Detailed information for compound 28412

Basic information

Technical information
  • TDR Targets ID: 28412
  • Name: [(Z)-4-(6-aminopurin-9-yl)but-2-enoxy]methylp hosphonic acid
  • MW: 299.223 | Formula: C10H14N5O4P
  • H donors: 3 H acceptors: 6 LogP: -1.76 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Nc1ncnc2c1ncn2C/C=C\COCP(=O)(O)O
  • InChi: 1S/C10H14N5O4P/c11-9-8-10(13-5-12-9)15(6-14-8)3-1-2-4-19-7-20(16,17)18/h1-2,5-6H,3-4,7H2,(H2,11,12,13)(H2,16,17,18)/b2-1-
  • InChiKey: CHDFFJQVYZSNQF-UPHRSURJSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • [(Z)-4-adenin-9-ylbut-2-enoxy]methylphosphonic acid
  • AIDS-087777
  • AIDS087777
  • 9-[(Z-4-[Phosphonomethoxy]-but-2-en-1-yl]adenine, ammonium salt

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei cysteine peptidase, Clan CA, family C54, putative 0.005 0.0434 0.2075
Onchocerca volvulus 0.0087 0.0826 0.0616
Echinococcus granulosus geminin 0.0371 0.3818 0.7996
Echinococcus multilocularis heat shock protein 90 0.005 0.0432 0.0877
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0114 0.0442
Leishmania major heat shock protein 83-1 0.005 0.0432 0.2065
Brugia malayi PHD-finger family protein 0.0033 0.0251 0.0495
Entamoeba histolytica peptidase, C54 family 0.005 0.0434 0.1081
Trypanosoma brucei Sterol methyltransferase, putative 0.0198 0.1994 0.9797
Echinococcus multilocularis sodium and chloride dependent glycine 0.003 0.0224 0.0438
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0129 0.1266 0.4912
Echinococcus multilocularis heat shock protein 0.005 0.0432 0.0877
Loa Loa (eye worm) hypothetical protein 0.003 0.0224 0.0209
Echinococcus granulosus PHD finger protein rhinoceros 0.0033 0.0251 0.0495
Echinococcus granulosus survival motor neuron protein 1 0.0244 0.2474 0.517
Leishmania major heat shock protein 83-1 0.005 0.0432 0.2065
Brugia malayi Sodium:neurotransmitter symporter family protein 0.003 0.0224 0.0438
Echinococcus granulosus uncharacterized sodium dependent transporter 0.003 0.0224 0.0438
Brugia malayi vesicular acetylcholine transporter unc-17 0.0461 0.4771 1
Plasmodium falciparum cysteine protease ATG4, putative 0.005 0.0434 0.2227
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0112 0.0435
Brugia malayi Dynamin central region family protein 0.0021 0.0122 0.0225
Brugia malayi Bloom's syndrome protein homolog 0.0026 0.018 0.0347
Plasmodium falciparum transporter, putative 0.003 0.0224 0.1115
Plasmodium falciparum importin beta, putative 0.0028 0.0202 0.1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0139 0.1367 0.1353
Trichomonas vaginalis helicase, putative 0.002 0.0112 0.0435
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0047 0.04 0.5
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0011 0.0015 0.0007
Loa Loa (eye worm) hypothetical protein 0.0213 0.2146 0.2134
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0154 0.1527 0.3178
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0114 0.0247
Plasmodium falciparum phd finger protein, putative 0.0033 0.0251 0.1259
Loa Loa (eye worm) solute carrier family 6 member 4 0.003 0.0224 0.0209
Toxoplasma gondii PHD-finger domain-containing protein 0.0033 0.0251 0.1243
Echinococcus granulosus cysteine protease atg4b 0.0129 0.1266 0.2629
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0185 0.0898
Toxoplasma gondii heat shock protein 75, putative 0.0033 0.0255 0.1264
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0123 0.0108
Leishmania major heat shock protein 83-1 0.005 0.0432 0.2065
Brugia malayi TAR-binding protein 0.0139 0.1367 0.2842
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0018 0.0012
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0034 0.0263 0.1224
Trichomonas vaginalis hypothetical protein 0.0011 0.0015 0.0059
Plasmodium vivax heat shock protein 90, putative 0.0033 0.0255 0.1264
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0114 0.0207
Echinococcus granulosus dynamin 1 protein 0.0021 0.0122 0.0225
Loa Loa (eye worm) hypothetical protein 0.02 0.2019 0.2007
Trypanosoma brucei heat shock protein 90, putative 0.005 0.0432 0.2065
Trypanosoma brucei sterol 24-c-methyltransferase, putative 0.0103 0.0993 0.4843
Schistosoma mansoni DNA helicase recq1 0.0011 0.0018 0.0012
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0145 0.0564
Trichomonas vaginalis heat shock protein, putative 0.005 0.0432 0.1678
Echinococcus granulosus cpg binding protein 0.0092 0.0878 0.1814
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0018 0.0005
Brugia malayi hypothetical protein 0.0027 0.0185 0.0358
Schistosoma mansoni dynamin 0.0021 0.0122 0.0232
Loa Loa (eye worm) CXXC zinc finger family protein 0.0087 0.0826 0.0811
Trypanosoma brucei heat shock protein, putative 0.005 0.0432 0.2065
Plasmodium vivax heat shock protein 86, putative 0.005 0.0432 0.2202
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0225 0.0441
Trichomonas vaginalis heat shock protein, putative 0.0029 0.0211 0.0818
Brugia malayi Latrophilin receptor protein 2 0.0067 0.0613 0.1256
Trypanosoma cruzi lanosterol synthase, putative 0.0202 0.2035 1
Plasmodium falciparum JmjC domain-containing protein, putative 0.0011 0.0015 0.0018
Brugia malayi Dynamin 0.0022 0.0139 0.0261
Trypanosoma cruzi lanosterol synthase, putative 0.0202 0.2035 1
Leishmania major AUT2/APG4/ATG4 cysteine peptidase, putative 0.005 0.0434 0.2075
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0047 0.04 1
Brugia malayi Pre-SET motif family protein 0.0034 0.0258 0.051
Echinococcus granulosus serotonin transporter 0.003 0.0224 0.0438
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0023 0.0145 0.0272
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0202 0.0392
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.02 0.2019 0.4214
Echinococcus multilocularis endoplasmin 0.0047 0.04 0.0809
Echinococcus multilocularis PHD finger protein rhinoceros 0.0033 0.0251 0.0495
Leishmania major heat shock protein 83-1 0.005 0.0432 0.2065
Leishmania major importin beta-1 subunit, putative 0.0023 0.0145 0.0643
Echinococcus granulosus vesicular acetylcholine transporter 0.0461 0.4771 1
Plasmodium falciparum endoplasmin, putative 0.0036 0.0287 0.1451
Plasmodium falciparum histone acetyltransferase GCN5 0.0041 0.0341 0.1733
Toxoplasma gondii histone lysine methyltransferase SET1 0.0171 0.1703 0.891
Loa Loa (eye worm) hypothetical protein 0.0244 0.2474 0.2462
Brugia malayi Dynamin 0.0022 0.0139 0.0261
Echinococcus granulosus heat shock protein 0.005 0.0432 0.0877
Trypanosoma brucei lanosterol synthase 0.0202 0.2035 1
Echinococcus multilocularis survival motor neuron protein 1 0.0244 0.2474 0.517
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.003 0.0224 0.0438
Schistosoma mansoni tar DNA-binding protein 0.0139 0.1367 0.2847
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0114 0.0099
Schistosoma mansoni sodium/chloride dependent transporter 0.003 0.0224 0.0445
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.003 0.0224 0.0445
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0067 0.0613 0.1256
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0034 0.0263 0.1224
Loa Loa (eye worm) isocitrate dehydrogenase 0.0034 0.0263 0.0248
Toxoplasma gondii isocitrate dehydrogenase 0.0034 0.0263 0.1306
Echinococcus granulosus endoplasmin 0.0047 0.04 0.0809
Brugia malayi Isocitrate dehydrogenase 0.0034 0.0263 0.052
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0034 0.0263 0.1306
Echinococcus granulosus lysine specific demethylase 5A 0.0045 0.0376 0.0759
Schistosoma mansoni DNA helicase recq5 0.0011 0.0018 0.0012
Loa Loa (eye worm) RecQ helicase 0.0026 0.018 0.0165
Schistosoma mansoni tar DNA-binding protein 0.0139 0.1367 0.2847
Treponema pallidum sodium- and chloride- dependent transporter 0.003 0.0224 0.3837
Trichomonas vaginalis bromodomain-containing protein, putative 0.0045 0.0381 0.1477
Entamoeba histolytica Ran family GTPase 0.0021 0.0123 0.0284
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0033 0.0255 0.0503
Trypanosoma cruzi heat shock protein 90, putative 0.005 0.0432 0.2065
Plasmodium falciparum amino acid transporter, putative 0.003 0.0224 0.1115
Onchocerca volvulus 0.005 0.0428 0.0209
Echinococcus multilocularis Peptidase C54 0.0129 0.1266 0.2629
Schistosoma mansoni hypothetical protein 0.0067 0.0613 0.1263
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0258 0.0516
Echinococcus granulosus dynamin 0.0021 0.0122 0.0225
Trypanosoma brucei Emopamil binding protein, putative 0.0134 0.1317 0.6446
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0123 0.0533
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0154 0.1527 0.3183
Schistosoma mansoni endoplasmin 0.005 0.0432 0.0884
Schistosoma mansoni hypothetical protein 0.0302 0.3091 0.647
Leishmania major GTP-binding protein, putative 0.0021 0.0123 0.0533
Loa Loa (eye worm) hypothetical protein 0.0033 0.0251 0.0236
Giardia lamblia Grp94/Hsp90 0.0047 0.04 0.098
Plasmodium vivax endoplasmin, putative 0.005 0.0432 0.2202
Brugia malayi latrophilin 2 splice variant baaae 0.0145 0.1436 0.2988
Toxoplasma gondii exonuclease III APE 0.002 0.0114 0.052
Schistosoma mansoni cpg binding protein 0.0092 0.0878 0.182
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0018 0.0091 0.0398
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.02 0.2019 0.4214
Toxoplasma gondii dynamin gtpase 0.0014 0.0048 0.017
Trichomonas vaginalis endoplasmin, putative 0.0036 0.0287 0.1115
Plasmodium falciparum heat shock protein 90 0.005 0.0432 0.2216
Entamoeba histolytica peptidase, C54 family 0.005 0.0434 0.1081
Trichomonas vaginalis dynamin, putative 0.0021 0.0122 0.0475
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0002
Plasmodium vivax hypothetical protein, conserved 0.0033 0.0251 0.1243
Brugia malayi Ceramide glucosyltransferase 0.023 0.2336 0.4879
Treponema pallidum heat shock protein 90 0.0047 0.04 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0112 0.0435
Schistosoma mansoni tar DNA-binding protein 0.0139 0.1367 0.2847
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0033 0.0251 0.0502
Schistosoma mansoni hypothetical protein 0.0371 0.3818 0.7998
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0023 0.0145 0.0272
Trichomonas vaginalis DNA helicase recq, putative 0.0014 0.0051 0.0199
Echinococcus granulosus sodium and chloride dependent glycine 0.003 0.0224 0.0438
Leishmania major AUT2/APG4/ATG4 cysteine peptidase, putative 0.0129 0.1266 0.6191
Toxoplasma gondii PHD-finger domain-containing protein 0.0033 0.0251 0.1243
Schistosoma mansoni hypothetical protein 0.0067 0.0613 0.1263
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0014 0.0048 0.0075
Toxoplasma gondii heat shock protein 90, putative 0.005 0.0432 0.2202
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0108 0.1042 0.2158
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0011 0.0018 0.0005
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0306 0.0611
Entamoeba histolytica hypothetical protein 0.0038 0.0306 0.0753
Loa Loa (eye worm) RNA binding protein 0.0139 0.1367 0.1353
Entamoeba histolytica heat shock protein 90, putative 0.005 0.0432 0.1076
Echinococcus granulosus mixed lineage leukemia protein mll 0.0023 0.0145 0.0272
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.003 0.0224 0.0438
Brugia malayi hypothetical protein 0.0017 0.0085 0.0147
Echinococcus granulosus heat shock protein 90 0.0043 0.0356 0.0716
Loa Loa (eye worm) hypothetical protein 0.003 0.0224 0.0209
Leishmania major heat shock protein 83-1 0.005 0.0432 0.2065
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0185 0.0915
Schistosoma mansoni ran 0.0021 0.0123 0.0233
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0123 0.027
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0114 0.0261
Schistosoma mansoni phd/f-box containing protein 0.0011 0.0015 0.0007
Plasmodium vivax SET domain protein, putative 0.0034 0.0258 0.128
Entamoeba histolytica hypothetical protein 0.0038 0.0306 0.0753
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0011 0.0017 0.0007
Toxoplasma gondii heat shock protein HSP90 0.005 0.0432 0.2202
Schistosoma mansoni jumonji/arid domain-containing protein 0.0045 0.0376 0.0766
Trypanosoma cruzi sterol 24-c-methyltransferase, putative 0.0198 0.1994 0.9797
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0034 0.0263 0.052
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.0258 0.051
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0258 0.0516
Loa Loa (eye worm) hypothetical protein 0.0034 0.0258 0.0243
Trypanosoma brucei sterol 24-c-methyltransferase, putative 0.0198 0.1994 0.9797
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0185 0.0915
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.0258 0.0516
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0011 0.0018 0.0005
Trypanosoma cruzi 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0134 0.1317 0.6446
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.003 0.0224 0.0445
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0123 0.0226
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0306 0.0618
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0213 0.2146 0.4481
Trichomonas vaginalis dynamin, putative 0.0021 0.0122 0.0475
Echinococcus multilocularis cysteine protease atg4b 0.0129 0.1266 0.2629
Schistosoma mansoni vesicular acetylcholine transporter 0.0461 0.4771 1
Trypanosoma brucei heat shock protein 84, putative 0.0033 0.0255 0.1186
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0112 0.0435
Echinococcus multilocularis sodium and chloride dependent glycine 0.003 0.0224 0.0438
Brugia malayi Phospholipase A2 family protein 0.0201 0.2029 0.4234
Toxoplasma gondii isocitrate dehydrogenase 0.0034 0.0263 0.1306
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0034 0.0263 0.0527
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0067 0.0613 0.1256
Toxoplasma gondii Hsp90 domain-containing protein 0.019 0.1909 1
Brugia malayi hypothetical protein 0.0244 0.2474 0.517
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0114 0.0488
Echinococcus multilocularis jumonji domain containing protein 0.0046 0.0387 0.0781
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0011 0.0018 0.0005
Onchocerca volvulus 0.0253 0.2577 0.2407
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0034 0.0258 0.0517
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0112 0.0435
Leishmania major lanosterol synthase, putative 0.0202 0.2035 1
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0123 0.0226
Echinococcus granulosus peregrin 0.0037 0.0291 0.0579
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.0258 0.051
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0015 0.0059
Loa Loa (eye worm) hypothetical protein 0.0016 0.0069 0.0054
Giardia lamblia Ceramide glucosyltransferase 0.0104 0.1006 0.2533
Loa Loa (eye worm) heat shock protein 90 0.005 0.0432 0.0418
Echinococcus multilocularis vesicular acetylcholine transporter 0.0461 0.4771 1
Echinococcus granulosus dynamin 1 0.0022 0.0139 0.0261
Schistosoma mansoni tar DNA-binding protein 0.0139 0.1367 0.2847
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0033 0.0255 0.0503
Echinococcus multilocularis bloom syndrome protein 0.0026 0.018 0.0347
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0123 0.0533
Onchocerca volvulus Phospholipase A2 homolog 0.0201 0.2029 0.1846
Echinococcus granulosus jumonji domain containing protein 0.0046 0.0387 0.0781
Onchocerca volvulus 0.0034 0.0258 0.0035
Trichomonas vaginalis dynamin, putative 0.0021 0.0122 0.0475
Plasmodium vivax dynamin-like protein, putative 0.0021 0.0122 0.0565
Leishmania major heat shock protein 83-1 0.005 0.0432 0.2065
Echinococcus granulosus snurportin 1 0.0302 0.3091 0.6468
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0051 0.0178
Trypanosoma cruzi Emopamil binding protein, putative 0.0134 0.1317 0.6446
Brugia malayi RNA recognition motif domain containing protein 0.0139 0.1367 0.2842
Loa Loa (eye worm) hypothetical protein 0.0129 0.1266 0.1252
Onchocerca volvulus Alhambra homolog 0.0033 0.0251 0.0028
Entamoeba histolytica hypothetical protein 0.0108 0.1046 0.2646
Loa Loa (eye worm) serotonin transporter b 0.003 0.0224 0.0209
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.003 0.0224 0.11
Schistosoma mansoni jumonji domain containing protein 0.0011 0.0015 0.0007
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0114 0.052
Trypanosoma brucei heat shock protein 90, putative 0.005 0.0432 0.2065
Schistosoma mansoni hypothetical protein 0.0371 0.3818 0.7998
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0187 0.1872 0.3909
Giardia lamblia Heat shock protein HSP 90-alpha 0.005 0.0432 0.1063
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0112 0.0435
Schistosoma mansoni family C54 unassigned peptidase (C54 family) 0.0129 0.1266 0.2634
Schistosoma mansoni hypothetical protein 0.0067 0.0613 0.1263
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0011 0.0018 0.0005
Echinococcus granulosus GPCR family 2 0.0067 0.0613 0.1256
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.003 0.0224 0.0445
Echinococcus multilocularis isocitrate dehydrogenase 0.0034 0.0263 0.052
Plasmodium vivax hypothetical protein, conserved 0.003 0.0224 0.11
Entamoeba histolytica acetyltransferase, GNAT family 0.0041 0.0341 0.0842
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.02 0.2019 0.4219
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0067 0.0613 0.1256
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.003 0.0224 0.0445
Toxoplasma gondii hypothetical protein 0.003 0.0224 0.11
Giardia lamblia PHD finger protein 15 0.0033 0.0251 0.0598
Trypanosoma brucei heat shock protein, putative 0.005 0.0432 0.2065
Loa Loa (eye worm) histone methyltransferase 0.0028 0.0201 0.0186
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0428 0.0867
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0045 0.0381 0.1929
Brugia malayi hypothetical protein 0.0153 0.1519 0.3161
Echinococcus multilocularis heat shock protein 90 0.0043 0.0356 0.0716
Trypanosoma cruzi dynamin-1-like protein 0.0021 0.0122 0.053
Loa Loa (eye worm) hypothetical protein 0.0027 0.0185 0.017
Trichomonas vaginalis DNA helicase recq1, putative 0.0026 0.018 0.07
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0123 0.0568
Schistosoma mansoni hypothetical protein 0.0033 0.0251 0.0502
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0016 0.0073 0.0322
Loa Loa (eye worm) hypothetical protein 0.0028 0.0202 0.0187
Schistosoma mansoni hypothetical protein 0.0067 0.0613 0.1263
Trichomonas vaginalis ran, putative 0.0021 0.0123 0.0477
Echinococcus granulosus importin subunit beta 1 0.0028 0.0202 0.0392
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0145 0.0564
Brugia malayi PHD-finger family protein 0.0016 0.0069 0.0114
Loa Loa (eye worm) PHD-finger family protein 0.0033 0.0251 0.0236
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0129 0.1266 0.4912
Schistosoma mansoni importin beta-1 0.0028 0.0202 0.0399
Giardia lamblia Histone acetyltransferase GCN5 0.0041 0.0341 0.0828
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0112 0.0435
Trichomonas vaginalis dynamin, putative 0.0021 0.0122 0.0475
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0045 0.0381 0.1929
Leishmania major heat shock protein 83-1 0.005 0.0432 0.2065
Loa Loa (eye worm) jmjC domain-containing protein 0.0068 0.0621 0.0607
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0018 0.0088 0.0386
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.003 0.0224 0.0209
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0258 0.0516
Schistosoma mansoni family C54 unassigned peptidase (C54 family) 0.0129 0.1266 0.2634
Trichomonas vaginalis heat shock protein, putative 0.0047 0.04 0.1552
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0129 0.1266 0.4912
Brugia malayi Endoplasmin precursor 0.005 0.0432 0.0877
Loa Loa (eye worm) DRP-1 protein 0.0021 0.0122 0.0107
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0051 0.0178
Brugia malayi hypothetical protein 0.003 0.0224 0.0438
Giardia lamblia Dynamin 0.0021 0.0122 0.0268
Loa Loa (eye worm) endoplasmin 0.005 0.0432 0.0418
Leishmania major GTP-binding protein, putative 0.0021 0.0122 0.053
Loa Loa (eye worm) hypothetical protein 0.0145 0.1436 0.1423
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.003 0.003
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0202 0.0984
Leishmania major heat shock protein 83-1 0.005 0.0432 0.2065
Trypanosoma brucei heat shock protein, putative 0.005 0.0432 0.2065
Echinococcus granulosus tar DNA binding protein 0.0139 0.1367 0.2842
Entamoeba histolytica dynamin-1-like protein, putative 0.0021 0.0122 0.0283
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0114 0.0488
Echinococcus multilocularis geminin 0.0371 0.3818 0.7996
Brugia malayi Calcitonin receptor-like protein seb-1 0.0213 0.2146 0.4481
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0202 0.0923
Brugia malayi S-adenosyl-methionine cycloartenol-C24-methyltransferase 0.0097 0.0922 0.1907
Leishmania major heat shock protein 83-1 0.005 0.0432 0.2065
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0112 0.0435
Giardia lamblia Heat shock protein HSP 90-alpha 0.0043 0.0356 0.0867
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0016 0.0068 0.0111
Echinococcus granulosus ceramide glucosyltransferase 0.023 0.2336 0.4879
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0018 0.0012
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0123 0.0226
Loa Loa (eye worm) ceramide glucosyltransferase 0.023 0.2336 0.2324
Schistosoma mansoni cpg binding protein 0.0092 0.0878 0.182
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.02 0.2019 0.4219
Leishmania major heat shock protein 83-1 0.005 0.0432 0.2065
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0034 0.0263 0.1233
Schistosoma mansoni heat shock protein 0.0033 0.0255 0.051
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0112 0.0435
Brugia malayi Importin beta-1 subunit 0.0028 0.0202 0.0392
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0258 0.128
Plasmodium vivax importin-beta 2, putative 0.0028 0.0202 0.0984
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0033 0.0255 0.0621
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0258 0.051
Schistosoma mansoni hypothetical protein 0.0012 0.003 0.0037
Brugia malayi Hsp90 protein 0.0033 0.0255 0.0503
Entamoeba histolytica hypothetical protein 0.0038 0.0306 0.0753
Trypanosoma cruzi Emopamil binding protein, putative 0.0134 0.1317 0.6446
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.02 0.2019 0.4219
Trichomonas vaginalis interferon-induced GTP-binding protein mx, putative 0.0021 0.0122 0.0475
Echinococcus multilocularis tar DNA binding protein 0.0139 0.1367 0.2842
Trypanosoma brucei sterol 24-c-methyltransferase, putative 0.0198 0.1994 0.9797
Schistosoma mansoni hypothetical protein 0.005 0.0428 0.0873
Trypanosoma brucei dynamin-1-like protein 0.0021 0.0122 0.053
Trypanosoma cruzi sterol 24-c-methyltransferase, putative 0.0198 0.1994 0.9797
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0034 0.0263 0.052
Schistosoma mansoni heat shock protein 0.005 0.0432 0.0884
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.003 0.0224 0.0438
Schistosoma mansoni ap endonuclease 0.002 0.0114 0.0214
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0123 0.0568
Loa Loa (eye worm) latrophilin receptor protein 2 0.0067 0.0613 0.0598
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.003 0.0224 0.0209
Schistosoma mansoni endoplasmin 0.005 0.0432 0.0884
Trypanosoma cruzi heat shock protein 90, putative 0.0043 0.0356 0.1687
Mycobacterium tuberculosis Halimadienyl diphosphate synthase 0.0134 0.132 1
Trypanosoma cruzi heat shock protein 85, putative 0.005 0.0432 0.2065
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0302 0.3091 0.308
Echinococcus multilocularis snurportin 1 0.0302 0.3091 0.6468
Brugia malayi RNA, U transporter 1 0.008 0.0752 0.155
Toxoplasma gondii dynamin-related protein DRPB 0.0021 0.0122 0.0565
Loa Loa (eye worm) hypothetical protein 0.003 0.0224 0.0209
Brugia malayi Sodium:neurotransmitter symporter family protein 0.003 0.0224 0.0438
Echinococcus granulosus heat shock protein 90 0.005 0.0432 0.0877
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0034 0.0263 0.1224
Trypanosoma brucei heat shock protein, putative 0.005 0.0432 0.2065
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0047 0.04 0.1904
Leishmania major heat shock protein 83-1 0.005 0.0432 0.2065
Entamoeba histolytica dynamin-like protein 0.0021 0.0122 0.0283
Echinococcus granulosus bloom syndrome protein 0.0026 0.018 0.0347
Brugia malayi Peptidase family C54 containing protein 0.0129 0.1266 0.2629
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0145 0.0564
Entamoeba histolytica hypothetical protein 0.0023 0.0145 0.0341
Schistosoma mansoni hypothetical protein 0.0011 0.0017 0.001
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0028 0.0201 0.039
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0023 0.0147 0.0711
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0112 0.0435
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0114 0.0442
Onchocerca volvulus 0.0153 0.1519 0.1325
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0034 0.0263 0.1224
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0043 0.0356 0.0716
Leishmania major hypothetical protein, conserved 0.0134 0.1317 0.6446
Loa Loa (eye worm) hypothetical protein 0.003 0.0224 0.0209
Schistosoma mansoni cpg binding protein 0.0087 0.0826 0.171
Toxoplasma gondii autophagy-related cysteine peptidase atg4, putative 0.005 0.0434 0.2213
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0108 0.1046 0.2646
Echinococcus multilocularis serotonin transporter 0.003 0.0224 0.0438
Loa Loa (eye worm) hypothetical protein 0.003 0.0224 0.0209
Toxoplasma gondii PHD-finger domain-containing protein 0.0011 0.0017 0.0007
Schistosoma mansoni sodium/chloride dependent transporter 0.003 0.0224 0.0445
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0114 0.0207
Trichomonas vaginalis mgm1, putative 0.0021 0.0122 0.0475
Leishmania major heat shock protein 83-1 0.005 0.0432 0.2065
Plasmodium vivax dynamin protein, putative 0.0021 0.0122 0.0565
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.0461 0.4771 0.4763
Echinococcus multilocularis dynamin 1 protein 0.0021 0.0122 0.0225
Plasmodium falciparum heat shock protein 90, putative 0.0029 0.0211 0.1048
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0045 0.0381 0.1929
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0045 0.0381 0.1477
Plasmodium falciparum dynamin-like protein 0.0021 0.0122 0.0582
Plasmodium falciparum heat shock protein 90, putative 0.019 0.1909 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.0196 0.0181
Loa Loa (eye worm) hypothetical protein 0.0056 0.0499 0.0485
Onchocerca volvulus Ceramide glucosyltransferase homolog 0.023 0.2336 0.216
Onchocerca volvulus 0.0134 0.1317 0.1118
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0034 0.0263 0.1321
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0129 0.1266 0.4912
Brugia malayi RNA binding protein 0.0139 0.1367 0.2842
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.003 0.0224 0.0438
Echinococcus granulosus Peptidase C54 0.0129 0.1266 0.2629
Trypanosoma cruzi heat shock protein 85, putative 0.0043 0.0356 0.1687
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0112 0.0435
Loa Loa (eye worm) hypothetical protein 0.0201 0.2029 0.2017
Leishmania major heat shock protein, putative 0.0033 0.0255 0.1186
Trypanosoma brucei AUT2/APG4/ATG4 cysteine peptidase, putative 0.0129 0.1266 0.6191
Loa Loa (eye worm) acetyltransferase 0.0154 0.1527 0.1514
Schistosoma mansoni autophagin-1 (C54 family) 0.0129 0.1266 0.2634
Leishmania major heat shock protein 83-1 0.005 0.0432 0.2065
Schistosoma mansoni jumonji domain containing protein 0.0086 0.0808 0.1672
Brugia malayi Sodium:neurotransmitter symporter family protein 0.003 0.0224 0.0438
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.003 0.0224 0.11
Leishmania major heat shock protein 83-1 0.005 0.0432 0.2065
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0114 0.0488
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0023 0.0145 0.0272
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0011 0.0017 0.0007
Brugia malayi acetyltransferase, GNAT family protein 0.0154 0.1527 0.3178
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0016 0.0068 0.0111
Schistosoma mansoni protein phosphatase 2C 0.0011 0.0015 0.0007
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0033 0.0255 0.0032
Loa Loa (eye worm) jmjC domain-containing protein 0.0045 0.0376 0.0362
Leishmania major sterol 24-c-methyltransferase, putative 0.0198 0.1994 0.9797
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.003 0.0224 0.5
Trypanosoma cruzi heat shock protein 90, putative 0.0021 0.0125 0.0542
Brugia malayi F/Y-rich N-terminus family protein 0.0039 0.0311 0.0621
Entamoeba histolytica peptidase, C54 family 0.0129 0.1266 0.3209
Loa Loa (eye worm) TAR-binding protein 0.0139 0.1367 0.1353
Brugia malayi jmjC domain containing protein 0.0108 0.1042 0.2158
Brugia malayi heat shock protein 90 0.005 0.0432 0.0877
Trypanosoma brucei heat shock protein, putative 0.005 0.0432 0.2065
Schistosoma mansoni dynamin 0.0022 0.0139 0.0267
Brugia malayi jmjC domain containing protein 0.0045 0.0376 0.0759
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.003 0.0224 0.0445
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.003 0.0224 0.0445
Schistosoma mansoni sodium/chloride dependent transporter 0.003 0.0224 0.0445
Echinococcus granulosus histone acetyltransferase KAT2B 0.0149 0.1481 0.3082
Brugia malayi AF-10 protein 0.0011 0.0017 0.0003
Trypanosoma cruzi AUT2/APG4/ATG4 cysteine peptidase, putative 0.005 0.0434 0.2075
Schistosoma mansoni phosphatidylserine receptor 0.0011 0.0015 0.0007
Schistosoma mansoni heat shock protein 0.005 0.0432 0.0884
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0306 0.0611
Trypanosoma brucei heat shock protein, putative 0.005 0.0432 0.2065
Entamoeba histolytica heat shock protein 90, putative 0.005 0.0432 0.1076
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0067 0.0613 0.1256
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0034 0.0263 0.1224
Onchocerca volvulus Phospholipase A2 homolog 0.0957 1 1
Plasmodium vivax hypothetical protein, conserved 0.0016 0.0073 0.0304
Schistosoma mansoni hypothetical protein 0.0145 0.1436 0.2993
Schistosoma mansoni jumonji/arid domain-containing protein 0.0045 0.0376 0.0766
Brugia malayi hypothetical protein 0.0038 0.0306 0.0611
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0123 0.0585
Schistosoma mansoni ran 0.0021 0.0123 0.0233
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0051 0.0178
Plasmodium vivax amine transporter, putative 0.003 0.0224 0.11
Loa Loa (eye worm) heat shock protein 75 0.0033 0.0255 0.024
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0185 0.0842
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0047 0.04 0.2372
Echinococcus multilocularis cpg binding protein 0.0092 0.0878 0.1814
Entamoeba histolytica peptidase, C54 family 0.005 0.0434 0.1081
Trypanosoma cruzi heat shock protein 85, putative 0.005 0.0432 0.2065
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.003 0.003
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0034 0.0263 0.052
Echinococcus granulosus uncharacterized sodium dependent transporter 0.003 0.0224 0.0438
Schistosoma mansoni hypothetical protein 0.0038 0.0306 0.0618
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0185 0.0842
Echinococcus multilocularis dnaJ subfamily B 0.0434 0.4485 0.9399
Trichomonas vaginalis dynamin, putative 0.0021 0.0122 0.0475
Trypanosoma brucei heat shock protein, putative 0.005 0.0432 0.2065
Entamoeba histolytica hypothetical protein 0.0038 0.0306 0.0753
Echinococcus granulosus sodium and chloride dependent glycine 0.003 0.0224 0.0438
Loa Loa (eye worm) hypothetical protein 0.003 0.0224 0.0209
Schistosoma mansoni ceramide glucosyltransferase 0.023 0.2336 0.4883
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0112 0.0435
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0018 0.0005
Trichomonas vaginalis heat shock protein, putative 0.0036 0.0287 0.1115
Toxoplasma gondii hypothetical protein 0.003 0.0224 0.11
Trypanosoma brucei heat shock protein, putative 0.005 0.0432 0.2065
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0112 0.0435
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.0461 0.4771 0.4651
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0112 0.0435
Loa Loa (eye worm) hypothetical protein 0.003 0.0224 0.0209
Giardia lamblia DNA repair protein RAD52 0.038 0.3919 1
Loa Loa (eye worm) hypothetical protein 0.02 0.2019 0.2007
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0015 0.0059
Brugia malayi Sodium:neurotransmitter symporter family protein 0.003 0.0224 0.0438
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0213 0.2146 0.2134
Brugia malayi Cytochrome P450 family protein 0.0028 0.0196 0.038
Leishmania major hypothetical protein, conserved 0.0027 0.0185 0.0842
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0034 0.0263 0.052
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0112 0.0435
Trypanosoma cruzi heat shock protein 85, putative 0.005 0.0432 0.2065
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0123 0.0533
Trichomonas vaginalis set domain proteins, putative 0.0253 0.2577 1
Loa Loa (eye worm) norepinephrine transporter 0.003 0.0224 0.0209
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0112 0.0435
Echinococcus granulosus histone acetyltransferase KAT2B 0.0045 0.0381 0.0768
Loa Loa (eye worm) hypothetical protein 0.0132 0.1299 0.1286
Echinococcus multilocularis dynamin 0.0021 0.0122 0.0225
Trypanosoma cruzi AUT2/APG4/ATG4 cysteine peptidase, putative 0.0129 0.1266 0.6191
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0112 0.0435
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.038 0.3919 1
Trypanosoma brucei Heat shock protein 83, putative 0.005 0.0432 0.2065
Trichomonas vaginalis dynamin, putative 0.0021 0.0122 0.0475
Entamoeba histolytica recQ family helicase, putative 0.0014 0.0051 0.0101
Schistosoma mansoni dynamin 0.0022 0.0139 0.0267
Plasmodium vivax heat shock protein, putative 0.019 0.1909 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0185 0.0842
Leishmania major heat shock protein 83-1 0.005 0.0432 0.2065
Leishmania major heat shock protein 83-1 0.005 0.0432 0.2065
Trypanosoma cruzi sterol 24-c-methyltransferase, putative 0.0198 0.1994 0.9797
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0223 0.2255 0.2243
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0028 0.0201 0.039
Brugia malayi CXXC zinc finger family protein 0.0087 0.0826 0.1704
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0114 0.0207
Schistosoma mansoni ceramide glucosyltransferase 0.023 0.2336 0.4883
Mycobacterium ulcerans heat shock protein 90 0.0047 0.04 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.0613 0.0598
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0145 0.0643
Echinococcus multilocularis lysine specific demethylase 5A 0.004 0.0324 0.0649
Trichomonas vaginalis heat shock protein, putative 0.0043 0.0356 0.1382
Echinococcus multilocularis GPCR, family 2 0.0067 0.0613 0.1256
Echinococcus granulosus dnaJ subfamily B 0.0434 0.4485 0.9399
Trypanosoma cruzi cysteine peptidase, Clan CA, family C54, putative 0.005 0.0434 0.2075
Trichomonas vaginalis heat shock protein, putative 0.0047 0.04 0.1552
Loa Loa (eye worm) hypothetical protein 0.0153 0.1519 0.1505
Brugia malayi Bromodomain containing protein 0.0037 0.0291 0.0579
Trypanosoma cruzi Heat shock protein 83, putative 0.005 0.0432 0.2065
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0114 0.0537
Leishmania major heat shock protein 83-1 0.005 0.0432 0.2065
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0108 0.1042 0.2158
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0114 0.0488
Schistosoma mansoni hypothetical protein 0.0434 0.4485 0.9399
Schistosoma mansoni sodium-dependent amino acid transporter 0.003 0.0224 0.0445
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0011 0.0017 0.0007
Schistosoma mansoni survival motor neuron protein 0.005 0.0428 0.0873
Echinococcus multilocularis dynamin 1 0.0022 0.0139 0.0261
Leishmania major sterol 24-c-methyltransferase, putative 0.0198 0.1994 0.9797
Schistosoma mansoni blooms syndrome DNA helicase 0.0021 0.0122 0.0231
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0112 0.0435
Echinococcus multilocularis ceramide glucosyltransferase 0.023 0.2336 0.4879
Schistosoma mansoni tar DNA-binding protein 0.0139 0.1367 0.2847
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0011 0.0018 0.003
Trichomonas vaginalis DNA helicase recq, putative 0.0026 0.018 0.07
Brugia malayi Pre-SET motif family protein 0.0223 0.2255 0.4709
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.003 0.0224 0.11
Trypanosoma brucei dynamin-1-like protein 0.0021 0.0122 0.053
Schistosoma mansoni ap endonuclease 0.002 0.0114 0.0214
Leishmania major 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0134 0.1317 0.6446
Toxoplasma gondii dynamin-related protein DRPA 0.0021 0.0122 0.0565
Brugia malayi isocitrate dehydrogenase 0.0034 0.0263 0.052
Loa Loa (eye worm) hypothetical protein 0.0022 0.0139 0.0124
Loa Loa (eye worm) hypothetical protein 0.0097 0.0922 0.0908
Echinococcus multilocularis peregrin 0.0037 0.0291 0.0579
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0202 0.0923
Trypanosoma cruzi heat shock protein, putative 0.0033 0.0255 0.1186
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0011 0.0018 0.0002
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0129 0.1266 0.4912
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0034 0.0263 0.052
Plasmodium falciparum dynamin-like protein 0.0021 0.0122 0.0582
Trypanosoma cruzi 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0134 0.1317 0.6446
Loa Loa (eye worm) hypothetical protein 0.003 0.0224 0.0209
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0185 0.0898
Entamoeba histolytica peptidase, C54 family 0.005 0.0434 0.1081
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0067 0.0613 0.1256

Activities

Activity type Activity value Assay description Source Reference
CC50 (functional) >= 250 uM The lowest concentration of compound producing overt cytotoxicity in virus-free vero cell cultures ChEMBL. No reference
CC50 (functional) > 250 uM The lowest concentration of compound producing overt cytotoxicity in virus-free MRC-5 cell cultures ChEMBL. No reference
CC50 (functional) > 250 uM The lowest concentration of compound producing overt cytotoxicity in virus-free MRC-5 cell cultures ChEMBL. No reference
CC50 (functional) > 1000 uM Cytotoxic concentration required to reduce the viability of MT-4 cells ChEMBL. No reference
CC50 (functional) > 1000 uM Cytotoxic concentration required to reduce the viability of MT-4 cells ChEMBL. No reference
EC50 (functional) = 38 uM Concentration required to inhibit p24 viral antigen production by 50% in C-8166 cells ChEMBL. No reference
EC50 (functional) = 38 uM Concentration required to inhibit p24 viral antigen production by 50% in C-8166 cells ChEMBL. No reference
EC50 (functional) = 170 uM Concentration required to inhibit HIV-1-induced cytopathic effect by 50% in MT-4 cells ChEMBL. No reference
EC50 (functional) = 170 uM Concentration required to inhibit HIV-1-induced cytopathic effect by 50% in MT-4 cells ChEMBL. No reference
EC50 (functional) > 250 uM Anti-herpes virus activity of the compound was evaluated against Herpes simplex virus type 1 (HSV-1,strain HF) grown in Vero cells ChEMBL. No reference
EC50 (functional) > 250 uM Anti-herpes virus activity of the compound was evaluated against Herpes simplex virus type 2 (HSV-2,strain G) grown in Vero cells ChEMBL. No reference
EC50 (functional) > 250 uM Anti-herpes virus activity of the compound was evaluated against human cytomegalovirus (HCMV,strain AD-169) grown in MRC-5 cells ChEMBL. No reference
EC50 (functional) > 250 uM Anti-herpes virus activity of the compound was evaluated against human cytomegalovirus (HCMV,strain AD-169) grown in MRC-5 cells ChEMBL. No reference
ED50 (functional) = 9 uM Anti HIV-l activity in infected MT-4 cells cultures ChEMBL. 7525958
ED50 (functional) = 9 uM Anti HIV-l activity in infected MT-4 cells cultures ChEMBL. 7525958

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.