Detailed information for compound 257863

Basic information

Technical information
  • TDR Targets ID: 257863
  • Name: 2-Thiophenecarboxylic acid, 2-[(7R)-3a-carbox y-4-formyl-3a,4,4a,5,6,7,7a,8-octahydro-7-met hyl-3-(1-methylethyl)-1,4-methano-s-indacen-8 a(1H)-yl]ethyl ester
  • MW: 456.594 | Formula: C26H32O5S
  • H donors: 1 H acceptors: 4 LogP: 4.85 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=CC12CC3C(C2(C(=O)O)C(=C3)C(C)C)(CC2C1CC[C@H]2C)CCOC(=O)c1cccs1
  • InChi: 1S/C26H32O5S/c1-15(2)20-11-17-12-25(14-27)19-7-6-16(3)18(19)13-24(17,26(20,25)23(29)30)8-9-31-22(28)21-5-4-10-32-21/h4-5,10-11,14-19H,6-9,12-13H2,1-3H3,(H,29,30)/t16-,17?,18?,19?,24?,25?,26?/m1/s1
  • InChiKey: MFDSRDLWUSFISB-UNCZFCRKSA-N  


Substructure search Similarity search

Network

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Synonyms

  • AIDS-228143
  • AIDS228143

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0003 0.0013
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0125 0.0569
Echinococcus multilocularis RUN 0.0019 0.0041 0.0175
Onchocerca volvulus Netrin receptor homolog 0.0014 0.0018 0.0073
Brugia malayi Doublecortin family protein 0.0019 0.0041 0.0188
Schistosoma mansoni polycystin 1-related 0.0019 0.0041 0.0098
Trypanosoma cruzi cytochrome P450, putative 0.0036 0.0118 0.9413
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0423 0.1848 0.8544
Schistosoma mansoni rab6-interacting 0.0019 0.0041 0.0098
Onchocerca volvulus 0.0019 0.0041 0.018
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0013
Trichomonas vaginalis esterase, putative 0.0038 0.0125 0.0569
Onchocerca volvulus 0.0095 0.0378 0.178
Loa Loa (eye worm) cytochrome P450 family protein 0.0036 0.0118 0.0544
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0125 1
Loa Loa (eye worm) DOMON domain-containing protein 0.0095 0.0378 0.1747
Brugia malayi Copper type II ascorbate-dependent monooxygenase, N-terminal domain containing protein 0.0251 0.1076 0.4972
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0125 0.0473
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0041 0.0175
Brugia malayi Pre-SET motif family protein 0.0423 0.1848 0.8544
Brugia malayi Bromodomain containing protein 0.0031 0.0093 0.0428
Plasmodium falciparum LCCL domain-containing protein 0.0019 0.0041 0.4386
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0061 0.0227 0.1036
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0049 0.0212
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0003 0.0007
Brugia malayi Cytochrome P450 family protein 0.0036 0.0118 0.0544
Trypanosoma brucei cytochrome P450, putative 0.0036 0.0118 0.9436
Plasmodium vivax SET domain protein, putative 0.0061 0.0227 1
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0093 0.0093
Schistosoma mansoni cytochrome P450 0.0028 0.0079 0.0192
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0073 0.0339
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0041 0.0175
Loa Loa (eye worm) cytochrome P450 family protein 0.0036 0.0118 0.0544
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0073 0.0339
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0003 0.0013
Schistosoma mansoni coup transcription factor 0.0011 0.0003 0.0007
Echinococcus multilocularis PHD finger protein rhinoceros 0.0031 0.0093 0.0416
Trichomonas vaginalis set domain proteins, putative 0.0482 0.211 1
Schistosoma mansoni intermediate filament proteins 0.0026 0.0073 0.0177
Schistosoma mansoni loxhd1 0.0019 0.0041 0.0098
Onchocerca volvulus 0.0038 0.0125 0.0579
Schistosoma mansoni hypothetical protein 0.0028 0.0079 0.0192
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0018 0.0085
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0014 0.0018 0.0084
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0125 0.0473
Echinococcus granulosus intermediate filament protein 0.0026 0.0073 0.0327
Brugia malayi Uncoordinated protein 44 0.0014 0.0018 0.0084
Loa Loa (eye worm) hypothetical protein 0.0017 0.003 0.0137
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0227 0.0548
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0003 0.0013
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0125 0.0473
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0013
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0125 1
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0028 0.0079 0.636
Brugia malayi Cytochrome P450 family protein 0.0036 0.0118 0.0544
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0058 0.0217 0.099
Loa Loa (eye worm) DOMON domain-containing protein 0.0095 0.0378 0.1747
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0014 0.0018 0.0018
Echinococcus granulosus bloom syndrome protein 0.0021 0.0049 0.0212
Loa Loa (eye worm) CYP4Cod1 0.0036 0.0118 0.0544
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0125 0.0569
Loa Loa (eye worm) hypothetical protein 0.0038 0.0125 0.0577
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0003 0.0013
Loa Loa (eye worm) hypothetical protein 0.0019 0.0041 0.0188
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0028 0.0079 0.6207
Echinococcus granulosus lysine specific demethylase 5A 0.0037 0.0121 0.0549
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0125 0.0565
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0003 0.0013
Echinococcus granulosus netrin receptor unc 5 0.0014 0.0018 0.0071
Schistosoma mansoni lamin 0.0026 0.0073 0.0177
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0003 0.0007
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0041 0.0175
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0061 0.0227 0.0548
Brugia malayi hypothetical protein 0.0019 0.0041 0.0188
Loa Loa (eye worm) hypothetical protein 0.0038 0.0125 0.0577
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0046
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0036 0.0118 0.8451
Mycobacterium tuberculosis Conserved protein 0.0038 0.0125 0.0473
Trypanosoma cruzi cytochrome P450, putative 0.0036 0.0118 0.9413
Onchocerca volvulus Alhambra homolog 0.0031 0.0093 0.0426
Echinococcus multilocularis musashi 0.0026 0.0073 0.0327
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0093 0.4082
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0003 0.0013
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0125 0.0302
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0125 0.0577
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0003 0.0013
Giardia lamblia PHD finger protein 15 0.0031 0.0093 0.5
Schistosoma mansoni netrin receptor unc5 0.0014 0.0018 0.0044
Brugia malayi F/Y-rich N-terminus family protein 0.0012 0.001 0.0046
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0125 0.0302
Brugia malayi Immunoglobulin I-set domain containing protein 0.0014 0.0018 0.0084
Brugia malayi PHD-finger family protein 0.0031 0.0093 0.0428
Echinococcus multilocularis 0.0028 0.0079 0.0355
Onchocerca volvulus 0.0019 0.0041 0.018
Echinococcus multilocularis lamin dm0 0.0026 0.0073 0.0327
Schistosoma mansoni dopamine-beta-monooxygenase 0.0935 0.4135 1
Echinococcus multilocularis lamin 0.0026 0.0073 0.0327
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0003 0.0013
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0101 0.0405 0.1863
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0003 0.0013
Loa Loa (eye worm) hypothetical protein 0.0013 0.0012 0.0056
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0013
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0003 0.0013
Onchocerca volvulus 0.0061 0.0227 0.1062
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0125 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0101 0.0405 0.1863
Onchocerca volvulus 0.0482 0.211 1
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0003 0.0013
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0014 0.0019 0.0045
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0028 0.0079 0.6207
Brugia malayi follicle stimulating hormone receptor 0.0227 0.097 0.4485
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0114 0.0466 0.2147
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0003 0.0007
Schistosoma mansoni hypothetical protein 0.0031 0.0093 0.0224
Loa Loa (eye worm) hypothetical protein 0.0061 0.0227 0.1048
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.0029 0.007
Echinococcus multilocularis netrin receptor unc 5 0.0014 0.0018 0.0071
Echinococcus granulosus RUN 0.0019 0.0041 0.0175
Brugia malayi DOMON domain containing protein 0.0095 0.0378 0.1747
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0041 0.0175
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0073 0.0339
Loa Loa (eye worm) hypothetical protein 0.0026 0.0073 0.0339
Loa Loa (eye worm) hypothetical protein 0.0053 0.0191 0.0882
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0014 0.0018 0.0071
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0125 0.0473
Entamoeba histolytica recQ family helicase, putative 0.0011 0.0005 0.5
Echinococcus granulosus peregrin 0.0031 0.0093 0.0416
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0003 0.0007
Loa Loa (eye worm) hypothetical protein 0.0014 0.0019 0.0086
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0003 0.0013
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0018 0.0085
Loa Loa (eye worm) RecQ helicase 0.0021 0.0049 0.0225
Echinococcus granulosus lamin 0.0026 0.0073 0.0327
Leishmania major cytochrome p450-like protein 0.0036 0.0118 0.9413
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0125 0.0565
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0049 0.0207
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0125 0.5507
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0013
Brugia malayi beta-lactamase 0.0038 0.0125 0.0577
Loa Loa (eye worm) hypothetical protein 0.0038 0.0125 0.0577
Brugia malayi beta-lactamase family protein 0.0038 0.0125 0.0577
Plasmodium vivax multidomain scavenger receptor, putative 0.0019 0.0041 0.179
Loa Loa (eye worm) hypothetical protein 0.0038 0.0125 0.0577
Loa Loa (eye worm) cytochrome P450 0.0028 0.0079 0.0367
Brugia malayi Death domain containing protein 0.0014 0.0018 0.0084
Brugia malayi Cytochrome P450 family protein 0.0028 0.0079 0.0367
Loa Loa (eye worm) hypothetical protein 0.0019 0.0041 0.0188
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0003 0.0007
Brugia malayi ecdysteroid receptor 0.0011 0.0003 0.0013
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0125 0.0473
Brugia malayi nuclear receptor NHR-88 0.0011 0.0003 0.0013
Onchocerca volvulus 0.0038 0.0125 0.0579
Leishmania major hypothetical protein, conserved 0.0038 0.0125 1
Echinococcus multilocularis Ankyrin 0.0014 0.0019 0.0074
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0093 0.0093
Brugia malayi steroid hormone receptor 0.0011 0.0003 0.0013
Onchocerca volvulus 0.0038 0.0125 0.0579
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0125 0.0473
Brugia malayi cytochrome P450 0.0028 0.0079 0.0367
Echinococcus granulosus lamin dm0 0.0026 0.0073 0.0327
Onchocerca volvulus 0.0095 0.0378 0.178
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0125 1
Echinococcus granulosus jumonji domain containing protein 0.0043 0.0146 0.0665
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0014 0.0018 0.0808
Mycobacterium tuberculosis Conserved protein 0.0038 0.0125 0.0473
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0018 0.0037 0.4025
Loa Loa (eye worm) PHD-finger family protein 0.0031 0.0093 0.0428
Echinococcus multilocularis lysine specific demethylase 5A 0.0037 0.0121 0.0549
Leishmania major cytochrome p450-like protein 0.0028 0.0079 0.6207
Mycobacterium tuberculosis Conserved protein 0.0038 0.0125 0.0473
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0121 0.0294
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0125 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0227 0.0548
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0003 0.0007
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0121 0.0294
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0003 0.0007
Leishmania major cytochrome p450-like protein 0.0028 0.0079 0.6207
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0003 0.0013
Schistosoma mansoni jumonji domain containing protein 0.008 0.0313 0.0756
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.0005 0.0404
Loa Loa (eye worm) hypothetical protein 0.0038 0.0125 0.0577
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0125 0.0569
Schistosoma mansoni peptidylglycine monooxygenase 0.0494 0.2163 0.523
Brugia malayi Protein kinase domain containing protein 0.0014 0.0018 0.0084
Schistosoma mansoni ankyrin 23/unc44 0.0014 0.0018 0.0044
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0227 0.097 0.4485
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0012 0.0043
Echinococcus multilocularis jumonji domain containing protein 0.0043 0.0146 0.0665
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0041 0.0175
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0046
Echinococcus granulosus cytochrome P450 2K1 0.0028 0.0079 0.0355
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0243 0.1043 0.482
Brugia malayi hypothetical protein 0.0019 0.0041 0.0188
Brugia malayi Cytochrome P450 family protein 0.0028 0.0079 0.0367
Plasmodium falciparum phd finger protein, putative 0.0031 0.0093 1
Mycobacterium ulcerans lipase LipD 0.0038 0.0125 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.0079 0.0367
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0041 0.0175
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0003 0.0007
Brugia malayi beta-lactamase family protein 0.0038 0.0125 0.0577
Loa Loa (eye worm) jmjC domain-containing protein 0.0063 0.0239 0.1104
Schistosoma mansoni rab6-interacting 0.0019 0.0041 0.0098
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0125 0.0577
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0012 0.001 0.0024
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0041 0.0188
Brugia malayi DOMON domain containing protein 0.0095 0.0378 0.1747
Brugia malayi jmjC domain containing protein 0.0037 0.0121 0.0561
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0003 0.0007
Schistosoma mansoni lipoxygenase 0.008 0.0313 0.0756
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0012 0.0043
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0003 0.0013
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0031 0.0093 0.0224
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0125 0.0569
Loa Loa (eye worm) beta-lactamase 0.0038 0.0125 0.0577
Loa Loa (eye worm) hypothetical protein 0.0038 0.0125 0.0577
Echinococcus granulosus peptidyl glycine alpha amidating monooxygenase 0.0494 0.2163 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0003 0.0013
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0028 0.0079 0.6207
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0003 0.0013
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0003 0.0007
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0125 0.0569
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0114 0.0466 0.2147
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0061 0.0227 0.0227
Loa Loa (eye worm) hypothetical protein 0.0014 0.0018 0.0084
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0028 0.0079 0.6207
Mycobacterium ulcerans hypothetical protein 0.0038 0.0125 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0227 0.0548
Mycobacterium leprae Probable lipase LipE 0.0038 0.0125 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0071 0.0329
Schistosoma mansoni lipoxygenase 0.0114 0.0466 0.1128
Echinococcus granulosus death domain containing protein 0.0014 0.0018 0.0071
Echinococcus granulosus histone lysine methyltransferase setb 0.0061 0.0227 0.1036
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0049 0.0225
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0003 0.0013
Brugia malayi DOMON domain containing protein 0.0095 0.0378 0.1747
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0003 0.0013
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0003 0.0013
Onchocerca volvulus 0.0026 0.0073 0.0335
Schistosoma mansoni lamin 0.0026 0.0073 0.0177
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0125 0.0473
Mycobacterium ulcerans beta-lactamase 0.0038 0.0125 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0013
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0003 0.0013
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0003 0.0007
Echinococcus granulosus Ankyrin 0.0014 0.0019 0.0074
Echinococcus multilocularis peregrin 0.0031 0.0093 0.0416
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0049 0.0207
Echinococcus granulosus PHD finger protein rhinoceros 0.0031 0.0093 0.0416
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0013
Schistosoma mansoni hypothetical protein 0.0014 0.0018 0.0044
Schistosoma mansoni hypothetical protein 0.0019 0.0041 0.0098
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0013
Brugia malayi nuclear hormone receptor 0.0011 0.0003 0.0013
Loa Loa (eye worm) jmjC domain-containing protein 0.0037 0.0121 0.0561
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0003 0.0013
Loa Loa (eye worm) hypothetical protein 0.0494 0.2163 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0003 0.0013
Loa Loa (eye worm) hypothetical protein 0.0031 0.0093 0.0428
Onchocerca volvulus 0.0026 0.0073 0.0335
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0243 0.1039 1
Toxoplasma gondii ABC1 family protein 0.0038 0.0125 0.0125
Echinococcus multilocularis peptidyl glycine alpha amidating monooxygenase 0.0494 0.2163 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0013
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0494 0.2163 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0003 0.0013
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0494 0.2163 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0003 0.0007
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0014 0.0018 0.0071
Loa Loa (eye worm) DOMON domain-containing protein 0.0095 0.0378 0.1747
Brugia malayi intermediate filament protein 0.0026 0.0073 0.0339
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0061 0.0227 0.1036
Echinococcus granulosus nuclear factor of activated T cells 5 0.0072 0.0278 0.1273
Brugia malayi jmjC domain containing protein 0.0101 0.0405 0.1873
Loa Loa (eye worm) hypothetical protein 0.0494 0.2163 1
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0125 1
Schistosoma mansoni peptidyl-glycine monooxygenase 0.0494 0.2163 0.523
Brugia malayi Pre-SET motif family protein 0.0061 0.0227 0.1048
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0072 0.0278 0.1273
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0003 0.0013

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) > 128 ug ml-1 Minimum inhibitory concentration to inhibit 90 to 100% visible growth of Candida albicans ChEMBL. 12565963
MIC (functional) > 128 ug ml-1 Minimum inhibitory concentration required to inhibit 90 to 100% visible growth of Candida glabrata ChEMBL. 12565963
MIC (functional) > 128 ug ml-1 Minimum inhibitory concentration to inhibit 90 to 100% visible growth of Candida albicans ChEMBL. 12565963

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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