protein 0.0032 0.0091 0.0118
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0025 0.0046
Trypanosoma brucei Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0356 0.1614 1
Brugia malayi hypothetical protein 0.0018 0.0025 0.0043
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0091 0.0185
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0025 0.0046
Mycobacterium ulcerans hypothetical protein 0.0038 0.012 0.4392
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0007 0.0014
Loa Loa (eye worm) hypothetical protein 0.0018 0.0025 0.0054
Loa Loa (eye worm) hypothetical protein 0.0356 0.1614 0.3474
Loa Loa (eye worm) Smad1 0.0025 0.0058 0.0125
Echinococcus multilocularis Zinc finger, RanBP2 type 0.0356 0.1614 0.1614
Giardia lamblia Protein 21.1 0.0018 0.0025 0.0001
Onchocerca volvulus 0.0356 0.1614 0.3438
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0239 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0013 0.0027
Loa Loa (eye worm) hypothetical protein 0.0038 0.012 0.0258
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0025 0.0046
Trypanosoma cruzi WLM domain containing protein, putative 0.0356 0.1614 1
Leishmania major hypothetical protein, conserved 0.0356 0.1614 1
Brugia malayi YY1-associated factor 2 0.0356 0.1614 0.3466
Trypanosoma brucei Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0025 0.0038
Brugia malayi hypothetical protein 0.0026 0.006 0.0118
Leishmania major hypothetical protein, conserved 0.0018 0.0025 0.0038
Mycobacterium ulcerans lipase LipD 0.0038 0.012 0.4392
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0356 0.1614 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0021 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0068 0.0259 0.0558
Toxoplasma gondii zinc finger, C3HC4 type (RING finger) domain-containing protein 0.0018 0.0025 0.0013
Giardia lamblia Protein 21.1 0.0018 0.0025 0.0001
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0078 0.0308 0.0308
Echinococcus granulosus intermediate filament protein 0.0026 0.0064 0.0064
Echinococcus multilocularis SWI:SNF matrix associated 0.1001 0.4647 0.4647
Trichomonas vaginalis sex-determining protein fem-1, putative 0.0018 0.0025 0.0046
Echinococcus granulosus TGF beta signal transducer SmadC 0.0025 0.0058 0.0058
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0025 0.0038
Trichomonas vaginalis ubiquitin-protein ligase BRE1, putative 0.0018 0.0025 0.0046
Loa Loa (eye worm) brahma associated protein 0.1001 0.4647 1
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.0239 0.034
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0091 0.0091
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0025 0.0046
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0062 0.0233 0.0233
Echinococcus granulosus voltage gated potassium channel 0.0023 0.0046 0.0046
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0025 0.0046
Schistosoma mansoni ap endonuclease 0.0018 0.0027 0.0021
Echinococcus granulosus E3 ubiquitin protein ligase Bre1 0.0018 0.0025 0.0025
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0025 0.0046
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0019 0.0019
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0233 0.0331
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0025 0.0046
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.006 0.0257
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0019 0.003
Toxoplasma gondii aldehyde dehydrogenase 0.0064 0.0239 0.0476
Toxoplasma gondii SWI2/SNF2-containing protein RAD5 0.0018 0.0025 0.0013
Schistosoma mansoni brg-1 associated factor 0.1001 0.4647 0.695
Plasmodium vivax hypothetical protein, conserved 0.1001 0.4647 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0062 0.0233 0.0233
Brugia malayi hypothetical protein 0.0018 0.0025 0.0043
Loa Loa (eye worm) hypothetical protein 0.0356 0.1614 0.3474
Schistosoma mansoni lamin 0.0026 0.0064 0.0078
Trichomonas vaginalis ubiquitin-protein ligase BRE1, putative 0.0018 0.0025 0.0046
Plasmodium falciparum E3 ubiquitin-protein ligase RNF5, putative 0.0018 0.0025 0.0013
Schistosoma mansoni hypothetical protein 0.0178 0.0775 0.1144
Echinococcus granulosus hyperpolarization activated cyclic 0.0015 0.0013 0.0013
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0025 0.0038
Loa Loa (eye worm) CYP4Cod1 0.0026 0.0061 0.0131
Plasmodium falciparum zinc finger Ran-binding domain-containing protein 2, putative 0.0356 0.1614 0.3447
Echinococcus multilocularis lamin 0.0026 0.0064 0.0064
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0025 0.0046
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0025 0.0038
Loa Loa (eye worm) nuclear factor I 0.0014 0.0005 0.0011
Brugia malayi MH2 domain containing protein 0.0369 0.1675 0.3597
Entamoeba histolytica hypothetical protein 0.0036 0.0111 1
Onchocerca volvulus Huntingtin homolog 0.0127 0.0538 0.1111
Onchocerca volvulus 0.0026 0.0064 0.0085
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0064 0.0239 0.0239
Loa Loa (eye worm) hypothetical protein 0.0236 0.1052 0.2263
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0025 0.0046
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0025 0.0038
Trypanosoma cruzi Ankyrin repeats (3 copies)/Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0025 0.0038
Trichomonas vaginalis ubiquitin-protein ligase BRE1, putative 0.0018 0.0025 0.0046
Leishmania major hypothetical protein, conserved 0.0018 0.0025 0.0038
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0019 0.0019
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0027 0.0049
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0111 0.0111
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0019 0.0019
Schistosoma mansoni inhibitor of apoptosis 1 diap1 0.0018 0.0025 0.0019
Toxoplasma gondii Zn-finger in Ran binding protein and others domain-containing protein 0.0356 0.1614 0.3447
Brugia malayi Zinc finger protein 183 homolog 0.0018 0.0025 0.0043
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.006 0.0089
Echinococcus multilocularis cpg binding protein 0.0063 0.0238 0.0238
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger)/EF-hand domain pair, putative 0.0018 0.0025 0.0038
Loa Loa (eye worm) hypothetical protein 0.0018 0.0026 0.0056
Loa Loa (eye worm) CXXC zinc finger family protein 0.006 0.0222 0.0477
Schistosoma mansoni hypothetical protein 0.0032 0.0091 0.0118
Toxoplasma gondii helicase, putative 0.0018 0.0025 0.0013
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0091 0.0196
Schistosoma mansoni cpg binding protein 0.0063 0.0238 0.0338
Schistosoma mansoni cpg binding protein 0.0063 0.0238 0.0338
Trypanosoma cruzi cytochrome P450, putative 0.0026 0.0061 0.0262
Echinococcus multilocularis Nuclear pore complex protein Nup153 0.0356 0.1614 0.1614
Echinococcus multilocularis ring finger protein 113a 0.0018 0.0025 0.0025
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.012 0.0251
Trypanosoma brucei mitochondrial RNA binding complex 1 subunit 0.0356 0.1614 1
Brugia malayi hypothetical protein 0.0309 0.1395 0.2995
Trypanosoma brucei cytochrome P450, putative 0.0026 0.0061 0.0262
Echinococcus granulosus RING finger protein 185 0.0018 0.0025 0.0025
Echinococcus granulosus RING finger and transmembrane domain containing protein 0.0018 0.0025 0.0025
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0027 0.0027
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0061 0.0131
Brugia malayi CXXC zinc finger family protein 0.006 0.0222 0.0467
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0064 0.0127
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0027 0.0049
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0025 0.0038
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0023 0.0046 0.0089
Echinococcus granulosus smad 0.0025 0.0058 0.0058
Loa Loa (eye worm) histone methyltransferase 0.0021 0.0038 0.0081
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0027 0.019
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.006 0.0257
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.012 0.0251
Chlamydia trachomatis DNA topoisomerase I 0.1001 0.4647 0.5
Echinococcus multilocularis E3 ubiquitin protein ligase LRSAM1 0.0018 0.0025 0.0025
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger)/EF-hand domain pair, putative 0.0018 0.0025 0.0038
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0025 0.0038
Echinococcus granulosus E3 ubiquitin protein ligase MYLIP 0.0018 0.0025 0.0025
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0091 0.0091
Brugia malayi RING finger protein 20 0.0018 0.0025 0.0043
Echinococcus granulosus Zinc finger RanBP2 type 0.0356 0.1614 0.1614
Plasmodium vivax RING zinc finger protein, putative 0.0018 0.0025 0.0013
Loa Loa (eye worm) hypothetical protein 0.0069 0.0267 0.0574
Schistosoma mansoni ap endonuclease 0.0018 0.0027 0.0021
Onchocerca volvulus 0.1001 0.4647 1
Mycobacterium leprae Probable lipase LipE 0.0038 0.012 0.5
Schistosoma mansoni voltage-gated potassium channel 0.0023 0.0046 0.0051
Trypanosoma brucei predicted zinc finger protein 0.0018 0.0025 0.0038
Echinococcus multilocularis lamin dm0 0.0026 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0032 0.0091 0.0196
Mycobacterium tuberculosis Conserved protein 0.0038 0.012 0.0943
Brugia malayi beta-lactamase 0.0038 0.012 0.0247
Schistosoma mansoni serine/threonine protein kinase 0.0018 0.0025 0.0019
Toxoplasma gondii hypothetical protein 0.0018 0.0025 0.0013
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0025 0.0038
Echinococcus multilocularis zinc finger protein Ran binding 0.0356 0.1614 0.1614
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0427 0.1949 0.4193
Onchocerca volvulus 0.0048 0.0167 0.0306
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0025 0.0038
Onchocerca volvulus Ubiquitin thioesterase ZRANB1 homolog 0.0356 0.1614 0.3438
Echinococcus granulosus neuropeptide s receptor 0.0485 0.222 0.222
Schistosoma mansoni hypothetical protein 0.0048 0.0167 0.0231
Mycobacterium tuberculosis Conserved protein 0.0038 0.012 0.0943
Brugia malayi MH2 domain containing protein 0.0025 0.0058 0.0114
Onchocerca volvulus 0.0486 0.2225 0.476
Trichomonas vaginalis ankyrin, putative 0.0018 0.0025 0.0046
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0019 0.0019
Schistosoma mansoni hypothetical protein 0.0018 0.0025 0.0019
Leishmania major hypothetical protein 0.0018 0.0025 0.0038
Echinococcus granulosus geminin 0.0178 0.0775 0.0775
Brugia malayi Cyclic-nucleotide gated cation channel 0.0015 0.0013 0.0016
Schistosoma mansoni peter pan-related 0.0018 0.0025 0.0019
Echinococcus multilocularis smad 0.0025 0.0058 0.0058
Brugia malayi hypothetical protein 0.0018 0.0025 0.0043
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0356 0.1614 1
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0025 0.0038
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0239 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.012 0.4392
Brugia malayi intermediate filament protein 0.0026 0.0064 0.0127
Loa Loa (eye worm) hypothetical protein 0.0313 0.1412 0.3039
Echinococcus granulosus neuropeptide receptor A26 0.0485 0.222 0.222
Giardia lamblia Protein 21.1 0.0018 0.0025 0.0001
Schistosoma mansoni rnf5 0.0018 0.0025 0.0019
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0025 0.0038
Onchocerca volvulus 0.0313 0.1412 0.3001
Brugia malayi brahma associated protein 60 kDa 0.1001 0.4647 1
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.012 0.0943
Loa Loa (eye worm) hypothetical protein 0.0356 0.1614 0.3474
Loa Loa (eye worm) hypothetical protein 0.0014 0.0005 0.0011
Mycobacterium ulcerans beta-lactamase 0.0038 0.012 0.4392
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0015 0.0013 0.0013
Schistosoma mansoni survival motor neuron protein 0.0048 0.0167 0.0231
Trypanosoma cruzi Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0025 0.0038
Brugia malayi hypothetical protein 0.0016 0.0017 0.0026
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0356 0.1614 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.012 0.0258
Schistosoma mansoni hypothetical protein 0.1001 0.4647 0.695
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0027 0.0049
Echinococcus multilocularis Smad4 0.0025 0.0058 0.0058
Onchocerca volvulus 0.006 0.0222 0.0426
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0025 0.0038
Echinococcus multilocularis RING finger protein 185 0.0018 0.0025 0.0025
Leishmania major hypothetical protein, conserved 0.0018 0.0025 0.0038
Giardia lamblia Protein 21.1 0.0018 0.0025 0.0001
Onchocerca volvulus 0.0356 0.1614 0.3438
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0019 0.0041
Plasmodium vivax SET domain protein, putative 0.0062 0.0233 0.0463
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.012 0.0634
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0015 0.0013 0.0027
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0027 0.0072
Trypanosoma cruzi Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0025 0.0038
Plasmodium falciparum E3 ubiquitin-protein ligase, putative 0.0018 0.0025 0.0013
Schistosoma mansoni intermediate filament proteins 0.0026 0.0064 0.0078
Brugia malayi B-box zinc finger family protein 0.0018 0.0025 0.0043
Loa Loa (eye worm) MH2 domain-containing protein 0.0025 0.0058 0.0125
Plasmodium vivax E3 ubiquitin-protein ligase RNF5, putative 0.0018 0.0025 0.0013
Toxoplasma gondii Bardet-Biedl syndrome 5, putative 0.0018 0.0025 0.0013
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.012 0.0634
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.012 0.012
Echinococcus multilocularis microtubule associated protein 2 0.1433 0.6681 0.6681
Onchocerca volvulus 0.0038 0.012 0.0206
Schistosoma mansoni Smad4 0.0025 0.0058 0.0068
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0021 0.0038 0.0038
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.012 0.0943
Trichomonas vaginalis ion channel nompc, putative 0.0018 0.0025 0.0046
Onchocerca volvulus 0.0309 0.1395 0.2965
Toxoplasma gondii ABC1 family protein 0.0038 0.012 0.0218
Plasmodium vivax hypothetical protein, conserved 0.0038 0.012 0.0218
Trypanosoma cruzi Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0025 0.0038
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0025 0.0038
Schistosoma mansoni peter pan-related 0.0018 0.0025 0.0019
Giardia lamblia Protein 21.1 0.0018 0.0025 0.0001
Echinococcus multilocularis neuropeptide receptor A26 0.0485 0.222 0.222
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.1001 0.4647 1
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0015 0.0013 0.0013
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.012 0.4392
Schistosoma mansoni hypothetical protein 0.0032 0.0091 0.0118
Schistosoma mansoni cellular tumor antigen P53 0.0313 0.1412 0.2099
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0017 0.0021 0.0021
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0064 0.0239 0.2055
Loa Loa (eye worm) hypothetical protein 0.0062 0.0233 0.0502
Schistosoma mansoni hypothetical protein 0.0018 0.0025 0.0019
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.012 0.0161
Echinococcus granulosus cpg binding protein 0.0063 0.0238 0.0238
Toxoplasma gondii hypothetical protein 0.0018 0.0025 0.0013
Trypanosoma cruzi hypothetical protein, conserved 0.0356 0.1614 1
Echinococcus multilocularis ring and YY1 binding protein 0.0356 0.1614 0.1614
Schistosoma mansoni voltage-gated potassium channel 0.0023 0.0046 0.0051
Giardia lamblia Protein 21.1 0.0018 0.0025 0.0001
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.1001 0.4647 1
Echinococcus multilocularis voltage gated potassium channel 0.0023 0.0046 0.0046
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0233 0.0331
Leishmania major hypothetical protein, conserved 0.0356 0.1614 1
Leishmania major hypothetical protein, conserved 0.0356 0.1614 1
Plasmodium vivax DNA repair protein RAD5, putative 0.0018 0.0025 0.0013
Leishmania major hypothetical protein, conserved 0.0026 0.006 0.0257
Loa Loa (eye worm) hypothetical protein 0.0026 0.006 0.0129
Echinococcus multilocularis musashi 0.0026 0.0064 0.0064
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0015 0.0013 0.0013
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0062 0.0233 0.0233
Brugia malayi Calcitonin receptor-like protein seb-1 0.0102 0.0418 0.0889
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.012 0.0943
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.012 0.0251
Toxoplasma gondii hypothetical protein 0.0018 0.0025 0.0013
Trypanosoma brucei Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0025 0.0038
Echinococcus multilocularis E3 ubiquitin protein ligase MYLIP 0.0018 0.0025 0.0025
Giardia lamblia Ser/Thr protein kinase 0.0018 0.0025 0.0001
Brugia malayi hypothetical protein 0.0018 0.0025 0.0043
Trypanosoma brucei ring finger containing protein 0.0018 0.0025 0.0038
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.012 0.012
Giardia lamblia Protein 21.1 0.0018 0.0025 0.0001
Trichomonas vaginalis ankyrin, putative 0.0018 0.0025 0.0046
Echinococcus granulosus lamin 0.0026 0.0064 0.0064
Leishmania major hypothetical protein, conserved 0.0018 0.0025 0.0038
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0356 0.1614 0.3466
Trypanosoma cruzi hypothetical protein, conserved 0.0356 0.1614 1
Schistosoma mansoni hypothetical protein 0.0032 0.0091 0.0118
Trichomonas vaginalis ankyrin repeat domain protein, putative 0.0018 0.0025 0.0046
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0017 0.0021 0.0021
Brugia malayi Hypothetical RING finger protein C16C10.7 in chromosome III 0.0018 0.0025 0.0043
Giardia lamblia Protein 21.1 0.0018 0.0025 0.0001
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0064 0.0139
Loa Loa (eye worm) hypothetical protein 0.0026 0.0062 0.0134
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0025 0.0046
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0018 0.0025 0.0046
Leishmania major hypothetical protein, conserved 0.0018 0.0025 0.0038
Brugia malayi brahma associated protein 60 kDa 0.1001 0.4647 1
Plasmodium vivax trophozoite exported protein 1, putative 0.0018 0.0025 0.0013
Giardia lamblia Protein 21.1 0.0018 0.0025 0.0001
Plasmodium falciparum RING zinc finger protein, putative 0.0018 0.0025 0.0013
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0026 0.0061 0.1601
Brugia malayi F/Y-rich N-terminus family protein 0.0021 0.0037 0.0067
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0025 0.0038
Brugia malayi hypothetical protein 0.0036 0.0111 0.0228
Echinococcus granulosus cell growth regulator with ring finger domain 0.0018 0.0025 0.0025
Schistosoma mansoni TRABID protein (C64 family) 0.0356 0.1614 0.2402
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0025 0.0038
Schistosoma mansoni zinc finger protein 0.0356 0.1614 0.2402
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0015 0.0013 0.0027
Loa Loa (eye worm) hypothetical protein 0.0018 0.0025 0.0054
Loa Loa (eye worm) hypothetical protein 0.0026 0.0064 0.0139
Echinococcus multilocularis SWI:SNF matrix associated 0.1001 0.4647 0.4647
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.006 0.0089
Loa Loa (eye worm) hypothetical protein 0.0018 0.0025 0.0054
Leishmania major hypothetical protein, conserved 0.0018 0.0025 0.0038
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0027 0.0017
Loa Loa (eye worm) hypothetical protein 0.0309 0.1395 0.3003
Trypanosoma cruzi Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0025 0.0038
Leishmania major cytochrome p450-like protein 0.0026 0.0061 0.0262
Loa Loa (eye worm) hypothetical protein 0.0018 0.0025 0.0054
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0025 0.0046
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0027 1
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0015 0.0013 0.0013
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0025 0.0046
Trypanosoma brucei hypothetical protein, conserved 0.0356 0.1614 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0046 0.01
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.0267 0.0563
Leishmania major hypothetical protein, conserved 0.0018 0.0025 0.0038
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0025 0.0046
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0102 0.0418 0.0889
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0239 1
Echinococcus granulosus dnaJ subfamily B 0.0854 0.3955 0.3955
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0007 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0025 0.0046
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0025 0.0046
Brugia malayi MH2 domain containing protein 0.0025 0.0058 0.0114
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0027 0.0046
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0025 0.0046
Onchocerca volvulus 0.0026 0.0064 0.0085
Echinococcus multilocularis GPCR, family 2 0.0032 0.0091 0.0091
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0025 0.0046
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.1001 0.4647 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0245 0.1091 1
Loa Loa (eye worm) RiNg Finger protein family member 0.0018 0.0025 0.0054
Plasmodium vivax zinc finger protein, putative 0.0018 0.0025 0.0013
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0356 0.1614 0.3466
Loa Loa (eye worm) hypothetical protein 0.0018 0.0025 0.0054
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0018 0.0025 0.0046
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0025 0.0038
Leishmania major hypothetical protein, unknown function 0.0018 0.0025 0.0038
Leishmania major hypothetical protein, conserved 0.0018 0.0025 0.0038
Onchocerca volvulus 0.0062 0.0233 0.045
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0073 0.0284 0.0603
Trypanosoma brucei SNF2 family N-terminal domain/Ring finger domain containing protein, putative 0.0018 0.0025 0.0038
Echinococcus granulosus mothers against decapentaplegic 5 0.0025 0.0058 0.0058
Echinococcus multilocularis mothers against decapentaplegic 5 0.0025 0.0058 0.0058
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0019 0.0019
Brugia malayi beta-lactamase family protein 0.0038 0.012 0.0247
Giardia lamblia Protein 21.1 0.0018 0.0025 0.0001
Brugia malayi Smad1 0.0025 0.0058 0.0114
Loa Loa (eye worm) MH1 domain-containing protein 0.0025 0.0058 0.0125
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0061 0.0131
Brugia malayi hypothetical protein 0.0018 0.0025 0.0043
Echinococcus granulosus ring and YY1 binding protein 0.0356 0.1614 0.1614
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0091 0.0185
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0025 0.0038
Giardia lamblia Protein 21.1 0.0018 0.0025 0.0001
Schistosoma mansoni smad1 5 8 and 0.0025 0.0058 0.0068
Loa Loa (eye worm) hypothetical protein 0.0018 0.0025 0.0054
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0025 0.0038
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0064 0.0239 0.0239
Loa Loa (eye worm) hypothetical protein 0.0018 0.0025 0.0054
Loa Loa (eye worm) hypothetical protein 0.0356 0.1614 0.3474
Trypanosoma brucei Ankyrin repeats (3 copies)/Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0025 0.0038
Echinococcus granulosus E3 ubiquitin protein ligase LRSAM1 0.0018 0.0025 0.0025
Giardia lamblia Protein 21.1 0.0018 0.0025 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0025 0.0046
Trypanosoma brucei hypothetical protein, conserved 0.0356 0.1614 1
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0015 0.0013 0.0013
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger) containing protein, putative 0.0018 0.0025 0.0038
Trichomonas vaginalis ankyrin 2,3/unc44, putative 0.0018 0.0025 0.0046
Brugia malayi hypothetical protein 0.0127 0.0538 0.1149
Onchocerca volvulus 0.0356 0.1614 0.3438
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.012 0.0258
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0356 0.1614 0.3466
Schistosoma mansoni mind bomb 0.0018 0.0025 0.0019
Giardia lamblia Protein 21.1 0.0018 0.0025 0.0001
Trichomonas vaginalis ankyrin, putative 0.0018 0.0025 0.0046
Trichomonas vaginalis esterase, putative 0.0038 0.012 0.0251
Loa Loa (eye worm) hypothetical protein 0.0102 0.0418 0.0899
Trichomonas vaginalis conserved hypothetical protein 0.1001 0.4647 1
Echinococcus granulosus Nuclear pore complex protein Nup153 0.0356 0.1614 0.1614
Mycobacterium tuberculosis Conserved protein 0.0038 0.012 0.0943
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0025 0.0038
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0015 0.0013 0.0019
Giardia lamblia Protein 21.1 0.0018 0.0025 0.0001
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0015 0.0013 0.0013
Loa Loa (eye worm) MH2 domain-containing protein 0.0369 0.1675 0.3604
Trichomonas vaginalis set domain proteins, putative 0.0486 0.2225 0.4784
Schistosoma mansoni fusion 0.0356 0.1614 0.2402
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0015 0.0013 0.0013
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0059 0.0217 0.0217
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0091 0.0091
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0025 0.0046
Echinococcus multilocularis SWI:SNF matrix associated 0.1001 0.4647 0.4647
Giardia lamblia Kinase, NEK 0.0018 0.0025 0.0001
Trypanosoma cruzi hypothetical protein 0.0018 0.0025 0.0038
Plasmodium falciparum zinc finger protein, putative 0.0018 0.0025 0.0013
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0017 0.0021 0.0021
Echinococcus multilocularis neuropeptide s receptor 0.0485 0.222 0.222
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0129 0.0548 0.0803
Schistosoma mansoni zinc finger protein 0.0018 0.0025 0.0019
Schistosoma mansoni voltage-gated potassium channel 0.0085 0.0342 0.0493
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0025 0.0038
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0078 0.0308 0.0308
Toxoplasma gondii histone lysine methyltransferase SET1 0.0116 0.0485 0.1006
Leishmania major hypothetical protein, conserved 0.0038 0.012 0.0634
Echinococcus multilocularis tumor protein p63 0.2139 1 1
Schistosoma mansoni hypothetical protein 0.0178 0.0775 0.1144
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0356 0.1614 1
Toxoplasma gondii exonuclease III APE 0.0018 0.0027 0.0017
Brugia malayi Cytochrome P450 family protein 0.0026 0.0061 0.012
Schistosoma mansoni hypothetical protein 0.0018 0.0025 0.0019
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.012 0.0161
Schistosoma mansoni smad1 5 8 and 0.0025 0.0058 0.0068
Echinococcus granulosus mixed lineage leukemia protein mll 0.0017 0.0021 0.0021
Echinococcus multilocularis E3 ubiquitin protein ligase mib1 0.0018 0.0025 0.0025
Onchocerca volvulus Huntingtin homolog 0.0127 0.0538 0.1111
Loa Loa (eye worm) hypothetical protein 0.0018 0.0025 0.0054
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0019 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0025 0.0046
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0078 0.0308 0.0662
Schistosoma mansoni hypothetical protein 0.1001 0.4647 0.695
Giardia lamblia Protein 21.1 0.0018 0.0025 0.0001
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0025 0.0038
Trichomonas vaginalis cell cycle control protein cwf24, putative 0.0018 0.0025 0.0046
Brugia malayi hypothetical protein 0.0236 0.1052 0.2254
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0025 0.0046
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0356 0.1614 0.3466
Giardia lamblia Protein 21.1 0.0018 0.0025 0.0001
Trypanosoma brucei UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0025 0.0038
Echinococcus granulosus Smad4 0.0025 0.0058 0.0058
Leishmania major hypothetical protein, conserved 0.0018 0.0025 0.0038
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0027 0.0049
Brugia malayi MH1 domain containing protein 0.0025 0.0058 0.0114
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.012 0.0251
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0027 0.0049
Trypanosoma cruzi Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0356 0.1614 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0102 0.0418 0.0899
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0025 0.0058 0.0058
Schistosoma mansoni voltage-gated potassium channel 0.0085 0.0342 0.0493
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0025 0.0038
Brugia malayi isocitrate dehydrogenase 0.0017 0.0019 0.003
Loa Loa (eye worm) hypothetical protein 0.0356 0.1614 0.3474
Schistosoma mansoni microtubule-associated protein tau 0.1433 0.6681 1
Schistosoma mansoni ring finger protein 151 0.0018 0.0025 0.0019
Toxoplasma gondii RING zinc finger protein 0.0018 0.0025 0.0013
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.1001 0.4647 1
Loa Loa (eye worm) beta-lactamase 0.0038 0.012 0.0258
Giardia lamblia Protein 21.1 0.0018 0.0025 0.0001
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0027 0.0027
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0025 0.0046
Entamoeba histolytica hypothetical protein 0.0036 0.0111 1
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0025 0.0046
Leishmania major hypothetical protein, conserved 0.0018 0.0025 0.0038
Loa Loa (eye worm) hypothetical protein 0.0038 0.012 0.0258
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0073 0.0284 0.0603
Onchocerca volvulus 0.0038 0.012 0.0206
Echinococcus multilocularis dnaJ subfamily B 0.0854 0.3955 0.3955
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.006 0.0257
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.012 0.0247
Echinococcus granulosus survival motor neuron protein 1 0.0236 0.1052 0.1052
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.012 0.0634
Echinococcus multilocularis E3 ubiquitin protein ligase Bre1 0.0018 0.0025 0.0025
Brugia malayi hypothetical protein 0.0018 0.0025 0.0043
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0025 0.0038
Schistosoma mansoni smad1 5 8 and 0.0025 0.0058 0.0068
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0111 0.0111
Echinococcus multilocularis hyperpolarization activated cyclic 0.0015 0.0013 0.0013
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.012 0.0943
Trypanosoma cruzi Ankyrin repeats (3 copies)/Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0025 0.0038
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0027 0.5
Echinococcus granulosus E3 ubiquitin protein ligase RNF146 0.0018 0.0025 0.0025
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0025 0.0038
Loa Loa (eye worm) hypothetical protein 0.0127 0.0538 0.1159
Echinococcus granulosus hyperpolarization activated cyclic 0.0015 0.0013 0.0013
Echinococcus granulosus zinc finger protein Ran binding 0.0356 0.1614 0.1614
Brugia malayi Cytochrome P450 family protein 0.0026 0.0061 0.012
Loa Loa (eye worm) hypothetical protein 0.0038 0.012 0.0258
Loa Loa (eye worm) hypothetical protein 0.0018 0.0025 0.0054
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0062 0.0233 0.0331
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0025 0.0038
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.006 0.0089
Echinococcus multilocularis 0.0018 0.0025 0.0025
Echinococcus multilocularis hyperpolarization activated cyclic 0.0015 0.0013 0.0013
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0025 0.0038
Brugia malayi Pre-SET motif family protein 0.0427 0.1949 0.4187
Plasmodium falciparum trophozoite exported protein 1 0.0018 0.0025 0.0013
Brugia malayi Pre-SET motif family protein 0.0062 0.0233 0.0491
Echinococcus granulosus ring finger protein 113a 0.0018 0.0025 0.0025
Entamoeba histolytica hypothetical protein 0.0036 0.0111 1
Trichomonas vaginalis hypothetical protein 0.0018 0.0025 0.0046
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.012 0.0943
Loa Loa (eye worm) hypothetical protein 0.0038 0.012 0.0258
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0023 0.0046 0.0046
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0025 0.0038
Echinococcus granulosus SWI:SNF matrix associated 0.1001 0.4647 0.4647
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0025 0.0046
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.1001 0.4647 1
Toxoplasma gondii hypothetical protein 0.0018 0.0025 0.0013
Brugia malayi MH1 domain containing protein 0.0025 0.0058 0.0114
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0233 0.0331
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0064 0.0139
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0027 0.0058
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.0239 0.034
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0062 0.0233 0.0463
Giardia lamblia Protein 21.1 0.0018 0.0025 0.0001
Loa Loa (eye worm) transcription factor SMAD2 0.0369 0.1675 0.3604
Loa Loa (eye worm) hypothetical protein 0.0127 0.0538 0.1159
Trypanosoma cruzi hypothetical protein 0.0018 0.0025 0.0038
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0025 0.0038
Plasmodium vivax E3 ubiquitin-protein ligase, putative 0.0018 0.0025 0.0013
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0167 0.0348
Brugia malayi SWIB/MDM2 domain containing protein 0.1001 0.4647 1
Chlamydia trachomatis SWIB complex protein 0.1001 0.4647 0.5
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0111 0.0148
Schistosoma mansoni cpg binding protein 0.006 0.0222 0.0314
Schistosoma mansoni RNA binding protein 0.0356 0.1614 0.2402
Leishmania major hypothetical protein, conserved 0.0356 0.1614 1
Giardia lamblia Protein 21.1 0.0018 0.0025 0.0001
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.1001 0.4647 1
Giardia lamblia Protein 21.1 0.0018 0.0025 0.0001

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 1.69 uM Inhibitory concentration against proliferation of human Molt 4/C8 cells ChEMBL. 12086496
IC50 (functional) = 1.88 uM Inhibitory concentration against CEM T-lymphocytes ChEMBL. 12086496
IC50 (functional) = 1.88 uM Inhibitory concentration against CEM T-lymphocytes ChEMBL. 12086496
IC50 (functional) = 2.61 uM Inhibitory activity against Murine P388 cells ChEMBL. 12086496
IC50 (functional) = 2.61 uM Inhibitory activity against Murine P388 cells ChEMBL. 12086496
IC50 (functional) = 7.98 uM Inhibitory activity against L1210 leukemia cells ChEMBL. 12086496
IC50 (functional) = 7.98 uM Inhibitory activity against L1210 leukemia cells ChEMBL. 12086496

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Mus musculus ChEMBL23 12086496
Homo sapiens ChEMBL23 12086496

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.