Detailed information for compound 181006

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 344.403 | Formula: C23H20O3
  • H donors: 2 H acceptors: 3 LogP: 6.03 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1cccc2c1C(=O)c1c(C2CCCc2ccccc2)cccc1O
  • InChi: 1S/C23H20O3/c24-19-13-5-11-17-16(10-4-9-15-7-2-1-3-8-15)18-12-6-14-20(25)22(18)23(26)21(17)19/h1-3,5-8,11-14,16,24-25H,4,9-10H2
  • InChiKey: XRTZAPCKGUMDPU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0011 0.0104 0.34
Schistosoma mansoni hypothetical protein 0.0011 0.0104 0.0121
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0009 0.0042
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.006 0.006
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0011 0.0104 0.2715
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0193 0.0894
Toxoplasma gondii sugar transporter ST3 0.0015 0.0193 0.0304
Echinococcus multilocularis cpg binding protein 0.003 0.0515 0.0515
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0009 0.0042
Loa Loa (eye worm) hypothetical protein 0.0011 0.0101 0.0191
Brugia malayi Sugar transporter family protein 0.0015 0.0193 0.0363
Schistosoma mansoni glucose transport protein 0.0105 0.216 0.2529
Schistosoma mansoni glucose transporter 0.0015 0.0193 0.0226
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0307 0.0577
Onchocerca volvulus 0.0015 0.0193 0.0621
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0011 0.0104 0.34
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.195 0.9027
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0032 0.0558 0.2583
Echinococcus multilocularis neuropeptide s receptor 0.0465 1 1
Schistosoma mansoni nuclear hormone receptor 0.0009 0.0077 0.009
Loa Loa (eye worm) hypothetical protein 0.0011 0.0101 0.0191
Schistosoma mansoni protein kinase 0.0033 0.0579 0.0678
Brugia malayi Cam kinase protein 1 0.0033 0.0579 0.1089
Plasmodium falciparum calcium-dependent protein kinase 3 0.0033 0.0579 0.0604
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0307 0.0577
Brugia malayi lysyl-tRNA synthetase 0.0023 0.0382 0.0719
Brugia malayi ecdysteroid receptor 0.002 0.0307 0.0577
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0193 0.0894
Schistosoma mansoni hypothetical protein 0.0171 0.3593 0.4206
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.025 0.5315 1
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0193 0.0894
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0011 0.0101 0.0191
Brugia malayi major facilitator superfamily protein 0.0015 0.0193 0.0363
Loa Loa (eye worm) hypothetical protein 0.0013 0.0156 0.0294
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0307 0.0359
Loa Loa (eye worm) histone methyltransferase 0.0009 0.006 0.0112
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0382 1
Trypanosoma cruzi cytochrome P450, putative 0.0011 0.0104 0.0532
Schistosoma mansoni nuclear hormone receptor 0.002 0.0307 0.0359
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0307 0.0577
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0015 0.0193 0.0193
Toxoplasma gondii lysine-tRNA ligase 0.0023 0.0382 0.0602
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0105 0.216 0.216
Trypanosoma brucei glucose transporter, putative 0.0033 0.0581 0.298
Loa Loa (eye worm) hypothetical protein 0.002 0.0307 0.0577
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0011 0.0114 0.2978
Trichomonas vaginalis glucose transporter, putative 0.0015 0.0193 0.0894
Echinococcus granulosus geminin 0.0171 0.3583 0.3583
Brugia malayi nuclear hormone receptor 0.002 0.0307 0.0577
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0922 0.427
Leishmania major protein kinase, putative 0.0033 0.0579 0.2968
Plasmodium falciparum calcium-dependent protein kinase 4 0.0033 0.0579 0.0604
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0011 0.0104 0.2715
Loa Loa (eye worm) hypothetical protein 0.0015 0.0193 0.0363
Schistosoma mansoni cytochrome P450 0.0011 0.0104 0.0121
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0011 0.0101 0.0101
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0579 0.0579
Onchocerca volvulus 0.0015 0.0193 0.0621
Schistosoma mansoni sugar transporter 0.0015 0.0193 0.0226
Loa Loa (eye worm) hypothetical protein 0.0015 0.0193 0.0363
Schistosoma mansoni serine/threonine protein kinase 0.0096 0.195 0.2283
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0307 0.0307
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0015 0.0193 0.0201
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0581 0.269
Brugia malayi intermediate filament protein 0.0027 0.0462 0.0869
Trichomonas vaginalis glucose transporter, putative 0.0033 0.0581 0.269
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0009 0.0077 0.0144
Loa Loa (eye worm) hypothetical protein 0.0011 0.0101 0.0191
Echinococcus granulosus General substrate transporter 0.009 0.1838 0.1838
Schistosoma mansoni thyroid hormone receptor 0.002 0.0307 0.0359
Echinococcus granulosus Nuclear hormone receptor HR96 0.0009 0.0077 0.0077
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0009 0.0042
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0307 0.0307
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0581 0.269
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0581 0.298
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0579 0.0579
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0011 0.0104 0.2715
Trypanosoma brucei glucose transporter, putative 0.0033 0.0581 0.298
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.195 0.9027
Loa Loa (eye worm) sugar transporter 0.0015 0.0193 0.0363
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0579 0.0579
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0307 0.0359
Brugia malayi Cytochrome P450 family protein 0.0011 0.0104 0.0195
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0015 0.0193 1
Schistosoma mansoni lamin 0.0027 0.0462 0.0541
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0193 0.0894
Trypanosoma brucei glucose transporter, putative 0.0033 0.0581 0.298
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0193 0.0894
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0307 0.0577
Plasmodium falciparum protein kinase 7 0.0297 0.6345 0.6614
Loa Loa (eye worm) hypothetical protein 0.025 0.5315 1
Leishmania major glucose transporter/membrane transporter D2, putative 0.0033 0.0581 0.298
Loa Loa (eye worm) hypothetical protein 0.0015 0.0193 0.0363
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0015 0.0193 0.0226
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0015 0.0193 0.6328
Brugia malayi Cytochrome P450 family protein 0.0011 0.0104 0.0195
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0581 0.298
Loa Loa (eye worm) nuclear receptor NHR-67 0.0009 0.0077 0.0144
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0307 0.0307
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0011 0.0104 0.34
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0193 0.0894
Brugia malayi nuclear receptor RXR 0.0011 0.0101 0.0191
Brugia malayi nuclear receptor NHR-67 0.0009 0.0077 0.0144
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.002 0.0305 0.5469
Entamoeba histolytica protein kinase, putative 0.0033 0.0579 0.2968
Mycobacterium leprae putative cytochrome p450 0.0011 0.0104 0.186
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0009 0.0077 0.0077
Plasmodium falciparum calcium-dependent protein kinase 1 0.0033 0.0579 0.0604
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0579 0.0579
Trypanosoma brucei glucose transporter, putative 0.0033 0.0581 0.298
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0193 0.0894
Loa Loa (eye worm) hypothetical protein 0.0015 0.0193 0.0363
Entamoeba histolytica serine/threonine protein kinase, putative 0.0096 0.195 1
Trypanosoma cruzi hexose transporter, putative 0.0018 0.0259 0.133
Mycobacterium ulcerans sugar transporter 0.0015 0.0193 0.5052
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0105 0.216 0.216
Echinococcus multilocularis dnaJ subfamily B 0.0398 0.8541 0.8541
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0009 0.0042
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0672 0.3445
Brugia malayi steroid hormone receptor 0.002 0.0307 0.0577
Echinococcus multilocularis GPCR, family 2 0.0079 0.1594 0.1594
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0193 0.0894
Onchocerca volvulus 0.0015 0.0193 0.0621
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0307 0.0577
Schistosoma mansoni coup transcription factor 0.002 0.0307 0.0359
Loa Loa (eye worm) nuclear hormone receptor 0.0009 0.0077 0.0144
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.1843 0.1843
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0011 0.0104 0.2715
Mycobacterium ulcerans integral membrane transport protein 0.0015 0.0193 0.5052
Toxoplasma gondii cytochrome p450 superfamily protein 0.0011 0.0104 0.0164
Schistosoma mansoni serine/threonine protein kinase 0.0033 0.0579 0.0678
Brugia malayi Latrophilin receptor protein 2 0.0079 0.1594 0.2998
Trypanosoma cruzi sugar transporter, putative 0.0015 0.0193 0.099
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0011 0.0104 0.2715
Brugia malayi Sugar transporter family protein 0.0105 0.216 0.4064
Loa Loa (eye worm) hypothetical protein 0.0009 0.0077 0.0144
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0011 0.0104 0.34
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0193 0.0894
Loa Loa (eye worm) cytochrome P450 0.0011 0.0104 0.0195
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0193 0.0894
Loa Loa (eye worm) hypothetical protein 0.0032 0.0558 0.105
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0382 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0307 0.0307
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0193 0.0894
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0011 0.0104 0.0532
Loa Loa (eye worm) hypothetical protein 0.002 0.0307 0.0577
Loa Loa (eye worm) hypothetical protein 0.0015 0.0193 0.0363
Loa Loa (eye worm) hypothetical protein 0.0015 0.0193 0.0363
Mycobacterium leprae Conserved hypothetical protein 0.0011 0.0104 0.186
Loa Loa (eye worm) cytochrome P450 family protein 0.0011 0.0104 0.0195
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.1843 0.2157
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0011 0.0104 0.0532
Onchocerca volvulus 0.0015 0.0193 0.0621
Brugia malayi nuclear receptor NHR-88 0.002 0.0307 0.0577
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.1843 0.2157
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0032 0.0558 0.0558
Loa Loa (eye worm) hypothetical protein 0.002 0.0307 0.0577
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0011 0.0104 0.2715
Schistosoma mansoni glucose transport protein 0.0105 0.216 0.2529
Echinococcus granulosus Nuclear hormone receptor HR96 0.0009 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0015 0.0193 0.0363
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0193 0.0894
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0307 0.0359
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0307 0.0307
Schistosoma mansoni hypothetical protein 0.0105 0.216 0.2529
Loa Loa (eye worm) hypothetical protein 0.0009 0.0077 0.0144
Loa Loa (eye worm) hypothetical protein 0.0015 0.0193 0.0363
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0009 0.0042
Brugia malayi Sugar transporter family protein 0.0015 0.0193 0.0363
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0032 0.0558 0.105
Brugia malayi hypothetical protein 0.0011 0.0101 0.0191
Loa Loa (eye worm) hypothetical protein 0.0009 0.0077 0.0144
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0037 0.0672 0.1059
Brugia malayi latrophilin 2 splice variant baaae 0.0171 0.3593 0.6759
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0672 0.3445
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0156 0.0156
Schistosoma mansoni nuclear receptor 0.0009 0.0077 0.009
Trypanosoma brucei glucose transporter, putative 0.0033 0.0581 0.298
Plasmodium falciparum mitogen-activated protein kinase 2 0.017 0.3577 0.3728
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0188 0.0353
Brugia malayi hypothetical protein 0.0009 0.0077 0.0144
Loa Loa (eye worm) hypothetical protein 0.0009 0.0077 0.0144
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0307 0.0577
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0101 0.0191
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0011 0.0104 0.34
Brugia malayi Nuclear hormone receptor E75 0.0009 0.0077 0.0144
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0193 0.0894
Entamoeba histolytica hypothetical protein 0.0023 0.0382 0.196
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0015 0.0193 0.099
Echinococcus multilocularis 0.0011 0.0104 0.0104
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0307 0.0577
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0581 0.269
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0009 0.0042
Loa Loa (eye worm) hypothetical protein 0.0015 0.0193 0.0363
Brugia malayi major facilitator superfamily protein 0.0015 0.0193 0.0363
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0011 0.0104 0.2715
Plasmodium falciparum protein kinase 6 0.0447 0.9593 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0307 0.0577
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0009 0.0042
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0193 0.0363
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0307 0.0359
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0011 0.0104 0.2715
Echinococcus granulosus synaptic vesicle 2 protein 0.0015 0.0193 0.0193
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0009 0.0042
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0096 0.195 0.3669
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0009 0.0042
Brugia malayi Cytochrome P450 family protein 0.0011 0.0104 0.0195
Loa Loa (eye worm) hypothetical protein 0.002 0.0307 0.0577
Onchocerca volvulus 0.0015 0.0193 0.0621
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0193 0.0894
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0579 0.0579
Loa Loa (eye worm) hypothetical protein 0.0009 0.0077 0.0144
Onchocerca volvulus 0.002 0.0307 0.1228
Brugia malayi tailless protein 0.0009 0.0077 0.0144
Echinococcus multilocularis lamin 0.0027 0.0462 0.0462
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.1843 0.2157
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0011 0.0104 0.34
Loa Loa (eye worm) DR-78 0.0009 0.0077 0.0144
Echinococcus granulosus FTZ F1 alpha 0.002 0.0307 0.0307
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0581 0.298
Brugia malayi conserved hypotetical protein 0.0009 0.0077 0.0144
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.195 0.9027
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0307 0.0577
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0579 0.0579
Loa Loa (eye worm) cytochrome P450 family protein 0.0011 0.0104 0.0195
Loa Loa (eye worm) hypothetical protein 0.002 0.0307 0.0577
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0057 0.0108
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0307 0.0359
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0193 0.0894
Onchocerca volvulus 0.0027 0.0462 0.2056
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0193 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0581 0.269
Echinococcus multilocularis geminin 0.0171 0.3583 0.3583
Echinococcus granulosus GPCR family 2 0.0079 0.1594 0.1594
Plasmodium vivax sugar transporter, putative 0.0015 0.0193 0.0201
Plasmodium vivax hexose transporter 0.0105 0.216 0.2252
Onchocerca volvulus 0.0027 0.0462 0.2056
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0579 0.0579
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.006 0.006
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0009 0.0077 0.009
Brugia malayi hypothetical protein 0.0015 0.0193 0.0363
Schistosoma mansoni zinc finger protein 0.0009 0.0077 0.009
Loa Loa (eye worm) hypothetical protein 0.002 0.0307 0.0577
Loa Loa (eye worm) hypothetical protein 0.0079 0.1594 0.2998
Onchocerca volvulus 0.0015 0.0193 0.0621
Echinococcus granulosus solute carrier family 22 0.0015 0.0193 0.0193
Schistosoma mansoni hypothetical protein 0.0079 0.1594 0.1866
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0193 0.0894
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0009 0.0077 0.0077
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0307 0.0577
Onchocerca volvulus 0.0015 0.0193 0.0621
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0307 0.0307
Trypanosoma cruzi cytochrome P450, putative 0.0011 0.0104 0.0532
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0033 0.0579 0.0604
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0193 0.0894
Schistosoma mansoni glucose transport protein 0.0105 0.216 0.2529
Onchocerca volvulus 0.0015 0.0193 0.0621
Brugia malayi nuclear hormone receptor 0.0009 0.0077 0.0144
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0193 0.0894
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0009 0.0042
Echinococcus multilocularis General substrate transporter 0.009 0.1838 0.1838
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0011 0.0104 0.34
Loa Loa (eye worm) hypothetical protein 0.0032 0.0558 0.105
Onchocerca volvulus 0.0015 0.0193 0.0621
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0009 0.0077 0.0077
Echinococcus granulosus calcium dependent protein kinase 0.003 0.0529 0.0529
Loa Loa (eye worm) hypothetical protein 0.0009 0.0077 0.0144
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0011 0.0104 0.2715
Schistosoma mansoni cpg binding protein 0.0028 0.048 0.0562
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0193 0.0363
Echinococcus granulosus dnaJ subfamily B 0.0398 0.8541 0.8541
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0193 0.0894
Giardia lamblia Sugar-proton symporter 0.0015 0.0193 0.099
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0193 0.0894
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.195 0.9027
Schistosoma mansoni kinase 0.005 0.0949 0.1111
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0193 0.0894
Loa Loa (eye worm) sugar transporter 0.0105 0.216 0.4064
Onchocerca volvulus Putative transporter 0.0015 0.0193 0.0621
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0193 0.0894
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0009 0.0077 0.0077
Chlamydia trachomatis lysine--tRNA ligase 0.0023 0.0382 1
Plasmodium falciparum hexose transporter 0.0105 0.216 0.2252
Loa Loa (eye worm) CYP4Cod1 0.0011 0.0104 0.0195
Onchocerca volvulus 0.0015 0.0193 0.0621
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0193 0.0363
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0581 0.298
Brugia malayi hypothetical protein 0.0009 0.0077 0.0144
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0011 0.0104 0.2715
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0307 0.0359
Echinococcus granulosus lysyl tRNA synthetase 0.0023 0.0382 0.0382
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0011 0.0104 0.34
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0193 0.0894
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0105 0.216 0.216
Toxoplasma gondii sugar transporter ST2 0.0015 0.0193 0.0304
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0011 0.0104 0.2715
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0033 0.0579 0.0913
Onchocerca volvulus 0.0015 0.0193 0.0621
Onchocerca volvulus 0.0015 0.0193 0.0621
Brugia malayi hypothetical protein 0.0011 0.0101 0.0191
Brugia malayi CXXC zinc finger family protein 0.0028 0.048 0.0903
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0032 0.0558 0.105
Loa Loa (eye worm) hypothetical protein 0.0015 0.0193 0.0363
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0011 0.0104 0.34
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0032 0.0558 0.2861
Brugia malayi Nuclear hormone receptor E75 0.0009 0.0077 0.0144
Loa Loa (eye worm) hypothetical protein 0.0015 0.0193 0.0363
Loa Loa (eye worm) hypothetical protein 0.0009 0.0077 0.0144
Echinococcus multilocularis solute carrier family 22 0.0015 0.0193 0.0193
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0307 0.0577
Brugia malayi hypothetical protein 0.0015 0.0193 0.0363
Plasmodium vivax proline--tRNA ligase, putative 0.0037 0.0672 0.07
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0079 0.1594 0.1594
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.1025 0.1615
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0101 0.0191
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0307 0.0307
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0009 0.0042
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0011 0.0101 0.0119
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0011 0.0104 0.0532
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0009 0.0042
Echinococcus multilocularis solute carrier family 22 0.0015 0.0193 0.0193
Schistosoma mansoni hypothetical protein 0.0171 0.3583 0.4195
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0009 0.0042
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.1843 0.1843
Plasmodium falciparum calcium-dependent protein kinase 5 0.0033 0.0579 0.0604
Echinococcus granulosus solute carrier family 22 0.0015 0.0193 0.0193
Echinococcus multilocularis solute carrier family 22 0.0015 0.0193 0.0193
Trypanosoma brucei glucose transporter 2A 0.0033 0.0581 0.298
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0032 0.0558 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0022 0.0022
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0021 0.0319 0.1477
Onchocerca volvulus 0.0028 0.048 0.2153
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0033 0.0579 0.1089
Loa Loa (eye worm) hypothetical protein 0.0171 0.3593 0.6759
Echinococcus granulosus solute carrier family 22 0.0015 0.0193 0.0193
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0193 0.0894
Chlamydia trachomatis proline--tRNA ligase 0.0011 0.0114 0.2978
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0011 0.0104 0.34
Echinococcus granulosus thyroid hormone receptor alpha 0.0009 0.0077 0.0077
Schistosoma mansoni hypothetical protein 0.0398 0.8541 1
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0193 0.0894
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0022 0.0022
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0096 0.195 1
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0096 0.195 0.195
Schistosoma mansoni sugar transporter 0.0015 0.0193 0.0226
Loa Loa (eye worm) hypothetical protein 0.0013 0.0145 0.0274
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0307 0.0577
Trichomonas vaginalis helicase, putative 0.0006 0.0009 0.0042
Loa Loa (eye worm) hypothetical protein 0.0013 0.0145 0.0274
Toxoplasma gondii sugar transporter ST1 0.0015 0.0193 0.0304
Loa Loa (eye worm) hypothetical protein 0.0015 0.0193 0.0363
Leishmania major lysyl-tRNA synthetase, putative 0.0023 0.0382 0.196
Echinococcus multilocularis neuropeptide receptor A26 0.0465 1 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.1843 0.1843
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0011 0.0104 0.34
Brugia malayi Cytochrome P450 family protein 0.003 0.0522 0.0981
Schistosoma mansoni sugar transporter 0.0015 0.0193 0.0226
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0307 0.1228
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0091 0.1843 0.3467
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0193 0.0894
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0307 0.0307
Leishmania major hypothetical protein, conserved 0.0015 0.0193 0.099
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0193 0.0894
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0307 0.0577
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0193 0.0363
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0037 0.0672 0.3445
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0382 0.0447
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0033 0.0579 0.1089
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0922 0.427
Schistosoma mansoni hypothetical protein 0.0171 0.3583 0.4195
Plasmodium vivax calcium-dependent protein kinase, putative 0.0033 0.0579 0.0604
Loa Loa (eye worm) latrophilin receptor protein 2 0.0079 0.1594 0.2998
Schistosoma mansoni intermediate filament proteins 0.0027 0.0462 0.0541
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0105 0.216 0.216
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0193 0.0894
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0079 0.1594 0.1594
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0462 0.0869
Trypanosoma brucei glucose transporter, putative 0.0033 0.0581 0.298
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0462 0.0869
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0581 0.298
Toxoplasma gondii facilitative glucose transporter GT1 0.0105 0.216 0.3405
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0307 0.0577
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0022 0.0022
Plasmodium vivax CDK-related protein kinase 6, putative 0.0447 0.9593 1
Onchocerca volvulus 0.0015 0.0193 0.0621
Treponema pallidum prolyl-tRNA synthetase 0.0011 0.0114 1
Trypanosoma brucei glucose transporter, putative 0.0033 0.0581 0.298
Schistosoma mansoni cpg binding protein 0.003 0.0515 0.0603
Echinococcus granulosus lamin dm0 0.0027 0.0462 0.0462
Plasmodium vivax lysine--tRNA ligase, putative 0.0023 0.0382 0.0398
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0011 0.0104 0.34
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0033 0.0579 0.0913
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0193 0.0363
Loa Loa (eye worm) hypothetical protein 0.0009 0.0077 0.0144
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0079 0.1594 0.2998
Loa Loa (eye worm) hypothetical protein 0.0023 0.0382 0.0719
Loa Loa (eye worm) pigment dispersing factor receptor c 0.025 0.5315 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0079 0.1594 0.1594
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.048 0.0903
Loa Loa (eye worm) hypothetical protein 0.0009 0.0077 0.0144
Loa Loa (eye worm) cytochrome P450 family protein 0.003 0.0522 0.0981
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0033 0.0579 0.2968
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.002 0.0305 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0193 0.0363
Echinococcus multilocularis lysyl tRNA synthetase 0.0023 0.0382 0.0382
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0011 0.0104 0.2715
Echinococcus multilocularis lamin dm0 0.0027 0.0462 0.0462
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0462 0.0869
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0011 0.0104 0.0532
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0032 0.0558 0.0558
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0009 0.0077 0.0077
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.195 0.9027
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0011 0.0104 0.2715
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0105 0.216 0.216
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0307 0.0307
Echinococcus granulosus neuropeptide receptor A26 0.0465 1 1
Schistosoma mansoni thyroid hormone receptor 0.002 0.0307 0.0359
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0011 0.0104 0.2715
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0011 0.0104 0.0532
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0022 0.0026
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0032 0.0558 0.0653
Loa Loa (eye worm) hypothetical protein 0.0027 0.0462 0.0869
Giardia lamblia Prolyl-tRNA synthetase 0.0032 0.0558 0.2861
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0105 0.216 0.216
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0307 0.0577
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0013 0.0153 0.0288
Brugia malayi ecdysone receptor 0.0009 0.0077 0.0144
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0011 0.0104 0.2715
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0011 0.0104 0.2715
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0307 0.0577
Trypanosoma brucei cytochrome P450, putative 0.0011 0.0104 0.0532
Trichomonas vaginalis sugar transport protein, putative 0.0015 0.0193 0.0894
Trypanosoma brucei glucose transporter, putative 0.0033 0.0581 0.298
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0307 0.0577
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0307 0.0577
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0009 0.0077 0.0144
Trichomonas vaginalis glucose transporter, putative 0.0033 0.0581 0.269
Brugia malayi serine/threonine-protein kinase plk-2 0.0096 0.195 0.3669
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0009 0.0042
Toxoplasma gondii protein kinase, putative 0.0297 0.6345 1
Brugia malayi orphan nuclear receptor NR2E1 0.0009 0.0077 0.0144
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.195 0.9027
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0011 0.0104 0.2715
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0011 0.0104 0.2715
Schistosoma mansoni nuclear receptor 0.0009 0.0077 0.009
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0011 0.0104 0.2715
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0011 0.0104 0.2715
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0307 0.0577
Echinococcus granulosus lamin 0.0027 0.0462 0.0462
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.017 0.3577 0.5637
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0382 0.0447
Plasmodium falciparum lysine--tRNA ligase 0.0023 0.0382 0.0398
Loa Loa (eye worm) hypothetical protein 0.0015 0.0193 0.0363
Loa Loa (eye worm) hypothetical protein 0.0033 0.0579 0.1089
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0307 0.1228
Loa Loa (eye worm) hypothetical protein 0.0009 0.0077 0.0144
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0009 0.0077 0.0077
Brugia malayi nuclear receptor RXR 0.0009 0.0077 0.0144
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0009 0.0042
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0033 0.0579 0.0604
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0193 0.0894
Leishmania major glucose transporter, lmgt3 0.0033 0.0581 0.298
Trypanosoma cruzi polo-like protein kinase, putative 0.0096 0.195 1
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0193 0.0894
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0033 0.0579 0.0604
Trypanosoma cruzi hexose transporter, putative 0.0015 0.0193 0.099
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0011 0.0104 0.34
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0581 0.269
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0011 0.0104 0.34
Schistosoma mansoni hypothetical protein 0.0079 0.1594 0.1866
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0079 0.1594 0.1594
Toxoplasma gondii transporter, major facilitator family protein 0.0015 0.0193 0.0304
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0105 0.216 0.216
Leishmania major cytochrome p450-like protein 0.0011 0.0104 0.0532
Trypanosoma cruzi glucose transporter, putative 0.0015 0.0193 0.099
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0033 0.0579 0.0579
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0307 0.0307
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0193 0.0894
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0188 0.0353
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0023 0.0382 0.6849
Brugia malayi cytochrome P450 0.0011 0.0104 0.0195
Loa Loa (eye worm) hypothetical protein 0.0027 0.0451 0.0849
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0193 0.0894
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0009 0.0077 0.0077
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0096 0.195 0.195
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0101 0.0119
Echinococcus multilocularis musashi 0.0027 0.0462 0.0462
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0011 0.0101 0.0101
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0193 0.0894
Schistosoma mansoni sugar transporter 0.0015 0.0193 0.0226
Schistosoma mansoni hypothetical protein 0.0079 0.1594 0.1866
Trypanosoma brucei polo-like protein kinase 0.0096 0.195 1
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0009 0.0077 0.009
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0022 0.0022
Echinococcus multilocularis synaptic vesicle 2 protein 0.0015 0.0193 0.0193
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0033 0.0579 0.0913
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0011 0.0104 0.34
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0011 0.0104 0.34
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0011 0.0104 0.34
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0011 0.0104 0.34
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0105 0.216 0.216
Trichomonas vaginalis CAMK family protein kinase 0.0033 0.0579 0.2679
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0009 0.0042
Echinococcus multilocularis nuclear receptor nhr 48 0.0009 0.0077 0.0077
Schistosoma mansoni nuclear receptor nhr-48 0.0009 0.0077 0.009
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0037 0.0672 0.3445
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0307 0.0577
Echinococcus granulosus solute carrier family 22 0.0015 0.0193 0.0193
Onchocerca volvulus 0.0015 0.0193 0.0621
Loa Loa (eye worm) hypothetical protein 0.0011 0.0101 0.0191
Schistosoma mansoni protein kinase 0.0033 0.0579 0.0678
Brugia malayi nuclear hormone receptor family member nhr-6 0.0009 0.0077 0.0144
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0307 0.0307
Schistosoma mansoni lamin 0.0027 0.0462 0.0541
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0581 0.298
Brugia malayi Calcitonin receptor-like protein seb-1 0.025 0.5315 1
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0011 0.0104 0.34
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0307 0.0359
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.1162 0.1361
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0307 0.0577
Onchocerca volvulus 0.0015 0.0193 0.0621
Loa Loa (eye worm) hypothetical protein 0.0009 0.0077 0.0144
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0015 0.0193 0.5052
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0307 0.0577
Loa Loa (eye worm) hypothetical protein 0.0009 0.0077 0.0144
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0011 0.0104 0.2715
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0382 0.1769
Leishmania major cytochrome p450-like protein 0.0011 0.0104 0.0532
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0023 0.0382 0.196
Onchocerca volvulus 0.0015 0.0193 0.0621
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0307 0.0359
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0307 0.0577
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0009 0.0042
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0193 0.0894
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.017 0.3577 0.3728
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0307 0.0307
Brugia malayi nuclear hormone receptor family member odr-7 0.0009 0.0077 0.0144
Echinococcus multilocularis solute carrier family 22 0.0015 0.0193 0.0193
Schistosoma mansoni nuclear hormone receptor 0.0009 0.0077 0.009
Leishmania major glucose transporter, lmgt2 0.0033 0.0581 0.298
Trypanosoma cruzi polo-like protein kinase, putative 0.0096 0.195 1
Trichomonas vaginalis conserved hypothetical protein 0.0105 0.216 1
Trypanosoma brucei sugar transporter, putative 0.0015 0.0193 0.099
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0193 0.0894
Giardia lamblia Hexose transporter 0.0015 0.0193 0.099
Loa Loa (eye worm) hypothetical protein 0.0015 0.0193 0.0363
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0015 0.0193 0.5052
Schistosoma mansoni cpg binding protein 0.003 0.0515 0.0603
Entamoeba histolytica protein kinase, putative 0.0033 0.0579 0.2968
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0193 0.0894
Brugia malayi hypothetical protein 0.0015 0.0193 0.0363
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0193 0.0894
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0307 0.0307
Loa Loa (eye worm) hypothetical protein 0.0026 0.0429 0.0807
Trypanosoma brucei glucose transporter 1E 0.0033 0.0581 0.298
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0023 0.0382 0.196
Schistosoma mansoni protein kinase 0.0033 0.0579 0.0678
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.002 0.0305 1
Plasmodium falciparum calcium-dependent protein kinase 2 0.0033 0.0579 0.0604
Echinococcus granulosus Sugar transporter ERD6 protein 0.0015 0.0193 0.0193
Brugia malayi nuclear receptor NHR-88 0.0009 0.0077 0.0144
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0307 0.0359
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0015 0.0193 0.6328
Plasmodium falciparum proline--tRNA ligase 0.0037 0.0672 0.07
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.1843 0.1843
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0307 0.0307
Echinococcus granulosus nuclear receptor nhr 48 0.0009 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0009 0.0077 0.0144
Giardia lamblia Kinase, PLK 0.0096 0.195 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0307 0.0577
Schistosoma mansoni hypothetical protein 0.0079 0.1594 0.1866
Trichomonas vaginalis myo-inositol transporter, putative 0.0015 0.0193 0.0894
Echinococcus granulosus intermediate filament protein 0.0027 0.0462 0.0462
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0307 0.0307
Loa Loa (eye worm) hypothetical protein 0.002 0.0307 0.0577
Echinococcus multilocularis calcium dependent protein kinase 0.003 0.0529 0.0529
Leishmania major myo-inositol/proton symporter (MIT) 0.0015 0.0193 0.099
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0307 0.1228
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0091 0.1843 0.3467
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0307 0.0307
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0672 0.3445
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0033 0.0579 0.1089
Leishmania major glucose transporter, lmgt1 0.0033 0.0581 0.298
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0307 0.0307
Echinococcus granulosus cytochrome P450 2K1 0.0011 0.0104 0.0104
Echinococcus granulosus cpg binding protein 0.003 0.0515 0.0515
Giardia lamblia Lysyl-tRNA synthetase 0.0023 0.0382 0.196
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0193 0.0894
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0032 0.0558 0.0653
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0156 0.0156
Onchocerca volvulus Serine\/threonine kinase homolog 0.0096 0.195 1
Trypanosoma cruzi hexose transporter 0.0033 0.0581 0.298
Loa Loa (eye worm) hypothetical protein 0.002 0.0307 0.0577
Loa Loa (eye worm) hypothetical protein 0.0011 0.0101 0.0191
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0193 0.0894
Leishmania major cytochrome p450-like protein 0.0011 0.0104 0.0532
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.195 0.9027
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0011 0.0104 0.34

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) < 0.2 uM of MDA (mM of deoxyribose)-1 Deoxyribose degradation as a measure of hydroxyl-radical generation. ChEMBL. 9873705
IC50 (functional) > 5 uM In vitro for antiproliferate activity against HaCaT cells ChEMBL. 9873705
LDH (functional) = 130 MU Compound was measured for lactate dehydrogenase(LDH) release in HaCaT cells after treatment with 2 uM ChEMBL. 9873705
logP (ADMET) = 5.51 Partition coefficient (logP) ChEMBL. 9873705

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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