Detailed information for compound 1759516

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 386.486 | Formula: C25H26N2O2
  • H donors: 1 H acceptors: 1 LogP: 4.13 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1[C@@H](NC/C=C\C[C@@H](N1Cc1ccccc1)c1ccco1)Cc1ccccc1
  • InChi: 1S/C25H26N2O2/c28-25-22(18-20-10-3-1-4-11-20)26-16-8-7-14-23(24-15-9-17-29-24)27(25)19-21-12-5-2-6-13-21/h1-13,15,17,22-23,26H,14,16,18-19H2/b8-7-/t22-,23+/m0/s1
  • InChiKey: FEOKNKSGMNNDFL-AHSWYQDFSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax hypothetical protein, conserved 0.0592 0.0726 0.5561
Echinococcus multilocularis protein dispatched 1 0.0053 0.0033 0.0149
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0425 0.0512 0.0285
Brugia malayi AMP-binding enzyme family protein 0.1271 0.1598 0.1598
Echinococcus multilocularis snurportin 1 0.0372 0.0443 0.2832
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0112 0.0109 0.0646
Loa Loa (eye worm) hypothetical protein 0.0207 0.0232 0.025
Loa Loa (eye worm) phosphopantetheine attachment site family protein 0.0417 0.0502 0.0555
Schistosoma mansoni carbonic anhydrase-related 0.011 0.0107 0.0623
Trypanosoma brucei Trans-2-enoyl-ACP reductase 2, putative 0.0257 0.0295 0.2213
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.4371 0.558 0.6973
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0112 0.0109 0.0646
Schistosoma mansoni hypothetical protein 0.0044 0.0023 0.0079
Mycobacterium tuberculosis Possible oxidoreductase FadB5 0.0257 0.0295 0.0173
Trypanosoma cruzi oxidoreductase, putative 0.0257 0.0295 0.2264
Mycobacterium ulcerans zinc-dependent alcohol dehydrogenase 0.0257 0.0295 0.0083
Toxoplasma gondii Zn-containing alcohol dehydrogenase 0.0257 0.0295 0.0511
Loa Loa (eye worm) carboxylesterase 0.1224 0.1538 0.1727
Mycobacterium tuberculosis Possible dehydrogenase 0.0257 0.0295 0.0173
Echinococcus granulosus Niemann Pick C1 protein 0.0107 0.0104 0.0609
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.4371 0.558 0.7025
Mycobacterium ulcerans acyl-CoA synthetase 0.0425 0.0512 0.0366
Mycobacterium ulcerans non-ribosomal peptide synthetase 0.0418 0.0503 0.0355
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0257 0.0295 0.1878
Schistosoma mansoni hypothetical protein 0.0372 0.0443 0.2786
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.011 0.0107 0.0107
Mycobacterium ulcerans zinc-containing alcohol dehydrogenase NAD dependent AdhB 0.0257 0.0295 0.0083
Plasmodium falciparum carbonic anhydrase 0.011 0.0107 0.0752
Mycobacterium ulcerans 3-oxoacyl-(acyl carrier protein) synthase II 0.1037 0.1297 0.1394
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0203 0.0227 0.0245
Trypanosoma cruzi oxidoreductase, putative 0.0257 0.0295 0.2264
Mycobacterium ulcerans polyketide synthase Pks9 0.2716 0.3454 0.4216
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0207 0.0232 0.1446
Mycobacterium tuberculosis Polyketide synthase Pks13 0.6158 0.7874 1
Schistosoma mansoni [ACP] S-malonyltransferase 0.0261 0.0301 0.1868
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0425 0.0512 0.0366
Toxoplasma gondii acyl transferase domain-containing protein 0.0261 0.0301 0.0521
Mycobacterium tuberculosis Probable NADPH quinone oxidoreductase FadB4 (NADPH:quinone reductase) (zeta-crystallin) 0.0257 0.0295 0.0173
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.4004 0.5108 0.6413
Plasmodium vivax acyl carrier protein, putative 0.0417 0.0502 0.3816
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.1037 0.1297 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0257 0.0295 0.0173
Brugia malayi Carboxylesterase family protein 0.0207 0.0232 0.0232
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0035 0.0012 0.0001
Leishmania major quinone oxidoreductase, putative 0.0257 0.0295 0.1878
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0112 0.0109 0.0635
Chlamydia trachomatis acyl carrier protein 0.0417 0.0502 0.2016
Schistosoma mansoni BC026374 protein (S09 family) 0.0207 0.0232 0.1423
Toxoplasma gondii quinone oxidoreductase, putative 0.0257 0.0295 0.0511
Loa Loa (eye worm) hypothetical protein 0.0106 0.0103 0.0104
Mycobacterium ulcerans oxidoreductase FadB5 0.0257 0.0295 0.0083
Entamoeba histolytica acyl-CoA synthetase, putative 0.0418 0.0503 0.9403
Loa Loa (eye worm) hypothetical protein 0.0257 0.0295 0.0322
Echinococcus multilocularis 3 oxoacyl (acyl carrier protein) synthase 0.1037 0.1297 0.8422
Loa Loa (eye worm) hypothetical protein 0.6924 0.8858 1
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0425 0.0512 0.0453
Trypanosoma brucei beta-ketoacyl-ACP synthase 0.1037 0.1297 1
Toxoplasma gondii LsmAD domain-containing protein 0.0041 0.0019 0.0014
Echinococcus granulosus Malonyl coenzyme A acyl carrier protein transacylase 0.0261 0.0301 0.1899
Leishmania major carbonic anhydrase-like protein 0.0203 0.0227 0.144
Mycobacterium ulcerans fatty acid synthase Fas 0.1297 0.1632 0.1833
Loa Loa (eye worm) hypothetical protein 0.0634 0.078 0.0869
Schistosoma mansoni carbonic anhydrase-related 0.011 0.0107 0.0623
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.4371 0.558 0.6998
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.4371 0.558 0.6998
Schistosoma mansoni carbonic anhydrase-related 0.011 0.0107 0.0623
Loa Loa (eye worm) hypothetical protein 0.0207 0.0232 0.025
Loa Loa (eye worm) beta-ketoacyl synthase domain-containing protein 0.1037 0.1297 0.1454
Giardia lamblia Methyltransferase like 2 0.1244 0.1564 0.5
Loa Loa (eye worm) hypothetical protein 0.011 0.0107 0.0109
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0418 0.0503 0.0442
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0046 0.0025 0.0016
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.4371 0.558 0.6973
Loa Loa (eye worm) alcohol dehydrogenase class III 0.0257 0.0295 0.0322
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.4115 0.525 0.6538
Trypanosoma cruzi PAB1-binding protein , putative 0.0041 0.0019 0.0127
Brugia malayi Phosphopantetheine attachment site family protein 0.0417 0.0502 0.0502
Loa Loa (eye worm) hypothetical protein 0.0257 0.0295 0.0322
Brugia malayi Alcohol dehydrogenase class III 0.0257 0.0295 0.0295
Echinococcus multilocularis mitochondrial trans 2 enoyl coenzyme A reductase 0.0257 0.0295 0.1864
Schistosoma mansoni acyl carrier protein 0.0417 0.0502 0.3162
Mycobacterium ulcerans quinone reductase Qor 0.0257 0.0295 0.0083
Schistosoma mansoni zinc binding dehydrogenase 0.0257 0.0295 0.1833
Mycobacterium tuberculosis Probable acyl carrier protein AcpA (ACP) 0.0417 0.0502 0.044
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0257 0.0295 0.0295
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.1037 0.1297 1
Echinococcus multilocularis expressed conserved protein 0.0101 0.0095 0.0555
Onchocerca volvulus 0.7196 0.9208 0.9656
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0634 0.078 0.0801
Echinococcus granulosus 3 oxoacyl acyl carrier protein synthase 0.1037 0.1297 0.8422
Brugia malayi hypothetical protein 0.0207 0.0232 0.0232
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.4115 0.525 0.6538
Loa Loa (eye worm) hypothetical protein 0.0261 0.0301 0.0328
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0203 0.0227 0.1736
Mycobacterium tuberculosis Probable thioesterase TesA 0.3442 0.4386 0.5477
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0203 0.0227 0.1393
Echinococcus granulosus AMP dependent ligase 0.0418 0.0503 0.3223
Plasmodium falciparum ataxin-2 like protein, putative 0.0041 0.0019 0.0062
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.6158 0.7874 1
Loa Loa (eye worm) acetylcholinesterase 1 0.1224 0.1538 0.1727
Mycobacterium ulcerans hypothetical protein 0.0417 0.0502 0.0353
Mycobacterium tuberculosis S-nitrosomycothiol reductase MscR 0.0257 0.0295 0.0173
Mycobacterium tuberculosis Conserved hypothetical protein 0.0417 0.0502 0.044
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0257 0.0295 0.1878
Mycobacterium ulcerans oxidoreductase 0.0257 0.0295 0.0083
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0035 0.0012 0.0012
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.2679 0.3407 0.6097
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0257 0.0295 0.0295
Echinococcus granulosus tachykinin peptides receptor 99D 0.0338 0.0401 0.2552
Mycobacterium tuberculosis Hypothetical protein 0.1244 0.1564 0.1818
Brugia malayi Carboxylesterase family protein 0.0207 0.0232 0.0232
Echinococcus multilocularis Acyl carrier protein, mitochondrial 0.0417 0.0502 0.3214
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.3442 0.4386 0.5398
Loa Loa (eye worm) acyl carrier protein 0.0417 0.0502 0.0555
Onchocerca volvulus 0.0257 0.0295 0.0069
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.4371 0.558 0.7025
Schistosoma mansoni carbonic anhydrase 0.011 0.0107 0.0623
Onchocerca volvulus Acyl carrier protein, mitochondrial homolog 0.0417 0.0502 0.0291
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0112 0.0109 0.0111
Echinococcus multilocularis muscleblind protein 1 0.0106 0.0103 0.0601
Trichomonas vaginalis conserved hypothetical protein 0.1244 0.1564 1
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.4115 0.525 0.525
Loa Loa (eye worm) acyl carrier protein 0.1899 0.2405 0.2706
Toxoplasma gondii hypothetical protein 0.011 0.0107 0.0174
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0425 0.0512 0.0453
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.3308 0.4214 0.5211
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.1037 0.1297 0.1297
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.2716 0.3454 0.4168
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.011 0.0107 0.0107
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0634 0.078 0.0801
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 0.0418 0.0503 0.0355
Echinococcus multilocularis neuroligin 0.0207 0.0232 0.1446
Plasmodium falciparum ataxin-2 like protein, putative 0.0041 0.0019 0.0062
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0109 0.0106 0.0613
Brugia malayi Carboxylesterase family protein 0.0207 0.0232 0.0232
Entamoeba histolytica NADP-dependent alcohol dehydrogenase, putative 0.0257 0.0295 0.5504
Echinococcus multilocularis geminin 0.0205 0.0229 0.1428
Brugia malayi hypothetical protein 0.0041 0.0019 0.0019
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0207 0.0232 0.1423
Brugia malayi CHE-14 protein 0.0046 0.0025 0.0025
Mycobacterium tuberculosis Probable NADP-dependent alcohol dehydrogenase AdhC 0.0257 0.0295 0.0173
Schistosoma mansoni hypothetical protein 0.0417 0.0502 0.3162
Toxoplasma gondii 3-oxoacyl-acyl-carrier protein synthase I/II, putative 0.1037 0.1297 0.231
Mycobacterium ulcerans zinc-dependent alcohol dehydrogenase AdhE2 0.0257 0.0295 0.0083
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.011 0.0107 0.0109
Echinococcus granulosus mitochondrial trans 2 enoyl coenzyme A reductase 0.0257 0.0295 0.1864
Mycobacterium tuberculosis Possible quinone oxidoreductase (NADPH:quinone oxidoreductase) (zeta-crystallin) 0.0257 0.0295 0.0173
Mycobacterium ulcerans malonyl CoA-acyl carrier protein transacylase FabD 0.0261 0.0301 0.009
Entamoeba histolytica NADP-dependent alcohol dehydrogenase, putative 0.0257 0.0295 0.5504
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.2967 0.3776 0.4687
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.1037 0.1297 1
Mycobacterium ulcerans NADPH quinone oxidoreductase FadB4 0.0257 0.0295 0.0083
Onchocerca volvulus Putative alcohol dehydrogenase 0.0257 0.0295 0.0069
Entamoeba histolytica acyl-CoA synthetase, putative 0.0443 0.0535 1
Treponema pallidum acyl carrier protein 0.0417 0.0502 0.5
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.011 0.0107 0.0107
Plasmodium vivax ataxin-2 like protein, putative 0.0041 0.0019 0.0062
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0592 0.0726 0.5561
Mycobacterium ulcerans short-chain dehydrogenase 0.0257 0.0295 0.0083
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0425 0.0512 0.0366
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0338 0.0401 0.2552
Brugia malayi acyl carrier protein, mitochondrial precursor, putative 0.0417 0.0502 0.0502
Echinococcus multilocularis BC026374 protein (S09 family) 0.0207 0.0232 0.1446
Schistosoma mansoni patched 1 0.0046 0.0025 0.0093
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.4115 0.525 0.6598
Loa Loa (eye worm) hypothetical protein 0.0634 0.078 0.0869
Plasmodium falciparum acyl carrier protein 0.0417 0.0502 0.3816
Echinococcus multilocularis carboxylesterase 5A 0.1224 0.1538 1
Leishmania major oxidoreductase-like protein 0.0257 0.0295 0.1878
Mycobacterium ulcerans Type I modular polyketide synthase 0.4115 0.525 0.6567
Leishmania major oxidoreductase, putative 0.0257 0.0295 0.1878
Onchocerca volvulus 0.0425 0.0512 0.0301
Trypanosoma cruzi acyl transferase-like protein 0.0261 0.0301 0.2305
Brugia malayi Carboxylesterase family protein 0.1224 0.1538 0.1538
Mycobacterium ulcerans Type I modular polyketide synthase 0.4115 0.525 0.6567
Loa Loa (eye worm) hypothetical protein 0.2299 0.2918 0.3286
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0418 0.0503 0.0274
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.3362 0.4284 0.5345
Loa Loa (eye worm) carboxylesterase 0.0207 0.0232 0.025
Echinococcus granulosus acetylcholinesterase 0.1224 0.1538 1
Echinococcus granulosus expressed conserved protein 0.0101 0.0095 0.0555
Echinococcus granulosus carboxylesterase 5A 0.1224 0.1538 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.1224 0.1538 0.9836
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.4115 0.525 0.6598
Brugia malayi ADP-specific Phosphofructokinase/Glucokinase conserved region family protein 0.0261 0.0301 0.0301
Brugia malayi Calcitonin receptor-like protein seb-1 0.0035 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.011 0.0107 0.0109
Mycobacterium leprae conserved hypothetical protein 0.0417 0.0502 0.0272
Loa Loa (eye worm) hypothetical protein 0.0207 0.0232 0.025
Mycobacterium ulcerans quinone oxidoreductase 0.0257 0.0295 0.0083
Schistosoma mansoni hypothetical protein 0.011 0.0107 0.0623
Mycobacterium ulcerans NADP-dependent alcohol dehydrogenase Adh 0.0257 0.0295 0.0083
Trichomonas vaginalis spcc417.12 protein, putative 0.0207 0.0232 0.1469
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0203 0.0227 0.0227
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.3866 0.4932 0.6185
Echinococcus multilocularis protein patched 0.0046 0.0025 0.0094
Schistosoma mansoni 3-oxoacyl-[ACP] synthase 0.1037 0.1297 0.8284
Echinococcus granulosus sterol regulatory element binding protein 0.0046 0.0025 0.0094
Loa Loa (eye worm) hypothetical protein 0.1224 0.1538 0.1727
Leishmania major hypothetical protein, conserved 0.1244 0.1564 1
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.2716 0.3454 0.4216
Echinococcus multilocularis Niemann Pick C1 protein 0.0107 0.0104 0.0609
Mycobacterium tuberculosis Polyketide synthase Pks12 0.4371 0.558 0.7025
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.2088 0.2648 0.4734
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0425 0.0512 0.0453
Leishmania major zinc binding dehydrogenase-like protein 0.0257 0.0295 0.1878
Leishmania major hypothetical protein, conserved 0.0041 0.0019 0.0105
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0425 0.0512 0.0366
Loa Loa (eye worm) hypothetical protein 0.0056 0.0038 0.0031
Trypanosoma cruzi nuclear receptor binding factor, putative 0.0257 0.0295 0.2264
Brugia malayi Niemann-Pick C1 protein precursor 0.0107 0.0104 0.0104
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0203 0.0227 0.0227
Mycobacterium ulcerans zinc-containing alcohol dehydrogenase NAD-dependent AdhB 0.0257 0.0295 0.0083
Loa Loa (eye worm) hypothetical protein 0.0041 0.0019 0.0009
Echinococcus multilocularis para nitrobenzyl esterase 0.0207 0.0232 0.1446
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0025 0.0146
Wolbachia endosymbiont of Brugia malayi ACP S-malonyltransferase 0.0261 0.0301 0.0053
Echinococcus granulosus geminin 0.0205 0.0229 0.1428
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0112 0.0109 0.0646
Mycobacterium ulcerans quinone oxidoreductase 0.0257 0.0295 0.0083
Loa Loa (eye worm) hypothetical protein 0.0035 0.0012 0.0001
Echinococcus granulosus carbonic anhydrase II 0.0203 0.0227 0.1417
Loa Loa (eye worm) AMP-binding enzyme family protein 0.3866 0.4932 0.5562
Schistosoma mansoni hypothetical protein 0.0205 0.0229 0.1404
Mycobacterium tuberculosis Polyketide synthetase MbtD (polyketide synthase) 0.127 0.1597 0.186
Schistosoma mansoni hypothetical protein 0.0044 0.0023 0.0079
Trypanosoma cruzi Acyl carrier protein, mitochondrial, putative 0.0417 0.0502 0.3857
Echinococcus multilocularis acetylcholinesterase 0.1224 0.1538 1
Schistosoma mansoni [ACP] S-malonyltransferase 0.0261 0.0301 0.1868
Leishmania major acyl carrier protein, putative 0.0417 0.0502 0.3199
Echinococcus granulosus carbonic anhydrase 0.011 0.0107 0.0633
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0203 0.0227 0.1393
Leishmania major nuclear receptor binding factor-like protein 0.0257 0.0295 0.1878
Echinococcus multilocularis Niemann Pick C1 protein 0.0153 0.0163 0.0996
Echinococcus granulosus carbonic anhydrase 0.011 0.0107 0.0633
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.1404 0.177 0.2084
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0425 0.0512 0.0453
Trypanosoma cruzi nuclear receptor binding factor, putative 0.0257 0.0295 0.2264
Loa Loa (eye worm) carbonic anhydrase 3 0.0203 0.0227 0.0245
Mycobacterium tuberculosis Carboxylesterase LipT 0.0207 0.0232 0.009
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0207 0.0232 0.1469
Onchocerca volvulus Fatty acid synthase homolog 0.7445 0.9528 1
Echinococcus multilocularis carbonic anhydrase II 0.0203 0.0227 0.1417
Mycobacterium ulcerans acyl carrier protein 0.0417 0.0502 0.0353
Trypanosoma brucei oxidoreductase, putative 0.0257 0.0295 0.2213
Echinococcus multilocularis AMP dependent ligase 0.0418 0.0503 0.3223
Mycobacterium tuberculosis Probable zinc-type alcohol dehydrogenase AdhD (aldehyde reductase) 0.0257 0.0295 0.0173
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0112 0.0109 0.0635
Loa Loa (eye worm) hypothetical protein 0.0257 0.0295 0.0322
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.4115 0.525 0.6598
Echinococcus granulosus carbonic anhydrase 0.011 0.0107 0.0633
Brugia malayi Muscleblind-like protein 0.0106 0.0103 0.0103
Schistosoma mansoni gliotactin 0.0207 0.0232 0.1423
Echinococcus granulosus neuroligin 0.0207 0.0232 0.1446
Mycobacterium ulcerans thioesterase 0.3442 0.4386 0.5436
Echinococcus granulosus snurportin 1 0.0372 0.0443 0.2832
Chlamydia trachomatis 3-oxoacyl-ACP synthase 0.1037 0.1297 1
Schistosoma mansoni hypothetical protein 0.0044 0.0023 0.0079
Mycobacterium ulcerans oxidoreductase 0.0257 0.0295 0.0083
Mycobacterium tuberculosis Possible dehydrogenase 0.0257 0.0295 0.0173
Mycobacterium tuberculosis Probable alcohol dehydrogenase AdhA 0.0257 0.0295 0.0173
Toxoplasma gondii type I fatty acid synthase 0.0634 0.078 0.138
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0112 0.0109 0.0109
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.3308 0.4214 0.5211
Mycobacterium ulcerans acyl carrier protein 0.0417 0.0502 0.0353
Mycobacterium ulcerans dehydrogenase 0.0257 0.0295 0.0083
Schistosoma mansoni hypothetical protein 0.0205 0.0229 0.1404
Loa Loa (eye worm) hypothetical protein 0.011 0.0107 0.0109
Loa Loa (eye worm) fatty acid synthase 0.4075 0.52 0.5865
Mycobacterium tuberculosis Probable fatty acid synthase Fas (fatty acid synthetase) 0.1297 0.1632 0.1906
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0257 0.0295 0.2264
Leishmania major hypothetical protein, conserved 0.0261 0.0301 0.1912
Mycobacterium ulcerans NADP-dependent alcohol dehydrogenase AdhC 0.0257 0.0295 0.0083
Echinococcus granulosus muscleblind protein 0.0106 0.0103 0.0601
Echinococcus multilocularis carbonic anhydrase 0.011 0.0107 0.0633
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.011 0.0107 0.0107
Mycobacterium tuberculosis Probable polyketide beta-ketoacyl synthase Pks3 0.0634 0.078 0.0801
Mycobacterium ulcerans polyketide synthase 0.4115 0.525 0.6567
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.0443 0.0489
Leishmania major NADP-dependent alcohol dehydrogenase, putative 0.0257 0.0295 0.1878
Trypanosoma brucei acyl transferase-like protein 0.0261 0.0301 0.2255
Schistosoma mansoni alcohol dehydrogenase 0.0257 0.0295 0.1833
Mycobacterium ulcerans polyketide synthase MbtD 0.127 0.1597 0.1786
Mycobacterium ulcerans zinc-type alcohol dehydrogenase AdhD 0.0257 0.0295 0.0083
Mycobacterium ulcerans polyketide synthase MbtC 0.1037 0.1297 0.1394
Mycobacterium tuberculosis Meromycolate extension acyl carrier protein AcpM 0.0417 0.0502 0.044
Echinococcus granulosus BC026374 protein S09 family 0.0207 0.0232 0.1446
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0112 0.0109 0.0646
Echinococcus multilocularis muscleblind protein 0.0106 0.0103 0.0601
Echinococcus multilocularis acetylcholinesterase 0.1224 0.1538 1
Leishmania major zinc-binding dehydrogenase-like protein 0.0257 0.0295 0.1878
Brugia malayi Carboxylesterase family protein 0.1224 0.1538 0.1538
Trypanosoma cruzi acyl transferase-like protein, putative 0.0261 0.0301 0.2305
Brugia malayi AMP-binding enzyme family protein 0.3866 0.4932 0.4932
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.4115 0.525 0.6567
Loa Loa (eye worm) hypothetical protein 0.0107 0.0104 0.0105
Loa Loa (eye worm) hypothetical protein 0.1224 0.1538 0.1727
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0257 0.0295 0.1878
Toxoplasma gondii type I fatty acid synthase, putative 0.4372 0.5581 1
Schistosoma mansoni hypothetical protein 0.0044 0.0023 0.0079
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.011 0.0107 0.0107
Toxoplasma gondii acyl carrier protein ACP 0.0417 0.0502 0.0881
Trypanosoma cruzi PAB1-binding protein , putative 0.0041 0.0019 0.0127
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0203 0.0227 0.1736
Toxoplasma gondii type I fatty acid synthase, putative 0.294 0.3742 0.6698
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0207 0.0232 0.009
Trypanosoma cruzi oxidoreductase, putative 0.0257 0.0295 0.2264
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0884 0.1101 0.7136
Schistosoma mansoni [ACP] S-malonyltransferase 0.0261 0.0301 0.1868
Schistosoma mansoni neuroligin 3 (S09 family) 0.0207 0.0232 0.1423
Mycobacterium leprae PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) 0.1297 0.1632 0.1764
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0257 0.0295 0.2264
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0207 0.0232 0.1446
Mycobacterium tuberculosis Probable polyketide beta-ketoacyl synthase Pks4 0.0634 0.078 0.0801
Mycobacterium tuberculosis Probable quinone reductase Qor (NADPH:quinone reductase) (zeta-crystallin homolog protein) 0.0257 0.0295 0.0173
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0207 0.0232 0.1423
Echinococcus multilocularis Malonyl coenzyme A acyl carrier protein transacylase 0.0261 0.0301 0.1899
Mycobacterium tuberculosis Probable polyketide synthase Pks17 0.1009 0.1262 0.1426
Schistosoma mansoni methyltransferase-related 0.1244 0.1564 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.0025 0.0016
Mycobacterium ulcerans NADP-dependent oxidoreductase 0.0257 0.0295 0.0083
Echinococcus granulosus Protein patched homolog 1 0.0046 0.0025 0.0094
Echinococcus multilocularis NADH dehydrogenase 0.0417 0.0502 0.3214
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] synthase i/ii, putative 0.1037 0.1297 1
Loa Loa (eye worm) hypothetical protein 0.0207 0.0232 0.025
Mycobacterium ulcerans Type I modular polyketide synthase 0.4115 0.525 0.6567
Loa Loa (eye worm) hypothetical protein 0.0207 0.0232 0.025
Mycobacterium tuberculosis Conserved protein 0.1244 0.1564 0.1818
Echinococcus granulosus acetylcholinesterase 0.1224 0.1538 1
Wolbachia endosymbiont of Brugia malayi acyl carrier protein 0.0417 0.0502 0.2059
Echinococcus multilocularis sterol regulatory element binding protein 0.0046 0.0025 0.0094
Mycobacterium ulcerans polyketide synthase 0.4371 0.558 0.6998
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0425 0.0512 0.0366
Loa Loa (eye worm) hypothetical protein 0.0207 0.0232 0.025
Brugia malayi Importin beta-1 subunit 0.0035 0.0011 0.0011
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.2348 0.2982 0.3656
Trypanosoma brucei Acyl carrier protein, mitochondrial 0.0417 0.0502 0.3816
Echinococcus granulosus Niemann Pick C1 protein 0.0153 0.0163 0.0996
Leishmania major d-xylulose reductase, putative 0.0257 0.0295 0.1878
Brugia malayi Carboxylesterase family protein 0.0207 0.0232 0.0232
Mycobacterium ulcerans Zn-dependent alcohol dehydrogenase, AdhX 0.0257 0.0295 0.0083
Loa Loa (eye worm) carboxylesterase 0.0207 0.0232 0.025
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0207 0.0232 0.1423
Entamoeba histolytica NADP-dependent alcohol dehydrogenase 0.0257 0.0295 0.5504
Mycobacterium tuberculosis Acyl carrier protein (ACP) MbtL 0.0417 0.0502 0.044
Loa Loa (eye worm) hypothetical protein 0.0106 0.0103 0.0104
Mycobacterium ulcerans polyketide synthase Pks13 0.6158 0.7874 1
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0257 0.0295 0.0295
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0107 0.0104 0.1906
Echinococcus granulosus acyl carrier protein mitochondrial 0.0417 0.0502 0.3214
Onchocerca volvulus 0.0257 0.0295 0.0069
Loa Loa (eye worm) hypothetical protein 0.0207 0.0232 0.025
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0112 0.0109 0.0635
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0425 0.0512 0.0512
Mycobacterium ulcerans thioesterase TesA 0.3442 0.4386 0.5436
Loa Loa (eye worm) hypothetical protein 0.0257 0.0295 0.0322
Plasmodium falciparum 3-oxoacyl-acyl-carrier protein synthase I/II 0.1037 0.1297 1
Echinococcus granulosus NADH dehydrogenase 0.0417 0.0502 0.3214
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.3308 0.4214 0.5171
Schistosoma mansoni acetylcholinesterase 0.0207 0.0232 0.1423
Mycobacterium leprae Probable polyketide synthase Pks1 0.4371 0.558 0.6973
Onchocerca volvulus 0.3866 0.4932 0.5056
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0257 0.0295 0.2264
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0207 0.0232 0.009
Trypanosoma brucei PAB1-binding protein , putative 0.0041 0.0019 0.0062
Leishmania major beta-ketoacyl synthase family protein, putative,3-oxoacyl-acyl carrier protein synthase ii, putative 0.1037 0.1297 0.8293
Echinococcus multilocularis carbonic anhydrase 0.011 0.0107 0.0633
Plasmodium vivax malonyl CoA-acyl carrier protein transacylase precursor, putative 0.0261 0.0301 0.2255
Plasmodium falciparum malonyl CoA-acyl carrier protein transacylase 0.0261 0.0301 0.2255
Echinococcus granulosus para nitrobenzyl esterase 0.0207 0.0232 0.1446
Brugia malayi RNA, U transporter 1 0.0099 0.0093 0.0093
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.167 0.2111 0.2527
Trypanosoma brucei oxidoreductase, putative 0.0257 0.0295 0.2213
Trypanosoma brucei carbonic anhydrase-like protein 0.0203 0.0227 0.1682
Brugia malayi Methyltransferase-like protein 4 0.1244 0.1564 0.1564
Mycobacterium leprae PROBABLE POLYKETIDE BETA-KETOACYL SYNTHASE PKS4 0.0634 0.078 0.0639
Mycobacterium tuberculosis Polyketide synthase Pks2 0.4004 0.5108 0.6413
Echinococcus multilocularis carbonic anhydrase 0.011 0.0107 0.0633
Mycobacterium tuberculosis Probable alcohol dehydrogenase Adh 0.0257 0.0295 0.0173
Mycobacterium leprae Polyketide synthase Pks13 0.6158 0.7874 1
Mycobacterium ulcerans 3-oxoacyl-(acyl carrier protein) synthase II 0.1037 0.1297 0.1394
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0257 0.0295 0.2264

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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