Detailed information for compound 1822670

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 821.906 | Formula: C44H55NO14
  • H donors: 5 H acceptors: 9 LogP: 3.25 Rotable bonds: 15
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C(N[C@H]([C@H](C(=O)O[C@H]1C[C@@]2(O)[C@@H](OC(=O)c3ccccc3)[C@@H]3[C@@]4(CO[C@@H]4C[C@@H]([C@]3(C(=O)[C@@H](C(=C1C)C2(C)C)O)C)O)OC(=O)C)O)c1ccccc1)O[C@H](C(C)C)C
  • InChi: 1S/C44H55NO14/c1-22(2)24(4)56-40(53)45-32(26-15-11-9-12-16-26)34(49)39(52)57-28-20-44(54)37(58-38(51)27-17-13-10-14-18-27)35-42(8,36(50)33(48)31(23(28)3)41(44,6)7)29(47)19-30-43(35,21-55-30)59-25(5)46/h9-18,22,24,28-30,32-35,37,47-49,54H,19-21H2,1-8H3,(H,45,53)/t24-,28-,29-,30+,32-,33+,34+,35-,37-,42+,43-,44+/m0/s1
  • InChiKey: SEHFNYYJZGUCSW-GDQWOZPYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi isocitrate dehydrogenase 0.0018 0.0018 0.0014
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0654 0.362 0.3617
Echinococcus multilocularis cpg binding protein 0.0099 0.0476 0.0472
Trichomonas vaginalis tubulin beta chain, putative 0.0064 0.0278 0.0825
Echinococcus multilocularis tubulin alpha chain 0.0064 0.0278 0.0274
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0559 0.3078 0.3075
Schistosoma mansoni tubulin subunit epsilon 0.0055 0.0227 0.0223
Trichomonas vaginalis tubulin epsilon chain, putative 0.0064 0.0278 0.0825
Plasmodium falciparum alpha tubulin 1 0.0064 0.0278 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0654 0.362 0.3617
Echinococcus multilocularis cyclin B3 1 0.0019 0.0026 0.0022
Trichomonas vaginalis CMGC family protein kinase 0.0559 0.3078 1
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0028 0.0078 0.0074
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0037 0.0034
Echinococcus granulosus tubulin alpha 3 chain 0.0064 0.0278 0.0274
Echinococcus granulosus Tubulin beta 2C chain 0.0055 0.0227 0.0223
Onchocerca volvulus Protein ultraspiracle homolog 0.0033 0.0102 0.027
Schistosoma mansoni serine/threonine protein kinase 0.0016 0.0006 0.0002
Leishmania major alpha tubulin 0.0064 0.0278 0.085
Loa Loa (eye worm) hypothetical protein 0.0046 0.0179 0.0175
Brugia malayi Isocitrate dehydrogenase 0.0018 0.0018 0.0014
Entamoeba histolytica tubulin family protein 0.0055 0.0227 0.6224
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0559 0.3078 1
Trichomonas vaginalis tubulin beta chain, putative 0.0064 0.0278 0.0825
Echinococcus granulosus mitogen activated protein kinase 0.0559 0.3078 0.3075
Entamoeba histolytica cell division protein kinase 2, putative 0.0054 0.0222 0.6059
Schistosoma mansoni coup transcription factor 0.0033 0.0102 0.0098
Echinococcus multilocularis beta tubulin 0.0055 0.0227 0.0223
Giardia lamblia Alpha-tubulin 0.0064 0.0278 0.0825
Plasmodium falciparum tubulin gamma chain 0.0055 0.0227 0.8051
Schistosoma mansoni tubulin subunit beta 0.0055 0.0227 0.0223
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0033 0.0102 0.0098
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0055 0.0227 0.0223
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0018 0.0018 0.0014
Echinococcus multilocularis tubulin alpha 1C chain 0.0064 0.0278 0.0274
Leishmania major alpha tubulin 0.0064 0.0278 0.085
Toxoplasma gondii LsmAD domain-containing protein 0.0055 0.0226 0.0735
Trypanosoma cruzi cyclin 6, putative 0.0046 0.0179 0.0527
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0037 0.0034
Echinococcus granulosus tubulin gamma 1 chain 0.0055 0.0227 0.0223
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0116 0.0319
Trypanosoma brucei epsilon tubulin 0.0055 0.0227 0.0685
Echinococcus granulosus dnaJ subfamily B 0.0869 0.4833 0.483
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0116 0.0293
Echinococcus granulosus beta tubulin 0.0055 0.0227 0.0223
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0559 0.3078 1
Echinococcus multilocularis Tubulin beta 2C chain 0.0055 0.0227 0.0223
Echinococcus multilocularis peroxisome assembly protein 26 0.0064 0.0278 0.0274
Echinococcus multilocularis cyclin b3 0.0019 0.0026 0.0022
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.0116 0.0112
Giardia lamblia Beta tubulin 0.0055 0.0227 0.0659
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0149 0.0759 0.0755
Trypanosoma cruzi epsilon tubulin, putative 0.0055 0.0227 0.0685
Echinococcus multilocularis cyclin dependent kinase 1 0.0054 0.0222 0.0218
Trichomonas vaginalis CMGC family protein kinase 0.0559 0.3078 1
Echinococcus granulosus tubulin epsilon chain 0.0055 0.0227 0.0223
Echinococcus granulosus mixed lineage leukemia protein mll 0.0023 0.0048 0.0044
Trichomonas vaginalis glucosylceramidase, putative 0.0274 0.1469 0.4727
Onchocerca volvulus 0.0654 0.362 1
Onchocerca volvulus 0.0093 0.0446 0.1221
Trichomonas vaginalis tubulin alpha chain, putative 0.0031 0.0093 0.0217
Echinococcus granulosus Tubulin alpha 1 chain 0.0064 0.0278 0.0274
Echinococcus multilocularis dnaJ subfamily B 0.0869 0.4833 0.483
Echinococcus multilocularis enteropeptidase 0.0654 0.362 0.3617
Trichomonas vaginalis tubulin beta chain, putative 0.0064 0.0278 0.0825
Echinococcus multilocularis geminin 0.0367 0.1995 0.1992
Schistosoma mansoni serine/threonine protein kinase 0.0016 0.0006 0.0002
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.005 0.0197 0.0193
Echinococcus granulosus lamin 0.0059 0.0251 0.0247
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0149 0.0759 0.0755
Onchocerca volvulus 0.0654 0.362 1
Schistosoma mansoni hypothetical protein 0.0367 0.1995 0.1992
Trypanosoma brucei tubulin gamma chain 0.0055 0.0227 0.0685
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0037 0.0034
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0018 0.0014
Brugia malayi photoreceptor-specific nuclear receptor 0.0033 0.0102 0.0098
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0076 0.0349 0.0345
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0222 0.0642
Echinococcus multilocularis lamin 0.0059 0.0251 0.0247
Echinococcus granulosus beta tubulin 0.0055 0.0227 0.0223
Schistosoma mansoni cercarial elastase (S01 family) 0.0654 0.362 0.3617
Leishmania major beta tubulin 0.0055 0.0227 0.0685
Trichomonas vaginalis tubulin beta chain, putative 0.0064 0.0278 0.0825
Loa Loa (eye worm) BEN-1 protein 0.0055 0.0227 0.0223
Brugia malayi Trypsin family protein 0.0654 0.362 0.3617
Loa Loa (eye worm) tubulin beta-1 chain 0.0055 0.0227 0.0223
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0037 0.0034
Trichomonas vaginalis tubulin, putative 0.0031 0.0093 0.0217
Loa Loa (eye worm) hypothetical protein 0.013 0.0653 0.0649
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0033 0.0102 0.0098
Trichomonas vaginalis tubulin epsilon chain, putative 0.0064 0.0278 0.0825
Onchocerca volvulus 0.0654 0.362 1
Loa Loa (eye worm) tubulin alpha chain 0.0064 0.0278 0.0274
Echinococcus multilocularis Tubulin beta 2C chain 0.0055 0.0227 0.0223
Brugia malayi Tubulin alpha-2 chain 0.0064 0.0278 0.0274
Schistosoma mansoni cercarial elastase (S01 family) 0.0654 0.362 0.3617
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0559 0.3078 1
Brugia malayi tubulin alpha-2 chain 0.0064 0.0278 0.0274
Onchocerca volvulus Bile acid receptor homolog 0.0033 0.0102 0.027
Loa Loa (eye worm) hypothetical protein 0.0033 0.0102 0.0098
Brugia malayi Cyclin, N-terminal domain containing protein 0.0019 0.0026 0.0022
Echinococcus multilocularis hypothetical protein 0.0064 0.0278 0.0274
Loa Loa (eye worm) beta-tubulin 0.0055 0.0227 0.0223
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0149 0.0759 0.0755
Echinococcus multilocularis tubulin alpha chain 0.0064 0.0278 0.0274
Leishmania major gamma-tubulin 0.0055 0.0227 0.0685
Brugia malayi Latrophilin receptor protein 2 0.005 0.0197 0.0193
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0015 0.001
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.005 0.0197 0.0193
Loa Loa (eye worm) hypothetical protein 0.0059 0.0251 0.0247
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0654 0.362 0.3617
Echinococcus granulosus FTZ F1 alpha 0.0033 0.0102 0.0098
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0033 0.0102 0.0098
Leishmania major beta tubulin 0.0055 0.0227 0.0685
Toxoplasma gondii histone lysine methyltransferase SET1 0.0177 0.0918 0.2983
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0037 0.0034
Echinococcus granulosus tubulin alpha 1C chain 0.0064 0.0278 0.0274
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0033 0.0102 0.0098
Echinococcus granulosus tubulin alpha chain 0.0064 0.0278 0.0274
Echinococcus multilocularis cyclins 0.0019 0.0026 0.0022
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.005 0.0197 0.0193
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0033 0.0103 0.025
Schistosoma mansoni hypothetical protein 0.005 0.0197 0.0193
Trypanosoma brucei alpha tubulin 0.0064 0.0278 0.085
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0654 0.362 0.3617
Echinococcus granulosus transmembrane protease serine 3 0.0654 0.362 0.3617
Trichomonas vaginalis cyclins, putative 0.0046 0.0179 0.0501
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.0935 0.2978
Trypanosoma cruzi CYC2-like cyclin, putative 0.0046 0.0179 0.0527
Brugia malayi Tubulin alpha chain 0.0024 0.0052 0.0048
Treponema pallidum cell division protein FtsZ 0.0024 0.0052 0.5
Echinococcus granulosus lamin dm0 0.0059 0.0251 0.0247
Echinococcus granulosus enteropeptidase 0.0654 0.362 0.3617
Echinococcus granulosus alpha tubulin 0.0064 0.0278 0.0274
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0116 0.2766
Trypanosoma cruzi zeta tubulin, putative 0.0024 0.0052 0.0111
Schistosoma mansoni hypothetical protein 0.1782 1 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0032 0.0096 0.0092
Echinococcus multilocularis transmembrane protease serine 3 0.0654 0.362 0.3617
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0019 0.0026 0.0022
Trichomonas vaginalis CMGC family protein kinase 0.0559 0.3078 1
Schistosoma mansoni glutaminase 0.0265 0.1419 0.1415
Loa Loa (eye worm) hypothetical protein 0.005 0.0197 0.0193
Brugia malayi Cyclin, N-terminal domain containing protein 0.0046 0.0179 0.0175
Echinococcus granulosus tubulin alpha chain 0.0064 0.0278 0.0274
Brugia malayi beta-tubulin, identical 0.0055 0.0227 0.0223
Schistosoma mansoni alpha tubulin 0.0064 0.0278 0.0274
Echinococcus granulosus tubulin alpha chain 0.0064 0.0278 0.0274
Trypanosoma cruzi cdc2-related kinase 1 0.0054 0.0222 0.0667
Schistosoma mansoni hypothetical protein 0.0869 0.4833 0.483
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0198 0.1038 0.1034
Schistosoma mansoni protein kinase C mu 0.0016 0.0006 0.0002
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0033 0.0102 0.0098
Trichomonas vaginalis cyclin B, putative 0.0046 0.0179 0.0501
Trichomonas vaginalis tubulin, putative 0.0055 0.0227 0.0659
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0024 0.0052 0.0169
Trypanosoma brucei epsilon tubulin 0.0055 0.0227 0.0685
Plasmodium falciparum protein kinase 5 0.0054 0.0222 0.7846
Schistosoma mansoni serine/threonine protein kinase 0.0016 0.0006 0.0002
Schistosoma mansoni cercarial elastase (S01 family) 0.0654 0.362 0.3617
Loa Loa (eye worm) hypothetical protein 0.0107 0.0522 0.0518
Trypanosoma cruzi cyclin, putative 0.0046 0.0179 0.0527
Echinococcus multilocularis mitogen activated protein kinase 3 0.0559 0.3078 0.3075
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0033 0.0102 0.0098
Brugia malayi alpha-tubulin 0.0064 0.0278 0.0274
Trichomonas vaginalis tubulin epsilon chain, putative 0.0055 0.0227 0.0659
Onchocerca volvulus 0.0654 0.362 1
Echinococcus granulosus tubulin alpha 1C chain 0.0064 0.0278 0.0274
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0037 0.0034
Schistosoma mansoni tubulin subunit gamma 0.0055 0.0227 0.0223
Brugia malayi hypothetical protein 0.0654 0.362 0.3617
Trichomonas vaginalis cyclins, putative 0.0032 0.0096 0.0229
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0019 0.0026 0.0022
Echinococcus granulosus Tubulin beta 2C chain 0.0055 0.0227 0.0223
Toxoplasma gondii beta-tubulin, putative 0.0055 0.0227 0.0739
Brugia malayi C1-like domain containing protein 0.0016 0.0006 0.0002
Trypanosoma cruzi PAB1-binding protein , putative 0.0055 0.0226 0.0681
Loa Loa (eye worm) latrophilin receptor protein 2 0.005 0.0197 0.0193
Onchocerca volvulus 0.0031 0.0093 0.0245
Giardia lamblia Kinase, CMGC CDK 0.0054 0.0222 0.0642
Schistosoma mansoni cpg binding protein 0.0099 0.0476 0.0472
Brugia malayi Calcitonin receptor-like protein seb-1 0.0156 0.0802 0.0799
Echinococcus granulosus Mastin 0.0654 0.362 0.3617
Echinococcus granulosus protein kinase c iota type 0.0016 0.0006 0.0002
Brugia malayi cytoplasmic intermediate filament protein 0.0032 0.0096 0.0092
Loa Loa (eye worm) hypothetical protein 0.0017 0.0015 0.001
Plasmodium falciparum tubulin delta chain, putative 0.0024 0.0052 0.1303
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0023 0.0048 0.0044
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0033 0.0102 0.0098
Loa Loa (eye worm) hypothetical protein 0.0017 0.0015 0.001
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0033 0.0102 0.0098
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0116 0.0293
Leishmania major beta tubulin 0.0055 0.0227 0.0685
Echinococcus granulosus cyclins 0.0019 0.0026 0.0022
Loa Loa (eye worm) cyclin domain-containing protein 0.0019 0.0026 0.0022
Loa Loa (eye worm) hypothetical protein 0.004 0.0143 0.0139
Mycobacterium ulcerans glutaminase 0.0265 0.1419 0.3832
Brugia malayi cell division control protein 2 homolog 0.0054 0.0222 0.0218
Echinococcus multilocularis ecdysone induced protein 78C 0.0033 0.0102 0.0098
Echinococcus granulosus tubulin beta 4A class IVa 0.0055 0.0227 0.0223
Brugia malayi Tubulin beta-1 chain 0.0055 0.0227 0.0223
Trichomonas vaginalis tubulin gamma chain, putative 0.0024 0.0052 0.0084
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0033 0.0102 0.0098
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0116 0.0293
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0017 0.0015 0.001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0033 0.0102 0.0098
Schistosoma mansoni hypothetical protein 0.0654 0.362 0.3617
Schistosoma mansoni hypothetical protein 0.0025 0.0056 0.0052
Loa Loa (eye worm) tubulin alpha 2 0.004 0.0143 0.0139
Loa Loa (eye worm) tubulin beta-4 chain 0.0055 0.0227 0.0223
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0054 0.0222 0.0218
Schistosoma mansoni cpg binding protein 0.0093 0.0446 0.0442
Trichomonas vaginalis cyclins, putative 0.0046 0.0179 0.0501
Echinococcus multilocularis lamin dm0 0.0059 0.0251 0.0247
Entamoeba histolytica cyclin, putative 0.0046 0.0179 0.4729
Echinococcus granulosus intermediate filament protein 0.0059 0.0251 0.0247
Schistosoma mansoni tubulin subunit beta 0.0055 0.0227 0.0223
Trypanosoma brucei alpha tubulin 0.0064 0.0278 0.085
Schistosoma mansoni hypothetical protein 0.005 0.0197 0.0193
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0037 0.0034
Brugia malayi Protein kinase domain containing protein 0.0016 0.0006 0.0002
Echinococcus multilocularis thyroid hormone receptor alpha 0.0033 0.0102 0.0098
Giardia lamblia G2/mitotic-specific cyclin B 0.0046 0.0179 0.0501
Echinococcus granulosus tubulin alpha chain 0.0064 0.0278 0.0274
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0029 0.0081 0.0076
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0016 0.0006 0.0002
Loa Loa (eye worm) alpha-tubulin 0.0064 0.0278 0.0274
Plasmodium falciparum tubulin beta chain 0.0055 0.0227 0.8051
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0222 0.0642
Leishmania major cyclin 0.0046 0.0179 0.0527
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0149 0.0759 0.0755
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0015 0.001
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.1782 1 1
Trichomonas vaginalis glucosylceramidase, putative 0.0274 0.1469 0.4727
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0654 0.362 0.3617
Echinococcus granulosus cyclin dependent kinase 5 0.0054 0.0222 0.0218
Echinococcus granulosus glycoprotein Antigen 5 0.0654 0.362 0.3617
Brugia malayi Stress-activated protein kinase jnk-1 0.0258 0.1375 0.1372
Schistosoma mansoni alpha-glucosidase 0.0136 0.0688 0.0684
Echinococcus granulosus tubulin alpha 3 chain 0.0064 0.0278 0.0274
Brugia malayi MH2 domain containing protein 0.0127 0.0634 0.0631
Loa Loa (eye worm) hypothetical protein 0.0046 0.018 0.0176
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0033 0.0102 0.0098
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0029 0.0081 0.0076
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0116 0.0319
Entamoeba histolytica hypothetical protein 0.0076 0.0349 1
Brugia malayi Trypsin family protein 0.0654 0.362 0.3617
Plasmodium falciparum ataxin-2 like protein, putative 0.0055 0.0226 0.8005
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0033 0.0102 0.0098
Schistosoma mansoni cpg binding protein 0.0099 0.0476 0.0472
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0654 0.362 0.3617
Loa Loa (eye worm) hypothetical protein 0.0028 0.0078 0.0074
Entamoeba histolytica tubulin alpha chain, putative 0.0064 0.0278 0.7794
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0033 0.0102 0.0098
Echinococcus granulosus tubulin subunit beta 0.0055 0.0227 0.0223
Trypanosoma brucei beta tubulin 0.0055 0.0227 0.0685
Trichomonas vaginalis tubulin beta chain, putative 0.0064 0.0278 0.0825
Trypanosoma cruzi alpha tubulin, putative 0.0064 0.0278 0.085
Brugia malayi Intermediate filament tail domain containing protein 0.0059 0.0251 0.0247
Schistosoma mansoni serine/threonine protein kinase 0.0054 0.0222 0.0218
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0054 0.0222 0.0218
Schistosoma mansoni serine/threonine protein kinase 0.0016 0.0006 0.0002
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.1782 1 1
Leishmania major alpha tubulin 0.0064 0.0278 0.085
Toxoplasma gondii alpha-tubulin I, putative 0.0064 0.0278 0.0904
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.1782 1 1
Schistosoma mansoni lamin 0.0059 0.0251 0.0247
Schistosoma mansoni transcription factor LCR-F1 0.0076 0.0349 0.0345
Schistosoma mansoni alpha glucosidase 0.0035 0.0116 0.0112
Schistosoma mansoni serine/threonine protein kinase 0.0237 0.1257 0.1253
Loa Loa (eye worm) hypothetical protein 0.0017 0.0015 0.001
Plasmodium vivax protein kinase Crk2 0.0054 0.0222 0.7846
Trypanosoma cruzi cyclin, putative 0.0046 0.0179 0.0527
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0033 0.0102 0.0098
Echinococcus granulosus tubulin subunit TubB 0.0064 0.0278 0.0274
Plasmodium falciparum ataxin-2 like protein, putative 0.0055 0.0226 0.8005
Echinococcus multilocularis lysosomal alpha glucosidase 0.0158 0.0812 0.0808
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0017 0.0015 0.001
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0116 0.0293
Trichomonas vaginalis cyclin A, putative 0.0046 0.0179 0.0501
Echinococcus granulosus cyclins 0.0019 0.0026 0.0022
Schistosoma mansoni serine/threonine protein kinase 0.0016 0.0006 0.0002
Trichomonas vaginalis glucosylceramidase, putative 0.019 0.099 0.3158
Echinococcus granulosus peroxisome assembly protein 26 0.0064 0.0278 0.0274
Loa Loa (eye worm) hypothetical protein 0.0027 0.0072 0.0068
Brugia malayi hypothetical protein 0.0076 0.0349 0.0345
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0116 0.0293
Echinococcus multilocularis protein kinase c epsilon type 0.0016 0.0006 0.0002
Trypanosoma cruzi zeta tubulin, putative 0.0024 0.0052 0.0111
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0654 0.362 0.3617
Echinococcus multilocularis tubulin alpha 3 chain 0.0064 0.0278 0.0274
Brugia malayi Tubulin beta chain 0.0031 0.0093 0.0089
Schistosoma mansoni serine/threonine protein kinase 0.0054 0.0222 0.0218
Trichomonas vaginalis cyclins, putative 0.0046 0.0179 0.0501
Onchocerca volvulus 0.0059 0.0251 0.0683
Brugia malayi hypothetical protein 0.0017 0.0015 0.001
Onchocerca volvulus 0.0091 0.0435 0.1191
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0033 0.0102 0.0098
Echinococcus granulosus geminin 0.0367 0.1995 0.1992
Schistosoma mansoni hypothetical protein 0.1782 1 1
Trypanosoma brucei tubulin delta chain 0.0024 0.0052 0.0111
Echinococcus granulosus tubulin delta chain 0.0024 0.0052 0.0048
Trichomonas vaginalis tubulin gamma chain, putative 0.0055 0.0227 0.0659
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0017 0.0015 0.001
Schistosoma mansoni serine/threonine protein kinase 0.0258 0.1375 0.1372
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0116 0.2766
Echinococcus granulosus mitogen activated protein kinase 3 0.0559 0.3078 0.3075
Trichomonas vaginalis tubulin alpha chain, putative 0.0031 0.0093 0.0217
Plasmodium falciparum alpha tubulin 2 0.0064 0.0278 1
Trypanosoma brucei cdc2-related kinase 1 0.0054 0.0222 0.0667
Schistosoma mansoni tubulin subunit alpha 0.0064 0.0278 0.0274
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0258 0.1375 0.1372
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0037 0.0034
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0023 0.0048 0.0044
Echinococcus granulosus cyclin dependent kinase 1 0.0054 0.0222 0.0218
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0024 0.0052 0.0169
Giardia lamblia Kinase, CMGC CDK 0.0054 0.0222 0.0642
Leishmania major alpha tubulin 0.0064 0.0278 0.085
Echinococcus multilocularis cyclins 0.0019 0.0026 0.0022
Schistosoma mansoni cercarial elastase (S01 family) 0.0654 0.362 0.3617
Schistosoma mansoni hypothetical protein 0.1782 1 1
Trichomonas vaginalis glucosylceramidase, putative 0.0274 0.1469 0.4727
Brugia malayi nuclear hormone receptor 0.0033 0.0102 0.0098
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0017 0.0015 0.001
Brugia malayi Tubulin beta chain 0.0024 0.0052 0.0048
Schistosoma mansoni retinoic acid receptor RXR 0.0033 0.0102 0.0098
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0654 0.362 0.3617
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0033 0.0102 0.0098
Brugia malayi hypothetical protein 0.0017 0.0015 0.001
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0024 0.0052 0.0084
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0156 0.0802 0.0799
Entamoeba histolytica tubulin gamma chain 0.0055 0.0227 0.6224
Trichomonas vaginalis cyclins, putative 0.0046 0.0179 0.0501
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0037 0.0034
Trypanosoma cruzi tubulin gamma chain 0.0055 0.0227 0.0685
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0158 0.0812 0.0808
Leishmania major beta tubulin 0.0055 0.0227 0.0685
Schistosoma mansoni cyclin B 0.0046 0.0179 0.0175
Schistosoma mansoni RAR-like nuclear receptor 0.0033 0.0102 0.0098
Mycobacterium leprae cell division protein FtsZ 0.0024 0.0052 0.5
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0033 0.0102 0.0098
Trichomonas vaginalis cyclin B, putative 0.0046 0.0179 0.0501
Echinococcus granulosus microtubule associated protein 2 0.1466 0.821 0.8209
Trypanosoma cruzi beta tubulin, putative 0.0055 0.0227 0.0685
Trypanosoma brucei protein kinase, putative 0.0559 0.3078 1
Echinococcus multilocularis mitogen activated protein kinase 0.0559 0.3078 0.3075
Brugia malayi CXXC zinc finger family protein 0.0093 0.0446 0.0442
Leishmania major beta tubulin 0.0055 0.0227 0.0685
Brugia malayi Trypsin family protein 0.0654 0.362 0.3617
Loa Loa (eye worm) hypothetical protein 0.0027 0.0072 0.0068
Trypanosoma brucei cdc2-related kinase 3 0.0054 0.0222 0.0667
Brugia malayi protein kinase C II. 0.0016 0.0006 0.0002
Onchocerca volvulus Huntingtin homolog 0.013 0.0653 0.1795
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0033 0.0102 0.0098
Loa Loa (eye worm) hypothetical protein 0.0033 0.0102 0.0098
Brugia malayi Tubulin alpha-2 chain 0.0064 0.0278 0.0274
Giardia lamblia Gamma tubulin 0.0055 0.0227 0.0659
Echinococcus multilocularis isocitrate dehydrogenase 0.0018 0.0018 0.0014
Echinococcus granulosus tubulin alpha 0.0055 0.0227 0.0223
Trypanosoma brucei glucosidase, putative 0.0035 0.0116 0.0319
Loa Loa (eye worm) hypothetical protein 0.0017 0.0015 0.001
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0037 0.0034
Loa Loa (eye worm) hypothetical protein 0.0033 0.0102 0.0098
Leishmania major beta tubulin 0.0055 0.0227 0.0685
Schistosoma mansoni serine/threonine protein kinase 0.0559 0.3078 0.3075
Plasmodium falciparum tubulin epsilon chain, putative 0.0055 0.0227 0.8051
Brugia malayi Steroid receptor seven-up type 2 0.0033 0.0102 0.0098
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0654 0.362 0.3617
Leishmania major beta tubulin 0.0055 0.0227 0.0685
Loa Loa (eye worm) hypothetical protein 0.0033 0.0102 0.0098
Onchocerca volvulus 0.0033 0.0102 0.027
Loa Loa (eye worm) tubulin alpha-3 chain 0.0033 0.0103 0.0098
Echinococcus granulosus protein kinase c epsilon type 0.0016 0.0006 0.0002
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0055 0.0227 0.0739
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0025 0.0056 0.0052
Trichomonas vaginalis tubulin epsilon chain, putative 0.0055 0.0227 0.0659
Loa Loa (eye worm) BEN-1 protein 0.0055 0.0227 0.0223
Leishmania major beta tubulin 0.0055 0.0227 0.0685
Giardia lamblia Delta tubulin 0.0024 0.0052 0.0084
Brugia malayi Tubulin gamma chain 0.0055 0.0227 0.0223
Leishmania major beta tubulin 0.0055 0.0227 0.0685
Echinococcus multilocularis lysosomal alpha glucosidase 0.0158 0.0812 0.0808
Schistosoma mansoni cyclin B3 0.0019 0.0026 0.0022
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0033 0.0102 0.0098
Loa Loa (eye worm) transcription factor SMAD2 0.0127 0.0634 0.0631
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0059 0.0251 0.0247
Loa Loa (eye worm) hypothetical protein 0.0654 0.362 0.3617
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0037 0.0034
Trypanosoma brucei beta tubulin 0.0055 0.0227 0.0685
Brugia malayi Tubulin alpha chain 0.0064 0.0278 0.0274
Schistosoma mansoni cercarial elastase (S01 family) 0.0654 0.362 0.3617
Leishmania major beta tubulin 0.0055 0.0227 0.0685
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0076 0.0349 0.0345
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0025 0.0056 0.0052
Loa Loa (eye worm) hypothetical protein 0.0654 0.362 0.3617
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0135 0.068 0.0676
Brugia malayi Protein kinase c protein 2 0.0016 0.0006 0.0002
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0033 0.0102 0.0098
Trichomonas vaginalis tubulin alpha chain, putative 0.0031 0.0093 0.0217
Entamoeba histolytica tubulin alpha-1 chain 0.0064 0.0278 0.7794
Brugia malayi protein kinase C3,putative 0.0016 0.0006 0.0002
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0033 0.0102 0.0098
Loa Loa (eye worm) hypothetical protein 0.0033 0.0102 0.0098
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0274 0.1469 0.1465
Schistosoma mansoni alpha-glucosidase 0.0136 0.0688 0.0684
Echinococcus granulosus GPCR family 2 0.005 0.0197 0.0193
Echinococcus multilocularis tubulin delta chain 0.0024 0.0052 0.0048
Entamoeba histolytica hypothetical protein 0.0076 0.0349 1
Schistosoma mansoni apoptosis regulator bax 0.1782 1 1
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0016 0.0006 0.0002
Giardia lamblia Beta tubulin 0.0055 0.0227 0.0659
Entamoeba histolytica cell division protein kinase 2, putative 0.0054 0.0222 0.6059
Echinococcus granulosus Tubulin beta 2C chain 0.0055 0.0227 0.0223
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0033 0.0102 0.0098
Loa Loa (eye worm) MH2 domain-containing protein 0.0127 0.0634 0.0631
Loa Loa (eye worm) hypothetical protein 0.0033 0.0103 0.0098
Trichomonas vaginalis tubulin, putative 0.0024 0.0052 0.0084
Schistosoma mansoni hypothetical protein 0.0654 0.362 0.3617
Schistosoma mansoni serine/threonine protein kinase 0.0334 0.1806 0.1803
Trypanosoma brucei beta tubulin 0.0055 0.0227 0.0685
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0559 0.3078 1
Entamoeba histolytica hypothetical protein 0.0076 0.0349 1
Echinococcus granulosus cyclins 0.0019 0.0026 0.0022
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0017 0.0015 0.001
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0018 0.0018 0.0014
Echinococcus multilocularis Tubulin beta 2C chain 0.0055 0.0227 0.0223
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.005 0.0197 0.0193
Echinococcus granulosus tyrosine protein kinase Lyn 0.0018 0.0018 0.0014
Schistosoma mansoni cercarial elastase (S01 family) 0.0654 0.362 0.3617
Trypanosoma cruzi epsilon tubulin, putative 0.0055 0.0227 0.0685
Giardia lamblia Alpha-tubulin 0.0064 0.0278 0.0825
Schistosoma mansoni tubulin subunit beta 0.0055 0.0227 0.0223
Plasmodium vivax tubulin beta chain, putative 0.0055 0.0227 0.8051
Brugia malayi MAP kinase sur-1 0.0559 0.3078 0.3075
Leishmania major alpha tubulin 0.0064 0.0278 0.085
Entamoeba histolytica tubulin family protein 0.0055 0.0227 0.6224
Trichomonas vaginalis tubulin gamma chain, putative 0.0055 0.0227 0.0659
Schistosoma mansoni tubulin subunit beta 0.0055 0.0227 0.0223
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0024 0.0052 0.5
Leishmania major beta tubulin 0.0055 0.0227 0.0685
Schistosoma mansoni cercarial elastase (S01 family) 0.0654 0.362 0.3617
Onchocerca volvulus 0.0046 0.0179 0.0484
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0033 0.0102 0.0098
Loa Loa (eye worm) hypothetical protein 0.1782 1 1
Loa Loa (eye worm) hypothetical protein 0.0064 0.0278 0.0274
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0334 0.1806 0.1803
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0559 0.3078 1
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0054 0.0222 0.0218
Loa Loa (eye worm) hypothetical protein 0.0033 0.0102 0.0098
Trypanosoma brucei beta tubulin 0.0055 0.0227 0.0685
Trichomonas vaginalis glucosylceramidase, putative 0.0274 0.1469 0.4727
Brugia malayi Protein kinase domain containing protein 0.0334 0.1806 0.1803
Echinococcus multilocularis musashi 0.0059 0.0251 0.0247
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0033 0.0102 0.0098
Toxoplasma gondii beta tubulin 0.0055 0.0227 0.0739
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0033 0.0102 0.0098
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.1782 1 1
Schistosoma mansoni tubulin subunit beta 0.0055 0.0227 0.0223
Leishmania major beta tubulin 0.0055 0.0227 0.0685
Loa Loa (eye worm) glutaminase 2 0.0265 0.1419 0.1415
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0033 0.0102 0.0098
Leishmania major alpha tubulin 0.0064 0.0278 0.085
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.0935 0.2978
Echinococcus granulosus raf serine:threonine protein kinase 0.0237 0.1257 0.1253
Trypanosoma cruzi cdc2-related kinase 3 0.0054 0.0222 0.0667
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0033 0.0102 0.0098
Schistosoma mansoni hypothetical protein 0.0367 0.1995 0.1992
Echinococcus multilocularis Tubulin alpha 1 chain 0.0064 0.0278 0.0274
Leishmania major alpha tubulin 0.0064 0.0278 0.085
Loa Loa (eye worm) apoptosis regulator protein 0.1782 1 1
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0018 0.0058
Brugia malayi hypothetical protein 0.013 0.0653 0.0649
Brugia malayi Trypsin family protein 0.0654 0.362 0.3617
Echinococcus multilocularis GPCR, family 2 0.005 0.0197 0.0193
Echinococcus multilocularis raf serine:threonine protein kinase 0.0237 0.1257 0.1253
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0334 0.1806 0.1803
Echinococcus multilocularis cyclins 0.0019 0.0026 0.0022
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0018 0.0018 0.0014
Echinococcus multilocularis cyclin dependent kinase 5 0.0054 0.0222 0.0218
Giardia lamblia Kinase, CMGC MAPK 0.0559 0.3078 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0055 0.0226 0.0681
Mycobacterium tuberculosis Cell division protein FtsZ 0.0024 0.0052 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0023 0.0048 0.0044
Schistosoma mansoni cyclins 0.0019 0.0026 0.0022
Loa Loa (eye worm) alpha-tubulin isotype 2 0.004 0.0143 0.0139
Brugia malayi tubulin alpha chain - mouse 0.0064 0.0278 0.0274
Schistosoma mansoni steroid hormone receptor ad4bp 0.0033 0.0102 0.0098
Trichomonas vaginalis tubulin epsilon chain, putative 0.0024 0.0052 0.0084
Echinococcus granulosus lysosomal alpha glucosidase 0.0158 0.0812 0.0808
Brugia malayi Protein kinase domain containing protein 0.0054 0.0222 0.0218
Echinococcus granulosus c-Jun N-terminal kinases 0.0258 0.1375 0.1372
Schistosoma mansoni thyroid hormone receptor 0.0033 0.0102 0.0098
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0021 0.0037 0.0034
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0046 0.0179 0.0527
Leishmania major epsilon tubulin, putative 0.0055 0.0227 0.0685
Leishmania major alpha tubulin 0.0064 0.0278 0.085
Leishmania major zeta tubulin, putative 0.0024 0.0052 0.0111
Schistosoma mansoni nuclear hormone receptor 0.0033 0.0102 0.0098
Plasmodium vivax delta tubulin, putative 0.0024 0.0052 0.1303
Echinococcus granulosus cyclin dependent kinase 0.0054 0.0222 0.0218
Loa Loa (eye worm) tubulin beta-2A chain 0.0055 0.0227 0.0223
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0033 0.0102 0.0098
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0559 0.3078 1
Loa Loa (eye worm) hypothetical protein 0.0654 0.362 0.3617
Echinococcus multilocularis cyclins 0.0019 0.0026 0.0022
Brugia malayi Raf kinase 0.0229 0.1211 0.1207
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0033 0.0102 0.0098
Brugia malayi latrophilin 2 splice variant baaae 0.0107 0.0522 0.0518
Echinococcus granulosus Tubulin beta 2C chain 0.0055 0.0227 0.0223
Trichomonas vaginalis tubulin beta chain, putative 0.0064 0.0278 0.0825
Leishmania major beta tubulin 0.0055 0.0227 0.0685
Echinococcus multilocularis microtubule associated protein 2 0.1466 0.821 0.8209
Schistosoma mansoni alpha tubulin 0.0064 0.0278 0.0274
Loa Loa (eye worm) CXXC zinc finger family protein 0.0093 0.0446 0.0442
Echinococcus granulosus cyclin B3 1 0.0019 0.0026 0.0022
Loa Loa (eye worm) tubulin beta chain 0.0024 0.0052 0.0048
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0018 0.0014
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0054 0.0222 0.0722
Loa Loa (eye worm) hypothetical protein 0.0046 0.0179 0.0175
Echinococcus granulosus tubulin beta 1 chain 0.0055 0.0227 0.0223
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0116 0.0293
Trypanosoma brucei zeta tubulin, putative 0.0024 0.0052 0.0111
Echinococcus granulosus Tubulin alpha 1 chain 0.0064 0.0278 0.0274
Echinococcus multilocularis Tubulin beta 2C chain 0.0055 0.0227 0.0223
Schistosoma mansoni tubulin subunit alpha 0.0064 0.0278 0.0274
Brugia malayi Cyclin, N-terminal domain containing protein 0.0046 0.0179 0.0175
Loa Loa (eye worm) tubulin alpha chain 0.0064 0.0278 0.0274
Echinococcus multilocularis tubulin gamma 1 chain 0.0055 0.0227 0.0223
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0035 0.0116 0.0112
Leishmania major beta tubulin 0.0055 0.0227 0.0685
Schistosoma mansoni cercarial elastase (S01 family) 0.0654 0.362 0.3617
Echinococcus multilocularis Tubulin alpha 1 chain 0.0064 0.0278 0.0274
Trichomonas vaginalis tubulin beta chain, putative 0.0055 0.0227 0.0659
Schistosoma mansoni alpha tubulin 0.0064 0.0278 0.0274
Echinococcus granulosus Protein kinase C brain isozyme 0.0016 0.0006 0.0002
Echinococcus multilocularis tubulin alpha chain 0.0064 0.0278 0.0274
Trichomonas vaginalis helicase, putative 0.0021 0.0037 0.0034
Onchocerca volvulus 0.0059 0.0251 0.0683
Toxoplasma gondii alpha tubulin TUBA1 0.0064 0.0278 0.0904
Loa Loa (eye worm) alpha-tubulin 0.0064 0.0278 0.0274
Loa Loa (eye worm) glutaminase 0.0265 0.1419 0.1415
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0033 0.0102 0.0098
Brugia malayi nuclear receptor NHR-88 0.0033 0.0102 0.0098
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0033 0.0102 0.0098
Brugia malayi Trypsin-like protease protein 5 0.0654 0.362 0.3617
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0016 0.0006 0.0002
Brugia malayi Glycosyl hydrolases family 31 protein 0.0158 0.0812 0.0808
Trichomonas vaginalis tubulin, putative 0.0031 0.0093 0.0217
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0064 0.0278 0.0825
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0037 0.0034
Leishmania major beta tubulin 0.0055 0.0227 0.0685
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0028 0.0078 0.0074
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0149 0.0759 0.0755
Leishmania major beta tubulin 0.0055 0.0227 0.0685
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0054 0.0222 0.0218
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0037 0.0034
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0018 0.0058
Trichomonas vaginalis maltase-glucoamylase, putative 0.0035 0.0116 0.0293
Brugia malayi hypothetical protein 0.0055 0.0226 0.0222
Echinococcus multilocularis FTZ F1 alpha 0.0033 0.0102 0.0098
Schistosoma mansoni atypical protein kinase C 0.0016 0.0006 0.0002
Loa Loa (eye worm) intermediate filament protein 0.0059 0.0251 0.0247
Loa Loa (eye worm) hypothetical protein 0.0654 0.362 0.3617
Echinococcus multilocularis beta tubulin 0.0055 0.0227 0.0223
Loa Loa (eye worm) hypothetical protein 0.0058 0.0245 0.0241
Trypanosoma cruzi tubulin delta chain 0.0024 0.0052 0.0111
Brugia malayi Glycosyl hydrolases family 31 protein 0.0035 0.0116 0.0112
Plasmodium vivax tubulin epsilon chain, putative 0.0055 0.0227 0.8051
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0033 0.0102 0.0098
Loa Loa (eye worm) isocitrate dehydrogenase 0.0018 0.0018 0.0014
Brugia malayi hypothetical protein 0.0035 0.0117 0.0113
Leishmania major delta tubulin, putative 0.0024 0.0052 0.0111
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0023 0.0048 0.0044
Trichomonas vaginalis cyclin B, putative 0.0046 0.0179 0.0501
Schistosoma mansoni hypothetical protein 0.0107 0.0522 0.0518
Loa Loa (eye worm) hypothetical protein 0.0055 0.0226 0.0222
Echinococcus multilocularis tubulin alpha chain 0.0064 0.0278 0.0274
Echinococcus multilocularis tubulin subunit beta 0.0055 0.0227 0.0223
Schistosoma mansoni lamin 0.0059 0.0251 0.0247
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0054 0.0222 0.0667
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0033 0.0102 0.0098
Echinococcus multilocularis cyclin dependent kinase 1 0.0054 0.0222 0.0218
Loa Loa (eye worm) raf kinase 0.0234 0.1244 0.124
Trypanosoma brucei alpha tubulin 0.0064 0.0278 0.085
Echinococcus multilocularis protein kinase c iota type 0.0016 0.0006 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0037 0.0034
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.0935 0.2978
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0016 0.0006 0.0002
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0016 0.0006 0.0002
Trypanosoma brucei PAB1-binding protein , putative 0.0055 0.0226 0.0681
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0654 0.362 0.3617
Schistosoma mansoni tubulin subunit beta 0.0055 0.0227 0.0223
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.0935 0.2978
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0654 0.362 0.3617
Leishmania major alpha tubulin 0.0064 0.0278 0.085
Brugia malayi Cell division protein ftsZ 0.0024 0.0052 0.0048
Schistosoma mansoni hypothetical protein 0.005 0.0197 0.0193
Schistosoma mansoni hypothetical protein 0.0076 0.0349 0.0345
Onchocerca volvulus Huntingtin homolog 0.013 0.0653 0.1795
Leishmania major alpha tubulin 0.0064 0.0278 0.085
Echinococcus multilocularis Tubulin alpha 1 chain 0.0064 0.0278 0.0274
Giardia lamblia Beta tubulin 0.0055 0.0227 0.0659
Loa Loa (eye worm) tubulin alpha 2 0.004 0.0143 0.0139
Plasmodium falciparum cyclin 0.0019 0.0026 0.0322
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0016 0.0006 0.0002
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0035 0.0116 0.0376
Echinococcus multilocularis tubulin alpha 1C chain 0.0064 0.0278 0.0274
Plasmodium vivax tubulin alpha chain, putative 0.0064 0.0278 1
Giardia lamblia Epsilon tubulin 0.0024 0.0052 0.0084
Echinococcus granulosus cyclin B 0.0046 0.0179 0.0175
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0016 0.0006 0.0002
Plasmodium vivax tubulin gamma chain, putative 0.0055 0.0227 0.8051
Trypanosoma brucei alpha tubulin, putative 0.0031 0.0093 0.0244
Loa Loa (eye worm) steroid hormone receptor 0.0033 0.0102 0.0098
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0037 0.0034
Echinococcus multilocularis tubulin beta 1 chain 0.0055 0.0227 0.0223
Echinococcus granulosus Tubulin alpha 1 chain 0.0064 0.0278 0.0274
Schistosoma mansoni intermediate filament proteins 0.0059 0.0251 0.0247
Leishmania major beta tubulin 0.0055 0.0227 0.0685
Loa Loa (eye worm) hypothetical protein 0.0654 0.362 0.3617
Echinococcus granulosus Tubulin beta 2C chain 0.0055 0.0227 0.0223
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0116 0.0293
Trichomonas vaginalis glutaminase, putative 0.0265 0.1419 0.4563
Loa Loa (eye worm) hypothetical protein 0.0156 0.0802 0.0799
Trypanosoma brucei epsilon tubulin 0.0055 0.0227 0.0685
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.005 0.0197 0.0193
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0054 0.0222 0.0667
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.0935 0.2978
Loa Loa (eye worm) hypothetical protein 0.0033 0.0102 0.0098
Onchocerca volvulus 0.0654 0.362 1
Echinococcus granulosus cyclins 0.0019 0.0026 0.0022
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0031 0.0093 0.0217
Echinococcus multilocularis cyclin B 0.0046 0.0179 0.0175
Brugia malayi F/Y-rich N-terminus family protein 0.0029 0.0079 0.0074
Echinococcus multilocularis cyclins 0.0019 0.0026 0.0022
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0021 0.0037 0.0034
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0052 0.0084
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0033 0.0102 0.0098
Echinococcus granulosus cyclins 0.0019 0.0026 0.0022
Schistosoma mansoni thyroid hormone receptor 0.0033 0.0102 0.0098
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0033 0.0102 0.0098
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.1782 1 1
Echinococcus granulosus cpg binding protein 0.0099 0.0476 0.0472
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0654 0.362 0.3617
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0018 0.0014
Loa Loa (eye worm) hypothetical protein 0.013 0.0653 0.0649
Leishmania major alpha tubulin 0.0064 0.0278 0.085
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0149 0.0759 0.0755
Trypanosoma brucei mitotic cyclin 6 0.0046 0.0179 0.0527
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0033 0.0102 0.0098
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.0935 0.2978
Trichomonas vaginalis glucosylceramidase, putative 0.019 0.099 0.3158
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0149 0.0759 0.0755
Brugia malayi Nuclear hormone receptor-like 1 0.0033 0.0102 0.0098
Loa Loa (eye worm) trypsin family protein 0.0654 0.362 0.3617
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0156 0.0802 0.0799
Echinococcus multilocularis cyclins 0.0019 0.0026 0.0022
Loa Loa (eye worm) hypothetical protein 0.0017 0.0015 0.001
Loa Loa (eye worm) histone methyltransferase 0.0029 0.0081 0.0076
Schistosoma mansoni tubulin subunit beta 0.0024 0.0052 0.0048
Trichomonas vaginalis tubulin beta chain, putative 0.0031 0.0093 0.0217
Loa Loa (eye worm) hypothetical protein 0.0027 0.007 0.0066
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.0935 0.2978
Echinococcus granulosus cyclin b3 0.0019 0.0026 0.0022
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0274 0.1469 0.1465
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0033 0.0102 0.027
Loa Loa (eye worm) tubulin gamma chain 0.0055 0.0227 0.0223
Trichomonas vaginalis cyclin B, putative 0.0046 0.0179 0.0501
Trichomonas vaginalis sucrase-isomaltase, putative 0.0035 0.0116 0.0293
Echinococcus multilocularis tubulin epsilon chain 0.0055 0.0227 0.0223
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0033 0.0102 0.0098
Brugia malayi nuclear receptor RXR 0.0017 0.0015 0.001
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0149 0.0759 0.0755
Schistosoma mansoni cercarial elastase (S01 family) 0.0654 0.362 0.3617
Schistosoma mansoni cercarial elastase (S01 family) 0.0654 0.362 0.3617
Echinococcus multilocularis cyclin dependent kinase 0.0054 0.0222 0.0218
Trichomonas vaginalis CMGC family protein kinase 0.0559 0.3078 1
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0334 0.1806 0.1803
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0334 0.1806 0.4984
Loa Loa (eye worm) hypothetical protein 0.0033 0.0102 0.0098
Echinococcus granulosus ecdysone induced protein 78C 0.0033 0.0102 0.0098
Plasmodium vivax tubulin alpha chain, putative 0.0064 0.0278 1
Echinococcus multilocularis glycoprotein Antigen 5 0.0654 0.362 0.3617
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0559 0.3078 1
Echinococcus granulosus tubulin alpha chain 0.0064 0.0278 0.0274
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0222 0.0642
Trypanosoma brucei alpha tubulin 0.0064 0.0278 0.085
Trichomonas vaginalis tubulin gamma chain, putative 0.0055 0.0227 0.0659
Echinococcus multilocularis tubulin alpha 0.0055 0.0227 0.0223
Mycobacterium ulcerans hypothetical protein 0.0654 0.362 1
Schistosoma mansoni tubulin subunit alpha 0.0064 0.0278 0.0274
Echinococcus multilocularis Tubulin beta 2C chain 0.0055 0.0227 0.0223
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0033 0.0102 0.0098
Trichomonas vaginalis tubulin alpha chain, putative 0.0055 0.0227 0.0659
Brugia malayi steroid hormone receptor 0.0033 0.0102 0.0098
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.004 0.0143 0.0384
Brugia malayi ecdysteroid receptor 0.0033 0.0102 0.0098
Entamoeba histolytica hypothetical protein 0.0076 0.0349 1
Onchocerca volvulus Glucosylceramidase homolog 0.018 0.0935 0.2575
Trichomonas vaginalis glucosylceramidase, putative 0.0274 0.1469 0.4727
Loa Loa (eye worm) hypothetical protein 0.0654 0.362 0.3617
Schistosoma mansoni microtubule-associated protein tau 0.1466 0.821 0.8209
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0654 0.362 0.3617
Trypanosoma cruzi cdc2-related kinase 3 0.0054 0.0222 0.0667
Loa Loa (eye worm) hypothetical protein 0.0654 0.362 0.3617
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.0116 0.0112
Trypanosoma cruzi tubulin delta chain 0.0024 0.0052 0.0111
Onchocerca volvulus 0.0654 0.362 1
Echinococcus multilocularis tubulin alpha 3 chain 0.0064 0.0278 0.0274
Brugia malayi intermediate filament protein 0.0059 0.0251 0.0247
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0559 0.3078 1
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0334 0.1806 0.1803
Toxoplasma gondii beta-1 tubulin, putative 0.0055 0.0227 0.0739
Leishmania major alpha tubulin 0.0064 0.0278 0.085
Leishmania major hypothetical protein, conserved 0.0055 0.0226 0.0681
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0258 0.1375 0.1372
Leishmania major beta tubulin 0.0055 0.0227 0.0685
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0149 0.0759 0.0755
Plasmodium vivax ataxin-2 like protein, putative 0.0055 0.0226 0.8005
Loa Loa (eye worm) tubulin alpha-2 chain 0.0064 0.0278 0.0274
Brugia malayi glutaminase DH11.1 0.0265 0.1419 0.1415
Schistosoma mansoni tubulin subunit alpha 0.0024 0.0052 0.0048
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0033 0.0102 0.0098
Echinococcus multilocularis Mastin 0.0654 0.362 0.3617
Leishmania major alpha glucosidase II subunit, putative 0.0035 0.0116 0.0319
Trichomonas vaginalis glucosylceramidase, putative 0.0274 0.1469 0.4727
Trypanosoma cruzi cdc2-related kinase 1 0.0054 0.0222 0.0667
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0052 0.0084
Trypanosoma brucei beta tubulin 0.0055 0.0227 0.0685
Echinococcus multilocularis tubulin subunit TubB 0.0064 0.0278 0.0274
Echinococcus multilocularis cyclins 0.0019 0.0026 0.0022
Trichomonas vaginalis tubulin alpha chain, putative 0.0055 0.0227 0.0659
Loa Loa (eye worm) tubulin beta chain 0.0055 0.0227 0.0223
Schistosoma mansoni tubulin subunit delta 0.0024 0.0052 0.0048
Echinococcus multilocularis tubulin alpha chain 0.0064 0.0278 0.0274
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0334 0.1806 0.1803
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0654 0.362 0.3617
Trypanosoma brucei zeta tubulin 0.0024 0.0052 0.0111
Schistosoma mansoni hypothetical protein 0.005 0.0197 0.0193

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 17 nM Cytotoxicity against human SKOV3 cells after 48 hrs by MTT assay ChEMBL. 24269481

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 24269481

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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