Detailed information for compound 291217

Basic information

Technical information
  • TDR Targets ID: 291217
  • Name: 5-[(4-ethylthiophen-3-yl)methyl]-1H-imidazole
  • MW: 192.281 | Formula: C10H12N2S
  • H donors: 1 H acceptors: 1 LogP: 2.5 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1cscc1Cc1c[nH]cn1
  • InChi: 1S/C10H12N2S/c1-2-8-5-13-6-9(8)3-10-4-11-7-12-10/h4-7H,2-3H2,1H3,(H,11,12)
  • InChiKey: FKFWRDSAIVQVAN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-[(4-ethyl-3-thienyl)methyl]-1H-imidazole
  • 4-[(4-ethylthiophen-3-yl)methyl]-3H-imidazole
  • 4-[(4-ethyl-3-thienyl)methyl]-3H-imidazole

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0215 0.0331 0.0949
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0027 0.002 0.0091
Trichomonas vaginalis casein kinase II beta chain, putative 0.0038 0.0039 0.021
Loa Loa (eye worm) hypothetical protein 0.0027 0.002 0.0103
Echinococcus multilocularis neuropeptides capa receptor 0.0027 0.002 0.002
Schistosoma mansoni opsin-like receptor 0.0027 0.002 0.0091
Loa Loa (eye worm) hypothetical protein 0.0027 0.002 0.0103
Loa Loa (eye worm) hypothetical protein 0.0027 0.002 0.0103
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0143 0.0211 0.6382
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.002 0.0009 0.0038
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0015 0 0.0000000064172
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0064 0.0081 0.0503
Loa Loa (eye worm) RecQ helicase 0.0022 0.0012 0.006
Giardia lamblia Kinase, CMGC GSK 0.0053 0.0063 0.0411
Trichomonas vaginalis PIKK family atypical protein kinase 0.0536 0.0861 0.5949
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0027 0.002 0.002
Brugia malayi Melatonin receptor type 1A 0.0027 0.002 0.0139
Echinococcus multilocularis rhodopsin orphan GPCR 0.0027 0.002 0.002
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0122 0.0177 0.1172
Entamoeba histolytica hypothetical protein 0.0038 0.0038 0.0202
Entamoeba histolytica hypothetical protein 0.0122 0.0177 0.1172
Trypanosoma brucei Casein kinase II 0.0143 0.0211 0.2193
Brugia malayi RE15519p 0.0027 0.002 0.0139
Schistosoma mansoni axis inhibition protein axin 0.002 0.0009 0.0038
Trichomonas vaginalis CAMK family protein kinase 0.01 0.0141 0.0927
Echinococcus multilocularis rhodopsin orphan GPCR 0.0027 0.002 0.002
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0038 0.0039 0.021
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0122 0.0177 0.1223
Onchocerca volvulus 0.0027 0.002 0.0378
Echinococcus granulosus biogenic amine 5HT receptor 0.0027 0.002 0.002
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.058 0.0932 0.0931
Schistosoma mansoni neuropeptide receptor 0.0027 0.002 0.0091
Loa Loa (eye worm) hypothetical protein 0.0355 0.0561 0.2881
Loa Loa (eye worm) hypothetical protein 0.0027 0.002 0.0103
Schistosoma mansoni regulator of G protein signaling 0.002 0.0009 0.0038
Onchocerca volvulus 0.0043 0.0046 0.0865
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0064 0.0081 0.0503
Trichomonas vaginalis casein kinase II beta chain, putative 0.0038 0.0039 0.021
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.057 0.0915 0.4179
Loa Loa (eye worm) hypothetical protein 0.0027 0.002 0.0103
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0113 0.0163 1
Trichomonas vaginalis CAMK family protein kinase 0.02 0.0306 0.2074
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.057 0.0915 0.6353
Trichomonas vaginalis CMGC family protein kinase 0.0143 0.0211 0.1416
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0027 0.002 0.0091
Brugia malayi phosphofructokinase 0.0113 0.0163 0.1128
Loa Loa (eye worm) hypothetical protein 0.0027 0.002 0.0103
Trichomonas vaginalis PIKK family atypical protein kinase 0.0556 0.0892 0.6169
Brugia malayi Serotonin receptor 0.0507 0.0812 0.5637
Loa Loa (eye worm) hypothetical protein 0.0027 0.002 0.0103
Echinococcus multilocularis lamin dm0 0.0028 0.0022 0.0021
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.009 0.0125 0.0124
Trichomonas vaginalis CMGC family protein kinase 0.0143 0.0211 0.1416
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0064 0.0081 0.0503
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0027 0.002 0.0091
Schistosoma mansoni regulator of G protein signaling 0.002 0.0009 0.0038
Leishmania major cytochrome p450-like protein 0.002 0.0009 0.0016
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0064 0.0081 0.0503
Echinococcus multilocularis rhodopsin orphan GPCR 0.0027 0.002 0.002
Schistosoma mansoni serine/threonine protein kinase 0.02 0.0306 0.1394
Schistosoma mansoni casein kinase II beta subunit 0.0038 0.0039 0.0175
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0027 0.002 0.0091
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0215 0.0331 0.0331
Echinococcus granulosus allatostatin A receptor 0.0027 0.002 0.002
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0411 0.0654 0.4505
Echinococcus multilocularis neuropeptide s receptor 0.0027 0.002 0.002
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0064 0.0081 0.0503
Echinococcus multilocularis neuropeptides capa receptor 0.0027 0.002 0.002
Brugia malayi hypothetical protein 0.0027 0.002 0.0139
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0064 0.0081 0.0224
Brugia malayi hypothetical protein 0.002 0.0009 0.0058
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0064 0.0081 0.0503
Echinococcus multilocularis Regulator of G protein signaling 20 0.002 0.0009 0.0008
Schistosoma mansoni intermediate filament proteins 0.0028 0.0022 0.0097
Trichomonas vaginalis casein kinase II beta chain, putative 0.0038 0.0039 0.021
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0009 0.0008
Giardia lamblia Kinase, PLK 0.02 0.0306 0.3085
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0027 0.0298
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0033 0.0031 0.003
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0027 0.0026
Trichomonas vaginalis CAMK family protein kinase 0.02 0.0306 0.2074
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0122 0.0177 0.1172
Echinococcus multilocularis high voltage activated calcium channel beta 0.009 0.0125 0.0125
Echinococcus granulosus voltage dependent calcium channel 0.0033 0.0031 0.003
Loa Loa (eye worm) hypothetical protein 0.0027 0.002 0.0103
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0031 0.0026 0.0123
Brugia malayi hypothetical protein 0.0027 0.002 0.0139
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.058 0.0932 0.0931
Schistosoma mansoni amine GPCR 0.0027 0.002 0.0091
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0064 0.0081 0.0503
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0888 0.1441 0.4161
Loa Loa (eye worm) hypothetical protein 0.0027 0.002 0.0103
Brugia malayi Uncoordinated protein 44 0.0015 0 0.0001
Echinococcus granulosus tumor protein p63 0.0353 0.0557 0.0557
Brugia malayi Csnk2b protein 0.0038 0.0039 0.0266
Schistosoma mansoni biogenic amine receptor 0.0027 0.002 0.0091
Echinococcus multilocularis orexin receptor type 2 0.0027 0.002 0.002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0342 0.054 0.3709
Echinococcus granulosus g-protein coupled receptor 0.0027 0.002 0.002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0141 0.0208 0.1392
Echinococcus multilocularis serotonin receptor 0.0027 0.002 0.002
Schistosoma mansoni biogenic amine receptor 0.0027 0.002 0.0091
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.058 0.0932 0.2688
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0033 0.0031 0.0139
Loa Loa (eye worm) PXA domain-containing protein 0.0021 0.0011 0.0055
Brugia malayi putative neuropeptide receptor 0.0027 0.002 0.0139
Brugia malayi intermediate filament protein 0.0028 0.0022 0.0148
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0766 0.124 0.8597
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0064 0.0081 0.0503
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0043 0.0046 0.0209
Trichomonas vaginalis conserved hypothetical protein 0.0335 0.0529 0.3632
Brugia malayi ORL1-like opioid receptor 0.0027 0.002 0.0139
Echinococcus granulosus somatostatin receptor 0.0027 0.002 0.002
Trichomonas vaginalis phosphofructokinase, putative 0.0113 0.0163 0.1076
Loa Loa (eye worm) hypothetical protein 0.0027 0.002 0.0103
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0064 0.0081 0.0503
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0038 0.0039 0.0725
Loa Loa (eye worm) 6-phosphofructokinase 0.0113 0.0163 0.0835
Schistosoma mansoni hypothetical protein 0.0175 0.0265 0.1208
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.6076 1 1
Schistosoma mansoni neuropeptide receptor 0.0027 0.002 0.0091
Loa Loa (eye worm) hypothetical protein 0.0028 0.0022 0.011
Brugia malayi Protein kinase domain containing protein 0.014 0.0206 0.1427
Brugia malayi hypothetical protein 0.0027 0.002 0.0139
Schistosoma mansoni serine/threonine protein kinase 0.014 0.0206 0.0939
Schistosoma mansoni regulator of G protein signaling 0.002 0.0009 0.0038
Leishmania major phosphatidylinositol 4-kinase, putative 0.0122 0.0177 0.0474
Trypanosoma brucei protein kinase, putative 0.0053 0.0063 0.0589
Onchocerca volvulus 0.0028 0.0022 0.0403
Trichomonas vaginalis PIKK family atypical protein kinase 0.0122 0.0177 0.1172
Toxoplasma gondii GAF domain-containing protein 0.002 0.0009 0.0102
Echinococcus granulosus orexin receptor type 2 0.0027 0.002 0.002
Brugia malayi hypothetical protein 0.0027 0.002 0.0139
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0215 0.0331 0.2251
Schistosoma mansoni opsin-like receptor 0.0027 0.002 0.0091
Loa Loa (eye worm) hypothetical protein 0.0027 0.0021 0.0106
Loa Loa (eye worm) hypothetical protein 0.0027 0.002 0.0103
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0022 0.011
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0335 0.0529 0.3667
Loa Loa (eye worm) cytochrome P450 family protein 0.002 0.0009 0.0045
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0214 0.0328 0.0327
Trypanosoma cruzi polo-like protein kinase, putative 0.02 0.0306 0.0875
Loa Loa (eye worm) hypothetical protein 0.0638 0.1029 0.5288
Mycobacterium tuberculosis Conserved hypothetical protein 0.0122 0.0177 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0043
Schistosoma mansoni hypothetical protein 0.01 0.0141 0.0642
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.002 0.0009 0.0008
Brugia malayi hypothetical protein 0.002 0.0009 0.0058
Trichomonas vaginalis CMGC family protein kinase 0.0143 0.0211 0.1416
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0043
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0026 0.0573
Trichomonas vaginalis casein kinase II beta chain, putative 0.0038 0.0039 0.021
Entamoeba histolytica phosphofructokinase, putative 0.0113 0.0163 0.1076
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0304 0.0477 0.3307
Plasmodium vivax SET domain protein, putative 0.0031 0.0027 0.0796
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0053 0.0063 0.0063
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0638 0.1029 0.1029
Loa Loa (eye worm) hypothetical protein 0.0027 0.002 0.0103
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0335 0.0529 0.0528
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0122 0.0177 0.0502
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0033 0.0031 0.003
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0027 0.002 0.002
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0064 0.0081 0.008
Trichomonas vaginalis casein kinase II beta chain, putative 0.0038 0.0039 0.021
Brugia malayi Dopamine receptor protein 2 0.0027 0.002 0.0139
Brugia malayi G-protein coupled receptor 0.0027 0.002 0.0139
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0009 0.0008
Schistosoma mansoni ankyrin 23/unc44 0.0015 0 0.000000029301
Echinococcus multilocularis G protein coupled receptor 139 0.0027 0.002 0.002
Brugia malayi PXA domain containing protein 0.0021 0.0011 0.0075
Trichomonas vaginalis PIKK family atypical protein kinase 0.0556 0.0892 0.6169
Schistosoma mansoni lamin 0.0028 0.0022 0.0097
Plasmodium vivax hypothetical protein 0.0122 0.0177 0.5328
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0027 0.002 0.0091
Echinococcus granulosus serine protein kinase ATM 0.0319 0.0502 0.0502
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0215 0.0331 0.3711
Echinococcus multilocularis lamin 0.0028 0.0022 0.0021
Giardia lamblia Casein kinase II beta chain 0.0038 0.0039 0.0138
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.1342 0.219 0.219
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0009 0.0038
Brugia malayi G protein-coupled receptor F59B2.13 0.0027 0.002 0.0139
Entamoeba histolytica phosphofructokinase, putative 0.0113 0.0163 0.1076
Loa Loa (eye worm) CMGC/CDK/CDK8 protein kinase 0.014 0.0206 0.1057
Schistosoma mansoni lamin 0.0028 0.0022 0.0097
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0215 0.0331 1
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.016 0.024 0.25
Brugia malayi bHLH-PAS transcription factor 0.0038 0.0038 0.0259
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0027 0.002 0.002
Toxoplasma gondii casein kinase ii regulatory subunit protein 0.0038 0.0039 0.0434
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0027 0.002 0.0091
Onchocerca volvulus 0.01 0.0141 0.2663
Trichomonas vaginalis set domain proteins, putative 0.0245 0.038 0.2594
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0068 0.0413
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0197 0.0301 0.0862
Loa Loa (eye worm) G-protein coupled receptor 0.0027 0.002 0.0103
Loa Loa (eye worm) hypothetical protein 0.0027 0.002 0.0103
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0053 0.0063 0.0324
Giardia lamblia Kinase, CMGC GSK 0.0053 0.0063 0.0411
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0122 0.0177 0.0176
Loa Loa (eye worm) calcium channel 0.0033 0.0031 0.0157
Brugia malayi regulator of G-protein signaling rgs-7 0.002 0.0009 0.0058
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0319 0.0502 0.5342
Echinococcus multilocularis casein kinase ii subunit beta 0.0038 0.0039 0.0038
Loa Loa (eye worm) phosphatidylinositol 3 0.1194 0.1946 1
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0009 0.0008
Echinococcus granulosus G protein coupled receptor 139 0.0027 0.002 0.002
Entamoeba histolytica hypothetical protein 0.0319 0.0502 0.3444
Plasmodium vivax casein kinase II beta chain, putative 0.0038 0.0039 0.1161
Schistosoma mansoni growth hormone secretagogue receptor 0.0027 0.002 0.0091
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0009 0.0058
Loa Loa (eye worm) Csnk2b protein 0.0038 0.0039 0.0197
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0027 0.002 0.0139
Loa Loa (eye worm) hypothetical protein 0.0027 0.002 0.0103
Trypanosoma cruzi target of rapamycin kinase 3 0.056 0.09 0.2596
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0027 0.002 0.0103
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0122 0.0177 0.5222
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0064 0.0081 0.0224
Schistosoma mansoni survival motor neuron protein 0.01 0.0141 0.0642
Onchocerca volvulus 0.0027 0.002 0.0378
Echinococcus granulosus alpha 1A adrenergic receptor 0.0027 0.002 0.002
Entamoeba histolytica protein kinase domain containing protein 0.0053 0.0063 0.0382
Echinococcus multilocularis voltage dependent calcium channel 0.0033 0.0031 0.003
Plasmodium vivax hypothetical protein, conserved 0.002 0.0009 0.0267
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0023
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0364 0.0576 0.396
Brugia malayi Death domain containing protein 0.0015 0 0.0001
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0888 0.1441 0.4161
Onchocerca volvulus 0.0027 0.002 0.0378
Trichomonas vaginalis PIKK family atypical protein kinase 0.0556 0.0892 0.6169
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0304 0.0477 0.0476
Plasmodium vivax unspecified product 0.0143 0.0211 0.6382
Leishmania major ATP-dependent phosphofructokinase 0.0113 0.0163 0.0436
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0033 0.0031 0.003
Brugia malayi hypothetical protein 0.0027 0.002 0.0139
Echinococcus granulosus sex peptide receptor 0.0027 0.002 0.002
Echinococcus granulosus tm gpcr rhodopsin 0.0027 0.002 0.002
Onchocerca volvulus 0.0027 0.002 0.0378
Plasmodium falciparum casein kinase II beta chain 0.0038 0.0039 0.096
Loa Loa (eye worm) phosphatidylinositol 3 0.0122 0.0177 0.0906
Brugia malayi intracellular kinase 0.0053 0.0063 0.0438
Entamoeba histolytica protein kinase domain containing protein 0.0143 0.0211 0.1416
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0027 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0027 0.002 0.0103
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0027 0.002 0.002
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0064 0.0081 0.0503
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.02 0.0306 0.0827
Loa Loa (eye worm) hypothetical protein 0.0027 0.002 0.0103
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0038 0.0039 0.0725
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0888 0.1441 1
Leishmania major phosphatidylinositol 3-kinase, putative 0.0215 0.0331 0.0897
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0122 0.0177 0.5328
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0053 0.0063 0.0165
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0028 0.0022 0.0151
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0064 0.0081 0.0503
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0093 0.0129 0.0588
Loa Loa (eye worm) 6-phosphofructokinase 0.0113 0.0163 0.0835
Echinococcus granulosus dro:myosuppressin receptor 0.0027 0.002 0.002
Echinococcus multilocularis g protein coupled receptor 0.0027 0.002 0.002
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0026 0.0123
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0053 0.0063 0.0711
Echinococcus granulosus 7tm_1 domain containing protein 0.0027 0.002 0.002
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0122 0.0177 0.0502
Trichomonas vaginalis casein kinase II beta chain, putative 0.0038 0.0039 0.021
Trichomonas vaginalis casein kinase II beta chain, putative 0.0038 0.0039 0.021
Trypanosoma brucei Casein kinase II subunit beta, putative 0.0038 0.0039 0.0322
Loa Loa (eye worm) hypothetical protein 0.0027 0.002 0.0103
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0888 0.1441 1
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0026 0.0783
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0043
Trichomonas vaginalis CMGC family protein kinase 0.0143 0.0211 0.1416
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0064 0.0081 0.0777
Echinococcus multilocularis expressed conserved protein 0.0085 0.0116 0.0116
Schistosoma mansoni neuropeptide f receptor 76f 0.0027 0.002 0.0091
Echinococcus granulosus peptide allatostatin:somatostatin 0.0027 0.002 0.002
Entamoeba histolytica phosphofructokinase, putative 0.0113 0.0163 0.1076
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0064 0.0081 0.0224
Brugia malayi Pre-SET motif family protein 0.0031 0.0027 0.0183
Trichomonas vaginalis casein kinase II beta chain, putative 0.0038 0.0039 0.021
Mycobacterium ulcerans putative regulatory protein 0.002 0.0009 0.0007
Onchocerca volvulus Serine\/threonine kinase homolog 0.02 0.0306 0.5778
Echinococcus granulosus hypothetical protein 0.0027 0.002 0.002
Onchocerca volvulus 0.0027 0.002 0.0378
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0122 0.0177 0.1979
Mycobacterium leprae conserved hypothetical protein 0.0122 0.0177 1
Loa Loa (eye worm) phosphatidylinositol 3 0.058 0.0932 0.4788
Brugia malayi PAS domain containing protein 0.0051 0.0059 0.041
Echinococcus multilocularis neuropeptide FF receptor 2 0.0027 0.002 0.002
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0026 0.0783
Loa Loa (eye worm) hypothetical protein 0.0015 0.0001 0.0001
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0027 0.002 0.002
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0009 0.0003
Mycobacterium ulcerans putative regulatory protein 0.002 0.0009 0.0007
Schistosoma mansoni hypothetical protein 0.0027 0.002 0.0091
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0038 0.017
Loa Loa (eye worm) hypothetical protein 0.0027 0.002 0.0103
Echinococcus granulosus rhodopsin orphan GPCR 0.0027 0.002 0.002
Trichomonas vaginalis PIKK family atypical protein kinase 0.056 0.09 0.6225
Trichomonas vaginalis PIKK family atypical protein kinase 0.0315 0.0495 0.3397
Loa Loa (eye worm) hypothetical protein 0.0028 0.0022 0.0112
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.058 0.0932 0.6446
Schistosoma mansoni biogenic amine (5HT) receptor 0.0027 0.002 0.0091
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.057 0.0915 0.0915
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0027 0.002 0.0091
Brugia malayi hypothetical protein 0.0105 0.0149 0.1031
Loa Loa (eye worm) hypothetical protein 0.0027 0.002 0.0103
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.002 0.0009 0.0007
Leishmania major phosphatidylinositol kinase related protein, putative 0.0137 0.0202 0.0543
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0113 0.0163 0.0462
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0063 0.0382
Schistosoma mansoni voltage-gated cation channel 0.0033 0.0031 0.0139
Loa Loa (eye worm) phosphatidylinositol 3 0.0528 0.0847 0.4354
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0027 0.002 0.002
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0027 0.012
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0364 0.0576 0.396
Echinococcus granulosus high voltage activated calcium channel beta 0.009 0.0125 0.0125
Trichomonas vaginalis casein kinase II beta chain, putative 0.0038 0.0039 0.021
Brugia malayi Tachykinin-like peptides receptor 99D 0.0027 0.002 0.0139
Loa Loa (eye worm) hypothetical protein 0.0027 0.002 0.0103
Toxoplasma gondii hypothetical protein 0.002 0.0009 0.0102
Leishmania major casein kinase II, putative 0.0143 0.0211 0.0569
Entamoeba histolytica protein kinase, putative 0.0053 0.0063 0.0382
Trichomonas vaginalis PIKK family atypical protein kinase 0.0556 0.0892 0.6169
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0027 0.002 0.002
Echinococcus granulosus lamin 0.0028 0.0022 0.0021
Leishmania major hypothetical protein, unknown function 0.0122 0.0177 0.0474
Echinococcus granulosus g protein coupled receptor 0.0027 0.002 0.002
Echinococcus granulosus cyclin dependent kinase 19 0.014 0.0206 0.0206
Loa Loa (eye worm) phosphatidylinositol kinase 0.0122 0.0177 0.0906
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0038 0.0039 0.0103
Echinococcus granulosus neuropeptide receptor A26 0.0027 0.002 0.002
Brugia malayi Cytochrome P450 family protein 0.002 0.0009 0.006
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0043
Brugia malayi Pre-SET motif family protein 0.0215 0.0331 0.2296
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0335 0.0529 0.2715
Brugia malayi hypoxia-induced factor 1 0.0157 0.0235 0.1628
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0113 0.0163 0.1666
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0064 0.0081 0.0503
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0027 0.0026
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0033 0.0031 0.0212
Loa Loa (eye worm) hypothetical protein 0.0027 0.002 0.0103
Trichomonas vaginalis PIKK family atypical protein kinase 0.0536 0.086 0.5948
Loa Loa (eye worm) hypothetical protein 0.0214 0.0328 0.1684
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0122 0.0177 0.1172
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0009 0.0008
Loa Loa (eye worm) hypothetical protein 0.0027 0.002 0.0103
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0064 0.0081 0.0503
Loa Loa (eye worm) hypothetical protein 0.0122 0.0177 0.0906
Loa Loa (eye worm) hypothetical protein 0.0027 0.002 0.0103
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0064 0.0081 0.0503
Echinococcus granulosus rhodopsin orphan GPCR 0.0027 0.002 0.002
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.1342 0.219 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0517 0.0829 0.5728
Loa Loa (eye worm) hypothetical protein 0.0027 0.002 0.0103
Trypanosoma brucei target of rapamycin kinase 3, putative 0.056 0.09 0.9658
Trypanosoma cruzi cytochrome P450, putative 0.002 0.0009 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0517 0.0829 0.5728
Schistosoma mansoni serine/threonine protein kinase 0.0024 0.0014 0.0064
Echinococcus granulosus beta-adrenergic receptor kinase 0.0024 0.0014 0.0014
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0027 0.002 0.002
Echinococcus multilocularis survival motor neuron protein 1 0.0491 0.0786 0.0786
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0009 0.0008
Brugia malayi SH2 domain containing protein 0.0355 0.0561 0.3891
Echinococcus granulosus axis inhibition protein axin 0.002 0.0009 0.0008
Schistosoma mansoni opsin-like receptor 0.0027 0.002 0.0091
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0093 0.0129 0.0588
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0846 0.1371 0.1371
Echinococcus multilocularis cyclin dependent kinase 19 0.014 0.0206 0.0206
Echinococcus multilocularis 6 phosphofructokinase 0.0113 0.0163 0.0162
Schistosoma mansoni hypothetical protein 0.0175 0.0265 0.1208
Trichomonas vaginalis conserved hypothetical protein 0.0214 0.0328 0.2229
Mycobacterium ulcerans putative regulatory protein 0.0038 0.0038 0.1861
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0122 0.0177 0.0176
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0027 0.002 0.0091
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0043 0.0047 0.0127
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.058 0.0932 1
Loa Loa (eye worm) melatonin receptor type 1A 0.0027 0.002 0.0103
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0064 0.0081 0.0503
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0027 0.002 0.0139
Trichomonas vaginalis PIKK family atypical protein kinase 0.0366 0.058 0.3986
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.009 0.0125 0.0124
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0064 0.0081 0.0503
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0031 0.0026 0.0123
Echinococcus multilocularis serine protein kinase ATM 0.0319 0.0502 0.0502
Echinococcus granulosus fmrfamide receptor 0.0027 0.002 0.002
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.058 0.0932 0.254
Echinococcus multilocularis Zinc finger, PHD finger 0.0215 0.0331 0.0331
Toxoplasma gondii CMGC kinase, CK2 family 0.0143 0.0211 0.2369
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0022 0.011
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0028 0.0022 0.0093
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0143 0.0211 0.1085
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0335 0.0529 1
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0031 0.0026 0.5
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0215 0.0331 0.2251
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0043
Echinococcus granulosus neuropeptide receptor 0.0027 0.002 0.002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0342 0.054 0.3709
Schistosoma mansoni alpha-1 adrenergic receptor 0.0027 0.002 0.0091
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0113 0.0163 0.9178
Echinococcus multilocularis rhodopsin orphan GPCR 0.0027 0.002 0.002
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0215 0.0331 0.17
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0053 0.0063 0.0288
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0304 0.0477 0.137
Loa Loa (eye worm) hypothetical protein 0.0033 0.0031 0.0157
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0027 0.0026
Toxoplasma gondii 6-phosphofructokinase 0.0031 0.0026 0.0294
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.074 0.1196 0.8292
Brugia malayi follicle stimulating hormone receptor 0.0267 0.0416 0.2888
Loa Loa (eye worm) neuropeptide F receptor 0.0027 0.002 0.0103
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0027 0.002 0.0091
Trichomonas vaginalis CMGC family protein kinase 0.0143 0.0211 0.1416
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0064 0.0081 0.0777
Loa Loa (eye worm) hypothetical protein 0.0027 0.002 0.0103
Loa Loa (eye worm) CYP4Cod1 0.002 0.0009 0.0045
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0015 0.0001 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0182 0.0276 0.1866
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0641 0.1033 0.7169
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0064 0.0081 0.008
Loa Loa (eye worm) phosphatidylinositol 3 0.0242 0.0375 0.1925
Loa Loa (eye worm) hypothetical protein 0.0019 0.0007 0.0035
Echinococcus granulosus g protein coupled receptor 0.0027 0.002 0.002
Echinococcus multilocularis neuropeptide receptor A26 0.0027 0.002 0.002
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0528 0.0847 0.2309
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0364 0.0576 0.1657
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.058 0.0932 0.254
Trichomonas vaginalis PIKK family atypical protein kinase 0.058 0.0932 0.6446
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0364 0.0576 0.396
Trichomonas vaginalis PIKK family atypical protein kinase 0.0536 0.086 0.5948
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0026 0.0123
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0122 0.0177 0.0804
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0027 0.002 0.0103
Brugia malayi Protein kinase domain containing protein 0.0335 0.0529 0.3667
Loa Loa (eye worm) hypothetical protein 0.0027 0.002 0.0103
Trichomonas vaginalis PIKK family atypical protein kinase 0.0122 0.0177 0.1172
Echinococcus granulosus casein kinase ii subunit alpha 0.0143 0.0211 0.0211
Echinococcus granulosus single minded 2 0.0038 0.0038 0.0037
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0064 0.0081 0.0503
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0122 0.0177 0.0804
Onchocerca volvulus 0.0105 0.0149 0.2806
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0027 0.002 0.0091
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0064 0.0081 0.0503
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0528 0.0847 0.9086
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0027 0.002 0.0091
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0122 0.0177 0.5328
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0122 0.0177 0.1223
Onchocerca volvulus 0.0027 0.002 0.0378
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0028 0.0022 0.0093
Mycobacterium ulcerans 6-phosphofructokinase 0.0113 0.0163 1
Echinococcus multilocularis serotonin receptor 0.0027 0.002 0.002
Echinococcus multilocularis fmrfamide receptor 0.0027 0.002 0.002
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0122 0.0177 0.0502
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0068 0.0413
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0027 0.002 0.0091
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0335 0.0529 0.0528
Trichomonas vaginalis casein kinase II beta chain, putative 0.0038 0.0039 0.021
Brugia malayi regulator of G-protein signaling egl-10 0.002 0.0009 0.0058
Echinococcus granulosus expressed protein 0.0389 0.0618 0.0618
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0064 0.0081 0.0503
Entamoeba histolytica protein kinase domain containing protein 0.0053 0.0063 0.0382
Brugia malayi Bloom's syndrome protein homolog 0.0022 0.0012 0.0082
Brugia malayi A-kinase anchor protein 10, precursor 0.002 0.0009 0.0058
Loa Loa (eye worm) hypothetical protein 0.0027 0.002 0.0103
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.01 0.0141 0.0977
Onchocerca volvulus 0.0027 0.002 0.0378
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0027 0.002 0.002
Trichomonas vaginalis casein kinase II beta chain, putative 0.0038 0.0039 0.021
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0027 0.002 0.0378
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0028 0.0022 0.0151
Echinococcus granulosus casein kinase ii subunit beta 0.0038 0.0039 0.0038
Echinococcus multilocularis musashi 0.0028 0.0022 0.0021
Schistosoma mansoni neuropeptide F-like receptor 0.0027 0.002 0.0091
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0027 0.002 0.002
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0215 0.0331 0.2251
Loa Loa (eye worm) hypothetical protein 0.0491 0.0786 0.4041
Onchocerca volvulus 0.0105 0.0149 0.2806
Echinococcus granulosus Ankyrin repeat domain containing protein 0.0093 0.0129 0.0129
Echinococcus multilocularis fmrfamide receptor 0.0027 0.002 0.002
Echinococcus granulosus rhodopsin orphan GPCR 0.0027 0.002 0.002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0304 0.0477 0.3268
Trichomonas vaginalis PIKK family atypical protein kinase 0.0517 0.0829 0.5728
Trypanosoma cruzi casein kinase II, putative 0.0143 0.0211 0.0602
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0335 0.0529 0.5927
Loa Loa (eye worm) gastrulation defective protein 1 0.0136 0.02 0.1027
Brugia malayi sulfakinin receptor protein 0.0027 0.002 0.0139
Loa Loa (eye worm) hypothetical protein 0.0335 0.0529 0.2716
Trichomonas vaginalis casein kinase II beta chain, putative 0.0038 0.0039 0.021
Schistosoma mansoni hypothetical protein 0.0027 0.002 0.0091
Trichomonas vaginalis phosphofructokinase, putative 0.0113 0.0163 0.1076
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0214 0.0328 0.0327
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0033 0.0031 0.003
Trichomonas vaginalis CAMK family protein kinase 0.02 0.0306 0.2074
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0027 0.002 0.0091
Loa Loa (eye worm) hypothetical protein 0.0027 0.002 0.0103
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0638 0.1029 0.1029
Brugia malayi putative neuropeptide receptor NPR1 0.0027 0.002 0.0139
Brugia malayi neuropeptide F receptor 0.0027 0.002 0.0139
Schistosoma mansoni 6-phosphofructokinase 0.0113 0.0163 0.0741
Loa Loa (eye worm) hypothetical protein 0.0027 0.002 0.0103
Plasmodium falciparum casein kinase II beta chain 0.0038 0.0039 0.096
Brugia malayi G-protein coupled receptor 0.0027 0.002 0.0139
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0888 0.1441 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0027 0.002 0.002
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0028 0.0022 0.0099
Brugia malayi GnHR receptor homolog 0.0027 0.002 0.0139
Brugia malayi hypothetical protein 0.0027 0.002 0.0139
Trichomonas vaginalis PIKK family atypical protein kinase 0.0536 0.0861 0.5949
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0122 0.0177 0.1979
Loa Loa (eye worm) phosphofructokinase 0.0113 0.0163 0.0835
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0414 0.0658 0.3002
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0022 0.0148
Brugia malayi serine/threonine-protein kinase plk-2 0.02 0.0306 0.2119
Trichomonas vaginalis PIKK family atypical protein kinase 0.0347 0.0548 0.3765
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0027 0.002 0.0091
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0027 0.012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0536 0.086 0.5948
Echinococcus multilocularis bloom syndrome protein 0.0022 0.0012 0.0012
Trichomonas vaginalis PIKK family atypical protein kinase 0.058 0.0932 0.6446
Trichomonas vaginalis PIKK family atypical protein kinase 0.058 0.0932 0.6446
Brugia malayi Voltage-dependent L-type calcium channel beta-2 subunit 0.0186 0.0283 0.1965
Schistosoma mansoni protein kinase 0.0143 0.0211 0.0963
Entamoeba histolytica hypothetical protein 0.0038 0.0038 0.0202
Brugia malayi Cytochrome P450 family protein 0.002 0.0009 0.006
Entamoeba histolytica hypothetical protein 0.0038 0.0038 0.0202
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0026 0.0123
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0215 0.0331 0.0897
Loa Loa (eye worm) hypothetical protein 0.0297 0.0466 0.2391
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0064 0.0081 0.0503
Plasmodium vivax casein kinase II beta chain, putative 0.0038 0.0039 0.1161
Loa Loa (eye worm) hypothetical protein 0.0027 0.002 0.0103
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.058 0.0932 0.2688
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0215 0.0331 0.151
Giardia lamblia GTOR 0.058 0.0932 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0027 0.002 0.002
Echinococcus granulosus 7TM GPCR rhodopsin 0.0027 0.002 0.002
Loa Loa (eye worm) voltage-dependent calcium channel beta 2a subunit 0.0186 0.0283 0.1455
Echinococcus multilocularis 0.0122 0.0177 0.0176
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.02 0.0306 0.0305
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0028 0.0022 0.0022
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.0004 0.0018
Echinococcus granulosus protein kinase shaggy 0.0053 0.0063 0.0063
Schistosoma mansoni neuropeptide receptor 0.0027 0.002 0.0091
Brugia malayi hypothetical protein 0.0027 0.002 0.0139
Echinococcus granulosus tachykinin peptides receptor 99D 0.0027 0.002 0.002
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0027 0.002 0.0091
Echinococcus multilocularis casein kinase ii subunit alpha 0.0143 0.0211 0.0211
Onchocerca volvulus 0.0053 0.0063 0.1193
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0024 0.0014 0.0073
Onchocerca volvulus Neuropeptide F receptor homolog 0.0027 0.002 0.0378
Brugia malayi Dopamine receptor protein 1 0.0027 0.002 0.0139
Trichomonas vaginalis PIKK family atypical protein kinase 0.0536 0.0861 0.5949
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0031 0.0026 0.0294
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0122 0.0177 0.5222
Trichomonas vaginalis CAMK family protein kinase 0.02 0.0306 0.2074
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0033 0.0031 0.003
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0009 0.0008
Brugia malayi 6-phosphofructokinase 0.0113 0.0163 0.1128
Onchocerca volvulus 0.0122 0.0177 0.3334
Echinococcus multilocularis geminin 0.0175 0.0265 0.0265
Loa Loa (eye worm) hypoxia-induced factor 1 0.0157 0.0235 0.1205
Onchocerca volvulus 0.0027 0.002 0.0378
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0077 0.0102 0.0102
Trichomonas vaginalis PIKK family atypical protein kinase 0.056 0.09 0.6225
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0025 0.0024
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0319 0.0502 0.3482
Echinococcus granulosus bloom syndrome protein 0.0022 0.0012 0.0012
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0319 0.0502 0.229
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0053 0.0063 0.0324
Echinococcus multilocularis dro:myosuppressin receptor 0.0027 0.002 0.002
Trichomonas vaginalis casein kinase II beta chain, putative 0.0038 0.0039 0.021
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0027 0.002 0.0091
Echinococcus granulosus g protein coupled receptor 0.0027 0.002 0.002
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0027 0.002 0.0091
Onchocerca volvulus 0.0052 0.0061 0.1143
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0122 0.0177 0.1815
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0026 0.0573
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0335 0.0529 0.2715
Trichomonas vaginalis PIKK family atypical protein kinase 0.056 0.09 0.6225
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.027 0.0421 0.4362
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.056 0.09 0.2454
Echinococcus multilocularis g protein coupled receptor 0.0027 0.002 0.002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0541 0.0869 0.6005
Echinococcus multilocularis voltage dependent calcium channel 0.0033 0.0031 0.003
Schistosoma mansoni histamine h1 receptor 0.0027 0.002 0.0091
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0027 0.002 0.002
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.058 0.0932 0.4253
Echinococcus multilocularis neuropeptide receptor 0.0027 0.002 0.002
Loa Loa (eye worm) cytochrome P450 family protein 0.0031 0.0027 0.0136
Onchocerca volvulus 0.0027 0.002 0.0378
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0122 0.0177 0.1815
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0027 0.002 0.0091
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0027 0.002 0.0139
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.02 0.0306 0.1569
Loa Loa (eye worm) hypothetical protein 0.0304 0.0477 0.2449
Loa Loa (eye worm) cytochrome P450 family protein 0.002 0.0009 0.0045
Echinococcus granulosus neuropeptide Y receptor 0.0027 0.002 0.002
Brugia malayi Casein kinase II, alpha chain 0.0143 0.0211 0.1465
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0512 0.0821 0.8776
Echinococcus granulosus survival motor neuron protein 1 0.0491 0.0786 0.0786
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0267 0.0416 0.2138
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0064 0.0081 0.0503
Schistosoma mansoni z-protein (S1r protein) 0.002 0.0009 0.0038
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0026 0.0123
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0661 0.1066 0.738
Echinococcus multilocularis sex peptide receptor 0.0027 0.002 0.002
Loa Loa (eye worm) TYRA-2 protein 0.0027 0.002 0.0103
Giardia lamblia Phosphatidylinositol 4-kinase 0.0122 0.0177 0.166
Trichomonas vaginalis CAMK family protein kinase 0.02 0.0306 0.2074
Trichomonas vaginalis PIKK family atypical protein kinase 0.056 0.09 0.6225
Brugia malayi Serotonin receptor 0.0027 0.002 0.0139
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0027 0.002 0.002
Loa Loa (eye worm) phosphatidylinositol 3 0.0122 0.0177 0.0906
Echinococcus multilocularis regulator of G protein signaling 0.002 0.0009 0.0008
Trichomonas vaginalis casein kinase II beta chain, putative 0.0038 0.0039 0.021
Loa Loa (eye worm) hypothetical protein 0.0027 0.002 0.0103
Entamoeba histolytica hypothetical protein 0.0122 0.0177 0.1172
Leishmania major phosphatidylinositol kinase, putative 0.0122 0.0177 0.0474
Trichomonas vaginalis CAMK family protein kinase 0.02 0.0306 0.2074
Leishmania major phosphatidylinositol 3-kinase, putative 0.0517 0.0829 0.2259
Echinococcus granulosus neuropeptide receptor 0.0027 0.002 0.002
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.057 0.0915 0.264
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0027 0.002 0.0103
Trichomonas vaginalis PIKK family atypical protein kinase 0.0528 0.0847 0.5857
Brugia malayi hypothetical protein 0.0027 0.002 0.0139
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0215 0.0331 0.0949
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0043
Echinococcus granulosus expressed conserved protein 0.0085 0.0116 0.0116
Toxoplasma gondii FATC domain-containing protein 0.0319 0.0502 0.5626
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0215 0.0331 0.17
Schistosoma mansoni fkbp-rapamycin associated protein 0.0304 0.0477 0.2175
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.058 0.0932 0.6446
Loa Loa (eye worm) RGS-3 protein 0.002 0.0009 0.0043
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0215 0.0331 0.3711
Toxoplasma gondii target of rapamycin (TOR), putative 0.0556 0.0892 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0122 0.0177 0.0906
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0026 0.0123
Echinococcus granulosus neuropeptides capa receptor 0.0027 0.002 0.002
Leishmania major protein kinase ck2 regulatory subunit, putative 0.0038 0.0039 0.0097
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0024 0.0014 0.0098
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0031 0.0026 0.5
Schistosoma mansoni adenoreceptor 0.0027 0.002 0.0091
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0064 0.0081 0.0503
Echinococcus multilocularis beta adrenergic receptor kinase 0.0024 0.0014 0.0014
Trypanosoma cruzi hypothetical protein, conserved 0.2111 0.3458 1
Onchocerca volvulus 0.0027 0.002 0.0378
Echinococcus granulosus biogenic amine 5HT receptor 0.0027 0.002 0.002
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0 0.0001
Loa Loa (eye worm) hypothetical protein 0.0052 0.0061 0.0311
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0064 0.0081 0.0367
Loa Loa (eye worm) hypothetical protein 0.0027 0.002 0.0103
Trichomonas vaginalis PIKK family atypical protein kinase 0.0556 0.0892 0.6169
Schistosoma mansoni hypothetical protein 0.0038 0.0038 0.017
Echinococcus multilocularis rhodopsin orphan GPCR 0.0027 0.002 0.002
Echinococcus granulosus rhodopsin orphan GPCR 0.0027 0.002 0.002
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0122 0.0177 0.0502
Onchocerca volvulus 0.0122 0.0177 0.3334
Loa Loa (eye worm) G-protein coupled receptor 0.0027 0.002 0.0103
Schistosoma mansoni serine/threonine protein kinase 0.0024 0.0014 0.0064
Schistosoma mansoni hypothetical protein 0.0054 0.0064 0.029
Onchocerca volvulus 0.0027 0.002 0.0378
Plasmodium vivax hypothetical protein, conserved 0.0122 0.0177 0.5328
Leishmania major hypothetical protein, conserved 0.2233 0.3659 1
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0122 0.0177 0.0176
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0027 0.002 0.002
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0215 0.0331 0.349
Echinococcus multilocularis rhodopsin orphan GPCR 0.0027 0.002 0.002
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0215 0.0331 0.151
Onchocerca volvulus 0.0245 0.038 0.7194
Schistosoma mansoni amine GPCR 0.0027 0.002 0.0091
Loa Loa (eye worm) hypothetical protein 0.0031 0.0027 0.0135
Trichomonas vaginalis PIKK family atypical protein kinase 0.0556 0.0892 0.6169
Loa Loa (eye worm) hypothetical protein 0.0027 0.002 0.0103
Trichomonas vaginalis phosphofructokinase, putative 0.0113 0.0163 0.1076
Entamoeba histolytica hypothetical protein 0.0038 0.0038 0.0202
Trichomonas vaginalis phosphofructokinase, putative 0.0113 0.0163 0.1076
Trichomonas vaginalis CMGC family protein kinase 0.0143 0.0211 0.1416
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0043 0.0047 0.0269
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0215 0.0331 0.0331
Brugia malayi M-phase phosphoprotein, mpp8 0.0105 0.0149 0.1029
Trichomonas vaginalis CAMK family protein kinase 0.01 0.0141 0.0927
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0053 0.0063 0.0063
Schistosoma mansoni neuropeptide receptor 0.0027 0.002 0.0091
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0137 0.0202 0.0575
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0122 0.0177 0.1223
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0027 0.002 0.0103
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0242 0.0375 0.1076
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0122 0.0177 0.1979
Toxoplasma gondii ck2 beta subunit 0.0038 0.0039 0.0434
Toxoplasma gondii hypothetical protein 0.002 0.0009 0.0102
Loa Loa (eye worm) hypothetical protein 0.0105 0.0149 0.0763
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0028 0.0022 0.0093
Echinococcus granulosus axis inhibition protein axin 0.002 0.0009 0.0008
Loa Loa (eye worm) neuropeptide F receptor 0.0027 0.002 0.0103
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0068 0.0413
Brugia malayi hypothetical protein 0.0027 0.002 0.0139
Schistosoma mansoni hypothetical protein 0.0027 0.002 0.0091
Brugia malayi larval opioid receptor 0.0027 0.002 0.0139
Echinococcus granulosus rhodopsin orphan GPCR 0.0027 0.002 0.002
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0043 0.0047 0.0269
Brugia malayi hypothetical protein 0.0038 0.0038 0.0259
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0354 0.056 0.5976
Loa Loa (eye worm) hypothetical protein 0.017 0.0257 0.1317
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.002 0.0009 0.0008
Trypanosoma cruzi cytochrome P450, putative 0.002 0.0009 0.0017
Onchocerca volvulus 0.0027 0.002 0.0378
Giardia lamblia Hypothetical protein 0.0122 0.0177 0.166
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0364 0.0576 0.396
Schistosoma mansoni regulator of G protein signaling 0.002 0.0009 0.0038
Echinococcus granulosus neuropeptide Y receptor 0.0027 0.002 0.002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0541 0.0869 0.6005
Entamoeba histolytica serine/threonine protein kinase, putative 0.02 0.0306 0.2074
Onchocerca volvulus 0.0038 0.0038 0.0705
Trypanosoma brucei polo-like protein kinase 0.02 0.0306 0.3214
Echinococcus granulosus neuropeptide s receptor 0.0027 0.002 0.002
Trichomonas vaginalis CAMK family protein kinase 0.02 0.0306 0.2074
Trichomonas vaginalis PIKK family atypical protein kinase 0.0517 0.0829 0.5728
Loa Loa (eye worm) hypothetical protein 0.0027 0.002 0.0103
Brugia malayi FAT domain containing protein 0.0214 0.0328 0.2274
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0009 0.0008
Schistosoma mansoni hypothetical protein 0.0085 0.0116 0.0528
Schistosoma mansoni serine/threonine protein kinase 0.0335 0.0529 0.2412
Trichomonas vaginalis PIKK family atypical protein kinase 0.0319 0.0502 0.3444
Schistosoma mansoni biogenic amine receptor 0.0027 0.002 0.0091
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0215 0.0331 0.0331
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0045
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0122 0.0177 0.0804
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0888 0.1441 1
Schistosoma mansoni serine/threonine protein kinase 0.0024 0.0014 0.0064
Echinococcus multilocularis g protein coupled receptor 0.0027 0.002 0.002
Onchocerca volvulus 0.0027 0.002 0.0378
Schistosoma mansoni 6-phosphofructokinase 0.0113 0.0163 0.0741
Loa Loa (eye worm) hypothetical protein 0.0027 0.002 0.0103
Brugia malayi Cytochrome P450 family protein 0.0031 0.0027 0.0184
Schistosoma mansoni myosin xvIII 0.0027 0.002 0.0091
Entamoeba histolytica hypothetical protein 0.074 0.1196 0.8292
Giardia lamblia Kinase, CMGC CK2 0.0143 0.0211 0.2045
Echinococcus multilocularis neuropeptide Y receptor 0.0027 0.002 0.002
Brugia malayi hypothetical protein 0.0491 0.0786 0.5458
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0038 0.0039 0.021
Onchocerca volvulus 0.0027 0.002 0.0378
Schistosoma mansoni aryl hydrocarbon receptor 0.0051 0.0059 0.0269
Echinococcus multilocularis Ankyrin repeat domain containing protein 0.0093 0.0129 0.0129
Brugia malayi PXA domain containing protein 0.0021 0.0011 0.0075
Plasmodium falciparum glycogen synthase kinase 3 0.0053 0.0063 0.1723
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0009 0.0058
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0064 0.0081 0.0503
Trichomonas vaginalis PIKK family atypical protein kinase 0.0182 0.0276 0.1866
Echinococcus granulosus serotonin receptor 0.0027 0.002 0.002
Brugia malayi Protein kinase domain containing protein 0.0019 0.0006 0.0041
Echinococcus granulosus tm gpcr rhodopsin 0.0027 0.002 0.002
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0113 0.0163 0.9178
Brugia malayi 6-phosphofructokinase 0.0113 0.0163 0.1128
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0304 0.0477 0.0476
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0888 0.1441 1
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0215 0.0331 0.2251
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0027 0.012
Onchocerca volvulus 0.0027 0.002 0.0378
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0454 0.0725 0.5033
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0033 0.0031 0.003
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0215 0.0331 0.2251
Echinococcus granulosus rhodopsin orphan GPCR 0.0027 0.002 0.002
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0064 0.0081 0.0503
Brugia malayi neuropeptide F receptor 0.0027 0.002 0.0139
Onchocerca volvulus 0.0027 0.002 0.0378
Entamoeba histolytica casein kinase, putative 0.0143 0.0211 0.1416
Plasmodium falciparum GAF domain-related protein, putative 0.002 0.0009 0.0045
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0661 0.1066 0.738
Schistosoma mansoni hypothetical protein 0.0214 0.0328 0.1495
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0038 0.0039 0.0103
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.0081 0.0503
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0038 0.0037
Schistosoma mansoni amine GPCR 0.0027 0.002 0.0091
Trichomonas vaginalis PIKK family atypical protein kinase 0.056 0.09 0.6225
Schistosoma mansoni amine GPCR 0.0027 0.002 0.0091
Echinococcus granulosus neuropeptide FF receptor 2 0.0027 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0027 0.002 0.0103
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0517 0.0829 0.8886
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0122 0.0177 0.0176
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0009 0.0038
Loa Loa (eye worm) hypothetical protein 0.0027 0.002 0.0103
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0015 0 0.0000000064172
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0122 0.0177 0.5328
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0027 0.002 0.002
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0064 0.0081 0.0503
Brugia malayi G protein-coupled receptor 0.0027 0.002 0.0139
Brugia malayi Dopamine receptor 0.0027 0.002 0.0139
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0009 0.0008
Onchocerca volvulus 0.0028 0.0022 0.0403
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0027 0.002 0.0091
Loa Loa (eye worm) hypothetical protein 0.0027 0.002 0.0103
Trichomonas vaginalis PIKK family atypical protein kinase 0.0378 0.06 0.4129
Echinococcus multilocularis rhodopsin orphan GPCR 0.0027 0.002 0.002
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0027 0.002 0.002
Toxoplasma gondii hypothetical protein 0.0056 0.0068 0.076
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0038 0.0039 0.021
Loa Loa (eye worm) hypothetical protein 0.0027 0.002 0.0103
Echinococcus multilocularis neuropeptide Y receptor 0.0027 0.002 0.002
Plasmodium falciparum casein kinase 2, alpha subunit 0.0143 0.0211 0.63
Trypanosoma cruzi polo-like protein kinase, putative 0.02 0.0306 0.0875
Loa Loa (eye worm) hypothetical protein 0.0027 0.002 0.0103
Toxoplasma gondii phosphofructokinase PFKII 0.0031 0.0026 0.0294
Schistosoma mansoni hypothetical protein 0.0027 0.002 0.0091
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0027 0.002 0.0139
Loa Loa (eye worm) hypothetical protein 0.0105 0.0149 0.0762
Brugia malayi hypothetical protein 0.0027 0.002 0.0139
Schistosoma mansoni neuropeptide F-like receptor 0.0027 0.002 0.0091
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.057 0.0915 0.0915
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.058 0.0932 0.6466
Loa Loa (eye worm) hypothetical protein 0.0027 0.002 0.0103
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0033 0.0031 0.003
Echinococcus multilocularis tumor protein p63 0.0353 0.0557 0.0557
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0319 0.0502 0.1443
Loa Loa (eye worm) hypothetical protein 0.0197 0.0301 0.1546
Trichomonas vaginalis CMGC family protein kinase 0.0143 0.0211 0.1416
Echinococcus multilocularis transfer RNA-Lys 0.0038 0.0038 0.0037
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0122 0.0177 0.0176
Echinococcus multilocularis expressed protein 0.0389 0.0618 0.0618
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0064 0.0081 0.0503
Schistosoma mansoni amine GPCR 0.0027 0.002 0.0091
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0215 0.0331 1
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0009 0.0008
Schistosoma mansoni hypothetical protein 0.0122 0.0177 0.0804
Trichomonas vaginalis PIKK family atypical protein kinase 0.0342 0.054 0.3709
Echinococcus multilocularis g-protein coupled receptor 0.0027 0.002 0.002
Echinococcus granulosus tm gpcr rhodopsin 0.0027 0.002 0.002
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0026 0.0123
Echinococcus granulosus geminin 0.0175 0.0265 0.0265
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.057 0.0915 0.264
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0364 0.0576 0.6141
Schistosoma mansoni axis inhibition protein axin 0.002 0.0009 0.0038
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0027 0.002 0.0091
Schistosoma mansoni cellular tumor antigen P53 0.0052 0.0061 0.0276
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0027 0.002 0.002
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0028 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0027 0.002 0.0103
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.1342 0.219 0.219
Entamoeba histolytica protein kinase rad3, putative 0.0304 0.0477 0.3268
Trichomonas vaginalis PIKK family atypical protein kinase 0.0556 0.0892 0.6169
Plasmodium vivax glycogen synthase kinase 3, putative 0.0053 0.0063 0.1908
Echinococcus multilocularis G-protein coupled receptor, putative 0.0027 0.002 0.002
Echinococcus multilocularis somatostatin receptor 0.0027 0.002 0.002
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0215 0.0331 0.2296
Echinococcus granulosus serine:threonine protein kinase PLK1 0.02 0.0306 0.0305
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0027 0.002 0.0091
Loa Loa (eye worm) hypothetical protein 0.0027 0.002 0.0103
Schistosoma mansoni high voltage-activated calcium channel beta subunit 2 0.009 0.0125 0.0569
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0027 0.002 0.0091
Echinococcus granulosus intermediate filament protein 0.0028 0.0022 0.0021
Echinococcus granulosus nuclear factor of activated T cells 5 0.0077 0.0102 0.0102
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0443 0.0706 0.4871
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0063 0.0382
Echinococcus multilocularis rhodopsin orphan GPCR 0.0027 0.002 0.002
Schistosoma mansoni biogenic amine (5HT) receptor 0.0027 0.002 0.0091
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0024 0.0014 0.0073
Echinococcus granulosus 6 phosphofructokinase 0.0113 0.0163 0.0162
Schistosoma mansoni regulator of G protein signaling 0.002 0.0009 0.0038
Loa Loa (eye worm) hypothetical protein 0.0027 0.002 0.0103
Trichomonas vaginalis casein kinase II beta chain, putative 0.0038 0.0039 0.021
Echinococcus granulosus Regulator of G protein signaling 20 0.002 0.0009 0.0008
Echinococcus multilocularis allatostatin A receptor 0.0027 0.002 0.002
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0364 0.0576 0.3994
Echinococcus multilocularis neuropeptide receptor 0.0027 0.002 0.002
Entamoeba histolytica hypothetical protein 0.0122 0.0177 0.1172
Brugia malayi hypothetical protein 0.017 0.0257 0.1779
Echinococcus granulosus lamin dm0 0.0028 0.0022 0.0021
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0064 0.0081 0.0503
Trichomonas vaginalis PIKK family atypical protein kinase 0.0536 0.0861 0.5949
Loa Loa (eye worm) phosphatidylinositol 3 0.0122 0.0177 0.0906
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0027 0.002 0.002
Echinococcus multilocularis protein kinase shaggy 0.0053 0.0063 0.0063
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.058 0.0932 1
Onchocerca volvulus 0.0027 0.002 0.0378
Brugia malayi AKH receptor 0.0027 0.002 0.0139
Schistosoma mansoni kinase 0.0103 0.0146 0.0663
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0012 0.0024
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0009 0.0008
Loa Loa (eye worm) hypothetical protein 0.0027 0.002 0.0103
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0064 0.0081 0.0503
Echinococcus granulosus neuropeptides capa receptor 0.0027 0.002 0.002
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0315 0.0495 0.3397
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0027 0.002 0.0139
Loa Loa (eye worm) phosphatidylinositol 3-kinase catalytic subunit gamma 0.005 0.0058 0.0295
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0053 0.0063 0.0174
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.002 0.0009 0.0043
Schistosoma mansoni single-minded 0.0051 0.0059 0.0269
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0027 0.002 0.002
Trichomonas vaginalis DNA helicase recq1, putative 0.0022 0.0012 0.0024
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0038 0.0037
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0033 0.0031 0.0139

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 48 % QT interval was determined during cardiovascular test in normotensive male albino Long-Evans rat ChEMBL. 11300868
ED50 (functional) = 0.32 mg kg-1 In vivo antinociceptive activity was determined using in rat abdominal irritant test (RAIT) assay ChEMBL. 11300868
Inhibition (functional) = 100 % In vivo antinociceptive activity was determined by mouse abdominal irritant test (MAIT) in male pathogen free albino CD-1 mice ChEMBL. 11300868
Ki (binding) = 0.29 nM In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat ChEMBL. 11300868

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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