Detailed information for compound 291216

Basic information

Technical information
  • TDR Targets ID: 291216
  • Name: 5-[(2,5-dimethylthiophen-3-yl)methyl]-1H-imid azole
  • MW: 192.281 | Formula: C10H12N2S
  • H donors: 1 H acceptors: 1 LogP: 2.5 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1sc(c(c1)Cc1c[nH]cn1)C
  • InChi: 1S/C10H12N2S/c1-7-3-9(8(2)13-7)4-10-5-11-6-12-10/h3,5-6H,4H2,1-2H3,(H,11,12)
  • InChiKey: GDSOYSZXNMRHKH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-[(2,5-dimethyl-3-thienyl)methyl]-1H-imidazole
  • 4-[(2,5-dimethylthiophen-3-yl)methyl]-3H-imidazole
  • 4-[(2,5-dimethyl-3-thienyl)methyl]-3H-imidazole

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni kinase 0.0115 0.0086 0.0649
Plasmodium falciparum casein kinase 2, alpha subunit 0.0159 0.0125 0.4924
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0071 0.0048 0.048
Trichomonas vaginalis PIKK family atypical protein kinase 0.0918 0.0785 0.881
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.0013 0.0107
Brugia malayi Cytochrome P450 family protein 0.0023 0.0005 0.0058
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0953 0.0816 0.2234
Giardia lamblia Kinase, CMGC GSK 0.0059 0.0037 0.0268
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0199 0.0159 0.0158
Schistosoma mansoni protein kinase 0.0159 0.0125 0.0942
Echinococcus multilocularis regulator of G protein signaling 3 0.0022 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0548 0.0463 0.393
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0043 0.0023 0.02
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0037 0.0018 0.0018
Brugia malayi PAS domain containing protein 0.0057 0.0035 0.0391
Brugia malayi Immunoglobulin I-set domain containing protein 0.0017 0 0.0001
Trypanosoma brucei protein kinase, putative 0.0059 0.0037 0.0386
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0071 0.0048 0.048
Loa Loa (eye worm) phosphatidylinositol 3-kinase catalytic subunit gamma 0.0056 0.0034 0.0288
Echinococcus granulosus tumor protein p63 0.0393 0.0328 0.0328
Brugia malayi Regulator of G protein signaling domain containing protein 0.0022 0.0005 0.0055
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0059 0.0037 0.0316
Loa Loa (eye worm) hypothetical protein 0.0021 0.0004 0.0034
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.0003 0.0018
Onchocerca volvulus Serine\/threonine kinase homolog 0.0223 0.018 0.5778
Trichomonas vaginalis conserved hypothetical protein 0.0325 0.0269 0.2979
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.1532 0.132 0.132
Trichomonas vaginalis PIKK family atypical protein kinase 0.0927 0.0793 0.8898
Loa Loa (eye worm) hypothetical protein 0.0381 0.0318 0.2697
Loa Loa (eye worm) hypothetical protein 0.0058 0.0036 0.0302
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0031 0.0013 0.0013
Echinococcus granulosus Regulator of G protein signaling 20 0.0022 0.0005 0.0005
Trichomonas vaginalis casein kinase II beta chain, putative 0.0043 0.0023 0.02
Schistosoma mansoni axis inhibition protein axin 0.0022 0.0005 0.0037
Echinococcus granulosus protein kinase shaggy 0.0059 0.0037 0.0037
Schistosoma mansoni 6-phosphofructokinase 0.0127 0.0096 0.0725
Echinococcus granulosus nuclear factor of activated T cells 5 0.0086 0.006 0.006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0572 0.0484 0.5408
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0017 0 0.0000000037793
Echinococcus multilocularis lamin 0.0031 0.0013 0.0013
Echinococcus multilocularis high voltage activated calcium channel beta 0.0101 0.0074 0.0073
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0464 0.039 0.4376
Entamoeba histolytica hypothetical protein 0.0541 0.0457 0.5101
Giardia lamblia Casein kinase II beta chain 0.0043 0.0023 0.009
Schistosoma mansoni hypothetical protein 0.0196 0.0156 0.118
Loa Loa (eye worm) phosphatidylinositol 3 0.0199 0.0159 0.1345
Entamoeba histolytica serine/threonine protein kinase, putative 0.0223 0.018 0.1977
Loa Loa (eye worm) hypothetical protein 0.0037 0.0018 0.0153
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0975 0.0835 0.9372
Trichomonas vaginalis PIKK family atypical protein kinase 0.0953 0.0816 0.9161
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0953 0.0816 0.9776
Loa Loa (eye worm) voltage-dependent calcium channel beta 2a subunit 0.0208 0.0167 0.1415
Trichomonas vaginalis PIKK family atypical protein kinase 0.0541 0.0457 0.5101
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.0016 0.0015
Echinococcus multilocularis cyclin dependent kinase 19 0.0156 0.0121 0.0121
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0536 0.0453 0.5057
Trichomonas vaginalis PIKK family atypical protein kinase 0.0566 0.0479 0.5354
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0302 0.0248 0.0248
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0071 0.0048 0.048
Echinococcus multilocularis axis inhibition protein axin 0.0022 0.0005 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0048 0.048
Brugia malayi hypothetical protein 0.019 0.0151 0.1697
Mycobacterium ulcerans putative regulatory protein 0.0023 0.0005 0.0007
Loa Loa (eye worm) phosphatidylinositol 3 0.0199 0.0159 0.1345
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0768 0.0655 0.7355
Trichomonas vaginalis PIKK family atypical protein kinase 0.0948 0.0811 0.9108
Echinococcus granulosus bloom syndrome protein 0.0025 0.0007 0.0007
Loa Loa (eye worm) cytochrome P450 family protein 0.0035 0.0016 0.0132
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.024 0.0195 0.1652
Onchocerca volvulus 0.0117 0.0087 0.2803
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0005 0.001
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0042 0.0022 0.0022
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0199 0.0159 0.178
Echinococcus multilocularis regulator of G protein signaling 0.0022 0.0005 0.0005
Echinococcus multilocularis survival motor neuron protein 1 0.0548 0.0463 0.0463
Toxoplasma gondii hypothetical protein 0.0062 0.004 0.0492
Echinococcus multilocularis regulator of G protein signaling 3 0.0022 0.0005 0.0005
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0031 0.0013 0.0144
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0037 0.0018 0.0202
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0302 0.0248 0.071
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0071 0.0048 0.048
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0015 0.0117
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.1039 0.089 0.2559
Schistosoma mansoni hypothetical protein 0.0381 0.0318 0.2407
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0302 0.0248 1
Mycobacterium ulcerans 6-phosphofructokinase 0.0127 0.0096 1
Trichomonas vaginalis conserved hypothetical protein 0.058 0.0491 0.5488
Brugia malayi Bloom's syndrome protein homolog 0.0025 0.0007 0.0078
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0127 0.0096 0.5907
Trichomonas vaginalis casein kinase II beta chain, putative 0.0043 0.0023 0.02
Echinococcus multilocularis transfer RNA-Lys 0.0042 0.0022 0.0022
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0302 0.0248 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0071 0.0048 0.048
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0975 0.0835 0.2285
Schistosoma mansoni serine/threonine protein kinase 0.0026 0.0009 0.0063
Echinococcus granulosus regulator of G protein signaling 3 0.0022 0.0005 0.0005
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0199 0.0159 0.0158
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0034 0.0015 0.0449
Brugia malayi A-kinase anchor protein 10, precursor 0.0022 0.0005 0.0055
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1039 0.089 1
Loa Loa (eye worm) RecQ helicase 0.0025 0.0007 0.0059
Entamoeba histolytica phosphofructokinase, putative 0.0127 0.0096 0.1026
Leishmania major casein kinase II, putative 0.0159 0.0125 0.0336
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0302 0.0248 0.2748
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0464 0.039 0.4634
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0302 0.0248 0.188
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0519 0.0438 0.3318
Echinococcus granulosus expressed conserved protein 0.0095 0.0068 0.0068
Schistosoma mansoni serine/threonine protein kinase 0.0223 0.018 0.1363
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0071 0.0048 0.048
Entamoeba histolytica protein kinase, putative 0.0059 0.0037 0.0364
Schistosoma mansoni single-minded 0.0057 0.0035 0.0263
Brugia malayi PXA domain containing protein 0.0024 0.0007 0.0071
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0104 0.0076 0.0574
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0043 0.0023 0.0725
Trichomonas vaginalis PIKK family atypical protein kinase 0.0593 0.0503 0.5618
Leishmania major phosphatidylinositol kinase, putative 0.0199 0.0159 0.043
Giardia lamblia GTOR 0.0975 0.0835 1
Brugia malayi Protein kinase domain containing protein 0.0021 0.0004 0.0039
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0048 0.0028 0.0257
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0199 0.0159 0.1955
Toxoplasma gondii ck2 beta subunit 0.0043 0.0023 0.0281
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0541 0.0457 0.3459
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.004 0.0394
Loa Loa (eye worm) hypothetical protein 0.0117 0.0087 0.0741
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0005 0.0037
Schistosoma mansoni lamin 0.0031 0.0013 0.0095
Entamoeba histolytica protein kinase domain containing protein 0.0159 0.0125 0.135
Loa Loa (eye worm) hypothetical protein 0.0017 0 0.0002
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0361 0.03 0.3473
Plasmodium vivax casein kinase II beta chain, putative 0.0043 0.0023 0.0913
Trichomonas vaginalis CAMK family protein kinase 0.0223 0.018 0.1977
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0766 0.0653 0.0652
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0223 0.018 0.018
Mycobacterium ulcerans putative regulatory protein 0.0023 0.0005 0.0007
Brugia malayi Pre-SET motif family protein 0.024 0.0195 0.2187
Loa Loa (eye worm) phosphatidylinositol 3 0.0918 0.0785 0.666
Trichomonas vaginalis casein kinase II beta chain, putative 0.0043 0.0023 0.02
Echinococcus granulosus serine protein kinase ATM 0.0541 0.0457 0.0457
Trichomonas vaginalis CMGC family protein kinase 0.0159 0.0125 0.135
Loa Loa (eye worm) PXA domain-containing protein 0.0024 0.0007 0.0054
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0034 0.0015 0.0449
Trichomonas vaginalis PIKK family atypical protein kinase 0.0927 0.0793 0.8898
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0374 0.0312 1
Echinococcus multilocularis regulator of G protein signaling 7 0.0022 0.0005 0.0005
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0302 0.0248 0.2748
Leishmania major hypothetical protein, conserved 0.4203 0.3647 1
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0159 0.0125 0.5013
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0342 0.0284 0.0812
Trichomonas vaginalis CMGC family protein kinase 0.0159 0.0125 0.135
Loa Loa (eye worm) hypothetical protein 0.0022 0.0005 0.0042
Schistosoma mansoni hypothetical protein 0.006 0.0038 0.0283
Brugia malayi PXA domain containing protein 0.0024 0.0007 0.0071
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0199 0.0159 0.6387
Loa Loa (eye worm) CMGC/CDK/CDK8 protein kinase 0.0156 0.0121 0.1028
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0037 0.0364
Schistosoma mansoni hypothetical protein 0.0112 0.0083 0.0628
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0199 0.0159 0.1735
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0302 0.0248 0.2106
Loa Loa (eye worm) hypothetical protein 0.0117 0.0088 0.0742
Onchocerca volvulus 0.0048 0.0027 0.0864
Loa Loa (eye worm) 6-phosphofructokinase 0.0127 0.0096 0.0812
Entamoeba histolytica phosphofructokinase, putative 0.0127 0.0096 0.1026
Plasmodium falciparum casein kinase II beta chain 0.0043 0.0023 0.0751
Plasmodium vivax 6-phosphofructokinase, putative 0.0034 0.0015 0.0616
Onchocerca volvulus 0.0042 0.0022 0.0705
Trichomonas vaginalis PIKK family atypical protein kinase 0.0927 0.0793 0.8897
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.0016 0.0015
Trichomonas vaginalis CMGC family protein kinase 0.0159 0.0125 0.135
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0302 0.0248 0.2748
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0964 0.0825 0.2371
Trichomonas vaginalis CMGC family protein kinase 0.0159 0.0125 0.135
Plasmodium falciparum GAF domain-related protein, putative 0.0023 0.0005 0.0036
Trichomonas vaginalis PIKK family atypical protein kinase 0.0932 0.0798 0.8951
Entamoeba histolytica hypothetical protein 0.0042 0.0022 0.0193
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0199 0.0159 0.12
Onchocerca volvulus 0.0058 0.0036 0.1143
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0071 0.0048 0.0358
Trypanosoma cruzi hypothetical protein, conserved 0.4005 0.3474 1
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0071 0.0048 0.048
Schistosoma mansoni z-protein (S1r protein) 0.0022 0.0005 0.0037
Trichomonas vaginalis CMGC family protein kinase 0.0159 0.0125 0.135
Loa Loa (eye worm) Csnk2b protein 0.0043 0.0023 0.0192
Loa Loa (eye worm) RGS-3 protein 0.0022 0.0005 0.0042
Trichomonas vaginalis PIKK family atypical protein kinase 0.0199 0.0159 0.1735
Trichomonas vaginalis PIKK family atypical protein kinase 0.0948 0.0811 0.9108
Echinococcus multilocularis expressed conserved protein 0.0095 0.0068 0.0068
Trichomonas vaginalis conserved hypothetical protein 0.0381 0.0318 0.3534
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0302 0.0248 0.0248
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0464 0.039 0.4345
Echinococcus multilocularis beta adrenergic receptor kinase 0.0026 0.0009 0.0008
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0302 0.0248 0.293
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.084 0.0717 0.8046
Trichomonas vaginalis PIKK family atypical protein kinase 0.0953 0.0816 0.9161
Loa Loa (eye worm) hypoxia-induced factor 1 0.0175 0.0138 0.1173
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0766 0.0653 0.0652
Giardia lamblia Kinase, PLK 0.0223 0.018 0.201
Toxoplasma gondii non-specific serine/threonine protein kinase 0.058 0.0491 0.6051
Trichomonas vaginalis PIKK family atypical protein kinase 0.0628 0.0533 0.5962
Schistosoma mansoni serine/threonine protein kinase 0.0374 0.0312 0.2358
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0199 0.0159 0.6322
Loa Loa (eye worm) hypothetical protein 0.019 0.0151 0.1282
Loa Loa (eye worm) hypothetical protein 0.0031 0.0013 0.0107
Trichomonas vaginalis CAMK family protein kinase 0.0223 0.018 0.1977
Trichomonas vaginalis CMGC family protein kinase 0.0159 0.0125 0.135
Schistosoma mansoni serine/threonine protein kinase 0.0026 0.0009 0.0063
Trypanosoma cruzi polo-like protein kinase, putative 0.0223 0.018 0.0513
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0071 0.0048 0.048
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0017 0 0.0000000037793
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0975 0.0835 0.2285
Toxoplasma gondii 6-phosphofructokinase 0.0034 0.0015 0.019
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0374 0.0312 0.2642
Brugia malayi hypoxia-induced factor 1 0.0175 0.0138 0.1553
Schistosoma mansoni cellular tumor antigen P53 0.0058 0.0036 0.027
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0464 0.039 0.4345
Brugia malayi hypothetical protein 0.0022 0.0005 0.0055
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0059 0.0037 0.0281
Trichomonas vaginalis casein kinase II beta chain, putative 0.0043 0.0023 0.02
Echinococcus granulosus expressed protein 0.0435 0.0364 0.0364
Onchocerca volvulus 0.0199 0.0159 0.509
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.0015 0.0014
Echinococcus multilocularis Regulator of G protein signaling 20 0.0022 0.0005 0.0005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0932 0.0798 0.8951
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0086 0.006 0.006
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0037 0.0018 0.0136
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0918 0.0785 0.9401
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0015 0.0117
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0005 0.0003
Brugia malayi Death domain containing protein 0.0017 0 0.0001
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0975 0.0835 1
Brugia malayi Cytochrome P450 family protein 0.0023 0.0005 0.0058
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0022 0.0005 0.0005
Toxoplasma gondii target of rapamycin (TOR), putative 0.0948 0.0811 1
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0034 0.0015 0.5
Brugia malayi Protein kinase domain containing protein 0.0374 0.0312 0.3497
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0493 0.0415 0.4664
Trichomonas vaginalis PIKK family atypical protein kinase 0.0948 0.0811 0.9108
Loa Loa (eye worm) phosphatidylinositol 3 0.0265 0.0217 0.1837
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0031 0.0013 0.0013
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0964 0.0825 0.0825
Schistosoma mansoni hypothetical protein 0.0196 0.0156 0.118
Trichomonas vaginalis CAMK family protein kinase 0.0223 0.018 0.1977
Echinococcus granulosus axis inhibition protein axin 0.0022 0.0005 0.0005
Trichomonas vaginalis casein kinase II beta chain, putative 0.0043 0.0023 0.02
Echinococcus multilocularis Zinc finger, PHD finger 0.0302 0.0248 0.0248
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0975 0.0835 0.9375
Loa Loa (eye worm) hypothetical protein 0.0326 0.027 0.2286
Brugia malayi Cytochrome P450 family protein 0.0035 0.0016 0.0175
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0374 0.0312 0.0311
Entamoeba histolytica hypothetical protein 0.0042 0.0022 0.0193
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0071 0.0048 0.048
Brugia malayi Voltage-dependent L-type calcium channel beta-2 subunit 0.0208 0.0167 0.1874
Schistosoma mansoni 6-phosphofructokinase 0.0127 0.0096 0.0725
Trichomonas vaginalis CAMK family protein kinase 0.0223 0.018 0.1977
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0037 0.0018 0.0018
Loa Loa (eye worm) phosphatidylinositol kinase 0.0199 0.0159 0.1345
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0199 0.0159 0.0451
Loa Loa (eye worm) CYP4Cod1 0.0023 0.0005 0.0044
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0015 0.0117
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0918 0.0785 0.2148
Echinococcus multilocularis protein kinase shaggy 0.0059 0.0037 0.0037
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0059 0.0037 0.0102
Giardia lamblia Phosphatidylinositol 4-kinase 0.0199 0.0159 0.1748
Trichomonas vaginalis PIKK family atypical protein kinase 0.0536 0.0453 0.5057
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0016 0.0193
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0241 0.0196 0.2298
Trichomonas vaginalis PIKK family atypical protein kinase 0.0905 0.0774 0.8687
Entamoeba histolytica casein kinase, putative 0.0159 0.0125 0.135
Trichomonas vaginalis PIKK family atypical protein kinase 0.0905 0.0774 0.8687
Brugia malayi phosphofructokinase 0.0127 0.0096 0.1075
Brugia malayi Intermediate filament tail domain containing protein 0.0031 0.0013 0.0141
Echinococcus granulosus intermediate filament protein 0.0031 0.0013 0.0013
Trichomonas vaginalis PIKK family atypical protein kinase 0.0566 0.0479 0.5354
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.1039 0.089 1
Toxoplasma gondii hypothetical protein 0.0023 0.0005 0.0066
Trichomonas vaginalis casein kinase II beta chain, putative 0.0043 0.0023 0.02
Loa Loa (eye worm) hypothetical protein 0.002 0.0003 0.0022
Trichomonas vaginalis casein kinase II beta chain, putative 0.0043 0.0023 0.02
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0964 0.0825 0.6251
Trypanosoma brucei polo-like protein kinase 0.0223 0.018 0.2107
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0964 0.0825 0.9268
Entamoeba histolytica hypothetical protein 0.0199 0.0159 0.1735
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0517 0.0436 0.4865
Echinococcus multilocularis 0.0199 0.0159 0.0158
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0464 0.039 0.4345
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0023 0.0005 0.0007
Plasmodium vivax hypothetical protein, conserved 0.0199 0.0159 0.6387
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.079 0.0674 0.7551
Brugia malayi regulator of G-protein signaling rgs-7 0.0022 0.0005 0.0055
Brugia malayi M-phase phosphoprotein, mpp8 0.0117 0.0087 0.0981
Echinococcus multilocularis Ankyrin repeat domain containing protein 0.0104 0.0076 0.0076
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0381 0.0318 0.0318
Loa Loa (eye worm) hypothetical protein 0.058 0.0491 0.4165
Loa Loa (eye worm) 6-phosphofructokinase 0.0127 0.0096 0.0812
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0005 0.0044
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0223 0.018 0.1527
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0975 0.0835 0.9372
Brugia malayi 6-phosphofructokinase 0.0127 0.0096 0.1075
Plasmodium falciparum casein kinase II beta chain 0.0043 0.0023 0.0751
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0275 0.0225 0.1911
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0037 0.0018 0.0136
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0059 0.0037 0.0037
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0071 0.0048 0.048
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.055 0.0465 0.5196
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0005 0.0037
Onchocerca volvulus 0.0112 0.0083 0.2661
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0005 0.0044
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.004 0.0394
Echinococcus multilocularis casein kinase ii subunit beta 0.0043 0.0023 0.0023
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0524 0.0442 0.0442
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0199 0.0159 0.0158
Brugia malayi regulator of G-protein signaling egl-10 0.0022 0.0005 0.0055
Loa Loa (eye worm) hypothetical protein 0.0023 0.0005 0.0044
Loa Loa (eye worm) hypothetical protein 0.0022 0.0005 0.0042
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0031 0.0013 0.0089
Trichomonas vaginalis phosphofructokinase, putative 0.0127 0.0096 0.1026
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0302 0.0248 0.0676
Schistosoma mansoni lamin 0.0031 0.0013 0.0095
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0031 0.0013 0.0144
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0026 0.0009 0.0071
Toxoplasma gondii casein kinase ii regulatory subunit protein 0.0043 0.0023 0.0281
Entamoeba histolytica hypothetical protein 0.0042 0.0022 0.0193
Entamoeba histolytica hypothetical protein 0.0199 0.0159 0.1735
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0159 0.0125 0.1056
Mycobacterium ulcerans putative regulatory protein 0.0042 0.0022 0.1861
Loa Loa (eye worm) hypothetical protein 0.0524 0.0442 0.3748
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0199 0.0159 0.1735
Loa Loa (eye worm) hypothetical protein 0.0034 0.0016 0.0131
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0905 0.0774 0.9269
Toxoplasma gondii FATC domain-containing protein 0.0541 0.0457 0.5629
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0005 0.0037
Trypanosoma cruzi casein kinase II, putative 0.0159 0.0125 0.0353
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0876 0.0749 0.8403
Toxoplasma gondii CMGC kinase, CK2 family 0.0159 0.0125 0.1535
Brugia malayi hypothetical protein 0.0117 0.0088 0.0982
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0071 0.0048 0.048
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0071 0.0048 0.048
Echinococcus granulosus cyclin dependent kinase 19 0.0156 0.0121 0.0121
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0034 0.0015 0.0117
Trichomonas vaginalis PIKK family atypical protein kinase 0.0975 0.0835 0.9372
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0071 0.0048 0.048
Entamoeba histolytica hypothetical protein 0.0199 0.0159 0.1735
Echinococcus multilocularis axis inhibition protein axin 0.0022 0.0005 0.0005
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0374 0.0312 0.3497
Echinococcus multilocularis voltage dependent calcium channel 0.0037 0.0018 0.0018
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0037 0.0364
Brugia malayi FAT domain containing protein 0.0381 0.0318 0.357
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0034 0.0015 0.5
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0524 0.0442 0.1267
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0302 0.0248 0.0248
Trichomonas vaginalis phosphofructokinase, putative 0.0127 0.0096 0.1026
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0016 0.0117
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0302 0.0248 0.2788
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0541 0.0457 0.131
Trichomonas vaginalis PIKK family atypical protein kinase 0.0975 0.0835 0.9372
Trichomonas vaginalis PIKK family atypical protein kinase 0.0953 0.0816 0.9161
Trichomonas vaginalis PIKK family atypical protein kinase 0.0905 0.0774 0.8687
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0071 0.0048 0.0131
Trichomonas vaginalis PIKK family atypical protein kinase 0.0975 0.0835 0.9372
Loa Loa (eye worm) hypothetical protein 0.0342 0.0284 0.2406
Trichomonas vaginalis PIKK family atypical protein kinase 0.022 0.0177 0.1945
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0048 0.0028 0.0257
Loa Loa (eye worm) phosphatidylinositol 3 0.0199 0.0159 0.1345
Trichomonas vaginalis set domain proteins, putative 0.0273 0.0224 0.2471
Trichomonas vaginalis casein kinase II beta chain, putative 0.0043 0.0023 0.02
Echinococcus granulosus Ankyrin repeat domain containing protein 0.0104 0.0076 0.0076
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0127 0.0096 0.5907
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0199 0.0159 0.6387
Leishmania major phosphatidylinositol kinase related protein, putative 0.0216 0.0174 0.0471
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0975 0.0835 0.2399
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0601 0.051 0.608
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0541 0.0457 0.5129
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0524 0.0442 0.0442
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0199 0.0159 0.0158
Loa Loa (eye worm) hypothetical protein 0.0396 0.0331 0.2803
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0015 0.0117
Echinococcus granulosus lamin 0.0031 0.0013 0.0013
Brugia malayi intermediate filament protein 0.0031 0.0013 0.0141
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0199 0.0159 0.1849
Trichomonas vaginalis PIKK family atypical protein kinase 0.0953 0.0816 0.9161
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0302 0.0248 0.3061
Echinococcus granulosus high voltage activated calcium channel beta 0.0101 0.0074 0.0073
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0071 0.0048 0.048
Trypanosoma cruzi target of rapamycin kinase 3 0.0953 0.0816 0.2345
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0071 0.0048 0.0509
Brugia malayi hypothetical protein 0.0548 0.0463 0.5202
Plasmodium vivax SET domain protein, putative 0.0034 0.0016 0.0625
Trichomonas vaginalis phosphofructokinase, putative 0.0127 0.0096 0.1026
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0071 0.0048 0.048
Trichomonas vaginalis PIKK family atypical protein kinase 0.0905 0.0774 0.8687
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0037 0.0018 0.0018
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0199 0.0159 0.1955
Loa Loa (eye worm) hypothetical protein 0.0199 0.0159 0.1345
Schistosoma mansoni hypothetical protein 0.0042 0.0022 0.0166
Giardia lamblia Kinase, CMGC CK2 0.0159 0.0125 0.1332
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0464 0.039 0.4345
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0199 0.0159 0.6322
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0302 0.0248 0.188
Brugia malayi intracellular kinase 0.0059 0.0037 0.0418
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0199 0.0159 0.1955
Trichomonas vaginalis PIKK family atypical protein kinase 0.0927 0.0793 0.8897
Echinococcus multilocularis lamin dm0 0.0031 0.0013 0.0013
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0944 0.0808 0.0808
Loa Loa (eye worm) hypothetical protein 0.0766 0.0653 0.5536
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0071 0.0048 0.048
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.1532 0.132 0.132
Plasmodium vivax hypothetical protein, conserved 0.0023 0.0005 0.021
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.079 0.0674 0.7551
Toxoplasma gondii GAF domain-containing protein 0.0023 0.0005 0.0066
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0071 0.0048 0.048
Loa Loa (eye worm) gastrulation defective protein 1 0.0152 0.0118 0.0999
Brugia malayi Casein kinase II, alpha chain 0.0159 0.0125 0.1397
Brugia malayi follicle stimulating hormone receptor 0.0275 0.0225 0.253
Onchocerca volvulus 0.0117 0.0087 0.2803
Schistosoma mansoni serine/threonine protein kinase 0.0026 0.0009 0.0063
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0031 0.0013 0.0089
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0964 0.0825 0.0825
Trichomonas vaginalis PIKK family atypical protein kinase 0.0948 0.0811 0.9108
Schistosoma mansoni transcription factor LCR-F1 0.0042 0.0022 0.0166
Echinococcus multilocularis tumor protein p63 0.0393 0.0328 0.0328
Trichomonas vaginalis PIKK family atypical protein kinase 0.0948 0.0811 0.9108
Schistosoma mansoni high voltage-activated calcium channel beta subunit 2 0.0101 0.0074 0.0556
Echinococcus granulosus survival motor neuron protein 1 0.0548 0.0463 0.0463
Plasmodium vivax 6-phosphofructokinase, putative 0.0034 0.0015 0.0616
Entamoeba histolytica hypothetical protein 0.0876 0.0749 0.8403
Brugia malayi Regulator of G protein signaling domain containing protein 0.0022 0.0005 0.0055
Echinococcus granulosus single minded 2 0.0042 0.0022 0.0022
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0059 0.0037 0.0037
Schistosoma mansoni voltage-gated cation channel 0.0037 0.0018 0.0136
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0127 0.0096 0.0271
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0199 0.0159 0.6387
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0127 0.0096 0.1092
Toxoplasma gondii phosphofructokinase PFKII 0.0034 0.0015 0.019
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0043 0.0023 0.006
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0071 0.0048 0.048
Schistosoma mansoni hypothetical protein 0.0095 0.0068 0.0516
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0071 0.0048 0.048
Mycobacterium leprae conserved hypothetical protein 0.0199 0.0159 1
Trichomonas vaginalis casein kinase II beta chain, putative 0.0043 0.0023 0.02
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.1039 0.089 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0016 0.0117
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0199 0.0159 0.0451
Trypanosoma brucei Casein kinase II subunit beta, putative 0.0043 0.0023 0.0211
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0043 0.0023 0.006
Loa Loa (eye worm) hypothetical protein 0.0022 0.0005 0.0042
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0015 0.0117
Schistosoma mansoni aryl hydrocarbon receptor 0.0057 0.0035 0.0263
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0975 0.0835 1
Trichomonas vaginalis DNA helicase recq, putative 0.0025 0.0007 0.0023
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0199 0.0159 0.178
Echinococcus granulosus geminin 0.0196 0.0156 0.0156
Trypanosoma cruzi polo-like protein kinase, putative 0.0223 0.018 0.0513
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0199 0.0159 0.0158
Loa Loa (eye worm) hypothetical protein 0.0022 0.0005 0.0042
Trichomonas vaginalis CAMK family protein kinase 0.0223 0.018 0.1977
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0071 0.0048 0.0131
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0022 0.0005 0.0005
Schistosoma mansoni serine/threonine protein kinase 0.0156 0.0121 0.0918
Plasmodium vivax glycogen synthase kinase 3, putative 0.0059 0.0037 0.1499
Trichomonas vaginalis casein kinase II beta chain, putative 0.0043 0.0023 0.02
Echinococcus granulosus beta-adrenergic receptor kinase 0.0026 0.0009 0.0008
Giardia lamblia Hypothetical protein 0.0199 0.0159 0.1748
Brugia malayi 6-phosphofructokinase 0.0127 0.0096 0.1075
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0037 0.0018 0.0018
Brugia malayi hypothetical protein 0.0022 0.0005 0.0055
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0059 0.0037 0.0461
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0034 0.0015 0.0117
Trichomonas vaginalis phosphofructokinase, putative 0.0127 0.0096 0.1026
Onchocerca volvulus 0.0059 0.0037 0.1193
Loa Loa (eye worm) hypothetical protein 0.0031 0.0013 0.0109
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0104 0.0076 0.0574
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0071 0.0048 0.048
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.1039 0.089 1
Schistosoma mansoni casein kinase II beta subunit 0.0043 0.0023 0.0171
Echinococcus granulosus casein kinase ii subunit alpha 0.0159 0.0125 0.0124
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0302 0.0248 0.071
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0199 0.0159 0.12
Trichomonas vaginalis PIKK family atypical protein kinase 0.0948 0.0811 0.9108
Brugia malayi hypothetical protein 0.0042 0.0022 0.0247
Brugia malayi SH2 domain containing protein 0.0396 0.0331 0.3711
Trichomonas vaginalis casein kinase II beta chain, putative 0.0043 0.0023 0.02
Trichomonas vaginalis PIKK family atypical protein kinase 0.0927 0.0793 0.8898
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0022 0.0005 0.0037
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.1039 0.089 0.2559
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0381 0.0318 0.0318
Brugia malayi Serotonin receptor 0.0543 0.0459 0.5151
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0022 0.0005 0.0037
Echinococcus granulosus voltage dependent calcium channel 0.0037 0.0018 0.0018
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0059 0.0037 0.0097
Trichomonas vaginalis CAMK family protein kinase 0.0112 0.0083 0.0884
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0071 0.0048 0.048
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.004 0.0394
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0374 0.0312 0.2642
Loa Loa (eye worm) hypothetical protein 0.0017 0 0.0001
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0223 0.018 0.018
Entamoeba histolytica hypothetical protein 0.0042 0.0022 0.0193
Schistosoma mansoni survival motor neuron protein 0.0112 0.0083 0.0628
Trichomonas vaginalis PIKK family atypical protein kinase 0.0325 0.0269 0.2979
Loa Loa (eye worm) hypothetical protein 0.0031 0.0012 0.0103
Leishmania major phosphatidylinositol 4-kinase, putative 0.0199 0.0159 0.043
Plasmodium vivax hypothetical protein 0.0199 0.0159 0.6387
Echinococcus granulosus 6 phosphofructokinase 0.0127 0.0096 0.0096
Echinococcus granulosus regulator of G protein signaling 7 0.0022 0.0005 0.0005
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0005 0.0037
Trichomonas vaginalis casein kinase II beta chain, putative 0.0043 0.0023 0.02
Loa Loa (eye worm) phosphatidylinositol 3 0.137 0.1179 1
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0464 0.039 0.1117
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0043 0.0023 0.0725
Loa Loa (eye worm) calcium channel 0.0037 0.0018 0.0153
Echinococcus granulosus regulator of G protein signaling 3 0.0022 0.0005 0.0005
Entamoeba histolytica protein kinase domain containing protein 0.0059 0.0037 0.0364
Plasmodium falciparum glycogen synthase kinase 3 0.0059 0.0037 0.1348
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0199 0.0159 0.0451
Loa Loa (eye worm) hypothetical protein 0.0022 0.0005 0.0042
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0017 0 0.0001
Echinococcus multilocularis voltage dependent calcium channel 0.0037 0.0018 0.0018
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0043 0.0023 0.02
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0071 0.0048 0.048
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0199 0.0159 0.0451
Entamoeba histolytica protein kinase rad3, putative 0.0524 0.0442 0.4934
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0374 0.0312 0.0311
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0975 0.0835 0.0835
Giardia lamblia Kinase, CMGC GSK 0.0059 0.0037 0.0268
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0034 0.0015 0.019
Trichomonas vaginalis casein kinase II beta chain, putative 0.0043 0.0023 0.02
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.1532 0.132 1
Onchocerca volvulus 0.0031 0.0013 0.0403
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0302 0.0248 0.3061
Echinococcus multilocularis expressed protein 0.0435 0.0364 0.0364
Echinococcus multilocularis musashi 0.0031 0.0013 0.0013
Trichomonas vaginalis PIKK family atypical protein kinase 0.0927 0.0793 0.8897
Trypanosoma brucei Casein kinase II 0.0159 0.0125 0.1438
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0975 0.0835 0.6323
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0265 0.0217 0.0619
Onchocerca volvulus 0.0274 0.0224 0.7187
Trichomonas vaginalis PIKK family atypical protein kinase 0.0524 0.0442 0.4934
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0031 0.0013 0.0089
Echinococcus multilocularis bloom syndrome protein 0.0025 0.0007 0.0007
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0005 0.001
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0015 0.0117
Echinococcus granulosus casein kinase ii subunit beta 0.0043 0.0023 0.0023
Echinococcus multilocularis 6 phosphofructokinase 0.0127 0.0096 0.0096
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0199 0.0159 0.1849
Trichomonas vaginalis CAMK family protein kinase 0.0112 0.0083 0.0884
Echinococcus multilocularis geminin 0.0196 0.0156 0.0156
Trichomonas vaginalis casein kinase II beta chain, putative 0.0043 0.0023 0.02
Schistosoma mansoni hypothetical protein 0.0199 0.0159 0.12
Echinococcus granulosus lamin dm0 0.0031 0.0013 0.0013
Loa Loa (eye worm) phosphofructokinase 0.0127 0.0096 0.0812
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 1.1495 1 1
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0216 0.0174 0.0494
Schistosoma mansoni ankyrin 23/unc44 0.0017 0 0.000000028632
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0524 0.0442 0.4962
Entamoeba histolytica phosphofructokinase, putative 0.0127 0.0096 0.1026
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0071 0.0048 0.0131
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0005 0.0037
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0037 0.0018 0.0018
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0071 0.0048 0.0509
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0048 0.0028 0.0075
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0975 0.0835 0.2399
Schistosoma mansoni intermediate filament proteins 0.0031 0.0013 0.0095
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0964 0.0825 0.2371
Leishmania major phosphatidylinositol 3-kinase, putative 0.0302 0.0248 0.0676
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0059 0.0037 0.0316
Loa Loa (eye worm) intermediate filament protein 0.0031 0.0013 0.0107
Trichomonas vaginalis CMGC family protein kinase 0.0159 0.0125 0.135
Echinococcus granulosus regulator of G protein signaling 7 0.0022 0.0005 0.0005
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0199 0.0159 0.12
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0199 0.0159 0.178
Brugia malayi Pre-SET motif family protein 0.0034 0.0016 0.0174
Loa Loa (eye worm) phosphatidylinositol 3 0.0975 0.0835 0.7082
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0026 0.0009 0.0071
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0101 0.0074 0.0073
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0223 0.018 0.0489
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0016 0.0117
Brugia malayi Protein kinase domain containing protein 0.0156 0.0121 0.1361
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0037 0.0018 0.0018
Brugia malayi Uncoordinated protein 44 0.0017 0 0.0001
Schistosoma mansoni fkbp-rapamycin associated protein 0.0524 0.0442 0.3346
Loa Loa (eye worm) phosphatidylinositol 3 0.0199 0.0159 0.1345
Echinococcus multilocularis serine protein kinase ATM 0.0541 0.0457 0.0457
Leishmania major protein kinase ck2 regulatory subunit, putative 0.0043 0.0023 0.0057
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.1039 0.089 1
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0071 0.0048 0.0047
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0302 0.0248 0.2748
Brugia malayi serine/threonine-protein kinase plk-2 0.0223 0.018 0.2021
Plasmodium vivax casein kinase II beta chain, putative 0.0043 0.0023 0.0913
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0071 0.0048 0.048
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0031 0.0013 0.0097
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0101 0.0074 0.0073
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0026 0.0009 0.0094
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0199 0.0159 0.1735
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0071 0.0048 0.048
Trichomonas vaginalis CAMK family protein kinase 0.0223 0.018 0.1977
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0043 0.0023 0.02
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0037 0.0018 0.0018
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0016 0.0015
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0071 0.0048 0.048
Onchocerca volvulus 0.0031 0.0013 0.0403
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0071 0.0048 0.048
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0022 0.0005 0.0042
Trichomonas vaginalis PIKK family atypical protein kinase 0.0566 0.0479 0.5354
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0071 0.0048 0.0047
Trichomonas vaginalis casein kinase II beta chain, putative 0.0043 0.0023 0.02
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0071 0.0048 0.048
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0048 0.0027 0.0204
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0541 0.0457 0.5442
Toxoplasma gondii hypothetical protein 0.0023 0.0005 0.0066
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0975 0.0835 0.0835
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0627 0.0532 0.6307
Trichomonas vaginalis PIKK family atypical protein kinase 0.0927 0.0793 0.8898
Leishmania major cytochrome p450-like protein 0.0023 0.0005 0.0009
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0127 0.0096 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0199 0.0159 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0953 0.0816 0.9161
Trichomonas vaginalis CAMK family protein kinase 0.0223 0.018 0.1977
Leishmania major ATP-dependent phosphofructokinase 0.0127 0.0096 0.0258
Trichomonas vaginalis PIKK family atypical protein kinase 0.0948 0.0811 0.9108
Leishmania major phosphatidylinositol 3-kinase, putative 0.0905 0.0774 0.2119
Echinococcus multilocularis regulator of G protein signaling 7 0.0022 0.0005 0.0005
Entamoeba histolytica protein kinase domain containing protein 0.0059 0.0037 0.0364
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0017 0 0.0001
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0071 0.0048 0.048
Leishmania major hypothetical protein, unknown function 0.0199 0.0159 0.043
Trichomonas vaginalis DNA helicase recq1, putative 0.0025 0.0007 0.0023
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0302 0.0248 0.2748
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0022 0.0005 0.0037
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0042 0.0022 0.0022
Echinococcus granulosus axis inhibition protein axin 0.0022 0.0005 0.0005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0199 0.0159 0.1735
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0112 0.0083 0.0931
Loa Loa (eye worm) hypothetical protein 0.0022 0.0005 0.0042
Brugia malayi Csnk2b protein 0.0043 0.0023 0.0254
Brugia malayi bHLH-PAS transcription factor 0.0042 0.0022 0.0247
Echinococcus multilocularis casein kinase ii subunit alpha 0.0159 0.0125 0.0124
Onchocerca volvulus 0.0199 0.0159 0.509
Schistosoma mansoni axis inhibition protein axin 0.0022 0.0005 0.0037
Plasmodium vivax unspecified product 0.0159 0.0125 0.5013

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 0.9 mg kg-1 In vivo antinociceptive activity was determined using in rat abdominal irritant test (RAIT) assay ChEMBL. 11300868
Inhibition (functional) = 100 % In vivo antinociceptive activity was determined by mouse abdominal irritant test (MAIT) in male pathogen free albino CD-1 mice ChEMBL. 11300868
Ki (binding) = 0.69 nM In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat ChEMBL. 11300868

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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