Detailed information for compound 1800280

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 387.445 | Formula: C22H26FNO4
  • H donors: 3 H acceptors: 5 LogP: 3.17 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O[C@H](C[C@@H](/C=C/c1c(nc(cc1c1ccc(cc1)F)C)C(C)C)O)CC(=O)O
  • InChi: 1S/C22H26FNO4/c1-13(2)22-19(9-8-17(25)11-18(26)12-21(27)28)20(10-14(3)24-22)15-4-6-16(23)7-5-15/h4-10,13,17-18,25-26H,11-12H2,1-3H3,(H,27,28)/b9-8+/t17-,18-/m1/s1
  • InChiKey: TUMBKYLZWRRFED-RKQNLGICSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis glycogen phosphorylase 0.0334 0.0326 0.0324
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0467 0.0468 0.0467
Loa Loa (eye worm) TAR-binding protein 0.0066 0.0039 0.0039
Brugia malayi Trehalase family protein 0.0134 0.0111 0.0111
Schistosoma mansoni lamin 0.0056 0.0028 0.0029
Trichomonas vaginalis alpha-glucosidase, putative 0.2137 0.2259 0.3366
Brugia malayi glutathione reductase 0.0047 0.0018 0.0018
Schistosoma mansoni mannosidase alpha class 2a 0.0095 0.007 0.0075
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.2137 0.2259 0.3366
Loa Loa (eye worm) TRE-1 protein 0.0134 0.0111 0.0111
Trichomonas vaginalis glucosylceramidase, putative 0.6284 0.6705 1
Loa Loa (eye worm) trehalase 0.0134 0.0111 0.0111
Schistosoma mansoni hypothetical protein 0.0131 0.0108 0.0118
Loa Loa (eye worm) hypothetical protein 0.0396 0.0392 0.0392
Echinococcus granulosus ceramide glucosyltransferase 0.1476 0.155 0.1548
Trichomonas vaginalis glycoside hydrolases, putative 0.0672 0.0688 0.1021
Schistosoma mansoni mannosyl-oligosaccharide alpha-12-mannosidase 0.0101 0.0076 0.0082
Loa Loa (eye worm) hypothetical protein 0.0729 0.075 0.075
Loa Loa (eye worm) trehalase 0.0134 0.0111 0.0111
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0051 0.0022 0.0022
Onchocerca volvulus 0.0134 0.0111 0.0119
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.0036 0.0038
Brugia malayi Mannosyl-oligosaccharide alpha-1,2-mannosidase isoform 1 0.0101 0.0076 0.0076
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.1968 0.2077 0.9192
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.1062 0.1106 0.1552
Trichomonas vaginalis endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative 0.0101 0.0076 0.0107
Loa Loa (eye worm) hypothetical protein 0.0034 0.0005 0.0005
Brugia malayi Melibiase family protein 0.0396 0.0392 0.0392
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0065 0.0038 0.0036
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.0008 0.0006
Loa Loa (eye worm) hypothetical protein 0.0061 0.0033 0.0033
Loa Loa (eye worm) manba-prov protein 0.0078 0.0051 0.0051
Trichomonas vaginalis glucosylceramidase, putative 0.4211 0.4482 0.6683
Echinococcus granulosus transcription factor Dp 1 0.0038 0.0008 0.0006
Echinococcus multilocularis lysosomal alpha glucosidase 0.9358 1 1
Trichomonas vaginalis alpha-L-fucosidase, putative 0.2317 0.2452 0.3653
Trichomonas vaginalis maltase-glucoamylase, putative 0.2137 0.2259 0.3366
Trichomonas vaginalis endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative 0.0101 0.0076 0.0107
Plasmodium vivax hypothetical protein, conserved 0.041 0.0407 1
Trichomonas vaginalis alpha-mannosidase 2c1, putative 0.0089 0.0064 0.0089
Mycobacterium tuberculosis Probable oxidoreductase 0.0118 0.0095 0.0833
Echinococcus multilocularis mannosyl oligosaccharide 1,2 alpha mannosidase 0.0101 0.0076 0.0074
Schistosoma mansoni alpha-glucosidase 0.8453 0.9029 1
Schistosoma mansoni lamin 0.0056 0.0028 0.0029
Schistosoma mansoni bile acid beta-glucosidase-related 0.108 0.1126 0.1245
Loa Loa (eye worm) hypothetical protein 0.0134 0.0111 0.0111
Trichomonas vaginalis conserved hypothetical protein 0.0134 0.0111 0.016
Echinococcus granulosus lysosomal alpha mannosidase 0.0134 0.0112 0.011
Brugia malayi Beta-glucuronidase precursor 0.0279 0.0267 0.0267
Echinococcus multilocularis endoplasmic reticulum mannosyl oligosaccharide 0.0101 0.0076 0.0074
Trichomonas vaginalis glucosylceramidase, putative 0.4304 0.4582 0.6832
Loa Loa (eye worm) intermediate filament protein 0.0056 0.0028 0.0028
Brugia malayi Thioredoxin reductase 0.0047 0.0018 0.0018
Schistosoma mansoni hypothetical protein 0.0034 0.0004 0.0002
Loa Loa (eye worm) hypothetical protein 0.0095 0.007 0.007
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0467 0.0468 0.0517
Echinococcus granulosus beta galactosidase 0.1299 0.1361 0.1359
Onchocerca volvulus Glycogen phosphorylase homolog 0.0334 0.0326 0.0428
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0051 0.0022 0.0019
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.2137 0.2259 0.3366
Echinococcus granulosus mitogen activated protein kinase 3 0.0051 0.0022 0.002
Entamoeba histolytica glycogen debranching enzyme, putative 0.0518 0.0523 0.2303
Echinococcus granulosus mannosyl oligosaccharide 12 alpha mannosidase 0.0101 0.0076 0.0074
Trichomonas vaginalis alpha-glucosidase, putative 0.2137 0.2259 0.3366
Brugia malayi Intermediate filament tail domain containing protein 0.0056 0.0028 0.0028
Brugia malayi Ceramide glucosyltransferase 0.1476 0.155 0.155
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0467 0.0468 0.0467
Brugia malayi hypothetical protein 0.0046 0.0017 0.0017
Trichomonas vaginalis glycogen phosphorylase, putative 0.0334 0.0326 0.048
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0039 0.0041
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0107 0.0082 0.0695
Echinococcus granulosus fucosidase alpha L 1 tissue 0.6668 0.7117 0.7116
Trichomonas vaginalis glycogen debranching enzyme, putative 0.0518 0.0523 0.0775
Schistosoma mansoni hypothetical protein 0.0374 0.0369 0.0407
Brugia malayi Glycosyl hydrolases family 38 protein 0.015 0.0129 0.0129
Echinococcus multilocularis glycogen phosphorylase 0.0334 0.0326 0.0324
Toxoplasma gondii Amylo-alpha-1,6-glucosidase 0.0518 0.0523 0.2255
Schistosoma mansoni hypothetical protein 0.0617 0.0629 0.0695
Trichomonas vaginalis glucosylceramidase, putative 0.4211 0.4482 0.6683
Brugia malayi Amylo-alpha-1,6-glucosidase family protein 0.0518 0.0523 0.0523
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0022 0.0027
Echinococcus multilocularis ceramide glucosyltransferase 0.1476 0.155 0.1548
Echinococcus multilocularis beta mannosidase 0.0078 0.0051 0.0049
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0038 0.0088
Loa Loa (eye worm) mannosidase 0.0101 0.0076 0.0076
Brugia malayi trehalase 0.0046 0.0017 0.0017
Onchocerca volvulus 0.0134 0.0111 0.0119
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0038 0.0088
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0065 0.0038 0.015
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0065 0.0038 0.0036
Trichomonas vaginalis alpha-L-fucosidase, putative 0.2317 0.2452 0.3653
Onchocerca volvulus 0.0095 0.007 0.006
Echinococcus granulosus alpha mannosidase 2 0.0034 0.0005 0.0003
Echinococcus granulosus Glycosyl transferase family 35 0.0334 0.0326 0.0324
Echinococcus multilocularis lysosomal alpha mannosidase 0.0134 0.0112 0.011
Trichomonas vaginalis conserved hypothetical protein 0.0266 0.0253 0.0372
Chlamydia trachomatis glycogen phosphorylase 0.0334 0.0326 0.5
Schistosoma mansoni glycogen phosphorylase 0.0334 0.0326 0.0359
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.2137 0.2259 1
Schistosoma mansoni thyroid hormone receptor 0.0141 0.0119 0.013
Trichomonas vaginalis endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative 0.0101 0.0076 0.0107
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0467 0.0468 0.0467
Trypanosoma cruzi hypothetical protein, conserved 0.2137 0.2259 1
Trichomonas vaginalis trehalase, putative 0.0134 0.0111 0.016
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.0022 0.0022
Trichomonas vaginalis glucosylceramidase, putative 0.6284 0.6705 1
Loa Loa (eye worm) hypothetical protein 0.0518 0.0523 0.0523
Trichomonas vaginalis alpha-mannosidase 2c1, putative 0.0084 0.0057 0.008
Onchocerca volvulus 0.0134 0.0111 0.0119
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.1062 0.1106 0.1645
Brugia malayi manba-prov protein 0.0357 0.035 0.035
Entamoeba histolytica glycogen phosphorylase, putative 0.0144 0.0122 0.0526
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0051 0.0022 0.0019
Trichomonas vaginalis mannosyl-oligosaccharide alpha-1,2-mannosidase, putative 0.0101 0.0076 0.0107
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0022 0.0019
Echinococcus multilocularis lamin 0.0056 0.0028 0.0026
Trichomonas vaginalis mannosyl-oligosaccharide alpha-1,2-mannosidase, putative 0.0101 0.0076 0.0107
Trichomonas vaginalis glucosylceramidase, putative 0.4211 0.4482 0.6683
Trichomonas vaginalis glucosylceramidase, putative 0.6284 0.6705 1
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0039 0.0041
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0051 0.0022 0.0019
Loa Loa (eye worm) trehalase 0.0134 0.0111 0.0111
Trichomonas vaginalis glucosylceramidase, putative 0.6284 0.6705 1
Trichomonas vaginalis glucosylceramidase, putative 0.4211 0.4482 0.6683
Entamoeba histolytica glycogen phosphorylase, putative 0.0334 0.0326 0.1427
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0022 0.0027
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0467 0.0468 0.0517
Loa Loa (eye worm) glycosyl hydrolase family 2 0.0302 0.0291 0.0291
Treponema pallidum hypothetical protein 0.0046 0.0017 0.5
Brugia malayi hypothetical protein 0.0046 0.0017 0.0017
Brugia malayi Trehalase family protein 0.0134 0.0111 0.0111
Brugia malayi hypothetical protein 0.0116 0.0092 0.0092
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0051 0.0022 0.0019
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0065 0.0038 0.0038
Trichomonas vaginalis glucosylceramidase, putative 0.4211 0.4482 0.6683
Trypanosoma brucei glucosidase, putative 0.2137 0.2259 1
Trichomonas vaginalis endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative 0.0101 0.0076 0.0107
Mycobacterium ulcerans alpha-L-fucosidase 0.6668 0.7117 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0107 0.0082 0.0695
Trichomonas vaginalis conserved hypothetical protein 0.0101 0.0076 0.0107
Onchocerca volvulus Trehalase homolog 0.0134 0.0111 0.0119
Loa Loa (eye worm) hypothetical protein 0.0134 0.0111 0.0111
Loa Loa (eye worm) hypothetical protein 0.0134 0.0111 0.0111
Echinococcus granulosus neutral alpha glucosidase AB 0.2137 0.2259 0.2258
Loa Loa (eye worm) glycosyl hydrolase family 38 protein 0.015 0.0129 0.0129
Brugia malayi trehalase I 0.0046 0.0017 0.0017
Echinococcus multilocularis alpha mannosidase 2 0.0095 0.007 0.0068
Schistosoma mansoni beta-mannosidase 0.0249 0.0235 0.0258
Trypanosoma brucei lysosomal alpha-mannosidase precursor, putative 0.0134 0.0112 0.0419
Trichomonas vaginalis mannosyl-oligosaccharide alpha-1,2-mannosidase, putative 0.0101 0.0076 0.0107
Loa Loa (eye worm) hypothetical protein 0.0095 0.007 0.007
Schistosoma mansoni lysosomal alpha-mannosidase (mannosidase alpha class 2b member 1) 0.0061 0.0033 0.0035
Entamoeba histolytica beta-galactosidase, putative 0.0473 0.0475 0.2088
Loa Loa (eye worm) alpha-L-fucosidase 0.5282 0.563 0.563
Trichomonas vaginalis alpha-glucosidase, putative 0.1062 0.1106 0.1645
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0396 0.0392 0.0432
Giardia lamblia 4-alpha-glucanotransferase, amylo-alpha-1,6-glucosidase 0.0518 0.0523 0.756
Brugia malayi Glycosyl hydrolases family 31 protein 0.1062 0.1106 0.1106
Entamoeba histolytica glycogenphosphorylase, putative 0.0144 0.0122 0.0526
Brugia malayi carbohydrate phosphorylase 0.0334 0.0326 0.0326
Trichomonas vaginalis alpha-mannosidase, putative 0.015 0.0129 0.0187
Echinococcus multilocularis neutral alpha glucosidase AB 0.2137 0.2259 0.2258
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0018 0.0016
Loa Loa (eye worm) hypothetical protein 0.0046 0.0017 0.0017
Brugia malayi lysosomal alpha-mannosidase 0.0095 0.007 0.007
Entamoeba histolytica alpha-1,2-mannosidase, putative 0.0908 0.0941 0.4156
Trichomonas vaginalis endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative 0.0101 0.0076 0.0107
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.1062 0.1106 0.4857
Loa Loa (eye worm) TRE-2 protein 0.0134 0.0111 0.0111
Loa Loa (eye worm) hypothetical protein 0.01 0.0075 0.0075
Brugia malayi Trehalase family protein 0.0134 0.0111 0.0111
Trypanosoma brucei glycosyl hydrolase-like protein 0.1062 0.1106 0.4857
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0065 0.0038 0.0038
Echinococcus multilocularis beta D xylosidase 2 0.0034 0.0004 0.0002
Echinococcus granulosus lysosomal alpha glucosidase 0.9358 1 1
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.6284 0.6705 0.6705
Trichomonas vaginalis glucosylceramidase, putative 0.4211 0.4482 0.6683
Trichomonas vaginalis glycogen phosphorylase, putative 0.0334 0.0326 0.048
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0056 0.0028 0.0028
Trichomonas vaginalis glucosylceramidase, putative 0.4211 0.4482 0.6683
Loa Loa (eye worm) beta-glucuronidase 0.0279 0.0267 0.0267
Loa Loa (eye worm) hypothetical protein 0.0034 0.0005 0.0005
Loa Loa (eye worm) trehalase 0.0046 0.0017 0.0017
Trichomonas vaginalis endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative 0.0101 0.0076 0.0107
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.2137 0.2259 0.2259
Loa Loa (eye worm) hypothetical protein 0.0046 0.0017 0.0017
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0039 0.0041
Brugia malayi Trehalase family protein 0.0134 0.0111 0.0111
Echinococcus granulosus dnaJ subfamily B 0.0428 0.0427 0.0425
Schistosoma mansoni glycogen phosphorylase 0.0144 0.0122 0.0134
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.0039 0.0039
Echinococcus multilocularis mitogen activated protein kinase 3 0.0051 0.0022 0.002
Loa Loa (eye worm) glutathione reductase 0.0047 0.0018 0.0018
Brugia malayi Glycosyl hydrolases family 31 protein 0.2137 0.2259 0.2259
Leishmania major glycosyl hydrolase-like protein 0.1062 0.1106 0.4857
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0065 0.0038 0.004
Onchocerca volvulus 0.6536 0.6975 1
Loa Loa (eye worm) hypothetical protein 0.0101 0.0076 0.0076
Echinococcus granulosus endoplasmic reticulum mannosyl oligosaccharide 0.0101 0.0076 0.0074
Echinococcus multilocularis beta galactosidase 0.1299 0.1361 0.1359
Trichomonas vaginalis glycogen debranching enzyme, putative 0.0518 0.0523 0.0775
Echinococcus multilocularis thyroid hormone receptor alpha 0.0141 0.0119 0.0117
Brugia malayi MAP kinase sur-1 0.0051 0.0022 0.0022
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0018 0.0018
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.2137 0.2259 1
Echinococcus multilocularis mitogen activated protein kinase 0.0051 0.0022 0.002
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0065 0.0038 0.0088
Echinococcus granulosus glycogen debranching enzyme 0.0518 0.0523 0.0522
Loa Loa (eye worm) hypothetical protein 0.0034 0.0005 0.0005
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0118 0.0095 0.0833
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0107 0.0082 0.0695
Onchocerca volvulus Ceramide glucosyltransferase homolog 0.1476 0.155 0.2191
Echinococcus multilocularis lamin dm0 0.0056 0.0028 0.0026
Trichomonas vaginalis alpha-glucosidase, putative 0.2137 0.2259 0.3366
Trypanosoma brucei protein kinase, putative 0.0051 0.0022 0.0019
Trichomonas vaginalis alpha-mannosidase 2c1, putative 0.015 0.0129 0.0187
Giardia lamblia Ceramide glucosyltransferase 0.0669 0.0685 1
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0131 0.0108 0.0106
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0022 0.0019
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.041 0.0407 1
Echinococcus granulosus glycogen phosphorylase 0.0334 0.0326 0.0324
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.1062 0.1106 0.4889
Echinococcus granulosus intermediate filament protein 0.0056 0.0028 0.0026
Trichomonas vaginalis glycoside hydrolase, putative 0.1067 0.1111 0.1653
Echinococcus multilocularis lysosomal alpha glucosidase 0.9358 1 1
Trichomonas vaginalis alpha-glucosidase, putative 0.2137 0.2259 0.3366
Loa Loa (eye worm) trehalase 0.0046 0.0017 0.0017
Giardia lamblia Glycogen phosphorylase 0.0334 0.0326 0.4581
Loa Loa (eye worm) amylo-alpha-1,6-glucosidase 0.0252 0.0238 0.0238
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0107 0.0082 0.0695
Loa Loa (eye worm) ceramide glucosyltransferase 0.1476 0.155 0.155
Echinococcus granulosus tar DNA binding protein 0.0066 0.0039 0.0037
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0022 0.0027
Echinococcus multilocularis expressed protein 0.0369 0.0363 0.0361
Trichomonas vaginalis endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative 0.0101 0.0076 0.0107
Echinococcus granulosus glycogen phosphorylase 0.0334 0.0326 0.0324
Loa Loa (eye worm) hypothetical protein 0.0056 0.0028 0.0028
Trichomonas vaginalis mannosyl-oligosaccharide alpha-1,2-mannosidase, putative 0.0101 0.0076 0.0107
Echinococcus multilocularis tar DNA binding protein 0.0066 0.0039 0.0037
Mycobacterium tuberculosis Probable reductase 0.0107 0.0082 0.0695
Schistosoma mansoni glycogen phosphorylase 0.0334 0.0326 0.0359
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0005 0.0001
Onchocerca volvulus Glucosylceramidase homolog 0.4211 0.4482 0.6412
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.1062 0.1106 0.4857
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0022 0.0027
Leishmania major alpha glucosidase II subunit, putative 0.2137 0.2259 1
Brugia malayi hypothetical protein 0.0134 0.0111 0.0111
Echinococcus granulosus expressed protein 0.0369 0.0363 0.0361
Brugia malayi RNA binding protein 0.0066 0.0039 0.0039
Onchocerca volvulus 0.0095 0.007 0.006
Schistosoma mansoni intermediate filament proteins 0.0056 0.0028 0.0029
Loa Loa (eye worm) glycogen phosphorylase 0.0334 0.0326 0.0326
Schistosoma mansoni lysosomal alpha-mannosidase (mannosidase alpha class 2b member 1) 0.0134 0.0112 0.0122
Trichomonas vaginalis glucosylceramidase, putative 0.6284 0.6705 1
Trichomonas vaginalis glucosylceramidase, putative 0.6284 0.6705 1
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0467 0.0468 0.0517
Echinococcus granulosus beta mannosidase 0.0078 0.0051 0.0049
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.6284 0.6705 0.6705
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.9358 1 1
Loa Loa (eye worm) hypothetical protein 0.0134 0.0111 0.0111
Trypanosoma cruzi hypothetical protein, conserved 0.2137 0.2259 1
Schistosoma mansoni thyroid hormone receptor 0.0141 0.0119 0.013
Brugia malayi TAR-binding protein 0.0066 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0046 0.0017 0.0017
Schistosoma mansoni hypothetical protein 0.0666 0.0682 0.0753
Brugia malayi Trehalase family protein 0.0046 0.0017 0.0017
Brugia malayi Trehalase family protein 0.0046 0.0017 0.0017
Entamoeba histolytica glycogen phosphorylase, putative 0.0144 0.0122 0.0526
Loa Loa (eye worm) hypothetical protein 0.0087 0.0061 0.0061
Trypanosoma cruzi lysosomal alpha-mannosidase precursor, putative 0.0134 0.0112 0.0419
Brugia malayi hypothetical protein 0.0046 0.0017 0.0017
Trypanosoma brucei lysosomal alpha-mannosidase precursor, putative 0.0106 0.0081 0.0282
Echinococcus granulosus mitogen activated protein kinase 0.0051 0.0022 0.002
Brugia malayi Glycosyl hydrolases family 38 protein 0.0095 0.007 0.007
Echinococcus multilocularis glycogen debranching enzyme 0.0518 0.0523 0.0522
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0038 0.0088
Loa Loa (eye worm) hypothetical protein 0.1062 0.1106 0.1106
Mycobacterium ulcerans alpha-mannosidase 0.015 0.0129 0.0176
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0029 0.0049
Trichomonas vaginalis beta-glucosidase, putative 0.0672 0.0688 0.1021
Trichomonas vaginalis glucosylceramidase, putative 0.4304 0.4582 0.6832
Schistosoma mansoni alpha-l-fucosidase 0.5282 0.563 0.6234
Trichomonas vaginalis maltase-glucoamylase, putative 0.1062 0.1106 0.1645
Schistosoma mansoni ceramide glucosyltransferase 0.1476 0.155 0.1715
Echinococcus multilocularis Glycosyl transferase, family 35 0.0334 0.0326 0.0324
Loa Loa (eye worm) hypothetical protein 0.0055 0.0027 0.0027
Echinococcus multilocularis dnaJ subfamily B 0.0428 0.0427 0.0425
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0396 0.0392 0.0432
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0118 0.0095 1
Loa Loa (eye worm) hypothetical protein 0.0134 0.0111 0.0111
Schistosoma mansoni bile acid beta-glucosidase-related 0.108 0.1126 0.1245
Trichomonas vaginalis alpha-glucosidase, putative 0.1062 0.1106 0.1645
Onchocerca volvulus 0.0134 0.0111 0.0119
Trichomonas vaginalis alpha-glucosidase, putative 0.1062 0.1106 0.1645
Brugia malayi Trehalase protein 5 0.0046 0.0017 0.0017
Echinococcus multilocularis bile acid beta glucosidase 0.108 0.1126 0.1124
Echinococcus granulosus non lysosomal glucosylceramidase 0.108 0.1126 0.1124
Loa Loa (eye worm) RNA binding protein 0.0066 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0087 0.0061 0.0061
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0039 0.0041
Mycobacterium tuberculosis Possible conserved exported protein 0.0908 0.0941 1
Mycobacterium tuberculosis Probable glycogen phosphorylase GlgP 0.0144 0.0122 0.1134
Schistosoma mansoni hypothetical protein 0.0428 0.0427 0.0471
Echinococcus multilocularis non lysosomal glucosylceramidase 0.108 0.1126 0.1124
Loa Loa (eye worm) hypothetical protein 0.1629 0.1714 0.1714
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0018 0.0016
Brugia malayi Glycosyl hydrolases family 38 protein 0.0095 0.007 0.007
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0396 0.0392 0.0579
Onchocerca volvulus 0.0134 0.0111 0.0119
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0051 0.0022 0.0019
Trichomonas vaginalis beta-galactosidase, putative 0.0752 0.0774 0.1149
Brugia malayi intermediate filament protein 0.0056 0.0028 0.0028
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0467 0.0468 0.0517
Trichomonas vaginalis mannosyl-oligosaccharide alpha-1,2-mannosidase, putative 0.0101 0.0076 0.0107
Brugia malayi Alpha-L-fucosidase family protein 0.5282 0.563 0.563
Schistosoma mansoni alpha-glucosidase 0.8453 0.9029 1
Brugia malayi Glycosyl hydrolases family 2, sugar binding domain containing protein 0.0302 0.0291 0.0291
Mycobacterium ulcerans glycogen phosphorylase GlgP 0.0144 0.0122 0.0167
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0051 0.0022 0.0019
Echinococcus multilocularis musashi 0.0056 0.0028 0.0026
Schistosoma mansoni beta-galactosidase 0.1299 0.1361 0.1505
Echinococcus granulosus beta D xylosidase 2 0.0034 0.0004 0.0002
Echinococcus multilocularis fucosidase, alpha L 1, tissue 0.6668 0.7117 0.7116
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0131 0.0108 0.0106
Echinococcus granulosus lamin dm0 0.0056 0.0028 0.0026
Trichomonas vaginalis alpha-glucosidase, putative 0.1062 0.1106 0.1645
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0046 0.0017 0.0017
Echinococcus granulosus bile acid beta glucosidase 0.108 0.1126 0.1124
Trichomonas vaginalis alpha-glucosidase, putative 0.1062 0.1106 0.1645
Schistosoma mansoni alpha glucosidase 0.2137 0.2259 0.2501
Loa Loa (eye worm) hypothetical protein 0.0101 0.0076 0.0076
Trichomonas vaginalis mannosyl-oligosaccharide alpha-1,2-mannosidase, putative 0.0101 0.0076 0.0107
Schistosoma mansoni lysosomal alpha-mannosidase (mannosidase alpha class 2b member 1) 0.0095 0.007 0.0075
Trichomonas vaginalis sucrase-isomaltase, putative 0.1968 0.2077 0.3094
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0039 0.0041
Trichomonas vaginalis beta-mannosidase, putative 0.0249 0.0235 0.0344
Echinococcus multilocularis transfer RNA-Trp 0.0101 0.0076 0.0074
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0118 0.0095 0.0833
Trichomonas vaginalis alpha-glucosidase, putative 0.2137 0.2259 0.3366
Echinococcus granulosus lamin 0.0056 0.0028 0.0026
Loa Loa (eye worm) hypothetical protein 0.1299 0.1361 0.1361
Trichomonas vaginalis conserved hypothetical protein 0.0752 0.0774 0.1149
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.1062 0.1106 0.1645
Toxoplasma gondii melibiase subfamily protein 0.0467 0.0468 0.201
Entamoeba histolytica glycogen phosphorylase, putative 0.0334 0.0326 0.1427
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0107 0.0082 0.0695
Schistosoma mansoni ceramide glucosyltransferase 0.1476 0.155 0.1715
Trypanosoma cruzi lysosomal alpha-mannosidase precursor, putative 0.0134 0.0112 0.0419

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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