Detailed information for compound 1788047

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 329.349 | Formula: C21H15NO3
  • H donors: 0 H acceptors: 2 LogP: 3.98 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C(=O)c1cn(c2c1cccc2)Cc1ccccc1)c1ccco1
  • InChi: 1S/C21H15NO3/c23-20(21(24)19-11-6-12-25-19)17-14-22(13-15-7-2-1-3-8-15)18-10-5-4-9-16(17)18/h1-12,14H,13H2
  • InChiKey: DOBBIMQEYLMEOG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens adenosine A1 receptor Starlite/ChEMBL References
Homo sapiens adenosine A2a receptor Starlite/ChEMBL References
Homo sapiens adenosine A3 receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi follicle stimulating hormone receptor adenosine A2a receptor 412 aa 336 aa 22.3 %
Brugia malayi hypothetical protein adenosine A1 receptor 326 aa 305 aa 21.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0473 0.1652 0.1652
Onchocerca volvulus 0.0037 0.0079 0.0079
Echinococcus granulosus short transient receptor potential channel 6 0.0039 0.0086 0.0086
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0037 0.0079 0.0079
Brugia malayi putative neuropeptide receptor NPR1 0.0037 0.0079 0.0079
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0083 0.0244 0.0244
Trichomonas vaginalis guanylate cyclase, putative 0.0028 0.0045 0.0188
Loa Loa (eye worm) hypothetical protein 0.0037 0.0079 0.0079
Trichomonas vaginalis adenylate cyclase, putative 0.0028 0.0045 0.0188
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0037 0.0079 0.0079
Onchocerca volvulus 0.0037 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0473 0.1652 0.1652
Brugia malayi hypothetical protein 0.0037 0.0079 0.0079
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0039 0.0086 0.0086
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0037 0.0079 0.0079
Echinococcus multilocularis rhodopsin orphan GPCR 0.0037 0.0079 0.0079
Echinococcus multilocularis serotonin transporter 0.2788 1 1
Onchocerca volvulus 0.0037 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0025 0.0033 0.0033
Entamoeba histolytica hypothetical protein 0.002 0.0018 0.1149
Loa Loa (eye worm) hypothetical protein 0.0037 0.0079 0.0079
Echinococcus multilocularis neuropeptide FF receptor 2 0.0037 0.0079 0.0079
Echinococcus granulosus biogenic amine 5HT receptor 0.0037 0.0079 0.0079
Schistosoma mansoni metabotropic glutamate receptor 0.002 0.0016 0.0016
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0083 0.0244 0.1017
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0018 0.0018
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0175 0.0175
Schistosoma mansoni serine/threonine protein kinase 0.0044 0.0103 0.0103
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0037 0.0079 0.0079
Brugia malayi Cytochrome P450 family protein 0.0035 0.007 0.007
Brugia malayi N-terminal motif family protein 0.0223 0.0751 0.0751
Loa Loa (eye worm) hypothetical protein 0.0037 0.0079 0.0079
Echinococcus granulosus sex peptide receptor 0.0037 0.0079 0.0079
Echinococcus granulosus g protein coupled receptor 0.0037 0.0079 0.0079
Schistosoma mansoni voltage-gated potassium channel 0.0039 0.0086 0.0086
Plasmodium falciparum transporter, putative 0.0473 0.1652 1
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0025 0.0033 0.0033
Echinococcus granulosus rhodopsin orphan GPCR 0.0037 0.0079 0.0079
Schistosoma mansoni transient receptor potential channel 4 0.0039 0.0086 0.0086
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0044 0.0103 0.0103
Onchocerca volvulus 0.0037 0.0079 0.0079
Echinococcus granulosus biogenic amine 5HT receptor 0.0037 0.0079 0.0079
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.0195 0.0195
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0037 0.0079 0.0079
Loa Loa (eye worm) melatonin receptor type 1A 0.0037 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0037 0.0079 0.0079
Echinococcus granulosus potassium voltage gated channel protein 0.0039 0.0086 0.0086
Echinococcus multilocularis voltage dependent calcium channel 0.0039 0.0086 0.0086
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0025 0.0033 0.0033
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0064 0.0175 0.0175
Onchocerca volvulus 0.0037 0.0079 0.0079
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.006 0.006
Toxoplasma gondii transporter, cation channel family protein 0.0039 0.0086 0.052
Echinococcus granulosus rhodopsin orphan GPCR 0.0037 0.0079 0.0079
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.002 0.0018 0.0018
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0018 0.0073
Echinococcus multilocularis neuropeptide Y receptor 0.0037 0.0079 0.0079
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0025 0.0033 0.0033
Brugia malayi CXXC zinc finger family protein 0.0028 0.0047 0.0047
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0044 0.0103 0.0103
Echinococcus granulosus rhodopsin orphan GPCR 0.0037 0.0079 0.0079
Trichomonas vaginalis adenylate cyclase type vIII, putative 0.0028 0.0045 0.0188
Brugia malayi Cytochrome P450 family protein 0.0024 0.0031 0.0031
Echinococcus granulosus serotonin receptor 0.0037 0.0079 0.0079
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0025 0.0033 0.0033
Onchocerca volvulus 0.0473 0.1652 0.1652
Schistosoma mansoni hypothetical protein 0.0037 0.0079 0.0079
Onchocerca volvulus 0.0037 0.0079 0.0079
Echinococcus granulosus rhodopsin orphan GPCR 0.0037 0.0079 0.0079
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0025 0.0033 0.0033
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0045 0.0188
Trichomonas vaginalis adenylate cyclase, putative 0.0028 0.0045 0.0188
Loa Loa (eye worm) hypothetical protein 0.0037 0.0079 0.0079
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0326 0.112 0.112
Onchocerca volvulus 0.0037 0.0079 0.0079
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0039 0.0086 0.0086
Schistosoma mansoni nAChR subunit 0.0025 0.0033 0.0033
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0044 0.0103 0.0626
Onchocerca volvulus 0.0037 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0025 0.0033 0.0033
Echinococcus multilocularis potassium voltage gated channel protein 0.0039 0.0086 0.0086
Schistosoma mansoni adenoreceptor 0.0037 0.0079 0.0079
Schistosoma mansoni hypothetical protein 0.0069 0.0195 0.0195
Loa Loa (eye worm) hypothetical protein 0.0025 0.0033 0.0033
Onchocerca volvulus 0.0025 0.0033 0.0033
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0037 0.0079 0.0079
Mycobacterium ulcerans short chain dehydrogenase 0.0561 0.1969 1
Trichomonas vaginalis adenylate cyclase type, putative 0.0028 0.0045 0.0188
Echinococcus granulosus metabotropic glutamate receptor 5 0.005 0.0125 0.0125
Echinococcus granulosus neuropeptide Y receptor 0.0037 0.0079 0.0079
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0473 0.1652 0.1652
Brugia malayi hypothetical protein 0.0037 0.0079 0.0079
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.0044 0.0103 0.0103
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0083 0.0244 0.0244
Schistosoma mansoni serine/threonine protein kinase 0.0044 0.0103 0.0103
Trichomonas vaginalis guanylate cyclase, putative 0.0028 0.0045 0.0188
Schistosoma mansoni histamine h1 receptor 0.0037 0.0079 0.0079
Brugia malayi PXA domain containing protein 0.002 0.0018 0.0018
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.0044 0.0103 0.0103
Echinococcus granulosus voltage gated potassium channel 0.0039 0.0086 0.0086
Schistosoma mansoni hypothetical protein 0.0032 0.006 0.006
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0473 0.1652 0.1652
Loa Loa (eye worm) hypothetical protein 0.0025 0.0033 0.0033
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0039 0.0086 0.064
Loa Loa (eye worm) hypothetical protein 0.0037 0.0079 0.0079
Loa Loa (eye worm) glutamate receptor 0.0016 0.0002 0.0002
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0039 0.0086 0.0086
Brugia malayi ORL1-like opioid receptor 0.0037 0.0079 0.0079
Echinococcus granulosus neuropeptide receptor 0.0037 0.0079 0.0079
Trichomonas vaginalis adenylate cyclase, putative 0.0028 0.0045 0.0188
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0058 0.0153 0.0925
Plasmodium falciparum amino acid transporter, putative 0.0473 0.1652 1
Loa Loa (eye worm) hypothetical protein 0.0083 0.0243 0.0243
Brugia malayi cation channel family protein 0.0039 0.0086 0.0086
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0387 0.1341 0.1341
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0473 0.1652 0.1652
Echinococcus granulosus glycine receptor subunit beta 0.0025 0.0033 0.0033
Onchocerca volvulus 0.0037 0.0079 0.0079
Brugia malayi Serotonin receptor 0.0037 0.0079 0.0079
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0047 0.0047
Trichomonas vaginalis adenylate cyclase type IX, putative 0.0028 0.0045 0.0188
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0028 0.0045 0.0188
Loa Loa (eye worm) hypothetical protein 0.0039 0.0086 0.0086
Echinococcus multilocularis patatin phospholipase domain containing protein 0.0044 0.0103 0.0103
Echinococcus granulosus g-protein coupled receptor 0.0037 0.0079 0.0079
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0044 0.0103 0.0103
Trichomonas vaginalis guanylate cyclase, putative 0.0028 0.0045 0.0188
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0037 0.0278
Loa Loa (eye worm) hypothetical protein 0.0037 0.0079 0.0079
Mycobacterium ulcerans hypothetical protein 0.0044 0.0103 0.0525
Loa Loa (eye worm) cytochrome P450 family protein 0.0035 0.007 0.007
Schistosoma mansoni biogenic amine (5HT) receptor 0.0037 0.0079 0.0079
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.0039 0.0086 0.0086
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0028 0.0045 0.0188
Trichomonas vaginalis adenylate cyclase type IX, putative 0.0028 0.0045 0.0188
Echinococcus multilocularis fmrfamide receptor 0.0037 0.0079 0.0079
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0028 0.0045 0.0188
Schistosoma mansoni calcium-activated potassium channel 0.0039 0.0086 0.0086
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0028 0.0045 0.0188
Brugia malayi Pre-SET motif family protein 0.0064 0.0175 0.0175
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0025 0.0033 0.0033
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.0039 0.0086 0.0086
Trichomonas vaginalis guanylate cyclase, putative 0.0028 0.0045 0.0188
Loa Loa (eye worm) hypothetical protein 0.0025 0.0033 0.0033
Trichomonas vaginalis guanylate cyclase, putative 0.0028 0.0045 0.0188
Brugia malayi G protein-coupled receptor F59B2.13 0.0037 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0025 0.0033 0.0033
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0039 0.0086 0.0086
Schistosoma mansoni opsin-like receptor 0.0037 0.0079 0.0079
Trichomonas vaginalis adenylate cyclase, putative 0.0028 0.0045 0.0188
Loa Loa (eye worm) hypothetical protein 0.0473 0.1652 0.1652
Brugia malayi A-kinase anchor protein 10, precursor 0.002 0.0018 0.0018
Onchocerca volvulus 0.0037 0.0079 0.0079
Echinococcus granulosus sodium and chloride dependent glycine 0.0473 0.1652 0.1652
Schistosoma mansoni nAChR subunit 0.0025 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0025 0.0033 0.0033
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0025 0.0033 0.0033
Echinococcus multilocularis transient receptor potential cation channel 0.0039 0.0086 0.0086
Echinococcus granulosus tm gpcr rhodopsin 0.0037 0.0079 0.0079
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0083 0.0244 0.0244
Schistosoma mansoni hypothetical protein 0.0037 0.0079 0.0079
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0083 0.0244 0.0244
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0223 0.0751 0.0751
Loa Loa (eye worm) hypothetical protein 0.0037 0.0079 0.0079
Loa Loa (eye worm) voltage-gated potassium channel 0.0039 0.0086 0.0086
Echinococcus granulosus potassium voltage gated channel protein 0.0039 0.0086 0.0086
Echinococcus granulosus cAMP dependent protein kinase regulatory 0.0044 0.0103 0.0103
Brugia malayi G protein-coupled receptor 0.0037 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0039 0.0086 0.0086
Brugia malayi regulator of G-protein signaling egl-10 0.0029 0.005 0.005
Onchocerca volvulus 0.0025 0.0033 0.0033
Mycobacterium tuberculosis Probable transcriptional regulatory protein Cmr 0.0044 0.0103 0.0525
Brugia malayi hypothetical protein 0.0473 0.1652 0.1652
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0039 0.0086 0.064
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.0039 0.0086 0.0086
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0025 0.0033 0.0033
Echinococcus granulosus transient receptor potential cation channel 0.0039 0.0086 0.0086
Echinococcus granulosus two pore calcium channel protein 2 0.0039 0.0086 0.0086
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0025 0.0033 0.0033
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0473 0.1652 1
Brugia malayi Transient-receptor-potential like protein 0.0039 0.0086 0.0086
Echinococcus multilocularis expressed protein 0.0392 0.136 0.136
Echinococcus multilocularis hyperpolarization activated cyclic 0.0083 0.0244 0.0244
Echinococcus granulosus short transient receptor potential channel 6 0.0039 0.0086 0.0086
Trichomonas vaginalis guanylate cyclase, putative 0.0028 0.0045 0.0188
Echinococcus multilocularis calcium activated potassium channel 0.0039 0.0086 0.0086
Brugia malayi metabotropic glutamate receptor type 2 0.002 0.0016 0.0016
Schistosoma mansoni camp-dependent protein kinase type II regulatory subunit 0.0044 0.0103 0.0103
Onchocerca volvulus 0.0094 0.0284 0.0284
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0045 0.0188
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0473 0.1652 0.1652
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0473 0.1652 1
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0039 0.0086 0.0086
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0045 0.0188
Onchocerca volvulus 0.0044 0.0103 0.0103
Echinococcus granulosus cGMP dependent protein kinase 1 0.0044 0.0103 0.0103
Echinococcus granulosus potassium voltage gated channel protein 0.0039 0.0086 0.0086
Loa Loa (eye worm) hypothetical protein 0.0037 0.0079 0.0079
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0326 0.112 0.112
Onchocerca volvulus 0.0037 0.0079 0.0079
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0028 0.0045 0.0188
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0326 0.112 0.112
Loa Loa (eye worm) cytochrome P450 family protein 0.0024 0.0031 0.0031
Brugia malayi RE15519p 0.0037 0.0079 0.0079
Trypanosoma cruzi cAMP binding protein, putative 0.0044 0.0103 0.0771
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0037 0.0079 0.0079
Trichomonas vaginalis guanylate cyclase, putative 0.0028 0.0045 0.0188
Loa Loa (eye worm) hypothetical protein 0.072 0.2542 0.2542
Brugia malayi Calcitonin receptor-like protein seb-1 0.0101 0.031 0.031
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0111 0.0345 0.0345
Loa Loa (eye worm) hypothetical protein 0.002 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0039 0.0086 0.0086
Loa Loa (eye worm) hypothetical protein 0.0037 0.0079 0.0079
Schistosoma mansoni voltage-gated cation channel 0.0039 0.0086 0.0086
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0039 0.0086 0.0086
Schistosoma mansoni camp-dependent protein kinase regulatory chain 0.0044 0.0103 0.0103
Echinococcus multilocularis fmrfamide receptor 0.0037 0.0079 0.0079
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0044 0.0103 0.0626
Echinococcus multilocularis voltage gated hydrogen channel 1 0.0039 0.0086 0.0086
Brugia malayi hypothetical protein 0.0037 0.0079 0.0079
Schistosoma mansoni voltage-gated potassium channel 0.0039 0.0086 0.0086
Echinococcus granulosus glycine receptor subunit alpha 1 0.0025 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0473 0.1652 0.1652
Echinococcus multilocularis glycine receptor subunit beta 0.0025 0.0033 0.0033
Echinococcus multilocularis voltage gated potassium channel 0.0111 0.0345 0.0345
Loa Loa (eye worm) hypothetical protein 0.0037 0.0079 0.0079
Brugia malayi Egg laying defective protein 4 0.0044 0.0103 0.0103
Brugia malayi voltage-dependent calcium channel 0.0039 0.0086 0.0086
Echinococcus granulosus tumor protein p63 0.0353 0.1219 0.1219
Loa Loa (eye worm) hypothetical protein 0.0037 0.0079 0.0079
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0018 0.0018
Echinococcus granulosus g protein coupled receptor 0.0037 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0039 0.0086 0.0086
Loa Loa (eye worm) hypothetical protein 0.0037 0.0079 0.0079
Echinococcus multilocularis neuropeptide receptor 0.0037 0.0079 0.0079
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.2788 1 1
Echinococcus multilocularis glycine receptor subunit beta 0.0025 0.0033 0.0033
Mycobacterium tuberculosis Conserved protein 0.0044 0.0103 0.0525
Schistosoma mansoni biogenic amine receptor 0.0037 0.0079 0.0079
Echinococcus multilocularis sodium leak channel non selective protein 0.0039 0.0086 0.0086
Echinococcus granulosus cGMP dependent protein kinase 0.0044 0.0103 0.0103
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0037 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0039 0.0086 0.0086
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0037 0.0079 0.0079
Schistosoma mansoni alpha-1 adrenergic receptor 0.0037 0.0079 0.0079
Onchocerca volvulus 0.0037 0.0079 0.0079
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0083 0.0244 0.1017
Schistosoma mansoni biogenic amine receptor 0.0037 0.0079 0.0079
Trypanosoma brucei cAMP binding protein, putative 0.0044 0.0103 0.0771
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0025 0.0033 0.0033
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0044 0.0103 0.043
Trichomonas vaginalis ap endonuclease, putative 0.0058 0.0153 0.0636
Echinococcus granulosus rhodopsin orphan GPCR 0.0037 0.0079 0.0079
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0028 0.0045 0.0188
Trichomonas vaginalis adenylate cyclase type III, putative 0.0028 0.0045 0.0188
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0025 0.0033 0.0033
Echinococcus granulosus voltage gated hydrogen channel 1 0.0039 0.0086 0.0086
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.072 0.2542 0.2542
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0034 0.0067 0.0067
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0045 0.0188
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0175 0.0175
Schistosoma mansoni regulator of G protein signaling 0.002 0.0018 0.0018
Trypanosoma brucei cAMP response protein 1, putative 0.0044 0.0103 0.0771
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0025 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0094 0.0284 0.0284
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.0044 0.0103 0.0525
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.0044 0.0103 0.0103
Brugia malayi olfactory channel protein osm-9 0.0039 0.0086 0.0086
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0025 0.0033 0.0033
Schistosoma mansoni transient receptor potential channel 0.0039 0.0086 0.0086
Loa Loa (eye worm) neuropeptide F receptor 0.0037 0.0079 0.0079
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0064 0.0175 0.0175
Brugia malayi Cytochrome P450 family protein 0.0024 0.0031 0.0031
Mycobacterium tuberculosis Probable oxidoreductase 0.0561 0.1969 1
Echinococcus multilocularis transient receptor potential cation channel 0.0039 0.0086 0.0086
Plasmodium vivax CAMP-dependent protein kinase regulatory subunit, putative 0.0044 0.0103 0.0626
Echinococcus granulosus transient receptor potential gamma protein 0.0039 0.0086 0.0086
Schistosoma mansoni voltage-gated potassium channel 0.0039 0.0086 0.0086
Echinococcus granulosus 7TM GPCR rhodopsin 0.0037 0.0079 0.0079
Schistosoma mansoni hypothetical protein 0.0044 0.0103 0.0103
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0018 0.0018
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0025 0.0033 0.0033
Trichomonas vaginalis guanylate cyclase, putative 0.0028 0.0045 0.0188
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0111 0.0345 0.0345
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0039 0.0086 0.0086
Loa Loa (eye worm) hypothetical protein 0.0037 0.0079 0.0079
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0083 0.0244 0.0244
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0018 0.0073
Schistosoma mansoni ap endonuclease 0.0058 0.0153 0.0153
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0039 0.0086 0.0086
Mycobacterium ulcerans hypothetical protein 0.0044 0.0103 0.0525
Loa Loa (eye worm) hypothetical protein 0.0025 0.0033 0.0033
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0037 0.0226
Echinococcus granulosus patatin phospholipase domain containing protein 0.0044 0.0103 0.0103
Brugia malayi Serotonin receptor 0.0037 0.0079 0.0079
Echinococcus multilocularis neuropeptide Y receptor 0.0037 0.0079 0.0079
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.017 0.017
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0147 0.0889
Trypanosoma brucei Flagellar Member 6 0.0044 0.0103 0.0771
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.002 0.0018 0.0018
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0044 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.0387 0.1341 0.1341
Echinococcus granulosus tm gpcr rhodopsin 0.0037 0.0079 0.0079
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0025 0.0033 0.0033
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0039 0.0086 0.0086
Loa Loa (eye worm) hypothetical protein 0.0198 0.0658 0.0658
Schistosoma mansoni axis inhibition protein axin 0.002 0.0018 0.0018
Schistosoma mansoni sodium-dependent amino acid transporter 0.0473 0.1652 0.1652
Leishmania major hypothetical protein, conserved 0.0044 0.0103 0.0771
Echinococcus multilocularis regulator of G protein signaling 0.002 0.0018 0.0018
Echinococcus multilocularis rhodopsin orphan GPCR 0.0037 0.0079 0.0079
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0037 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0037 0.0079 0.0079
Schistosoma mansoni two-pore calcium channel 0.0039 0.0086 0.0086
Echinococcus granulosus glycine receptor subunit beta 0.0025 0.0033 0.0033
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0025 0.0033 0.0033
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.006 0.006
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0473 0.1652 0.1652
Trichomonas vaginalis adenylate cyclase type VI, putative 0.0028 0.0045 0.0188
Loa Loa (eye worm) hypothetical protein 0.0039 0.0086 0.0086
Loa Loa (eye worm) glutamate receptor 0.0041 0.0091 0.0091
Echinococcus multilocularis potassium voltage gated channel protein 0.0039 0.0086 0.0086
Trichomonas vaginalis set domain proteins, putative 0.0501 0.1752 0.7297
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0028 0.0045 0.0188
Loa Loa (eye worm) hypothetical protein 0.0037 0.0079 0.0079
Giardia lamblia CAMP-dependent protein kinase regulatory chain 0.0044 0.0103 0.6763
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0018 0.0018
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.0039 0.0086 0.0086
Loa Loa (eye worm) hypothetical protein 0.0037 0.0079 0.0079
Echinococcus granulosus sodium channel protein 0.0039 0.0086 0.0086
Brugia malayi hypothetical protein 0.0039 0.0086 0.0086
Loa Loa (eye worm) hypothetical protein 0.2788 1 1
Echinococcus granulosus neuropeptides capa receptor 0.0037 0.0079 0.0079
Loa Loa (eye worm) cytochrome P450 family protein 0.0024 0.0031 0.0031
Brugia malayi cation channel family protein 0.0039 0.0086 0.0086
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0018 0.0018
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0025 0.0033 0.0033
Schistosoma mansoni ryanodine receptor related 0.0039 0.0086 0.0086
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.006 0.006
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0039 0.0086 0.0086
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0044 0.0103 0.0103
Schistosoma mansoni amine GPCR 0.0037 0.0079 0.0079
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0037 0.0079 0.0079
Trypanosoma cruzi regulatory subunit of protein kinase a-like protein, putative 0.0044 0.0103 0.0771
Trichomonas vaginalis adenylate cyclase type IX, putative 0.0028 0.0045 0.0188
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0473 0.1652 0.1652
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0039 0.0086 0.0086
Brugia malayi putative neuropeptide receptor 0.0037 0.0079 0.0079
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0037 0.0079 0.0079
Mycobacterium ulcerans transmembrane transport protein 0.0044 0.0103 0.0525
Loa Loa (eye worm) ACC-1 protein 0.0025 0.0033 0.0033
Loa Loa (eye worm) G-protein coupled receptor 0.0037 0.0079 0.0079
Echinococcus granulosus cpg binding protein 0.003 0.0053 0.0053
Loa Loa (eye worm) cAMP-dependent protein kinase regulatory subunit 0.0044 0.0103 0.0103
Schistosoma mansoni voltage-gated potassium channel 0.0354 0.1221 0.1221
Leishmania major hypothetical protein, unknown function 0.0044 0.0103 0.0771
Schistosoma mansoni voltage-gated potassium channel 0.0083 0.0244 0.0244
Mycobacterium leprae Possible transporter protein 0.0028 0.0045 0.4373
Echinococcus multilocularis rhodopsin orphan GPCR 0.0037 0.0079 0.0079
Echinococcus multilocularis potassium voltage gated channel protein 0.0039 0.0086 0.0086
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0039 0.0086 0.0086
Echinococcus granulosus 7tm_1 domain containing protein 0.0037 0.0079 0.0079
Echinococcus granulosus beta-adrenergic receptor kinase 0.002 0.0018 0.0018
Echinococcus granulosus hyperpolarization activated cyclic 0.0083 0.0244 0.0244
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0025 0.0033 0.0033
Trichomonas vaginalis guanylate cyclase, putative 0.0028 0.0045 0.0188
Onchocerca volvulus 0.0501 0.1752 0.1752
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0025 0.0033 0.0033
Brugia malayi Dopamine receptor 0.0037 0.0079 0.0079
Loa Loa (eye worm) TYRA-2 protein 0.0037 0.0079 0.0079
Brugia malayi sulfakinin receptor protein 0.0037 0.0079 0.0079
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.0046 0.0111 0.0111
Echinococcus granulosus transient receptor potential cation channel 0.0039 0.0086 0.0086
Toxoplasma gondii exonuclease III APE 0.0058 0.0153 0.0925
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0039 0.0086 0.064
Echinococcus granulosus G protein coupled receptor 139 0.0037 0.0079 0.0079
Schistosoma mansoni cellular tumor antigen P53 0.0052 0.0131 0.0131
Loa Loa (eye worm) hypothetical protein 0.0037 0.0079 0.0079
Echinococcus multilocularis cAMP dependent protein kinase regulatory 0.0044 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.0473 0.1652 0.1652
Echinococcus granulosus tachykinin peptides receptor 99D 0.0037 0.0079 0.0079
Echinococcus granulosus hyperpolarization activated cyclic 0.0083 0.0244 0.0244
Loa Loa (eye worm) hypothetical protein 0.0037 0.0079 0.0079
Echinococcus multilocularis ryanodine receptor 44f 0.0039 0.0086 0.0086
Schistosoma mansoni voltage-gated potassium channel 0.0039 0.0086 0.0086
Brugia malayi hypothetical protein 0.0037 0.0079 0.0079
Onchocerca volvulus 0.0028 0.0047 0.0047
Echinococcus multilocularis hyperpolarization activated cyclic 0.0083 0.0244 0.0244
Trypanosoma brucei cytochrome P450, putative 0.0024 0.0031 0.023
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0025 0.0033 0.0033
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0037 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0037 0.0079 0.0079
Schistosoma mansoni neuropeptide F-like receptor 0.0037 0.0079 0.0079
Echinococcus multilocularis g-protein coupled receptor 0.0037 0.0079 0.0079
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0039 0.0086 0.0086
Trypanosoma brucei STE group serine/threonine-protein kinase, putative 0.0028 0.0045 0.0337
Echinococcus granulosus serotonin transporter 0.2788 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0045 0.0188
Trypanosoma cruzi cytochrome P450, putative 0.0024 0.0031 0.023
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0175 0.0175
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0058 0.0153 0.0776
Brugia malayi regulator of G-protein signaling rgs-7 0.002 0.0018 0.0018
Loa Loa (eye worm) neuropeptide F receptor 0.0037 0.0079 0.0079
Trichomonas vaginalis guanylate cyclase, putative 0.0028 0.0045 0.0188
Brugia malayi PXA domain containing protein 0.002 0.0018 0.0018
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0028 0.0045 0.0188
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0025 0.0033 0.0033
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0037 0.0079 0.0079
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0103 0.043
Trichomonas vaginalis cAMP-dependent protein kinase regulatory subunit, putative 0.0044 0.0103 0.043
Echinococcus granulosus voltage dependent calcium channel 0.0039 0.0086 0.0086
Echinococcus multilocularis orexin receptor type 2 0.0037 0.0079 0.0079
Leishmania major C-8 sterol isomerase-like protein 0.0387 0.1341 1
Brugia malayi hypothetical protein 0.0037 0.0079 0.0079
Plasmodium vivax hypothetical protein, conserved 0.0473 0.1652 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.107 0.3804 0.3804
Loa Loa (eye worm) hypothetical protein 0.0052 0.0131 0.0131
Echinococcus granulosus cAMP dependent protein kinase type I beta 0.0044 0.0103 0.0103
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0473 0.1652 0.1652
Loa Loa (eye worm) hypothetical protein 0.0037 0.0079 0.0079
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0473 0.1652 0.1652
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.044 0.1533 0.1533
Trichomonas vaginalis adenylate cyclase type, putative 0.0028 0.0045 0.0188
Onchocerca volvulus Neuropeptide F receptor homolog 0.0037 0.0079 0.0079
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0058 0.0153 0.0776
Loa Loa (eye worm) hypothetical protein 0.0037 0.0079 0.0079
Mycobacterium tuberculosis Probable conserved transmembrane transport protein 0.0044 0.0103 0.0525
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0045 0.0188
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0037 0.0079 0.0079
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0025 0.0033 0.0033
Echinococcus multilocularis transient receptor potential gamma protein 0.0039 0.0086 0.0086
Echinococcus multilocularis sodium and chloride dependent glycine 0.0473 0.1652 0.1652
Trypanosoma brucei cyclic nucleotide-binding domain containing protein, putative 0.0044 0.0103 0.0771
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0045 0.0188
Brugia malayi hypothetical protein 0.0037 0.0079 0.0079
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0473 0.1652 0.1652
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0046 0.0111 0.0111
Trypanosoma brucei protein kinase A regulatory subunit 0.0044 0.0103 0.0771
Echinococcus granulosus potassium voltage gated channel protein 0.0039 0.0086 0.0086
Echinococcus multilocularis g protein coupled receptor 0.0037 0.0079 0.0079
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0037 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0037 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0282 0.0962 0.0962
Brugia malayi aryl hydrocarbon receptor nuclear translocator protein, putative 0.0028 0.0045 0.0045
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0037 0.0079 0.0079
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0037 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0037 0.0079 0.0079
Trichomonas vaginalis adenylate cyclase type, putative 0.0028 0.0045 0.0188
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0037 0.0079 0.0079
Echinococcus granulosus axis inhibition protein axin 0.002 0.0018 0.0018
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0018 0.0018
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.006 0.006
Schistosoma mansoni neuropeptide f receptor 76f 0.0037 0.0079 0.0079
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0473 0.1652 0.1652
Loa Loa (eye worm) hypothetical protein 0.0039 0.0086 0.0086
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0039 0.0086 0.0086
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0058 0.0153 0.114
Trypanosoma cruzi cAMP response protein 1 0.0044 0.0103 0.0771
Schistosoma mansoni amine GPCR 0.0037 0.0079 0.0079
Schistosoma mansoni regulator of G protein signaling 0.002 0.0018 0.0018
Echinococcus multilocularis rhodopsin orphan GPCR 0.0037 0.0079 0.0079
Echinococcus multilocularis expressed conserved protein 0.0044 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.0029 0.005 0.005
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0039 0.0086 0.0086
Schistosoma mansoni camp-dependent protein kinase type II-alpha regulatory subunit 0.0044 0.0103 0.0103
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0044 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.0037 0.0079 0.0079
Brugia malayi follicle stimulating hormone receptor 0.0037 0.0079 0.0079
Echinococcus multilocularis two pore calcium channel protein 1 0.0039 0.0086 0.0086
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0058 0.0153 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0086 0.0086
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0083 0.0244 0.0244
Brugia malayi Cation transporter family protein 0.0094 0.0284 0.0284
Toxoplasma gondii hypothetical protein 0.0473 0.1652 1
Echinococcus multilocularis metabotropic glutamate receptor 5 0.005 0.0125 0.0125
Echinococcus multilocularis transfer RNA-Gly 0.0039 0.0086 0.0086
Onchocerca volvulus 0.0064 0.0175 0.0175
Echinococcus granulosus somatostatin receptor 0.0037 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0037 0.0079 0.0079
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0037 0.0079 0.0079
Schistosoma mansoni z-protein (S1r protein) 0.0029 0.005 0.005
Brugia malayi exodeoxyribonuclease III family protein 0.0058 0.0153 0.0153
Echinococcus multilocularis two pore calcium channel protein 2 0.0039 0.0086 0.0086
Echinococcus multilocularis shaker cognate 0.0039 0.0086 0.0086
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0044 0.0103 0.0626
Echinococcus multilocularis beta adrenergic receptor kinase 0.002 0.0018 0.0018
Echinococcus multilocularis dnaJ subfamily B 0.0404 0.14 0.14
Loa Loa (eye worm) hypothetical protein 0.0037 0.0079 0.0079
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0044 0.0103 0.043
Loa Loa (eye worm) voltage-gated calcium channel 0.0039 0.0086 0.0086
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0045 0.0188
Echinococcus granulosus voltage dependent calcium channel 0.0039 0.0086 0.0086
Leishmania major hypothetical protein, conserved 0.0039 0.0086 0.064
Schistosoma mansoni voltage-gated potassium channel 0.0354 0.1221 0.1221
Echinococcus multilocularis rhodopsin orphan GPCR 0.0037 0.0079 0.0079
Schistosoma mansoni voltage-gated potassium channel 0.0111 0.0345 0.0345
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0861 0.3051 0.3051
Leishmania major cytochrome p450-like protein 0.0024 0.0031 0.023
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0039 0.0086 0.0086
Echinococcus granulosus transient receptor potential cation channel 0.0039 0.0086 0.0086
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0037 0.0079 0.0079
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.006 0.006
Trichomonas vaginalis guanylate cyclase, putative 0.0028 0.0045 0.0188
Echinococcus multilocularis sex peptide receptor 0.0037 0.0079 0.0079
Echinococcus multilocularis regulator of G protein signaling 7 0.0029 0.005 0.005
Schistosoma mansoni ap endonuclease 0.0058 0.0153 0.0153
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0037 0.0079 0.0079
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0025 0.0033 0.0033
Toxoplasma gondii hypothetical protein 0.0039 0.0086 0.052
Loa Loa (eye worm) hypothetical protein 0.0025 0.0033 0.0033
Echinococcus granulosus metabotropic glutamate receptor 2 0.0034 0.0067 0.0067
Schistosoma mansoni amine GPCR 0.0037 0.0079 0.0079
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0025 0.0033 0.0033
Schistosoma mansoni hypothetical protein 0.0404 0.14 0.14
Echinococcus multilocularis G-protein coupled receptor, putative 0.0037 0.0079 0.0079
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0039 0.0086 0.0086
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0326 0.112 0.112
Schistosoma mansoni 60S ribosomal protein L21 0.0067 0.0186 0.0186
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0058 0.0153 1
Trichomonas vaginalis adenylate cyclase, putative 0.0028 0.0045 0.0188
Echinococcus multilocularis dro:myosuppressin receptor 0.0037 0.0079 0.0079
Mycobacterium ulcerans hypothetical protein 0.0044 0.0103 0.0525
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0037 0.0226
Schistosoma mansoni biogenic amine (5HT) receptor 0.0037 0.0079 0.0079
Schistosoma mansoni nAChR subunit 0.0025 0.0033 0.0033
Leishmania major protein kinase A regulatory subunit, putative 0.0044 0.0103 0.0771
Echinococcus granulosus cAMP dependent protein kinase type II regulatory 0.0044 0.0103 0.0103
Echinococcus granulosus g protein coupled receptor 0.0037 0.0079 0.0079
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0473 0.1652 0.1652
Treponema pallidum exodeoxyribonuclease (exoA) 0.0058 0.0153 0.005
Trypanosoma cruzi cyclic nucleotide-binding domain containing protein, putative 0.0044 0.0103 0.0771
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0025 0.0033 0.0033
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.0044 0.0103 0.0103
Echinococcus granulosus TRP transient receptor potential channel 0.0039 0.0086 0.0086
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0018 0.0018
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0028 0.0045 0.0188
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0025 0.0033 0.0033
Brugia malayi neuropeptide F receptor 0.0037 0.0079 0.0079
Schistosoma mansoni hypothetical protein 0.0039 0.0086 0.0086
Onchocerca volvulus 0.0473 0.1652 0.1652
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0037 0.0079 0.0079
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0083 0.0244 0.0244
Brugia malayi G-protein coupled receptor 0.0037 0.0079 0.0079
Brugia malayi hypothetical protein 0.002 0.0018 0.0018
Trichomonas vaginalis adenylate cyclase, putative 0.0028 0.0045 0.0188
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0473 0.1652 0.1652
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0039 0.0086 0.0086
Echinococcus granulosus rhodopsin orphan GPCR 0.0037 0.0079 0.0079
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0058 0.0153 0.114
Onchocerca volvulus 0.0094 0.0284 0.0284
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0037 0.0079 0.0079
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0039 0.0086 0.0086
Echinococcus multilocularis g protein coupled receptor 0.0037 0.0079 0.0079
Echinococcus granulosus transient receptor potential cation channel 0.0039 0.0086 0.0086
Echinococcus granulosus potassium voltage gated channel protein 0.0039 0.0086 0.0086
Loa Loa (eye worm) hypothetical protein 0.0037 0.0079 0.0079
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0018 0.0073
Schistosoma mansoni growth hormone secretagogue receptor 0.0037 0.0079 0.0079
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0037 0.0079 0.0079
Echinococcus multilocularis neuropeptide s receptor 0.0037 0.0079 0.0079
Trichomonas vaginalis adenylate cyclase, putative 0.0028 0.0045 0.0188
Schistosoma mansoni neuropeptide F-like receptor 0.0037 0.0079 0.0079
Echinococcus granulosus ryanodine receptor 44f 0.0039 0.0086 0.0086
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0058 0.0153 0.0153
Schistosoma mansoni transient receptor potential channel 0.0039 0.0086 0.0086
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0039 0.0086 0.0086
Brugia malayi Tachykinin-like peptides receptor 99D 0.0037 0.0079 0.0079
Schistosoma mansoni hypothetical protein 0.0037 0.0079 0.0079
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0025 0.0033 0.0033
Brugia malayi hypothetical protein 0.0037 0.0079 0.0079
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0039 0.0086 0.0086
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0083 0.0244 0.0244
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0094 0.0284 0.0284
Echinococcus multilocularis rhodopsin orphan GPCR 0.0037 0.0079 0.0079
Schistosoma mansoni voltage-gated potassium channel 0.0039 0.0086 0.0086
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0025 0.0033 0.0033
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0083 0.0244 0.0244
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0037 0.0079 0.0079
Echinococcus granulosus hypothetical protein 0.0037 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0037 0.0079 0.0079
Schistosoma mansoni voltage-gated potassium channel 0.0039 0.0086 0.0086
Schistosoma mansoni neuropeptide receptor 0.0037 0.0079 0.0079
Echinococcus granulosus glycine receptor subunit alpha 1 0.0025 0.0033 0.0033
Schistosoma mansoni amine GPCR 0.0037 0.0079 0.0079
Echinococcus granulosus peptide allatostatin:somatostatin 0.0037 0.0079 0.0079
Schistosoma mansoni voltage-gated potassium channel 0.0039 0.0086 0.0086
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0101 0.031 0.031
Loa Loa (eye worm) hypothetical protein 0.0039 0.0086 0.0086
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0473 0.1652 0.1652
Schistosoma mansoni voltage-gated potassium channel 0.0067 0.0186 0.0186
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.0039 0.0086 0.064
Loa Loa (eye worm) hypothetical protein 0.0039 0.0086 0.0086
Brugia malayi Pre-SET motif family protein 0.044 0.1533 0.1533
Schistosoma mansoni hypothetical protein 0.0032 0.006 0.006
Schistosoma mansoni biogenic amine receptor 0.0037 0.0079 0.0079
Echinococcus multilocularis transient receptor potential cation channel 0.0039 0.0086 0.0086
Loa Loa (eye worm) hypothetical protein 0.002 0.0018 0.0018
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0044 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.0064 0.0175 0.0175
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0083 0.0244 0.0244
Loa Loa (eye worm) hypothetical protein 0.0025 0.0033 0.0033
Echinococcus multilocularis tumor protein p63 0.0353 0.1219 0.1219
Echinococcus granulosus expressed protein 0.0392 0.136 0.136
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0037 0.0278
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0037 0.0079 0.0079
Onchocerca volvulus 0.0037 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0039 0.0086 0.0086
Trypanosoma cruzi Flagellar Member 6 0.0044 0.0103 0.0771
Schistosoma mansoni hypothetical protein 0.0032 0.006 0.006
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0058 0.0153 0.114
Schistosoma mansoni hypothetical protein 0.0349 0.1204 0.1204
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0039 0.0086 0.0086
Leishmania major hypothetical protein, unknown function 0.0039 0.0086 0.064
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0037 0.0079 0.0079
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0025 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0223 0.0751 0.0751
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0473 0.1652 0.1652
Schistosoma mansoni transient receptor potential channel 0.0039 0.0086 0.0086
Echinococcus granulosus hypothetical protein 0.0039 0.0086 0.0086
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0039 0.0086 0.0086
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0094 0.0284 0.0284
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0039 0.0086 0.0086
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0025 0.0033 0.0033
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0037 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0083 0.0244 0.0244
Mycobacterium tuberculosis Probable glutamine-transport ATP-binding protein ABC transporter GlnQ 0.0044 0.0103 0.0525
Schistosoma mansoni nAChR subunit 0.0025 0.0033 0.0033
Toxoplasma gondii transporter, cation channel family protein 0.0039 0.0086 0.052
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0287 0.0979 0.4078
Schistosoma mansoni hypothetical protein 0.0032 0.006 0.006
Loa Loa (eye worm) hypothetical protein 0.002 0.0018 0.0018
Echinococcus granulosus alpha 1A adrenergic receptor 0.0037 0.0079 0.0079
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0037 0.0079 0.0079
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0083 0.0244 0.0244
Loa Loa (eye worm) hypothetical protein 0.0037 0.0079 0.0079
Schistosoma mansoni metabotropic glutamate receptor 0.0034 0.0067 0.0067
Trichomonas vaginalis guanylate cyclase, putative 0.0028 0.0045 0.0188
Brugia malayi GnHR receptor homolog 0.0037 0.0079 0.0079
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0473 0.1652 0.1652
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0025 0.0033 0.0033
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0025 0.0033 0.0033
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0025 0.0033 0.0033
Toxoplasma gondii cAMP-dependent protein kinase regulatory subunit 0.0044 0.0103 0.0626
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0061 0.0164 0.0164
Loa Loa (eye worm) hypothetical protein 0.0025 0.0033 0.0033
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0037 0.0079 0.0079
Echinococcus multilocularis serotonin receptor 0.0037 0.0079 0.0079
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0039 0.0086 0.052
Schistosoma mansoni cpg binding protein 0.003 0.0053 0.0053
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.006 0.006
Schistosoma mansoni sodium/chloride dependent transporter 0.0473 0.1652 0.1652
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0473 0.1652 0.1652
Schistosoma mansoni cyclic nucleotide-gated ion channel 0.0044 0.0103 0.0103
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0037 0.0079 0.0079
Echinococcus multilocularis rhodopsin orphan GPCR 0.0037 0.0079 0.0079
Brugia malayi cAMP-dependent protein kinase regulatory chain, putative 0.0044 0.0103 0.0103
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0028 0.0045 0.0188
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0037 0.0079 0.0079
Toxoplasma gondii hypothetical protein 0.0039 0.0086 0.052
Loa Loa (eye worm) hypothetical protein 0.0039 0.0086 0.0086
Treponema pallidum sodium- and chloride- dependent transporter 0.2788 1 1
Trypanosoma cruzi regulatory subunit of protein kinase a-like protein, putative 0.0044 0.0103 0.0771
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0039 0.0086 0.0086
Echinococcus multilocularis potassium voltage gated channel protein 0.0039 0.0086 0.0086
Loa Loa (eye worm) hypothetical protein 0.0037 0.0079 0.0079
Trichomonas vaginalis guanylate cyclase, putative 0.0028 0.0045 0.0188
Onchocerca volvulus 0.0052 0.0131 0.0131
Loa Loa (eye worm) hypothetical protein 0.0037 0.0079 0.0079
Loa Loa (eye worm) AGC/PKG protein kinase 0.0044 0.0103 0.0103
Loa Loa (eye worm) ryanodine receptor 0.0039 0.0086 0.0086
Trichomonas vaginalis adenylate cyclase, putative 0.0028 0.0045 0.0188
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0025 0.0033 0.0033
Echinococcus granulosus dnaJ subfamily B 0.0404 0.14 0.14
Echinococcus multilocularis G protein coupled receptor 139 0.0037 0.0079 0.0079
Echinococcus granulosus neuropeptide FF receptor 2 0.0037 0.0079 0.0079
Brugia malayi Cyclic-nucleotide gated cation channel 0.0083 0.0244 0.0244
Trypanosoma cruzi cytochrome P450, putative 0.0024 0.0031 0.023
Echinococcus granulosus sodium leak channel non selective protein 0.0039 0.0086 0.0086
Loa Loa (eye worm) hypothetical protein 0.0037 0.0079 0.0079
Loa Loa (eye worm) solute carrier family 6 member 4 0.2788 1 1
Plasmodium falciparum cAMP-dependent protein kinase regulatory subunit 0.0044 0.0103 0.0626
Echinococcus granulosus GPCR family 2 0.0032 0.006 0.006
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0039 0.0086 0.0086
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0018 0.0018
Schistosoma mansoni voltage-gated potassium channel 0.0039 0.0086 0.0086
Loa Loa (eye worm) hypothetical protein 0.0037 0.0079 0.0079
Brugia malayi hypothetical protein 0.0017 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.002 0.0018 0.0018
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0037 0.0079 0.0079
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0473 0.1652 1
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0473 0.1652 1
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0025 0.0033 0.0033
Echinococcus granulosus geminin 0.0349 0.1204 0.1204
Loa Loa (eye worm) CYP4Cod1 0.0024 0.0031 0.0031
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0039 0.0086 0.0086
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0387 0.1341 1
Brugia malayi neuropeptide F receptor 0.0037 0.0079 0.0079
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0064 0.0175 0.1057
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0025 0.0033 0.0033
Echinococcus multilocularis transient receptor potential cation channel 0.0039 0.0086 0.0086
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0025 0.0033 0.0033
Leishmania major cyclic nucleotide-binding protein-like protein 0.0044 0.0103 0.0771
Echinococcus multilocularis neuropeptide receptor 0.0037 0.0079 0.0079
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0025 0.0033 0.0033
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0037 0.0226
Leishmania major hypothetical protein, conserved 0.0044 0.0103 0.0771
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.0039 0.0086 0.0086
Loa Loa (eye worm) voltage-dependent calcium channel 0.0039 0.0086 0.0086
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0028 0.0045 0.0188
Schistosoma mansoni cpg binding protein 0.003 0.0053 0.0053
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0037 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0025 0.0033 0.0033
Schistosoma mansoni hypothetical protein 0.0037 0.0079 0.0079
Trichomonas vaginalis conserved hypothetical protein 0.0681 0.2401 1
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0025 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0037 0.0079 0.0079
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0039 0.0086 0.0086
Echinococcus granulosus neuropeptide receptor A26 0.0037 0.0079 0.0079
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0025 0.0033 0.0033
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0039 0.0086 0.0086
Mycobacterium tuberculosis Conserved hypothetical protein 0.0044 0.0103 0.0525
Echinococcus granulosus fmrfamide receptor 0.0037 0.0079 0.0079
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0103 0.0771
Loa Loa (eye worm) ACC-1 protein 0.0025 0.0033 0.0033
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0058 0.0153 0.0153
Trypanosoma brucei cyclic nucleotide-binding domain containing protein, putative 0.0044 0.0103 0.0771
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0025 0.0033 0.0033
Schistosoma mansoni opsin-like receptor 0.0037 0.0079 0.0079
Echinococcus multilocularis g protein coupled receptor 0.0037 0.0079 0.0079
Loa Loa (eye worm) LGC-31 protein 0.0025 0.0033 0.0033
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0037 0.0079 0.0079
Entamoeba histolytica hypothetical protein 0.002 0.0018 0.1149
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0473 0.1652 0.1652
Brugia malayi Cyclic-nucleotide gated cation channel, C. elegans tax-4 ortholog 0.0044 0.0103 0.0103
Echinococcus granulosus neuropeptide receptor 0.0037 0.0079 0.0079
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0037 0.0077 0.0077
Echinococcus granulosus calcium activated potassium channel 0.0039 0.0086 0.0086
Trichomonas vaginalis adenylate cyclase, putative 0.0028 0.0045 0.0188
Echinococcus granulosus allatostatin A receptor 0.0037 0.0079 0.0079
Echinococcus granulosus neuropeptide Y receptor 0.0037 0.0079 0.0079
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0039 0.0086 0.0086
Trichomonas vaginalis hypothetical protein 0.0028 0.0045 0.0188
Brugia malayi hypothetical protein 0.0037 0.0079 0.0079
Echinococcus multilocularis GPCR, family 2 0.0032 0.006 0.006
Leishmania major hypothetical protein, conserved 0.0044 0.0103 0.0771
Trichomonas vaginalis adenylate cyclase, putative 0.0028 0.0045 0.0188
Mycobacterium ulcerans regulatory protein 0.0044 0.0103 0.0525
Loa Loa (eye worm) hypothetical protein 0.0025 0.0033 0.0033
Schistosoma mansoni nAChR subunit 0.0025 0.0033 0.0033
Leishmania major hypothetical protein, conserved 0.0026 0.0037 0.0278
Trichomonas vaginalis cAMP-dependent protein kinase type I-beta regulatory subunit, putative 0.0044 0.0103 0.043
Loa Loa (eye worm) calcium channel 0.0039 0.0086 0.0086
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0083 0.0244 0.0244
Toxoplasma gondii transporter, cation channel family protein 0.0039 0.0086 0.052
Loa Loa (eye worm) hypothetical protein 0.0473 0.1652 0.1652
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0045 0.0188
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0037 0.0079 0.0079
Trichomonas vaginalis adenylate cyclase, putative 0.0028 0.0045 0.0188
Loa Loa (eye worm) hypothetical protein 0.0037 0.0079 0.0079
Onchocerca volvulus 0.0025 0.0033 0.0033
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0018 0.0073
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0473 0.1652 0.1652
Loa Loa (eye worm) hypothetical protein 0.0044 0.0103 0.0103
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0287 0.0979 0.4078
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0018 0.0018
Echinococcus multilocularis short transient receptor potential channel 6 0.0039 0.0086 0.0086
Loa Loa (eye worm) hypothetical protein 0.0037 0.0079 0.0079
Brugia malayi Hypothetical UPF0028 protein ZK370.4 in chromosome III, putative 0.0044 0.0103 0.0103
Trypanosoma cruzi cAMP response protein 1, putative 0.0044 0.0103 0.0771
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.002 0.0018 0.0018
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0025 0.0033 0.0033
Schistosoma mansoni regulator of G protein signaling 0.002 0.0018 0.0018
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0111 0.0345 0.0345
Schistosoma mansoni voltage-gated potassium channel 0.0039 0.0086 0.0086
Trichomonas vaginalis adenylyl cyclase type V, putative 0.0028 0.0045 0.0188
Brugia malayi G-protein coupled receptor 0.0037 0.0079 0.0079
Echinococcus multilocularis neuropeptide receptor A26 0.0037 0.0079 0.0079
Trichomonas vaginalis ap endonuclease, putative 0.0058 0.0153 0.0636
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0039 0.0086 0.0086
Echinococcus multilocularis allatostatin A receptor 0.0037 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0037 0.0079 0.0079
Schistosoma mansoni hypothetical protein 0.0028 0.0045 0.0045
Trichomonas vaginalis guanylate cyclase, putative 0.0028 0.0045 0.0188
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0039 0.0086 0.0086
Loa Loa (eye worm) hypothetical protein 0.0039 0.0086 0.0086
Brugia malayi Dopamine receptor protein 1 0.0037 0.0079 0.0079
Schistosoma mansoni voltage-dependent calcium channel 0.0039 0.0086 0.0086
Loa Loa (eye worm) G-protein coupled receptor 0.0037 0.0079 0.0079
Schistosoma mansoni cpg binding protein 0.0028 0.0047 0.0047
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0039 0.0086 0.0086
Schistosoma mansoni neuropeptide receptor 0.0037 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0025 0.0033 0.0033
Brugia malayi hypothetical protein 0.0026 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0032 0.006 0.006
Loa Loa (eye worm) hypothetical protein 0.002 0.0018 0.0018
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0037 0.0079 0.0079
Brugia malayi Melatonin receptor type 1A 0.0037 0.0079 0.0079
Loa Loa (eye worm) RGS-3 protein 0.002 0.0018 0.0018
Onchocerca volvulus 0.0037 0.0079 0.0079
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0018 0.0073
Onchocerca volvulus 0.0044 0.0103 0.0103
Onchocerca volvulus 0.0037 0.0079 0.0079
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0039 0.0086 0.0086
Onchocerca volvulus 0.0037 0.0079 0.0079
Echinococcus granulosus two pore calcium channel protein 1 0.0039 0.0086 0.0086
Loa Loa (eye worm) hypothetical protein 0.0039 0.0086 0.0086
Loa Loa (eye worm) hypothetical protein 0.0037 0.0079 0.0079
Toxoplasma gondii hypothetical protein 0.0473 0.1652 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0039 0.0086 0.0086
Loa Loa (eye worm) hypothetical protein 0.0111 0.0345 0.0345
Schistosoma mansoni voltage-gated potassium channel 0.0039 0.0086 0.0086
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0025 0.0033 0.0033
Plasmodium vivax amine transporter, putative 0.0473 0.1652 1
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0037 0.0079 0.0079
Loa Loa (eye worm) serotonin transporter b 0.2788 1 1
Brugia malayi Cation transporter family protein 0.0025 0.0033 0.0033
Echinococcus granulosus dro:myosuppressin receptor 0.0037 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0025 0.0033 0.0033
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0039 0.0086 0.052
Echinococcus granulosus transient receptor potential cation channel 0.0039 0.0086 0.0086
Schistosoma mansoni voltage-gated potassium channel 0.0111 0.0345 0.0345
Loa Loa (eye worm) PXA domain-containing protein 0.002 0.0018 0.0018
Leishmania major regulatory subunit of protein kinase a-like protein 0.0044 0.0103 0.0771
Schistosoma mansoni amine GPCR 0.0037 0.0079 0.0079
Echinococcus multilocularis cAMP dependent protein kinase type I beta 0.0044 0.0103 0.0103
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0064 0.0175 0.0175
Onchocerca volvulus 0.2788 1 1
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0044 0.0103 0.0626
Echinococcus granulosus voltage gated potassium channel 0.0111 0.0345 0.0345
Schistosoma mansoni neuropeptide receptor 0.0037 0.0079 0.0079
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0037 0.0226
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0039 0.0086 0.0086
Leishmania major protein kinase, putative 0.0044 0.0103 0.0771
Loa Loa (eye worm) hypothetical protein 0.0039 0.0086 0.0086
Loa Loa (eye worm) hypothetical protein 0.0069 0.0195 0.0195
Brugia malayi Latrophilin receptor protein 2 0.0032 0.006 0.006
Loa Loa (eye worm) norepinephrine transporter 0.2788 1 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0079 0.0079
Schistosoma mansoni myosin xvIII 0.0037 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0025 0.0033 0.0033
Echinococcus multilocularis neuropeptides capa receptor 0.0037 0.0079 0.0079
Brugia malayi larval opioid receptor 0.0037 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.2788 1 1
Trypanosoma brucei C-8 sterol isomerase, putative 0.0387 0.1341 1
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0037 0.0079 0.0079
Trichomonas vaginalis guanylate cyclase, putative 0.0028 0.0045 0.0188
Echinococcus multilocularis potassium large conductance calcium activated 0.0039 0.0086 0.0086
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0473 0.1652 0.1652
Entamoeba histolytica hypothetical protein 0.002 0.0018 0.1149
Echinococcus granulosus single minded 2 0.0028 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0094 0.0284 0.0284
Brugia malayi ion channel NompC 0.0039 0.0086 0.0086
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0037 0.0079 0.0079
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0039 0.0086 0.0086
Brugia malayi hypothetical protein 0.002 0.0018 0.0018
Schistosoma mansoni voltage-gated potassium channel 0.0039 0.0086 0.0086
Echinococcus granulosus histone lysine methyltransferase setb 0.0064 0.0175 0.0175
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0028 0.0045 0.0188
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0039 0.0086 0.0086
Echinococcus multilocularis serotonin receptor 0.0037 0.0079 0.0079
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0083 0.0244 0.0244
Echinococcus granulosus regulator of G protein signaling 7 0.0029 0.005 0.005
Echinococcus multilocularis geminin 0.0349 0.1204 0.1204
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0025 0.0033 0.0033
Trichomonas vaginalis guanylate cyclase beta 1 subunit, putative 0.0028 0.0045 0.0188
Onchocerca volvulus 0.0473 0.1652 0.1652
Echinococcus multilocularis short transient receptor potential channel 6 0.0039 0.0086 0.0086
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0058 0.0153 1
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.002 0.0018 0.0073
Schistosoma mansoni sodium/chloride dependent transporter 0.2788 1 1
Schistosoma mansoni voltage-gated ion channel 0.0039 0.0086 0.0086
Trichomonas vaginalis guanylate cyclase, putative 0.0028 0.0045 0.0188
Loa Loa (eye worm) hypothetical protein 0.2788 1 1
Brugia malayi hypothetical protein 0.0037 0.0079 0.0079
Trichomonas vaginalis adenylate cyclase, putative 0.0028 0.0045 0.0188
Schistosoma mansoni vesicular amine transporter 0.0039 0.0086 0.0086
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0058 0.0153 0.0153
Loa Loa (eye worm) voltage-gated potassium channel 0.0039 0.0086 0.0086
Brugia malayi Metabotropic glutamate receptor precursor. 0.0041 0.0091 0.0091
Echinococcus granulosus Regulator of G protein signaling 20 0.002 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0039 0.0086 0.0086
Echinococcus multilocularis somatostatin receptor 0.0037 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0025 0.0033 0.0033
Echinococcus granulosus sodium and chloride dependent glycine 0.0473 0.1652 0.1652
Echinococcus granulosus orexin receptor type 2 0.0037 0.0079 0.0079
Echinococcus granulosus axis inhibition protein axin 0.002 0.0018 0.0018
Echinococcus granulosus cGMP dependent protein kinase 1 0.0044 0.0103 0.0103
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0039 0.0086 0.0086
Onchocerca volvulus Putative nachr subunit 0.0025 0.0033 0.0033
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0044 0.0103 0.0626
Loa Loa (eye worm) hypothetical protein 0.005 0.0125 0.0125
Echinococcus multilocularis voltage gated potassium channel 0.0039 0.0086 0.0086
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0018 0.0073
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0473 0.1652 0.1652
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0039 0.0086 0.0086
Echinococcus granulosus rhodopsin orphan GPCR 0.0037 0.0079 0.0079
Trichomonas vaginalis guanylate cyclase, putative 0.0028 0.0045 0.0188
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0024 0.0031 0.0156
Trichomonas vaginalis guanylate cyclase beta 2 subunit, putative 0.0028 0.0045 0.0188
Brugia malayi Dopamine receptor protein 2 0.0037 0.0079 0.0079
Echinococcus multilocularis regulator of G protein signaling 7 0.0029 0.005 0.005
Echinococcus granulosus nAChR subunit 0.0025 0.0033 0.0033
Echinococcus multilocularis cAMP dependent protein kinase type II regulatory 0.0044 0.0103 0.0103
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.002 0.0018 0.0018
Trichomonas vaginalis adenylate cyclase type III, putative 0.0028 0.0045 0.0188
Echinococcus granulosus regulator of G protein signaling 7 0.0029 0.005 0.005
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.0039 0.0086 0.064
Leishmania major protein kinase, putative 0.0044 0.0103 0.0771
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0037 0.0079 0.0079
Schistosoma mansoni sodium/chloride dependent transporter 0.0473 0.1652 0.1652
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.002 0.0018 0.0018
Trichomonas vaginalis guanylate cyclase, putative 0.0028 0.0045 0.0188
Loa Loa (eye worm) hypothetical protein 0.0026 0.0037 0.0037
Mycobacterium leprae Conserved hypothetical protein 0.0044 0.0103 1
Onchocerca volvulus 0.0037 0.0079 0.0079
Schistosoma mansoni hypothetical protein 0.0349 0.1204 0.1204
Loa Loa (eye worm) ion channel NompC 0.0039 0.0086 0.0086
Loa Loa (eye worm) hypothetical protein 0.0037 0.0079 0.0079
Echinococcus granulosus transient receptor potential cation channel 0.0039 0.0086 0.0086
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0037 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0037 0.0079 0.0079
Brugia malayi hypothetical protein 0.0037 0.0079 0.0079
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.002 0.0018 0.0018
Onchocerca volvulus 0.0039 0.0086 0.0086
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0037 0.0079 0.0079
Mycobacterium ulcerans hypothetical protein 0.0044 0.0103 0.0525
Echinococcus multilocularis sodium channel protein 0.0039 0.0086 0.0086
Schistosoma mansoni opsin-like receptor 0.0037 0.0079 0.0079
Plasmodium vivax rap guanine nucleotide exchange factor, putative 0.0044 0.0103 0.0626
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0037 0.0079 0.0079
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0039 0.0086 0.0086
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0018 0.0018
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0058 0.0153 0.0925
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0039 0.0086 0.0086
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0028 0.0045 0.0188
Trichomonas vaginalis guanylate cyclase, putative 0.0028 0.0045 0.0188
Loa Loa (eye worm) hypothetical protein 0.0037 0.0079 0.0079
Brugia malayi AKH receptor 0.0037 0.0079 0.0079
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0037 0.0079 0.0079
Echinococcus granulosus glycine receptor subunit alpha 1 0.0025 0.0033 0.0033
Onchocerca volvulus 0.0094 0.0284 0.0284
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0018 0.0018
Schistosoma mansoni regulator of G protein signaling 0.002 0.0018 0.0018
Brugia malayi excitatory GABA receptor EXP-1A 0.0025 0.0033 0.0033
Schistosoma mansoni nAChR subunit 0.0025 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0101 0.031 0.031
Echinococcus granulosus neuropeptides capa receptor 0.0037 0.0079 0.0079
Plasmodium vivax SET domain protein, putative 0.0064 0.0175 0.1057
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0037 0.0079 0.0079
Echinococcus granulosus tm gpcr rhodopsin 0.107 0.3804 0.3804
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0037 0.0079 0.0079
Brugia malayi Cation transporter family protein 0.0025 0.0033 0.0033
Mycobacterium tuberculosis Conserved hypothetical protein 0.0044 0.0103 0.0525
Schistosoma mansoni regulator of G protein signaling 0.0029 0.005 0.005
Echinococcus multilocularis neuropeptides capa receptor 0.0037 0.0079 0.0079
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0101 0.031 0.031
Trypanosoma cruzi protein kinase A regulatory subunit 0.0044 0.0103 0.0771
Echinococcus multilocularis cpg binding protein 0.003 0.0053 0.0053
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.0039 0.0086 0.0086
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0083 0.0244 0.0244
Trichomonas vaginalis adenylate cyclase, putative 0.0028 0.0045 0.0188
Plasmodium falciparum cGMP-dependent protein kinase 0.0044 0.0103 0.0626
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0037 0.0079 0.0079
Schistosoma mansoni voltage-gated potassium channel 0.0039 0.0086 0.0086
Echinococcus multilocularis nAChR subunit 0.0025 0.0033 0.0033
Mycobacterium ulcerans transcriptional regulatory protein 0.0044 0.0103 0.0525
Schistosoma mansoni similar to Protein C20orf152 homolog 0.0044 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.0037 0.0079 0.0079
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0018 0.0018
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0037 0.0079 0.0079
Echinococcus multilocularis conserved hypothetical protein 0.0039 0.0086 0.0086
Echinococcus granulosus neuropeptide s receptor 0.0037 0.0079 0.0079
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0028 0.0045 0.0188
Schistosoma mansoni neuropeptide receptor 0.0037 0.0079 0.0079
Echinococcus multilocularis sodium and chloride dependent glycine 0.0473 0.1652 0.1652
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0018 0.0018
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0037 0.0079 0.0079
Trichomonas vaginalis guanylate cyclase, putative 0.0028 0.0045 0.0188
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0029 0.005 0.005
Echinococcus multilocularis voltage dependent calcium channel 0.0039 0.0086 0.0086
Echinococcus multilocularis rhodopsin orphan GPCR 0.0037 0.0079 0.0079
Trichomonas vaginalis adenylate cyclase, putative 0.0028 0.0045 0.0188
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0037 0.0278
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0045 0.0188
Loa Loa (eye worm) hypothetical protein 0.0039 0.0086 0.0086
Echinococcus granulosus shaker cognate 0.0039 0.0086 0.0086
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0037 0.0079 0.0079
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0039 0.0086 0.0086
Loa Loa (eye worm) hypothetical protein 0.0473 0.1652 0.1652
Trichomonas vaginalis intestinal guanylate cyclase, putative 0.0028 0.0045 0.0188
Schistosoma mansoni axis inhibition protein axin 0.002 0.0018 0.0018
Echinococcus multilocularis transient receptor potential cation channel 0.0039 0.0086 0.0086
Echinococcus multilocularis Regulator of G protein signaling 20 0.002 0.0018 0.0018
Schistosoma mansoni serine/threonine protein kinase 0.0044 0.0103 0.0103
Trichomonas vaginalis adenylate cyclase type IX, putative 0.0028 0.0045 0.0188
Loa Loa (eye worm) hypothetical protein 0.0473 0.1652 0.1652
Echinococcus multilocularis transient receptor potential cation channel 0.0039 0.0086 0.0086
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0058 0.0153 0.114
Echinococcus granulosus potassium large conductance calcium activated 0.0039 0.0086 0.0086
Schistosoma mansoni nAChR subunit 0.0025 0.0033 0.0033

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) = 1 % Modulation of human recombinant adenosine A2A receptor expressed in CHO cells assessed as increase in NECA-induced intracellular [3H]-cAMP production at 10 uM incubated for 15 mins prior to NECA induction measured after 30 mins by liquid scintillation spectrometric analysis ChEMBL. 24077183
Activity (binding) = 9.2 % Agonist activity at human recombinant adenosine A2A receptor expressed in CHO cells assessed as increase in intracellular [3H]-cAMP production at 10 uM measured after 15 mins by liquid scintillation spectrometric analysis relative to NECA ChEMBL. 24077183
IC50 (functional) = 291.4 nM Antagonist activity at human recombinant adenosine A1 receptor expressed in CHO cells assessed as inhibition of NECA-mediated reduction of intracellular [3H]-cAMP accumulation incubated for 15 mins prior to NECA induction measured after 30 mins by liquid scintillation spectrometric analysis in presence of forskolin ChEMBL. 24077183
Ki (binding) = 343 nM Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cell membrane after 180 mins ChEMBL. 24077183
Ki (binding) > 1000 nM Displacement of [125I]AB-MECA from human adenosine A3 receptor expressed in CHO cell membrane after 90 mins ChEMBL. 24077183
Ki (binding) > 10000 nM Displacement of [3H]NECA from human adenosine A2A receptor expressed in CHO cell membrane after 90 mins ChEMBL. 24077183

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.