Detailed information for compound 281039

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 267.369 | Formula: C17H21N3
  • H donors: 1 H acceptors: 1 LogP: 4.2 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1c2NC=NC(c2cc(c1C)C)C1CCCCC1
  • InChi: 1S/C17H21N3/c1-11-8-14-16(13-6-4-3-5-7-13)19-10-20-17(14)15(9-18)12(11)2/h8,10,13,16H,3-7H2,1-2H3,(H,19,20)
  • InChiKey: JMQNNWUPDOFZTJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) AGC/NDR protein kinase 0.0425 0.2139 0.2139
Schistosoma mansoni atypical protein kinase C 0.0938 0.4991 0.4979
Echinococcus multilocularis synaptotagmin 2 0.0048 0.0047 0.0047
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0722 0.3789 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0047 0.0047
Brugia malayi PXA domain containing protein 0.0125 0.0477 0.0477
Echinococcus granulosus synaptotagmin 0.0048 0.0047 0.0047
Echinococcus multilocularis protein kinase c eta type 0.0326 0.1591 0.1591
Brugia malayi Protein kinase domain containing protein 0.0347 0.171 0.171
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.09 0.4779 0.4779
Echinococcus multilocularis regulator of G protein signaling 0.0125 0.0477 0.0477
Loa Loa (eye worm) hypothetical protein 0.09 0.4778 0.4778
Schistosoma mansoni serine/threonine protein kinase 0.0425 0.2139 0.2121
Schistosoma mansoni fer-1-related 0.0048 0.0047 0.0024
Brugia malayi Protein kinase domain containing protein 0.0425 0.2139 0.2139
Entamoeba histolytica hypothetical protein 0.0125 0.0477 0.0752
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0043 0.0023 0.0023
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0676 0.3537 0.3537
Echinococcus multilocularis synaptotagmin 0.0048 0.0047 0.0047
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0048 0.0047 0.0047
Echinococcus granulosus copine 9 0.0048 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0048 0.0047 0.0047
Schistosoma mansoni regulator of G protein signaling 0.0125 0.0477 0.0455
Brugia malayi C2 domain containing protein 0.0048 0.0047 0.0047
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.033 0.1616 0.1616
Loa Loa (eye worm) Ras association domain family 1 isoform A 0.0326 0.1591 0.1591
Echinococcus multilocularis synaptotagmin 0.0048 0.0047 0.0047
Echinococcus multilocularis synaptotagmin 15 0.0048 0.0047 0.0047
Brugia malayi WW domain containing protein 0.0048 0.0047 0.0047
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0722 0.3789 0.3789
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0043 0.0023 0.0023
Echinococcus multilocularis serine threonine protein kinase 0.1372 0.7401 0.7401
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0374 0.1856 0.1856
Brugia malayi NEDD4.2 0.0048 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0048 0.0047 0.0047
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0043 0.0023 0.0023
Schistosoma mansoni unc-13 (munc13) 0.0374 0.1856 0.1837
Schistosoma mansoni hypothetical protein 0.0048 0.0047 0.0024
Echinococcus granulosus protein kinase c epsilon type 0.1841 1 1
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0125 0.0477 0.0477
Schistosoma mansoni synaptotagmin 0.0048 0.0047 0.0024
Brugia malayi SRC-1 0.0043 0.0023 0.0023
Schistosoma mansoni serine/threonine protein kinase 0.1698 0.9209 0.9207
Echinococcus granulosus otoferlin 0.0048 0.0047 0.0047
Echinococcus multilocularis Regulator of G protein signaling 20 0.0125 0.0477 0.0477
Echinococcus multilocularis synaptotagmin 0.0048 0.0047 0.0047
Echinococcus granulosus synaptotagmin 0.0048 0.0047 0.0047
Loa Loa (eye worm) C2 domain-containing protein 0.0048 0.0047 0.0047
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0722 0.3789 0.3789
Echinococcus granulosus tyrosine protein kinase Fyn 0.0043 0.0023 0.0023
Echinococcus granulosus N chimaerin 0.033 0.1616 0.1616
Leishmania major hypothetical protein, conserved 0.0053 0.0078 0.0083
Schistosoma mansoni synaptotagmin 0.0048 0.0047 0.0024
Brugia malayi C2 domain containing protein 0.0048 0.0047 0.0047
Entamoeba histolytica protein kinase, putative 0.0425 0.2139 0.3658
Loa Loa (eye worm) hypothetical protein 0.0048 0.0047 0.0047
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0722 0.3789 0.3789
Echinococcus granulosus copine 9 0.0048 0.0047 0.0047
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0722 0.3789 1
Schistosoma mansoni serine/threonine protein kinase 0.0337 0.1655 0.1635
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0064 0.0137 0.0137
Leishmania major protein kinase A catalytic subunit isoform 2 0.0722 0.3789 1
Entamoeba histolytica PH domain containing protein kinase, putative 0.0736 0.3867 0.6679
Schistosoma mansoni vav2 0.0344 0.1694 0.1674
Echinococcus multilocularis copine 9 0.0048 0.0047 0.0047
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0722 0.3789 1
Echinococcus granulosus regulator of G protein signaling 7 0.0125 0.0477 0.0477
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0043 0.0023 0.0023
Schistosoma mansoni Mername-AA248 (C02 family) 0.0048 0.0047 0.0024
Loa Loa (eye worm) hypothetical protein 0.034 0.167 0.167
Echinococcus multilocularis axis inhibition protein axin 0.0125 0.0477 0.0477
Entamoeba histolytica protein kinase, putative 0.0069 0.0166 0.0207
Schistosoma mansoni serine/threonine protein kinase 0.0064 0.0137 0.0114
Loa Loa (eye worm) hypothetical protein 0.0278 0.1324 0.1324
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0125 0.0477 0.0477
Schistosoma mansoni synaptotagmin 0.0048 0.0047 0.0024
Brugia malayi Synapse defective protein 1 0.0048 0.0047 0.0047
Brugia malayi C1-like domain containing protein 0.0625 0.3251 0.3251
Echinococcus granulosus tyrosine protein kinase Fyn 0.0043 0.0023 0.0023
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0125 0.0477 0.115
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.033 0.1616 0.1596
Echinococcus granulosus synaptotagmin 0.0048 0.0047 0.0047
Trichomonas vaginalis AGC family protein kinase 0.0439 0.2218 0.58
Echinococcus granulosus myotubularin protein 13 0.034 0.167 0.167
Loa Loa (eye worm) hypothetical protein 0.0048 0.0047 0.0047
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0551 0.2843 0.2843
Entamoeba histolytica PH domain containing protein kinase, putative 0.1078 0.5767 1
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.033 0.1616 0.1616
Schistosoma mansoni regulator of G protein signaling 0.0125 0.0477 0.0455
Echinococcus multilocularis expressed protein 0.0125 0.0477 0.0477
Echinococcus multilocularis intersectin 2 0.0052 0.0071 0.0071
Echinococcus multilocularis RNA directed DNA polymerase 0.09 0.4779 0.4779
Echinococcus multilocularis copine 9 0.0048 0.0047 0.0047
Echinococcus granulosus regulator of G protein signaling 7 0.0125 0.0477 0.0477
Echinococcus granulosus cGMP dependent protein kinase 0.0064 0.0137 0.0137
Loa Loa (eye worm) hypothetical protein 0.09 0.4778 0.4778
Schistosoma mansoni protein kinase C mu 0.0625 0.3251 0.3235
Mycobacterium ulcerans hypothetical protein 0.0043 0.0019 0.5
Loa Loa (eye worm) C2 domain-containing protein 0.0048 0.0047 0.0047
Echinococcus multilocularis beta adrenergic receptor kinase 0.0337 0.1655 0.1655
Schistosoma mansoni serine/threonine protein kinase 0.0347 0.171 0.169
Echinococcus granulosus tyrosine protein kinase Src42A 0.0043 0.0023 0.0023
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0676 0.3537 0.3537
Echinococcus multilocularis extended synaptotagmin 2 0.0048 0.0047 0.0047
Schistosoma mansoni protein kinase C mu 0.0326 0.1591 0.1572
Echinococcus granulosus Diacylglycerol kinase theta 0.0326 0.1591 0.1591
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.033 0.1616 0.1596
Brugia malayi Synaptotagmin I 0.0048 0.0047 0.0047
Schistosoma mansoni phospholipase C-like protein 2 plc-L2 0.0048 0.0047 0.0024
Brugia malayi regulator of G-protein signaling rgs-7 0.0125 0.0477 0.0477
Brugia malayi hypothetical protein 0.0125 0.0477 0.0477
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0403 0.2021 0.5275
Brugia malayi C2 domain containing protein 0.0048 0.0047 0.0047
Schistosoma mansoni synaptotagmin 0.0048 0.0047 0.0024
Brugia malayi C2 domain containing protein 0.0048 0.0047 0.0047
Entamoeba histolytica protein kinase, putative 0.0069 0.0166 0.0207
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0425 0.2139 0.2139
Loa Loa (eye worm) hypothetical protein 0.0048 0.0047 0.0047
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0125 0.0477 0.0477
Echinococcus granulosus tyrosine protein kinase Src64B 0.0043 0.0023 0.0023
Brugia malayi LD23056p 0.0048 0.0047 0.0047
Loa Loa (eye worm) C2 domain-containing protein 0.0048 0.0047 0.0047
Echinococcus granulosus protein kinase c eta type 0.0326 0.1591 0.1591
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0535 0.2753 0.2753
Loa Loa (eye worm) hypothetical protein 0.0326 0.1591 0.1591
Echinococcus granulosus NDR protein kinase 0.0425 0.2139 0.2139
Schistosoma mansoni synaptotagmin 0.0048 0.0047 0.0024
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0066 0.0149 0.0149
Echinococcus granulosus axis inhibition protein axin 0.0125 0.0477 0.0477
Brugia malayi RhoGAP domain containing protein 0.033 0.1616 0.1616
Echinococcus multilocularis multiple C2 and transmembrane domain containing protein 0.0048 0.0047 0.0047
Onchocerca volvulus 0.0278 0.1324 0.2698
Loa Loa (eye worm) hypothetical protein 0.1325 0.7135 0.7135
Loa Loa (eye worm) hypothetical protein 0.0722 0.3789 0.3789
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0722 0.3789 1
Echinococcus multilocularis synaptotagmin 0.0048 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0048 0.0047 0.0047
Loa Loa (eye worm) AGC/PKG protein kinase 0.0064 0.0137 0.0137
Brugia malayi Hr1 repeat family protein 0.0425 0.2139 0.2139
Echinococcus multilocularis expressed conserved protein 0.0064 0.0137 0.0137
Onchocerca volvulus 0.0603 0.3132 0.6522
Echinococcus granulosus myoferlin 0.0048 0.0047 0.0047
Loa Loa (eye worm) G protein-coupled receptor kinase 1 0.0551 0.2843 0.2843
Echinococcus multilocularis calpain 5 0.0048 0.0047 0.0047
Trichomonas vaginalis conserved hypothetical protein 0.0125 0.0477 0.115
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0425 0.2139 0.2139
Schistosoma mansoni serine/threonine protein kinase 0.0722 0.3789 0.3775
Echinococcus granulosus serine:threonine protein kinase N2 0.0425 0.2139 0.2139
Loa Loa (eye worm) hypothetical protein 0.0603 0.3132 0.3132
Brugia malayi protein kinase C3,putative 0.0522 0.2681 0.2681
Loa Loa (eye worm) hypothetical protein 0.09 0.4778 0.4778
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0425 0.2139 0.2139
Schistosoma mansoni axis inhibition protein axin 0.0125 0.0477 0.0455
Schistosoma mansoni copine 0.0048 0.0047 0.0024
Loa Loa (eye worm) hypothetical protein 0.0048 0.0047 0.0047
Loa Loa (eye worm) AGC/AKT protein kinase 0.0439 0.2218 0.2218
Brugia malayi C2 domain containing protein 0.0048 0.0047 0.0047
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0722 0.3789 0.3789
Trichomonas vaginalis AGC family protein kinase 0.0439 0.2218 0.58
Schistosoma mansoni mctp-related 0.0048 0.0047 0.0024
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0299 0.1442 0.1442
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0048 0.0047 0.0047
Echinococcus multilocularis 0.0048 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0048 0.0047 0.0047
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0425 0.2139 0.2139
Echinococcus multilocularis 1 phosphatidylinositol 4,5 bisphosphate 0.0048 0.0047 0.0047
Leishmania major protein kinase A catalytic subunit 0.0722 0.3789 1
Schistosoma mansoni serine/threonine protein kinase 0.0425 0.2139 0.2121
Echinococcus multilocularis C2 calcium lipid binding region, CaLB 0.0048 0.0047 0.0047
Brugia malayi Regulator of G protein signaling domain containing protein 0.0125 0.0477 0.0477
Echinococcus multilocularis Rac GTPase activating protein 1 0.0326 0.1591 0.1591
Echinococcus granulosus tyrosine protein kinase Fyn 0.0043 0.0023 0.0023
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0125 0.0477 0.0455
Schistosoma mansoni serine/threonine protein kinase 0.0337 0.1655 0.1635
Trypanosoma brucei rac serine-threonine kinase, putative 0.0439 0.2218 0.58
Echinococcus granulosus Immunoglobulin E set 0.0048 0.0047 0.0047
Echinococcus granulosus multiple C2 and transmembrane domain containing protein 0.0048 0.0047 0.0047
Echinococcus multilocularis multiple C2 and transmembrane domain containing protein 0.0048 0.0047 0.0047
Echinococcus granulosus synaptotagmin protein 4 0.0048 0.0047 0.0047
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0043 0.0023 0.0023
Echinococcus granulosus protein piccolo 0.0048 0.0047 0.0047
Echinococcus granulosus Rac GTPase activating protein 1 0.0326 0.1591 0.1591
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0722 0.3789 1
Echinococcus multilocularis serine:threonine protein kinase 38 0.0425 0.2139 0.2139
Echinococcus multilocularis myotubularin protein 13 0.034 0.167 0.167
Schistosoma mansoni hypothetical protein 0.0048 0.0047 0.0024
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0722 0.3789 1
Brugia malayi C2 domain containing protein 0.0048 0.0047 0.0047
Schistosoma mansoni hypothetical protein 0.0048 0.0047 0.0024
Loa Loa (eye worm) RhoGAP domain-containing protein 0.033 0.1616 0.1616
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0425 0.2139 0.2139
Schistosoma mansoni rho gtpase activating protein 0.0048 0.0047 0.0024
Echinococcus multilocularis neural cell expressed, developmentally 0.0048 0.0047 0.0047
Trichomonas vaginalis AGC family protein kinase 0.0425 0.2139 0.5591
Loa Loa (eye worm) hypothetical protein 0.0278 0.1324 0.1324
Loa Loa (eye worm) C2 domain-containing protein 0.0048 0.0047 0.0047
Onchocerca volvulus 0.09 0.4778 1
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0048 0.0047 0.0024
Brugia malayi C2 domain containing protein 0.0048 0.0047 0.0047
Brugia malayi Variant SH3 domain containing protein 0.033 0.1616 0.1616
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0043 0.0023 0.0023
Echinococcus granulosus NEDD4 E3 ubiquitin protein ligase WWP1 0.0048 0.0047 0.0047
Entamoeba histolytica diacylglycerol kinase, putative 0.0326 0.1591 0.27
Brugia malayi Ras association domain family 1 isoform A 0.0326 0.1591 0.1591
Echinococcus granulosus raf serine:threonine protein kinase 0.0327 0.1598 0.1598
Schistosoma mansoni serine/threonine protein kinase 0.0327 0.1598 0.1578
Schistosoma mansoni regulator of G protein signaling 0.0125 0.0477 0.0455
Schistosoma mansoni synaptotagmin 0.0048 0.0047 0.0024
Entamoeba histolytica PH domain containing protein kinase, putative 0.0736 0.3867 0.6679
Loa Loa (eye worm) copine family protein 0.0048 0.0047 0.0047
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0043 0.0023 0.0023
Echinococcus granulosus calpain 5 0.0048 0.0047 0.0047
Schistosoma mansoni synaptotagmin 12 0.0048 0.0047 0.0024
Echinococcus granulosus tyrosine protein kinase Lyn 0.0065 0.0142 0.0142
Schistosoma mansoni serine/threonine kinase 0.0425 0.2139 0.2121
Echinococcus multilocularis regulator of G protein signaling 7 0.0125 0.0477 0.0477
Toxoplasma gondii diacylglycerol kinase, putative 0.0326 0.1591 0.4127
Echinococcus multilocularis UNCoordinated family member (unc 13) 0.0048 0.0047 0.0047
Echinococcus multilocularis C2 calcium lipid binding region, CaLB 0.0048 0.0047 0.0047
Echinococcus multilocularis G protein coupled receptor kinase 6 0.0551 0.2843 0.2843
Loa Loa (eye worm) SRC-1 0.0043 0.0023 0.0023
Echinococcus granulosus Protein kinase C brain isozyme 0.1698 0.9209 0.9209
Schistosoma mansoni hypothetical protein 0.0326 0.1591 0.1572
Echinococcus granulosus expressed protein 0.0125 0.0477 0.0477
Echinococcus multilocularis regulator of G protein signaling 7 0.0125 0.0477 0.0477
Schistosoma mansoni rab3 interacting molecule (rim)-related 0.0048 0.0047 0.0024
Brugia malayi Phosphatidylinositol-specific phospholipase C, X domain containing protein 0.0048 0.0047 0.0047
Schistosoma mansoni synaptic ras gtpase activating protein syngap 0.0048 0.0047 0.0024
Brugia malayi Protein kinase c protein 2 0.1295 0.6971 0.6971
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0347 0.171 0.171
Loa Loa (eye worm) hypothetical protein 0.0125 0.0477 0.0477
Brugia malayi C2 domain containing protein 0.0048 0.0047 0.0047
Echinococcus multilocularis unc 13 (munc13) 0.0374 0.1856 0.1856
Loa Loa (eye worm) hypothetical protein 0.0326 0.1591 0.1591
Loa Loa (eye worm) phosphatidylinositol-specific phospholipase C 0.0048 0.0047 0.0047
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0425 0.2139 0.2139
Loa Loa (eye worm) raf kinase 0.0326 0.1591 0.1591
Brugia malayi hypothetical protein 0.0125 0.0477 0.0477
Brugia malayi C2 domain containing protein 0.0048 0.0047 0.0047
Schistosoma mansoni serine/threonine protein kinase 0.0064 0.0137 0.0114
Brugia malayi Egg laying defective protein 4 0.0064 0.0137 0.0137
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0043 0.0023 0.0023
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0064 0.0137 0.0137
Trichomonas vaginalis conserved hypothetical protein 0.0125 0.0477 0.115
Echinococcus multilocularis myoferlin 0.0048 0.0047 0.0047
Entamoeba histolytica protein kinase, putative 0.0439 0.2218 0.3795
Loa Loa (eye worm) AGC/PKA protein kinase 0.0722 0.3789 0.3789
Schistosoma mansoni serine/threonine protein kinase 0.1698 0.9209 0.9207
Brugia malayi C2 domain containing protein 0.0048 0.0047 0.0047
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0048 0.0047 0.0047
Schistosoma mansoni unc-13 (munc13) 0.0374 0.1856 0.1837
Loa Loa (eye worm) hypothetical protein 0.09 0.4779 0.4779
Trichomonas vaginalis AGC family protein kinase 0.0425 0.2139 0.5591
Loa Loa (eye worm) RasGEF domain-containing protein 0.0326 0.1591 0.1591
Loa Loa (eye worm) hypothetical protein 0.0048 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0326 0.1591 0.1591
Loa Loa (eye worm) hypothetical protein 0.0374 0.1856 0.1856
Loa Loa (eye worm) C2 domain-containing protein 0.0048 0.0047 0.0047
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0551 0.2843 0.2843
Trichomonas vaginalis conserved hypothetical protein 0.0125 0.0477 0.115
Echinococcus multilocularis N chimaerin 0.033 0.1616 0.1616
Schistosoma mansoni serine/threonine protein kinase 0.1841 1 1
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0722 0.3789 0.3789
Schistosoma mansoni nedd-4-like E3 ubiquitin-protein ligase 0.0048 0.0047 0.0024
Loa Loa (eye worm) hypothetical protein 0.0125 0.0477 0.0477
Loa Loa (eye worm) Nedd4-PD 0.0048 0.0047 0.0047
Toxoplasma gondii AGC kinase 0.0722 0.3789 1
Loa Loa (eye worm) C2 domain-containing protein 0.0048 0.0047 0.0047
Echinococcus granulosus axis inhibition protein axin 0.0125 0.0477 0.0477
Echinococcus granulosus RNA directed DNA polymerase 0.09 0.4779 0.4779
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0374 0.1856 0.1856
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0425 0.2139 0.2139
Toxoplasma gondii AGC kinase 0.0425 0.2139 0.5591
Trypanosoma cruzi cAMP binding protein, putative 0.0053 0.0078 0.0083
Schistosoma mansoni z-protein (S1r protein) 0.0125 0.0477 0.0455
Echinococcus multilocularis axis inhibition protein axin 0.0125 0.0477 0.0477
Brugia malayi C2 domain containing protein 0.0048 0.0047 0.0047
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0048 0.0047 0.0047
Onchocerca volvulus 0.0374 0.1856 0.3823
Loa Loa (eye worm) RGS-3 protein 0.0125 0.0477 0.0477
Brugia malayi Regulator of G protein signaling domain containing protein 0.0125 0.0477 0.0477
Echinococcus granulosus active breakpoint cluster region 0.0048 0.0047 0.0047
Schistosoma mansoni regulator of G protein signaling 0.0125 0.0477 0.0455
Brugia malayi Pleckstrin Homology Domain 0.034 0.167 0.167
Echinococcus granulosus serine:threonine protein kinase N2 0.1064 0.5688 0.5688
Echinococcus multilocularis serine:threonine protein kinase N2 0.1467 0.7927 0.7927
Trichomonas vaginalis AGC family protein kinase 0.0439 0.2218 0.58
Trichomonas vaginalis AGC family protein kinase 0.0439 0.2218 0.58
Echinococcus multilocularis G protein coupled receptor kinase 1 0.0212 0.096 0.096
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0043 0.0023 0.0023
Echinococcus multilocularis Diacylglycerol kinase theta 0.0326 0.1591 0.1591
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0425 0.2139 0.2139
Brugia malayi RhoGAP domain containing protein 0.0326 0.1591 0.1591
Loa Loa (eye worm) phosphatidylinositol 3-kinase catalytic subunit gamma 0.0048 0.0047 0.0047
Echinococcus granulosus neural cell expressed developmentally 0.0048 0.0047 0.0047
Echinococcus granulosus [G-protein-coupledreceptor] kinase 0.0551 0.2843 0.2843
Schistosoma mansoni hypothetical protein 0.0048 0.0047 0.0024
Schistosoma mansoni diacylglycerol kinase theta 0.0326 0.1591 0.1572
Brugia malayi Copine family protein 0.0048 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0125 0.0477 0.0477
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0722 0.3789 0.3789
Schistosoma mansoni regulator of G protein signaling 0.0125 0.0477 0.0455
Loa Loa (eye worm) hypothetical protein 0.0048 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0326 0.1591 0.1591
Schistosoma mansoni diacylglycerol kinase theta 0.0326 0.1591 0.1572
Schistosoma mansoni serine/threonine protein kinase 0.0425 0.2139 0.2121
Echinococcus multilocularis synaptotagmin 0.0048 0.0047 0.0047
Schistosoma mansoni glut4 vesicle protein-related 0.0048 0.0047 0.0024
Schistosoma mansoni protein kinase C 0.0374 0.1856 0.1837
Echinococcus granulosus synaptotagmin 0.0048 0.0047 0.0047
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0048 0.0047 0.0047
Echinococcus granulosus extended synaptotagmin 2 0.0048 0.0047 0.0047
Echinococcus multilocularis protein kinase c iota type 0.0925 0.492 0.492
Entamoeba histolytica protein kinase, putative 0.0425 0.2139 0.3658
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0722 0.3789 0.3789
Entamoeba histolytica hypothetical protein 0.0326 0.1591 0.27
Echinococcus granulosus multiple C2 and transmembrane domain containing protein 0.0048 0.0047 0.0047
Schistosoma mansoni axis inhibition protein axin 0.0125 0.0477 0.0455
Brugia malayi diacylglycerol kinase 0.0326 0.1591 0.1591
Brugia malayi PXA domain containing protein 0.0125 0.0477 0.0477
Schistosoma mansoni synaptotagmin-like protein 0.0048 0.0047 0.0024
Loa Loa (eye worm) hypothetical protein 0.0326 0.1591 0.1591
Trichomonas vaginalis AGC family protein kinase 0.0425 0.2139 0.5591
Echinococcus granulosus regulator of G protein signaling 3 0.0125 0.0477 0.0477
Loa Loa (eye worm) hypothetical protein 0.0618 0.3211 0.3211
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0625 0.3251 0.3251
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0347 0.171 0.171
Loa Loa (eye worm) AGC/PKA protein kinase 0.0722 0.3789 0.3789
Loa Loa (eye worm) hypothetical protein 0.0125 0.0477 0.0477
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0043 0.0023 0.0023
Brugia malayi RhoGEF domain containing protein 0.0326 0.1591 0.1591
Echinococcus multilocularis regulator of G protein signaling 3 0.0125 0.0477 0.0477
Entamoeba histolytica diacylglycerol kinase, putative 0.0326 0.1591 0.27
Loa Loa (eye worm) hypothetical protein 0.0048 0.0047 0.0047
Echinococcus granulosus protein kinase c iota type 0.0925 0.492 0.492
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0701 0.3671 0.3671
Brugia malayi Synaptotagmin protein 3 0.0048 0.0047 0.0047
Trichomonas vaginalis AGC family protein kinase 0.0439 0.2218 0.58
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0337 0.1655 0.1655
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0125 0.0477 0.0455
Brugia malayi C2 domain containing protein 0.0048 0.0047 0.0047
Echinococcus granulosus Regulator of G protein signaling 20 0.0125 0.0477 0.0477
Loa Loa (eye worm) hypothetical protein 0.0125 0.0477 0.0477
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0425 0.2139 0.2139
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0969 0.5162 0.5162
Brugia malayi Protein kinase domain containing protein 0.0425 0.2139 0.2139
Loa Loa (eye worm) hypothetical protein 0.0326 0.1591 0.1591
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0722 0.3789 0.3789
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0722 0.3789 1
Brugia malayi Variant SH3 domain containing protein 0.0066 0.0149 0.0149
Loa Loa (eye worm) hypothetical protein 0.0048 0.0047 0.0047
Schistosoma mansoni serine/threonine protein kinase 0.0347 0.171 0.169
Loa Loa (eye worm) hypothetical protein 0.1226 0.6587 0.6587
Brugia malayi C2 domain containing protein 0.0048 0.0047 0.0047
Schistosoma mansoni serine/threonine protein kinase 0.0425 0.2139 0.2121
Brugia malayi regulator of G-protein signaling egl-10 0.0125 0.0477 0.0477
Toxoplasma gondii AGC kinase 0.0722 0.3789 1
Echinococcus multilocularis serine:threonine protein kinase N2 0.0425 0.2139 0.2139
Echinococcus granulosus unc 13 munc13 0.0374 0.1856 0.1856
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0425 0.2139 0.2139
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0043 0.0023 0.0023
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0722 0.3789 1
Echinococcus multilocularis raf serine:threonine protein kinase 0.0327 0.1598 0.1598
Brugia malayi Copine VIII 0.0048 0.0047 0.0047
Echinococcus multilocularis protein piccolo 0.0048 0.0047 0.0047
Loa Loa (eye worm) synaptotagmin-1 0.0048 0.0047 0.0047
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0048 0.0047 0.0047
Echinococcus multilocularis NEDD4 E3 ubiquitin protein ligase WWP1 0.0048 0.0047 0.0047
Echinococcus granulosus regulator of G protein signaling 3 0.0125 0.0477 0.0477
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0625 0.3251 0.3251
Echinococcus granulosus cGMP dependent protein kinase 1 0.0064 0.0137 0.0137
Echinococcus granulosus G protein coupled receptor kinase 1 0.0212 0.096 0.096
Schistosoma mansoni unc-13 (munc13) 0.0048 0.0047 0.0024
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0326 0.1591 0.1591
Onchocerca volvulus 0.0618 0.3211 0.6687
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.1841 1 1
Leishmania major protein kinase A catalytic subunit isoform 1 0.0722 0.3789 1
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0048 0.0047 0.0024
Brugia malayi phospholipase C homolog 0.0048 0.0047 0.0047
Schistosoma mansoni E3 ubiquitin-protein ligase nedd-4 0.0048 0.0047 0.0024
Echinococcus multilocularis Protein kinase C, brain isozyme 0.1698 0.9209 0.9209
Schistosoma mansoni synaptotagmin 12 0.0048 0.0047 0.0024
Loa Loa (eye worm) hypothetical protein 0.0048 0.0047 0.0047
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0125 0.0477 0.0455
Trichomonas vaginalis AGC family protein kinase 0.0439 0.2218 0.58
Echinococcus multilocularis synaptotagmin protein 4 0.0048 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0048 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.1226 0.6588 0.6588
Brugia malayi A-kinase anchor protein 10, precursor 0.0125 0.0477 0.0477
Schistosoma mansoni hypothetical protein 0.0048 0.0047 0.0024
Brugia malayi diacylglycerol kinase 0.0326 0.1591 0.1591
Trichomonas vaginalis conserved hypothetical protein 0.0125 0.0477 0.115
Schistosoma mansoni rac gtpase activating protein 0.0326 0.1591 0.1572
Loa Loa (eye worm) hypothetical protein 0.0048 0.0047 0.0047
Brugia malayi p70 ribosomal S6 kinase beta 0.0425 0.2139 0.2139
Brugia malayi Protein kinase domain containing protein 0.0439 0.2218 0.2218
Trichomonas vaginalis AGC family protein kinase 0.0439 0.2218 0.58
Echinococcus granulosus beta-adrenergic receptor kinase 0.0337 0.1655 0.1655
Loa Loa (eye worm) AGC/PKN protein kinase 0.0425 0.2139 0.2139
Loa Loa (eye worm) PXA domain-containing protein 0.0125 0.0477 0.0477
Schistosoma mansoni serine/threonine protein kinase 0.0676 0.3537 0.3522
Echinococcus multilocularis active breakpoint cluster region 0.0048 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0048 0.0047 0.0047
Brugia malayi C2 domain containing protein 0.0048 0.0047 0.0047
Trichomonas vaginalis AGC family protein kinase 0.0722 0.3789 1
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0722 0.3789 1
Echinococcus granulosus protein kinase C gamma type 0.1372 0.7401 0.7401
Loa Loa (eye worm) hypothetical protein 0.0048 0.0047 0.0047
Echinococcus granulosus 1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-4 0.0048 0.0047 0.0047
Echinococcus granulosus C2 calcium lipid binding region CaLB 0.0048 0.0047 0.0047
Entamoeba histolytica hypothetical protein 0.0125 0.0477 0.0752
Echinococcus granulosus synaptotagmin 15 0.0048 0.0047 0.0047
Entamoeba histolytica hypothetical protein 0.0435 0.2199 0.3763
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0048 0.0047 0.0047
Schistosoma mansoni otoferlin 0.0048 0.0047 0.0024
Loa Loa (eye worm) hypothetical protein 0.0048 0.0047 0.0047
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0701 0.3671 0.3671
Entamoeba histolytica protein kinase, putative 0.0439 0.2218 0.3795
Schistosoma mansoni rabphilin-3a 0.0048 0.0047 0.0024
Loa Loa (eye worm) hypothetical protein 0.0125 0.0477 0.0477
Brugia malayi calpain 5 0.0048 0.0047 0.0047
Echinococcus granulosus C2 calcium lipid binding region CaLB 0.0048 0.0047 0.0047
Trichomonas vaginalis conserved hypothetical protein 0.0125 0.0477 0.115
Trichomonas vaginalis AGC family protein kinase 0.0439 0.2218 0.58
Loa Loa (eye worm) hypothetical protein 0.0048 0.0047 0.0047
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0048 0.0047 0.0024
Echinococcus multilocularis regulator of G protein signaling 3 0.0125 0.0477 0.0477
Giardia lamblia Kinase, AGC PKA 0.0722 0.3789 0.5
Schistosoma mansoni serine/threonine protein kinase 0.0722 0.3789 0.3775
Echinococcus granulosus synaptotagmin 0.0048 0.0047 0.0047
Trypanosoma brucei cAMP binding protein, putative 0.0053 0.0078 0.0083
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0064 0.0137 0.0241
Echinococcus granulosus synaptotagmin 2 0.0048 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0048 0.0047 0.0047
Trichomonas vaginalis conserved hypothetical protein 0.0125 0.0477 0.115
Brugia malayi Synapse defective protein 1 0.0048 0.0047 0.0047
Schistosoma mansoni serine/threonine protein kinase 0.0722 0.3789 0.3775
Entamoeba histolytica hypothetical protein 0.0125 0.0477 0.0752
Echinococcus multilocularis protein kinase c epsilon type 0.1841 1 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0047 0.0047
Echinococcus granulosus cGMP dependent protein kinase 1 0.0064 0.0137 0.0137
Echinococcus granulosus UNCoordinated family member unc 13 0.0048 0.0047 0.0047
Plasmodium falciparum cGMP-dependent protein kinase 0.0064 0.0137 0.0241
Echinococcus granulosus intersectin 2 0.0052 0.0071 0.0071
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0722 0.3789 1

Activities

Activity type Activity value Assay description Source Reference
Change (functional) 0 % Evaluated for seizure threshold test at a dose 300 mg/kg & MST is the metrazole seizure threshold to persistent clonus; I = Inactive. ChEMBL. 6330354
Change (functional) 0 % Evaluated for seizure threshold test at a dose 300 mg/kg & MMT is the maximal metrazole threshold to tonic flexion; I = Inactive. ChEMBL. 6330354
ED50 (functional) 0 mg kg-1 Effective dose (ED50) was determined in sc Met (pentylenetetrazol) seizure threshold test; I = Inactive at all doses including 600 mg/kg ChEMBL. 6330354
IC50 (binding) uM Inhibition of binding to GABA-A central benzodiazepine receptor (Inactive at 80 uM) ChEMBL. 6330354
IC50 (binding) 0 uM Inhibition of binding to GABA-A central benzodiazepine receptor (Inactive at 80 uM) ChEMBL. 6330354
TD50 (ADMET) > 600 mg kg-1 Compound was determined in rotorod test and expressed as TD50 ChEMBL. 6330354
TD50 (ADMET) > 600 mg kg-1 Compound was determined in rotorod test and expressed as TD50 ChEMBL. 6330354

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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