Detailed information for compound 1783439

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 276.376 | Formula: C19H20N2
  • H donors: 0 H acceptors: 1 LogP: 3.83 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN([C@@H](c1cccc2c1cccc2)C)Cc1cccnc1
  • InChi: 1S/C19H20N2/c1-15(21(2)14-16-7-6-12-20-13-16)18-11-5-9-17-8-3-4-10-19(17)18/h3-13,15H,14H2,1-2H3/t15-/m1/s1
  • InChiKey: JSLISZQFGHPQQS-OAHLLOKOSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi diacylglycerol kinase 0.006 0.0309 0.1154
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0069 0.0362 0.0362
Trichomonas vaginalis diacylglycerol kinase, epsilon, putative 0.006 0.0309 0.101
Echinococcus granulosus DNA methyltransferase 2, putative 0.0021 0.005 0.005
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0048 0.0228 0.0228
Loa Loa (eye worm) RecQ helicase 0.0047 0.0222 0.0222
Echinococcus granulosus disco interacting protein 2 0.0041 0.0183 0.0183
Echinococcus multilocularis muscleblind protein 1 0.0149 0.0881 0.0881
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0047 0.0155
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0019 0.0043 0.0043
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0169 0.0169
Echinococcus granulosus caspase 0.0028 0.0095 0.0095
Loa Loa (eye worm) hypothetical protein 0.0018 0.0034 0.0034
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0152 0.0901 0.0901
Onchocerca volvulus Cell death protein 3 homolog 0.0028 0.0095 0.0074
Schistosoma mansoni hypothetical protein 0.0048 0.0228 0.0228
Echinococcus granulosus histone acetyltransferase KAT2B 0.014 0.0826 0.0826
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0029 0.0101 0.0101
Schistosoma mansoni sphingosine kinase A B 0.1553 1 1
Schistosoma mansoni cpg binding protein 0.0124 0.0721 0.0721
Echinococcus multilocularis geminin 0.0176 0.106 0.106
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0177 0.0904
Entamoeba histolytica diacylglycerol kinase, putative 0.006 0.0309 0.0309
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0177 0.0144
Loa Loa (eye worm) hypothetical protein 0.0028 0.0095 0.0095
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0024 0.0075 0.0075
Echinococcus granulosus ceramide kinase 0.006 0.0309 0.0309
Trypanosoma cruzi metacaspase, putative 0.0028 0.0095 0.0488
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0045 0.0208 0.0679
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.0522 0.0522
Onchocerca volvulus 0.0124 0.0721 0.2171
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0048 0.0228 0.0228
Leishmania major hypothetical protein, conserved 0.006 0.0309 0.158
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0177 0.0904
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0314 0.1955 1
Trypanosoma brucei transcription factor BTF3, putative 0.0036 0.0148 0.0756
Trypanosoma brucei ISWI complex protein 0.0016 0.002 0.01
Loa Loa (eye worm) hypothetical protein 0.0017 0.0026 0.0026
Plasmodium falciparum phosphoglycerate kinase 0.0177 0.1065 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.026 0.026
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.006 0.0309 0.101
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0069 0.0362 0.1851
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0019 0.0043 0.0043
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.008 0.0438 0.0438
Loa Loa (eye worm) latrophilin receptor protein 2 0.0048 0.0228 0.0228
Brugia malayi latrophilin 2 splice variant baaae 0.0104 0.059 0.2201
Treponema pallidum phosphoglycerate kinase 0.0177 0.1065 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0028 0.0095 0.0312
Schistosoma mansoni zinc finger protein 0.0029 0.0104 0.0104
Echinococcus granulosus transcription factor btf3 0.0036 0.0148 0.0148
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0043 0.0159
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0043 0.0221
Loa Loa (eye worm) hypothetical protein 0.0067 0.0349 0.0349
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0028 0.0095 0.0095
Plasmodium vivax hypothetical protein, conserved 0.003 0.0113 0.1061
Loa Loa (eye worm) hypothetical protein 0.0052 0.0254 0.0254
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0065 0.0338 0.1729
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0043 0.0043
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0314 0.1955 1
Plasmodium vivax SET domain protein, putative 0.0063 0.0323 0.3035
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0043 0.0043
Echinococcus multilocularis acylglycerol kinase, mitochondrial 0.006 0.0309 0.0309
Trypanosoma cruzi DNA polymerase eta, putative 0.0039 0.0169 0.0865
Brugia malayi Bromodomain containing protein 0.0087 0.0479 0.1786
Loa Loa (eye worm) acetyltransferase 0.0147 0.0869 0.0869
Brugia malayi Phosphoglycerate kinase 0.0177 0.1065 0.3977
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0522 0.0522
Schistosoma mansoni phosphoglycerate kinase 0.0177 0.1065 0.1065
Loa Loa (eye worm) hypothetical protein 0.0028 0.0095 0.0095
Schistosoma mansoni glutaminase 0.0284 0.1762 0.1762
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0063 0.0323 0.3032
Trypanosoma brucei Diacylglycerol kinase catalytic domain containing protein, putative 0.006 0.0309 0.158
Trypanosoma brucei diacylglycerol kinase, putative 0.006 0.0309 0.158
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.004 0.0177 0.0177
Toxoplasma gondii C-5 cytosine-specific DNA methylase superfamily protein 0.0021 0.005 0.0465
Schistosoma mansoni ap endonuclease 0.002 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0046 0.0214 0.0214
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.0522 0.0522
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0149 0.0881 0.4507
Loa Loa (eye worm) hypothetical protein 0.008 0.0438 0.0438
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0096 0.0491
Schistosoma mansoni blooms syndrome DNA helicase 0.0037 0.0158 0.0158
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0177 0.0904
Leishmania major DNA polymerase kappa, putative 0.004 0.0177 0.0904
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0147 0.0869 0.0869
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0177 0.0904
Echinococcus granulosus zinc finger protein 0.0029 0.0104 0.0104
Trypanosoma brucei phosphoglycerate kinase 0.0177 0.1065 0.5448
Echinococcus granulosus lysine specific demethylase 5A 0.0044 0.02 0.02
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0073 0.004
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0069 0.0362 0.0362
Plasmodium falciparum DNA (cytosine-5)-methyltransferase 0.0021 0.005 0.0465
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0099 0.0561 0.0561
Trypanosoma brucei DNA polymerase eta, putative 0.0067 0.0349 0.1784
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0149 0.0881 0.4507
Onchocerca volvulus 0.0484 0.3059 1
Loa Loa (eye worm) ICD-1 protein 0.0036 0.0148 0.0148
Brugia malayi Cell death protein 3 precursor 0.0028 0.0095 0.0356
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0047 0.0155
Trypanosoma cruzi metacaspase, putative 0.0028 0.0095 0.0488
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0177 0.0904
Plasmodium vivax metacaspase 1, putative 0.0028 0.0095 0.0896
Toxoplasma gondii diacylglycerol kinase catalytic domain-containing protein 0.006 0.0309 0.2898
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.003 0.011 0.011
Trypanosoma cruzi Diacylglycerol kinase catalytic domain containing protein, putative 0.006 0.0309 0.158
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0043 0.0221
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0169 0.1583
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.006 0.0309 0.158
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0013 0.0001 0.0001
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0177 0.0144
Trypanosoma brucei unspecified product 0.0028 0.0096 0.0491
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0043 0.0406
Trypanosoma brucei unspecified product 0.004 0.0177 0.0904
Mycobacterium ulcerans diacylglycerol kinase 0.006 0.0309 0.0276
Echinococcus multilocularis dnaJ subfamily B 0.127 0.816 0.816
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0073 0.0073
Echinococcus granulosus peregrin 0.0036 0.0152 0.0152
Giardia lamblia PHD finger protein 15 0.003 0.0113 0.1061
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0017 0.0026 0.0026
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0028 0.0095 0.0895
Plasmodium falciparum diacylglycerol kinase, putative 0.006 0.0309 0.2901
Brugia malayi PHD-finger family protein 0.0035 0.014 0.0524
Brugia malayi PHD-finger family protein 0.003 0.0113 0.0422
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0047 0.0155
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0073 0.0375
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0096 0.0491
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0177 0.0904
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0024 0.0075 0.0075
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0073 0.004
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0044 0.0203 0.1038
Brugia malayi Pre-SET motif family protein 0.0425 0.2679 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0047 0.0155
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0024 0.0075 0.0075
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0047 0.0155
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0177 0.1065 0.5448
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0028 0.0095 0.0312
Trichomonas vaginalis sphingosine kinase, putative 0.006 0.0309 0.101
Brugia malayi jmjC domain containing protein 0.0044 0.02 0.0748
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0044 0.0203 0.1038
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0177 0.1065 0.999
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0177 0.1065 0.3483
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0017 0.0026 0.0026
Entamoeba histolytica transcription factor BTF3, putative 0.0036 0.0148 0.0148
Leishmania major DNA polymerase eta, putative 0.0067 0.0349 0.1784
Echinococcus multilocularis phosphoglycerate kinase 1 0.0177 0.1065 0.1065
Echinococcus multilocularis DNA methyltransferase 2, putative 0.0021 0.005 0.005
Entamoeba histolytica DNA (cytosine-5)-methyltransferase, putative 0.0021 0.005 0.005
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0099 0.0561 0.0561
Brugia malayi Bromodomain containing protein 0.0036 0.0152 0.0567
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0147 0.0869 0.0869
Schistosoma mansoni DNA helicase recq5 0.0019 0.0043 0.0043
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0039 0.0169 0.1586
Brugia malayi Bloom's syndrome protein homolog 0.0047 0.0222 0.083
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0043 0.001
Schistosoma mansoni caspase-3 (C14 family) 0.0028 0.0095 0.0095
Echinococcus multilocularis zinc finger protein 0.0029 0.0104 0.0104
Echinococcus granulosus dna polymerase kappa 0.004 0.0177 0.0177
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.008 0.0438 0.0438
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0019 0.0043 0.0043
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0048 0.0228 0.0228
Brugia malayi Disco-interacting protein 2 homolog 0.004 0.0176 0.0658
Brugia malayi Diacylglycerol kinase protein 2 0.006 0.0309 0.1154
Entamoeba histolytica hypothetical protein, conserved 0.1553 1 1
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0025 0.008 0.0408
Giardia lamblia Phosphoglycerate kinase 0.0177 0.1065 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0028 0.0095 0.0312
Plasmodium falciparum phd finger protein, putative 0.003 0.0113 0.1061
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0034 0.0006
Leishmania major mitochondrial DNA polymerase beta 0.0314 0.1955 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0047 0.0155
Echinococcus multilocularis Diacylglycerol kinase theta 0.006 0.0309 0.0309
Schistosoma mansoni jumonji/arid domain-containing protein 0.0044 0.02 0.02
Echinococcus multilocularis GPCR, family 2 0.0048 0.0228 0.0228
Trichomonas vaginalis DNA polymerase eta, putative 0.004 0.0177 0.0578
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0034 0.0315
Trypanosoma brucei Metacaspase-4 0.0028 0.0095 0.0488
Entamoeba histolytica diacylglycerol kinase, putative 0.006 0.0309 0.0309
Loa Loa (eye worm) glutaminase 2 0.0284 0.1762 0.1762
Onchocerca volvulus 0.006 0.0309 0.079
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.008 0.0438 0.0438
Brugia malayi SET domain containing protein 0.0016 0.0019 0.0072
Trypanosoma cruzi diacylglycerol kinase, putative 0.006 0.0309 0.158
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0177 0.0904
Trichomonas vaginalis DNA helicase recq, putative 0.0025 0.008 0.0261
Schistosoma mansoni DNA helicase recq1 0.0019 0.0043 0.0043
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0203 0.1038
Plasmodium falciparum basic transcription factor 3b, putative 0.0036 0.0148 0.1388
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0073 0.0375
Onchocerca volvulus Alhambra homolog 0.003 0.0113 0.0133
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0043 0.0141
Loa Loa (eye worm) glutaminase 0.0284 0.1762 0.1762
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0047 0.0155
Trypanosoma cruzi metacaspase, putative 0.0028 0.0095 0.0488
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0065 0.0338 0.1729
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0045 0.0208 0.1949
Schistosoma mansoni jumonji domain containing protein 0.0079 0.0428 0.0428
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.0031 0.0031
Loa Loa (eye worm) eye-specific diacylglycerol kinase 0.006 0.0309 0.0309
Mycobacterium tuberculosis Conserved protein 0.1553 1 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0028 0.0095 0.0312
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0177 0.0904
Loa Loa (eye worm) hypothetical protein 0.0152 0.0901 0.0901
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0031 0.0031
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0069 0.0362 0.0362
Toxoplasma gondii diacylglycerol kinase accessory domain (presumed) domain-containing protein 0.006 0.0309 0.2898
Echinococcus multilocularis caspase 8 0.0028 0.0095 0.0095
Trypanosoma brucei phosphoglycerate kinase 0.0065 0.0338 0.1729
Loa Loa (eye worm) hypothetical protein 0.0024 0.0073 0.0073
Schistosoma mansoni zinc finger protein 0.0016 0.002 0.002
Schistosoma mansoni hypothetical protein 0.0048 0.0228 0.0228
Loa Loa (eye worm) jmjC domain-containing protein 0.0063 0.0323 0.0323
Trypanosoma brucei hypothetical protein, conserved 0.006 0.0309 0.158
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.004 0.0177 0.0177
Trypanosoma cruzi transcription factor btf3, putative 0.0036 0.0148 0.0756
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0047 0.0155
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0073 0.004
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0069 0.0362 0.1351
Loa Loa (eye worm) hypothetical protein 0.1553 1 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0045 0.0208 0.1947
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0095 0.0312
Plasmodium falciparum metacaspase 1 0.0028 0.0095 0.0896
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0043 0.0016
Schistosoma mansoni hypothetical protein 0.003 0.0113 0.0113
Schistosoma mansoni hypothetical protein 0.0048 0.0228 0.0228
Echinococcus multilocularis muscleblind protein 0.0149 0.0881 0.0881
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0095 0.0312
Schistosoma mansoni ap endonuclease 0.002 0.0043 0.0043
Onchocerca volvulus Ceramide kinase 1 homolog 0.006 0.0309 0.079
Echinococcus multilocularis bloom syndrome protein 0.0047 0.0222 0.0222
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.004 0.0177 0.015
Toxoplasma gondii hypothetical protein 0.0051 0.0245 0.2298
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0047 0.0155
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0177 0.0904
Echinococcus granulosus mixed lineage leukemia protein mll 0.0024 0.0075 0.0075
Schistosoma mansoni transcription factor btf3 0.0036 0.0148 0.0148
Trypanosoma cruzi metacaspase, putative 0.0028 0.0095 0.0488
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0073 0.004
Leishmania major metacaspase, putative 0.0028 0.0095 0.0488
Leishmania major phosphoglycerate kinase B, cytosolic 0.0177 0.1065 0.5448
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0522 0.0522
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0169 0.1583
Brugia malayi CXXC zinc finger family protein 0.0124 0.0721 0.2693
Mycobacterium tuberculosis Conserved hypothetical protein 0.0165 0.099 0.0966
Echinococcus granulosus phosphoglycerate kinase 1 0.0177 0.1065 0.1065
Brugia malayi Eye-specific diacylglycerol kinase 0.006 0.0309 0.1154
Schistosoma mansoni diacylglycerol kinase theta 0.006 0.0309 0.0309
Loa Loa (eye worm) hypothetical protein 0.004 0.0175 0.0175
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0177 0.1065 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0073 0.0046
Trichomonas vaginalis conserved hypothetical protein 0.006 0.0309 0.101
Echinococcus multilocularis Diacylglycerol kinase zeta 0.006 0.0309 0.0309
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0113 0.0113
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0054 0.0266 0.1359
Loa Loa (eye worm) hypothetical protein 0.0018 0.0034 0.0034
Brugia malayi beta-NAC-like protein 0.0036 0.0148 0.0552
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0113 0.0113
Trypanosoma cruzi ISWI complex protein 0.0016 0.002 0.01
Trypanosoma brucei metacaspase MCA3 0.0028 0.0095 0.0488
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0047 0.0155
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0047 0.0155
Mycobacterium tuberculosis Diacylglycerol kinase 0.006 0.0309 0.0283
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0073 0.0046
Echinococcus granulosus caspase 8 0.0028 0.0095 0.0095
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0112 0.0641 0.0641
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.003 0.011 0.011
Chlamydia trachomatis phosphoglycerate kinase 0.0177 0.1065 1
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0019 0.0043 0.0043
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0047 0.0155
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0148 0.0483
Echinococcus multilocularis transcription factor Dp 1 0.004 0.0174 0.0174
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0043 0.0159
Trichomonas vaginalis diacylglycerol kinase, putative 0.006 0.0309 0.101
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0015 0.0014 0.0014
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0073 0.0274
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0522 0.0522
Schistosoma mansoni hypothetical protein 0.0048 0.0228 0.0228
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0088 0.0488 0.4576
Trichomonas vaginalis set domain proteins, putative 0.0484 0.3059 1
Echinococcus granulosus fetal alzheimer antigen falz 0.0029 0.0101 0.0101
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0113 0.106
Echinococcus multilocularis jumonji domain containing protein 0.0042 0.019 0.019
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0177 0.1065 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.0045 0.0208 0.0208
Echinococcus multilocularis cpg binding protein 0.0131 0.0767 0.0767
Loa Loa (eye worm) hypothetical protein 0.0048 0.0228 0.0228
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0056 0.0056
Echinococcus multilocularis lysine specific demethylase 5A 0.0037 0.0154 0.0154
Trichomonas vaginalis helicase, putative 0.002 0.0047 0.0155
Schistosoma mansoni hypothetical protein 0.006 0.0309 0.0309
Loa Loa (eye worm) hypothetical protein 0.0019 0.0043 0.0043
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0028 0.0095 0.0895
Schistosoma mansoni hypothetical protein 0.0104 0.059 0.059
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0047 0.0155
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0025 0.008 0.0408
Schistosoma mansoni jumonji/arid domain-containing protein 0.0044 0.02 0.02
Brugia malayi Latrophilin receptor protein 2 0.0048 0.0228 0.0851
Trypanosoma cruzi Sphingosine kinase 0.006 0.0309 0.158
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0069 0.0362 0.0362
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0093 0.0522 0.1948
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0177 0.1065 0.1041
Toxoplasma gondii histone lysine methyltransferase SET1 0.0177 0.1066 1
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0019 0.0043 0.0043
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0093 0.0522 0.0522
Entamoeba histolytica phosphoglycerate kinase, putative 0.0177 0.1065 0.1065
Leishmania major diacylglycerol kinase-like protein 0.006 0.0309 0.158
Onchocerca volvulus 0.0063 0.0323 0.0838
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0028 0.0095 0.0356
Schistosoma mansoni transcription factor LCR-F1 0.0112 0.0641 0.0641
Toxoplasma gondii hypothetical protein 0.0088 0.0488 0.4572
Onchocerca volvulus 0.004 0.0176 0.0345
Mycobacterium ulcerans hypothetical protein 0.0165 0.099 0.096
Schistosoma mansoni DNA polymerase eta 0.0067 0.0349 0.0349
Mycobacterium ulcerans hypothetical protein 0.1553 1 1
Loa Loa (eye worm) diacylglycerol kinase 2 0.006 0.0309 0.0309
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0063 0.0323 0.0323
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0028 0.0095 0.0895
Trypanosoma cruzi ISWI complex protein 0.0016 0.002 0.01
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0095 0.0312
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0177 0.0904
Trypanosoma brucei metacaspase 0.0028 0.0095 0.0488
Mycobacterium ulcerans hypothetical protein 0.0024 0.0073 0.004
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0031 0.0031
Echinococcus multilocularis transcription factor btf3 0.0036 0.0148 0.0148
Schistosoma mansoni hypothetical protein 0.0112 0.0641 0.0641
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0034 0.0139 0.0139
Mycobacterium ulcerans phosphoglycerate kinase 0.0177 0.1065 0.1035
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0095 0.0312
Entamoeba histolytica deoxycytidyl transferase, putative 0.004 0.0177 0.0177
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0028 0.0095 0.0095
Loa Loa (eye worm) hypothetical protein 0.0149 0.0881 0.0881
Loa Loa (eye worm) hypothetical protein 0.0018 0.0034 0.0034
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0148 0.0483
Loa Loa (eye worm) hypothetical protein 0.0104 0.059 0.059
Brugia malayi hypothetical protein 0.006 0.0309 0.1154
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.004 0.0177 0.0578
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0028 0.0095 0.0312
Toxoplasma gondii exonuclease III APE 0.002 0.0043 0.0405
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0073 0.0375
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0028 0.0095 0.0312
Trypanosoma cruzi DNA polymerase eta, putative 0.0067 0.0349 0.1784
Loa Loa (eye worm) histone methyltransferase 0.003 0.011 0.011
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0095 0.0896
Loa Loa (eye worm) hypothetical protein 0.006 0.0309 0.0309
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0043 0.0161
Brugia malayi Calcitonin receptor-like protein seb-1 0.0152 0.0901 0.3364
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0065 0.0338 0.1729
Echinococcus multilocularis caspase 0.0028 0.0095 0.0095
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0323 0.0323
Schistosoma mansoni disco-interacting protein 2 (dip2) 0.0041 0.0183 0.0183
Schistosoma mansoni sphingoid long chain base kinase 0.1553 1 1
Echinococcus multilocularis dna polymerase kappa 0.004 0.0177 0.0177
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0028 0.0095 0.0312
Trypanosoma cruzi transcription factor btf3, putative 0.0036 0.0148 0.0756
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0048 0.0228 0.0228
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.004 0.0177 0.0177
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0177 0.0904
Schistosoma mansoni hypothetical protein 0.0021 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.004 0.0176 0.0176
Echinococcus multilocularis ceramide kinase 0.006 0.0309 0.0309
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0159 0.0159
Trypanosoma cruzi metacaspase 5, putative 0.0028 0.0095 0.0488
Echinococcus granulosus GPCR family 2 0.0048 0.0228 0.0228
Schistosoma mansoni caspase-7 (C14 family) 0.0028 0.0095 0.0095
Leishmania major diacylglycerol kinase, putative 0.006 0.0309 0.158
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.0522 0.0522
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0073 0.004
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0095 0.0312
Loa Loa (eye worm) bromodomain containing protein 0.0022 0.0058 0.0058
Trypanosoma brucei phosphoglycerate kinase, putative 0.0065 0.0338 0.1729
Echinococcus granulosus transcription factor Dp 1 0.004 0.0174 0.0174
Schistosoma mansoni hypothetical protein 0.0016 0.002 0.002
Entamoeba histolytica hypothetical protein 0.0036 0.0148 0.0148
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0073 0.004
Trichomonas vaginalis bmru protein, putative 0.006 0.0309 0.101
Loa Loa (eye worm) hypothetical protein 0.0149 0.0881 0.0881
Schistosoma mansoni cpg binding protein 0.0131 0.0767 0.0767
Echinococcus granulosus acylglycerol kinase mitochondrial 0.006 0.0309 0.0309
Trichomonas vaginalis sphingosine kinase, putative 0.006 0.0309 0.101
Brugia malayi jmjC domain containing protein 0.0099 0.0561 0.2094
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0177 0.0904
Leishmania major DNA polymerase eta, putative 0.0039 0.0169 0.0865
Echinococcus granulosus dnaJ subfamily B 0.127 0.816 0.816
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0043 0.0406
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0063 0.0323 0.0323
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0362 0.1851
Echinococcus multilocularis peregrin 0.0036 0.0152 0.0152
Loa Loa (eye worm) hypothetical protein 0.0074 0.0394 0.0394
Entamoeba histolytica diacylglycerol kinase, putative 0.006 0.0309 0.0309
Mycobacterium tuberculosis Conserved hypothetical protein 0.004 0.0177 0.015
Trypanosoma brucei metacaspase 5, putative 0.0028 0.0095 0.0488
Brugia malayi Ceramide kinase 0.006 0.0309 0.1154
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0113 0.0113
Plasmodium falciparum diacylglycerol kinase, putative 0.006 0.0309 0.2901
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0314 0.1955 1
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0095 0.0312
Leishmania major basic transcription factor 3a, putative 0.0036 0.0148 0.0756
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0028 0.0095 0.0312
Entamoeba histolytica hypothetical protein 0.0112 0.0641 0.0641
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0029 0.0101 0.0101
Loa Loa (eye worm) hypothetical protein 0.006 0.0309 0.0309
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0043 0.0406
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0177 0.0904
Entamoeba histolytica hypothetical protein 0.0112 0.0641 0.0641
Echinococcus multilocularis dna polymerase eta 0.0067 0.0349 0.0349
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0425 0.2679 0.2679
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0043 0.0043
Schistosoma mansoni diacylglycerol kinase zeta iota 0.006 0.0309 0.0309
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0177 0.0904
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0113 0.0113
Echinococcus granulosus Diacylglycerol kinase theta 0.006 0.0309 0.0309
Plasmodium vivax DNA (cytosine-5)-methyltransferase, putative 0.0021 0.005 0.0465
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0028 0.0095 0.0312
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.006 0.0309 0.158
Schistosoma mansoni bromodomain containing protein 0.0013 0.0001 0.0001
Mycobacterium ulcerans glutaminase 0.0284 0.1762 0.1734
Echinococcus granulosus jumonji domain containing protein 0.0042 0.019 0.019
Echinococcus granulosus caspase 2 0.0028 0.0095 0.0095
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0043 0.0399
Schistosoma mansoni hypothetical protein 0.0176 0.106 0.106
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0032 0.0121 0.1133
Trypanosoma cruzi Sphingosine kinase 0.006 0.0309 0.158
Plasmodium falciparum metacaspase-like protein 0.0028 0.0095 0.0896
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0073 0.0274
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0362 0.1851
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0069 0.0362 0.0362
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0047 0.0155
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0191 0.1159 0.1159
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0043 0.0221
Echinococcus granulosus muscleblind protein 0.0149 0.0881 0.0881
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0065 0.0338 0.1729
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0071 0.0375 0.0375
Schistosoma mansoni hypothetical protein 0.0176 0.106 0.106
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0043 0.0399
Plasmodium vivax phosphoglycerate kinase, putative 0.0177 0.1065 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0124 0.0721 0.0721
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0112 0.0641 0.0641
Leishmania major sphingosine kinase A, B, putative 0.006 0.0309 0.158
Plasmodium vivax hypothetical protein, conserved 0.0015 0.0016 0.0149
Brugia malayi Bromodomain containing protein 0.0043 0.0198 0.0738
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0059 0.0296 0.0296
Brugia malayi Phosphoglycerate kinase 0.0065 0.0338 0.1262
Trichomonas vaginalis diacylglycerol kinase, putative 0.006 0.0309 0.101
Schistosoma mansoni terminal deoxycytidyl transferase 0.004 0.0177 0.0177
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0065 0.0338 0.1729
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0019 0.0043 0.04
Brugia malayi glutaminase DH11.1 0.0284 0.1762 0.6577
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0113 0.106
Giardia lamblia DINP protein human, muc B family 0.004 0.0177 0.166
Entamoeba histolytica recQ family helicase, putative 0.0025 0.008 0.008
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0177 0.1065 0.999
Trichomonas vaginalis DNA helicase recq1, putative 0.0047 0.0222 0.0727
Loa Loa (eye worm) ceramide kinase 0.006 0.0309 0.0309
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0015 0.0016 0.0149
Loa Loa (eye worm) hypothetical protein 0.0143 0.0847 0.0847
Echinococcus granulosus dna polymerase eta 0.0067 0.0349 0.0349
Loa Loa (eye worm) hypothetical protein 0.006 0.0309 0.0309
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0362 0.1851
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0148 0.0483
Schistosoma mansoni cpg binding protein 0.0131 0.0767 0.0767
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.006 0.0309 0.101
Brugia malayi F/Y-rich N-terminus family protein 0.0041 0.0185 0.069
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0177 0.1065 0.5448
Toxoplasma gondii DNA methyltransferase 2, putative 0.0021 0.005 0.0465
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0047 0.0155
Plasmodium vivax diacylglycerol kinase, putative 0.006 0.0309 0.2901
Schistosoma mansoni phosphoglycerate kinase 0.0177 0.1065 0.1065
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0043 0.0221
Echinococcus multilocularis disco interacting protein 2 0.0041 0.0183 0.0183
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0152 0.0901 0.3364
Echinococcus granulosus bloom syndrome protein 0.0047 0.0222 0.0222
Echinococcus granulosus geminin 0.0176 0.106 0.106
Schistosoma mansoni DNA (cytosine-5)-methyltransferase 0.0021 0.005 0.005
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0041 0.0185 0.1738
Echinococcus multilocularis sphingosine kinase 1 0.1553 1 1
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0032 0.0123 0.1157
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0096 0.0491
Trypanosoma cruzi metacaspase 5, putative 0.0028 0.0095 0.0488
Echinococcus granulosus histone lysine methyltransferase setb 0.008 0.0438 0.0438
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0073 0.004
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0028 0.0095 0.0095
Plasmodium vivax basic transcription factor 3b, putative 0.0036 0.0148 0.1388
Schistosoma mansoni caspase-7 (C14 family) 0.0028 0.0095 0.0095
Entamoeba histolytica hypothetical protein 0.0112 0.0641 0.0641
Loa Loa (eye worm) hypothetical protein 0.003 0.0113 0.0113
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0177 0.0904
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.0031 0.0031
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0045 0.0208 0.1947
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0034 0.0315
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.006 0.0309 0.0309
Trypanosoma brucei cytosine-specific DNA methylase, putative 0.0021 0.005 0.0254
Brugia malayi PHD-finger family protein 0.0017 0.0026 0.0099
Loa Loa (eye worm) hypothetical protein 0.0024 0.0073 0.0073
Echinococcus granulosus cpg binding protein 0.0131 0.0767 0.0767
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0071 0.0375 0.0375
Trichomonas vaginalis DNA helicase recq, putative 0.0047 0.0222 0.0727
Schistosoma mansoni bromodomain containing protein 0.0074 0.0399 0.0399
Trypanosoma cruzi hypothetical protein, conserved 0.006 0.0309 0.158
Brugia malayi hypothetical protein 0.0112 0.0641 0.2394
Brugia malayi ImpB/MucB/SamB family protein 0.0067 0.0349 0.1302
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0159 0.0159
Toxoplasma gondii NAC domain-containing protein 0.0036 0.0148 0.1386
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0177 0.0904
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0043 0.0043
Entamoeba histolytica diacylglycerol kinase, putative 0.006 0.0309 0.0309
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.004 0.0177 0.0177
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0025 0.008 0.0408
Trichomonas vaginalis glutaminase, putative 0.0284 0.1762 0.576
Schistosoma mansoni diacylglycerol kinase theta 0.006 0.0309 0.0309
Loa Loa (eye worm) hypothetical protein 0.0018 0.0034 0.0034
Entamoeba histolytica hypothetical protein 0.0112 0.0641 0.0641
Brugia malayi Muscleblind-like protein 0.0149 0.0881 0.329
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.004 0.0177 0.0904
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0177 0.0904
Leishmania major hypothetical protein, conserved 0.0016 0.002 0.01
Brugia malayi acetyltransferase, GNAT family protein 0.0147 0.0869 0.3243
Giardia lamblia Sgs1 DNA helicase, putative 0.0019 0.0043 0.04
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.0522 0.0522
Trichomonas vaginalis bmru protein, putative 0.006 0.0309 0.101
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0073 0.0274
Schistosoma mansoni hypothetical protein 0.127 0.816 0.816
Loa Loa (eye worm) hypothetical protein 0.0024 0.0073 0.0073
Trypanosoma brucei Sphingosine kinase 0.006 0.0309 0.158
Leishmania major phosphoglycerate kinase C, glycosomal 0.0177 0.1065 0.5448
Loa Loa (eye worm) hypothetical protein 0.0177 0.1065 0.1065
Leishmania major hypothetical protein, conserved 0.006 0.0309 0.158
Brugia malayi diacylglycerol kinase 0.006 0.0309 0.1154
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0203 0.1038
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0177 0.1065 0.3483
Loa Loa (eye worm) hypothetical protein 0.0018 0.0034 0.0034
Echinococcus granulosus Diacylglycerol kinase zeta 0.006 0.0309 0.0309
Trypanosoma brucei unspecified product 0.0028 0.0096 0.0491
Brugia malayi Pre-SET motif family protein 0.0063 0.0323 0.1207
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0065 0.0338 0.1729
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0047 0.0155
Leishmania major modification methylase-like protein 0.0021 0.005 0.0254
Plasmodium vivax diacylglycerol kinase, putative 0.006 0.0309 0.2901
Trypanosoma brucei phosphoglycerate kinase 0.0177 0.1065 0.5448
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0073 0.0073
Trichomonas vaginalis bromodomain-containing protein, putative 0.0045 0.0208 0.0679
Brugia malayi ImpB/MucB/SamB family protein 0.004 0.0177 0.066
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0043 0.0141
Trypanosoma cruzi diacylglycerol kinase, putative 0.006 0.0309 0.158
Loa Loa (eye worm) jmjC domain-containing protein 0.0044 0.02 0.02
Toxoplasma gondii diacylglycerol kinase, putative 0.006 0.0309 0.2898
Trypanosoma brucei metacaspase MCA2 0.0028 0.0095 0.0488
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0048 0.0228 0.0851
Echinococcus multilocularis caspase 2 0.0028 0.0095 0.0095
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0047 0.0155
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0149 0.0881 0.4507

Activities

Activity type Activity value Assay description Source Reference
MIC80 (functional) > 32 ug ml-1 Antifungal activity against Cryptococcus neoformans after 72 hrs by broth microdilution method ChEMBL. 24051242

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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