Detailed information for compound 1986838

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 606.721 | Formula: C33H38N10O2
  • H donors: 2 H acceptors: 6 LogP: 3.59 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: N#CC(c1cc(cc(c1)N1CCN(CC1)C)C(=O)Nc1ccc(c(c1)Nc1ncnc2c1nc(nc2)N1CCOCC1)C)(C)C
  • InChi: 1S/C33H38N10O2/c1-22-5-6-25(18-27(22)39-30-29-28(36-21-37-30)19-35-32(40-29)43-11-13-45-14-12-43)38-31(44)23-15-24(33(2,3)20-34)17-26(16-23)42-9-7-41(4)8-10-42/h5-6,15-19,21H,7-14H2,1-4H3,(H,38,44)(H,36,37,39)
  • InChiKey: QDJPTVRBNFTFNT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens B-Raf proto-oncogene, serine/threonine kinase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis raf serine:threonine protein kinase Get druggable targets OG5_130459 All targets in OG5_130459
Brugia malayi Raf kinase Get druggable targets OG5_130459 All targets in OG5_130459
Schistosoma japonicum ko:K04365 B-Raf proto-oncogene serine/threonine-protein kinase, putative Get druggable targets OG5_130459 All targets in OG5_130459
Echinococcus granulosus raf serine:threonine protein kinase Get druggable targets OG5_130459 All targets in OG5_130459
Loa Loa (eye worm) TKL/RAF/RAF protein kinase Get druggable targets OG5_130459 All targets in OG5_130459
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_130459 All targets in OG5_130459
Loa Loa (eye worm) raf kinase Get druggable targets OG5_130459 All targets in OG5_130459
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi hypothetical protein 0.0139 0.0154 0.0324
Loa Loa (eye worm) hypothetical protein 0.0029 0.0018 0.0055
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0263 0.0307 0.0307
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0018 0.0005 0.0015
Onchocerca volvulus 0.0039 0.0031 0.0111
Loa Loa (eye worm) hypothetical protein 0.0139 0.0154 0.0467
Echinococcus multilocularis GA binding protein alpha chain 0.0048 0.0042 0.0049
Onchocerca volvulus 0.0025 0.0014 0.005
Loa Loa (eye worm) hypothetical protein 0.0075 0.0075 0.0229
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0075 0.0075 0.0089
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0016 0.0003 0.0067
Mycobacterium leprae PROBABLE HYDROLASE 0.0048 0.0042 0.3105
Loa Loa (eye worm) neuropeptide F receptor 0.0075 0.0075 0.0229
Echinococcus multilocularis serotonin transporter 0.2283 0.2795 0.3295
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0018 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0124 0.0136 0.0412
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0107 0.0115 0.2463
Onchocerca volvulus 0.0039 0.0031 0.0111
Schistosoma mansoni aldehyde dehydrogenase 0.0094 0.0098 0.0098
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0075 0.0075 0.0089
Echinococcus multilocularis rhodopsin orphan GPCR 0.0075 0.0075 0.0089
Echinococcus multilocularis neuropeptide s receptor 0.0396 0.0471 0.0556
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0016 0.0003 0.0067
Echinococcus granulosus g protein coupled receptor 0.0075 0.0075 0.0089
Loa Loa (eye worm) nuclear hormone receptor 0.0124 0.0136 0.0412
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0394 0.0468 0.0468
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0015
Brugia malayi hypothetical protein 0.0075 0.0075 0.0159
Brugia malayi Furin-like cysteine rich region family protein 0.0106 0.0114 0.024
Schistosoma mansoni hypothetical protein 0.002 0.0007 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0012 0.0691
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0015
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0263 0.0307 0.0361
Brugia malayi Amino acid permease family protein 0.0029 0.0018 0.0038
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0075 0.0075 0.0075
Echinococcus granulosus p2X purinoceptor 4 0.0023 0.0011 0.0013
Echinococcus granulosus cpg binding protein 0.0041 0.0034 0.004
Echinococcus granulosus biogenic amine 5HT receptor 0.0363 0.043 0.0507
Mycobacterium tuberculosis Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) 0.0117 0.0127 0.0732
Echinococcus granulosus prolyl endopeptidase 0.0023 0.0012 0.0014
Onchocerca volvulus 0.0394 0.0468 0.1674
Loa Loa (eye worm) hypothetical protein 0.0075 0.0075 0.0229
Echinococcus granulosus Lysosomal Pro X carboxypeptidase 0.0018 0.0005 0.0006
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0139 0.0154 0.0154
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0023 0.0012 0.0187
Schistosoma mansoni hypothetical protein 0.0074 0.0075 0.0075
Brugia malayi Serine protease Z688.6 precursor 0.0018 0.0005 0.001
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0019 0.004
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0026 0.0015 0.0017
Brugia malayi protein-tyrosine kinase 0.0026 0.0015 0.0031
Schistosoma mansoni P2X receptor subunit 0.0023 0.0011 0.0011
Echinococcus multilocularis transcription factor btf3 0.0023 0.0012 0.0014
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0263 0.0307 0.0646
Schistosoma mansoni steroid hormone receptor ad4bp 0.0263 0.0307 0.0307
Onchocerca volvulus 0.0058 0.0055 0.0195
Schistosoma mansoni nuclear hormone receptor 0.0124 0.0136 0.0136
Schistosoma mansoni survival motor neuron protein 0.0074 0.0075 0.0075
Schistosoma mansoni tyrosine kinase 0.0035 0.0027 0.0027
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0005 0.0011
Schistosoma mansoni thyroid hormone receptor 0.0263 0.0307 0.0307
Brugia malayi bHLH-PAS transcription factor 0.0025 0.0014 0.003
Trypanosoma cruzi UDP-galactopyranose mutase 0.0107 0.0115 0.2486
Echinococcus multilocularis Lysosomal Pro X carboxypeptidase 0.0018 0.0005 0.0006
Brugia malayi hypothetical protein 0.0075 0.0075 0.0159
Trypanosoma brucei oligopeptidase b 0.0023 0.0012 0.0187
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0263 0.0307 0.0646
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0263 0.0307 0.0646
Onchocerca volvulus 0.0075 0.0075 0.027
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0263 0.0307 0.0646
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0015
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0015
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0075 0.0075 0.0089
Brugia malayi Cation transporter family protein 0.0018 0.0005 0.0011
Plasmodium vivax basic transcription factor 3b, putative 0.0023 0.0012 0.0247
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0018 0.0005 0.0015
Loa Loa (eye worm) hypothetical protein 0.0139 0.0154 0.0467
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0075 0.0075 0.0075
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0098 0.0104 0.2226
Brugia malayi Integrin beta pat-3 precursor 0.0141 0.0156 0.0329
Echinococcus multilocularis fmrfamide receptor 0.0075 0.0075 0.0089
Brugia malayi conserved hypotetical protein 0.0124 0.0136 0.0286
Brugia malayi ORL1-like opioid receptor 0.0075 0.0075 0.0159
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0039 0.0031 0.0031
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.1524 0.186 1
Loa Loa (eye worm) hypothetical protein 0.0124 0.0136 0.0412
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0075 0.0075 0.0159
Trypanosoma cruzi cytochrome P450, putative 0.0018 0.0006 0.0021
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0394 0.0468 0.0552
Schistosoma mansoni lipoxygenase 0.0082 0.0085 0.0085
Loa Loa (eye worm) melatonin receptor type 1A 0.0075 0.0075 0.0229
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0155 0.0174 0.3728
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0075 0.0075 0.0075
Plasmodium falciparum protoporphyrinogen oxidase 0.0107 0.0115 0.2463
Loa Loa (eye worm) hypothetical protein 0.0026 0.0015 0.0047
Schistosoma mansoni aldehyde dehydrogenase 0.0094 0.0098 0.0098
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0075 0.0075 0.0075
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0052 0.0047 0.0055
Echinococcus granulosus tyrosine protein kinase Src42A 0.0023 0.0011 0.0013
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0263 0.0307 0.0307
Brugia malayi G protein-coupled receptor 0.0075 0.0075 0.0159
Loa Loa (eye worm) hypothetical protein 0.0058 0.0055 0.0166
Schistosoma mansoni thyroid hormone receptor 0.0263 0.0307 0.0307
Trichomonas vaginalis inositol monophosphatase, putative 0.0031 0.0021 0.1711
Loa Loa (eye worm) hypothetical protein 0.0024 0.0013 0.004
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0018 0.0005 0.0006
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0094 0.0098 0.0116
Loa Loa (eye worm) hypothetical protein 0.0052 0.0047 0.0142
Echinococcus multilocularis transfer RNA-Lys 0.0025 0.0014 0.0017
Onchocerca volvulus 0.0074 0.0075 0.0267
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.002 0.0007 0.0015
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0075 0.0075 0.0075
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0005 0.0011
Schistosoma mansoni tyrosine kinase 0.0106 0.0114 0.0114
Mycobacterium ulcerans aldehyde dehydrogenase 0.0094 0.0098 0.0528
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.0949 0.1151 0.1151
Onchocerca volvulus 0.0075 0.0075 0.027
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0263 0.0307 0.0931
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0263 0.0307 0.0646
Schistosoma mansoni opsin-like receptor 0.0075 0.0075 0.0075
Schistosoma mansoni neuropeptide receptor 0.0075 0.0075 0.0075
Onchocerca volvulus 0.0075 0.0075 0.027
Schistosoma mansoni tyrosine kinase 0.0058 0.0055 0.0054
Echinococcus multilocularis g protein coupled receptor 0.0075 0.0075 0.0089
Trypanosoma cruzi oligopeptidase b 0.0023 0.0012 0.0149
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0019 0.0007 0.0008
Schistosoma mansoni P2X receptor subunit 0.0023 0.0011 0.0011
Echinococcus granulosus Dipeptidyl peptidase 9 0.0098 0.0104 0.0122
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0031 0.0021 0.0374
Schistosoma mansoni neuropeptide receptor 0.0075 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.0394 0.0468 0.1421
Loa Loa (eye worm) hypothetical protein 0.0043 0.0037 0.0111
Brugia malayi amine oxidase, flavin-containing family protein 0.0107 0.0115 0.0243
Echinococcus multilocularis glycine receptor subunit beta 0.0018 0.0005 0.0006
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0059 0.0056 0.2996
Loa Loa (eye worm) amino acid permease 0.0029 0.0018 0.0055
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0023 0.0012 0.0179
Onchocerca volvulus 0.2283 0.2795 1
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0394 0.0468 0.1421
Mycobacterium tuberculosis Probable peptidase 0.0023 0.0012 0.0065
Brugia malayi nuclear hormone receptor 0.0263 0.0307 0.0646
Brugia malayi Latrophilin receptor protein 2 0.002 0.0007 0.0015
Trypanosoma brucei prolyl endopeptidase 0.0023 0.0012 0.0187
Loa Loa (eye worm) CYP4Cod1 0.0018 0.0006 0.0018
Onchocerca volvulus 0.0052 0.0047 0.0167
Brugia malayi prolyl oligopeptidase family protein 0.0023 0.0012 0.0024
Brugia malayi Hemopexin family protein 0.0037 0.0029 0.0062
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0015
Echinococcus multilocularis neuropeptide receptor 0.0075 0.0075 0.0089
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0291 0.0342 0.0342
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0018 0.0005 0.0006
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0028 0.0018 0.0021
Schistosoma mansoni hypothetical protein 0.0037 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0075 0.0075 0.0229
Schistosoma mansoni amine oxidase 0.0107 0.0115 0.0115
Echinococcus multilocularis jun protein 0.0059 0.0055 0.0065
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0018 0.0005 0.0005
Plasmodium falciparum ataxin-2 like protein, putative 0.0021 0.0009 0.0198
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0023 0.0012 0.0187
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0263 0.0307 0.0646
Brugia malayi nuclear hormone receptor family member odr-7 0.0124 0.0136 0.0286
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0043 0.0036 0.0707
Onchocerca volvulus 0.0018 0.0005 0.0018
Trypanosoma cruzi PAB1-binding protein , putative 0.0021 0.0009 0.0099
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0124 0.0136 0.016
Schistosoma mansoni lipoxygenase 0.0058 0.0054 0.0054
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0045 0.0038 0.0744
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0424 0.0505 0.1064
Schistosoma mansoni gabp alpha 0.0048 0.0042 0.0042
Brugia malayi Dopamine receptor protein 2 0.0075 0.0075 0.0159
Loa Loa (eye worm) hypothetical protein 0.0114 0.0124 0.0375
Loa Loa (eye worm) hypothetical protein 0.0024 0.0013 0.004
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0263 0.0307 0.0361
Entamoeba histolytica protein kinase, putative 0.0023 0.0011 0.4474
Schistosoma mansoni sodium-dependent amino acid transporter 0.0394 0.0468 0.0468
Mycobacterium tuberculosis Conserved hypothetical protein 0.0107 0.0115 0.0666
Schistosoma mansoni hypothetical protein 0.0118 0.0129 0.0129
Brugia malayi prolyl oligopeptidase family protein 0.0023 0.0012 0.0024
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.0015 0.0018
Brugia malayi Sodium:neurotransmitter symporter family protein 0.2283 0.2795 0.589
Echinococcus granulosus tyrosine protein kinase Src64B 0.0028 0.0018 0.0021
Brugia malayi hypothetical protein 0.0022 0.001 0.0022
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0075 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.0124 0.0136 0.0412
Echinococcus multilocularis L aminoadipate semialdehyde 0.0058 0.0055 0.0064
Echinococcus multilocularis acylamino acid releasing enzyme 0.0023 0.0012 0.0014
Mycobacterium tuberculosis Possible oxidoreductase 0.0107 0.0115 0.0666
Echinococcus granulosus rhodopsin orphan GPCR 0.0075 0.0075 0.0089
Schistosoma mansoni tyrosine kinase 0.0058 0.0055 0.0054
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0052 0.0047 0.0055
Echinococcus multilocularis allatostatin A receptor 0.0075 0.0075 0.0089
Echinococcus granulosus nAChR subunit 0.0018 0.0005 0.0006
Brugia malayi Intermediate filament tail domain containing protein 0.0054 0.005 0.0106
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0018 0.0005 0.0005
Echinococcus granulosus intermediate filament protein 0.0054 0.005 0.0059
Loa Loa (eye worm) solute carrier family 6 member 4 0.2283 0.2795 0.8487
Onchocerca volvulus 0.0075 0.0075 0.027
Loa Loa (eye worm) G-protein coupled receptor 0.0075 0.0075 0.0229
Brugia malayi Matrixin family protein 0.0076 0.0077 0.0163
Schistosoma mansoni biogenic amine (5HT) receptor 0.0363 0.043 0.043
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0052 0.0047 0.0055
Onchocerca volvulus 0.0046 0.004 0.0142
Loa Loa (eye worm) hypothetical protein 0.0124 0.0136 0.0412
Loa Loa (eye worm) hypothetical protein 0.0124 0.0136 0.0412
Echinococcus granulosus insulin receptor 0.0035 0.0027 0.0031
Echinococcus granulosus Nuclear hormone receptor HR96 0.0124 0.0136 0.016
Schistosoma mansoni hypothetical protein 0.0201 0.0231 0.0231
Brugia malayi nuclear hormone receptor family member nhr-6 0.0124 0.0136 0.0286
Loa Loa (eye worm) ICD-1 protein 0.0023 0.0012 0.0035
Schistosoma mansoni hypothetical protein 0.0555 0.0667 0.0667
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0124 0.0136 0.0412
Echinococcus multilocularis neuropeptide Y receptor 0.0075 0.0075 0.0089
Echinococcus multilocularis dro:myosuppressin receptor 0.0075 0.0075 0.0089
Treponema pallidum polypeptide deformylase (def) 0.0117 0.0127 0.0453
Brugia malayi Dopamine receptor protein 1 0.0075 0.0075 0.0159
Leishmania major C-8 sterol isomerase-like protein 0.0378 0.0449 1
Schistosoma mansoni nAChR subunit 0.0018 0.0005 0.0005
Brugia malayi hypothetical protein 0.0075 0.0075 0.0159
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0075 0.0075 0.0089
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0094 0.0098 0.2138
Onchocerca volvulus 0.0107 0.0115 0.0412
Entamoeba histolytica serine carboxypeptidase (S28) family protein 0.0018 0.0005 0.0926
Loa Loa (eye worm) hypothetical protein 0.0075 0.0075 0.0229
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0018 0.0006 0.003
Loa Loa (eye worm) hypothetical protein 0.0075 0.0075 0.0229
Brugia malayi Matrixin family protein 0.0039 0.0031 0.0066
Trichomonas vaginalis CMGC family protein kinase 0.0043 0.0036 0.3215
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0075 0.0075 0.0089
Schistosoma mansoni amine GPCR 0.0075 0.0075 0.0075
Echinococcus granulosus tyrosine protein kinase Lyn 0.0029 0.0018 0.0021
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0098 0.0104 0.2163
Schistosoma mansoni lysosomal Pro-Xaa carboxypeptidase (S28 family) 0.0018 0.0005 0.0005
Brugia malayi hypothetical protein 0.0124 0.0136 0.0286
Echinococcus multilocularis mitogen activated protein kinase 0.0043 0.0036 0.0042
Loa Loa (eye worm) hypothetical protein 0.0022 0.001 0.0031
Loa Loa (eye worm) CXXC zinc finger family protein 0.0039 0.0031 0.0094
Schistosoma mansoni nuclear receptor nhr-48 0.0124 0.0136 0.0136
Loa Loa (eye worm) hypothetical protein 0.0075 0.0075 0.0229
Echinococcus granulosus tyrosine protein kinase Fyn 0.0028 0.0018 0.0021
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0043 0.0036 0.0737
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0263 0.0307 0.0361
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0263 0.0307 0.0931
Loa Loa (eye worm) hypothetical protein 0.0075 0.0075 0.0229
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0378 0.0449 0.0946
Brugia malayi hypothetical protein 0.0075 0.0075 0.0159
Schistosoma mansoni tyrosine kinase 0.0055 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0075 0.0075 0.0229
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0124 0.0136 0.016
Loa Loa (eye worm) NNMT/PNMT/TEMT family protein 0.2688 0.3293 1
Trypanosoma cruzi Peptide deformylase 2, putative 0.0045 0.0038 0.0744
Loa Loa (eye worm) hypothetical protein 0.0075 0.0075 0.0229
Brugia malayi hypothetical protein 0.0124 0.0136 0.0286
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0263 0.0307 0.0307
Loa Loa (eye worm) LGC-31 protein 0.0018 0.0005 0.0015
Loa Loa (eye worm) hypothetical protein 0.0364 0.0432 0.1311
Loa Loa (eye worm) hypothetical protein 0.0075 0.0075 0.0229
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0015
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0005 0.0011
Echinococcus multilocularis neuropeptide receptor A26 0.0396 0.0471 0.0556
Brugia malayi beta-NAC-like protein 0.0023 0.0012 0.0024
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0015
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0075 0.0075 0.0075
Echinococcus granulosus epidermal growth factor receptor 0.0058 0.0055 0.0064
Echinococcus granulosus ecdysone induced protein 78C 0.0263 0.0307 0.0361
Plasmodium falciparum peptidase, putative 0.0023 0.0012 0.0245
Brugia malayi latrophilin 2 splice variant baaae 0.0042 0.0035 0.0074
Echinococcus multilocularis neuropeptide receptor 0.0075 0.0075 0.0089
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0096 0.0102 1
Loa Loa (eye worm) hypothetical protein 0.0075 0.0075 0.0229
Mycobacterium ulcerans putative regulatory protein 0.0025 0.0014 0.0074
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0026 0.0015 0.0017
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0394 0.0468 0.0552
Brugia malayi Serine carboxypeptidase S28 family protein 0.0018 0.0005 0.001
Loa Loa (eye worm) hypothetical protein 0.0394 0.0468 0.1421
Onchocerca volvulus 0.0263 0.0307 0.1097
Echinococcus granulosus rhodopsin orphan GPCR 0.0075 0.0075 0.0089
Loa Loa (eye worm) hypothetical protein 0.0075 0.0075 0.0229
Loa Loa (eye worm) hypothetical protein 0.0075 0.0075 0.0229
Plasmodium vivax hypothetical protein, conserved 0.0107 0.0115 0.2463
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.011 0.0118 0.2475
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0394 0.0468 0.0468
Schistosoma mansoni nuclear receptor 0.0124 0.0136 0.0136
Echinococcus multilocularis insulin receptor 0.0035 0.0027 0.0031
Echinococcus multilocularis serotonin receptor 0.016 0.018 0.0212
Loa Loa (eye worm) matrixin family protein 0.0076 0.0077 0.0234
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0394 0.0468 0.0552
Loa Loa (eye worm) hypothetical protein 0.0053 0.0049 0.0148
Onchocerca volvulus 0.0075 0.0075 0.027
Echinococcus multilocularis g-protein coupled receptor 0.0075 0.0075 0.0089
Loa Loa (eye worm) hypothetical protein 0.0075 0.0075 0.0229
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0394 0.0468 0.0468
Schistosoma mansoni neuropeptide f receptor 76f 0.0075 0.0075 0.0075
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0059 0.0056 0.2996
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0062 0.0059 0.0125
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0043 0.0036 0.0109
Schistosoma mansoni retinoic acid receptor RXR 0.0263 0.0307 0.0307
Echinococcus granulosus mitogen activated protein kinase 3 0.0043 0.0036 0.0042
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0263 0.0307 0.0931
Echinococcus multilocularis nAChR subunit 0.0018 0.0005 0.0006
Echinococcus granulosus raf serine:threonine protein kinase 0.0263 0.0307 0.0362
Brugia malayi Cation transporter family protein 0.0018 0.0005 0.0011
Brugia malayi sulfakinin receptor protein 0.0075 0.0075 0.0159
Onchocerca volvulus 0.0075 0.0075 0.027
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0075 0.0075 0.0075
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0094 0.0098 0.0568
Echinococcus multilocularis rhodopsin orphan GPCR 0.0075 0.0075 0.0089
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0018 0.0005 0.0011
Echinococcus granulosus transcription factor btf3 0.0023 0.0012 0.0014
Loa Loa (eye worm) hypothetical protein 0.0075 0.0075 0.0229
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0018 0.0005 0.0006
Loa Loa (eye worm) ACC-1 protein 0.0018 0.0005 0.0015
Schistosoma mansoni amine GPCR 0.0075 0.0075 0.0075
Brugia malayi putative neuropeptide receptor 0.0075 0.0075 0.0159
Loa Loa (eye worm) hypothetical protein 0.0023 0.0012 0.0035
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0031 0.0021 0.1479
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0394 0.0468 0.0468
Leishmania major hypothetical protein, conserved 0.0021 0.0009 0.0137
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0031 0.0021 0.1711
Brugia malayi G-protein coupled receptor 0.0075 0.0075 0.0159
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0052 0.0047 0.0047
Schistosoma mansoni biogenic amine (5HT) receptor 0.016 0.018 0.018
Echinococcus multilocularis rhodopsin orphan GPCR 0.0075 0.0075 0.0089
Loa Loa (eye worm) TK protein kinase 0.0026 0.0015 0.0044
Loa Loa (eye worm) hypothetical protein 0.2283 0.2795 0.8487
Schistosoma mansoni serine/threonine protein kinase 0.0043 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0015
Loa Loa (eye worm) hypothetical protein 0.0023 0.0012 0.0035
Schistosoma mansoni hypothetical protein 0.0075 0.0075 0.0075
Schistosoma mansoni opsin-like receptor 0.0075 0.0075 0.0075
Brugia malayi prolyl oligopeptidase family protein 0.0098 0.0104 0.0219
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0023 0.0012 0.0683
Loa Loa (eye worm) hypothetical protein 0.0075 0.0075 0.0229
Echinococcus multilocularis protoporphyrinogen oxidase 0.0107 0.0115 0.0136
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0059 0.0056 0.1189
Echinococcus multilocularis mitogen activated protein kinase 3 0.0043 0.0036 0.0042
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.0015 0.0018
Loa Loa (eye worm) TYRA-2 protein 0.0075 0.0075 0.0229
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0394 0.0468 0.0986
Schistosoma mansoni hypothetical protein 0.002 0.0007 0.0007
Brugia malayi hypothetical protein 0.0114 0.0124 0.026
Loa Loa (eye worm) SRC-1 0.0028 0.0018 0.0054
Echinococcus granulosus tyrosine protein kinase Blk 0.0026 0.0015 0.0017
Brugia malayi Ets-domain containing protein 0.0048 0.0042 0.0088
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0124 0.0136 0.0485
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0058 0.0055 0.0064
Schistosoma mansoni P2X receptor subunit 0.0023 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0107 0.0115 0.035
Loa Loa (eye worm) inositol-1 0.0031 0.0021 0.0065
Schistosoma mansoni intermediate filament proteins 0.0054 0.005 0.005
Brugia malayi hypothetical protein 0.0046 0.004 0.0084
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0018 0.0005 0.0015
Brugia malayi neuropeptide F receptor 0.0075 0.0075 0.0159
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0023 0.0012 0.4546
Brugia malayi hypothetical protein 0.0075 0.0075 0.0159
Trypanosoma brucei transcription factor BTF3, putative 0.0023 0.0012 0.0188
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0012 0.0691
Echinococcus granulosus nuclear receptor nhr 48 0.0124 0.0136 0.016
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0023 0.0012 0.0011
Schistosoma mansoni tyrosine kinase 0.0055 0.0051 0.0051
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0018 0.0005 0.0011
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0075 0.0075 0.0075
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0075 0.0075 0.0089
Loa Loa (eye worm) hypothetical protein 0.0075 0.0075 0.0229
Loa Loa (eye worm) hypothetical protein 0.0025 0.0014 0.0043
Echinococcus granulosus tm gpcr rhodopsin 0.0075 0.0075 0.0089
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0018 0.0005 0.0011
Loa Loa (eye worm) hypothetical protein 0.0075 0.0075 0.0229
Loa Loa (eye worm) hypothetical protein 0.0263 0.0307 0.0931
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0139 0.0154 0.0154
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0075 0.0075 0.027
Loa Loa (eye worm) norepinephrine transporter 0.2283 0.2795 0.8487
Loa Loa (eye worm) ACC-1 protein 0.0018 0.0005 0.0015
Schistosoma mansoni hypothetical protein 0.0042 0.0035 0.0035
Toxoplasma gondii aldehyde dehydrogenase 0.0094 0.0098 0.205
Loa Loa (eye worm) hypothetical protein 0.0424 0.0505 0.1533
Echinococcus granulosus lamin 0.0054 0.005 0.0059
Brugia malayi hypoxia-induced factor 1 0.0105 0.0113 0.0237
Echinococcus granulosus thyroid hormone receptor alpha 0.0124 0.0136 0.016
Brugia malayi Inositol-1 0.0031 0.0021 0.0045
Loa Loa (eye worm) nuclear receptor NHR-67 0.0124 0.0136 0.0412
Schistosoma mansoni nAChR subunit 0.0018 0.0005 0.0005
Onchocerca volvulus Huntingtin homolog 0.0067 0.0065 0.0234
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0018 0.0005 0.0011
Echinococcus granulosus rhodopsin orphan GPCR 0.0075 0.0075 0.0089
Loa Loa (eye worm) hypothetical protein 0.0107 0.0115 0.035
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0075 0.0075 0.0075
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0139 0.0154 0.0467
Brugia malayi excitatory GABA receptor EXP-1A 0.0018 0.0005 0.0011
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0051 0.0046 0.0055
Echinococcus granulosus somatostatin receptor 0.0075 0.0075 0.0089
Echinococcus multilocularis tyrosine protein kinase Srms 0.0026 0.0015 0.0017
Toxoplasma gondii serine carboxypeptidase s28 protein 0.0018 0.0005 0.0036
Mycobacterium ulcerans dehydrogenase 0.0107 0.0115 0.0618
Entamoeba histolytica hypothetical protein 0.0023 0.0012 0.4589
Schistosoma mansoni sodium/chloride dependent transporter 0.0424 0.0505 0.0505
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0059 0.0055 0.0065
Plasmodium falciparum basic transcription factor 3b, putative 0.0023 0.0012 0.0247
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0075 0.0075 0.0089
Loa Loa (eye worm) hypothetical protein 0.0057 0.0053 0.0162
Loa Loa (eye worm) hypothetical protein 0.0075 0.0075 0.0229
Loa Loa (eye worm) raf kinase 0.026 0.0304 0.0922
Onchocerca volvulus 0.0018 0.0005 0.0017
Echinococcus multilocularis tumor protein p63 0.0236 0.0274 0.0323
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0263 0.0307 0.0361
Schistosoma mansoni ets-related 0.0145 0.0161 0.0161
Loa Loa (eye worm) matrix metalloproteinase 0.0039 0.0031 0.0094
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0075 0.0075 0.0159
Echinococcus granulosus rhodopsin orphan GPCR 0.0075 0.0075 0.0089
Brugia malayi photoreceptor-specific nuclear receptor 0.0263 0.0307 0.0646
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0031 0.0021 1
Echinococcus multilocularis cpg binding protein 0.0041 0.0034 0.004
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0155 0.0174 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0124 0.0136 0.016
Onchocerca volvulus 0.0124 0.0136 0.0485
Echinococcus multilocularis neuropeptide Y receptor 0.0075 0.0075 0.0089
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0263 0.0307 0.0361
Loa Loa (eye worm) hypothetical protein 0.0378 0.0449 0.1363
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0394 0.0468 0.0986
Schistosoma mansoni aryl hydrocarbon receptor 0.0034 0.0025 0.0025
Brugia malayi hypothetical protein 0.0021 0.0009 0.002
Brugia malayi Steroid receptor seven-up type 2 0.0263 0.0307 0.0646
Loa Loa (eye worm) hypothetical protein 0.0029 0.0018 0.0055
Schistosoma mansoni cpg binding protein 0.0041 0.0034 0.0034
Echinococcus granulosus lamin dm0 0.0054 0.005 0.0059
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0378 0.0449 1
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0023 0.0011 0.0013
Echinococcus granulosus 7TM GPCR rhodopsin 0.0075 0.0075 0.0089
Echinococcus granulosus g protein coupled receptor 0.0075 0.0075 0.0089
Echinococcus granulosus serotonin receptor 0.0075 0.0075 0.0089
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0028 0.0018 0.0021
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0023 0.0012 0.0065
Echinococcus granulosus peptide allatostatin:somatostatin 0.0075 0.0075 0.0089
Leishmania major basic transcription factor 3a, putative 0.0023 0.0012 0.0188
Schistosoma mansoni biogenic amine receptor 0.0075 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.0075 0.0075 0.0229
Echinococcus granulosus neuropeptides capa receptor 0.0075 0.0075 0.0089
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0263 0.0307 0.0646
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0098 0.0104 0.0104
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0045 0.0038 0.0744
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0048 0.0042 0.0088
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0028 0.0017 0.1153
Echinococcus granulosus nuclear factor of activated T cells 5 0.0051 0.0046 0.0055
Toxoplasma gondii NAC domain-containing protein 0.0023 0.0012 0.0181
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0263 0.0307 0.0361
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0062 0.0059 0.018
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0052 0.0047 0.0099
Echinococcus granulosus neuropeptide receptor 0.0075 0.0075 0.0089
Trichomonas vaginalis CMGC family protein kinase 0.0043 0.0036 0.3215
Toxoplasma gondii histone lysine methyltransferase SET1 0.0074 0.0074 0.1524
Brugia malayi nuclear receptor RXR 0.0124 0.0136 0.0286
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0018 0.0005 0.0006
Schistosoma mansoni sodium/chloride dependent transporter 0.0424 0.0505 0.0505
Echinococcus granulosus neuropeptide FF receptor 2 0.0075 0.0075 0.0089
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0075 0.0075 0.0159
Echinococcus multilocularis 0.0107 0.0115 0.0136
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0075 0.0075 0.0075
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0107 0.0115 0.0136
Loa Loa (eye worm) hypothetical protein 0.0124 0.0136 0.0412
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0075 0.0075 0.0075
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0107 0.0115 0.0115
Loa Loa (eye worm) intermediate filament protein 0.0054 0.005 0.0152
Schistosoma mansoni solute carrier family 12 electroneutral k-cl cotransporter 0.0029 0.0018 0.0018
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0043 0.0036 0.0702
Echinococcus multilocularis rhodopsin orphan GPCR 0.0075 0.0075 0.0089
Echinococcus granulosus GPCR family 2 0.002 0.0007 0.0008
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0018 0.0005 0.0011
Loa Loa (eye worm) hypothetical protein 0.0067 0.0065 0.0198
Echinococcus granulosus epidermal growth factor receptor 0.0106 0.0114 0.0134
Schistosoma mansoni amine GPCR 0.0075 0.0075 0.0075
Brugia malayi tailless protein 0.0124 0.0136 0.0286
Loa Loa (eye worm) hypothetical protein 0.0075 0.0075 0.0229
Trypanosoma brucei protein kinase, putative 0.0043 0.0036 0.0737
Echinococcus multilocularis rhodopsin orphan GPCR 0.0075 0.0075 0.0089
Loa Loa (eye worm) hypothetical protein 0.0025 0.0014 0.0043
Loa Loa (eye worm) hypothetical protein 0.0075 0.0075 0.0229
Loa Loa (eye worm) steroid hormone receptor 0.0263 0.0307 0.0931
Loa Loa (eye worm) hypothetical protein 0.0054 0.005 0.0152
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0005 0.0011
Toxoplasma gondii hypothetical protein 0.0394 0.0468 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0015
Loa Loa (eye worm) hypothetical protein 0.0263 0.0307 0.0931
Onchocerca volvulus 0.0075 0.0075 0.027
Brugia malayi hypothetical protein 0.0394 0.0468 0.0986
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0291 0.0342 0.0403
Loa Loa (eye worm) matrixin family protein 0.0087 0.009 0.0272
Schistosoma mansoni neuropeptide receptor 0.0075 0.0075 0.0075
Trypanosoma brucei Peptide deformylase 2 0.0045 0.0038 0.0779
Mycobacterium leprae PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) 0.0117 0.0127 1
Loa Loa (eye worm) hypothetical protein 0.0075 0.0075 0.0229
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0018 0.0005 0.0011
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0048 0.0042 0.0127
Schistosoma mansoni growth hormone secretagogue receptor 0.0075 0.0075 0.0075
Trypanosoma brucei Polypeptide deformylase 1 0.0045 0.0038 0.0779
Entamoeba histolytica hypothetical protein, conserved 0.0023 0.0012 0.4546
Trypanosoma cruzi transcription factor btf3, putative 0.0023 0.0012 0.0151
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0263 0.0307 0.1097
Loa Loa (eye worm) hypothetical protein 0.0023 0.0012 0.0035
Entamoeba histolytica serine carboxypeptidase (S28) family protein 0.0018 0.0005 0.0926
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0363 0.043 0.0507
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0263 0.0307 0.0361
Schistosoma mansoni RAR-like nuclear receptor 0.0263 0.0307 0.0307
Plasmodium vivax ataxin-2 like protein, putative 0.0021 0.0009 0.0198
Schistosoma mansoni neuropeptide F-like receptor 0.0075 0.0075 0.0075
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0075 0.0075 0.0089
Loa Loa (eye worm) hypothetical protein 0.0263 0.0307 0.0931
Echinococcus multilocularis G protein coupled receptor 139 0.0075 0.0075 0.0089
Loa Loa (eye worm) DR-78 0.0124 0.0136 0.0412
Schistosoma mansoni coup transcription factor 0.0263 0.0307 0.0307
Loa Loa (eye worm) hypothetical protein 0.0132 0.0145 0.044
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0015
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0263 0.0307 0.0931
Echinococcus multilocularis 0.0032 0.0023 0.0027
Echinococcus granulosus rhodopsin orphan GPCR 0.0075 0.0075 0.0089
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0018 0.0005 0.0011
Schistosoma mansoni P2X receptor subunit 0.0023 0.0011 0.0011
Onchocerca volvulus 0.0075 0.0075 0.027
Echinococcus multilocularis raf serine:threonine protein kinase 0.0263 0.0307 0.0362
Brugia malayi neuropeptide F receptor 0.0075 0.0075 0.0159
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0016 0.0003 0.0016
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0394 0.0468 0.0552
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0052 0.0047 0.0047
Echinococcus multilocularis survival motor neuron protein 1 0.0365 0.0432 0.051
Echinococcus granulosus serotonin transporter 0.2283 0.2795 0.3295
Echinococcus multilocularis ecdysone induced protein 78C 0.0263 0.0307 0.0361
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0075 0.0075 0.0159
Loa Loa (eye worm) TK/INSR protein kinase 0.0035 0.0027 0.0081
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0028 0.0018 0.0021
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0028 0.0018 0.0021
Mycobacterium ulcerans monoamine oxidase 0.0107 0.0115 0.0618
Plasmodium falciparum peptide deformylase 0.0117 0.0127 0.271
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.2283 0.2795 0.2795
Plasmodium vivax hypothetical protein, conserved 0.0023 0.0012 0.0245
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0043 0.0036 0.0702
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0023 0.0012 0.0683
Loa Loa (eye worm) hypothetical protein 0.0263 0.0307 0.0931
Loa Loa (eye worm) hypothetical protein 0.2283 0.2795 0.8487
Trypanosoma cruzi transcription factor btf3, putative 0.0023 0.0012 0.0151
Echinococcus multilocularis dnaJ subfamily B 0.0555 0.0667 0.0786
Brugia malayi MAP kinase sur-1 0.0043 0.0036 0.0076
Schistosoma mansoni alpha-1 adrenergic receptor 0.0075 0.0075 0.0075
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0263 0.0307 0.0361
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0424 0.0505 0.1533
Schistosoma mansoni hypothetical protein 0.0048 0.0042 0.0042
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0107 0.0115 0.2463
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0263 0.0307 0.0307
Onchocerca volvulus Neuropeptide F receptor homolog 0.0075 0.0075 0.027
Loa Loa (eye worm) hypothetical protein 0.0139 0.0154 0.0467
Schistosoma mansoni neuropeptide F-like receptor 0.0075 0.0075 0.0075
Echinococcus multilocularis rhodopsin orphan GPCR 0.0075 0.0075 0.0089
Trypanosoma cruzi UDP-galactopyranose mutase 0.0107 0.0115 0.2486
Brugia malayi Serotonin receptor 0.3867 0.4746 1
Echinococcus multilocularis g protein coupled receptor 0.0075 0.0075 0.0089
Entamoeba histolytica transcription factor BTF3, putative 0.0023 0.0012 0.4589
Loa Loa (eye worm) TK protein kinase 0.0023 0.0011 0.0034
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0075 0.0075 0.0075
Echinococcus granulosus glycine receptor subunit alpha 1 0.0018 0.0005 0.0006
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0107 0.0115 0.0618
Brugia malayi intermediate filament protein 0.0054 0.005 0.0106
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0394 0.0468 1
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0291 0.0342 0.0403
Echinococcus granulosus dnaJ subfamily B 0.0555 0.0667 0.0786
Brugia malayi hypothetical protein 0.0365 0.0432 0.0911
Entamoeba histolytica prolyl oligopeptidase family protein 0.0023 0.0012 0.4546
Brugia malayi hypothetical protein 0.0075 0.0075 0.0159
Brugia malayi follicle stimulating hormone receptor 0.0582 0.07 0.1476
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0028 0.0018 0.0021
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0075 0.0075 0.0075
Brugia malayi GnHR receptor homolog 0.0075 0.0075 0.0159
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0012 0.0683
Loa Loa (eye worm) hypothetical protein 0.0024 0.0013 0.004
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0023 0.0012 0.4546
Loa Loa (eye worm) hypothetical protein 0.0029 0.0018 0.0055
Echinococcus multilocularis neuropeptide FF receptor 2 0.0075 0.0075 0.0089
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0015
Loa Loa (eye worm) hypothetical protein 0.2688 0.3293 1
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0048 0.0042 0.0239
Loa Loa (eye worm) hypothetical protein 0.2688 0.3293 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0263 0.0307 0.0361
Loa Loa (eye worm) fli-1 protein 0.0145 0.0161 0.049
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0023 0.0012 0.0011
Echinococcus multilocularis rhodopsin orphan GPCR 0.0075 0.0075 0.0089
Plasmodium vivax hypothetical protein, conserved 0.0394 0.0468 1
Loa Loa (eye worm) integrin beta-2 0.0141 0.0156 0.0475
Plasmodium vivax amine transporter, putative 0.0394 0.0468 1
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0394 0.0468 1
Onchocerca volvulus Huntingtin homolog 0.0067 0.0065 0.0234
Trypanosoma brucei C-8 sterol isomerase, putative 0.0378 0.0449 1
Schistosoma mansoni biogenic amine receptor 0.0075 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.0107 0.0115 0.035
Loa Loa (eye worm) hypothetical protein 0.0075 0.0075 0.0229
Loa Loa (eye worm) hypothetical protein 0.0052 0.0047 0.0142
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.002 0.0007 0.0008
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0015
Brugia malayi Cation transporter family protein 0.0052 0.0047 0.0099
Echinococcus granulosus g protein coupled receptor 0.0075 0.0075 0.0089
Brugia malayi Matrixin family protein 0.0039 0.0031 0.0066
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0124 0.0136 0.016
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0075 0.0075 0.0075
Schistosoma mansoni opsin-like receptor 0.0075 0.0075 0.0075
Entamoeba histolytica prolyl oligopeptidase family protein 0.0023 0.0012 0.4546
Echinococcus multilocularis p2X purinoceptor 4 0.0023 0.0011 0.0013
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0124 0.0136 0.0286
Onchocerca volvulus 0.0054 0.005 0.0179
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0124 0.0136 0.016
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0155 0.0174 0.3728
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0043 0.0036 0.0702
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0015
Trypanosoma cruzi cytochrome P450, putative 0.0018 0.0006 0.0021
Loa Loa (eye worm) serotonin transporter b 0.2283 0.2795 0.8487
Brugia malayi Nuclear hormone receptor-like 1 0.0139 0.0154 0.0324
Loa Loa (eye worm) hypothetical protein 0.0394 0.0468 0.1421
Loa Loa (eye worm) hypothetical protein 0.0075 0.0075 0.0229
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0015
Brugia malayi hypothetical protein 0.0139 0.0154 0.0324
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0022 0.001 0.0031
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0019 0.0058
Loa Loa (eye worm) cytochrome P450 family protein 0.0018 0.0006 0.0018
Brugia malayi SRC-1 0.0028 0.0018 0.0037
Onchocerca volvulus 0.0035 0.0026 0.0092
Toxoplasma gondii hypothetical protein 0.0023 0.0012 0.0179
Brugia malayi hypothetical protein 0.0075 0.0075 0.0159
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0012 0.0691
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0043 0.0036 0.0702
Trypanosoma brucei prolyl oligopeptidase, putative 0.0023 0.0012 0.0187
Onchocerca volvulus 0.0075 0.0075 0.027
Brugia malayi ecdysone receptor 0.0124 0.0136 0.0286
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0098 0.0104 0.2255
Brugia malayi PAS domain containing protein 0.0034 0.0025 0.0053
Loa Loa (eye worm) hypothetical protein 0.0052 0.0047 0.0142
Brugia malayi Melatonin receptor type 1A 0.0075 0.0075 0.0159
Echinococcus granulosus 7tm_1 domain containing protein 0.0075 0.0075 0.0089
Echinococcus granulosus biogenic amine 5HT receptor 0.016 0.018 0.0212
Schistosoma mansoni zinc finger protein 0.0124 0.0136 0.0136
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0107 0.0115 0.9064
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0031 0.0021 0.0114
Brugia malayi prolyl oligopeptidase family protein 0.0291 0.0342 0.072
Brugia malayi hypothetical protein 0.0075 0.0075 0.0159
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0263 0.0307 0.0646
Toxoplasma gondii hypothetical protein 0.0117 0.0127 0.2661
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0582 0.07 0.2126
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0018 0.0005 0.0005
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0124 0.0136 0.016
Loa Loa (eye worm) hypothetical protein 0.0075 0.0075 0.0229
Echinococcus granulosus glycine receptor subunit alpha 1 0.0018 0.0005 0.0006
Leishmania major cytochrome p450-like protein 0.0018 0.0006 0.0059
Schistosoma mansoni lamin 0.0054 0.005 0.005
Echinococcus granulosus g-protein coupled receptor 0.0075 0.0075 0.0089
Toxoplasma gondii histone lysine-specific demethylase 0.0107 0.0115 0.2412
Loa Loa (eye worm) hypothetical protein 0.016 0.018 0.0547
Brugia malayi prolyl oligopeptidase family protein 0.0023 0.0012 0.0024
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0075 0.0075 0.0089
Echinococcus granulosus glycine receptor subunit beta 0.0018 0.0005 0.0006
Echinococcus multilocularis orexin receptor type 2 0.0075 0.0075 0.0089
Loa Loa (eye worm) hypothetical protein 0.0024 0.0013 0.004
Loa Loa (eye worm) latrophilin receptor protein 2 0.002 0.0007 0.0022
Onchocerca volvulus 0.0075 0.0075 0.027
Echinococcus multilocularis neuropeptides capa receptor 0.0075 0.0075 0.0089
Echinococcus granulosus rhodopsin orphan GPCR 0.0075 0.0075 0.0089
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0124 0.0136 0.016
Onchocerca volvulus Putative nachr subunit 0.0052 0.0047 0.0167
Loa Loa (eye worm) hypothetical protein 0.0139 0.0154 0.0467
Trichomonas vaginalis CMGC family protein kinase 0.0043 0.0036 0.3215
Brugia malayi NNMT/PNMT/TEMT family protein 0.2688 0.3293 0.694
Chlamydia trachomatis peptide deformylase 0.0117 0.0127 0.2706
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0082 0.0085 0.01
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0075 0.0075 0.0229
Echinococcus granulosus neuropeptide receptor A26 0.0396 0.0471 0.0556
Echinococcus granulosus p2X purinoceptor 4 0.0023 0.0011 0.0013
Echinococcus multilocularis lamin 0.0054 0.005 0.0059
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0107 0.0115 0.2463
Trichomonas vaginalis CMGC family protein kinase 0.0043 0.0036 0.3215
Leishmania major polypeptide deformylase-like protein, putative 0.0045 0.0038 0.0779
Loa Loa (eye worm) hypothetical protein 0.0075 0.0075 0.0229
Loa Loa (eye worm) hypothetical protein 0.0075 0.0075 0.0228
Giardia lamblia Kinase, CMGC MAPK 0.0043 0.0036 0.1838
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0075 0.0075 0.0075
Echinococcus granulosus tm gpcr rhodopsin 0.0075 0.0075 0.0089
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0263 0.0307 0.0646
Loa Loa (eye worm) hypothetical protein 0.0364 0.0432 0.1311
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0012 0.0149
Schistosoma mansoni cpg binding protein 0.0041 0.0034 0.0034
Brugia malayi larval opioid receptor 0.0075 0.0075 0.0159
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0124 0.0136 0.016
Schistosoma mansoni inositol monophosphatase 0.0031 0.0021 0.0021
Echinococcus granulosus Nuclear hormone receptor HR96 0.0124 0.0136 0.016
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.002 0.0007 0.0008
Echinococcus granulosus alpha 1A adrenergic receptor 0.0075 0.0075 0.0089
Echinococcus granulosus neuropeptide s receptor 0.0396 0.0471 0.0556
Loa Loa (eye worm) hypothetical protein 0.0048 0.0042 0.0126
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0015
Loa Loa (eye worm) hypothetical protein 0.0024 0.0013 0.004
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0018 0.0005 0.0006
Loa Loa (eye worm) hypothetical protein 0.0075 0.0075 0.0229
Schistosoma mansoni hypothetical protein 0.0118 0.0129 0.0129
Loa Loa (eye worm) hypothetical protein 0.0024 0.0013 0.004
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0394 0.0468 0.0552
Loa Loa (eye worm) hypothetical protein 0.0124 0.0136 0.0412
Onchocerca volvulus 0.0052 0.0047 0.0167
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0098 0.0104 0.2255
Echinococcus multilocularis p2X purinoceptor 4 0.0023 0.0011 0.0013
Onchocerca volvulus 0.0075 0.0075 0.027
Loa Loa (eye worm) hypothetical protein 0.0062 0.0059 0.018
Plasmodium falciparum amino acid transporter, putative 0.0394 0.0468 1
Loa Loa (eye worm) hypothetical protein 0.0075 0.0075 0.0229
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0018 0.0005 0.0006
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0075 0.0075 0.0075
Schistosoma mansoni hypothetical protein 0.0075 0.0075 0.0075
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0028 0.0018 0.0021
Echinococcus multilocularis p2X purinoceptor 4 0.0023 0.0011 0.0013
Echinococcus multilocularis G-protein coupled receptor, putative 0.0075 0.0075 0.0089
Brugia malayi Serine protease Z688.6 precursor 0.0018 0.0005 0.001
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0005 0.0011
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0075 0.0075 0.0229
Echinococcus multilocularis Lysosomal Pro X carboxypeptidase 0.033 0.0389 0.0459
Echinococcus granulosus p2X purinoceptor 4 0.0023 0.0011 0.0013
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0394 0.0468 0.0468
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.002 0.0007 0.0008
Brugia malayi Nuclear hormone receptor E75 0.0124 0.0136 0.0286
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0394 0.0468 1
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0052 0.0047 0.0055
Schistosoma mansoni hypothetical protein 0.002 0.0007 0.0007
Plasmodium vivax peptide deformylase, putative 0.0117 0.0127 0.271
Loa Loa (eye worm) hypothetical protein 0.0039 0.0031 0.0094
Loa Loa (eye worm) hypothetical protein 0.0041 0.0033 0.0101
Brugia malayi SWIRM domain containing protein 0.0107 0.0115 0.0243
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0098 0.0104 0.2226
Loa Loa (eye worm) hypoxia-induced factor 1 0.0105 0.0113 0.0342
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0028 0.0018 0.0021
Entamoeba histolytica serine carboxypeptidase (S28) family protein 0.0018 0.0005 0.0926
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0107 0.0115 0.2463
Echinococcus multilocularis glycine receptor subunit beta 0.0018 0.0005 0.0006
Plasmodium falciparum transporter, putative 0.0394 0.0468 1
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0023 0.0012 0.0672
Schistosoma mansoni integrin beta subunit 0.0081 0.0083 0.0083
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0018 0.0005 0.0006
Echinococcus multilocularis somatostatin receptor 0.0075 0.0075 0.0089
Echinococcus granulosus neuropeptides capa receptor 0.0075 0.0075 0.0089
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0139 0.0154 0.0181
Loa Loa (eye worm) hypothetical protein 0.0124 0.0136 0.0412
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0075 0.0075 0.0075
Echinococcus granulosus jun protein 0.0059 0.0055 0.0065
Loa Loa (eye worm) hypothetical protein 0.0124 0.0136 0.0412
Loa Loa (eye worm) hypothetical protein 0.0263 0.0307 0.0931
Loa Loa (eye worm) prolyl oligopeptidase 0.0291 0.0342 0.1038
Echinococcus granulosus integrin beta 2 0.0103 0.011 0.013
Entamoeba histolytica prolyl oligopeptidase family protein 0.0023 0.0012 0.4546
Mycobacterium ulcerans aldehyde dehydrogenase 0.0094 0.0098 0.0528
Brugia malayi nuclear receptor RXR 0.0139 0.0154 0.0324
Onchocerca volvulus 0.0124 0.0136 0.0485
Schistosoma mansoni nuclear hormone receptor 0.0263 0.0307 0.0307
Wolbachia endosymbiont of Brugia malayi peptide deformylase 0.0117 0.0127 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0124 0.0136 0.0485
Brugia malayi AKH receptor 0.0075 0.0075 0.0159
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0263 0.0307 0.0931
Brugia malayi Nuclear hormone receptor E75 0.0124 0.0136 0.0286
Loa Loa (eye worm) hypothetical protein 0.0075 0.0075 0.0229
Echinococcus granulosus hypothetical protein 0.0557 0.0669 0.0789
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0155 0.0174 0.3728
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0018 0.0005 0.0015
Schistosoma mansoni nAChR subunit 0.0018 0.0005 0.0005
Echinococcus multilocularis integrin beta 2 0.0103 0.011 0.013
Onchocerca volvulus 0.0075 0.0075 0.027
Trypanosoma cruzi PAB1-binding protein , putative 0.0021 0.0009 0.0099
Brugia malayi hypothetical protein 0.0075 0.0075 0.0159
Brugia malayi Nuclear hormone receptor-like 1 0.0263 0.0307 0.0646
Loa Loa (eye worm) hypothetical protein 0.0024 0.0013 0.004
Echinococcus granulosus tumor protein p63 0.0236 0.0274 0.0323
Brugia malayi Raf kinase 0.0254 0.0296 0.0623
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0155 0.0174 0.3728
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0018 0.0005 0.0011
Brugia malayi Dopamine receptor 0.0075 0.0075 0.0159
Echinococcus granulosus glycine receptor subunit beta 0.0018 0.0005 0.0006
Loa Loa (eye worm) cytochrome P450 family protein 0.0039 0.0031 0.0094
Brugia malayi ecdysteroid receptor 0.0263 0.0307 0.0646
Loa Loa (eye worm) hypothetical protein 0.0124 0.0136 0.0412
Onchocerca volvulus 0.0018 0.0005 0.0018
Schistosoma mansoni nAChR subunit 0.0018 0.0005 0.0005
Onchocerca volvulus 0.0394 0.0468 0.1674
Loa Loa (eye worm) neuropeptide F receptor 0.0075 0.0075 0.0229
Schistosoma mansoni jun-related protein 0.0048 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0067 0.0065 0.0198
Echinococcus granulosus tyrosine kinase 0.0026 0.0015 0.0017
Loa Loa (eye worm) hypothetical protein 0.0075 0.0075 0.0229
Onchocerca volvulus 0.0075 0.0075 0.027
Brugia malayi Protein kinase domain containing protein 0.0035 0.0027 0.0056
Toxoplasma gondii cathepsin CPC2 0.0059 0.0056 0.113
Toxoplasma gondii cathepsin CPC1 0.0155 0.0174 0.3686
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0005 0.0011
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0018 0.0005 0.0011
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0023 0.0012 0.0149
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0075 0.0075 0.0089
Echinococcus multilocularis sex peptide receptor 0.0075 0.0075 0.0089
Treponema pallidum sodium- and chloride- dependent transporter 0.2283 0.2795 1
Brugia malayi G protein-coupled receptor F59B2.13 0.0075 0.0075 0.0159
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0023 0.0012 0.006
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.1524 0.186 1
Echinococcus granulosus fmrfamide receptor 0.0075 0.0075 0.0089
Schistosoma mansoni tyrosine kinase 0.0055 0.0051 0.0051
Trypanosoma cruzi Peptide deformylase 2, putative 0.0045 0.0038 0.0744
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0018 0.0005 0.0006
Echinococcus multilocularis epidermal growth factor receptor 0.0106 0.0114 0.0134
Loa Loa (eye worm) hypothetical protein 0.0075 0.0075 0.0229
Brugia malayi Cytochrome P450 family protein 0.0018 0.0006 0.0012
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0058 0.0055 0.0055
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0023 0.0012 0.0187
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0052 0.0047 0.0055
Onchocerca volvulus Matrilysin homolog 0.0087 0.009 0.0321
Echinococcus granulosus tyrosine protein kinase Src42A 0.0028 0.0018 0.0021
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0059 0.0055 0.0065
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0075 0.0075 0.0159
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0074 0.0075 0.0157
Echinococcus multilocularis nmda type glutamate receptor 0.0019 0.0007 0.0008
Brugia malayi Fli-1 protein 0.0145 0.0161 0.034
Schistosoma mansoni cpg binding protein 0.0039 0.0031 0.0031
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0263 0.0307 0.0646
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0052 0.0047 0.0142
Echinococcus granulosus nmda type glutamate receptor 0.0019 0.0007 0.0008
Echinococcus granulosus dro:myosuppressin receptor 0.0075 0.0075 0.0089
Echinococcus granulosus tyrosine protein kinase HCK 0.0023 0.0011 0.0013
Echinococcus granulosus neuropeptide Y receptor 0.0075 0.0075 0.0089
Brugia malayi hypothetical protein 0.0075 0.0075 0.0159
Loa Loa (eye worm) hypothetical protein 0.0039 0.0031 0.0094
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0031 0.0021 0.0393
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0394 0.0468 0.0468
Brugia malayi nuclear receptor NHR-88 0.0124 0.0136 0.0286
Loa Loa (eye worm) hypothetical protein 0.0394 0.0468 0.1421
Mycobacterium ulcerans aldehyde dehydrogenase 0.0094 0.0098 0.0528
Loa Loa (eye worm) hypothetical protein 0.0021 0.0009 0.0028
Plasmodium falciparum ataxin-2 like protein, putative 0.0021 0.0009 0.0198
Leishmania major oligopeptidase b 0.0023 0.0012 0.0187
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0098 0.0104 0.0122
Brugia malayi nuclear receptor NHR-67 0.0124 0.0136 0.0286
Loa Loa (eye worm) cytochrome P450 family protein 0.0018 0.0006 0.0018
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0075 0.0075 0.0075
Echinococcus granulosus tachykinin peptides receptor 99D 0.0075 0.0075 0.0089
Brugia malayi hypothetical protein 0.0067 0.0065 0.0138
Loa Loa (eye worm) hypothetical protein 0.0107 0.0115 0.035
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0075 0.0075 0.0075
Schistosoma mansoni histamine h1 receptor 0.0075 0.0075 0.0075
Onchocerca volvulus 0.0052 0.0047 0.0167
Echinococcus multilocularis musashi 0.0054 0.005 0.0059
Loa Loa (eye worm) hypothetical protein 0.0042 0.0035 0.0107
Schistosoma mansoni hypothetical protein 0.0075 0.0075 0.0075
Trypanosoma cruzi prolyl endopeptidase 0.0023 0.0012 0.0149
Brugia malayi Cytochrome P450 family protein 0.0039 0.0031 0.0066
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0018 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0075 0.0075 0.0229
Brugia malayi bZIP transcription factor family protein 0.0059 0.0055 0.0117
Brugia malayi Hypothetical 112.3 kDa protein K02A2.3 in chromosome II 0.0029 0.0018 0.0038
Echinococcus multilocularis tyrosine protein kinase Blk 0.0026 0.0015 0.0017
Echinococcus multilocularis fmrfamide receptor 0.0075 0.0075 0.0089
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0075 0.0075 0.0089
Echinococcus granulosus solute carrier family 12 0.0029 0.0018 0.0021
Onchocerca volvulus 0.0075 0.0075 0.027
Loa Loa (eye worm) hypothetical protein 0.0139 0.0154 0.0467
Schistosoma mansoni single-minded 0.0034 0.0025 0.0025
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0098 0.0104 0.2255
Loa Loa (eye worm) hypothetical protein 0.0075 0.0075 0.0229
Loa Loa (eye worm) hypothetical protein 0.0124 0.0136 0.0412
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0075 0.0075 0.0075
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0016 0.0003 0.001
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0028 0.0018 0.0021
Echinococcus multilocularis tyrosine protein kinase HCK 0.0023 0.0011 0.0013
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0075 0.0075 0.0089
Loa Loa (eye worm) hypothetical protein 0.0124 0.0136 0.0412
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0263 0.0307 0.0646
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0263 0.0307 0.0646
Loa Loa (eye worm) hypothetical protein 0.0424 0.0505 0.1533
Loa Loa (eye worm) hypothetical protein 0.0029 0.0018 0.0055
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0012 0.0149
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0394 0.0468 0.0468
Echinococcus granulosus tyrosine protein kinase Fyn 0.0028 0.0018 0.0021
Schistosoma mansoni serine/threonine protein kinase 0.0263 0.0307 0.0307
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0075 0.0075 0.0229
Echinococcus multilocularis conserved hypothetical protein 0.0482 0.0577 0.068
Onchocerca volvulus 0.0394 0.0468 0.1674
Schistosoma mansoni amine oxidase 0.0107 0.0115 0.0115
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0075 0.0075 0.0089
Brugia malayi RE15519p 0.0075 0.0075 0.0159
Loa Loa (eye worm) hypothetical protein 0.0029 0.0018 0.0055
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0263 0.0307 0.0361
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0016 0.0003 0.0016
Onchocerca volvulus Prolyl endopeptidase homolog 0.0023 0.0012 0.0041
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0075 0.0075 0.0089
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0394 0.0468 0.0552
Echinococcus granulosus sex peptide receptor 0.0075 0.0075 0.0089
Echinococcus granulosus sodium and chloride dependent glycine 0.0424 0.0505 0.0595
Brugia malayi putative neuropeptide receptor NPR1 0.0075 0.0075 0.0159
Echinococcus multilocularis serotonin receptor 0.016 0.018 0.0212
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0394 0.0468 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0263 0.0307 0.1097
Schistosoma mansoni neuropeptide receptor 0.0075 0.0075 0.0075
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0263 0.0307 0.0361
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0016 0.0003 0.0017
Echinococcus multilocularis X box binding protein 1 0.0201 0.0231 0.0272
Onchocerca volvulus 0.0054 0.005 0.0179
Loa Loa (eye worm) hypothetical protein 0.0075 0.0075 0.0229
Schistosoma mansoni nAChR subunit 0.0018 0.0005 0.0005
Trypanosoma cruzi oligopeptidase b 0.0023 0.0012 0.0149
Echinococcus multilocularis inositol monophosphatase 1 0.0031 0.0021 0.0025
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0018 0.0005 0.0006
Brugia malayi Cytochrome P450 family protein 0.0018 0.0006 0.0012
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0124 0.0136 0.0136
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0075 0.0075 0.0089
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0015
Schistosoma mansoni tyrosine kinase 0.0035 0.0027 0.0027
Echinococcus multilocularis solute carrier family 12 0.0029 0.0018 0.0021
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0263 0.0307 0.0307
Brugia malayi Calcitonin receptor-like protein seb-1 0.0062 0.0059 0.0125
Mycobacterium ulcerans oxidoreductase 0.0107 0.0115 0.0618
Brugia malayi Kelch motif family protein 0.0022 0.001 0.0022
Echinococcus granulosus glycine receptor subunit alpha 1 0.0018 0.0005 0.0006
Echinococcus multilocularis prolyl endopeptidase 0.0023 0.0012 0.0014
Echinococcus multilocularis nuclear receptor nhr 48 0.0124 0.0136 0.016
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0018 0.0005 0.0006
Echinococcus granulosus orexin receptor type 2 0.0075 0.0075 0.0089
Brugia malayi Nuclear hormone receptor-like 1 0.0139 0.0154 0.0324
Echinococcus granulosus FTZ F1 alpha 0.0263 0.0307 0.0361
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0015
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0394 0.0468 0.0986
Schistosoma mansoni myosin xvIII 0.0075 0.0075 0.0075
Onchocerca volvulus 0.0075 0.0075 0.027
Loa Loa (eye worm) hypothetical protein 0.0035 0.0026 0.0078
Toxoplasma gondii prolyl endopeptidase 0.0023 0.0012 0.0179
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0082 0.0085 0.01
Schistosoma mansoni nAChR subunit 0.0018 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0015
Schistosoma mansoni tyrosine kinase 0.0028 0.0018 0.0018
Schistosoma mansoni inositol monophosphatase 0.0031 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0015
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0052 0.0047 0.0055
Loa Loa (eye worm) hypothetical protein 0.0075 0.0075 0.0229
Echinococcus granulosus rhodopsin orphan GPCR 0.0075 0.0075 0.0089
Echinococcus multilocularis GPCR, family 2 0.002 0.0007 0.0008
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0155 0.0174 0.0174
Brugia malayi hypothetical protein 0.0107 0.0115 0.0243
Loa Loa (eye worm) hypothetical protein 0.0039 0.0031 0.0094
Toxoplasma gondii LsmAD domain-containing protein 0.0021 0.0009 0.0131
Schistosoma mansoni hypothetical protein 0.0075 0.0075 0.0075
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.015 0.0167 0.0508
Brugia malayi Tachykinin-like peptides receptor 99D 0.0075 0.0075 0.0159
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0031 0.0021 0.041
Schistosoma mansoni cellular tumor antigen P53 0.0035 0.0026 0.0026
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0107 0.0115 0.0115
Trypanosoma brucei PAB1-binding protein , putative 0.0021 0.0009 0.0137
Trypanosoma brucei cytochrome P450, putative 0.0018 0.0006 0.0059
Brugia malayi orphan nuclear receptor NR2E1 0.0124 0.0136 0.0286
Echinococcus granulosus sodium and chloride dependent glycine 0.0424 0.0505 0.0595
Schistosoma mansoni nAChR subunit 0.0018 0.0005 0.0005
Echinococcus granulosus single minded 2 0.0025 0.0014 0.0017
Echinococcus multilocularis g protein coupled receptor 0.0075 0.0075 0.0089
Echinococcus granulosus mitogen activated protein kinase 0.0043 0.0036 0.0042
Loa Loa (eye worm) TK/EGFR protein kinase 0.0106 0.0114 0.0346
Brugia malayi nuclear receptor NHR-88 0.0263 0.0307 0.0646
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0028 0.0018 0.0021
Echinococcus multilocularis sodium and chloride dependent glycine 0.0424 0.0505 0.0595
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.002 0.0007 0.0008
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0043 0.0036 0.0737
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0028 0.0017 0.0099
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0075 0.0075 0.0089
Loa Loa (eye worm) hypothetical protein 0.0075 0.0075 0.0229
Schistosoma mansoni nuclear receptor 0.0124 0.0136 0.0136
Loa Loa (eye worm) hypothetical protein 0.0263 0.0307 0.0931
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0075 0.0075 0.0075
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0054 0.005 0.0152
Brugia malayi CXXC zinc finger family protein 0.0039 0.0031 0.0066
Loa Loa (eye worm) hypothetical protein 0.2283 0.2795 0.8487
Echinococcus granulosus survival motor neuron protein 1 0.0365 0.0432 0.051
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0058 0.0055 0.0115
Echinococcus multilocularis sodium and chloride dependent glycine 0.0424 0.0505 0.0595
Schistosoma mansoni tyrosine kinase 0.0028 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0075 0.0075 0.0229
Onchocerca volvulus 0.0075 0.0075 0.027
Giardia lamblia Alanyl dipeptidyl peptidase 0.0023 0.0012 0.039
Mycobacterium ulcerans hydrolase 0.0048 0.0042 0.0222
Onchocerca volvulus Bile acid receptor homolog 0.0263 0.0307 0.1097
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0031 0.0021 0.041
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0035 0.0027 0.0031
Echinococcus granulosus tm gpcr rhodopsin 0.69 0.8482 1
Mycobacterium ulcerans peptide deformylase 0.0117 0.0127 0.068
Onchocerca volvulus Matrilysin homolog 0.0039 0.0031 0.0111
Brugia malayi Ets-domain containing protein 0.0048 0.0042 0.0088
Loa Loa (eye worm) hypothetical protein 0.0263 0.0307 0.0931
Chlamydia trachomatis protoporphyrinogen oxidase 0.0107 0.0115 0.2459
Loa Loa (eye worm) hypothetical protein 0.0365 0.0432 0.1313
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0139 0.0154 0.0181
Echinococcus granulosus allatostatin A receptor 0.0075 0.0075 0.0089
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0263 0.0307 0.0931
Schistosoma mansoni family S28 unassigned peptidase (S28 family) 0.033 0.0389 0.0389
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0023 0.0012 0.0149
Giardia lamblia Alanyl dipeptidyl peptidase 0.0023 0.0012 0.039
Loa Loa (eye worm) hypothetical protein 0.0124 0.0136 0.0412
Schistosoma mansoni nuclear hormone receptor 0.0124 0.0136 0.0136
Schistosoma mansoni lamin 0.0054 0.005 0.005
Brugia malayi G-protein coupled receptor 0.0075 0.0075 0.0159
Echinococcus multilocularis rhodopsin orphan GPCR 0.0075 0.0075 0.0089
Echinococcus granulosus neuropeptide receptor 0.0075 0.0075 0.0089
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0016 0.0003 0.0062
Leishmania major UDP-galactopyranose mutase 0.0107 0.0115 0.2515
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0263 0.0307 0.0361
Loa Loa (eye worm) hypothetical protein 0.0107 0.0115 0.035
Echinococcus granulosus L aminoadipate semialdehyde 0.0058 0.0055 0.0064
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0075 0.0075 0.0229
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0263 0.0307 0.0361
Plasmodium vivax hypothetical protein, conserved 0.0107 0.0115 0.2463
Schistosoma mansoni adenoreceptor 0.0075 0.0075 0.0075
Brugia malayi Matrixin family protein 0.0039 0.0031 0.0066
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0018 0.0005 0.0015
Echinococcus granulosus acylamino acid releasing enzyme 0.0023 0.0012 0.0014
Onchocerca volvulus 0.0075 0.0075 0.027
Onchocerca volvulus 0.0037 0.0029 0.0104
Toxoplasma gondii hypothetical protein 0.0394 0.0468 1
Echinococcus multilocularis epidermal growth factor receptor 0.0058 0.0055 0.0064
Echinococcus multilocularis neuropeptides capa receptor 0.0075 0.0075 0.0089
Loa Loa (eye worm) G-protein coupled receptor 0.0075 0.0075 0.0229
Loa Loa (eye worm) prolyl oligopeptidase 0.0023 0.0012 0.0035
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0031 0.0021 0.1711
Brugia malayi hypothetical protein 0.0075 0.0075 0.0159
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0028 0.0018 0.0021
Echinococcus granulosus Lysosomal Pro X carboxypeptidase 0.033 0.0389 0.0459
Brugia malayi Matrixin family protein 0.0039 0.0031 0.0066
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0022
Loa Loa (eye worm) hypothetical protein 0.016 0.018 0.0547
Schistosoma mansoni amine GPCR 0.0191 0.0218 0.0218
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0018 0.0005 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0263 0.0307 0.0646
Echinococcus granulosus G protein coupled receptor 139 0.0075 0.0075 0.0089
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0394 0.0468 0.0468
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0018 0.0005 0.0006
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.1417 0.1728 1
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0023 0.0012 0.0011
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0172 0.0196 0.0195
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0394 0.0468 0.0552
Echinococcus granulosus neuropeptide Y receptor 0.0075 0.0075 0.0089
Echinococcus multilocularis geminin 0.0118 0.0129 0.0152
Loa Loa (eye worm) hypothetical protein 0.0075 0.0075 0.0229
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0075 0.0075 0.0089
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0035 0.0027 0.0031
Echinococcus multilocularis lamin dm0 0.0054 0.005 0.0059
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.69 0.8482 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0015
Schistosoma mansoni sodium/chloride dependent transporter 0.2283 0.2795 0.2795
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0031 0.0021 0.0374
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0263 0.0307 0.0307
Loa Loa (eye worm) hypothetical protein 0.0029 0.0018 0.0055
Schistosoma mansoni amine GPCR 0.0075 0.0075 0.0075
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0023 0.0012 0.0187
Toxoplasma gondii preprocathepsin c precursor, putative 0.0155 0.0174 0.3686
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0263 0.0307 0.0931
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0043 0.0036 0.0737
Onchocerca volvulus Matrix metalloproteinase homolog 0.0087 0.009 0.0321
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0291 0.0342 0.1223
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0094 0.0098 0.0116
Loa Loa (eye worm) hypothetical protein 0.0107 0.0115 0.035
Schistosoma mansoni biogenic amine receptor 0.0075 0.0075 0.0075
Schistosoma mansoni hypothetical protein 0.002 0.0007 0.0007
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0075 0.0075 0.0089
Echinococcus granulosus lysine specific histone demethylase 1A 0.0107 0.0115 0.0136
Loa Loa (eye worm) hypothetical protein 0.0263 0.0307 0.0931
Echinococcus granulosus lysine specific histone demethylase 1A 0.0107 0.0115 0.0136
Loa Loa (eye worm) hypothetical protein 0.0075 0.0075 0.0229
Echinococcus granulosus tyrosine protein kinase Fyn 0.0028 0.0018 0.0021
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0263 0.0307 0.0361
Loa Loa (eye worm) hypothetical protein 0.0394 0.0468 0.1421
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0059 0.0056 0.1189
Brugia malayi nuclear hormone receptor 0.0124 0.0136 0.0286
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0083 0.0085 0.0085
Schistosoma mansoni transcription factor btf3 0.0023 0.0012 0.0012
Onchocerca volvulus 0.0018 0.0005 0.0018
Echinococcus granulosus X box binding protein 1 0.0201 0.0231 0.0272
Echinococcus granulosus inositol monophosphatase 1 0.0031 0.0021 0.0025
Loa Loa (eye worm) hypothetical protein 0.0029 0.0018 0.0055
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0023 0.0012 0.0011
Brugia malayi Serotonin receptor 0.0075 0.0075 0.0159
Echinococcus granulosus GA binding protein alpha chain 0.0048 0.0042 0.0049
Loa Loa (eye worm) hypothetical protein 0.0075 0.0075 0.0229
Echinococcus multilocularis FTZ F1 alpha 0.0263 0.0307 0.0361
Brugia malayi steroid hormone receptor 0.0263 0.0307 0.0646
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0124 0.0136 0.016
Giardia lamblia Encystation-specific protease 0.0059 0.0056 0.2996
Echinococcus granulosus geminin 0.0118 0.0129 0.0152
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0028 0.0018 0.0021

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 3 nM BindingDB_Patents: kinase Assay. The final concentration of DMSO is 5%. 10 µL of the B-Raf (V600E)-kinase solution are pipetted in (containing 0.5 ng B-Raf (V600E)-kinase in 20 mM Tris-HCl pH 7.5, 0.1 mM EDTA, 0.1 mM EGTA, 0.286 mM sodium orthovanadate, 10% glycerol, 1 mg/mL bovine serum albumin, 1 mM dithiothreitol) and the mixture is incubated for 24 h at RT under with shaking. The kinase reaction is started by the addition of 20 µL ATP solution [final concentration: 250 µM ATP, 30 mM Tris-HCl pH 7.5, 0.02% Brij, 0.2 mM sodium orthovanadate, 10 mM magnesium acetate, 0.1 mM EGTA, phosphatase cocktail (Sigma, # P2850, dilution recommended by the manufacturer), 0.1 mM EGTA] and 10 µL MEK1 solution [containing 50 ng biotinylated MEK1 (prepared from purified MEK1 according to standard procedure, e.g. with EZ-Link Sulpho-NHS-LC-Biotin reagent, Pierce, #21335) and carried out for 60 min at RT with constant shaking. ChEMBL. No reference
IC50 (binding) = 3 nM kinase Assay BINDINGDB. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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