Detailed information for compound 259683

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 249.375 | Formula: C13H19N3S
  • H donors: 1 H acceptors: 1 LogP: 2.21 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCN1CCC=C2[C@H]1CCc1c2nc(s1)N
  • InChi: 1S/C13H19N3S/c1-2-7-16-8-3-4-9-10(16)5-6-11-12(9)15-13(14)17-11/h4,10H,2-3,5-8H2,1H3,(H2,14,15)/t10-/m1/s1
  • InChiKey: VOPHHPYKMCJUCP-SNVBAGLBSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Dopamine D1 receptor Starlite/ChEMBL No references
Rattus norvegicus Dopamine D2 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum 5-hydroxytryptamine receptor, putative Get druggable targets OG5_132667 All targets in OG5_132667
Schistosoma japonicum 5-hydroxytryptamine receptor 1, putative Get druggable targets OG5_132667 All targets in OG5_132667
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus multilocularis serotonin receptor Dopamine D2 receptor   444 aa 428 aa 31.3 %
Schistosoma japonicum ko:K04145 dopamine receptor D2, putative Dopamine D1 receptor   446 aa 373 aa 25.5 %
Schistosoma japonicum ko:K04136 adrenergic receptor, alpha 1b, putative Dopamine D1 receptor   446 aa 366 aa 35.2 %
Onchocerca volvulus Dopamine D1 receptor   446 aa 357 aa 21.0 %
Onchocerca volvulus Glycoprotein hormone beta 5 homolog Dopamine D2 receptor   444 aa 476 aa 24.2 %
Schistosoma japonicum Octopamine receptor, putative Dopamine D2 receptor   444 aa 456 aa 29.4 %
Echinococcus multilocularis g protein coupled receptor Dopamine D2 receptor   444 aa 465 aa 21.5 %
Schistosoma japonicum ko:K04207 neuropeptide Y receptor Y5, putative Dopamine D2 receptor   444 aa 386 aa 19.7 %
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Dopamine D1 receptor   446 aa 407 aa 33.7 %
Loa Loa (eye worm) hypothetical protein Dopamine D1 receptor   446 aa 370 aa 24.9 %
Schistosoma mansoni biogenic amine (5HT) receptor Dopamine D1 receptor   446 aa 394 aa 29.9 %
Onchocerca volvulus Dopamine D2 receptor   444 aa 418 aa 23.0 %
Schistosoma mansoni biogenic amine receptor Dopamine D2 receptor   444 aa 452 aa 30.1 %
Echinococcus granulosus g protein coupled receptor Dopamine D2 receptor   444 aa 457 aa 21.0 %
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor Dopamine D2 receptor   444 aa 487 aa 23.8 %
Schistosoma mansoni biogenic amine (dopamine) receptor Dopamine D2 receptor   444 aa 494 aa 26.3 %
Schistosoma mansoni amine GPCR Dopamine D2 receptor   444 aa 424 aa 32.1 %
Onchocerca volvulus RB1-inducible coiled-coil protein 1 homolog Dopamine D2 receptor   444 aa 474 aa 23.4 %
Echinococcus granulosus biogenic amine 5HT receptor Dopamine D2 receptor   444 aa 429 aa 31.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.0039 0.0095
Trypanosoma brucei NADH dehydrogenase 0.001 0.0006 0.0034
Echinococcus granulosus hypothetical protein 0.0623 0.1623 0.393
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.001 0.0006 0.0034
Mycobacterium ulcerans hypothetical protein 0.1574 0.4131 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.001 0.0062
Onchocerca volvulus 0.0623 0.1623 0.1623
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.001 0.0006 0.0013
Echinococcus multilocularis smad 0.0018 0.0028 0.0068
Trichomonas vaginalis conserved hypothetical protein 0.0181 0.0456 0.1103
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0623 0.1623 0.393
Brugia malayi nuclear hormone receptor 0.008 0.0191 0.0462
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0025 0.0061
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0623 0.1623 0.393
Trichomonas vaginalis aldo/keto reductase, putative 0.0623 0.1623 0.393
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.0039 0.0095
Brugia malayi MH2 domain containing protein 0.0018 0.0028 0.0068
Trypanosoma cruzi heat shock protein 90, putative 0.0046 0.01 0.0618
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.001 0.0006 0.0034
Trypanosoma cruzi DNA polymerase eta, putative 0.0023 0.0039 0.0241
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0039 0.0241
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.001 0.0006 0.0034
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.032 0.0824 0.5077
Schistosoma mansoni smad1 5 8 and 0.0018 0.0028 0.0068
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0027 0.0051 0.0124
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0025 0.0061
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.008 0.0191 0.0462
Entamoeba histolytica heat shock protein 90, putative 0.0054 0.0121 0.0744
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0037 0.0077 0.0476
Trichomonas vaginalis disulfide oxidoreductase, putative 0.001 0.0006 0.0013
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0046 0.01 0.0243
Echinococcus granulosus FTZ F1 alpha 0.008 0.0191 0.0462
Trypanosoma brucei trypanothione reductase 0.0107 0.0262 0.1611
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0037 0.0077 0.0476
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.001 0.0006 0.0034
Trypanosoma brucei unspecified product 0.0016 0.0021 0.0127
Onchocerca volvulus 0.0623 0.1623 0.1623
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0021 0.0127
Brugia malayi Steroid receptor seven-up type 2 0.008 0.0191 0.0462
Echinococcus granulosus mothers against decapentaplegic 2 0.0008 0.0001 0.0003
Leishmania major heat shock protein 83-1 0.0054 0.0121 0.0744
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0037 0.0077 0.0476
Giardia lamblia DINP protein human, muc B family 0.0023 0.0039 0.0095
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0181 0.0456 0.1103
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0623 0.1623 0.393
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0038 0.0079 0.0079
Echinococcus multilocularis thyroid hormone receptor alpha 0.008 0.0191 0.0462
Leishmania major heat shock protein 83-1 0.0054 0.0121 0.0744
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0037 0.0077 0.1502
Plasmodium falciparum thioredoxin reductase 0.0037 0.0077 0.1502
Schistosoma mansoni glutamate synthase 0.001 0.0006 0.0013
Brugia malayi orphan nuclear receptor NR2E1 0.0038 0.0079 0.0192
Echinococcus granulosus nuclear receptor nhr 48 0.0038 0.0079 0.0192
Echinococcus granulosus thioredoxin glutathione reductase 0.0107 0.0262 0.0633
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0004 0.0025
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0012 0.001 0.0025
Plasmodium falciparum glutathione reductase 0.0107 0.0262 0.5081
Mycobacterium tuberculosis Hypothetical protein 0.1574 0.4131 1
Echinococcus multilocularis glutamate synthase 0.001 0.0006 0.0013
Trichomonas vaginalis aldo-keto reductase, putative 0.0623 0.1623 0.393
Toxoplasma gondii heat shock protein 90, putative 0.0054 0.0121 0.0744
Brugia malayi Nuclear hormone receptor family member nhr-25 0.008 0.0191 0.0462
Mycobacterium ulcerans oxidoreductase 0.0623 0.1623 0.393
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0025 0.0061
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0623 0.1623 0.393
Trichomonas vaginalis apoptosis inducing factor, putative 0.001 0.0006 0.0013
Giardia lamblia Kinase, PLK 0.0214 0.0543 0.1314
Chlamydia trachomatis thioredoxin reductase 0.001 0.0006 0.0716
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.008 0.0191 0.1177
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0017 0.0025 0.0061
Echinococcus granulosus heat shock protein 90 0.0054 0.0121 0.0292
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.008 0.0191 0.0462
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0037 0.0077 0.0476
Loa Loa (eye worm) glutathione reductase 0.0107 0.0262 0.1611
Trypanosoma brucei aldo-keto reductase, putative 0.0623 0.1623 1
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0017 0.0025 0.0488
Onchocerca volvulus 0.0038 0.0079 0.0079
Plasmodium falciparum heat shock protein 90, putative 0.0031 0.0062 0.1198
Mycobacterium leprae Conserved hypothetical protein 0.0443 0.1147 0.2777
Loa Loa (eye worm) endoplasmin 0.0054 0.0121 0.0744
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.001 0.0006 0.0013
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0012 0.001 0.0025
Loa Loa (eye worm) hypothetical protein 0.0038 0.0079 0.0489
Echinococcus granulosus GPCR family 2 0.0053 0.0119 0.0288
Schistosoma mansoni DNA polymerase eta 0.0023 0.0039 0.0095
Leishmania major heat shock protein 83-1 0.0054 0.0121 0.0744
Echinococcus multilocularis aldo keto reductase 0.0623 0.1623 0.393
Plasmodium falciparum glutathione reductase 0.0037 0.0077 0.1502
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0039 0.0241
Schistosoma mansoni importin beta-1 0.003 0.0059 0.0142
Loa Loa (eye worm) thioredoxin reductase 0.0107 0.0262 0.1611
Mycobacterium ulcerans transglutaminase family protein 0.1574 0.4131 1
Echinococcus multilocularis heat shock protein 90 0.0046 0.01 0.0243
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.001 0.0006 0.0013
Trichomonas vaginalis CAMK family protein kinase 0.0106 0.0258 0.0626
Brugia malayi MH2 domain containing protein 0.0018 0.0028 0.0068
Loa Loa (eye worm) latrophilin receptor protein 2 0.0053 0.0119 0.0734
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0038 0.0079 0.0192
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.001 0.0006 0.0013
Plasmodium falciparum ataxin-2 like protein, putative 0.0057 0.013 0.2523
Giardia lamblia Glutamate synthase 0.001 0.0006 0.0013
Schistosoma mansoni aldo-keto reductase 0.0623 0.1623 0.393
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0039 0.0095
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.008 0.0191 0.0462
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.001 0.0006 0.0034
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0029 0.0179
Echinococcus multilocularis bloom syndrome protein 0.0028 0.0054 0.013
Schistosoma mansoni Smad4 0.0008 0.0001 0.0003
Echinococcus granulosus Nuclear hormone receptor HR96 0.0038 0.0079 0.0192
Mycobacterium tuberculosis Conserved protein 0.1574 0.4131 1
Trichomonas vaginalis CAMK family protein kinase 0.0214 0.0543 0.1314
Trypanosoma brucei heat shock protein, putative 0.0054 0.0121 0.0744
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0623 0.1623 0.393
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0008
Toxoplasma gondii aldose reductase, putative 0.0623 0.1623 1
Loa Loa (eye worm) oxidoreductase 0.0623 0.1623 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0044 0.0106
Mycobacterium leprae Conserved hypothetical protein 0.1574 0.4131 1
Schistosoma mansoni nuclear hormone receptor 0.0038 0.0079 0.0192
Trichomonas vaginalis heat shock protein, putative 0.0054 0.0121 0.0292
Schistosoma mansoni DNA helicase recq1 0.0012 0.001 0.0025
Trichomonas vaginalis mercuric reductase, putative 0.0037 0.0077 0.0187
Trypanosoma brucei heat shock protein 90, putative 0.0054 0.0121 0.0744
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0037 0.0077 0.0187
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.001 0.0006 0.0034
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0036 0.0073 0.0178
Toxoplasma gondii heat shock protein HSP90 0.0054 0.0121 0.0744
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.001 0.0006 0.0034
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0038 0.0079 0.0192
Loa Loa (eye worm) oxidoreductase 0.0623 0.1623 1
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0038 0.0079 0.0192
Schistosoma mansoni zinc finger protein 0.0038 0.0079 0.0192
Entamoeba histolytica hypothetical protein 0.0042 0.009 0.0557
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0167 0.042 0.259
Echinococcus granulosus Transglutaminase 0.1574 0.4131 1
Loa Loa (eye worm) pax transcription factor protein 2 0.0263 0.0673 0.4146
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.0039 0.0241
Leishmania major hypothetical protein, conserved 0.001 0.0006 0.0034
Echinococcus granulosus voltage gated potassium channel subunit 0.0181 0.0456 0.1103
Echinococcus multilocularis geminin 0.0565 0.1469 0.3557
Schistosoma mansoni smad1 5 8 and 0.0018 0.0028 0.0068
Brugia malayi tailless protein 0.0038 0.0079 0.0192
Loa Loa (eye worm) hypothetical protein 0.0038 0.0079 0.0489
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.008 0.0191 0.0462
Brugia malayi Thioredoxin family protein 0.1574 0.4131 1
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.001 0.0006 0.0034
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.001 0.0006 0.0034
Echinococcus multilocularis importin subunit beta 1 0.003 0.0059 0.0142
Schistosoma mansoni hypothetical protein 0.0053 0.0119 0.0288
Brugia malayi Hsp90 protein 0.0036 0.0073 0.0178
Trypanosoma brucei Heat shock protein 83, putative 0.0054 0.0121 0.0744
Entamoeba histolytica serine/threonine protein kinase, putative 0.0214 0.0543 0.3344
Loa Loa (eye worm) hypothetical protein 0.0038 0.0079 0.0489
Trypanosoma brucei heat shock protein, putative 0.0054 0.0121 0.0744
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0012 0.001 0.0062
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0042 0.0091 0.0562
Trypanosoma brucei heat shock protein, putative 0.0054 0.0121 0.0744
Onchocerca volvulus 0.0623 0.1623 0.1623
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0039 0.0241
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0039 0.0241
Schistosoma mansoni heat shock protein 0.0036 0.0073 0.0178
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.001 0.0006 0.0108
Brugia malayi hypothetical protein 0.0037 0.0077 0.0185
Schistosoma mansoni endoplasmin 0.0054 0.0121 0.0292
Trypanosoma brucei DNA polymerase eta, putative 0.0023 0.0039 0.0241
Echinococcus granulosus dna polymerase eta 0.0023 0.0039 0.0095
Plasmodium vivax oxidoreductase, aldo/keto reductase domain containing protein 0.0181 0.0456 0.8854
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0059 0.0362
Brugia malayi Nuclear hormone receptor family member nhr-1 0.008 0.0191 0.0462
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0039 0.0095
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0623 0.1623 0.393
Schistosoma mansoni pol-related 0.0623 0.1623 0.393
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0037 0.0077 0.0476
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0623 0.1623 0.393
Echinococcus multilocularis endoplasmin 0.005 0.0112 0.0271
Brugia malayi Cytochrome P450 family protein 0.0046 0.0102 0.0247
Loa Loa (eye worm) hypothetical protein 0.008 0.0191 0.1177
Brugia malayi MH1 domain containing protein 0.0018 0.0028 0.0068
Leishmania major heat shock protein, putative 0.0036 0.0073 0.0452
Trypanosoma brucei hypothetical protein, conserved 0.001 0.0006 0.0034
Brugia malayi nuclear receptor NHR-67 0.0038 0.0079 0.0192
Mycobacterium ulcerans NADH dehydrogenase 0.001 0.0006 0.0013
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.001 0.0006 0.0013
Trypanosoma cruzi heat shock protein 85, putative 0.0054 0.0121 0.0744
Giardia lamblia Thioredoxin reductase 0.001 0.0006 0.0013
Plasmodium falciparum thioredoxin reductase 0.0107 0.0262 0.5081
Plasmodium falciparum importin beta, putative 0.003 0.0059 0.1141
Echinococcus multilocularis snurportin 1 0.032 0.0824 0.1995
Echinococcus multilocularis mothers against decapentaplegic 2 0.0008 0.0001 0.0003
Toxoplasma gondii Hsp90 domain-containing protein 0.0203 0.0515 0.3171
Toxoplasma gondii thioredoxin reductase 0.0107 0.0262 0.1611
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0039 0.0241
Echinococcus granulosus thyroid hormone receptor alpha 0.0038 0.0079 0.0192
Entamoeba histolytica glutamate synthase beta subunit, putative 0.001 0.0006 0.0034
Echinococcus granulosus mothers against decapentaplegic 5 0.0018 0.0028 0.0068
Echinococcus multilocularis dna polymerase kappa 0.0023 0.0039 0.0095
Echinococcus multilocularis Transglutaminase 0.1574 0.4131 1
Leishmania major trypanothione reductase 0.0107 0.0262 0.1611
Loa Loa (eye worm) hypothetical protein 0.008 0.0191 0.1177
Schistosoma mansoni kinase 0.0109 0.0266 0.0644
Echinococcus granulosus Smad4 0.0018 0.0028 0.0068
Treponema pallidum oxidoreductase 0.001 0.0006 0.0494
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0037 0.0077 0.1502
Mycobacterium ulcerans putative transglutaminase-like protein 0.1574 0.4131 1
Entamoeba histolytica thioredoxin reductase, putative 0.001 0.0006 0.0034
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0039 0.0095
Entamoeba histolytica disulphide oxidoreductase, putative 0.001 0.0006 0.0034
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0004 0.001
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0036 0.0073 0.0178
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0039 0.0241
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.001 0.0062
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.0039 0.0095
Echinococcus granulosus heat shock protein 90 0.0046 0.01 0.0243
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0844 0.2204 0.5337
Schistosoma mansoni hypothetical protein 0.0565 0.1469 0.3557
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0037 0.0077 0.0476
Entamoeba histolytica alcohol dehydrogenase, putative 0.0181 0.0456 0.2807
Schistosoma mansoni sulfide quinone reductase 0.001 0.0006 0.0013
Brugia malayi MH1 domain containing protein 0.001 0.0006 0.0016
Trypanosoma cruzi aldo-keto reductase 0.0623 0.1623 1
Leishmania major heat shock protein 83-1 0.0054 0.0121 0.0744
Loa Loa (eye worm) hypothetical protein 0.0623 0.1623 1
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0037 0.0077 0.0187
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0012 0.001 0.0025
Echinococcus granulosus sulfide:quinone oxidoreductase 0.001 0.0006 0.0013
Trypanosoma brucei heat shock protein, putative 0.0054 0.0121 0.0744
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0025 0.0061
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0053 0.0119 0.0288
Plasmodium falciparum heat shock protein 90, putative 0.0203 0.0515 1
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0623 0.1623 0.393
Trypanosoma brucei prostaglandin f synthase 0.0623 0.1623 1
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.001 0.0006 0.0013
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.001 0.0006 0.0108
Brugia malayi Nuclear hormone receptor family member nhr-41 0.008 0.0191 0.0462
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0037 0.0077 0.0476
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.001 0.0006 0.0013
Leishmania major heat shock protein 83-1 0.0054 0.0121 0.0744
Trichomonas vaginalis heat shock protein, putative 0.0046 0.01 0.0243
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0214 0.0543 0.1314
Schistosoma mansoni Smad4 0.0008 0.0001 0.0003
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.001 0.0006 0.0013
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.005 0.0112 0.0271
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0039 0.0241
Schistosoma mansoni retinoid-x-receptor (RXR) 0.008 0.0191 0.0462
Trichomonas vaginalis aldo-keto reductase, putative 0.0181 0.0456 0.1103
Loa Loa (eye worm) heat shock protein 75 0.0036 0.0073 0.0452
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.0039 0.0241
Onchocerca volvulus 0.0181 0.0456 0.0456
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0025 0.0155
Brugia malayi Calcitonin receptor-like protein seb-1 0.0167 0.042 0.1018
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.0039 0.0095
Loa Loa (eye worm) hypothetical protein 0.008 0.0191 0.1177
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.001 0.0006 0.0013
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0623 0.1623 0.393
Loa Loa (eye worm) hypothetical protein 0.0042 0.0091 0.0562
Echinococcus multilocularis voltage gated potassium channel subunit 0.0181 0.0456 0.1103
Brugia malayi glutamate-cysteine ligase modifier subunit 0.0181 0.0456 0.1103
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0039 0.0095
Schistosoma mansoni heat shock protein 0.0054 0.0121 0.0292
Brugia malayi Pax transcription factor protein 2 0.0263 0.0673 0.1629
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.001 0.0006 0.0034
Mycobacterium ulcerans hypothetical protein 0.0181 0.0456 0.1103
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.001 0.0006 0.0013
Brugia malayi hypothetical protein 0.0042 0.0091 0.0221
Trypanosoma brucei heat shock protein, putative 0.0054 0.0121 0.0744
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0037 0.0077 0.0476
Echinococcus multilocularis thioredoxin glutathione reductase 0.0107 0.0262 0.0633
Brugia malayi MH1 domain containing protein 0.001 0.0006 0.0016
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0062
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0027 0.0051 0.0124
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0053 0.0119 0.0288
Echinococcus granulosus aldo keto reductase 0.0623 0.1623 0.393
Trichomonas vaginalis heat shock protein, putative 0.005 0.0112 0.0271
Schistosoma mansoni hypothetical protein 0.0426 0.1102 0.2667
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0042 0.009 0.0219
Trichomonas vaginalis CAMK family protein kinase 0.0214 0.0543 0.1314
Loa Loa (eye worm) hypothetical protein 0.008 0.0191 0.1177
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0025 0.0155
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.005 0.0112 1
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0039 0.0241
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0623 0.1623 0.393
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0147 0.0355
Trypanosoma cruzi NADH dehydrogenase, putative 0.001 0.0006 0.0034
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.001 0.0006 0.0013
Loa Loa (eye worm) hypothetical protein 0.0023 0.0039 0.0241
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0053 0.0119 0.0288
Onchocerca volvulus 0.0263 0.0673 0.0673
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0271 0.0694 0.1681
Schistosoma mansoni hypothetical protein 0.0053 0.0119 0.0288
Loa Loa (eye worm) MH2 domain-containing protein 0.0018 0.0028 0.0173
Trypanosoma cruzi PAB1-binding protein , putative 0.0057 0.013 0.08
Schistosoma mansoni smad 0.0018 0.0028 0.0068
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.001 0.0006 0.0108
Onchocerca volvulus Serine\/threonine kinase homolog 0.0214 0.0543 0.0543
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0025 0.0155
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.001 0.0006 0.0013
Trypanosoma brucei heat shock protein, putative 0.0054 0.0121 0.0744
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0038 0.0079 0.0192
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0037 0.0077 0.6894
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.001 0.0006 0.0494
Mycobacterium tuberculosis Probable reductase 0.0244 0.0623 0.1507
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.001 0.0006 0.0034
Plasmodium vivax heat shock protein 90, putative 0.0036 0.0073 0.1426
Brugia malayi Nuclear hormone receptor family member nhr-40 0.008 0.0191 0.0462
Leishmania major heat shock protein 83-1 0.0054 0.0121 0.0744
Brugia malayi Nuclear hormone receptor-like 1 0.0042 0.0091 0.0221
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0623 0.1623 1
Leishmania major heat shock protein 83-1 0.0054 0.0121 0.0744
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0623 0.1623 0.393
Echinococcus granulosus nuclear receptor 2DBD gamma 0.008 0.0191 0.0462
Entamoeba histolytica aldose reductase, putative 0.0623 0.1623 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0623 0.1623 0.393
Echinococcus multilocularis aldo keto reductase 0.0623 0.1623 0.393
Loa Loa (eye worm) hypothetical protein 0.008 0.0191 0.1177
Mycobacterium ulcerans ferredoxin reductase 0.001 0.0006 0.0013
Leishmania major heat shock protein 83-1 0.0054 0.0121 0.0744
Schistosoma mansoni hypothetical protein 0.1574 0.4131 1
Toxoplasma gondii selenide, water dikinase 0.001 0.0006 0.0034
Loa Loa (eye worm) nuclear factor I 0.001 0.0006 0.004
Plasmodium falciparum heat shock protein 90 0.0054 0.0121 0.2347
Loa Loa (eye worm) hypothetical protein 0.0167 0.042 0.259
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0623 0.1623 0.393
Brugia malayi Thioredoxin reductase 0.0107 0.0262 0.0633
Brugia malayi Nuclear hormone receptor E75 0.0038 0.0079 0.0192
Trichomonas vaginalis glutamate synthase, putative 0.001 0.0006 0.0013
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.001 0.0006 0.0013
Trichomonas vaginalis aldo-keto reductase, putative 0.0623 0.1623 0.393
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.001 0.0006 0.0013
Onchocerca volvulus 0.003 0.0058 0.0058
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0623 0.1623 0.393
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0623 0.1623 0.393
Trypanosoma cruzi polo-like protein kinase, putative 0.0214 0.0543 0.3344
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0037 0.0077 0.0476
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0623 0.1623 0.393
Onchocerca volvulus Bile acid receptor homolog 0.008 0.0191 0.0191
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0019 0.003 0.0575
Trichomonas vaginalis DNA helicase recq1, putative 0.0028 0.0054 0.013
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0038 0.0079 0.0192
Loa Loa (eye worm) hypothetical protein 0.008 0.0191 0.1177
Loa Loa (eye worm) hypothetical protein 0.0038 0.0079 0.0489
Trypanosoma brucei PAB1-binding protein , putative 0.0057 0.013 0.08
Schistosoma mansoni nuclear receptor 0.0038 0.0079 0.0192
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0006 0.0034
Trichomonas vaginalis DNA helicase recq, putative 0.0028 0.0054 0.013
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.001 0.0006 0.0013
Trypanosoma brucei unspecified product 0.0016 0.0021 0.0127
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0008 0.0001 0.0001
Trypanosoma brucei aldo/keto reductase, putative 0.0181 0.0456 0.2807
Brugia malayi RNA, U transporter 1 0.0085 0.0205 0.0495
Brugia malayi nuclear receptor RXR 0.0038 0.0079 0.0192
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0037 0.0077 0.1502
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0053 0.0119 0.0288
Wolbachia endosymbiont of Brugia malayi NADPH-dependent glutamate synthase beta chain 0.001 0.0006 0.0494
Mycobacterium ulcerans monoxygenase 0.001 0.0006 0.0013
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.001 0.0006 0.0013
Entamoeba histolytica recQ family helicase, putative 0.0015 0.0019 0.0118
Leishmania major heat shock protein 83-1 0.0054 0.0121 0.0744
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0037 0.0077 0.0476
Plasmodium vivax ferrodoxin reductase, putative 0.001 0.0006 0.0108
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0037 0.0077 0.1502
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.001 0.0006 0.0013
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0034
Trichomonas vaginalis aldo/keto reductase, putative 0.0623 0.1623 0.393
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0038 0.0079 0.0192
Brugia malayi Nuclear hormone receptor E75 0.0038 0.0079 0.0192
Echinococcus granulosus bloom syndrome protein 0.0028 0.0054 0.013
Entamoeba histolytica aldose reductase, putative 0.0623 0.1623 1
Schistosoma mansoni blooms syndrome DNA helicase 0.0022 0.0038 0.0092
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0039 0.0241
Schistosoma mansoni nuclear receptor nhr-48 0.0038 0.0079 0.0192
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.008 0.0191 0.0462
Plasmodium vivax heat shock protein 86, putative 0.0054 0.0121 0.2347
Brugia malayi Latrophilin receptor protein 2 0.0053 0.0119 0.0288
Trichomonas vaginalis heat shock protein, putative 0.005 0.0112 0.0271
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0018 0.0028 0.0068
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0036 0.0073 0.0073
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.008 0.0191 0.0191
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.001 0.0006 0.0013
Loa Loa (eye worm) programmed cell death 8 0.001 0.0006 0.0034
Onchocerca volvulus 0.0623 0.1623 0.1623
Loa Loa (eye worm) hypothetical protein 0.0038 0.0079 0.0489
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.001 0.0006 0.0013
Mycobacterium tuberculosis Conserved protein 0.0181 0.0456 0.1103
Leishmania major heat shock protein 83-1 0.0054 0.0121 0.0744
Schistosoma mansoni potassium channel beta 0.0181 0.0456 0.1103
Loa Loa (eye worm) hypothetical protein 0.0114 0.0281 0.1731
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0017 0.0025 0.0488
Plasmodium falciparum aldehyde reductase, putative 0.0181 0.0456 0.8854
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0025 0.0061
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0037 0.0077 0.0476
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0623 0.1623 0.393
Echinococcus granulosus glutamate synthase 0.001 0.0006 0.0013
Schistosoma mansoni cpg binding protein 0.0032 0.0063 0.0152
Entamoeba histolytica hypothetical protein 0.0042 0.009 0.0557
Brugia malayi hypothetical protein 0.0038 0.0079 0.0192
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.008 0.0191 0.0462
Schistosoma mansoni smad 0.0008 0.0001 0.0003
Schistosoma mansoni sulfide quinone reductase 0.001 0.0006 0.0013
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0004 0.001
Brugia malayi Bloom's syndrome protein homolog 0.0028 0.0054 0.013
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0038 0.0079 0.0192
Trichomonas vaginalis endoplasmin, putative 0.0039 0.0082 0.0199
Brugia malayi Nuclear hormone receptor family member nhr-49 0.008 0.0191 0.0462
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.001 0.0006 0.0013
Mycobacterium tuberculosis Conserved hypothetical protein 0.1574 0.4131 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0039 0.0241
Loa Loa (eye worm) hypothetical protein 0.0038 0.0079 0.0489
Trichomonas vaginalis aldo-keto reductase, putative 0.0181 0.0456 0.1103
Brugia malayi nuclear hormone receptor family member nhr-6 0.0038 0.0079 0.0192
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0042 0.0091 0.0221
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.008 0.0191 0.0462
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.008 0.0191 0.0462
Loa Loa (eye worm) oxidoreductase 0.0623 0.1623 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0039 0.0241
Loa Loa (eye worm) steroid hormone receptor 0.008 0.0191 0.1177
Loa Loa (eye worm) RecQ helicase 0.0028 0.0054 0.033
Leishmania major heat shock protein 83-1 0.0054 0.0121 0.0744
Trypanosoma cruzi polo-like protein kinase, putative 0.0214 0.0543 0.3344
Treponema pallidum thioredoxin reductase (trxB) 0.001 0.0006 0.0494
Schistosoma mansoni steroid hormone receptor ad4bp 0.008 0.0191 0.0462
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.008 0.0191 0.0462
Leishmania major hypothetical protein, conserved 0.0057 0.013 0.08
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0037 0.0077 1
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0037 0.0077 0.0187
Leishmania major DNA polymerase kappa, putative 0.0023 0.0039 0.0241
Schistosoma mansoni hypothetical protein 0.001 0.0006 0.0013
Schistosoma mansoni Smad4 0.0018 0.0028 0.0068
Echinococcus granulosus dna polymerase kappa 0.0023 0.0039 0.0095
Plasmodium vivax importin-beta 2, putative 0.003 0.0059 0.1141
Brugia malayi Nuclear hormone receptor family member nhr-19 0.008 0.0191 0.0462
Echinococcus multilocularis dnaJ subfamily B 0.0426 0.1102 0.2667
Echinococcus multilocularis dna polymerase eta 0.0023 0.0039 0.0095
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.001 0.0006 0.0013
Echinococcus multilocularis heat shock protein 0.0054 0.0121 0.0292
Trypanosoma brucei heat shock protein, putative 0.0054 0.0121 0.0744
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0025 0.0155
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0037 0.0077 0.0187
Loa Loa (eye worm) Smad1 0.0018 0.0028 0.0173
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0244 0.0623 0.1507
Echinococcus multilocularis ecdysone induced protein 78C 0.008 0.0191 0.0462
Mycobacterium ulcerans hypothetical protein 0.1574 0.4131 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.008 0.0191 0.0462
Mycobacterium ulcerans heat shock protein 90 0.005 0.0112 0.0271
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0037 0.0077 0.0476
Mycobacterium leprae Conserved hypothetical protein 0.1574 0.4131 1
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0077 0.0476
Brugia malayi isocitrate dehydrogenase 0.0017 0.0025 0.0061
Schistosoma mansoni cpg binding protein 0.003 0.0058 0.0141
Brugia malayi Nuclear hormone receptor family member nhr-3 0.008 0.0191 0.0462
Echinococcus multilocularis aldo keto reductase 0.0623 0.1623 0.393
Trichomonas vaginalis CAMK family protein kinase 0.0214 0.0543 0.1314
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.008 0.0191 0.0462
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.0039 0.0095
Loa Loa (eye worm) transcription factor SMAD2 0.027 0.0691 0.4259
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0004 0.0009
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0042 0.0091 0.0221
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0271 0.0694 0.1681
Trichomonas vaginalis glutamate synthase, putative 0.001 0.0006 0.0013
Trypanosoma cruzi Heat shock protein 83, putative 0.0054 0.0121 0.0744
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.008 0.0191 0.0462
Plasmodium vivax endoplasmin, putative 0.0054 0.0121 0.2347
Schistosoma mansoni hypothetical protein 0.0042 0.009 0.0219
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0053 0.0119 0.0288
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0021 0.0127
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.001 0.0006 0.0034
Brugia malayi CXXC zinc finger family protein 0.003 0.0058 0.0141
Trichomonas vaginalis aldo-keto reductase, putative 0.0623 0.1623 0.393
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.001 0.0006 0.0013
Schistosoma mansoni hypothetical protein 0.0053 0.0119 0.0288
Schistosoma mansoni nuclear hormone receptor 0.008 0.0191 0.0462
Trichomonas vaginalis aldo-keto reductase, putative 0.0623 0.1623 0.393
Trypanosoma brucei heat shock protein, putative 0.0054 0.0121 0.0744
Loa Loa (eye worm) glutamate-cysteine ligase modifier subunit 0.0181 0.0456 0.2807
Schistosoma mansoni thyroid hormone receptor 0.008 0.0191 0.0462
Schistosoma mansoni glutamate synthase 0.001 0.0006 0.0013
Toxoplasma gondii oxidoreductase, aldo/keto reductase family protein 0.0181 0.0456 0.2807
Toxoplasma gondii aldo-keto reductase 0.0181 0.0456 0.2807
Loa Loa (eye worm) hypothetical protein 0.0141 0.0352 0.2168
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0039 0.0241
Leishmania major prostaglandin f synthase, putative 0.0623 0.1623 1
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0039 0.0241
Brugia malayi hypothetical protein 0.0518 0.1346 0.3259
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0012 0.001 0.0025
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.001 0.0006 0.0013
Echinococcus multilocularis heat shock protein 90 0.0054 0.0121 0.0292
Leishmania major heat shock protein 83-1 0.0054 0.0121 0.0744
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.001 0.0006 0.0013
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0042 0.0091 0.0221
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0623 0.1623 0.393
Brugia malayi hypothetical protein 0.0042 0.009 0.0219
Schistosoma mansoni cpg binding protein 0.0032 0.0063 0.0152
Trichomonas vaginalis CAMK family protein kinase 0.0106 0.0258 0.0626
Echinococcus multilocularis Smad4 0.0018 0.0028 0.0068
Brugia malayi Endoplasmin precursor 0.0054 0.0121 0.0292
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.1387 0.3636 0.8802
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0044 0.0106
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0244 0.0623 0.1507
Leishmania major NADH dehydrogenase, putative 0.001 0.0006 0.0034
Giardia lamblia Heat shock protein HSP 90-alpha 0.0046 0.01 0.0243
Trypanosoma cruzi heat shock protein 85, putative 0.0054 0.0121 0.0744
Echinococcus multilocularis mothers against decapentaplegic 5 0.0018 0.0028 0.0068
Loa Loa (eye worm) DR-78 0.0038 0.0079 0.0489
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.005 0.0112 0.0691
Echinococcus granulosus Nuclear hormone receptor HR96 0.0038 0.0079 0.0192
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0021 0.0127
Echinococcus granulosus ecdysone induced protein 78C 0.008 0.0191 0.0462
Trichomonas vaginalis disulfide oxidoreductase, putative 0.001 0.0006 0.0013
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0039 0.0241
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.001 0.0006 0.0013
Plasmodium vivax ataxin-2 like protein, putative 0.0057 0.013 0.2523
Trichomonas vaginalis aldo-keto reductase, putative 0.0181 0.0456 0.1103
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0107 0.0262 0.0633
Brugia malayi nuclear receptor RXR 0.0042 0.0091 0.0221
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.001 0.0006 0.0013
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0037 0.0077 0.0187
Brugia malayi hypothetical protein 0.0042 0.0091 0.0221
Trypanosoma cruzi heat shock protein 90, putative 0.0022 0.0039 0.0239
Echinococcus granulosus dnaJ subfamily B 0.0426 0.1102 0.2667
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0167 0.042 0.1018
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0018 0.0028 0.0068
Mycobacterium leprae Possible oxidoreductase 0.0181 0.0456 0.1103
Entamoeba histolytica hypothetical protein 0.0042 0.009 0.0557
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0214 0.0543 0.1314
Echinococcus multilocularis aldehyde reductase 0.0443 0.1147 0.2777
Echinococcus multilocularis nuclear receptor nhr 48 0.0038 0.0079 0.0192
Loa Loa (eye worm) hypothetical protein 0.0518 0.1346 0.8293
Mycobacterium ulcerans hypothetical protein 0.001 0.0006 0.0013
Echinococcus granulosus snurportin 1 0.032 0.0824 0.1995
Giardia lamblia Grp94/Hsp90 0.005 0.0112 0.0271
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.008 0.0191 0.0462
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.008 0.0191 0.0462
Trypanosoma cruzi trypanothione reductase, putative 0.0107 0.0262 0.1611
Brugia malayi Importin beta-1 subunit 0.003 0.0059 0.0142
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0038 0.0079 0.0489
Brugia malayi NADH-dependent xylose reductase 0.0181 0.0456 0.1103
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.008 0.0191 0.0462
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0623 0.1623 0.393
Trypanosoma cruzi aldo/keto reductase, putative 0.0623 0.1623 1
Giardia lamblia Aldose reductase 0.0623 0.1623 0.393
Brugia malayi heat shock protein 90 0.0054 0.0121 0.0292
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0037 0.0077 0.0476
Echinococcus granulosus heat shock protein 0.0054 0.0121 0.0292
Echinococcus granulosus cpg binding protein 0.0032 0.0063 0.0152
Trypanosoma brucei heat shock protein 90, putative 0.0054 0.0121 0.0744
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0042 0.0091 0.0221
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.008 0.0191 0.1177
Giardia lamblia NADH oxidase lateral transfer candidate 0.0037 0.0077 0.0187
Brugia malayi MH1 domain containing protein 0.0018 0.0028 0.0068
Leishmania major heat shock protein 83-1 0.0054 0.0121 0.0744
Leishmania major DNA polymerase eta, putative 0.0023 0.0039 0.0241
Loa Loa (eye worm) hypothetical protein 0.0038 0.0079 0.0489
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0129 0.0794
Trichomonas vaginalis aldo-keto reductase, putative 0.0623 0.1623 0.393
Entamoeba histolytica heat shock protein 90, putative 0.0054 0.0121 0.0744
Echinococcus granulosus aldehyde reductase 0.0443 0.1147 0.2777
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0026 0.0047 0.0114
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.001 0.0006 0.0013
Echinococcus granulosus retinoic acid receptor rxr beta a 0.008 0.0191 0.0462
Leishmania major hypothetical protein, conserved 0.001 0.0006 0.0034
Loa Loa (eye worm) nuclear receptor NHR-67 0.0038 0.0079 0.0489
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0623 0.1623 0.393
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0019 0.0118
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0059 0.0362
Mycobacterium tuberculosis Long conserved protein 0.1574 0.4131 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0079 0.0489
Trichomonas vaginalis aldo-keto reductase, putative 0.0623 0.1623 0.393
Schistosoma mansoni disulfide oxidoreductase 0.001 0.0006 0.0013
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0623 0.1623 0.393
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0039 0.0241
Onchocerca volvulus 0.0623 0.1623 0.1623
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.005 0.0112 0.0271
Schistosoma mansoni glutamate synthase 0.001 0.0006 0.0013
Brugia malayi steroid hormone receptor 0.008 0.0191 0.0462
Onchocerca volvulus 0.0518 0.1346 0.1346
Brugia malayi serine/threonine-protein kinase plk-2 0.0214 0.0543 0.1314
Brugia malayi hypothetical protein 0.0057 0.013 0.0314
Schistosoma mansoni hypothetical protein 0.0114 0.0281 0.068
Trypanosoma brucei heat shock protein 84, putative 0.0036 0.0073 0.0452
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0025 0.0155
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0037 0.0077 0.0476
Schistosoma mansoni retinoic acid receptor RXR 0.008 0.0191 0.0462
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0012 0.001 0.0025
Brugia malayi Nuclear hormone receptor family member nhr-14 0.008 0.0191 0.0462
Trypanosoma cruzi heat shock protein 85, putative 0.0054 0.0121 0.0744
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0012 0.001 0.0197
Loa Loa (eye worm) oxidoreductase 0.0623 0.1623 1
Brugia malayi nuclear receptor NHR-88 0.0038 0.0079 0.0192
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0038 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0038 0.0079 0.0489
Schistosoma mansoni hypothetical protein 0.032 0.0824 0.1995
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.001 0.0006 0.0034
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0623 0.1623 0.393
Mycobacterium tuberculosis Probable oxidoreductase 0.0623 0.1623 0.393
Echinococcus multilocularis GPCR, family 2 0.0053 0.0119 0.0288
Trypanosoma cruzi heat shock protein 90, putative 0.0054 0.0121 0.0744
Trichomonas vaginalis aldo-keto reductase, putative 0.0623 0.1623 0.393
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0001 0.0008
Trichomonas vaginalis aldo-keto reductase, putative 0.0623 0.1623 0.393
Trichomonas vaginalis disulfide oxidoreductase, putative 0.001 0.0006 0.0013
Toxoplasma gondii NADPH-glutathione reductase 0.0037 0.0077 0.0476
Echinococcus granulosus nuclear receptor 2DBD gamma 0.008 0.0191 0.0462
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0244 0.0623 0.1507
Leishmania major heat shock protein 83-1 0.0054 0.0121 0.0744
Schistosoma mansoni RAR-like nuclear receptor 0.008 0.0191 0.0462
Schistosoma mansoni aldo-keto reductase 0.0623 0.1623 0.393
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0038 0.0079 0.0192
Onchocerca volvulus 0.001 0.0006 0.0006
Leishmania major hypothetical protein, conserved 0.001 0.0006 0.0034
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.001 0.0006 0.0013
Trypanosoma cruzi NADH dehydrogenase, putative 0.001 0.0006 0.0034
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0038 0.0079 0.0192
Plasmodium vivax thioredoxin reductase, putative 0.0107 0.0262 0.5081
Leishmania major importin beta-1 subunit, putative 0.0024 0.0044 0.027
Loa Loa (eye worm) hypothetical protein 0.003 0.0059 0.0362
Trypanosoma cruzi heat shock protein, putative 0.0036 0.0073 0.0452
Loa Loa (eye worm) hypothetical protein 0.0042 0.0091 0.0562
Brugia malayi Nuclear hormone receptor-like 1 0.008 0.0191 0.0462
Plasmodium falciparum aldo-keto reductase, putative 0.0181 0.0456 0.8854
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.008 0.0191 0.0462
Trichomonas vaginalis heat shock protein, putative 0.0031 0.0062 0.0149
Trichomonas vaginalis aldo-keto reductase, putative 0.0623 0.1623 0.393
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0025 0.0155
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.001 0.0006 0.0013
Schistosoma mansoni Tr4/Tr2 (homologue) 0.008 0.0191 0.0462
Brugia malayi photoreceptor-specific nuclear receptor 0.008 0.0191 0.0462
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0244 0.0623 0.1507
Brugia malayi Smad1 0.0018 0.0028 0.0068
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0025 0.0155
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.001 0.0006 0.0013
Brugia malayi ecdysone receptor 0.0038 0.0079 0.0192
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0001 0.0008
Schistosoma mansoni hypothetical protein 0.0565 0.1469 0.3557
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.001 0.0006 0.0034
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0019 0.0118
Trichomonas vaginalis DNA helicase recq, putative 0.0015 0.0019 0.0046
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0623 0.1623 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.008 0.0191 0.1177
Brugia malayi nuclear hormone receptor 0.0038 0.0079 0.0192
Schistosoma mansoni serine/threonine protein kinase 0.0214 0.0543 0.1314
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0058 0.036
Brugia malayi Nuclear hormone receptor family member nhr-31 0.008 0.0191 0.0462
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0037 0.0077 0.0476
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0623 0.1623 0.393
Loa Loa (eye worm) hypothetical protein 0.0042 0.0091 0.0562
Loa Loa (eye worm) hypothetical protein 0.0057 0.013 0.08
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0025 0.0045 0.0866
Mycobacterium tuberculosis Probable dehydrogenase 0.0244 0.0623 0.1507
Schistosoma mansoni hypothetical protein 0.0053 0.0119 0.0288
Loa Loa (eye worm) hypothetical protein 0.0038 0.0079 0.0489
Treponema pallidum NADH oxidase 0.0037 0.0077 0.6894
Entamoeba histolytica hypothetical protein 0.0024 0.0044 0.027
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0044 0.027
Echinococcus multilocularis cpg binding protein 0.0032 0.0063 0.0152
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0037 0.0077 0.0187
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0037 0.0077 0.0187
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0025 0.0061
Trichomonas vaginalis heat shock protein, putative 0.0039 0.0082 0.0199
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.008 0.0191 0.0462
Entamoeba histolytica aldose reductase, putative 0.0623 0.1623 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0025 0.0061
Trichomonas vaginalis disulfide oxidoreductase, putative 0.001 0.0006 0.0013
Plasmodium falciparum endoplasmin, putative 0.0039 0.0082 0.1595
Brugia malayi latrophilin 2 splice variant baaae 0.0114 0.0281 0.068
Mycobacterium tuberculosis Conserved hypothetical protein 0.1574 0.4131 1
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.001 0.0006 0.0108
Trichomonas vaginalis aldo-keto reductase, putative 0.0623 0.1623 0.393
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0039 0.0241
Trichomonas vaginalis aldo-keto reductase, putative 0.0623 0.1623 0.393
Trypanosoma cruzi aldo/keto reductase, putative 0.0181 0.0456 0.2807
Plasmodium falciparum ferrodoxin reductase-like protein 0.001 0.0006 0.0108
Plasmodium vivax glutathione reductase, putative 0.0107 0.0262 0.5081
Echinococcus granulosus aldo keto reductase 0.0623 0.1623 0.393
Entamoeba histolytica glutamate synthase beta subunit, putative 0.001 0.0006 0.0034
Loa Loa (eye worm) MH2 domain-containing protein 0.027 0.0691 0.4259
Trichomonas vaginalis aldo/keto reductase, putative 0.0623 0.1623 0.393
Loa Loa (eye worm) hypothetical protein 0.0042 0.0091 0.0562
Echinococcus multilocularis aldo keto reductase 0.0623 0.1623 0.393
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0037 0.0077 0.6894
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0037 0.0077 0.0476
Brugia malayi nuclear receptor NHR-88 0.008 0.0191 0.0462
Echinococcus granulosus mothers against decapentaplegic 6 0.0008 0.0001 0.0003
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0039 0.0241
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.001 0.0006 0.0494
Leishmania major heat shock protein 83-1 0.0054 0.0121 0.0744
Toxoplasma gondii heat shock protein 75, putative 0.0036 0.0073 0.0452
Onchocerca volvulus Protein ultraspiracle homolog 0.008 0.0191 0.0191
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.001 0.0006 0.0013
Loa Loa (eye worm) hypothetical protein 0.0038 0.0079 0.0489
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.008 0.0191 0.1177
Trichomonas vaginalis CAMK family protein kinase 0.0214 0.0543 0.1314
Entamoeba histolytica hypothetical protein 0.0042 0.009 0.0557
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0271 0.0694 0.1681
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0039 0.0095
Leishmania major heat shock protein 83-1 0.0054 0.0121 0.0744
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.001 0.0006 0.0013
Plasmodium falciparum ataxin-2 like protein, putative 0.0057 0.013 0.2523
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.008 0.0191 0.1177
Giardia lamblia Heat shock protein HSP 90-alpha 0.0054 0.0121 0.0292
Loa Loa (eye worm) hypothetical protein 0.008 0.0191 0.1177
Echinococcus granulosus TGF beta signal transducer SmadC 0.0018 0.0028 0.0068
Trichomonas vaginalis aldo-keto reductase, putative 0.0623 0.1623 0.393
Trichomonas vaginalis disulfide oxidoreductase, putative 0.001 0.0006 0.0013
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0214 0.0543 0.3344
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0042 0.009 0.0219
Loa Loa (eye worm) hypothetical protein 0.0038 0.0079 0.0489
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0214 0.0543 0.3344
Brugia malayi conserved hypotetical protein 0.0038 0.0079 0.0192
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0025 0.0061
Brugia malayi glutamate synthase 0.001 0.0006 0.0013
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0037 0.0077 0.0187
Trypanosoma cruzi PAB1-binding protein , putative 0.0057 0.013 0.08
Brugia malayi Nuclear hormone receptor family member nhr-19 0.008 0.0191 0.0462
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0006 0.0034
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0039 0.0241
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0039 0.0095
Schistosoma mansoni heat shock protein 0.0054 0.0121 0.0292
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.001 0.0006 0.0034
Plasmodium vivax aldehyde reductase, putative 0.0181 0.0456 0.8854
Trichomonas vaginalis CAMK family protein kinase 0.0214 0.0543 0.1314
Mycobacterium ulcerans dehydrogenase 0.001 0.0006 0.0013
Mycobacterium ulcerans glutamate synthase subunit beta 0.001 0.0006 0.0013
Trichomonas vaginalis disulfide oxidoreductase, putative 0.001 0.0006 0.0013
Loa Loa (eye worm) MH1 domain-containing protein 0.0018 0.0028 0.0173
Brugia malayi glutathione reductase 0.0107 0.0262 0.0633
Schistosoma mansoni DNA helicase recq5 0.0012 0.001 0.0025
Brugia malayi mothers against decapentaplegic homolog 3 0.0008 0.0001 0.0003
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0037 0.0077 0.0476
Echinococcus granulosus aldo keto reductase family 1, member B4 0.0181 0.0456 0.1103
Brugia malayi nuclear hormone receptor family member odr-7 0.0038 0.0079 0.0192
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0026 0.0047 0.0114
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.004
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.008 0.0191 0.1177
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0623 0.1623 0.393
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.001 0.0006 0.0013
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0623 0.1623 0.393
Schistosoma mansoni coup transcription factor 0.008 0.0191 0.0462
Loa Loa (eye worm) hypothetical protein 0.008 0.0191 0.1177
Schistosoma mansoni nuclear hormone receptor 0.0038 0.0079 0.0192
Trichomonas vaginalis CAMK family protein kinase 0.0214 0.0543 0.1314
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.001 0.0006 0.0034
Onchocerca volvulus 0.008 0.0191 0.0191
Schistosoma mansoni nuclear receptor 0.0038 0.0079 0.0192
Echinococcus granulosus endoplasmin 0.005 0.0112 0.0271
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.001 0.0006 0.0034
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0012 0.001 0.0025
Giardia lamblia Transglutaminase/protease, putative 0.1574 0.4131 1
Entamoeba histolytica alcohol dehydrogenase, putative 0.0181 0.0456 0.2807
Echinococcus multilocularis mothers against decapentaplegic 6 0.0008 0.0001 0.0003
Giardia lamblia Hypothetical protein 0.1574 0.4131 1
Echinococcus granulosus geminin 0.0565 0.1469 0.3557
Echinococcus multilocularis FTZ F1 alpha 0.008 0.0191 0.0462
Leishmania major aldo-keto reductase-like protein 0.0623 0.1623 1
Echinococcus granulosus aldo keto reductase 0.0623 0.1623 0.393
Schistosoma mansoni hypothetical protein 0.0026 0.0047 0.0114
Loa Loa (eye worm) hypothetical protein 0.0042 0.0091 0.0562
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.0039 0.0095
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0025 0.0155
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.001 0.0006 0.0013
Schistosoma mansoni smad1 5 8 and 0.0018 0.0028 0.0068
Trypanosoma brucei unspecified product 0.0023 0.0039 0.0241
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0623 0.1623 0.393
Trichomonas vaginalis glutathione reductase, putative 0.0037 0.0077 0.0187
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0244 0.0623 0.1507
Trichomonas vaginalis CAMK family protein kinase 0.0214 0.0543 0.1314
Schistosoma mansoni transcription factor LCR-F1 0.0042 0.009 0.0219
Treponema pallidum heat shock protein 90 0.005 0.0112 1
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0044 0.0106
Loa Loa (eye worm) hypothetical protein 0.0053 0.0119 0.0734
Loa Loa (eye worm) nuclear hormone receptor 0.0038 0.0079 0.0489
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0059 0.0362
Onchocerca volvulus 0.0623 0.1623 0.1623
Loa Loa (eye worm) cytochrome P450 family protein 0.0046 0.0102 0.063
Onchocerca volvulus 0.0038 0.0079 0.0079
Echinococcus granulosus importin subunit beta 1 0.003 0.0059 0.0142
Leishmania major heat shock protein 83-1 0.0054 0.0121 0.0744
Giardia lamblia Sgs1 DNA helicase, putative 0.0012 0.001 0.0025
Trypanosoma cruzi heat shock protein 85, putative 0.0046 0.01 0.0618
Giardia lamblia Aldose reductase 0.0623 0.1623 0.393
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0623 0.1623 0.393
Loa Loa (eye worm) heat shock protein 90 0.0054 0.0121 0.0744
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.001 0.0006 0.0034
Echinococcus granulosus smad 0.0018 0.0028 0.0068
Loa Loa (eye worm) oxidoreductase 0.0623 0.1623 1
Schistosoma mansoni thyroid hormone receptor 0.008 0.0191 0.0462
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0019 0.0118
Brugia malayi hypothetical protein 0.0038 0.0079 0.0192
Toxoplasma gondii LsmAD domain-containing protein 0.0057 0.013 0.08
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.001 0.0006 0.0034
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0623 0.1623 0.393
Toxoplasma gondii aldo/keto reductase family oxidoreductase 0.0181 0.0456 0.2807
Brugia malayi MH2 domain containing protein 0.0008 0.0001 0.0003
Schistosoma mansoni endoplasmin 0.0054 0.0121 0.0292
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.008 0.0191 0.1177
Brugia malayi Nuclear hormone receptor-like 1 0.0042 0.0091 0.0221
Loa Loa (eye worm) hypothetical protein 0.0038 0.0079 0.0489
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.001 0.0006 0.0034
Leishmania major aldo/keto reductase, putative,aldo/keto reductase family-like protein 0.0181 0.0456 0.2807
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0036 0.0073 0.0452
Brugia malayi ecdysteroid receptor 0.008 0.0191 0.0462
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.001 0.0006 0.0013
Trichomonas vaginalis peptide N-glycanase, putative 0.1574 0.4131 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0271 0.0694 0.1681
Plasmodium vivax heat shock protein, putative 0.0203 0.0515 1
Trypanosoma brucei polo-like protein kinase 0.0214 0.0543 0.3344
Brugia malayi MH2 domain containing protein 0.027 0.0691 0.1674
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.001 0.0006 0.0013

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 4.8 mg kg-1 Compound was evaluated for reversal of the increase in rat striatum DOPA accumulation produced by the pretreatment with GBL (750 mg/Kg, ip) and NSD 1015 (100 mg/Kg, ip) ChEMBL. No reference
IC50 (binding) = 138 nM Compound was evaluated in vitro for binding affinity to Dopamine receptor D1/Dopamine receptor D2 in rat striatal membranes using [3H]-N-propylnorapomorphine ChEMBL. No reference
IC50 (binding) = 860 nM Compound was evaluated in vitro for binding affinity to Dopamine receptor D2 in rat striatal membranes using D2 antagonist [3H]-spiperone ChEMBL. No reference
IC50 (binding) = 860 nM Compound was evaluated in vitro for binding affinity to Dopamine receptor D2 in rat striatal membranes using D2 antagonist [3H]-spiperone ChEMBL. No reference
IC50 (binding) > 15000 nM Compound was evaluated in vitro for binding affinity to Dopamine receptor D1 in rat striatal membranes using D1 antagonist [3H]-SCH-23,390 ChEMBL. No reference
IC50 (binding) > 15000 nM Compound was evaluated in vitro for binding affinity to Dopamine receptor D1 in rat striatal membranes using D1 antagonist [3H]-SCH-23,390 ChEMBL. No reference
Inhibition (functional) = 91 % Compound was evaluated for inhibition of the spontaneous firing of substantia nigra DA neurons in anesthetized rats at 2.5 mg/Kg (ip) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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