TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 454.517 | Formula: C28H26N2O4
H donors: 0 H acceptors: 3 LogP: 4.64 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: O=C1O[C@](C(=O)N1[C@@H](c1ccccc1)C)(Cc1ccccc1)C(=O)N1CCc2c(C1)cccc2
InChi: 1S/C28H26N2O4/c1-20(22-12-6-3-7-13-22)30-26(32)28(34-27(30)33,18-21-10-4-2-5-11-21)25(31)29-17-16-23-14-8-9-15-24(23)19-29/h2-15,20H,16-19H2,1H3/t20-,28-/m1/s1
InChiKey: DSGAHISJOFLORU-PIIWDFAUSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	nuclear receptor subfamily 3, group C, member 2	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	conserved hypothetical protein	0.0052	0.1147	0.1999
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0012	0.0146	0.0145
Loa Loa (eye worm)	steroid hormone receptor	0.0012	0.0146	0.0151
Echinococcus multilocularis	beta 1 syntrophin	0.0008	0.0047	0.0046
Leishmania major	folate/biopterin transporter, putative	0.001	0.0079	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0596	0.0595
Schistosoma mansoni	regulator of G protein signaling	0.0052	0.1147	0.1147
Schistosoma mansoni	hypothetical protein	0.0016	0.023	0.023
Echinococcus multilocularis	Oxysterol binding protein 11	0.0008	0.0047	0.0046
Brugia malayi	PH domain containing protein	0.0008	0.0047	0.0092
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0685	0.0713
Brugia malayi	steroid hormone receptor	0.0012	0.0146	0.0288
Brugia malayi	Syntrophin-1	0.0008	0.0047	0.0092
Schistosoma mansoni	centaurin alpha	0.0008	0.0047	0.0046
Trypanosoma cruzi	NIMA-related kinase, putative	0.001	0.0079	1
Schistosoma mansoni	hypothetical protein	0.0034	0.0685	0.0684
Schistosoma mansoni	syntrophin	0.0008	0.0047	0.0046
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0016	0.023	0.023
Loa Loa (eye worm)	hypothetical protein	0.0052	0.1147	0.1194
Brugia malayi	Cadps2 protein	0.0008	0.0047	0.0092
Trypanosoma brucei	rac serine-threonine kinase, putative	0.001	0.0079	1
Echinococcus multilocularis	FTZ F1 alpha	0.0012	0.0146	0.0145
Brugia malayi	Variant SH3 domain containing protein	0.0008	0.0047	0.0092
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0012	0.0146	0.0288
Schistosoma mansoni	hypothetical protein	0.0008	0.0047	0.0046
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0012	0.0146	0.0145
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0047	0.0048
Brugia malayi	PH domain containing protein	0.0008	0.0047	0.0092
Trichomonas vaginalis	AGC family protein kinase	0.001	0.0079	0.0137
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0016	0.023	0.0239
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.0173	0.4185	0.4358
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0052	0.1147	0.1147
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0047	0.0082
Trichomonas vaginalis	AGC family protein kinase	0.001	0.0079	0.0137
Trichomonas vaginalis	AGC family protein kinase	0.001	0.0079	0.0137
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0008	0.0047	0.0048
Echinococcus multilocularis	ecdysone induced protein 78C	0.0012	0.0146	0.0145
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0012	0.0146	0.0288
Loa Loa (eye worm)	PH domain-containing protein	0.0008	0.0047	0.0048
Echinococcus multilocularis	cytohesin 1	0.0008	0.0047	0.0046
Schistosoma mansoni	serine/threonine protein kinase	0.0388	0.9601	0.9601
Schistosoma mansoni	zinc finger protein	0.0008	0.0047	0.0046
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.001	0.0079	1
Echinococcus granulosus	beta-adrenergic receptor kinase	0.0388	0.9601	0.9601
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0012	0.0146	0.0145
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0047	0.0048
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.0121	0.2876	0.5724
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0047	0.0082
Schistosoma mansoni	cpg binding protein	0.0028	0.0552	0.0551
Schistosoma mansoni	phosphoinositol 4-phosphate adaptor protein	0.0008	0.0047	0.0046
Brugia malayi	PH domain containing protein	0.0008	0.0047	0.0092
Leishmania major	serine/threonine-protein kinase a, putative	0.001	0.0079	1
Loa Loa (eye worm)	hypothetical protein	0.0052	0.1147	0.1194
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0596	0.0595
Schistosoma mansoni	axis inhibition protein axin	0.0052	0.1147	0.1147
Brugia malayi	regulator of G-protein signaling egl-10	0.0052	0.1147	0.2282
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0016	0.023	0.023
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0012	0.0146	0.0145
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0047	0.0048
Trichomonas vaginalis	AGC family protein kinase	0.001	0.0079	0.0137
Echinococcus multilocularis	GPCR, family 2	0.0016	0.023	0.023
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0047	0.0048
Echinococcus granulosus	axis inhibition protein axin	0.0052	0.1147	0.1147
Loa Loa (eye worm)	G protein-coupled receptor kinase 1	0.0121	0.2876	0.2995
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0012	0.0146	0.0288
Echinococcus granulosus	dynamin 1	0.0008	0.0047	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0146	0.0151
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0012	0.0146	0.0288
Echinococcus granulosus	Pleckstrin y	0.0008	0.0047	0.0046
Echinococcus multilocularis	type II inositol 3,4 bisphosphate 4 phosphatase	0.0008	0.0047	0.0046
Trypanosoma brucei	protein kinase, putative	0.001	0.0079	1
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0012	0.0146	0.0173
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0052	0.1147	0.2282
Echinococcus multilocularis	regulator of G protein signaling 3	0.0052	0.1147	0.1147
Echinococcus multilocularis	actin binding protein anillin	0.0008	0.0047	0.0046
Entamoeba histolytica	PH domain containing protein kinase, putative	0.001	0.0079	0.0286
Schistosoma mansoni	hypothetical protein	0.0008	0.0047	0.0046
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.003	0.0596	0.0595
Entamoeba histolytica	ARF GTPase activating protein, putative	0.0008	0.0047	0.00000028235
Schistosoma mansoni	hypothetical protein	0.0008	0.0047	0.0046
Brugia malayi	hypothetical protein	0.0008	0.0047	0.0092
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.001	0.0086	0.0086
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0146	0.0151
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0047	0.0048
Echinococcus granulosus	expressed protein	0.0052	0.1147	0.1147
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0012	0.0146	0.0145
Schistosoma mansoni	regulator of G protein signaling 3 rgs3	0.0052	0.1147	0.1147
Trichomonas vaginalis	AGC family protein kinase	0.001	0.0079	0.0137
Loa Loa (eye worm)	uncoordinated protein 104	0.0008	0.0047	0.0048
Echinococcus granulosus	beta 1 syntrophin	0.0008	0.0047	0.0046
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0008	0.0047	0.0092
Trichomonas vaginalis	ankyrin 2,3/unc44, putative	0.0008	0.0047	0.0082
Brugia malayi	Uncoordinated protein 104	0.0008	0.0047	0.0092
Echinococcus granulosus	pdz domain containing protein	0.0008	0.0047	0.0046
Trypanosoma cruzi	NEK family Serine/threonine-protein kinase, putative	0.001	0.0079	1
Loa Loa (eye worm)	hypothetical protein	0.0052	0.1147	0.1194
Echinococcus multilocularis	pdz domain containing protein	0.0008	0.0047	0.0046
Plasmodium vivax	calcium-dependent protein kinase 7, putative	0.001	0.0079	0.0574
Echinococcus granulosus	Pleckstrin y	0.0008	0.0047	0.0046
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0012	0.0146	0.0288
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.003	0.0596	0.0595
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0047	0.0082
Entamoeba histolytica	protein kinase, putative	0.001	0.0079	0.0286
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0012	0.0146	0.0145
Echinococcus granulosus	calcium dependent secretion activator 1	0.0008	0.0047	0.0046
Echinococcus multilocularis	Ras associated and pleckstrin y	0.0008	0.0047	0.0046
Echinococcus granulosus	DCC interacting protein 13 beta	0.0008	0.0047	0.0046
Loa Loa (eye worm)	Plekhf2 protein	0.0008	0.0047	0.0048
Loa Loa (eye worm)	RhoGEF domain-containing protein	0.0008	0.0047	0.0048
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0047	0.0082
Echinococcus multilocularis	Arf GAP and Pleckstrin domain containing protein	0.0008	0.0047	0.0046
Schistosoma mansoni	regulator of G protein signaling	0.0052	0.1147	0.1147
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0012	0.0146	0.0145
Trichomonas vaginalis	AGC family protein kinase	0.001	0.0079	0.0137
Schistosoma mansoni	rhogef and pleckstrin domain protein	0.0008	0.0047	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0016	0.023	0.0239
Schistosoma mansoni	goodpasture antigen-binding protein	0.0008	0.0047	0.0046
Trichomonas vaginalis	conserved hypothetical protein	0.0052	0.1147	0.1999
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0028	0.0553	0.0552
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0047	0.0082
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0047	0.0048
Toxoplasma gondii	calcium dependent protein kinase CDPK7	0.001	0.0079	0.0269
Trichomonas vaginalis	AGC family protein kinase	0.001	0.0079	0.0137
Trypanosoma cruzi	serine/threonine-protein kinase NRKB, putative	0.001	0.0079	1
Echinococcus multilocularis	myotubularin protein 13	0.0008	0.0047	0.0046
Echinococcus granulosus	Rho GTPase activating protein 24	0.0008	0.0047	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0047	0.0048
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.0052	0.1147	0.1194
Entamoeba histolytica	hypothetical protein	0.001	0.0079	0.0286
Entamoeba histolytica	PH domain containing protein kinase, putative	0.001	0.0079	0.0286
Brugia malayi	PH domain containing protein	0.0008	0.0047	0.0092
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.001	0.0086	0.0086
Echinococcus multilocularis	rac serine:threonine kinase	0.001	0.0079	0.0078
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.001	0.0079	1
Trichomonas vaginalis	kinesin light chain, putative	0.0008	0.0047	0.0082
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0047	0.0082
Loa Loa (eye worm)	cytohesin 3	0.0008	0.0047	0.0048
Entamoeba histolytica	PH domain containing protein kinase, putative	0.001	0.0079	0.0286
Schistosoma mansoni	serine/threonine-protein kinase	0.001	0.0079	0.0078
Brugia malayi	hypothetical protein	0.0052	0.1147	0.2282
Trichomonas vaginalis	development and differentiation-enhancing factor, ddef, putative	0.0008	0.0047	0.0082
Echinococcus multilocularis	FERM and pleckstrin domain containing protein	0.0008	0.0047	0.0046
Echinococcus granulosus	Pleckstrin y	0.0008	0.0047	0.0046
Brugia malayi	Dynamin	0.0008	0.0047	0.0092
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0047	0.0048
Echinococcus multilocularis	GRB2 associated binding protein 3	0.0008	0.0047	0.0046
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.0388	0.9601	1
Trichomonas vaginalis	ankyrin repeat and FYVE domain containing protein, putative	0.0008	0.0047	0.0082
Echinococcus multilocularis	Rho GTPase activating protein 24	0.0008	0.0047	0.0046
Echinococcus granulosus	histone lysine methyltransferase setb	0.003	0.0596	0.0595
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0146	0.0151
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0008	0.0043	0.0042
Trichomonas vaginalis	centaurin/arf, putative	0.0008	0.0047	0.0082
Echinococcus multilocularis	oxysterol binding protein 1	0.0008	0.0047	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0052	0.1147	0.1194
Schistosoma mansoni	regulator of G protein signaling	0.0052	0.1147	0.1147
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0016	0.023	0.0457
Onchocerca volvulus		0.0234	0.5739	1
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.0685	0.1362
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0047	0.0082
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0047	0.0082
Echinococcus granulosus	GRB2 associated binding protein 3	0.0008	0.0047	0.0046
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0012	0.0146	0.0151
Trypanosoma brucei	serine/threonine-protein kinase NRKB, putative	0.001	0.0079	1
Brugia malayi	PXA domain containing protein	0.0052	0.1147	0.2282
Leishmania major	rac serine-threonine kinase, putative,protein kinase, putative	0.001	0.0079	1
Entamoeba histolytica	protein kinase, putative	0.001	0.0079	0.0286
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0047	0.0082
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0012	0.0146	0.0288
Trichomonas vaginalis	hypothetical protein	0.0008	0.0047	0.0082
Trichomonas vaginalis	AGC family protein kinase	0.001	0.0079	0.0137
Echinococcus multilocularis	arf GAP with SH3 domain, ANK repeat and PH	0.0008	0.0047	0.0046
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0055	0.1217	1
Echinococcus granulosus	oxysterol binding protein 1	0.0008	0.0047	0.0046
Brugia malayi	probable spectrin beta chain	0.0008	0.0047	0.0092
Echinococcus granulosus	ras specific guanine nucleotide releasing factor	0.0008	0.0047	0.0046
Brugia malayi	Oxysterol-binding protein	0.0008	0.0047	0.0092
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0008	0.0043	0.0042
Echinococcus granulosus	ecdysone induced protein 78C	0.0012	0.0146	0.0145
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0047	0.0082
Echinococcus granulosus	arf GAP with coiled coil ANK repeat and PH	0.0008	0.0047	0.0046
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0012	0.0146	0.0288
Trichomonas vaginalis	protein transport protein sec7, putative	0.0008	0.0047	0.0082
Echinococcus multilocularis	regulator of G protein signaling	0.0052	0.1147	0.1147
Entamoeba histolytica	protein kinase, putative	0.001	0.0079	0.0286
Loa Loa (eye worm)	oxysterol binding protein	0.0008	0.0047	0.0048
Echinococcus granulosus	Pleckstrin domain containing protein family B	0.0008	0.0047	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0049	0.1077	0.1121
Schistosoma mansoni	zinc finger protein	0.0008	0.0047	0.0046
Echinococcus granulosus	Oxysterol binding protein 11	0.0008	0.0047	0.0046
Brugia malayi	GTPase-activator protein for Ras-like GTPase containing protein	0.0008	0.0047	0.0092
Schistosoma mansoni	hypothetical protein	0.0016	0.023	0.023
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0012	0.0146	0.0145
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0012	0.0146	0.0288
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0146	0.0151
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0047	0.0048
Echinococcus multilocularis	Pleckstrin y	0.0008	0.0047	0.0046
Schistosoma mansoni	growth factor receptor-bound protein	0.0008	0.0047	0.0046
Entamoeba histolytica	protein kinase, putative	0.001	0.0079	0.0286
Brugia malayi	Steroid receptor seven-up type 2	0.0012	0.0146	0.0288
Trichomonas vaginalis	AGC family protein kinase	0.001	0.0079	0.0137
Echinococcus granulosus	myotubularin protein 13	0.0008	0.0047	0.0046
Schistosoma mansoni	dynamin	0.0008	0.0047	0.0046
Schistosoma mansoni	RAR-like nuclear receptor	0.0012	0.0146	0.0145
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0012	0.0146	0.0151
Echinococcus multilocularis	oxysterol binding protein 3	0.0008	0.0047	0.0046
Schistosoma mansoni	dynamin	0.0008	0.0047	0.0046
Loa Loa (eye worm)	rho-GTPase-activating	0.0008	0.0047	0.0048
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0047	0.0082
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0016	0.023	0.023
Entamoeba histolytica	hypothetical protein	0.0052	0.1147	1
Trichomonas vaginalis	ribosomal protein S6 kinase, 90kD, polypeptide, putative	0.001	0.0079	0.0137
Schistosoma mansoni	coup transcription factor	0.0012	0.0146	0.0145
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0012	0.0146	0.0145
Brugia malayi	Pre-SET motif family protein	0.0206	0.5024	1
Brugia malayi	PH domain containing protein	0.0008	0.0047	0.0092
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0146	0.0151
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0047	0.0048
Echinococcus granulosus	[G-protein-coupledreceptor] kinase	0.0121	0.2876	0.2876
Onchocerca volvulus	Protein ultraspiracle homolog	0.0012	0.0146	0.0173
Brugia malayi	nuclear receptor NHR-88	0.0012	0.0146	0.0288
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0146	0.0151
Trichomonas vaginalis	centaurin beta, putative	0.0008	0.0047	0.0082
Trichomonas vaginalis	AGC family protein kinase	0.001	0.0079	0.0137
Brugia malayi	hypothetical protein	0.0052	0.1147	0.2282
Echinococcus granulosus	regulator of G protein signaling 7	0.0052	0.1147	0.1147
Schistosoma mansoni	myotubularin-related protein	0.0008	0.0047	0.0046
Trichomonas vaginalis	AGC family protein kinase	0.001	0.0079	0.0137
Brugia malayi	TBC domain containing protein	0.0008	0.0047	0.0092
Brugia malayi	Variant SH3 domain containing protein	0.0008	0.0047	0.0092
Entamoeba histolytica	hypothetical protein	0.0052	0.1147	1
Schistosoma mansoni	rho gtpase activating protein	0.0008	0.0047	0.0046
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0012	0.0146	0.0151
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0146	0.0151
Trypanosoma cruzi	serine/threonine protein kinase, putative	0.001	0.0079	1
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0047	0.0048
Trichomonas vaginalis	centaurin/arf, putative	0.0008	0.0047	0.0082
Schistosoma mansoni	hypothetical protein	0.0404	1	1
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0008	0.0047	0.0092
Trichomonas vaginalis	AGC family protein kinase	0.001	0.0079	0.0137
Entamoeba histolytica	hypothetical protein	0.0052	0.1147	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0049	0.1077	0.2142
Echinococcus multilocularis	dnaJ subfamily B	0.0404	1	1
Loa Loa (eye worm)	syntrophin-1	0.0008	0.0047	0.0048
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0012	0.0146	0.0145
Brugia malayi	F/Y-rich N-terminus family protein	0.001	0.0084	0.0165
Echinococcus multilocularis	arf GAP with coiled coil, ANK repeat and PH	0.0008	0.0047	0.0046
Leishmania major	protein kinase, putative,serine/threonine protein kinase, putative	0.001	0.0079	1
Leishmania major	protein kinase, putative	0.001	0.0079	1
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0012	0.0146	0.0145
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0012	0.0146	0.0288
Trichomonas vaginalis	guanyl-nucleotide exchange factor, putative	0.0008	0.0047	0.0082
Brugia malayi	nuclear hormone receptor	0.0012	0.0146	0.0288
Schistosoma mansoni	thyroid hormone receptor	0.0012	0.0146	0.0145
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0047	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0047	0.0048
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0008	0.0047	0.0082
Entamoeba histolytica	hypothetical protein	0.001	0.0079	0.0286
Trichomonas vaginalis	AGC family protein kinase	0.001	0.0079	0.0137
Loa Loa (eye worm)	histone methyltransferase	0.001	0.0086	0.0089
Schistosoma mansoni	cpg binding protein	0.003	0.0593	0.0592
Echinococcus multilocularis	collagen type iv alpha 3 binding protein	0.0008	0.0047	0.0046
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0012	0.0146	0.0145
Onchocerca volvulus		0.0012	0.0146	0.0173
Echinococcus granulosus	pleckstrin y domain containing family A	0.0008	0.0047	0.0046
Echinococcus granulosus	regulator of G protein signaling 3	0.0052	0.1147	0.1147
Trichomonas vaginalis	centaurin alpha, putative	0.0008	0.0047	0.0082
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0028	0.0552	0.0574
Brugia malayi	regulator of G-protein signaling rgs-7	0.0052	0.1147	0.2282
Trichomonas vaginalis	regulator of G protein signaling 5, rgs5, putative	0.0052	0.1147	0.1999
Schistosoma mansoni	serine/threonine protein kinase	0.0173	0.4185	0.4185
Schistosoma mansoni	oxysterol-binding protein 1	0.0008	0.0047	0.0046
Plasmodium falciparum	calcium-dependent protein kinase 7	0.001	0.0079	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0012	0.0146	0.0151
Brugia malayi	Oxysterol binding protein	0.0008	0.0047	0.0092
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0012	0.0146	0.0145
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0012	0.0146	0.0145
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0047	0.0082
Trichomonas vaginalis	AGC family protein kinase	0.001	0.0079	0.0137
Entamoeba histolytica	PH domain containing protein kinase, putative	0.001	0.0079	0.0286
Loa Loa (eye worm)	PXA domain-containing protein	0.0052	0.1147	0.1194
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0008	0.0043	0.0042
Schistosoma mansoni	hypothetical protein	0.0016	0.023	0.023
Echinococcus multilocularis	Pleckstrin domain containing protein, family B	0.0008	0.0047	0.0046
Echinococcus multilocularis	expressed protein	0.0052	0.1147	0.1147
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.001	0.0079	1
Brugia malayi	Pleckstrin Homology Domain	0.0008	0.0047	0.0092
Entamoeba histolytica	PH domain containing protein kinase, putative	0.001	0.0079	0.0286
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0008	0.0043	0.0042
Trichomonas vaginalis	AGC family protein kinase	0.001	0.0079	0.0137
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0047	0.0048
Entamoeba histolytica	p21-activated kinase	0.001	0.0079	0.0286
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0052	0.1147	0.1147
Schistosoma mansoni	nuclear hormone receptor	0.0012	0.0146	0.0145
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0047	0.0082
Schistosoma mansoni	hypothetical protein	0.0016	0.023	0.023
Echinococcus multilocularis	calcium dependent secretion activator 1	0.0008	0.0047	0.0046
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0016	0.023	0.023
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0047	0.0048
Trichomonas vaginalis	AGC family protein kinase	0.001	0.0079	0.0137
Trichomonas vaginalis	protein transport protein sec7, putative	0.0008	0.0047	0.0082
Trypanosoma cruzi	Protein kinase B	0.001	0.0079	1
Trichomonas vaginalis	centaurin gamma, putative	0.0008	0.0047	0.0082
Loa Loa (eye worm)	hypothetical protein	0.003	0.0596	0.062
Trichomonas vaginalis	conserved hypothetical protein	0.0052	0.1147	0.1999
Trichomonas vaginalis	AGC family protein kinase	0.001	0.0079	0.0137
Plasmodium vivax	SET domain protein, putative	0.003	0.0596	1
Brugia malayi	PXA domain containing protein	0.0052	0.1147	0.2282
Schistosoma mansoni	z-protein (S1r protein)	0.0052	0.1147	0.1147
Toxoplasma gondii	protein kinase domain-containing protein	0.001	0.0079	0.0269
Echinococcus multilocularis	Regulator of G protein signaling 20	0.0052	0.1147	0.1147
Entamoeba histolytica	PH domain containing protein kinase, putative	0.001	0.0079	0.0286
Brugia malayi	Pre-SET motif family protein	0.003	0.0596	0.1184
Echinococcus granulosus	axis inhibition protein axin	0.0052	0.1147	0.1147
Onchocerca volvulus		0.003	0.0596	0.0964
Entamoeba histolytica	protein kinase, putative	0.001	0.0079	0.0286
Echinococcus granulosus	Regulator of G protein signaling 20	0.0052	0.1147	0.1147
Loa Loa (eye worm)	hypothetical protein	0.0052	0.1147	0.1194
Brugia malayi	Nuclear hormone receptor-like 1	0.0012	0.0146	0.0288
Trypanosoma brucei	NEK family Serine/threonine-protein kinase, putative	0.001	0.0079	1
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0052	0.1147	0.2282
Trichomonas vaginalis	AGC family protein kinase	0.001	0.0079	0.0137
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.0121	0.2876	0.2995
Schistosoma mansoni	goodpasture antigen-binding protein	0.0008	0.0047	0.0046
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0012	0.0146	0.0145
Trichomonas vaginalis	AGC family protein kinase	0.001	0.0079	0.0137
Echinococcus granulosus	FTZ F1 alpha	0.0012	0.0146	0.0145
Echinococcus granulosus	serine/threonine protein kinase	0.001	0.0079	0.0078
Echinococcus granulosus	cytohesin 1	0.0008	0.0047	0.0046
Entamoeba histolytica	protein kinase, putative	0.001	0.0079	0.0286
Echinococcus multilocularis	regulator of G protein signaling 7	0.0052	0.1147	0.1147
Brugia malayi	PH domain containing protein	0.0008	0.0047	0.0092
Schistosoma mansoni	regulator of G protein signaling	0.0052	0.1147	0.1147
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0012	0.0146	0.0145
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0047	0.0048
Echinococcus granulosus	oxysterol binding protein 3	0.0008	0.0047	0.0046
Trichomonas vaginalis	conserved hypothetical protein	0.0052	0.1147	0.1999
Echinococcus granulosus	Arf GAP and Pleckstrin domain containing protein	0.0008	0.0047	0.0046
Echinococcus multilocularis	axis inhibition protein axin	0.0052	0.1147	0.1147
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.001	0.0079	1
Loa Loa (eye worm)	AGC/AKT protein kinase	0.001	0.0079	0.0081
Echinococcus multilocularis	oxysterol binding protein 9	0.0008	0.0047	0.0046
Trichomonas vaginalis	alpha chimerin, putative	0.0008	0.0047	0.0082
Echinococcus multilocularis	cpg binding protein	0.003	0.0593	0.0592
Echinococcus multilocularis	dynamin 1	0.0008	0.0047	0.0046
Schistosoma mansoni	axis inhibition protein axin	0.0052	0.1147	0.1147
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0012	0.0146	0.0288
Schistosoma mansoni	oxysterol-binding protein 1	0.0008	0.0047	0.0046
Echinococcus granulosus	FERM and pleckstrin domain containing protein	0.0008	0.0047	0.0046
Echinococcus multilocularis	beta adrenergic receptor kinase	0.0388	0.9601	0.9601
Brugia malayi	Plekhf2 protein	0.0008	0.0047	0.0092
Echinococcus multilocularis	pleckstrin y domain containing family A	0.0008	0.0047	0.0046
Schistosoma mansoni	development and differentiation-enhancing factor ddef	0.0008	0.0047	0.0046
Schistosoma mansoni	vav2	0.0008	0.0047	0.0046
Echinococcus granulosus	regulator of G protein signaling 7	0.0052	0.1147	0.1147
Echinococcus granulosus	oxysterol binding protein 9	0.0008	0.0047	0.0046
Echinococcus granulosus	cpg binding protein	0.003	0.0593	0.0592
Echinococcus multilocularis	regulator of G protein signaling 3	0.0052	0.1147	0.1147
Echinococcus multilocularis	DCC interacting protein 13 beta	0.0008	0.0047	0.0046
Echinococcus multilocularis	axis inhibition protein axin	0.0052	0.1147	0.1147
Echinococcus granulosus	collagen type iv alpha 3 binding protein	0.0008	0.0047	0.0046
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0012	0.0146	0.0145
Trypanosoma cruzi	NIMA-related kinase, putative	0.001	0.0079	1
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0061	0.1379	0.1378
Trichomonas vaginalis	AGC family protein kinase	0.001	0.0079	0.0137
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0008	0.0043	0.0042
Echinococcus granulosus	GPCR family 2	0.0016	0.023	0.023
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0047	0.0048
Trichomonas vaginalis	AGC family protein kinase	0.001	0.0079	0.0137
Schistosoma mansoni	serine/threonine protein kinase	0.0388	0.9601	0.9601
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0012	0.0146	0.0151
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0012	0.0146	0.0151
Echinococcus multilocularis	A kinase anchor protein 10, mitochondrial	0.0052	0.1147	0.1147
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0012	0.0146	0.0288
Onchocerca volvulus	Bile acid receptor homolog	0.0012	0.0146	0.0173
Brugia malayi	Dynamin	0.0008	0.0047	0.0092
Echinococcus multilocularis	Pleckstrin y	0.0008	0.0047	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0047	0.0048
Brugia malayi	MAX-1A	0.0008	0.0047	0.0092
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0047	0.0048
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.003	0.0596	0.0595
Echinococcus multilocularis	G protein coupled receptor kinase 1	0.0336	0.8293	0.8292
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0012	0.0146	0.0145
Trichomonas vaginalis	AGC family protein kinase	0.001	0.0079	0.0137
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0012	0.0146	0.0145
Trichomonas vaginalis	set domain proteins, putative	0.0234	0.5739	1
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.001	0.0079	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0146	0.0151
Brugia malayi	ecdysteroid receptor	0.0012	0.0146	0.0288
Echinococcus multilocularis	ras specific guanine nucleotide releasing factor	0.0008	0.0047	0.0046
Echinococcus granulosus	type II inositol 34 bisphosphate 4 phosphatase	0.0008	0.0047	0.0046
Brugia malayi	PH domain containing protein	0.0008	0.0047	0.0092
Trichomonas vaginalis	conserved hypothetical protein	0.0052	0.1147	0.1999
Schistosoma mansoni	serine/threonine-protein kinase	0.001	0.0079	0.0078
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0008	0.0047	0.0048
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.001	0.0079	1
Brugia malayi	photoreceptor-specific nuclear receptor	0.0012	0.0146	0.0288
Brugia malayi	Latrophilin receptor protein 2	0.0016	0.023	0.0457
Trichomonas vaginalis	AGC family protein kinase	0.001	0.0079	0.0137
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0012	0.0146	0.0288
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.0173	0.4185	0.8329
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0012	0.0146	0.0145
Echinococcus granulosus	A kinase anchor protein 10 mitochondrial	0.0052	0.1147	0.1147
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0008	0.0047	0.0082
Echinococcus granulosus	G protein coupled receptor kinase 1	0.0336	0.8293	0.8292
Schistosoma mansoni	hypothetical protein	0.0008	0.0047	0.0046
Trypanosoma brucei	serine/threonine-protein kinase NrkA	0.001	0.0079	1
Schistosoma mansoni	hypothetical protein	0.0008	0.0047	0.0046
Trichomonas vaginalis	conserved hypothetical protein	0.0052	0.1147	0.1999
Loa Loa (eye worm)	hypothetical protein	0.0052	0.1147	0.1194
Brugia malayi	Cytohesin 3	0.0008	0.0047	0.0092
Trichomonas vaginalis	3-phosphoinositide dependent protein kinase-1, putative	0.001	0.0079	0.0137
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.003	0.0596	0.4687
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0049	0.1077	0.2142
Loa Loa (eye worm)	RGS-3 protein	0.0052	0.1147	0.1194
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0047	0.0082
Entamoeba histolytica	protein kinase, putative	0.001	0.0079	0.0286
Trichomonas vaginalis	AGC family protein kinase	0.001	0.0079	0.0137
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0012	0.0146	0.0288
Echinococcus multilocularis	regulator of G protein signaling 7	0.0052	0.1147	0.1147
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0596	0.0595
Brugia malayi	PH domain containing protein	0.0008	0.0047	0.0092
Schistosoma mansoni	thyroid hormone receptor	0.0012	0.0146	0.0145
Schistosoma mansoni	regulator of G protein signaling	0.0052	0.1147	0.1147
Trypanosoma brucei	Serine/threonine-protein kinase NEK21, putative	0.001	0.0079	1
Trichomonas vaginalis	AGC family protein kinase	0.001	0.0079	0.0137
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0049	0.1077	0.1121
Echinococcus multilocularis	G protein coupled receptor kinase 6	0.0121	0.2876	0.2876
Brugia malayi	PH domain containing protein	0.0008	0.0047	0.0092
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0012	0.0146	0.0145
Schistosoma mansoni	cpg binding protein	0.003	0.0593	0.0592
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0206	0.5024	0.5233
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0047	0.0048
Brugia malayi	Protein kinase domain containing protein	0.001	0.0079	0.0155
Trichomonas vaginalis	AGC family protein kinase	0.001	0.0079	0.0137
Trichomonas vaginalis	AGC family protein kinase	0.001	0.0079	0.0137
Brugia malayi	A-kinase anchor protein 10, precursor	0.0052	0.1147	0.2282
Onchocerca volvulus		0.0028	0.0552	0.0887
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0047	0.0082
Echinococcus multilocularis	Pleckstrin y	0.0008	0.0047	0.0046
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0012	0.0146	0.0151
Echinococcus granulosus	arf GAP with SH3 domain ANK repeat and PH	0.0008	0.0047	0.0046
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0008	0.0047	0.0048
Echinococcus granulosus	regulator of G protein signaling 3	0.0052	0.1147	0.1147
Trichomonas vaginalis	AGC family protein kinase	0.001	0.0079	0.0137
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0047	0.0082
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0047	0.0082
Brugia malayi	CXXC zinc finger family protein	0.0028	0.0552	0.1097
Schistosoma mansoni	guanyl-nucleotide exchange factor	0.0008	0.0047	0.0046
Leishmania major	protein kinase, putative	0.001	0.0079	1
Schistosoma mansoni	retinoic acid receptor RXR	0.0012	0.0146	0.0145

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.34 uM	Antagonist activity at human mineralocorticoid receptor assessed as inhibition of binding to coactivator peptide by NH Pro assay	ChEMBL.	23777778

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2407659

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1773159