Detailed information for compound 178041

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 516.678 | Formula: C30H40N6O2
  • H donors: 2 H acceptors: 2 LogP: 4.07 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCCCOc1ccccc1N1CCN(CC1)Cc1nc2c([nH]1)cccc2C(=O)NC1CN2CCC1CC2
  • InChi: 1S/C30H40N6O2/c1-2-3-19-38-27-10-5-4-9-26(27)36-17-15-35(16-18-36)21-28-31-24-8-6-7-23(29(24)33-28)30(37)32-25-20-34-13-11-22(25)12-14-34/h4-10,22,25H,2-3,11-21H2,1H3,(H,31,33)(H,32,37)
  • InChiKey: KKNDNGKMDFYCPN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Serotonin 1a (5-HT1a) receptor Starlite/ChEMBL References
Rattus norvegicus Serotonin 3 (5-HT3) receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis serotonin receptor Get druggable targets OG5_133249 All targets in OG5_133249
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma mansoni biogenic amine (5HT) receptor Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma japonicum expressed protein Get druggable targets OG5_133249 All targets in OG5_133249
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma japonicum Octopamine receptor, putative Get druggable targets OG5_133249 All targets in OG5_133249
Echinococcus granulosus biogenic amine 5HT receptor Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma japonicum ko:K04153 5-hydroxytryptamine (serotonin) receptor 1A, putative Get druggable targets OG5_133249 All targets in OG5_133249
Echinococcus multilocularis serotonin receptor Get druggable targets OG5_133249 All targets in OG5_133249
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Onchocerca volvulus Serotonin 3 (5-HT3) receptor   483 aa 452 aa 29.2 %
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative Serotonin 3 (5-HT3) receptor   483 aa 514 aa 23.2 %
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative Serotonin 3 (5-HT3) receptor   483 aa 478 aa 25.1 %
Loa Loa (eye worm) TYRA-2 protein Serotonin 1a (5-HT1a) receptor   422 aa 491 aa 27.3 %
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Serotonin 1a (5-HT1a) receptor   422 aa 417 aa 21.1 %
Schistosoma japonicum ko:K04207 neuropeptide Y receptor Y5, putative Serotonin 1a (5-HT1a) receptor   422 aa 339 aa 23.0 %
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor Serotonin 3 (5-HT3) receptor   483 aa 457 aa 26.9 %
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Serotonin 1a (5-HT1a) receptor   422 aa 448 aa 29.7 %
Onchocerca volvulus Putative zinc finger protein Serotonin 3 (5-HT3) receptor   483 aa 489 aa 25.8 %
Schistosoma japonicum Octopamine receptor 1, putative Serotonin 1a (5-HT1a) receptor   422 aa 424 aa 24.3 %
Onchocerca volvulus Serotonin 1a (5-HT1a) receptor   422 aa 426 aa 29.6 %
Loa Loa (eye worm) hypothetical protein Serotonin 1a (5-HT1a) receptor   422 aa 388 aa 26.5 %
Echinococcus granulosus g protein coupled receptor Serotonin 1a (5-HT1a) receptor   422 aa 432 aa 24.3 %
Onchocerca volvulus Serotonin 3 (5-HT3) receptor   483 aa 473 aa 27.5 %
Onchocerca volvulus 39S ribosomal protein L13, mitochondrial homolog Serotonin 3 (5-HT3) receptor   483 aa 490 aa 31.0 %
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Serotonin 1a (5-HT1a) receptor   422 aa 392 aa 20.7 %
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) Serotonin 3 (5-HT3) receptor   483 aa 503 aa 22.3 %
Echinococcus granulosus orexin receptor type 2 Serotonin 1a (5-HT1a) receptor   422 aa 369 aa 22.0 %
Echinococcus granulosus alpha 1A adrenergic receptor Serotonin 1a (5-HT1a) receptor   422 aa 452 aa 21.0 %
Onchocerca volvulus Large subunit GTPase 1 homolog Serotonin 3 (5-HT3) receptor   483 aa 394 aa 19.3 %
Schistosoma japonicum Neuronal acetylcholine receptor subunit alpha-3 precursor, putative Serotonin 3 (5-HT3) receptor   483 aa 505 aa 21.2 %
Onchocerca volvulus Serotonin 3 (5-HT3) receptor   483 aa 461 aa 24.3 %
Schistosoma japonicum Neuronal acetylcholine receptor subunit alpha-9-II precursor, putative Serotonin 3 (5-HT3) receptor   483 aa 457 aa 24.7 %
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit Serotonin 3 (5-HT3) receptor   483 aa 470 aa 27.7 %
Schistosoma japonicum ko:K04136 adrenergic receptor, alpha 1b, putative Serotonin 1a (5-HT1a) receptor   422 aa 444 aa 29.3 %
Onchocerca volvulus Acetylcholine receptor subunit alpha-type homolog Serotonin 3 (5-HT3) receptor   483 aa 482 aa 25.1 %
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein Serotonin 3 (5-HT3) receptor   483 aa 388 aa 21.9 %
Echinococcus multilocularis nAChR subunit Serotonin 3 (5-HT3) receptor   483 aa 495 aa 24.2 %
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit Serotonin 3 (5-HT3) receptor   483 aa 445 aa 25.6 %
Echinococcus multilocularis g protein coupled receptor Serotonin 1a (5-HT1a) receptor   422 aa 432 aa 23.6 %
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 Serotonin 3 (5-HT3) receptor   483 aa 387 aa 25.6 %
Onchocerca volvulus Serotonin 3 (5-HT3) receptor   483 aa 477 aa 26.6 %
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor Serotonin 1a (5-HT1a) receptor   422 aa 350 aa 20.6 %
Echinococcus multilocularis g protein coupled receptor Serotonin 1a (5-HT1a) receptor   422 aa 433 aa 22.4 %
Onchocerca volvulus Acetylcholine receptor subunit alpha-type homolog Serotonin 3 (5-HT3) receptor   483 aa 465 aa 27.3 %
Onchocerca volvulus Serotonin 3 (5-HT3) receptor   483 aa 489 aa 31.3 %
Loa Loa (eye worm) acetylcholine receptor alpha subunit Serotonin 3 (5-HT3) receptor   483 aa 484 aa 26.0 %
Echinococcus granulosus g protein coupled receptor Serotonin 1a (5-HT1a) receptor   422 aa 432 aa 23.4 %
Schistosoma mansoni amine GPCR Serotonin 1a (5-HT1a) receptor   422 aa 440 aa 31.6 %
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit Serotonin 3 (5-HT3) receptor   483 aa 445 aa 25.4 %
Onchocerca volvulus Acetylcholine receptor subunit alpha-type des-2 homolog Serotonin 3 (5-HT3) receptor   483 aa 464 aa 24.8 %
Onchocerca volvulus Acetylcholine receptor subunit alpha-type homolog Serotonin 3 (5-HT3) receptor   483 aa 465 aa 27.3 %
Onchocerca volvulus Mitochondrial inner membrane protein homolog Serotonin 1a (5-HT1a) receptor   422 aa 383 aa 30.5 %
Echinococcus multilocularis neuropeptides capa receptor Serotonin 1a (5-HT1a) receptor   422 aa 430 aa 20.0 %
Onchocerca volvulus Serotonin 1a (5-HT1a) receptor   422 aa 436 aa 23.9 %
Echinococcus multilocularis orexin receptor type 2 Serotonin 1a (5-HT1a) receptor   422 aa 369 aa 22.2 %
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit Serotonin 3 (5-HT3) receptor   483 aa 457 aa 26.7 %
Schistosoma japonicum ko:K04145 dopamine receptor D2, putative Serotonin 1a (5-HT1a) receptor   422 aa 410 aa 27.8 %
Brugia malayi Cation transporter family protein Serotonin 3 (5-HT3) receptor   483 aa 507 aa 28.2 %
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit Serotonin 3 (5-HT3) receptor   483 aa 470 aa 26.8 %
Onchocerca volvulus Serotonin 1a (5-HT1a) receptor   422 aa 407 aa 23.3 %
Brugia malayi acetylcholine receptor alpha subunit precursor, putative Serotonin 3 (5-HT3) receptor   483 aa 463 aa 26.8 %
Drosophila melanogaster nicotinic Acetylcholine Receptor alpha2 Serotonin 3 (5-HT3) receptor   483 aa 541 aa 25.5 %
Onchocerca volvulus Glycoprotein hormone beta 5 homolog Serotonin 1a (5-HT1a) receptor   422 aa 477 aa 24.3 %
Onchocerca volvulus Serotonin 1a (5-HT1a) receptor   422 aa 390 aa 33.6 %
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit Serotonin 3 (5-HT3) receptor   483 aa 482 aa 23.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0268 0.217 0.217
Echinococcus granulosus sex peptide receptor 0.0268 0.217 0.217
Loa Loa (eye worm) hypothetical protein 0.0268 0.217 0.217
Echinococcus granulosus neuropeptide receptor 0.0268 0.217 0.217
Toxoplasma gondii subtilisin SUB11 0.0054 0.0338 0.2598
Echinococcus granulosus discoidin domain containing receptor 2 0.0018 0.0024 0.0024
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0054 0.0338 0.0552
Echinococcus multilocularis Tubulin beta 2C chain 0.0159 0.1232 0.1561
Loa Loa (eye worm) hypothetical protein 0.0097 0.07 0.07
Trypanosoma cruzi beta tubulin, putative 0.0159 0.1232 1
Schistosoma mansoni discoidin domain receptor 0.0018 0.0024 0.0024
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0054 0.0338 0.0338
Echinococcus granulosus glycine receptor subunit alpha 1 0.0015 0.0001 0.0001
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0268 0.217 0.217
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0036 0.0178 0.0178
Echinococcus granulosus G protein coupled receptor 139 0.0268 0.217 0.217
Echinococcus granulosus rhodopsin orphan GPCR 0.0268 0.217 0.217
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0024 0.0039
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0024 0.0039
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0018 0.0024 0.0039
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0268 0.217 0.217
Schistosoma mansoni hypothetical protein 0.0268 0.217 0.217
Onchocerca volvulus 0.0029 0.0119 0.0264
Echinococcus multilocularis rhodopsin orphan GPCR 0.0268 0.217 0.2749
Echinococcus granulosus tachykinin peptides receptor 99D 0.0268 0.217 0.217
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0268 0.217 0.217
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.0054 0.0338 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0268 0.217 0.2749
Schistosoma mansoni site-1 peptidase (S08 family) 0.0054 0.0338 0.0338
Trichomonas vaginalis conserved hypothetical protein 0.0246 0.1979 0.3233
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0268 0.217 0.217
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0054 0.0338 0.0552
Onchocerca volvulus 0.0021 0.0051 0.0113
Plasmodium falciparum subtilisin-like protease 2 0.0054 0.0338 0.2598
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0039 0.0209 0.0209
Echinococcus granulosus glycine receptor subunit beta 0.0015 0.0001 0.0001
Onchocerca volvulus 0.0015 0.0001 0.0002
Giardia lamblia Beta tubulin 0.0159 0.1232 0.3473
Echinococcus multilocularis tyrosine protein kinase Srms 0.0036 0.0178 0.0226
Loa Loa (eye worm) hypothetical protein 0.0268 0.217 0.217
Echinococcus multilocularis beta tubulin 0.0159 0.1232 0.1561
Echinococcus multilocularis membrane bound transcription factor site 1 0.0054 0.0338 0.0428
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0268 0.217 0.2749
Brugia malayi putative neuropeptide receptor NPR1 0.0268 0.217 0.217
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0024 0.0039
Echinococcus granulosus tyrosine protein kinase Src42A 0.0039 0.0209 0.0209
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0015 0.0001 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0246 0.1979 0.3233
Brugia malayi AKH receptor 0.0268 0.217 0.217
Echinococcus granulosus Tubulin beta 2C chain 0.0159 0.1232 0.1232
Onchocerca volvulus 0.0268 0.217 0.4822
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0268 0.217 0.217
Echinococcus granulosus epidermal growth factor receptor 0.014 0.1073 0.1073
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0015 0.0001 0.0001
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0054 0.0338 0.0552
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0039 0.0209 0.0265
Brugia malayi hypothetical protein 0.0268 0.217 0.217
Echinococcus granulosus g protein coupled receptor 0.0268 0.217 0.217
Onchocerca volvulus 0.0268 0.217 0.4822
Echinococcus granulosus discoidin domain containing receptor 2 0.0018 0.0024 0.0024
Echinococcus granulosus rhodopsin orphan GPCR 0.0268 0.217 0.217
Echinococcus multilocularis ephrin type A receptor 4 A 0.0193 0.1526 0.1933
Loa Loa (eye worm) G-protein coupled receptor 0.0268 0.217 0.217
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0268 0.217 0.217
Echinococcus granulosus discoidin domain receptor 0.0018 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0268 0.217 0.217
Echinococcus granulosus 7tm_1 domain containing protein 0.0268 0.217 0.217
Loa Loa (eye worm) hypothetical protein 0.0268 0.217 0.217
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.0054 0.0338 0.5
Onchocerca volvulus 0.0268 0.217 0.4822
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0268 0.217 0.217
Schistosoma mansoni tyrosine kinase 0.0039 0.0209 0.0209
Loa Loa (eye worm) G-protein coupled receptor 0.0268 0.217 0.217
Loa Loa (eye worm) hypothetical protein 0.0268 0.217 0.217
Onchocerca volvulus 0.0268 0.217 0.4822
Loa Loa (eye worm) TK/EPH protein kinase 0.0245 0.1972 0.1972
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.0246 0.1979 0.3233
Toxoplasma gondii subtilisin SUB2 0.0054 0.0338 0.2598
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0054 0.0338 1
Onchocerca volvulus 0.0015 0.0001 0.0002
Brugia malayi excitatory GABA receptor EXP-1A 0.0015 0.0001 0.0001
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0015 0.0001 0.0001
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0023 0.0069 0.0069
Schistosoma mansoni growth hormone secretagogue receptor 0.0268 0.217 0.217
Schistosoma mansoni discoidin domain receptor 0.0018 0.0024 0.0024
Echinococcus granulosus tm gpcr rhodopsin 0.0268 0.217 0.217
Brugia malayi Serotonin receptor 0.0268 0.217 0.217
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0015 0.0001 0.0001
Echinococcus multilocularis G protein coupled receptor 139 0.0268 0.217 0.2749
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0054 0.0338 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0001 0.0001
Leishmania major beta tubulin 0.0159 0.1232 1
Schistosoma mansoni tubulin subunit beta 0.0159 0.1232 0.1232
Trichomonas vaginalis tubulin, putative 0.0159 0.1232 0.2013
Echinococcus granulosus neuropeptides capa receptor 0.0268 0.217 0.217
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0024 0.0039
Echinococcus granulosus somatostatin receptor 0.0268 0.217 0.217
Onchocerca volvulus 0.0541 0.45 1
Giardia lamblia Furin precursor putative serine protease 0.0246 0.1979 0.5577
Echinococcus granulosus allatostatin A receptor 0.0541 0.45 0.45
Schistosoma mansoni neuropeptide receptor 0.0268 0.217 0.217
Toxoplasma gondii subtilisin SUB10 0.0054 0.0338 0.2598
Echinococcus multilocularis nuclear receptor 2C2 associated protein 0.0018 0.0024 0.003
Echinococcus granulosus Tubulin beta 2C chain 0.0159 0.1232 0.1232
Loa Loa (eye worm) hypothetical protein 0.0015 0.0001 0.0001
Plasmodium vivax subtilisin-like protease 2, putative 0.0054 0.0338 0.2598
Leishmania major beta tubulin 0.0159 0.1232 1
Brugia malayi hypothetical protein 0.0268 0.217 0.217
Echinococcus granulosus tyrosine protein kinase Fyn 0.0039 0.0209 0.0209
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.0246 0.1979 0.3233
Leishmania major beta tubulin 0.0159 0.1232 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0268 0.217 0.2749
Schistosoma mansoni hypothetical protein 0.0023 0.0066 0.0066
Echinococcus granulosus orexin receptor type 2 0.0268 0.217 0.217
Loa Loa (eye worm) hypothetical protein 0.0268 0.217 0.217
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0015 0.0001 0.0001
Echinococcus multilocularis nAChR subunit 0.0015 0.0001 0.0001
Brugia malayi Protein kinase domain containing protein 0.0021 0.0051 0.0051
Echinococcus granulosus neuropeptide Y receptor 0.0268 0.217 0.217
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0054 0.0338 0.0552
Echinococcus multilocularis Tubulin beta 2C chain 0.0159 0.1232 0.1561
Mycobacterium leprae Possible secreted protease 0.0054 0.0338 1
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0268 0.217 0.4822
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0175 0.1368 0.1368
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0054 0.0338 0.0552
Onchocerca volvulus 0.019 0.1499 0.3331
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.03 0.2444 0.3994
Schistosoma mansoni neuropeptide F-like receptor 0.0268 0.217 0.217
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0541 0.45 0.45
Echinococcus multilocularis dnaJ subfamily B 0.0816 0.6856 0.8685
Schistosoma mansoni tubulin subunit beta 0.0159 0.1232 0.1232
Echinococcus multilocularis neuropeptide FF receptor 2 0.0268 0.217 0.2749
Echinococcus multilocularis dro:myosuppressin receptor 0.0268 0.217 0.2749
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0054 0.0338 0.0428
Plasmodium vivax protein kinase, putative 0.0018 0.0027 0.0027
Echinococcus granulosus tubulin beta 1 chain 0.0159 0.1232 0.1232
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.03 0.2444 0.3994
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0015 0.0001 0.0001
Echinococcus multilocularis neuropeptide receptor 0.0268 0.217 0.2749
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0054 0.0338 0.0552
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0268 0.217 0.2749
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0039 0.0209 0.0265
Brugia malayi neuroendocrine convertase 1 precursor 0.0754 0.6324 0.6324
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0024
Toxoplasma gondii beta-1 tubulin, putative 0.0159 0.1232 1
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0268 0.217 0.217
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0065 0.0427 0.2665
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0054 0.0338 0.0338
Brugia malayi Furin-like cysteine rich region family protein 0.014 0.1073 0.1073
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0268 0.217 0.217
Loa Loa (eye worm) hypothetical protein 0.0268 0.217 0.217
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 32 0.0019 0.0033 0.0033
Trichomonas vaginalis hypothetical protein 0.0018 0.0024 0.0039
Schistosoma mansoni hypothetical protein 0.0268 0.217 0.217
Giardia lamblia Beta tubulin 0.0159 0.1232 0.3473
Loa Loa (eye worm) TK/EGFR protein kinase 0.014 0.1073 0.1073
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0268 0.217 0.217
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.073 0.612 0.612
Echinococcus granulosus rhodopsin orphan GPCR 0.0268 0.217 0.217
Onchocerca volvulus 0.0015 0.0001 0.0002
Schistosoma mansoni amine GPCR 0.0268 0.217 0.217
Loa Loa (eye worm) hypothetical protein 0.0268 0.217 0.217
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0024 0.0039
Echinococcus granulosus membrane bound transcription factor site 1 0.0054 0.0338 0.0338
Trichomonas vaginalis conserved hypothetical protein 0.0246 0.1979 0.3233
Loa Loa (eye worm) beta-tubulin 0.0159 0.1232 0.1232
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0024 0.0039
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.073 0.612 0.7753
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0268 0.217 0.217
Echinococcus multilocularis neuropeptide Y receptor 0.0268 0.217 0.2749
Loa Loa (eye worm) hypothetical protein 0.0015 0.0001 0.0001
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0015 0.0001 0.0001
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0268 0.217 0.2749
Echinococcus multilocularis rhodopsin orphan GPCR 0.0268 0.217 0.2749
Toxoplasma gondii beta tubulin 0.0159 0.1232 1
Brugia malayi hypothetical protein 0.0268 0.217 0.217
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0015 0.0001 0.0001
Toxoplasma gondii subtilisin SUB6 0.0054 0.0338 0.2598
Loa Loa (eye worm) hypothetical protein 0.0015 0.0001 0.0001
Toxoplasma gondii subtilisin SUB1 0.0054 0.0338 0.2598
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0054 0.0338 0.0552
Echinococcus granulosus biogenic amine 5HT receptor 0.0268 0.217 0.217
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0268 0.217 0.2749
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0015 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0268 0.217 0.217
Schistosoma mansoni nAChR subunit 0.0015 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.0018 0.0024 0.0024
Echinococcus multilocularis g protein coupled receptor 0.0268 0.217 0.2749
Trichomonas vaginalis conserved hypothetical protein 0.0246 0.1979 0.3233
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0015 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0268 0.217 0.217
Onchocerca volvulus 0.0015 0.0001 0.0002
Echinococcus multilocularis orexin receptor type 2 0.0268 0.217 0.2749
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0338 0.0552
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0268 0.217 0.2749
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0015 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0268 0.217 0.217
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0268 0.217 0.217
Brugia malayi G-protein coupled receptor 0.0268 0.217 0.217
Schistosoma mansoni tubulin subunit beta 0.0159 0.1232 0.1232
Loa Loa (eye worm) hypothetical protein 0.0015 0.0001 0.0001
Loa Loa (eye worm) melatonin receptor type 1A 0.0268 0.217 0.217
Brugia malayi sulfakinin receptor protein 0.0268 0.217 0.217
Loa Loa (eye worm) hypothetical protein 0.0268 0.217 0.217
Echinococcus multilocularis Tubulin beta 2C chain 0.0159 0.1232 0.1561
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0065 0.0427 0.3468
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0054 0.0338 0.0552
Echinococcus granulosus neuropeptides capa receptor 0.0268 0.217 0.217
Leishmania major beta tubulin 0.0159 0.1232 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0268 0.217 0.217
Echinococcus granulosus tubulin beta 4A class IVa 0.0159 0.1232 0.1232
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0268 0.217 0.2749
Loa Loa (eye worm) hypothetical protein 0.0015 0.0001 0.0001
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0054 0.0338 0.0552
Brugia malayi GnHR receptor homolog 0.0268 0.217 0.217
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0015 0.0001 0.0001
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0054 0.0338 0.0552
Echinococcus granulosus 7TM GPCR rhodopsin 0.0268 0.217 0.217
Loa Loa (eye worm) hypothetical protein 0.0268 0.217 0.217
Schistosoma mansoni site-1 peptidase (S08 family) 0.0054 0.0338 0.0338
Echinococcus multilocularis neuroendocrine convertase 2 0.0754 0.6324 0.8012
Trichomonas vaginalis hypothetical protein 0.0246 0.1979 0.3233
Echinococcus multilocularis g protein coupled receptor 0.0268 0.217 0.2749
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0039 0.0209 0.0209
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.1183 1 1
Brugia malayi ephrin receptor 1 precursor 0.0093 0.0666 0.0666
Onchocerca volvulus 0.0268 0.217 0.4822
Giardia lamblia High cysteine membrane protein Group 2 0.0429 0.3548 1
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0015 0.0001 0.0001
Schistosoma mansoni neuropeptide receptor 0.0268 0.217 0.217
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0015 0.0001 0.0001
Echinococcus multilocularis neuropeptides capa receptor 0.0268 0.217 0.2749
Trypanosoma brucei beta tubulin 0.0159 0.1232 0.7684
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0015 0.0001 0.0001
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.073 0.612 1
Loa Loa (eye worm) tubulin beta-1 chain 0.0159 0.1232 0.1232
Brugia malayi larval opioid receptor 0.0268 0.217 0.217
Loa Loa (eye worm) hypothetical protein 0.0019 0.0033 0.0033
Echinococcus granulosus tyrosine protein kinase Src42A 0.0033 0.0151 0.0151
Schistosoma mansoni amine GPCR 0.0268 0.217 0.217
Echinococcus multilocularis rhodopsin orphan GPCR 0.0268 0.217 0.2749
Leishmania major beta tubulin 0.0159 0.1232 1
Loa Loa (eye worm) hypothetical protein 0.0268 0.217 0.217
Plasmodium falciparum subtilisin-like protease 1 0.0054 0.0338 0.2598
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0175 0.1368 0.1368
Brugia malayi RE15519p 0.0268 0.217 0.217
Loa Loa (eye worm) hypothetical protein 0.0268 0.217 0.217
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0054 0.0338 1
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0015 0.0001 0.0001
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.0054 0.0338 0.5
Trypanosoma brucei beta tubulin 0.0159 0.1232 0.7684
Loa Loa (eye worm) hypothetical protein 0.0015 0.0001 0.0001
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0015 0.0001 0.0001
Onchocerca volvulus 0.0015 0.0001 0.0002
Leishmania major beta tubulin 0.0159 0.1232 1
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0024 0.0039
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0268 0.217 0.217
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0039 0.0209 0.0265
Brugia malayi Serotonin receptor 0.0268 0.217 0.217
Brugia malayi G protein-coupled receptor 0.0268 0.217 0.217
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0054 0.0338 0.0552
Echinococcus multilocularis tyrosine protein kinase Blk 0.0036 0.0178 0.0226
Echinococcus multilocularis G-protein coupled receptor, putative 0.0268 0.217 0.2749
Entamoeba histolytica tubulin family protein 0.0159 0.1232 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0268 0.217 0.217
Schistosoma mansoni neuropeptide receptor 0.0268 0.217 0.217
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0024 0.0039
Echinococcus granulosus nAChR subunit 0.0015 0.0001 0.0001
Echinococcus granulosus g-protein coupled receptor 0.0268 0.217 0.217
Loa Loa (eye worm) hypothetical protein 0.0268 0.217 0.217
Echinococcus multilocularis discoidin domain receptor 0.0018 0.0024 0.003
Echinococcus multilocularis neuropeptide receptor 0.0268 0.217 0.2749
Loa Loa (eye worm) endoprotease bli-4 0.1183 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0268 0.217 0.2749
Echinococcus granulosus beta tubulin 0.0159 0.1232 0.1232
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0268 0.217 0.217
Trypanosoma brucei subtilisin peptidase 0.0054 0.0338 0.2106
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.03 0.2444 0.3994
Brugia malayi hypothetical protein 0.0268 0.217 0.217
Trichomonas vaginalis beta-hexosaminidase B, putative 0.0018 0.0024 0.0039
Leishmania major beta tubulin 0.0159 0.1232 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0001 0.0001
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0036 0.0178 0.0226
Echinococcus granulosus tm gpcr rhodopsin 0.0268 0.217 0.217
Plasmodium falciparum subtilisin-like protease 3 0.0054 0.0338 0.2598
Loa Loa (eye worm) hypothetical protein 0.0015 0.0001 0.0001
Echinococcus multilocularis Furin 1 0.03 0.2444 0.3096
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0268 0.217 0.217
Echinococcus multilocularis g protein coupled receptor 0.0268 0.217 0.2749
Loa Loa (eye worm) hypothetical protein 0.0268 0.217 0.217
Brugia malayi celfurPC protein 0.0937 0.7894 0.7894
Trichomonas vaginalis conserved hypothetical protein 0.0246 0.1979 0.3233
Brugia malayi proprotein convertase 2 0.0754 0.6324 0.6324
Schistosoma mansoni nAChR subunit 0.0015 0.0001 0.0001
Brugia malayi putative neuropeptide receptor 0.0268 0.217 0.217
Onchocerca volvulus 0.0268 0.217 0.4822
Echinococcus multilocularis epidermal growth factor receptor 0.014 0.1073 0.136
Schistosoma mansoni hypothetical protein 0.0202 0.1604 0.1604
Loa Loa (eye worm) hypothetical protein 0.0268 0.217 0.217
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.0054 0.0338 0.274
Schistosoma mansoni hypothetical protein 0.0246 0.1979 0.1979
Echinococcus multilocularis Coagulation factor 5 8 type, C terminal 0.0018 0.0024 0.003
Echinococcus granulosus glycine receptor subunit alpha 1 0.0015 0.0001 0.0001
Echinococcus granulosus Tubulin beta 2C chain 0.0159 0.1232 0.1232
Onchocerca volvulus 0.0268 0.217 0.4822
Leishmania major beta tubulin 0.0159 0.1232 1
Leishmania major beta tubulin 0.0159 0.1232 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0023 0.0069 0.0069
Loa Loa (eye worm) hypothetical protein 0.0019 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0015 0.0001 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0338 0.0552
Schistosoma mansoni myosin xvIII 0.0268 0.217 0.217
Trichomonas vaginalis tubulin alpha chain, putative 0.0159 0.1232 0.2013
Loa Loa (eye worm) LGC-31 protein 0.0015 0.0001 0.0001
Schistosoma mansoni tubulin subunit beta 0.0159 0.1232 0.1232
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0024 0.0039
Brugia malayi Protein kinase domain containing protein 0.0026 0.0093 0.0093
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0039 0.0209 0.0265
Loa Loa (eye worm) hypothetical protein 0.0268 0.217 0.217
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0338 0.0552
Schistosoma mansoni nAChR subunit 0.0015 0.0001 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0338 0.0552
Schistosoma mansoni amine GPCR 0.0268 0.217 0.217
Leishmania major beta tubulin 0.0159 0.1232 1
Echinococcus granulosus Tubulin beta 2C chain 0.0159 0.1232 0.1232
Brugia malayi hypothetical protein 0.0268 0.217 0.217
Loa Loa (eye worm) hypothetical protein 0.0268 0.217 0.217
Echinococcus granulosus ephrin type A receptor 4 A 0.0193 0.1526 0.1526
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0054 0.0338 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0015 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0015 0.0001 0.0001
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0175 0.1368 0.1733
Leishmania major beta tubulin 0.0159 0.1232 1
Onchocerca volvulus Putative nachr subunit 0.0015 0.0001 0.0002
Echinococcus multilocularis discoidin domain containing receptor 2 0.0018 0.0024 0.003
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0015 0.0001 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0246 0.1979 0.3233
Loa Loa (eye worm) hypothetical protein 0.0268 0.217 0.217
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0054 0.0338 1
Brugia malayi neuropeptide F receptor 0.0268 0.217 0.217
Echinococcus granulosus MAM 0.0023 0.0066 0.0066
Loa Loa (eye worm) subtilase 0.0054 0.0338 0.0338
Echinococcus granulosus tyrosine protein kinase Src64B 0.0039 0.0209 0.0209
Schistosoma mansoni nAChR subunit 0.0015 0.0001 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0246 0.1979 0.3233
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0065 0.0427 0.3468
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.073 0.612 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0268 0.217 0.217
Echinococcus granulosus tyrosine protein kinase Lyn 0.004 0.0213 0.0213
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0015 0.0001 0.0001
Echinococcus multilocularis neuropeptide s receptor 0.0268 0.217 0.2749
Schistosoma mansoni tyrosine kinase 0.0039 0.0209 0.0209
Onchocerca volvulus 0.0268 0.217 0.4822
Echinococcus granulosus tyrosine protein kinase Blk 0.0036 0.0178 0.0178
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0268 0.217 0.2749
Echinococcus granulosus peptide allatostatin:somatostatin 0.0268 0.217 0.217
Onchocerca volvulus 0.0268 0.217 0.4822
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0015 0.0001 0.0001
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0033 0.0151 0.0192
Echinococcus multilocularis g-protein coupled receptor 0.0268 0.217 0.2749
Brugia malayi hypothetical protein 0.0023 0.0066 0.0066
Brugia malayi hypothetical protein 0.0268 0.217 0.217
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0268 0.217 0.217
Loa Loa (eye worm) tubulin beta-2A chain 0.0159 0.1232 0.1232
Loa Loa (eye worm) hypothetical protein 0.0268 0.217 0.217
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0268 0.217 0.217
Schistosoma mansoni biogenic amine receptor 0.0268 0.217 0.217
Loa Loa (eye worm) proprotein convertase 2 0.03 0.2444 0.2444
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0015 0.0001 0.0001
Echinococcus granulosus rhodopsin orphan GPCR 0.0268 0.217 0.217
Echinococcus multilocularis tubulin beta 1 chain 0.0159 0.1232 0.1561
Echinococcus granulosus neuropeptide receptor 0.0268 0.217 0.217
Onchocerca volvulus 0.003 0.0128 0.0283
Brugia malayi map kinase activated protein kinase protein 2 0.0175 0.1368 0.1368
Toxoplasma gondii subtilisin SUB9 0.0054 0.0338 0.2598
Loa Loa (eye worm) hypothetical protein 0.0268 0.217 0.217
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0268 0.217 0.217
Echinococcus multilocularis fmrfamide receptor 0.0268 0.217 0.2749
Schistosoma mansoni opsin-like receptor 0.0268 0.217 0.217
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0268 0.217 0.217
Trichomonas vaginalis tubulin epsilon chain, putative 0.0159 0.1232 0.2013
Schistosoma mansoni amine GPCR 0.0268 0.217 0.217
Schistosoma mansoni adenoreceptor 0.0268 0.217 0.217
Echinococcus granulosus beta tubulin 0.0159 0.1232 0.1232
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0015 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0453 0.3752 0.3752
Onchocerca volvulus 0.0268 0.217 0.4822
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0268 0.217 0.217
Loa Loa (eye worm) BEN-1 protein 0.0159 0.1232 0.1232
Brugia malayi hypothetical protein 0.0268 0.217 0.217
Brugia malayi neuropeptide F receptor 0.0268 0.217 0.217
Schistosoma mansoni opsin-like receptor 0.0268 0.217 0.217
Toxoplasma gondii subtilisin SUB7 0.0054 0.0338 0.2598
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0268 0.217 0.217
Schistosoma mansoni opsin-like receptor 0.0268 0.217 0.217
Brugia malayi follicle stimulating hormone receptor 0.0268 0.217 0.217
Brugia malayi Dopamine receptor protein 1 0.0268 0.217 0.217
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0054 0.0338 0.0552
Loa Loa (eye worm) hypothetical protein 0.0015 0.0001 0.0001
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0018 0.0024 0.0039
Schistosoma mansoni hypothetical protein 0.0023 0.0066 0.0066
Loa Loa (eye worm) TK protein kinase 0.0036 0.0178 0.0178
Brugia malayi Dopamine receptor 0.0268 0.217 0.217
Loa Loa (eye worm) hypothetical protein 0.0015 0.0001 0.0001
Brugia malayi hypothetical protein 0.0268 0.217 0.217
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0054 0.0338 0.0552
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0268 0.217 0.217
Loa Loa (eye worm) hypothetical protein 0.0268 0.217 0.217
Loa Loa (eye worm) TK protein kinase 0.0032 0.0146 0.0146
Echinococcus granulosus tubulin subunit beta 0.0159 0.1232 0.1232
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0039 0.0209 0.0265
Leishmania major beta tubulin 0.0159 0.1232 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0001 0.0001
Brugia malayi Cation transporter family protein 0.0015 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.0816 0.6856 0.6856
Loa Loa (eye worm) hypothetical protein 0.0268 0.217 0.217
Loa Loa (eye worm) hypothetical protein 0.0015 0.0001 0.0001
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0268 0.217 0.217
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0015 0.0001 0.0001
Toxoplasma gondii subtilisin SUB8 0.0054 0.0338 0.2598
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0268 0.217 0.2749
Echinococcus multilocularis somatostatin receptor 0.0268 0.217 0.2749
Onchocerca volvulus Neuropeptide F receptor homolog 0.0268 0.217 0.4822
Brugia malayi Dopamine receptor protein 2 0.0268 0.217 0.217
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0268 0.217 0.217
Echinococcus granulosus hypothetical protein 0.0268 0.217 0.217
Trichomonas vaginalis tubulin gamma chain, putative 0.0159 0.1232 0.2013
Loa Loa (eye worm) hypothetical protein 0.019 0.1499 0.1499
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0015 0.0001 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0246 0.1979 0.3233
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0015 0.0001 0.0001
Loa Loa (eye worm) BEN-1 protein 0.0159 0.1232 0.1232
Leishmania major beta tubulin 0.0159 0.1232 1
Echinococcus multilocularis glycine receptor subunit beta 0.0015 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0268 0.217 0.217
Plasmodium falciparum tubulin beta chain 0.0159 0.1232 1
Loa Loa (eye worm) TYRA-2 protein 0.0268 0.217 0.217
Schistosoma mansoni furin-1 (S08 family) 0.0508 0.4218 0.4218
Loa Loa (eye worm) hypothetical protein 0.0268 0.217 0.217
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0054 0.0338 0.0552
Schistosoma mansoni tubulin subunit beta 0.0159 0.1232 0.1232
Loa Loa (eye worm) hypothetical protein 0.0268 0.217 0.217
Echinococcus granulosus Furin 1 0.03 0.2444 0.2444
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0054 0.0338 0.0552
Schistosoma mansoni serine/threonine protein kinase 0.0175 0.1368 0.1368
Schistosoma mansoni hypothetical protein 0.0268 0.217 0.217
Schistosoma mansoni biogenic amine (5HT) receptor 0.0416 0.3429 0.3429
Echinococcus granulosus neuropeptide receptor A26 0.0268 0.217 0.217
Toxoplasma gondii subtilisin SUB4 0.0054 0.0338 0.2598
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0015 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0268 0.217 0.217
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0024 0.0039
Loa Loa (eye worm) ACC-1 protein 0.0015 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0268 0.217 0.217
Brugia malayi Tubulin beta-1 chain 0.0159 0.1232 0.1232
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0015 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.0268 0.217 0.217
Toxoplasma gondii subtilisin SUB5 0.0054 0.0338 0.2598
Schistosoma mansoni neuropeptide receptor 0.0268 0.217 0.217
Loa Loa (eye worm) hypothetical protein 0.1183 1 1
Echinococcus granulosus dnaJ subfamily B 0.0816 0.6856 0.6856
Schistosoma mansoni histamine h1 receptor 0.0268 0.217 0.217
Trichomonas vaginalis tubulin beta chain, putative 0.0159 0.1232 0.2013
Onchocerca volvulus 0.0268 0.217 0.4822
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.03 0.2444 0.2444
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0268 0.217 0.2749
Schistosoma mansoni neuropeptide F-like receptor 0.0268 0.217 0.217
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0268 0.217 0.2749
Leishmania major beta tubulin 0.0159 0.1232 1
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0015 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0268 0.217 0.217
Echinococcus multilocularis Tubulin beta 2C chain 0.0159 0.1232 0.1561
Schistosoma mansoni dock 0.0018 0.0024 0.0024
Echinococcus granulosus tyrosine protein kinase Fyn 0.0039 0.0209 0.0209
Brugia malayi SRC-1 0.0039 0.0209 0.0209
Echinococcus granulosus rhodopsin orphan GPCR 0.0268 0.217 0.217
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0268 0.217 0.217
Brugia malayi Cation transporter family protein 0.0015 0.0001 0.0001
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0015 0.0001 0.0001
Echinococcus granulosus rhodopsin orphan GPCR 0.0268 0.217 0.217
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0054 0.0338 0.0552
Echinococcus granulosus tyrosine protein kinase Fyn 0.0039 0.0209 0.0209
Echinococcus granulosus g protein coupled receptor 0.0268 0.217 0.217
Loa Loa (eye worm) hypothetical protein 0.0268 0.217 0.217
Brugia malayi G protein-coupled receptor F59B2.13 0.0268 0.217 0.217
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0268 0.217 0.217
Toxoplasma gondii subtilisin SUB12 0.0054 0.0338 0.2598
Loa Loa (eye worm) hypothetical protein 0.0028 0.0113 0.0113
Onchocerca volvulus 0.0054 0.0338 0.075
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0024 0.0039
Loa Loa (eye worm) hypothetical protein 0.0268 0.217 0.217
Loa Loa (eye worm) neuropeptide F receptor 0.0268 0.217 0.217
Echinococcus multilocularis neuropeptides capa receptor 0.0268 0.217 0.2749
Loa Loa (eye worm) hypothetical protein 0.0023 0.0066 0.0066
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0268 0.217 0.217
Echinococcus multilocularis tyrosine protein kinase HCK 0.0032 0.0146 0.0185
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0024 0.0039
Brugia malayi Subtilase family protein 0.0054 0.0338 0.0338
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0054 0.0338 1
Loa Loa (eye worm) hypothetical protein 0.0268 0.217 0.217
Loa Loa (eye worm) hypothetical protein 0.0268 0.217 0.217
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0054 0.0338 0.0552
Loa Loa (eye worm) hypothetical protein 0.0268 0.217 0.217
Schistosoma mansoni neuropeptide f receptor 76f 0.0268 0.217 0.217
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0268 0.217 0.217
Echinococcus granulosus glycine receptor subunit beta 0.0015 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0416 0.3429 0.3429
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0268 0.217 0.2749
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0268 0.217 0.217
Loa Loa (eye worm) hypothetical protein 0.0416 0.3429 0.3429
Brugia malayi protein-tyrosine kinase 0.0036 0.0178 0.0178
Schistosoma mansoni nAChR subunit 0.0015 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0015 0.0001 0.0001
Onchocerca volvulus 0.0015 0.0001 0.0002
Schistosoma mansoni biogenic amine receptor 0.0268 0.217 0.217
Echinococcus granulosus rhodopsin orphan GPCR 0.0268 0.217 0.217
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0015 0.0001 0.0001
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0054 0.0338 0.0338
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0015 0.0001 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0246 0.1979 0.3233
Schistosoma mansoni tyrosine kinase 0.014 0.1073 0.1073
Loa Loa (eye worm) hypothetical protein 0.0268 0.217 0.217
Echinococcus granulosus alpha 1A adrenergic receptor 0.0268 0.217 0.217
Onchocerca volvulus 0.0023 0.0066 0.0147
Echinococcus granulosus serotonin receptor 0.0268 0.217 0.217
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0338 0.0552
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0054 0.0338 0.0552
Onchocerca volvulus 0.0268 0.217 0.4822
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0024
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0054 0.0338 0.0338
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0268 0.217 0.217
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.0246 0.1979 0.3233
Echinococcus multilocularis glycine receptor subunit beta 0.0015 0.0001 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0246 0.1979 0.3233
Onchocerca volvulus 0.0018 0.0024 0.0053
Schistosoma mansoni amine GPCR 0.0268 0.217 0.217
Onchocerca volvulus 0.0268 0.217 0.4822
Echinococcus granulosus neuropeptide Y receptor 0.0268 0.217 0.217
Trypanosoma brucei beta tubulin 0.0159 0.1232 0.7684
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0015 0.0001 0.0001
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0054 0.0338 0.0552
Leishmania major beta tubulin 0.0159 0.1232 1
Leishmania major beta tubulin 0.0159 0.1232 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0001 0.0001
Echinococcus granulosus neuroendocrine convertase 2 0.0754 0.6324 0.6324
Leishmania major beta tubulin 0.0159 0.1232 1
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0015 0.0001 0.0001
Brugia malayi Melatonin receptor type 1A 0.0268 0.217 0.217
Onchocerca volvulus 0.0268 0.217 0.4822
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0015 0.0001 0.0001
Giardia lamblia Beta tubulin 0.0159 0.1232 0.3473
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0054 0.0338 0.0338
Echinococcus granulosus Coagulation factor 5 8 type C terminal 0.0018 0.0024 0.0024
Echinococcus granulosus discoidin domain containing receptor 2 0.0018 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0268 0.217 0.217
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0039 0.0209 0.0265
Echinococcus multilocularis rhodopsin orphan GPCR 0.0268 0.217 0.2749
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0015 0.0001 0.0001
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0039 0.0209 0.0265
Onchocerca volvulus 0.0268 0.217 0.4822
Echinococcus multilocularis serotonin receptor 0.0416 0.3429 0.4344
Echinococcus multilocularis rhodopsin orphan GPCR 0.0268 0.217 0.2749
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0054 0.0338 0.0552
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0015 0.0001 0.0001
Entamoeba histolytica tubulin family protein 0.0159 0.1232 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0268 0.217 0.217
Trypanosoma brucei RNA helicase, putative 0.0202 0.1604 1
Schistosoma mansoni ephrin receptor 0.0193 0.1526 0.1526
Brugia malayi hypothetical protein 0.0268 0.217 0.217
Brugia malayi beta-tubulin, identical 0.0159 0.1232 0.1232
Schistosoma mansoni biogenic amine (5HT) receptor 0.0268 0.217 0.217
Plasmodium vivax subtilisin-like serine protease, putative 0.0054 0.0338 0.2598
Loa Loa (eye worm) hypothetical protein 0.0268 0.217 0.217
Schistosoma mansoni septate junction protein 0.0018 0.0024 0.0024
Echinococcus granulosus dro:myosuppressin receptor 0.0268 0.217 0.217
Loa Loa (eye worm) neuropeptide F receptor 0.0268 0.217 0.217
Loa Loa (eye worm) hypothetical protein 0.0015 0.0001 0.0001
Echinococcus multilocularis beta tubulin 0.0159 0.1232 0.1561
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 30. 0.0019 0.0033 0.0033
Toxoplasma gondii beta-tubulin, putative 0.0159 0.1232 1
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0159 0.1232 0.1561
Loa Loa (eye worm) hypothetical protein 0.0054 0.0338 0.0338
Onchocerca volvulus 0.0268 0.217 0.4822
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0015 0.0001 0.0001
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0268 0.217 0.217
Echinococcus multilocularis MAM 0.0023 0.0066 0.0084
Echinococcus multilocularis neuropeptide Y receptor 0.0268 0.217 0.2749
Echinococcus multilocularis 0.0937 0.7894 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0054 0.0338 0.0552
Leishmania major beta tubulin 0.0159 0.1232 1
Loa Loa (eye worm) hypothetical protein 0.0268 0.217 0.217
Echinococcus multilocularis fmrfamide receptor 0.0268 0.217 0.2749
Loa Loa (eye worm) hypothetical protein 0.0541 0.45 0.45
Loa Loa (eye worm) SRC-1 0.0039 0.0209 0.0209
Loa Loa (eye worm) hypothetical protein 0.0015 0.0001 0.0001
Plasmodium vivax subtilisin-like protease 1 0.0054 0.0338 0.2598
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0015 0.0001 0.0001
Schistosoma mansoni nAChR subunit 0.0015 0.0001 0.0001
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0268 0.217 0.2749
Loa Loa (eye worm) tubulin beta chain 0.0159 0.1232 0.1232
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0024 0.0039
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0015 0.0001 0.0001
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0268 0.217 0.217
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.03 0.2444 0.3994
Trichomonas vaginalis tubulin epsilon chain, putative 0.0159 0.1232 0.2013
Loa Loa (eye worm) hypothetical protein 0.0023 0.0066 0.0066
Echinococcus multilocularis neuropeptide receptor A26 0.0268 0.217 0.2749
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0268 0.217 0.2749
Echinococcus multilocularis discoidin domain containing receptor 2 0.0018 0.0024 0.003
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0015 0.0001 0.0001
Plasmodium vivax tubulin beta chain, putative 0.0159 0.1232 1
Loa Loa (eye worm) hypothetical protein 0.0268 0.217 0.217
Loa Loa (eye worm) tubulin beta-4 chain 0.0159 0.1232 0.1232
Echinococcus granulosus neuropeptide s receptor 0.0268 0.217 0.217
Echinococcus granulosus Tubulin beta 2C chain 0.0159 0.1232 0.1232
Loa Loa (eye worm) hypothetical protein 0.0268 0.217 0.217
Trichomonas vaginalis conserved hypothetical protein 0.0246 0.1979 0.3233
Loa Loa (eye worm) TK/ALK protein kinase 0.0026 0.0093 0.0093
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.03 0.2444 0.3994
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0039 0.0209 0.0265
Brugia malayi hypothetical protein 0.0268 0.217 0.217
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0015 0.0001 0.0001
Echinococcus multilocularis serotonin receptor 0.0416 0.3429 0.4344
Schistosoma mansoni biogenic amine receptor 0.0268 0.217 0.217
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0024 0.0039
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0268 0.217 0.2749
Echinococcus granulosus glycine receptor subunit alpha 1 0.0015 0.0001 0.0001
Echinococcus granulosus biogenic amine 5HT receptor 0.0416 0.3429 0.3429
Echinococcus multilocularis Tubulin beta 2C chain 0.0159 0.1232 0.1561
Echinococcus granulosus tyrosine protein kinase HCK 0.0032 0.0146 0.0146
Echinococcus granulosus fmrfamide receptor 0.0268 0.217 0.217
Echinococcus granulosus neuropeptide FF receptor 2 0.0268 0.217 0.217
Trypanosoma cruzi subtilisin peptidase 0.0054 0.0338 0.274
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0015 0.0001 0.0001
Loa Loa (eye worm) ACC-1 protein 0.0015 0.0001 0.0001
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0015 0.0001 0.0001
Echinococcus granulosus g protein coupled receptor 0.0268 0.217 0.217
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0054 0.0338 0.0552
Echinococcus multilocularis sex peptide receptor 0.0268 0.217 0.2749
Schistosoma mansoni tubulin subunit beta 0.0159 0.1232 0.1232
Echinococcus multilocularis allatostatin A receptor 0.0541 0.45 0.5701
Echinococcus granulosus tm gpcr rhodopsin 0.0268 0.217 0.217
Trypanosoma brucei beta tubulin 0.0159 0.1232 0.7684
Echinococcus granulosus tyrosine kinase 0.0036 0.0178 0.0178
Brugia malayi Cation transporter family protein 0.0015 0.0001 0.0001
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0015 0.0001 0.0001
Echinococcus multilocularis tubulin subunit beta 0.0159 0.1232 0.1561
Echinococcus multilocularis discoidin domain containing receptor 2 0.0018 0.0024 0.003
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0039 0.0209 0.0265
Schistosoma mansoni nAChR subunit 0.0015 0.0001 0.0001
Schistosoma mansoni btb and poz domain-containing protein 0.0018 0.0024 0.0024
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0015 0.0001 0.0001
Brugia malayi ORL1-like opioid receptor 0.0268 0.217 0.217
Brugia malayi Tachykinin-like peptides receptor 99D 0.0268 0.217 0.217
Brugia malayi G-protein coupled receptor 0.0268 0.217 0.217
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0054 0.0338 0.0552
Schistosoma mansoni alpha-1 adrenergic receptor 0.0268 0.217 0.217
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0054 0.0338 0.0552
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0024 0.0039
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.03 0.2444 0.3994
Loa Loa (eye worm) hypothetical protein 0.0023 0.0066 0.0066
Echinococcus granulosus furin 0.1183 1 1

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 15.1 nM Binding affinity for 5-HT3 receptor by displacement of [3H]-LY 278584 in rat cerebral cortex membranes ChEMBL. 12951088
Ki (binding) = 15.1 nM Binding affinity for 5-HT3 receptor by displacement of [3H]-LY 278584 in rat cerebral cortex membranes ChEMBL. 12951088
Ki (binding) = 45.9 nM Displacement of [3H]-8-OH-DPAT from 5-hydroxytryptamine 1A receptor of rat cerebral cortex membranes ChEMBL. 12951088
Ki (binding) = 45.9 nM Displacement of [3H]-8-OH-DPAT from 5-hydroxytryptamine 1A receptor of rat cerebral cortex membranes ChEMBL. 12951088

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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